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Slaton Case, MD

What to Say

Patient explanations for medications, vaccines, tests, results, conditions, and hard questions.

827 entries

Medications

A–F

Acamprosate (Campral)Alcohol use disorder

What to say

Acamprosate helps you stay off alcohol now that you’ve stopped drinking, and it works best with counseling or a support group. Take two 333-milligram tablets, 666 milligrams in all, three times a day. Swallow them whole; taking them with meals helps you remember. It won’t treat withdrawal or make you sick if you drink. If you do drink, keep taking it and tell us. If you miss a dose, take it when you remember unless the next one is almost due.

Diarrhea is the most common side effect; nausea, gas or itching can also happen. Call us if diarrhea is severe or you can’t keep fluids down. Call the same day for worsening low mood or thoughts of self-harm, and ask family to tell us about changes they notice. If you might act on those thoughts, call 911. 988 can provide crisis support. If you could become pregnant, tell us, because pregnancy needs a different plan.

Clinical reference

Dose options

Adult AUD, CrCl >50 mL/min

666 mg (two 333-mg delayed-release tablets) orally three times daily

Start as soon as possible after withdrawal, once abstinent; continue through lapses. With or without food; dosing with meals, as in trials, helps adherence. Swallow whole.

Renal impairment

CrCl 30–50 mL/min: 333 mg three times daily; CrCl ≤30: contraindicated

APA 2018 also advises against first-line use in mild–moderate renal impairment and a reduced dose if used; the label reduces only at CrCl 30–50. No hepatic adjustment (Child-Pugh A–B).

  • Efficacy is established only when started after detoxification and abstinence; a trial in non-abstinent and polysubstance-using patients was negative.

Before prescribing

Confirm moderate–severe AUD, an abstinence goal and completed withdrawal. Check CrCl, depression/suicide risk, pregnancy and breastfeeding. Favored over naltrexone with opioid use or anticipated need, or acute hepatitis/liver failure.

Side effects and return precautions

Diarrhea (most common), nausea, flatulence, pruritus. Suicidal events exceeded placebo in trials (1.4% vs 0.5%); monitor mood. Rare acute kidney failure. No effect on withdrawal and no disulfiram-like reaction.

Follow-up

Review within 2–4 weeks, then regularly: drinking, adherence to three-times-daily dosing, mood and side effects. Recheck renal function in older adults or CKD. Continue through lapses with counseling or mutual-help support.

Sources

Checked October 15, 2026.

Acetaminophen (Tylenol)Pain and fever

What to say

For pain, you can take two 500-milligram acetaminophen tablets up to three times a day if needed. Keep doses at least six hours apart, and take no more than six of these tablets in any 24 hours. That’s a total limit of 3,000 milligrams from all products combined.

Check cold medicines, sleep products and prescription pain pills: many already contain acetaminophen, sometimes listed as APAP. Tell us about liver disease or regular heavy drinking before using it. If you take more than the limit, call Poison Control at 1-800-222-1222 immediately, even if you feel fine. Liver injury can be delayed. Stop it and call us immediately for assessment of any new rash. Go to the emergency department for blistering or mouth sores. Contact us if fever lasts more than three days, pain lasts more than ten days, or symptoms worsen sooner.

Clinical reference

Dose options

Adult, Extra Strength tablets

1,000 mg per dose, up to three doses/24 hours, at least 6 hours apart

Maximum 3,000 mg/day in this plan, including combination products.

Other strengths / risk factors

Use the actual product strength; liver disease, frailty or substantial alcohol use may require a lower limit or avoidance

This schedule does not apply to 650-mg extended-release tablets.

Before prescribing

Reconcile all acetaminophen-containing products and assess liver disease, alcohol use and regular warfarin treatment.

Side effects and return precautions

Usually well tolerated at appropriate doses; overdose can cause fatal liver injury before symptoms appear. Rare severe skin reactions.

Follow-up

Reassess persistent fever after 3 days or pain after 10 days, sooner for worsening or condition-specific red flags.

Sources

Checked September 20, 2026.

Acetazolamide (Diamox)Altitude-sickness prevention

What to say

Acetazolamide helps your body adjust to altitude. Take 125 milligrams every 12 hours, starting the day before you go up. Continue for the first two days at altitude, and longer if you keep ascending. We’ll write down your stop date based on the itinerary. You still need to ascend gradually.

Tingling in your fingers or toes, extra urination, and changes in taste can happen. Stop the medicine and seek care for a rash. Blistering, mouth sores, facial swelling or trouble breathing need emergency care.

If you develop a headache with nausea, dizziness or unusual fatigue, don’t go higher. Descend if symptoms worsen despite rest. Confusion, trouble walking straight or breathlessness at rest mean you need immediate help and descent with assistance. Don’t wait for the medicine to work.

Clinical reference

Dose options

Adult prevention

125 mg orally every 12 hours

Begin the day before ascent; continue for 2 days at altitude, longer during continued ascent.

Body weight >100 kg

250 mg orally every 12 hours

CDC prevention dose; change the dose in the wording above to match.

  • Prophylaxis is most useful for moderate/high-risk itineraries; assess prior altitude illness and planned sleeping elevations.
  • These doses follow CDC prevention guidance; the product label lists higher altitude-illness doses.

Before prescribing

Assess kidney/liver function, electrolytes, pregnancy, allergy history and interactions. Contraindicated with marked renal/hepatic dysfunction, cirrhosis, low sodium/potassium, adrenal insufficiency, hyperchloremic acidosis or acetazolamide hypersensitivity. Review high-dose aspirin, other carbonic anhydrase inhibitors, lithium and sodium bicarbonate. A sulfa-antibiotic allergy alone does not automatically exclude use; clarify severe reactions before prescribing.

Side effects and return precautions

Possible electrolyte loss, metabolic acidosis, kidney stones and rare serious skin or blood reactions. Stop and assess suspected hypersensitivity. Severe altitude illness requires urgent descent and emergency care.

Follow-up

Document start/stop dates and an evacuation plan before departure. The label recommends baseline CBC/platelets, repeat blood counts during therapy and periodic electrolytes; individualize monitoring to risk and duration.

Sources

Checked September 22, 2026.

Acyclovir (Zovirax)First genital herpes episode

What to say

For this first genital herpes episode, take acyclovir 400 milligrams three times a day for ten days. It helps the sores heal but doesn’t remove the virus from the body. Drink adequate fluids unless you have a fluid restriction.

Avoid sexual contact until the sores have healed and symptoms are gone. Herpes can also spread when no sores are visible. Condoms reduce but don’t eliminate that risk. Contact us if healing is incomplete at the end of treatment. Inability to urinate, severe headache with neck stiffness, confusion or eye symptoms needs urgent assessment.

Clinical reference

Dose options

First genital herpes episode, immunocompetent adult

400 mg orally three times daily for 7–10 days

CDC regimen; the wording above uses 10 days. Extend if healing remains incomplete after 10 days. Adjust for renal impairment.

  • Zovirax is a historical U.S. oral brand name; use the available generic oral product. These are oral regimens, not topical or IV dosing.

Before prescribing

Review renal function, hydration, acyclovir/valacyclovir allergy and nephrotoxic medicines. Kidney impairment requires an indication-specific dose/interval plan. Pregnancy, immunocompromise or disseminated/neurologic infection changes management. Swab active lesions for HSV typing when possible and offer HIV testing.

Side effects and return precautions

Nausea, diarrhea or headache; new confusion, marked drowsiness or reduced urine output needs urgent assessment for toxicity. Severe allergy or a blistering rash is an emergency.

Follow-up

Review healing by the end of treatment and discuss an advance outbreak prescription versus suppression. New genital herpes during pregnancy needs prompt obstetric coordination.

Sources

Checked September 23, 2026.

Acyclovir (Zovirax)Genital herpes suppression

What to say

Take acyclovir 400 milligrams twice a day every day to reduce genital herpes outbreaks. Take it even when you feel well. This controls the infection but doesn’t cure it, and transmission is still possible. Avoid sex during warning symptoms or sores and use condoms to lower risk.

We’ll review how well it’s working and whether you want to continue at least yearly. Drink adequate fluids unless restricted. Let’s know about breakthrough outbreaks, new kidney problems or pregnancy. New confusion or markedly reduced urination needs urgent assessment.

Clinical reference

Dose options

Suppressive therapy, immunocompetent adult

400 mg orally twice daily

For this regimen, label renal adjustment at CrCl ≤10 is 200 mg twice daily. Pregnancy and HIV-related regimens differ.

  • Zovirax is a historical U.S. oral brand name; use the available generic oral product. These are oral regimens, not topical or IV dosing.

Before prescribing

Review renal function, hydration, acyclovir/valacyclovir allergy and nephrotoxic medicines. Kidney impairment requires an indication-specific dose/interval plan. Pregnancy, immunocompromise or disseminated/neurologic infection changes management. Confirm symptomatic recurrent HSV and patient goals. Reserve genital HSV-1 suppression for frequent recurrences after discussion.

Side effects and return precautions

Nausea, diarrhea or headache; new confusion, marked drowsiness or reduced urine output needs urgent assessment for toxicity. Severe allergy or a blistering rash is an emergency.

Follow-up

Review yearly; routine treatment breaks or lab monitoring are not required in otherwise healthy patients. Monitor renal function when clinical risks warrant it. Do not promise prevention of partner transmission.

Sources

Checked September 23, 2026.

Acyclovir (Zovirax)Recurrent genital herpes episode

What to say

Keep this prescription available so you can start at the first tingling or burning, or within a day of sores appearing. Take acyclovir 800 milligrams twice a day for five days. This short course treats an outbreak. It isn’t the daily prevention schedule.

Avoid sex from the first warning symptoms until sores have healed and symptoms are gone. Drink adequate fluids unless restricted. Call if the episode is unusually severe, doesn’t improve or keeps recurring. We can discuss daily suppression. New confusion, very little urine, eye symptoms or difficulty urinating needs urgent assessment.

Clinical reference

Dose options

Recurrent genital HSV-2, immunocompetent adult

800 mg orally twice daily for 5 days

CDC alternative: 800 mg three times daily for 2 days. Select one complete regimen; renal impairment needs individualized adjustment.

  • Zovirax is a historical U.S. oral brand name; use the available generic oral product. These are oral regimens, not topical or IV dosing.

Before prescribing

Review renal function, hydration, acyclovir/valacyclovir allergy and nephrotoxic medicines. Kidney impairment requires an indication-specific dose/interval plan. Pregnancy, immunocompromise or disseminated/neurologic infection changes management. Confirm a recurrent episode rather than a first episode or another cause of genital ulcers.

Side effects and return precautions

Nausea, diarrhea or headache; new confusion, marked drowsiness or reduced urine output needs urgent assessment for toxicity. Severe allergy or a blistering rash is an emergency.

Follow-up

Provide advance access and clear start instructions. Reassess atypical or persistent lesions and discuss suppression if episodes are frequent or distressing.

Sources

Checked September 23, 2026.

Acyclovir (Zovirax)Shingles

What to say

Take acyclovir 800 milligrams five times a day for seven days for shingles. Space the doses about four hours apart while awake. You don’t need to wake overnight. Start as soon as possible. It helps the rash heal, but pain can persist and may need separate treatment. Drink adequate fluids unless you have a fluid restriction.

Keep the rash covered and avoid contact with susceptible pregnant people, newborns and people with weakened immune systems until every blister has crusted. A rash near the eye, eye pain, vision changes or new facial weakness needs same-day urgent assessment. Call promptly for confusion, much less urine or a spreading rash.

Clinical reference

Dose options

Adult localized shingles, usual renal function

800 mg orally about every 4 hours while awake, 5 times daily, for 7–10 days

The wording above uses 7 days. Start ideally within 72 hours; assess later presentation, new lesions and complications individually.

Label renal adjustment for the 800-mg shingles regimen

CrCl >25: usual schedule; 10–25: 800 mg every 8 hours; <10: 800 mg every 12 hours

Dialysis needs a specific dosing/timing plan. Do not apply this table to other HSV regimens.

  • Zovirax is a historical U.S. oral brand name; use the available generic oral product. These are oral regimens, not topical or IV dosing.

Before prescribing

Review renal function, hydration, acyclovir/valacyclovir allergy and nephrotoxic medicines. Kidney impairment requires an indication-specific dose/interval plan. Pregnancy, immunocompromise or disseminated/neurologic infection changes management.

Side effects and return precautions

Nausea, diarrhea or headache; new confusion, marked drowsiness or reduced urine output needs urgent assessment for toxicity. Severe allergy or a blistering rash is an emergency.

Follow-up

Reassess persistent new lesions, worsening illness or pain. Discuss shingles vaccination after the acute episode resolves.

Sources

Checked September 23, 2026.

Albuterol inhaler (Ventolin HFA)Exercise-induced bronchoconstriction prevention

What to say

To prevent the exercise-related wheezing we’ve diagnosed, use two puffs of Ventolin HFA 15 to 30 minutes before exercise. Let’s check your technique and spacer use. This is part of your written breathing plan. Keep any prescribed anti-inflammatory inhaler treatment going.

Shakiness or a racing heartbeat can happen. If you need it frequently, symptoms break through, or it’s working less well, contact us so we can reassess control. Follow your rescue plan for symptoms that develop. Severe breathlessness or rescue treatment that isn’t helping means call 911.

Clinical reference

Dose options

Ventolin HFA 90 mcg albuterol base per puff

2 inhalations 15–30 minutes before exercise

Count this use in the overall action plan; do not stack repeated unscheduled doses. Frequent need warrants reassessment of asthma control.

Before prescribing

Confirm exercise-induced bronchospasm, inhaler technique, spacer use and access. Review asthma control, cardiac risk and the full ICS-containing treatment plan when asthma is present.

Side effects and return precautions

Tremor, nervousness and tachycardia; immediate worsening after inhalation can be paradoxical bronchospasm. Severe respiratory distress or failed rescue needs emergency care.

Follow-up

Review prevention benefit and frequency of use in 2–4 weeks, earlier for poor response or increasing rescue need.

Sources

Checked September 23, 2026.

Albuterol inhaler (Ventolin HFA)Relief of bronchospasm

What to say

This is your quick-relief inhaler. Use two puffs when wheezing or tight breathing occurs, following the timing and limits in your written plan. The routine prescription is every four to six hours as needed. If you need it sooner or it isn’t helping, follow the next steps in your written breathing plan rather than repeatedly adding puffs.

Let me watch you use it. A spacer can help the medicine reach your lungs. Shakiness or a brief faster heartbeat can happen. Keep track of the dose counter so it doesn’t run out unexpectedly. This doesn’t replace the medicine that prevents airway inflammation. If you’re too breathless to speak normally or the rescue treatment isn’t working as the plan says it should, call 911.

Clinical reference

Dose options

Usual outpatient rescue

Albuterol HFA 90 mcg base/puff: 2 puffs every 4–6 hours as needed

Some patients use one puff every four hours; individualize and demonstrate technique.

Escalation limit

Do not convert the routine dose into an unsupervised acute-exacerbation protocol

More frequent need or inadequate relief requires action-plan reassessment. Nebulizer doses are different.

Before prescribing

Confirm diagnosis, controller strategy, device/strength, technique, spacer suitability and access. Check cardiac/medication context. Asthma needs an ICS-containing strategy; albuterol alone is not preventive treatment.

Side effects and return precautions

Tremor, nervousness and tachycardia; immediate worsening after inhalation can be paradoxical bronchospasm. Severe respiratory distress or failed rescue needs emergency care.

Follow-up

Give a written dose/interval/maximum and emergency plan. Review increasing use or nighttime symptoms, and demonstrate technique at follow-up.

Sources

Checked September 23, 2026.

Albuterol/budesonide (Airsupra)Asthma rescue

What to say

Airsupra is a quick-relief inhaler that also contains a low dose of inhaled steroid. Used for symptoms, it lowers the chance of a serious asthma attack compared with albuterol alone. When you have symptoms, take two puffs. You can repeat this if needed, but don’t use more than 12 puffs in 24 hours. It replaces your albuterol inhaler. If you take a daily controller, keep taking it. Shake Airsupra before each puff, and let’s practice priming it.

Shakiness, a fast heartbeat, headache, cough or hoarseness can happen. Rinse your mouth with water and spit after use to help prevent thrush. Call us the same day if you need it more than usual, it isn’t helping as well, or you’re close to 12 puffs in a day. If a puff makes breathing suddenly worse, stop it and get urgent help. Severe breathlessness or trouble speaking means call 911. If the pharmacy says it isn’t covered, tell us; we have other options.

Clinical reference

Dose options

As-needed reliever, adults 18 and older

90/80 mcg per actuation: 2 inhalations as needed; maximum 6 doses (12 inhalations) per 24 hours

GINA 2026: if more than 12 inhalations are needed in 24 hours, seek care the same day. Not for scheduled maintenance; continue maintenance ICS or ICS-LABA.

Place in therapy (GINA 2026 Track 2)

Step 1: as-needed-only ICS-SABA; Steps 2–5: reliever alongside maintenance ICS or ICS-LABA

Do not combine with ICS-formoterol MART, which uses ICS-formoterol as the reliever. GINA still prefers Track 1 ICS-formoterol. Labeled for asthma only, not COPD.

Device

Prime with 4 sprays before first use; 2 sprays if unused >7 days, dropped or after cleaning

Rinse the actuator with warm water weekly and air-dry. Discard 12 months after opening the pouch or when the counter reaches 0.

  • In adults, the label reports fewer severe exacerbations than with albuterol: 28% lower risk in MANDALA (patients on maintenance therapy) and 46% lower in BATURA (mostly SABA alone).

Before prescribing

Confirm asthma (not COPD) and age ≥18. It replaces albuterol and is not added to ICS-formoterol MART. Review cardiac disease, seizures, hyperthyroidism, diabetes, hypokalemia, beta-blockers, MAOIs/TCAs, diuretics, digoxin, strong CYP3A4 inhibitors and coverage.

Side effects and return precautions

Headache, oral candidiasis, cough, dysphonia; tremor or tachycardia, hypokalemia. Paradoxical bronchospasm (often with a new canister) and hypersensitivity need urgent care. Frequent use approaching 12 inhalations/day signals uncontrolled asthma.

Follow-up

Review reliever counts, symptoms, exacerbations and technique 1–3 months after starting. Step up maintenance if reliever use stays frequent. Review within 1 week after any exacerbation.

Sources

Checked October 15, 2026.

Alendronate (Fosamax)Osteoporosis treatment

What to say

Alendronate helps lower the chance of a fracture over time. Take 70 milligrams once a week on [day], first thing after getting up. Use a full glass, six to eight ounces, of plain water. Swallow it whole.

Wait at least 30 minutes before food, other drinks or other medicines. Stay sitting or standing for at least 30 minutes and until after your first food of the day. If you develop painful swallowing, chest pain when swallowing or new or worsening heartburn, stop it and contact us promptly. Tell me about new thigh or groin pain and tell your dentist you take it. We’ll review your calcium and vitamin D intake and how this routine is working.

Clinical reference

Dose options

Osteoporosis treatment

70 mg orally once weekly OR 10 mg daily

The wording above uses the weekly tablet.

Renal / administration

Not recommended at CrCl <35 mL/min

Correct hypocalcemia first; avoid with esophageal emptying disorders or inability to remain upright.

Before prescribing

Check calcium/vitamin D adequacy, renal function, esophageal disease, ability to follow the routine and dental issues. Review pregnancy and fracture-risk indication. Discontinue if pregnancy is recognized.

Side effects and return precautions

Esophageal irritation; rare osteonecrosis of jaw and atypical femur fracture. Stop and assess swallowing pain/new worsening heartburn. Acute concerning chest pressure still needs emergency assessment.

Follow-up

Early review of administration and tolerance; repeat bone density based on risk, often 1–2 years after initiation. Reassess fracture risk after 3–5 years to decide continuation/holiday. Missed weekly dose: take next morning, then return to usual day; never two on one day.

Sources

Checked September 23, 2026.

Alendronate (Fosamax)Postmenopausal osteoporosis prevention

What to say

After reviewing your bone density and fracture risk, I’m recommending alendronate to help prevent further bone loss after menopause. Take 35 milligrams once weekly on [day], first thing after getting up, with six to eight ounces of plain water. Swallow it whole. This is the prevention dose, not the weekly treatment dose for established osteoporosis.

Wait at least 30 minutes before food, other drinks or other medicines. Stay sitting or standing for at least 30 minutes and until after your first food of the day. If you develop painful swallowing, chest pain when swallowing or new or worsening heartburn, stop it and contact us promptly. Tell me about new thigh or groin pain and tell your dentist you take it. We’ll review your calcium and vitamin D intake and how this routine is working.

Clinical reference

Dose options

Postmenopausal osteoporosis prevention

35 mg once weekly, or 5 mg daily; the wording above uses the weekly regimen

Use only after an individual fracture-risk decision. Established osteoporosis uses a different regimen.

Renal / administration

Not recommended at CrCl <35 mL/min

Correct hypocalcemia first; avoid with esophageal emptying disorders or inability to remain upright.

Before prescribing

Check calcium/vitamin D adequacy, renal function, esophageal disease, ability to follow the routine and dental issues. Review pregnancy and fracture-risk indication. Discontinue if pregnancy is recognized.

Side effects and return precautions

Esophageal irritation; rare osteonecrosis of jaw and atypical femur fracture. Stop and assess swallowing pain/new worsening heartburn. Acute concerning chest pressure still needs emergency assessment.

Follow-up

Early review of administration and tolerance; repeat bone density based on risk, often 1–2 years after initiation. Reassess fracture risk after 3–5 years to decide continuation/holiday. Missed weekly dose: take next morning, then return to usual day; never two on one day.

Sources

Checked September 23, 2026.

Allopurinol (Zyloprim)Long-term gout prevention

What to say

Allopurinol lowers uric acid to prevent future gout attacks. Start 100 milligrams once a day after food. This is a daily prevention medicine. It doesn’t treat today’s attack. We’ll use [flare-prevention medicine and schedule] while we gradually adjust it.

Gout attacks can happen more often at first, even though the medicine is doing its job. If an attack happens, follow the flare plan and keep taking allopurinol unless we tell you otherwise. A new rash is different: stop allopurinol immediately and call the same day. Rash with blisters, mouth sores, fever or facial swelling means go to the emergency department. Breathing trouble means call 911. We’ll repeat uric acid and the safety blood tests, then increase gradually until we reach our target.

Clinical reference

Dose options

Gout start

Usually 100 mg orally daily; lower in CKD

ACR recommends ≤100 mg/day, lower in CKD; current label uses 50 mg daily at eGFR >30–60 with longer intervals at lower eGFR.

Titrate to target

Increase gradually using serial urate, tolerance and renal context; target serum urate <6 mg/dL

Label adult maximum 800 mg/day; doses >300 mg/day should be divided. Do not leave everyone at 100 mg if above target.

Flare prophylaxis

Use appropriate colchicine, NSAID or other anti-inflammatory prophylaxis when starting

ACR recommends at least 3–6 months, with extension if flares continue; choose from comorbidities and interactions.

Before prescribing

Check urate, CBC, chemistry, renal/liver function and interacting drugs, particularly azathioprine/mercaptopurine. Consider HLA-B*58:01 testing before initiation for patients of Southeast Asian descent and African American patients per ACR. Not routine treatment for asymptomatic hyperuricemia.

Side effects and return precautions

Rash/hypersensitivity can be life-threatening: stop immediately for any new rash. Check liver/renal symptoms and cytopenia risks. An ordinary gout flare is not a reason to stop established therapy.

Follow-up

Serial urate during titration, often every few weeks; adjust starting/titration interval for CKD. Repeat renal/liver/CBC monitoring according to label/risk; explain long-term adherence and prophylaxis duration.

Sources

Checked September 20, 2026.

Alprazolam (Xanax)Anxiety and panic disorder

What to say

Alprazolam acts fast but wears off fast, so anxiety can return between doses, and your body adapts quickly. If you’re starting, take 0.25 to 0.5 milligrams 3 times a day, short term, while an antidepressant or therapy takes effect. If you already take it daily, don’t stop on your own; withdrawal can cause seizures. We’ll lower it slowly together.

It can cause sleepiness, unsteadiness and memory gaps; don’t drive until you know its effect. Mixing it with alcohol, opioids or other sedatives can stop your breathing. Ask us before any new medicine, especially antifungals or antibiotics. Keep it locked away. Call us the same day if you run out or feel shaky between doses. Call 911 for a seizure or if someone is hard to wake or breathing slowly. For suicidal thoughts, call or text 988. Tell us if you’re pregnant or planning pregnancy.

Clinical reference

Dose options

Adult GAD (immediate-release)

0.25–0.5 mg orally three times daily; adjust every 3–4 days; maximum 4 mg/day

Labeled for acute treatment; use the lowest effective dose and reassess the need often. Older adults or hepatic impairment: start 0.25 mg two or three times daily.

Adult panic disorder (IR or XR)

IR 0.5 mg three times daily, raised by ≤1 mg/day every 3–4 days; XR 0.5–1 mg once each morning, usually 3–6 mg/day

Trials used 1–10 mg/day; above 4 mg/day, reassess and consider reduction. XR: swallow whole; switch from IR at the same total daily dose. Starting ritonavir: halve the dose for 10–14 days.

Dose reduction or stopping

Label: reduce by no more than 0.5 mg every 3 days; some patients need slower

After regular use, the 2025 joint guideline tapers far more slowly (see the long-term benzodiazepine card) and allows switching to a longer-acting benzodiazepine. Even 2–4 weeks of daily alprazolam may need a taper.

  • NICE: a benzodiazepine for GAD only short term during a crisis and none for panic disorder; long-term options are an SSRI (or SNRI) and CBT.

Before prescribing

Check CURES, indication, current dose and pattern, alcohol/opioid/sedative use, substance use disorder, depression/suicidality, sleep apnea or lung disease, falls and pregnancy. Contraindicated with strong CYP3A inhibitors except ritonavir (e.g., ketoconazole, itraconazole, clarithromycin).

Side effects and return precautions

Drowsiness, impaired coordination, memory problems, falls (Beers: avoid in older adults); interdose or early-morning rebound anxiety; misuse; mania; respiratory depression with opioids or lung disease; withdrawal seizures after abrupt stops. Digoxin levels may rise.

Follow-up

Review within 1–2 weeks of a start or change, then at each refill: use pattern, function, sedation and misuse. Optimize an SSRI/SNRI and CBT; for long-term users, agree on a gradual taper rather than stopping.

Sources

Checked October 21, 2026.

Amitriptyline (Elavil)Irritable bowel syndrome, off-label

What to say

Low-dose amitriptyline can calm the gut-brain signals behind IBS pain and bowel symptoms; at this dose it isn’t treating depression. This is an off-label use supported by gastroenterology guidelines. Take 10 milligrams in the evening. If symptoms aren’t controlled and side effects are mild, add 10 milligrams each week, up to 30 milligrams. It can take a few weeks to help. If it does, we’ll plan to continue it for about 6 months, then review.

Drowsiness, dry mouth and constipation are the most common side effects; tell us about constipation, because we can lower the dose or add a laxative. Don’t drive until you know how it affects you, and limit alcohol. Call us for trouble urinating, a racing or irregular heartbeat, fainting or worsening mood. For thoughts of self-harm, call 988; if you might act on them, call 911. We’ll prescribe a month at a time at first, because an overdose is dangerous.

Clinical reference

Dose options

IBS (off-label), ATLANTIS regimen

10 mg at night; increase in 10-mg steps over about 3 weeks as needed, to a maximum of 30 mg at night

Self-titrated to symptoms and side effects and continued for 6 months in the trial (second-line, primary care). ACG: start low (10 mg) and titrate gradually.

IBS subtype

Can be used in IBS-D, IBS-M and IBS-C

ACG: IBS-D may respond best. ATLANTIS post hoc analysis: benefit and similar tolerability across subtypes; monitor constipation.

  • ACG 2021 recommends TCAs for global IBS symptoms (strong recommendation, moderate-quality evidence). ATLANTIS (Lancet 2023): titrated 10–30 mg amitriptyline beat placebo as second-line therapy in primary care.

Before prescribing

Off-label. Confirm IBS, address alarm features and try first-line measures. Exclude recent MI, arrhythmia, heart block, long QT or QT drugs, HF, mania, severe liver disease, MAOI within 14 days. Caution: glaucoma, urinary retention, older age, serotonergic drugs.

Side effects and return precautions

Drowsiness, dry mouth, constipation and palpitations; urinary retention, orthostasis and falls, arrhythmia, hyponatremia, serotonin syndrome, mood change or suicidality. Overdose risk: limit the early supply.

Follow-up

Check tolerability after titration (about 3–4 weeks) and global symptoms by 3 months. If helpful, continue about 6 months, then review; taper when stopping.

Sources

Checked October 15, 2026.

Amitriptyline (Elavil)Migraine prevention, off-label

What to say

Low-dose amitriptyline, an older antidepressant, can help prevent migraines. This is an off-label use. Take 10 milligrams in the evening, about 2 hours before bed if mornings feel groggy. If you’re tolerating it, raise the dose by 10 milligrams every 1–2 weeks as we plan, often to 25–50 milligrams. It can also help sleep and tension-type headaches. Keep a headache diary; it takes 2–3 months at a steady dose to judge.

Dry mouth, constipation, drowsiness, dizziness and weight gain are common. Don’t drive until you know how it affects you, and limit alcohol. Call us for trouble urinating, a racing or irregular heartbeat, fainting, eye pain with blurred vision, or worsening mood. For thoughts of self-harm, call 988; if you might act on them, call 911. An overdose can be fatal, so we’ll prescribe limited amounts. Don’t add other antidepressants, tramadol or St. John’s wort without checking, and don’t stop suddenly.

Clinical reference

Dose options

Migraine prevention (off-label)

10 mg in the evening; increase by 10 mg every 1–2 weeks as tolerated, commonly to 25–50 mg; higher only if needed and tolerated

Trials used 25–100 mg; AAFP lists 25–150 mg once daily. Use the lowest effective dose and judge after 8–12 weeks at a tolerated dose.

Older adults

Prefer another preventive; if used, start at 10 mg and titrate slowly

AGS Beers 2023: avoid (strongly anticholinergic, sedating, orthostatic hypotension). AAN/AHS 2026: avoid anticholinergics in older men at risk of urinary retention.

  • 2026 AAN/AHS guideline: low-confidence evidence for episodic migraine; offer when higher-confidence options fail, or with comorbid fibromyalgia. Not FDA-approved for migraine.

Before prescribing

Off-label; use after higher-confidence preventives fail or with fibromyalgia or insomnia. Screen suicide risk (boxed warning through age 24), bipolar history, recent MI, conduction disease, QT drugs, angle-closure glaucoma, urinary retention, seizures, pregnancy. No MAOI within 14 days.

Side effects and return precautions

Anticholinergic effects, sedation, orthostasis and falls, weight gain, arrhythmia, hyponatremia, angle closure, serotonin syndrome (triptans, SSRIs/SNRIs, tramadol), mania or suicidality. CYP2D6 inhibitors and topiramate can raise levels. Overdose is cardiotoxic.

Follow-up

Check tolerability within a few weeks; assess efficacy at 8–12 weeks at a tolerated dose (AAN/AHS 2026). After about 6 months of good control, discuss tapering over several weeks.

Sources

Checked October 15, 2026.

Amitriptyline (Elavil)Nerve pain, off-label

What to say

Low-dose amitriptyline, an older antidepressant, can ease burning, shooting or tingling nerve pain. This is an off-label use supported by treatment guidelines. Take 10 milligrams in the evening. If you’re tolerating it, we’ll raise the dose every 1–2 weeks, usually to 25–75 milligrams. Sleep may improve first; pain relief builds over 4–6 weeks. It eases pain but doesn’t repair nerves, so keep up foot checks and diabetes care if you have diabetes.

Dry mouth, constipation, drowsiness, dizziness and weight gain are common. Stand up slowly, and don’t drive until you know how it affects you. Limit alcohol. Call us for trouble urinating, a racing or irregular heartbeat, fainting, eye pain with blurred vision, or worsening mood. For thoughts of self-harm, call 988; if you might act on them, call 911. An overdose can be fatal, so we’ll prescribe limited amounts. Check with us before adding other antidepressants or tramadol, and don’t stop suddenly.

Clinical reference

Dose options

Neuropathic pain (off-label)

10–25 mg at bedtime; increase every 1–2 weeks as tolerated; usually 25–75 mg, up to 100 mg

ADA range 25–100 mg/day; NHS caps pain dosing at 75 mg/day. Start at 10 mg in older or frail adults.

Older adults or cardiac disease

Prefer nortriptyline or another drug class

ADA: secondary amines are better tolerated; use TCAs cautiously with known or suspected heart disease. AGS Beers: avoid amitriptyline in older adults.

  • AAN 2022 painful diabetic neuropathy guideline: TCAs, SNRIs, gabapentinoids and sodium-channel blockers are all options; opioids should not be used. Amitriptyline is not FDA-approved for pain.

Before prescribing

Off-label. Confirm neuropathic pain; screen mood and sleep (AAN). Review recent MI, arrhythmia or conduction disease, QT drugs (consider ECG), glaucoma, urinary retention, falls, suicide risk, seizures, pregnancy. No MAOI within 14 days; review CYP2D6 inhibitors.

Side effects and return precautions

Dry mouth, constipation, sedation, dizziness and weight gain; orthostasis and falls, urinary retention, arrhythmia, hyponatremia, angle closure, serotonin syndrome and suicidality. Overdose can be fatal; limit supply when risk is present.

Follow-up

Reassess pain, function, sleep and side effects after 4–6 weeks at a tolerated dose. Without meaningful benefit, switch class (SNRI, gabapentinoid or sodium-channel blocker) per AAN 2022. Taper over weeks when stopping.

Sources

Checked October 15, 2026.

Amlodipine (Norvasc)Hypertension

What to say

I’m starting amlodipine 5 milligrams once a day to lower your blood pressure. Take it with or without food at a time that’s easy to remember. It works gradually, so we’ll judge it from your blood-pressure readings over the next few weeks.

The side effect I particularly want you to notice is ankle swelling. It can also cause flushing, headache or dizziness. Let me know if swelling or lightheadedness is bothersome. We can adjust the dose or choose another medicine. Don’t add a water pill on your own. Bring your home readings to our follow-up in about a month. If you have new chest pressure or severe breathlessness, call 911.

Clinical reference

Dose options

Usual start

5 mg orally once daily

Hypertension.

Lower start

2.5 mg once daily

Small/frail/older patients or hepatic insufficiency.

Titration / maximum

Adjust after about 7–14 days; maximum 10 mg daily

Titrate slowly with severe hepatic impairment; no initial renal adjustment needed.

Before prescribing

Check BP/orthostasis, edema history, hepatic disease and interactions, including simvastatin. New edema still needs assessment for other causes.

Side effects and return precautions

Common: dose-related ankle edema, flushing, headache, dizziness. New painful unilateral swelling needs same-day evaluation; chest pain, severe dyspnea or syncope may need emergency care.

Follow-up

Practical BP/edema review in 2–4 weeks. No routine lab panel solely for amlodipine. If missed, take unless fewer than 12 hours remain before the next dose; never double.

Sources

Checked September 20, 2026.

Amlodipine (Norvasc)Stable or vasospastic angina

What to say

We’re using amlodipine to prevent episodes of the angina we’ve diagnosed. Take 5 milligrams once daily, with or without food. We’ll review chest-pain frequency, activity and blood pressure before adjusting it. It’s a daily preventive medicine, not a rescue treatment for chest pain happening now.

Ankle swelling, flushing or dizziness can occur. Tell us if these are troublesome. New, severe or persistent chest pain, especially at rest or with sweating or breathlessness, means call 911. Keep following your separate chest-pain rescue plan.

Clinical reference

Dose options

Adult chronic stable or vasospastic angina

5–10 mg orally once daily; the wording above starts at 5 mg

Use the lower end initially in older adults or hepatic impairment; titrate slowly in severe liver disease. No routine renal adjustment.

Before prescribing

Confirm angina diagnosis and exclude an acute coronary syndrome. Review BP, hepatic impairment, severe aortic stenosis, edema and interactions. Ensure a separate rescue/emergency plan.

Side effects and return precautions

Common: dose-related ankle edema, flushing, headache, dizziness. New painful unilateral swelling needs same-day evaluation; chest pain, severe dyspnea or syncope may need emergency care.

Follow-up

Review symptoms, exercise tolerance, BP and swelling in 1–2 weeks. Worsening angina needs prompt reassessment rather than automatic dose escalation.

Sources

Checked September 23, 2026.

Amoxicillin (Amoxil)Pneumonia

What to say

Your exam and tests show pneumonia, an infection in the lungs. Take amoxicillin 1 gram, which is two 500-milligram capsules, three times a day, about every 8 hours, with or without food. Take it for at least 5 days; we’ll tell you when it’s safe to stop. Rest, drink fluids, and use acetaminophen for fever if it’s safe for you.

Most people feel better within 2 to 3 days, though cough and tiredness can last weeks. Call us if your fever isn’t improving by then. Get same-day care if you can’t keep fluids or pills down. Go to the emergency department for worsening breathing, chest pain or confusion; call 911 for severe trouble breathing or blue lips. Stop it and call the same day for hives or a new rash; face or tongue swelling means call 911. Call promptly for severe watery or bloody diarrhea.

Clinical reference

Dose options

Outpatient CAP without comorbidities or MRSA/Pseudomonas risk factors

1 g orally three times daily

ATS/IDSA 2019 (strong recommendation). Label dosing for lower respiratory tract infection is 875 mg every 12 hours or 500 mg every 8 hours; follow the guideline dose.

Duration

At least 5 days and until clinically stable (normal vital signs, eating, normal mentation)

ATS/IDSA 2019. The 2025 ATS update (not endorsed by IDSA) conditionally supports shorter courses, as few as 3 days, for nonsevere CAP once stable.

Renal adjustment

GFR 10–30 mL/min: 250–500 mg every 12 hours; <10: every 24 hours

Per label; avoid 875-mg tablets if GFR <30. Dialysis needs specific instructions.

Before prescribing

Confirm CAP and outpatient severity. Use only without chronic heart, lung, liver or renal disease, diabetes, alcohol use disorder, malignancy or asplenia, and without MRSA/Pseudomonas risk. Check β-lactam allergy, renal function and possible mononucleosis.

Side effects and return precautions

Rash, hypersensitivity/anaphylaxis, diarrhea and C. difficile. Not stable by day 5 or worsening: reassess for resistant pathogen, empyema, abscess or alternative diagnosis.

Follow-up

Recheck at 48–72 hours by phone or visit. Stop after ≥5 days once stable. If symptoms resolve within 5–7 days, routine follow-up chest imaging isn’t needed (ATS/IDSA 2019).

Sources

Checked October 15, 2026.

Amoxicillin (Amoxil)Strep throat

What to say

Your test confirms strep throat. Take amoxicillin 500 milligrams twice a day for ten days. Take it with or without food, and finish the prescribed course unless we change it because of a reaction or new information.

You should start feeling better over the next couple of days. Call if you aren’t improving after two to three days, or sooner for worsening symptoms. For drooling or inability to swallow fluids, go to the emergency department. For trouble breathing, call 911. Nausea, diarrhea or a rash can happen. Stop and call the same day for a new rash. Swelling of your tongue or trouble breathing means stop and call 911. Severe watery or bloody diarrhea needs a same-day call.

Clinical reference

Dose options

Confirmed group A streptococcal pharyngitis

500 mg orally twice daily OR 1,000 mg once daily for 10 days

Adult dose at the CDC weight-based maximum; confirm infection rather than treating viral sore throat.

Renal adjustment

Do not use 875-mg dose if GFR <30 mL/min

GFR 10–30: 250–500 mg every 12 hours; <10: every 24 hours, chosen by severity. Dialysis needs specific instructions.

Before prescribing

Confirm group A streptococcal pharyngitis, beta-lactam allergy and renal function; consider EBV when appropriate because aminopenicillin rash is common. Review warfarin/allopurinol and prior antibiotic complications.

Side effects and return precautions

GI upset, rash, anaphylaxis and severe antibiotic-associated diarrhea. Blistering/peeling or mucosal rash warrants stopping and emergency evaluation.

Follow-up

Reassess persistent/worsening throat symptoms after 48–72 hours. No routine test-of-cure after resolved uncomplicated strep unless a specific reason exists.

Sources

Checked September 20, 2026.

Amoxicillin/clavulanate (Augmentin)Bacterial sinusitis

What to say

Your symptom pattern fits a bacterial sinus infection, and we have decided to use an antibiotic. Take one amoxicillin/clavulanate 875/125-milligram tablet twice a day at the start of a meal for five days. The two numbers describe the two medicines in each tablet.

Loose stools or nausea can happen. Call if you’re getting worse or haven’t started improving after three to five days. Stop and call the same day for a new rash or severe watery or bloody diarrhea. Trouble breathing or swelling of the lips or tongue means stop it and call 911. Eye swelling, vision changes or a severe new headache means go to the emergency department.

Clinical reference

Dose options

Uncomplicated adult bacterial sinusitis

875/125 mg orally every 12 hours OR 500/125 mg every 8 hours, usually 5–7 days

Use when bacterial criteria and shared antibiotic decision are met; not for a routine viral cold.

Renal adjustment

Do not use the 875-mg tablet at GFR <30 mL/min

GFR 10–30: 500/125 or 250/125 mg every 12 hours; <10: every 24 hours, selected by severity. Dialysis requires a specific regimen.

Formulation check

Immediate-release regimen only

Different ratios and extended-release products are not interchangeable tablet-for-tablet.

Before prescribing

Confirm bacterial pattern, allergy type, prior amoxicillin/clavulanate-associated liver injury, renal function and interactions. Watchful waiting with assured follow-up is an option in selected uncomplicated disease.

Side effects and return precautions

GI upset and rash. Anaphylaxis: stop/911. Severe diarrhea requires same-day assessment, including possible C. difficile. Jaundice: stop and contact same day.

Follow-up

Reassess if worsening or failing to improve after 3–5 days of appropriate antibiotic therapy; investigate complications, diagnosis, resistance and adherence.

Sources

Checked September 20, 2026.

Amoxicillin/clavulanate (Augmentin)Diverticulitis, off-label

What to say

Your symptoms fit diverticulitis, inflammation of a small pouch in the colon wall. Many mild cases heal without antibiotics, but in your situation we’re adding one. Amoxicillin/clavulanate is commonly used for this, though it’s an off-label use. Take one 875/125-milligram tablet twice a day at the start of a meal for [4–7] days. Drink clear liquids while the pain is worst, then return to regular food as you feel better. For pain, use acetaminophen rather than ibuprofen or naproxen.

Loose stools or nausea can happen. Call the same day for a new rash, yellow skin or eyes, severe watery or bloody diarrhea, or if you still can’t eat normally after 3–5 days. Go to the emergency department for worsening belly pain, a rising fever, repeated vomiting, or if you can’t keep liquids down. Trouble breathing or swelling of the lips or tongue means stop it and call 911. Once you recover, we’ll check whether you need a colonoscopy.

Clinical reference

Dose options

Uncomplicated diverticulitis needing antibiotics

875/125 mg orally every 12 hours at the start of a meal, usually for 4–7 days

AGA 2021: amoxicillin/clavulanate monotherapy is a common outpatient choice, usually for 4–7 days, and longer (10–14 days) if immunocompromised. The dose is the label’s severe-infection regimen; intra-abdominal infection isn’t a labeled use.

Who should get antibiotics (ACP 2022, AGA 2021)

Immunosuppression, comorbidity or frailty, vomiting, symptoms >5 days, CRP >140 mg/L, WBC >15 × 10⁹/L, fluid collection or long inflamed segment on CT, or systemic signs

Immunocompetent adults with mild uncomplicated disease can be managed without antibiotics. Complicated disease needs urgent evaluation.

Renal adjustment

GFR <30: avoid the 875-mg tablet; GFR 10–30: 500/125 mg every 12 hours; GFR <10: every 24 hours

Hemodialysis: every 24 hours, plus a dose during and at the end of dialysis.

  • Off-label: US amoxicillin/clavulanate labeling doesn’t include intra-abdominal infection.

Before prescribing

Confirm the diagnosis (CT if uncertain), exclude complicated disease or sepsis, and confirm the patient can take fluids at home. Review penicillin allergy, prior amoxicillin/clavulanate liver injury, renal function, warfarin and allopurinol.

Side effects and return precautions

Diarrhea, rash, C. difficile and cholestatic hepatitis. Worsening pain, peritoneal signs, fever, intolerance of fluids or no improvement suggests abscess or perforation and needs same-day imaging or ED care.

Follow-up

Reassess if not improving or unable to advance the diet within 3–5 days. Colonoscopy 6–8 weeks after recovery: ACP after complicated disease; AGA also after a first uncomplicated episode without a high-quality colonoscopy within a year.

Sources

Checked October 15, 2026.

Amoxicillin/clavulanate (Augmentin)High-risk bite-wound infection prevention, off-label

What to say

Because this bite has a higher infection risk, we’re using a short preventive antibiotic course. This is an off-label use supported by bite-wound guidance. Take amoxicillin/clavulanate 875/125 milligrams twice daily at the start of a meal for 3 days. Keep following the cleaning and wound-care plan. We’ll also check tetanus and whether rabies prevention or other exposure care is needed.

Loose stools or nausea can occur. Contact us promptly for increasing redness, swelling, drainage, fever or difficulty moving the area. Rapidly spreading redness, severe pain or feeling very ill needs urgent care. Stop and call for a new rash or severe diarrhea. Breathing trouble or tongue swelling means call 911.

Clinical reference

Dose options

High-risk bite-wound infection prevention

875/125 mg orally twice daily for 3 days

Guideline-supported off-label indication. IDSA recommends 3–5 days of prophylaxis for selected high-risk bites; the wording above uses three.

Renal and product limits

Do not use the 875-mg tablet when GFR <30 mL/min

Choose a renal-adjusted formulation/schedule. Do not substitute extended-release tablets or different clavulanate ratios automatically.

Before prescribing

Assess wound depth, hand/joint/tendon involvement, foreign body, immune status, infection severity and need for irrigation or surgical assessment. Review penicillin allergy, renal function, prior amoxicillin/clavulanate liver injury, tetanus, rabies and human-bite blood-borne exposure risks.

Side effects and return precautions

GI upset, allergy, severe antibiotic-associated diarrhea and rare liver injury. Increasing pain, spreading erythema, fever or impaired function requires prompt reassessment.

Follow-up

Arrange wound review within 24–48 hours when indicated by site or risk. Reassess if infection develops or fails to begin improving within 24–48 hours. Antibiotics do not replace wound care or needed surgical treatment.

Sources

Checked September 23, 2026.

Amoxicillin/clavulanate (Augmentin)Infected human or animal bite

What to say

This bite wound appears infected, and we’re treating it with an antibiotic. Take amoxicillin/clavulanate 875/125 milligrams twice daily at the start of a meal for 5 days. Keep following the cleaning and wound-care plan. We’ll also check tetanus and whether rabies prevention or other exposure care is needed.

Loose stools or nausea can occur. Contact us promptly for increasing redness, swelling, drainage, fever or difficulty moving the area. Rapidly spreading redness, severe pain or feeling very ill needs urgent care. Stop and call for a new rash or severe diarrhea. Breathing trouble or tongue swelling means call 911.

Clinical reference

Dose options

Infected human or animal bite

875/125 mg orally twice daily for 5 days

Five days is suitable for many uncomplicated infected bites; deep-structure involvement or poor response requires reassessment and sometimes a different course or setting.

Renal and product limits

Do not use the 875-mg tablet when GFR <30 mL/min

Choose a renal-adjusted formulation/schedule. Do not substitute extended-release tablets or different clavulanate ratios automatically.

Before prescribing

Assess wound depth, hand/joint/tendon involvement, foreign body, immune status, infection severity and need for irrigation or surgical assessment. Review penicillin allergy, renal function, prior amoxicillin/clavulanate liver injury, tetanus, rabies and human-bite blood-borne exposure risks.

Side effects and return precautions

GI upset, allergy, severe antibiotic-associated diarrhea and rare liver injury. Increasing pain, spreading erythema, fever or impaired function requires prompt reassessment.

Follow-up

Arrange wound review within 24–48 hours when indicated by site or risk. Reassess if infection develops or fails to begin improving within 24–48 hours. Antibiotics do not replace wound care or needed surgical treatment.

Sources

Checked September 23, 2026.

Amphetamine/dextroamphetamine XR (Adderall XR)ADHD

What to say

I’m starting Adderall XR 20 milligrams once each morning for ADHD. This is the extended-release capsule. Take it with or without food. Swallow it whole, or open the capsule and sprinkle all its contents onto applesauce and swallow it immediately without chewing. Don’t divide the contents or save part for later.

It may reduce appetite, make sleep harder, or raise your pulse. We’ll track whether it improves the daily tasks that matter to you. Don’t take an extra dose when it wears off. If you forget until afternoon, skip it. Chest pain, fainting, or severe shortness of breath means call 911. Hallucinations or a major change in mood needs a same-day call. Keep it locked away and never share it. We’ll review benefit, sleep, blood pressure, pulse, and weight within two weeks and decide together whether the dose needs adjusting.

Clinical reference

Dose options

Labeled adult ADHD dose

20 mg orally once each morning

Individualize to the lowest effective dose; cautious lower starting doses may be selected. Titrate at weekly intervals; avoid afternoon dosing.

Dose ceiling distinction

No general adult maximum is stated in this label’s dosing section

Adult trials studied 20, 40 and 60 mg/day without adequate evidence of extra benefit above 20 mg/day. Do not present 60 mg as a routine labeled adult ceiling.

Renal / age limitations

GFR 15–<30: 15 mg each morning; GFR <15: not recommended

Not studied in geriatric patients. Review CYP2D6 inhibitors, serotonergic drugs and agents altering urinary pH; lower doses may be needed with interacting drugs.

Before prescribing

Assess cardiac/family history, BP/pulse/weight, ADHD impairment, bipolar/psychosis, tics and misuse risk. Avoid serious cardiac disease; MAOI use within 14 days is contraindicated. Review pregnancy, breastfeeding and other stimulants.

Side effects and return precautions

Boxed warning: abuse, misuse and addiction. Watch weight loss, insomnia, hypertension, mania/psychosis and digital circulation problems. Fever, confusion and rigidity with serotonergic combinations needs emergency assessment. Secure storage and refill planning matter.

Follow-up

Review early in titration; measure BP/pulse after dose changes and at least every 6 months, weight every 6 months or earlier if losing weight. Document functional benefit, sleep, adverse effects and continued need.

Sources

Checked September 20, 2026.

Apixaban (Eliquis)Atrial fibrillation

What to say

For your atrial fibrillation, we’re starting apixaban 5 milligrams twice daily to reduce the chance of a stroke. Take a morning and evening dose, with or without food. If you forget one, take it as soon as you remember that day and then resume the usual schedule. Don’t double doses. Don’t stop it for dental work or a procedure without a written plan from the treating team.

Bruising or minor bleeding can happen. Call the same day about repeated nosebleeds or bleeding that concerns you. Go to the emergency department for vomiting blood, black stools or a head injury. Call 911 for uncontrolled bleeding, fainting, a drooping face, arm weakness or trouble speaking. Check before using aspirin, ibuprofen or new prescriptions. We’ll review you in about a month and monitor blood counts and kidney function. This medicine doesn’t need routine INR testing.

Clinical reference

Dose options

Nonvalvular atrial fibrillation

5 mg orally twice daily

Reduce to 2.5 mg twice daily only when at least two apply: age ≥80, weight ≤60 kg, serum creatinine ≥1.5 mg/dL. Review dialysis/severe kidney disease separately.

Interactions and organ impairment

Strong combined CYP3A4/P-gp inhibitors require a 50% reduction of 5 or 10 mg doses; avoid if already taking 2.5 mg twice daily

Avoid strong inducers. Severe liver disease is not recommended. Trials did not establish outcomes for CrCl <15/dialysis; individualize rather than infer safety from renal labeling alone.

Before prescribing

Confirm indication and treatment phase, weight, CBC, kidney/liver function, bleeding history, pregnancy and all interacting drugs. Review antiplatelets/NSAIDs and Paxlovid. Mechanical valves, significant rheumatic mitral stenosis and high-risk antiphospholipid syndrome require a different anticoagulation strategy.

Side effects and return precautions

Bleeding and premature interruption are the major preventable harms. Provide clear head-injury and GI-bleeding instructions. Coordinate surgery, neuraxial procedures and any temporary interruption; bridging or stopping is not an automatic patient decision.

Follow-up

Review after one month for adherence and bleeding, then check CBC and kidney/liver function at least annually, more frequently with older age, CKD, frailty or intercurrent illness. No routine INR dose titration.

Sources

Checked September 22, 2026.

Apixaban (Eliquis)DVT or pulmonary embolism treatment

What to say

For the blood clot we’ve diagnosed, take apixaban 10 milligrams twice daily for seven days, then 5 milligrams twice daily starting on [date]. We’ll write both phases down so the change is clear. This helps keep the clot from growing and reduces new clots while your body clears it. Take it with or without food. If you miss a dose, take it when remembered that day. Don’t double up. Don’t interrupt it for a procedure without our plan.

Bruising or minor bleeding can happen. Call the same day about repeated nosebleeds or bleeding that concerns you. Go to the emergency department for vomiting blood, black stools or a head injury. Call 911 for uncontrolled bleeding, fainting, a drooping face, arm weakness or trouble speaking. Check before using aspirin, ibuprofen or new prescriptions. We’ll review you in about a month and monitor blood counts and kidney function. This medicine doesn’t need routine INR testing.

Clinical reference

Dose options

Acute DVT or pulmonary embolism

10 mg twice daily for seven days, then 5 mg twice daily

Do not apply AF age/weight/creatinine reduction criteria to acute VTE treatment. Confirm outpatient stability and the treatment phase.

Interactions and organ impairment

Strong combined CYP3A4/P-gp inhibitors require a 50% reduction of 5 or 10 mg doses; avoid if already taking 2.5 mg twice daily

Avoid strong inducers. Severe liver disease is not recommended. Trials did not establish outcomes for CrCl <15/dialysis; individualize rather than infer safety from renal labeling alone.

Before prescribing

Confirm indication and treatment phase, weight, CBC, kidney/liver function, bleeding history, pregnancy and all interacting drugs. Review antiplatelets/NSAIDs and Paxlovid. Mechanical valves, significant rheumatic mitral stenosis and high-risk antiphospholipid syndrome require a different anticoagulation strategy. Confirm hemodynamic stability, outpatient suitability and any anticoagulant already received; unstable PE needs emergency care.

Side effects and return precautions

Bleeding and premature interruption are the major preventable harms. Provide clear head-injury and GI-bleeding instructions. Coordinate surgery, neuraxial procedures and any temporary interruption; bridging or stopping is not an automatic patient decision.

Follow-up

Confirm access, adherence and the day-eight dose change within the first week. Review bleeding, CBC and kidney/liver function according to risk; document the planned treatment duration and reassess before stopping. New chest pain, breathlessness or fainting requires emergency assessment.

Sources

Checked September 22, 2026.

Apixaban (Eliquis)Extended prevention after DVT or PE

What to say

You’ve completed at least six months of treatment for the clot. We’ve decided that continuing protection makes sense for you, at apixaban 2.5 milligrams twice daily. This lower dose helps prevent another clot. It isn’t the starting treatment for a new one. Take it morning and evening. If you miss a dose, take it when remembered that day without doubling. Don’t stop it or interrupt it for a procedure without a plan.

Bruising or minor bleeding can happen. Call the same day about repeated nosebleeds or bleeding that concerns you. Go to the emergency department for vomiting blood, black stools or a head injury. Call 911 for uncontrolled bleeding, fainting, a drooping face, arm weakness or trouble speaking. Check before using aspirin, ibuprofen or new prescriptions. We’ll review you in about a month and monitor blood counts and kidney function. This medicine doesn’t need routine INR testing.

Clinical reference

Dose options

Extended prevention after VTE

2.5 mg twice daily after at least six months of treatment

Duration depends on recurrence and bleeding risks; not the acute-treatment dose.

Interactions and organ impairment

Strong combined CYP3A4/P-gp inhibitors require a 50% reduction of 5 or 10 mg doses; avoid if already taking 2.5 mg twice daily

Avoid strong inducers. Severe liver disease is not recommended. Trials did not establish outcomes for CrCl <15/dialysis; individualize rather than infer safety from renal labeling alone.

Before prescribing

Confirm indication and treatment phase, weight, CBC, kidney/liver function, bleeding history, pregnancy and all interacting drugs. Review antiplatelets/NSAIDs and Paxlovid. Mechanical valves, significant rheumatic mitral stenosis and high-risk antiphospholipid syndrome require a different anticoagulation strategy.

Side effects and return precautions

Bleeding and premature interruption are the major preventable harms. Provide clear head-injury and GI-bleeding instructions. Coordinate surgery, neuraxial procedures and any temporary interruption; bridging or stopping is not an automatic patient decision.

Follow-up

Periodically reassess recurrence risk, bleeding, preferences and continued need. Monitor CBC and kidney/liver function at least annually, sooner with CKD, frailty, illness or bleeding. New symptoms of DVT/PE require assessment rather than self-increasing the dose.

Sources

Checked September 22, 2026.

Aripiprazole (Abilify)Bipolar I disorder, manic or mixed episodes

What to say

We’re using aripiprazole to treat the manic symptoms of bipolar disorder, such as racing thoughts, unusually high energy and needing much less sleep. In this plan, take 15 milligrams once daily. We’ll keep close track of your sleep, mood and decisions with [treating team].

Tell us promptly about a feeling that you can’t sit still, new involuntary movements, or hard-to-control urges to gamble, spend, eat or have sex. These need review even if they seem like part of the mood episode. We’ll also monitor weight, blood sugar and cholesterol.

Contact the team urgently for worsening sleeplessness or risky behavior. If you can’t stay safe, seek emergency care. Fever with severe stiffness or confusion also needs emergency care. Follow the written medication plan and check with us before changing it.

Clinical reference

Dose options

Adult mania / mixed episode: monotherapy

Start / target 15 mg orally once daily

Maximum 30 mg/day, based on response.

With lithium or valproate

Start 10–15 mg daily; target 15 mg; maximum 30 mg/day

Coordinate the complete regimen and interaction adjustments with psychiatry.

  • This regimen treats mania or mixed episodes, not bipolar depression. Oral tablets and long-acting injections have different schedules.

Before prescribing

Confirm episode type, suicide risk, substance use, pregnancy context and care setting. Check weight/BMI, BP/pulse, glucose/HbA1c, lipids and movements. Review CYP2D6/CYP3A4 interactions and known poor-metabolizer status against label section 2.6.

Side effects and return precautions

Akathisia, tardive dyskinesia, metabolic changes and compulsive urges require review. Unsafe mania needs urgent specialist assessment. Not approved for dementia-related psychosis; increased mortality warning applies.

Follow-up

Arrange close psychiatric follow-up during the episode. NICE: weight/BMI weekly for 6 weeks and at 12 weeks; glucose/HbA1c and lipids at 12 weeks. Monitor BP/pulse after dose changes; agree ongoing physical-health monitoring and the longer-term treatment plan.

Sources

Checked September 22, 2026.

Aripiprazole (Abilify)Depression, add-on to an antidepressant

What to say

We’re adding aripiprazole to help with depression that hasn’t improved enough on your antidepressant. Start 2 milligrams once daily, with or without food, and continue your antidepressant as prescribed. We’ll review your mood, daily functioning and side effects before changing the dose.

Contact us promptly if you feel unable to sit still, develop new uncontrolled movements, or notice urges to gamble, shop, eat or have sex that are hard to control. It can affect sleep, weight and blood sugar. Avoid driving until you know how it affects you.

Get urgent help for new suicidal thoughts. Call 911 if you might act on them or can’t stay safe. Fever with marked muscle stiffness or confusion needs emergency care. Don’t change or stop the medicine on your own. Our first check-in is [date].

Clinical reference

Dose options

Adult depression: add-on start

2–5 mg orally once daily

The wording above uses 2 mg. Use with an antidepressant.

Titration / limit

Recommended target 5–10 mg/day; maximum 15 mg/day

Increase by no more than 5 mg at intervals of at least one week; use the lowest effective dose.

  • Oral-tablet regimen only. Long-acting injections have separate indications and schedules.

Before prescribing

Confirm unipolar depression, adequate prior treatment, suicide risk and pregnancy context. Record weight, BP/pulse, glucose or HbA1c, lipids and baseline movements. Reconcile interactions; section 2.6 of the label includes specific instructions for adjunctive depression.

Side effects and return precautions

Assess akathisia, involuntary movements, metabolic effects and compulsive urges. Monitor worsening mood, especially in younger adults. Boxed warning includes increased mortality in older adults with dementia-related psychosis; not approved for that use.

Follow-up

Arrange early review, within one week when suicide risk warrants. NICE: weight weekly for 6 weeks, then at 12 weeks, 1 year and annually; glucose/HbA1c and lipids at 12 weeks, 1 year and annually. Review benefit and continued need with mental-health support.

Sources

Checked September 22, 2026.

Aripiprazole (Abilify)Schizophrenia

What to say

Aripiprazole can help reduce symptoms such as hearing voices and feeling threatened, and help you work toward [personal goal]. For this plan, take 10 milligrams once daily. Improvement can take several weeks. We’ll review how you’re feeling and functioning with [mental-health team].

Tell us promptly if you can’t sit still, notice movements you can’t control, or develop strong urges to gamble, shop, eat or have sex. Dizziness or sleepiness can happen. We’ll check your weight and blood tests as well as how the medicine is helping.

If symptoms worsen, contact [team and number]. If voices tell you to hurt yourself or someone else, seek urgent help. Call 911 if you might act on them or can’t stay safe. Fever with severe stiffness or confusion needs emergency care. Discuss medication changes with the team, even when you feel better.

Clinical reference

Dose options

Adult oral start / target

10–15 mg once daily; maximum 30 mg/day

The wording above uses 10 mg. Higher doses were not more effective than 10–15 mg in trials.

Titration

Generally wait at least 2 weeks before increasing

Individualize any switch from another antipsychotic.

  • Oral tablets only. Long-acting aripiprazole products require their own initiation and maintenance plans.

Before prescribing

Confirm diagnosis, risk, substance use and pregnancy context. Record weight, waist, BP/pulse, glucose/HbA1c, lipids, prolactin and movements; ECG when indicated. Check CYP2D6/CYP3A4 interactions and poor-metabolizer dosing in label section 2.6.

Side effects and return precautions

Review akathisia, involuntary movements, metabolic effects and compulsive urges. Reassess worsening psychosis or self-neglect. Not approved for dementia-related psychosis; increased mortality warning applies.

Follow-up

Agree early symptom/safety review and a crisis plan. NICE: weight weekly for 6 weeks; weight, BP/pulse, glucose/HbA1c and lipids at 12 weeks, 1 year and annually. Psychiatry retains monitoring responsibility for at least 12 months or until stable, whichever is longer.

Sources

Checked September 22, 2026.

Aspirin 81 mg (Bayer Low Dose)Deciding about primary prevention, off-label

What to say

If you haven’t had a heart attack, stroke, stent or blocked leg arteries, daily aspirin isn’t right for most people. The protection is small, and the risk of bleeding in the stomach or brain is real. At ages 40 to 59 with higher heart risk and no bleeding problems, it can be a personal choice; at 60 or older, we don’t start it. Using aspirin this way is off-label. If we decide on it together, take 81 milligrams once a day.

If you’ve had a heart attack, stroke or stent, this advice doesn’t apply; don’t stop aspirin without talking with us. If you take it only for prevention, let’s review it; we usually consider stopping around age 75. Check with us before surgery or adding ibuprofen, naproxen or another blood thinner. Go to the emergency department for black or bloody stools or vomiting blood. Call 911 for a sudden severe headache, bleeding that won’t stop or stroke symptoms.

Clinical reference

Dose options

Ages 40–59 with 10-year CVD risk ≥10% and no increased bleeding risk

81 mg orally once daily, only if chosen through shared decision-making

USPSTF 2022 grade C. The 2019 ACC/AHA guideline says 75–100 mg might be considered at ages 40–70 (Class 2b). Not an FDA-labeled indication.

Age ≥60 (USPSTF) or >70 (ACC/AHA), or increased bleeding risk

Do not start

Current primary-prevention users: consider stopping around age 75. Secondary prevention after MI, stroke, stents or PAD follows a different plan.

  • Off-label: FDA professional labeling covers secondary vascular indications only (ischemic stroke/TIA, MI, angina, revascularization), not primary prevention.

Before prescribing

Confirm no ASCVD (MI, stroke/TIA, stents, PAD) or other antiplatelet indication. Estimate 10-year CVD and bleeding risk: prior GI bleed or ulcer, thrombocytopenia, coagulopathy, CKD, anticoagulants, NSAIDs, steroids. Ask about aspirin allergy or asthma.

Side effects and return precautions

GI bleeding and intracranial hemorrhage are the main harms and rise with age. Bruising and dyspepsia are common; watch for bronchospasm in aspirin-sensitive asthma.

Follow-up

Revisit the decision with any new bleeding risk, anticoagulant or ASCVD event, and around age 75. Coordinate procedure holds; secondary-prevention aspirin shouldn’t be stopped without a plan.

Sources

Checked October 15, 2026.

Aspirin 81 mg (Bayer Low Dose)Secondary prevention in coronary artery disease

What to say

Because you already have disease in your heart’s arteries, we’re using aspirin 81 milligrams once daily to reduce the chance of a heart attack. Take it at the same time each day. It helps keep platelets from sticking together, so bruising and bleeding can happen.

Go to the emergency department for black, sticky stools or vomiting blood. Call 911 for heavy bleeding that won’t stop, a drooping face, arm weakness, trouble speaking, or severe weakness or fainting with bleeding. Call us the same day for repeated nosebleeds or new blood in the urine. Check with us before adding ibuprofen, naproxen or another blood thinner. Don’t stop aspirin for a procedure on your own, especially if you have a heart stent. We’ll coordinate the plan. We’ll review bleeding and your other medicines at follow-up.

Clinical reference

Dose options

Chronic coronary disease without an oral-anticoagulant indication

81 mg orally once daily; guideline range 75–100 mg/day

Confirm the actual antithrombotic indication and regimen.

After stenting / alongside anticoagulation

Duration and combination depend on ischemic and bleeding risk

Do not automatically add indefinite aspirin to apixaban or another anticoagulant.

Primary prevention

Not a routine daily recommendation for all adults

A separate, individualized decision; the wording above covers secondary prevention only.

Before prescribing

Review aspirin allergy/respiratory reactions, ulcer or bleeding history, anticoagulants, other antiplatelets and NSAIDs. Enteric coating does not eliminate bleeding risk.

Side effects and return precautions

Bruising, GI bleeding and rare intracranial bleeding. Ibuprofen may interfere with antiplatelet effect as well as increase bleeding risk.

Follow-up

Confirm tolerance and the intended combination/duration at the next visit; reassess sooner for bleeding or before procedures.

Sources

Checked September 20, 2026.

Aspirin with clopidogrelShort-term treatment after minor stroke or high-risk TIA, off-label

What to say

After a minor stroke or TIA, the risk of another stroke is highest in the next few weeks. Taking 2 antiplatelet medicines together for a short time lowers that risk. Stroke guidelines recommend this off-label combination. Take clopidogrel 75 milligrams and aspirin 81 milligrams once a day until [date], 21 days after you started. Then stop [aspirin or clopidogrel] and keep taking [the other] every day. Staying on both longer raises bleeding risk.

Bruising and nosebleeds are more likely. Call us the same day for repeated bleeding or blood in your urine. Go to the emergency department for black or bloody stools or vomiting blood. Call 911 for bleeding that won’t stop, a sudden severe headache, or new face drooping, arm weakness, trouble speaking or vision loss, even if it goes away. Use acetaminophen for pain, not ibuprofen or naproxen. Ask before taking omeprazole or esomeprazole, and don’t stop either medicine early on your own.

Clinical reference

Dose options

Day 1 loading, usually in the ED or hospital

Clopidogrel 300–600 mg once plus aspirin (trials used 50–325 mg), ideally within 12–24 hours of onset

CHANCE used 300 mg and POINT 600 mg. The Plavix label’s recent-stroke regimen is 75 mg daily without a load; this DAPT regimen is guideline-based.

Days 2–21

Clopidogrel 75 mg plus aspirin 81 mg once daily, then a single antiplatelet agent long term

AHA/ASA 2021 (Class 1): noncardioembolic minor stroke (NIHSS ≤3) or high-risk TIA (ABCD2 ≥4), for 21–90 days. The 2026 acute stroke guideline uses 21 days and also allows NIHSS 4–5 and starting up to 72 hours after onset.

Alternative chosen by the stroke team

Ticagrelor plus aspirin for 30 days (THALES, NIHSS ≤5)

Class 2b alternative; a 21-day ticagrelor–aspirin course is an option for CYP2C19 loss-of-function carriers. Not for patients who need anticoagulation, such as cardioembolic stroke from AF.

Before prescribing

Confirm imaging excluded hemorrhage, a noncardioembolic mechanism, eligibility (NIHSS/ABCD2), no recent IV thrombolysis, no anticoagulant indication, bleeding history, CBC and PPI use. Write the stop date and which agent continues.

Side effects and return precautions

Bleeding, including GI and intracranial; bruising and epistaxis. New stroke or TIA symptoms need 911. Rare TTP with clopidogrel. NSAIDs, SSRIs and anticoagulants add bleeding risk.

Follow-up

Confirm the day-21 switch to one antiplatelet agent and which one continues. Review at 2–4 weeks with BP, lipids, diabetes, rhythm monitoring and vascular imaging results; arrange neurology follow-up.

Sources

Checked October 15, 2026.

Atenolol (Tenormin)Hypertension

What to say

Atenolol, a beta-blocker, lowers blood pressure by slowing your heart and easing how hard it pumps. Take it once a day, usually 25 to 50 milligrams, up to 100 milligrams. Your kidneys clear it, so we may use a lower dose if kidney function is reduced. For high blood pressure alone, other medicines are usually preferred first, so we’ll review whether it’s still the best fit for you.

You may feel tired or dizzy, or notice cold hands and feet; get up slowly. Don’t stop it suddenly, which can trigger chest pain, a fast heartbeat or a heart attack; we’ll taper it if needed. Call us for a pulse under 50 with dizziness, new wheezing, or swelling with shortness of breath. Call 911 for fainting or chest pain. If you use insulin or glipizide, it can hide the racing heart of low blood sugar.

Clinical reference

Dose options

Hypertension

Start 25–50 mg once daily; may increase to 100 mg once daily after 1–2 weeks

Label start is 50 mg (25 mg for some older or renally impaired patients); doses above 100 mg add no benefit. 2025 AHA/ACC: beta-blockers aren’t first-line without a compelling indication.

Renal impairment

CrCl 15–35: max 50 mg daily. CrCl <15: max 25 mg daily. Hemodialysis: 25–50 mg after each dialysis

No significant accumulation until CrCl <35 mL/min/1.73 m². Dose after dialysis under supervision because marked hypotension can occur.

Before prescribing

Contraindicated: sinus bradycardia, heart block greater than first degree, cardiogenic shock, overt heart failure. Caution: asthma/COPD, diabetes, untreated pheochromocytoma, PAD, verapamil/diltiazem, clonidine. Check eGFR and pregnancy (fetal growth restriction).

Side effects and return precautions

Bradycardia, fatigue, dizziness, cold extremities, bronchospasm, HF decompensation; masks tachycardia of hypoglycemia or thyrotoxicosis. Abrupt cessation: angina, MI, ventricular arrhythmias.

Follow-up

Recheck BP and heart rate in 2–4 weeks and after dose changes. In uncomplicated hypertension not at goal, consider switching to a first-line class; taper over 1–2 weeks when stopping.

Sources

Checked October 15, 2026.

Atogepant (Qulipta)Migraine prevention

What to say

Atogepant is a daily tablet to prevent migraines. Take [dose, usually 60 milligrams] once a day, with or without food. Some medicines and severe kidney disease call for a lower dose. It won’t stop an attack that has already started, so keep your plan for attacks. Keep a headache diary; we’ll judge how well it’s working after 8 to 12 weeks.

Nausea, constipation and tiredness are the most common side effects, and some people lose appetite or weight. Check your blood pressure in the first week and tell us if it’s higher than usual. Fingers or toes that turn white or blue and hurt mean stop it and call us. Call 911 for face or throat swelling or trouble breathing, which can start days after a dose. Check with us before starting antibiotic, antifungal, HIV or seizure medicines, and tell us if you could be pregnant.

Clinical reference

Dose options

Episodic or chronic migraine

Episodic: 10, 30 or 60 mg orally once daily; chronic: 60 mg once daily

2026 AAN/AHS: a higher-confidence option for episodic and chronic migraine and for patients with medication overuse. Judge efficacy after 8–12 weeks at a tolerated dose.

Interactions

Strong CYP3A4 inhibitors: 10 mg daily. OATP inhibitors (e.g., cyclosporine): episodic 10 or 30 mg; chronic 30 mg

Strong/moderate CYP3A4 inducers: episodic 60 mg, chronic not recommended. Weak inducers (e.g., topiramate): episodic 30 or 60 mg, chronic 60 mg. No change for moderate/weak CYP3A4 inhibitors.

Renal / hepatic

CrCl <30 mL/min, including ESRD: episodic 10 mg daily (after dialysis); chronic not recommended

Avoid in severe hepatic impairment (Child-Pugh C). No adjustment for mild–moderate renal or hepatic impairment.

Before prescribing

Offer prevention for ≥4 migraine days a month or disabling migraine. Check BP and hypertension history, Raynaud phenomenon, CYP3A4/OATP drugs, CrCl, severe hepatic impairment, pregnancy plans, prior hypersensitivity and prior authorization.

Side effects and return precautions

Nausea, constipation, fatigue, decreased appetite; ≥7% weight loss in 5.3% at 60 mg (2.5% placebo). New or worsened hypertension, often within 7 days; Raynaud phenomenon; delayed hypersensitivity; rare asymptomatic transaminase rises.

Follow-up

Check BP within 1–2 weeks. Review the diary at 8 weeks; judge efficacy at 8–12 weeks and switch if still suboptimal by 12–24 weeks. Discuss tapering after 6 months of good control.

Sources

Checked October 15, 2026.

Atomoxetine (Strattera)ADHD

What to say

I’m starting atomoxetine 40 milligrams each morning for ADHD. Take the capsule whole, with or without food. Unlike a stimulant, its benefit builds over several weeks, so take it every day. After one week, we’ll check how you’re tolerating it before moving toward 80 milligrams. Some medicines require us to increase it more slowly.

Nausea, dry mouth, lower appetite, and changes in sleep or sexual function can happen. Go to the emergency department if you can’t pass urine. Call the same day for a major mood change or thoughts of harming yourself. Call 911 if you can’t stay safe. Stop it and call the same day for yellow skin or eyes or dark urine, which can signal liver trouble. Call 911 for chest pain or fainting. We’ll review your blood pressure, pulse, weight, side effects, and progress during titration. Don’t open capsules or take extra doses to speed the benefit.

Clinical reference

Dose options

Adult start / target

40 mg/day; increase after ≥3 days to 80 mg/day if tolerated

May give each morning or divide evenly morning/late afternoon. The wording above waits a week for a tolerability review. Swallow capsules whole.

Further titration / CYP2D6

After 2–4 additional weeks at 80 mg, may increase to maximum 100 mg/day

With a strong CYP2D6 inhibitor or poor-metabolizer status, wait 4 weeks before increasing if response is inadequate and tolerance good. Consider genotype when relevant per current label.

Hepatic / renal

Child-Pugh B: use 50% of usual initial/target doses; C: 25%; A: usual doses

Usual renal dosing, including ESRD, but monitor BP. No taper is required by label for discontinuation.

Before prescribing

Check BP/pulse/weight, cardiovascular and bipolar history and fluoxetine/paroxetine/bupropion interactions. Contraindications include severe cardiovascular disease, narrow-angle glaucoma, pheochromocytoma and MAOIs within 14 days. Review pregnancy plans.

Side effects and return precautions

Pediatric suicidal-ideation boxed warning is not an adult risk estimate; monitor mood in all patients. Stop for suspected liver injury; do not restart if jaundice/laboratory injury confirmed. Urinary retention and priapism need urgent evaluation; erection ≥4 hours is an emergency.

Follow-up

Assess tolerability within 1–2 weeks and benefit over subsequent weeks. BP/pulse at dose changes and at least every 6 months, adult weight every 6 months. Obtain liver tests for concerning symptoms rather than automatic routine screening.

Sources

Checked September 20, 2026.

Atorvastatin (Lipitor)Cholesterol lowering and cardiovascular prevention

What to say

Based on your cholesterol and overall heart and stroke risk, I recommend atorvastatin 20 milligrams once daily. You can take it with or without food, at a time you’ll remember. This is prevention, so you’ll probably not feel a day-to-day benefit.

Let me know about new muscle aches, especially if they persist. Severe muscle pain or weakness with dark urine means stop the medicine and go to the emergency department. Check with your pharmacist before new medicines or supplements, because some combinations need adjustment. We’ll repeat cholesterol in about six to eight weeks and discuss both the response and how you feel taking it. If you become pregnant, stop atorvastatin and contact us promptly. We would make a different plan in advance if your cardiovascular risk requires an exception.

Clinical reference

Dose options

Moderate-intensity range

10–20 mg orally once daily

Choose from baseline risk and intended LDL reduction.

High-intensity range

40–80 mg once daily

40 mg is a label-supported start when a large LDL reduction is needed.

Maximum / adjustments

80 mg daily; no renal dose adjustment

Interaction-specific dose limits may be lower. Acute liver failure/decompensated cirrhosis contraindicates use.

Before prescribing

Check lipids, liver history, interacting drugs, pregnancy plans and myopathy risks. Consider liver enzymes before starting; do not order routine CK without a reason. Most pregnant patients stop; exceptional very-high-risk cases need specialist planning.

Side effects and return precautions

Common: muscle symptoms or GI upset. Important: myopathy/rhabdomyolysis and liver injury. Discuss pregnancy and breastfeeding explicitly rather than presenting a class-wide risk-free statement.

Follow-up

Lipids about 4–12 weeks after initiation/change; review adherence and tolerability. Liver tests when clinically indicated. Current Lipitor instructions: skip a missed dose, resume usual schedule, do not double.

Sources

Checked September 20, 2026.

Atovaquone/proguanil (Malarone)Malaria prevention

What to say

To prevent malaria, take one adult tablet of atovaquone-proguanil daily, at the same time, with food or a milky drink. Start 1–2 days before you enter the malaria area, take it daily while there, and continue for 7 days after you leave. If you vomit within an hour, take another tablet. If you miss a dose, take it with food as soon as you can; don’t double up. No medicine fully prevents malaria, so also use insect repellent, cover up and sleep under a net where advised.

Nausea, headache, mouth sores or vivid dreams can happen. Stop it and get emergency care for trouble breathing, facial swelling, or a blistering or peeling rash. Get same-day care for yellow skin or eyes. Tell us if you take warfarin, rifampin or metoclopramide, or could be pregnant. Fever during the trip or in the months after needs same-day care and a malaria test, even if you took every dose; say where you traveled.

Clinical reference

Dose options

Adult prophylaxis

1 adult tablet (atovaquone 250 mg/proguanil 100 mg) daily with food or a milky drink, from 1–2 days before entry until 7 days after leaving

Repeat the dose if vomiting occurs within 1 hour. Dispense days in the risk area plus 9 tablets. Do not use atovaquone-proguanil as standby treatment while taking it as prophylaxis.

Renal function, pregnancy and lactation

Contraindicated for prophylaxis at CrCl <30 mL/min

No adjustment for CrCl 30–80. CDC: not recommended in pregnancy or while breastfeeding an infant <5 kg.

Before prescribing

Check the itinerary against current CDC destination guidance, CrCl, pregnancy/breastfeeding and prior serious skin reaction. Interactions: warfarin (monitor INR), rifampin/rifabutin (avoid), metoclopramide, tetracycline. Start ≥10 days after the last oral Ty21a typhoid capsule.

Side effects and return precautions

Abdominal pain, nausea, vomiting, headache, oral ulcers, vivid dreams. Rare hepatitis, SJS/DRESS, seizures, psychiatric effects, cytopenias. Fever during or after travel needs prompt malaria testing despite prophylaxis.

Follow-up

Document start and stop dates, including 7 days after leaving. If switching antimalarials or starting late, follow CDC switching rules (may require 4 weeks after leaving). Reassess if the itinerary or pregnancy status changes.

Sources

Checked October 15, 2026.

Azelaic acid 15% gel (Finacea)Rosacea

What to say

For the red bumps and pimples of rosacea, apply a thin layer of azelaic acid 15% gel to the affected areas of your face twice a day, morning and evening. Wash first with a mild, soap-free cleanser and pat dry. Wash your hands afterward. Makeup is fine once it dries, but don’t cover it with bandages. It takes several weeks to help, so we’ll review it at 12 weeks.

Burning, stinging, tingling or itching are common in the first few weeks and usually settle. Keep it away from your eyes, mouth and nostrils. If it gets in your eyes, rinse with plenty of water. Stop it and call us if irritation is severe or doesn’t ease. Tell us about lighter patches of skin, especially if you have darker skin, or if your asthma worsens. Daily sunscreen and gentle skin care help control rosacea.

Clinical reference

Dose options

Papulopustular rosacea

15% gel, thin layer twice daily (morning and evening)

Reassess the diagnosis if not improved after 12 weeks. Avoid occlusive dressings.

Before prescribing

Confirm papulopustular rosacea rather than acne, perioral dermatitis or steroid-induced rosacea. Ask about asthma and eye symptoms; plan to monitor darker skin for hypopigmentation.

Side effects and return precautions

Burning, stinging, pruritus early; contact dermatitis. Hypopigmentation and vitiligo-like depigmentation reported; asthma worsening; eye irritation after accidental exposure.

Follow-up

Review at 12 weeks and continue if effective. Add or switch to ivermectin, metronidazole or oral therapy if inadequate; assess ocular rosacea symptoms.

Sources

Checked October 15, 2026.

Azelastine nasal spray (Astepro)Allergic rhinitis

What to say

Azelastine is an antihistamine nose spray for sneezing, runny nose and congestion from allergies. The over-the-counter Astepro Allergy dose is 1–2 sprays in each nostril every 12 hours, or 2 sprays in each nostril once a day, with no more than 4 sprays per nostril in 24 hours. Prime it before first use and after 3 or more days unused. Tilt your head down while spraying to avoid a bitter taste, and keep it out of your eyes.

It can cause a bitter taste, drowsiness, and brief nasal discomfort or sneezing. Avoid alcohol and sedatives, and be careful driving until you know how it affects you. Ask us first if you have recent nose ulcers, nose surgery or an unhealed nose injury. Stop it and call us for a rash or severe or frequent nosebleeds. If it isn’t enough, adding a steroid spray such as fluticasone can help.

Clinical reference

Dose options

OTC azelastine 0.15% (Astepro Allergy; 205.5 mcg/spray)

Age 12 and older: 2 sprays per nostril once daily, or 1–2 sprays per nostril every 12 hours; maximum 4 sprays per nostril/24 hours

Ages 6–11: 1 spray per nostril every 12 hours with adult supervision; not under 6. Prime before first use and when unused for 3 or more days.

Prescription azelastine 0.1% (137 mcg/spray)

Seasonal allergic rhinitis, age 12 and older: 1–2 sprays per nostril twice daily; vasomotor rhinitis: 2 sprays per nostril twice daily

Prime 4 sprays; reprime 2 sprays after 3 or more days unused. Rhinitis guideline supports an intranasal antihistamine as first-line monotherapy for nonallergic rhinitis.

Azelastine plus fluticasone (Dymista)

1 spray per nostril twice daily (137 mcg azelastine and 50 mcg fluticasone)

Labeled for seasonal allergic rhinitis, age 6 and older. Prime 6 sprays; reprime 1 spray after 14 or more days. Use when a steroid spray alone is inadequate.

  • The 2020 practice parameter supports combining an intranasal steroid with an intranasal antihistamine in allergic and nonallergic rhinitis, and limits intranasal decongestants to short-term use.

Before prescribing

Confirm rhinitis rather than infection. Avoid with recent nasal ulcers, surgery or unhealed injury. Review alcohol, sedatives, driving and shift work. Intranasal steroid is usually preferred for persistent allergic rhinitis; check pregnancy and breastfeeding.

Side effects and return precautions

Bitter taste, somnolence, nasal burning, epistaxis. Stop for rash or severe or frequent nosebleeds; look for septal injury if bleeding persists.

Follow-up

Review control after a trial of regular use. Add or switch to an intranasal steroid if response is inadequate; consider allergy testing or immunotherapy for persistent symptoms.

Sources

Checked October 15, 2026.

Azithromycin (Zithromax, Z-Pak)Pneumonia

What to say

For the pneumonia we’ve assessed for treatment at home, the azithromycin plan is 500 milligrams on day one, then 250 milligrams once a day on days two through five. Take the tablets with or without food. Check the tablet strength so the first day’s dose is correct. If we have prescribed a second antibiotic, take it on its own written schedule too.

Nausea, loose stools and stomach discomfort can happen. Let’s know if you’re getting worse or haven’t started improving within two to three days. Stop and get same-day advice for yellow eyes or skin, or severe diarrhea. For a new racing or irregular heartbeat, get same-day urgent medical care. Fainting, chest pain or severe breathing trouble means call 911.

Clinical reference

Dose options

Susceptible respiratory infection

500 mg orally on day 1, then 250 mg daily on days 2–5

Specify the diagnosis. For outpatient CAP, macrolide monotherapy is limited to suitable patients where local pneumococcal resistance is <25%.

Other infections

Regimen depends on diagnosis; a Z-Pak is not a universal antibiotic course

Do not routinely use for bacterial sinusitis because of resistance; gonorrhea and other STIs require their current guideline regimens.

Organ function / cardiac risk

Use caution in severe renal impairment and hepatic disease

No routine mild/moderate renal adjustment; QT risk and drug interactions may rule out use.

Before prescribing

Confirm a susceptible bacterial indication and severity; review QT prolongation, bradycardia, potassium/magnesium, other QT drugs, myasthenia gravis and previous azithromycin liver injury.

Side effects and return precautions

GI effects, liver injury, QT arrhythmia and antibiotic-associated diarrhea. Severe allergy or blistering/mucosal rash: stop and emergency assessment.

Follow-up

Reassess worsening or nonresponse within 48–72 hours according to infection. Do not repeat a Z-Pak without reconsidering diagnosis and resistance.

Sources

Checked September 20, 2026.

Azithromycin (Zithromax)Chlamydia in pregnancy

What to say

We’ve chosen azithromycin to treat chlamydia during pregnancy. Take one gram (1,000 milligrams) by mouth once, with or without food. This is a single treatment dose, not the five-day Z-Pak schedule. If you vomit within an hour, call us before taking more.

Avoid sex for seven days after the dose and until your partners have completed treatment and symptoms have resolved. We’ll repeat testing in about four weeks to confirm the infection cleared, and again in three months. Nausea or diarrhea can happen. Get prompt advice for severe diarrhea, a new rash, yellow skin or eyes, or palpitations. Fainting or breathing trouble needs emergency care.

Clinical reference

Dose options

Chlamydia in pregnancy

1 g orally once

CDC-recommended pregnancy regimen; confirm the supplied tablet strength or suspension instructions.

Before prescribing

Check macrolide allergy, prior azithromycin liver injury, QT risk and interacting drugs. Arrange other STI testing and partner treatment.

Side effects and return precautions

Persistent pelvic pain, fever or worsening symptoms needs prompt reassessment. Do not automatically repeat a dose after vomiting.

Follow-up

Pregnancy: NAAT test of cure about 4 weeks after therapy, retest at 3 months and repeat in the third trimester when indicated by risk.

Sources

Checked September 23, 2026.

Azithromycin (Zithromax)Travelers’ diarrhea, off-label

What to say

This is a standby antibiotic for travelers’ diarrhea, an off-label use of azithromycin. Mild diarrhea usually needs only fluids. Take it only if diarrhea is severe, keeps you from your plans, or comes with fever or blood in the stool: 1,000 milligrams, two 500-milligram tablets, once, with or without food. If you’re not better 24 hours later, take 500 milligrams once a day for up to 2 more days. Drink safe fluids, adding oral rehydration salts for heavy losses.

Nausea and stomach upset are common. You can add loperamide, but don’t use it alone with fever or bloody stools. Get medical care the same day for high fever, ongoing bloody stools, signs of dehydration such as dizziness or very little urine, or no improvement within 24–36 hours. Get emergency care for fainting, chest pain, a racing or irregular heartbeat, trouble breathing or facial swelling. Tell us now about any heart rhythm problems or medicines that affect heart rhythm.

Clinical reference

Dose options

Standby treatment, moderate to severe travelers’ diarrhea

1,000 mg orally once (may be split into 2 doses the same day)

If symptoms persist after 24 hours, continue 500 mg daily for up to 3 days in total (CDC, ISTM). The single 1-g dose causes more nausea. Not an FDA-labeled indication.

Alternative course

500 mg orally once daily for 3 days

Azithromycin is preferred for dysentery, febrile diarrhea and South or Southeast Asia (fluoroquinolone-resistant Campylobacter). Antibiotics are not recommended for mild TD and are optional for moderate TD.

Adjuncts

Loperamide 4 mg, then 2 mg after each loose stool (maximum 16 mg/24 h); oral rehydration solution for significant losses

Loperamide may be combined with the antibiotic; avoid loperamide alone with bloody or febrile diarrhea.

  • Off-label in the US; CDC and ISTM guidance support azithromycin as the preferred standby agent for dysentery, febrile diarrhea and South or Southeast Asia travel.

Before prescribing

Confirm itinerary and access to care, macrolide allergy, prior azithromycin cholestatic jaundice, QT prolongation or QT-prolonging drugs, bradycardia, low potassium/magnesium, myasthenia gravis and warfarin. Counsel that mild TD needs fluids, not antibiotics.

Side effects and return precautions

Nausea/vomiting (more with 1 g), abdominal pain, loose stools. Rare QT arrhythmia, hepatotoxicity, severe hypersensitivity (SJS/TEN/DRESS) and C. difficile infection, including weeks after use.

Follow-up

No improvement within 24–36 hours of self-treatment needs medical care. Returning travelers with severe or persistent (≥2 weeks) diarrhea, or treatment failure, need stool testing.

Sources

Checked October 15, 2026.

Baloxavir (Xofluza)Flu prevention after exposure

What to say

We’ve chosen baloxavir to lower your chance of flu after this exposure. Take the prescribed [40 / 80] milligrams once, within 48 hours of contact. The dose depends on your weight. This is for prevention while you don’t have symptoms.

Take it with water. Avoid taking it together with dairy, calcium-fortified drinks, antacids or mineral supplements. If flu symptoms develop, call promptly rather than taking another dose yourself. One dose doesn’t provide ongoing seasonal protection or replace vaccination. Let’s know about further exposure so we can reassess the plan.

Clinical reference

Dose options

Adult single oral dose

Weight 20 to <80 kg: 40 mg once; ≥80 kg: 80 mg once

This entry uses tablets for adults ≥20 kg. Lower weights require the product-specific suspension regimen.

Before prescribing

Confirm weight, timing, uncomplicated illness/exposure, allergy and interacting minerals. CDC does not recommend use during pregnancy or breastfeeding, in immunocompromised patients, or for complicated/progressive or hospitalized flu. Severe renal impairment is insufficiently studied.

Side effects and return precautions

Diarrhea or nausea may occur. Serious allergy, facial swelling or a severe rash needs urgent assessment. New confusion, chest pain or breathing difficulty can signal complicated influenza.

Follow-up

Monitor for symptoms and reassess continuing/repeated exposure. Review timing of live intranasal flu vaccine. Do not automatically repeat a single-dose prophylaxis course.

Sources

Checked September 23, 2026.

Baloxavir (Xofluza)Flu treatment

What to say

We’ve chosen a single dose of baloxavir for your flu. Take the prescribed [40 / 80] milligrams once today. The dose depends on your weight. It should be taken within 48 hours of symptoms starting. It can shorten the illness, but you may still feel unwell for several days.

Take it with water, with or without food. Don’t take the dose together with dairy, calcium-fortified drinks, antacids or supplements containing minerals such as calcium, iron, magnesium or zinc. Ask the pharmacist about your other medicines. Call if you’re worsening or improve and then become ill again. Severe breathing trouble, chest pain or confusion needs emergency care.

Clinical reference

Dose options

Adult single oral dose

Weight 20 to <80 kg: 40 mg once; ≥80 kg: 80 mg once

This entry uses tablets for adults ≥20 kg. Lower weights require the product-specific suspension regimen.

Before prescribing

Confirm weight, timing, uncomplicated illness/exposure, allergy and interacting minerals. CDC does not recommend use during pregnancy or breastfeeding, in immunocompromised patients, or for complicated/progressive or hospitalized flu. Severe renal impairment is insufficiently studied.

Side effects and return precautions

Diarrhea or nausea may occur. Serious allergy, facial swelling or a severe rash needs urgent assessment. New confusion, chest pain or breathing difficulty can signal complicated influenza.

Follow-up

No routine second dose. Reassess worsening or persistent illness. Review live intranasal flu vaccine timing; treatment is not a substitute for vaccination.

Sources

Checked September 23, 2026.

Bempedoic acid (Nexletol)Cholesterol lowering with statin intolerance

What to say

Bempedoic acid lowers LDL, the bad cholesterol, by reducing how much cholesterol your liver makes. It’s activated mainly in the liver rather than in muscle, one reason it suits people who couldn’t take statins. Take 180 milligrams once a day, with or without food. In a large study of people unable to take statins, it lowered the chance of heart attacks and other heart events. We’ll recheck your cholesterol in 8 to 12 weeks.

It can raise uric acid, so tell us about a gout flare or a hot, swollen joint. Rarely, a tendon can tear. If you feel sudden pain or a snap in your heel, shoulder or upper arm, stop it, rest that area and call us the same day. The risk is higher if you’re over 60, take steroids or antibiotics like ciprofloxacin, or have kidney failure. Higher doses of simvastatin or pravastatin don’t mix well with it. Stop it and tell us if you become pregnant.

Clinical reference

Dose options

LDL lowering and CV risk reduction

180 mg orally once daily, with or without food

Alone or with other LDL-lowering therapy; check lipids 8–12 weeks after starting. Nexlizet is bempedoic acid 180 mg with ezetimibe 10 mg once daily. No renal adjustment.

Interactions

Avoid simvastatin >20 mg/day or pravastatin >40 mg/day

With a fibrate, check TG and HDL-C at 4 weeks and periodically; paradoxical TG rise or HDL-C fall has been reported.

  • 2026 ACC/AHA guideline: Class 1 to add bempedoic acid and/or ezetimibe for statin-attributed muscle symptoms in ASCVD or high-risk primary prevention when LDL-C is above goal.

Before prescribing

Confirm the LDL-C goal, true statin intolerance (rechallenge or low, nondaily dosing tried) and secondary causes of muscle symptoms. Review gout, prior tendon disorder, fluoroquinolone or steroid use, CBC, LFTs, statin dose and pregnancy.

Side effects and return precautions

Hyperuricemia and gout, tendon rupture (rotator cuff, biceps, Achilles), muscle spasms, anemia and low WBC, small creatinine or BUN rise, transaminase elevation and gallstones.

Follow-up

Lipids 8–12 weeks after starting; uric acid, CBC, renal and liver tests as indicated. If LDL-C stays above goal, add ezetimibe or a PCSK9 antibody. Stop for tendon rupture.

Sources

Checked October 15, 2026.

Benzonatate (Tessalon Perles)Cough

What to say

Benzonatate numbs the cough reflex in your airways for a few hours. It doesn’t treat the cause or speed recovery. Take one 100-milligram capsule up to three times a day as needed. Swallow each capsule whole. Never chew, suck or break it: the liquid numbs your mouth and throat, which can cause choking or a severe reaction. If your mouth or throat goes numb, don’t eat or drink until it wears off.

Sleepiness, dizziness, nausea or constipation can happen. Stop it and call us for confusion or seeing things that aren’t there. Keep it locked away: children who swallowed capsules have died within an hour. If a child takes any, call 911. Get seen the same day if you’re short of breath or cough up blood, and contact us for a fever of 104°F or higher or lasting more than five days, or a cough beyond three weeks. Throat tightness, swelling or trouble breathing means call 911.

Clinical reference

Dose options

Adult cough relief

100–200 mg orally three times daily as needed; maximum 200 mg per dose and 600 mg/day

Onset 15–20 minutes; effect lasts 3–8 hours. Swallow whole. Prescribe a small quantity for a short course; skip missed doses rather than doubling.

Before prescribing

Assess cough cause and red flags first (pneumonia, asthma, pertussis, ACE inhibitor, reflux). Check allergy to benzonatate or ester anesthetics (procaine, tetracaine), swallowing difficulty, cognitive impairment, sedatives and children under 10 at home.

Side effects and return precautions

Sedation, dizziness, GI upset; rare confusion or hallucinations. Bronchospasm, laryngospasm or cardiovascular collapse, especially if chewed or sucked. Overdose can cause seizures and cardiac arrest within an hour, even in adults.

Follow-up

Reassess a cough lasting more than 3 weeks or with red flags instead of renewing. Dispense in child-resistant packaging and advise disposal of leftover capsules.

Sources

Checked October 15, 2026.

Benzoyl peroxide (PanOxyl)Acne

What to say

For acne, use a benzoyl peroxide wash, such as PanOxyl, once a day to start. Gently massage it over the whole acne-prone area for 1–2 minutes, then rinse. The first time, test it on 1 or 2 small spots for 3 days. If your skin handles it well, you can use it twice a day. If you also take an antibiotic for acne, keep using benzoyl peroxide with it to help prevent resistance. We’ll check your results in about 12 weeks.

Dryness, peeling and stinging are common. Use a gentle moisturizer, and cut back to every other day if your skin gets irritated. It bleaches hair, towels and colored fabric, so rinse well. Use sunscreen outdoors. Stop it and call us for severe irritation, hives or itching. Call 911 for throat tightness, trouble breathing, fainting, or swelling of your face, lips or tongue.

Clinical reference

Dose options

Wash (e.g., PanOxyl 4% creamy or 10% foaming)

Once daily, increasing to 2–3 times daily if tolerated; massage onto the affected area for 1–2 minutes, then rinse

Per Drug Facts: if dryness or peeling, reduce to once daily or every other day; lower strength or less frequent use reduces irritation. Leave-on gels and creams: thin layer once daily, up to 1–3 times daily.

With acne antibiotics

Pair any oral or topical acne antibiotic with benzoyl peroxide

AAD 2024 good practice: combine systemic antibiotics with BPO and other topicals. NICE advises against topical or oral antibiotic monotherapy; fixed combinations include clindamycin/BPO and adapalene/BPO.

  • FDA testing (March 2025) of 95 BPO acne products found undetectable or extremely low benzene in more than 90%; 6 products were recalled at the retail level. FDA judged the cancer risk very low and advised discarding expired products.

Before prescribing

Do not use with BPO sensitivity or very sensitive skin (Drug Facts). Review other topical irritants (retinoids, salicylic acid), eczema, acne severity and need for combination therapy; topical retinoid or oral tetracycline partners need pregnancy review.

Side effects and return precautions

Dryness, erythema, peeling and burning; allergic contact dermatitis; bleaching of hair and fabric. Rare immediate hypersensitivity (hives, throat tightness, syncope, facial swelling): stop and seek emergency care.

Follow-up

Review response and tolerance at about 12 weeks (NICE); add a retinoid or another mechanism if inadequate. Continue BPO alongside any antibiotic and as maintenance after the antibiotic stops.

Sources

Checked October 15, 2026.

Bictegravir/emtricitabine/tenofovir alafenamide (Biktarvy)HIV post-exposure prophylaxis, off-label

What to say

This is PEP, medicine that lowers your chance of HIV after a possible exposure. Start as soon as possible, ideally within 24 hours and no later than 72 hours. No medicine is FDA-approved for PEP, so this is off-label, but CDC recommends it. Take 1 tablet daily, with or without food, for 28 days without missing doses. Take it 2 hours before or 6 hours after aluminum or magnesium antacids; take calcium or iron supplements with it only alongside food.

Nausea, diarrhea or headache can happen. Tell us about all your medicines, especially dofetilide, rifampin, seizure medicines or St. John’s wort. If you have hepatitis B, stopping can trigger a liver flare. Call us for fever, rash, sore throat, swollen glands or flu-like illness; this can be early HIV. We’ll repeat HIV tests at 4 to 6 weeks and 12 weeks; use condoms until then. With ongoing risk, you can switch straight to PrEP.

Clinical reference

Dose options

nPEP, adults (CDC 2025 preferred regimen)

Bictegravir 50 mg/emtricitabine 200 mg/tenofovir alafenamide 25 mg, 1 tablet daily for 28 days

Start ideally within 24 hours, no later than 72 hours; don’t wait for lab results. Off-label: no drug is FDA-approved for nPEP. Stop early if the source is confirmed HIV-negative.

Renal and hepatic limits

Not recommended if CrCl <30 mL/min (not on dialysis) or Child-Pugh C

Choose another regimen with expert input (CDC PEPline 888-448-4911).

  • CDC 2025: no medication is FDA-approved for nPEP; preferred regimens are BIC/FTC/TAF or dolutegravir plus (TAF or TDF) plus (FTC or 3TC).

Before prescribing

Exposure within 72 hours. Baseline lab HIV Ag/Ab (NAT if long-acting PrEP in 6 months), creatinine/CrCl, ALT/AST, HBV, HCV, STI and pregnancy tests. Dofetilide and rifampin contraindicated; avoid rifabutin, rifapentine, inducer anticonvulsants, St. John’s wort.

Side effects and return precautions

GI upset, headache. Acute HIV symptoms (fever, rash, pharyngitis, lymphadenopathy) need Ag/Ab plus NAT. HBV flare after stopping if HBsAg-positive. Sexual assault: coordinate emergency and forensic care.

Follow-up

Lab HIV Ag/Ab plus NAT at 4–6 weeks and 12 weeks after exposure. With ongoing risk, transition to PrEP without a gap. Vaccinate against hepatitis B if nonimmune.

Sources

Checked October 15, 2026.

Bictegravir/emtricitabine/tenofovir alafenamide (Biktarvy)HIV treatment

What to say

Biktarvy is a complete HIV treatment in one pill, and starting now helps your immune system recover sooner. Take one tablet once a day, with or without food. Missed doses can let HIV become resistant, so set reminders and refill early. We’ll check your viral load in four to eight weeks. Keeping it below 200 copies prevents passing HIV through sex; until then, and for at least six months, use condoms or partner PrEP.

Nausea, diarrhea and headache are usually mild. Take it at least two hours before or six hours after aluminum or magnesium antacids; take calcium or iron at the same time, with food. Never take it with rifampin or dofetilide, and check before new medicines. If you have hepatitis B, stopping it can cause a serious liver flare. Call the same day for yellow eyes, dark urine or a new rash. A blistering rash, mouth sores, or swelling of the face or throat means call 911.

Clinical reference

Dose options

Adults starting ART, including rapid start

1 tablet (bictegravir 50 mg/emtricitabine 200 mg/tenofovir alafenamide 25 mg) orally once daily, with or without food

DHHS AI initial regimen; can start before genotype and HBV results. After CAB-LA PrEP, get an INSTI genotype first or start boosted darunavir with TAF or TDF plus FTC or 3TC while awaiting it.

Renal and hepatic impairment

eCrCl ≥30 mL/min: no adjustment. eCrCl 15–29, or <15 without hemodialysis: not recommended. Child-Pugh C: not recommended

Use with chronic hemodialysis is limited to virologically suppressed adults; give the dose after dialysis.

Polyvalent cations

Al/Mg antacids: Biktarvy ≥2 hours before or 6 hours after. Calcium or iron: take together with food

Avoid routine fasting coadministration with calcium or iron, and dosing with or within 2 hours after Al/Mg antacids.

  • DHHS recommends starting ART immediately or as soon as possible after diagnosis (AII); San Francisco’s citywide RAPID program started more than half of patients on the day of diagnosis.

Before prescribing

Before the first dose, send viral load, CD4, genotype (add integrase after CAB-LA or INSTI-based PEP), hepatitis B serologies, creatinine, urinalysis and pregnancy test. Contraindicated with rifampin or dofetilide; avoid rifabutin, rifapentine, St John’s wort and inducing anticonvulsants; metformin levels rise.

Side effects and return precautions

GI upset, headache, weight gain. Early IRIS, especially with low CD4; HBV flare after stopping; renal injury or Fanconi syndrome, higher risk with NSAIDs or nephrotoxins; rare SJS/TEN or angioedema; lactic acidosis.

Follow-up

Confirm linkage to HIV care and an early return visit. Viral load 4–8 weeks after starting, then every 4–8 weeks until undetectable, then every 3–4 months. Not suppressed by 8–12 weeks: check adherence and repeat genotype. Monitor creatinine and urine protein and glucose.

Sources

Checked October 15, 2026.

Bismuth quadruple therapy (Pylera or separate medicines)H. pylori infection

What to say

This treatment clears H. pylori, a stomach infection that can cause ulcers and cancer. You’ll take an acid reducer, bismuth and two antibiotics for 14 days. With Pylera, take 3 capsules after each meal and at bedtime with a full glass of water, plus omeprazole 20 milligrams 30 to 60 minutes before breakfast and dinner. Separate medicines come with a written schedule. Don’t take doses with milk, antacids, or calcium, iron or zinc.

Bismuth harmlessly turns your tongue and stool black, but black, sticky stool with weakness or dizziness can mean bleeding: go to the emergency department. Nausea, diarrhea and a metallic taste are common. Avoid alcohol until 3 days after finishing, and limit sun. Stop and call the same day for a rash, severe diarrhea, numbness or vision changes; confusion or a seizure needs emergency care. Tell us about pregnancy, warfarin or lithium. Use backup birth control. We’ll retest 4 or more weeks after you finish.

Clinical reference

Dose options

Optimized bismuth quadruple therapy (ACG 2024 first line)

Standard-dose PPI twice daily + bismuth subcitrate 120–300 mg or subsalicylate 300 mg four times daily + tetracycline 500 mg four times daily + metronidazole 500 mg three or four times daily, for 14 days

Separate components are not FDA-approved as a regimen. Don’t substitute doxycycline or use metronidazole below 1.5 g/day (lower cure rates). US bismuth subsalicylate caplets are 262 mg; avoid subsalicylate with salicylate allergy.

Pylera capsules (bismuth subcitrate potassium 140 mg, metronidazole 125 mg, tetracycline 125 mg)

3 capsules four times daily after meals and at bedtime + omeprazole 20 mg twice daily

Label: 10 days, with omeprazole after the morning and evening meals. ACG prefers 14 days of optimized BQT and PPIs 30–60 minutes before meals; Pylera is dispensed as a 10-day course, so 14 days needs extra capsules. Pylera supplies tetracycline 375 mg four times daily, below ACG’s 500 mg.

  • ACG 2024: optimized BQT is recommended first line (strong, moderate evidence) and is the only first-line option suitable for true penicillin allergy.

Before prescribing

Confirm active infection and prior regimens. Contraindicated in pregnancy, severe renal impairment, Cockayne syndrome, disulfiram within 2 weeks; not for Child-Pugh C. Review warfarin, lithium, busulfan, phenytoin, QT drugs and hormonal contraception.

Side effects and return precautions

Black tongue/stool (benign) vs melena; GI upset, metallic taste, alcohol reaction, photosensitivity, C. difficile, SJS/TEN/DRESS, neuropathy, encephalopathy, intracranial hypertension.

Follow-up

Test of cure (urea breath, stool antigen or biopsy) ≥4 weeks after therapy, off PPI 2 weeks and bismuth/antibiotics 4 weeks. Persistent infection after BQT: rifabutin triple therapy or susceptibility-guided salvage.

Sources

Checked October 15, 2026.

Budesonide/formoterol (Symbicort, Breyna)Asthma maintenance

What to say

For your asthma, use two puffs of the prescribed budesonide/formoterol strength twice daily, morning and evening. The steroid reduces inflammation and the long-acting medicine opens the airways. In this plan it’s your daily maintenance inhaler. Use your separate rescue medicine for sudden symptoms and don’t take extra doses of this inhaler.

Let’s practice using the inhaler. Rinse your mouth and spit after each dose. Hoarseness, white patches in the mouth or shakiness can happen. Call if rescue use increases or relief doesn’t last. Stop this inhaler and follow your urgent plan if a puff immediately worsens breathing. Severe breathlessness or difficulty speaking means call 911.

Clinical reference

Dose options

U.S.-labeled asthma maintenance

80/4.5 or 160/4.5 mcg: 2 puffs twice daily

Maximum labeled maintenance: 160/4.5, 2 puffs BID. Separate rescue medicine under this plan.

Before prescribing

Confirm exact strength, technique, adherence and separate rescue plan; avoid duplicate LABA. Review drug interactions and whether ICS/LABA is appropriate for this patient.

Side effects and return precautions

Thrush, hoarseness, tremor and palpitations; paradoxical bronchospasm requires prompt treatment. Increasing rescue need or night symptoms warrants reassessment.

Follow-up

Review technique, refill access, symptoms and rescue use within 1–3 months after a stable treatment change; sooner after an exacerbation. Do not add SMART rescue dosing to this plan.

Sources

Checked September 22, 2026.

Budesonide/formoterol (Symbicort, Breyna)Asthma, maintenance and reliever (SMART)

What to say

For the asthma plan we’ve chosen, this inhaler provides both the regular treatment and extra symptom relief. Your scheduled dose is [strength, number of puffs, and times each day]. When symptoms occur, use [rescue puffs and repeat instructions]. The total limit is [maximum puffs in a day], counting the scheduled and extra doses together.

The steroid reduces inflammation and formoterol opens the airways. Let’s check your technique, and rinse your mouth and spit after using it. Hoarseness, thrush (white patches or soreness in the mouth) or shakiness can happen. Call the same day if relief isn’t lasting or you’re needing more than the plan allows, before exceeding the daily limit. Severe breathlessness or inability to speak normally means call 911. I’ll prescribe for this use. Tell us early if the pharmacy or insurance won’t supply enough.

Clinical reference

Dose options

Clinician-directed asthma SMART/MART

Maintenance 1–2 puffs once or twice daily plus 1–2 puffs as needed, depending on strength and severity

For adults using 4.5 mcg formoterol/puff: maximum 12 total puffs/day including maintenance. This guideline-supported approach differs from U.S. maintenance labeling; specify a complete plan.

Before prescribing

Choose one clear maintenance/rescue strategy and exact product; no duplicate LABA. Review technique, adherence, exacerbations and refill quantity. Do not substitute another ICS/LABA combination into a SMART plan.

Side effects and return precautions

Thrush/hoarseness, tremor/palpitations; rinse/spit. Paradoxical bronchospasm or severe persistent breathing symptoms needs urgent action. Clarify when to call before the daily ceiling is exceeded.

Follow-up

Review technique, symptoms, rescue counts and access. Stable treatment-change review often within 1–3 months; post-exacerbation sooner. Document actual written maximum, not just an acronym.

Sources

Checked September 22, 2026.

Budesonide/formoterol (Symbicort, Breyna)COPD maintenance

What to say

For your COPD, use budesonide/formoterol 160/4.5, two puffs twice daily. Use it every day to help control symptoms and reduce flare-ups. It isn’t your rescue treatment. Keep the separate rescue medicine in your written plan available for sudden symptoms.

Let’s practice using the inhaler. Rinse your mouth and spit after each dose. Hoarseness, white patches in the mouth or shakiness can happen. Call if rescue use increases or relief doesn’t last. Stop this inhaler and follow your urgent plan if a puff immediately worsens breathing. Severe breathlessness or difficulty speaking means call 911.

Clinical reference

Dose options

U.S.-labeled COPD maintenance

160/4.5 mcg: 2 puffs twice daily

Do not extrapolate asthma SMART instructions to COPD.

Before prescribing

Confirm exact strength, technique, adherence and separate rescue plan; avoid duplicate LABA. Review drug interactions and whether ICS/LABA is appropriate for this patient.

Side effects and return precautions

Thrush, hoarseness, tremor and palpitations; paradoxical bronchospasm requires prompt treatment. Review pneumonia risk and seek assessment for fever, changed sputum or worsening breathlessness.

Follow-up

Review technique, refill access, symptoms and rescue use within 1–3 months after a stable treatment change; sooner after an exacerbation. Do not add SMART rescue dosing to this plan.

Sources

Checked September 22, 2026.

Buprenorphine/naloxone (Suboxone, Zubsolv)Opioid use disorder

What to say

This medicine eases opioid withdrawal and cravings. Take the first dose only when you’re clearly in withdrawal, with signs like yawning, runny nose, goosebumps, sweating or cramps; starting too early can cause sudden, worse withdrawal. Let a 4-milligram film dissolve completely under your tongue, without eating or drinking. If withdrawal continues after about 2 hours, take another. Many people need 8 to 16 milligrams on day one, then one daily dose as written on your plan.

Constipation, headache and nausea are common. Alcohol, benzodiazepines, sleep medicines or other opioids can slow breathing dangerously; tell us about them so we can plan safely, not to stop your care. Keep naloxone at home, and call 911 if someone is hard to wake or breathing slowly. Lock it away; it can kill a child. After it dissolves, swish water over your teeth, swallow, and wait an hour to brush. Don’t stop suddenly.

Clinical reference

Dose options

Standard (home) initiation, Suboxone film

At COWS ≥8 with ≥1 objective sign: 2–4 mg, repeat 2–4 mg about every 2 h as needed; label day 1 up to 8 mg, day 2 up to 16 mg

ASAM guidance for high-potency synthetic opioids supports faster, higher day-1 dosing (often ≥16 mg) with high tolerance; the script follows it. Label: first dose not less than 6 h after a short-acting opioid.

Maintenance

Target about 16 mg/4 mg daily; usual range 4–24 mg/day

Label: >24 mg/day not studied in RCTs but may be appropriate for some patients; ASAM notes ≥16 mg is often needed with fentanyl exposure. Zubsolv 5.7 mg/1.4 mg ≈ Suboxone 8 mg/2 mg; don’t convert mg-for-mg.

COWS <8 or high precipitated-withdrawal risk

Low-dose initiation with opioid continuation, or high-dose initiation, per ASAM

Regimens outside the label; use a written protocol. Long-acting injectable buprenorphine (Sublocade, Brixadi) is an option once established.

Before prescribing

Confirm OUD, opioid type and last use, pregnancy, severe liver disease (avoid the combination) and sedative or alcohol use. Check CURES before the first prescription and every 6 months. No X-waiver needed (DEA Schedule III registration). Prescribe naloxone.

Side effects and return precautions

Precipitated withdrawal; sedation or respiratory depression with CNS depressants; constipation, hepatitis, dental decay, orthostasis. Don’t categorically withhold treatment for benzodiazepine use; counsel and plan. Pediatric exposure can be fatal.

Follow-up

Contact within days of starting, then frequently while adjusting; toxicology testing as part of care. Treatment may continue for years; plan any taper gradually with the patient, never abruptly.

Sources

Checked October 15, 2026.

Bupropion SR (Zyban)Smoking cessation

What to say

Bupropion can reduce nicotine cravings and withdrawal. Start one 150-milligram SR tablet each morning for three days, then one tablet twice a day, at least eight hours apart, if tolerated. Set your quit date about one to two weeks after starting. Swallow tablets whole and avoid taking the second dose near bedtime.

Dry mouth or difficulty sleeping can happen. Skip a missed dose rather than taking extra, and don’t combine this with another bupropion product. Tell us about seizures, eating disorders or regular heavy alcohol or sedative use before starting. Stop and call for major mood or behavior changes. A seizure or immediate danger of self-harm means call 911. We’ll pair the medicine with quit-smoking support.

Clinical reference

Dose options

Adult smoking cessation

150 mg daily for 3 days, then 150 mg twice daily at least 8 hours apart; maximum 300 mg/day

Typical treatment is 7–12 weeks; review progress and need for continuation. Renal or hepatic impairment can require a lower dose/frequency.

Before prescribing

Review BP, bipolar disorder, pregnancy, renal/hepatic function and interactions. Contraindicated with seizure disorder, current/prior anorexia or bulimia, abrupt alcohol/sedative/antiepileptic withdrawal, concurrent bupropion or recent MAOI use. Do not abruptly stop dependent alcohol or sedative use.

Side effects and return precautions

Insomnia, dry mouth, hypertension, seizure and neuropsychiatric changes. Monitor BP particularly if also using a nicotine patch.

Follow-up

Check in around the quit date and during the first month. If not abstinent after 7–12 weeks, reassess the strategy rather than continuing indefinitely without benefit.

Sources

Checked September 23, 2026.

Bupropion XL (Wellbutrin XL)Depression

What to say

We’ll start the once-daily XL form of bupropion at 150 milligrams each morning. Swallow it whole. It can be helpful for depression, but the benefit still takes several weeks.

It can cause dry mouth, constipation, anxiety or trouble sleeping. Tell me if you feel unusually wound up, and we’ll check blood pressure because it can rise. If you miss a dose, skip it. Taking extra or doses too close together increases seizure risk. We’ll decide together whether to increase to 300 milligrams after checking how you’re doing on 150 milligrams. I need to know about any seizure history, current or past anorexia or bulimia, and alcohol or sedative use. Don’t abruptly stop heavy drinking or regular sedatives without medical help. New suicidal thoughts or major mood changes need a same-day call. A seizure or immediate danger of self-harm means call 911.

Clinical reference

Dose options

XL start

150 mg orally each morning

Swallow whole; doses at least 24 hours apart.

Usual target

300 mg each morning; label permits increase after four days

Increase according to tolerance and clinical plan, not automatically in every patient.

Higher dose / impairment

450 mg/day is the ceiling discussed in the cited label; review product and seizure risk before going above 300 mg

Consider dose/frequency reduction with GFR <90. Child-Pugh 7–15: maximum 150 mg every other day; milder liver disease may also need reduction.

Before prescribing

Contraindicated with seizure disorder, current/prior bulimia or anorexia, and abrupt alcohol/sedative withdrawal. Check duplicate bupropion products, MAOIs, bipolarity, interacting drugs and baseline BP.

Side effects and return precautions

Insomnia, activation, dry mouth and constipation; dose-related seizure risk, hypertension, suicidality/mania. A seizure or inability to remain safe needs emergency help; limit/avoid alcohol with an individualized withdrawal assessment.

Follow-up

Early mood/safety review within one to two weeks according to risk, periodic BP and reassessment of benefit over weeks. Never double a missed dose; plan refills and stopping.

Sources

Checked September 20, 2026.

Bupropion XL (Wellbutrin XL)Seasonal affective disorder prevention

What to say

Because your depression tends to return in the fall or winter, we’re starting bupropion XL before your usual symptoms begin. Take 150 milligrams each morning for seven days, then 300 milligrams each morning if tolerated and that remains our plan. Swallow it whole. This is seasonal prevention. Tell us promptly if depression is already developing.

It can cause trouble sleeping, dry mouth or anxiety, and we’ll check blood pressure. Skip a missed dose rather than doubling. We need to review any seizure or eating-disorder history and alcohol or sedative use first. Contact us promptly for major mood changes or self-harm thoughts. Call 911 for a seizure or immediate danger. In early spring, we’ll plan when to reduce 300 milligrams to 150 milligrams before stopping.

Clinical reference

Dose options

Seasonal prevention with XL

150 mg each morning for 7 days, then 300 mg each morning if tolerated

Begin in autumn before symptoms, continue through winter, and taper in early spring. Doses above 300 mg/day were not evaluated for seasonal prevention.

Stopping and organ function

Reduce 300 mg to 150 mg daily before stopping; individualize timing

Reduce dose/frequency with renal or hepatic impairment; moderate/severe hepatic impairment maximum 150 mg every other day.

Before prescribing

Contraindicated with seizure disorder, current/prior bulimia or anorexia, and abrupt alcohol/sedative withdrawal. Check duplicate bupropion products, MAOIs, bipolarity, interacting drugs and baseline BP.

Side effects and return precautions

Insomnia, activation, dry mouth and constipation; dose-related seizure risk, hypertension, suicidality/mania. A seizure or inability to remain safe needs emergency help; limit/avoid alcohol with an individualized withdrawal assessment.

Follow-up

Review mood, sleep, activation and BP in 1–2 weeks and through the season. Agree on the spring taper and reassess the seasonal pattern annually.

Sources

Checked September 23, 2026.

Buspirone (BuSpar)Generalized anxiety

What to say

Buspirone is a scheduled treatment for anxiety. Start 7.5 milligrams twice a day. Take it consistently either with food or without food. It works gradually over several weeks, so take it regularly rather than only during an anxious moment.

Dizziness, nausea or headache can happen, especially early. See how it affects you before driving. We’ll check how you’re doing in two to four weeks and adjust the dose if needed. Ask the pharmacist what amount of grapefruit is safe with your prescription, and check before adding other mood medicines or supplements. Fever with agitation, confusion, shaking or stiff muscles means go to the emergency department. If you’re also taking a benzodiazepine such as [your medicine] regularly, don’t stop that suddenly. Buspirone doesn’t prevent its withdrawal.

Clinical reference

Dose options

Starting dose

7.5 mg orally twice daily

Some clinicians use 5 mg two or three times daily for tolerability.

Titration / usual range

Increase total daily dose by 5 mg every 2–3 days if needed and tolerated; often 20–30 mg/day in divided doses

Maximum 60 mg/day; practical outpatient titration may be slower.

Renal/hepatic impairment

Use is not recommended in severe renal or hepatic impairment

Exposure increases; lower/slower dosing may be needed in less severe impairment. Strong CYP3A4 interactions require specific dosing.

Before prescribing

Review diagnosis, suicidality, MAOI use, serotonergic drugs, CYP3A4 interactions, kidney/liver disease and benzodiazepine dependence. Contraindicated with specified MAOI combinations including relevant linezolid/IV methylene blue use.

Side effects and return precautions

Dizziness, nausea, headache and restlessness; serotonin syndrome with interacting drugs. New self-harm thoughts need same-day contact; immediate danger means 911.

Follow-up

Review tolerability, anxiety and function in 2–4 weeks, earlier if problems. Check consistent administration/adherence before escalating.

Sources

Checked September 20, 2026.

Cabotegravir (Apretude)HIV prevention (PrEP)

What to say

Apretude helps prevent HIV from sex without taking a daily pill. We’ll give a 600-milligram injection into the buttock today, another in one month, then one every two months. HIV testing is needed before each injection.

Soreness or a lump at the injection site is common. Call for a significant rash, yellow skin or eyes, or worsening mood. Tell us promptly about flu-like symptoms after an exposure. Contact us before missing an appointment or stopping: the medicine stays in your body for a long time, but protection eventually falls and you may need another PrEP medicine. It doesn’t prevent other STIs or replace emergency PEP.

Clinical reference

Dose options

PrEP, weight ≥35 kg

600 mg (3 mL) gluteal IM initially, at 1 month, then every 2 months

Optional oral cabotegravir lead-in: 30 mg daily for at least 28 days; not required. Usual injection window is ±7 days.

Before prescribing

Confirm HIV-negative status with Ag/Ab and HIV-1 RNA testing; assess acute infection and recent PEP need. Review liver disease, mood and drug interactions. Plan HBV care if stopping tenofovir.

Side effects and return precautions

Injection reactions; uncommon serious hypersensitivity, liver injury and depressive symptoms. Low residual drug levels after stopping can allow resistant HIV.

Follow-up

HIV testing at each injection, STI screening by risk. If stopping with ongoing exposure risk, provide oral PrEP within 8 weeks after the last shot; HIV Ag/Ab and RNA every 3 months for 12 months. Use the label for missed-dose bridging/restart.

Sources

Checked September 23, 2026.

Calcium and vitamin D supplementsBone health

What to say

Food comes first. Adults need about 1,000–1,200 milligrams of calcium a day from food and supplements together, so we only fill the gap. Take no more than about 500 milligrams at a time. Calcium carbonate works best with a meal. Calcium citrate can be taken any time. For vitamin D, 800–1,000 units a day is typical after age 50, and 4,000 units is the upper limit. If you don’t have osteoporosis or low vitamin D, these supplements haven’t been shown to prevent fractures.

Constipation and gas are common; smaller doses or citrate can help. Too much calcium can cause kidney stones, so call us for severe side or back pain or blood in your urine. Take levothyroxine at least 4 hours apart from calcium. Take alendronate first, then wait 30 minutes before calcium. Ask us before combining with antibiotics like ciprofloxacin.

Clinical reference

Dose options

Calcium: total daily intake (diet plus supplement)

Men 50–70: 1,000 mg/day; women 51 and older and men 71 and older: 1,200 mg/day; supplement only the shortfall, in doses of about 500 mg or less

Upper limit 2,000 mg/day at age 51 and older (2,500 mg at 19–50). Carbonate (40% elemental) with meals; citrate (21% elemental) any time, useful with PPIs, achlorhydria or IBD. Supplemental calcium above 1,200–1,500 mg/day can add kidney-stone risk in at-risk people.

Vitamin D (cholecalciferol)

800–1,000 IU/day for adults 50 and older (BHOF); RDA 600 IU to age 70 and 800 IU from 71; upper limit 4,000 IU/day

BHOF prefers 25(OH)D of at least 30 ng/mL in metabolic bone disease (20 ng/mL may suffice in healthy adults). Higher doses may be needed with malabsorption; treat deficiency with its own regimen.

Spacing from other drugs

Levothyroxine at least 4 hours apart; alendronate with plain water at least 30 minutes before any food, drink or supplement

NIH ODS also flags dolutegravir, lithium and quinolone antibiotics; check each label’s spacing instructions.

  • USPSTF 2018 advises against 400 IU or less of vitamin D3 plus 1,000 mg or less of calcium for fracture prevention in community-dwelling postmenopausal women; it excludes osteoporosis, vitamin D deficiency and prior fracture. A December 2024 draft update (vitamin D with or without calcium, women and men 60 and older) is not final.

Before prescribing

Estimate dietary calcium first. Review hypercalcemia, hyperparathyroidism, CKD, kidney stones, PPI use, levothyroxine, bisphosphonates, quinolones, dolutegravir, lithium and osteoporosis therapy. Check 25(OH)D when deficiency or malabsorption is suspected.

Side effects and return precautions

Constipation, bloating and kidney stones; hypercalcemia (thirst, confusion, nausea, severe constipation) with excess calcium plus vitamin D. NIH ODS notes mixed data on cardiovascular risk with calcium supplements.

Follow-up

Recheck dietary intake and need at osteoporosis visits. Recheck calcium and 25(OH)D with CKD, malabsorption, deficiency or high-dose vitamin D. Stop supplements that are not closing an intake gap.

Sources

Checked October 15, 2026.

Carbamide peroxide ear drops (Debrox)Earwax

What to say

Carbamide peroxide drops, such as Debrox, soften earwax so it can come out. Tilt your head and place 5–10 drops in the ear, keeping the tip out of your ear canal. Stay tilted for several minutes, or put cotton in the ear. Use them twice a day for up to 4 days. Fizzing or crackling is normal. If wax remains, gently flush the ear with warm water using a soft rubber bulb syringe.

Ask us first if you have ear pain, drainage, dizziness, a hole in the eardrum, ear tubes or recent ear surgery. Don’t use cotton swabs, hairpins or ear candles; they can push wax deeper or injure the ear. Stop and call us if you need the drops for more than 4 days or wax still blocks your hearing. Call the same day for severe ear pain, drainage or dizziness.

Clinical reference

Dose options

Earwax softening (carbamide peroxide 6.5%)

Adults and children over 12: 5–10 drops in the affected ear twice daily for up to 4 days; keep the head tilted for several minutes

Children under 12: consult a doctor. Applicator tip must not enter the canal. Remaining wax may be flushed with warm water using a soft rubber bulb syringe. The product foams on contact with wax.

When not to use without a clinician

Ear drainage, pain, rash or irritation, dizziness, eardrum injury or perforation, or recent ear surgery

Treat ear tubes like a perforation (conservative; not stated on the Drug Facts label). Needing more than 4 days or persistent wax calls for in-office removal.

  • AAO-HNSF guideline: treat symptomatic impaction with a cerumenolytic, irrigation or manual removal (no method is superior); wax that causes no symptoms needs no routine removal.

Before prescribing

Examine for a perforated tympanic membrane, tubes, otitis, exostoses or canal narrowing before softening or irrigation. Ask about diabetes, immune compromise, anticoagulants and hearing aids. Do not treat asymptomatic wax routinely.

Side effects and return precautions

Mild irritation or transient hearing change after drops. Pain, drainage, dizziness, new hearing loss or tinnitus warrant otoscopy to exclude infection, perforation or another cause.

Follow-up

Recheck hearing and the canal if symptoms persist after 4 days. Arrange in-office removal if the wax is not cleared, and explain safe ear hygiene (no swabs or candling).

Sources

Checked October 15, 2026.

Carvedilol (Coreg)Heart failure

What to say

I’m starting carvedilol 3.125 milligrams twice a day for your stable heart failure. Take it with breakfast and your evening meal. We begin low and increase gradually as your body adjusts. Over time it helps protect your heart. Keep taking it even if you don’t feel an immediate benefit.

You may feel tired or lightheaded at first. Get up slowly and check your blood pressure, pulse, and daily weight as we discussed. Call the same day for new swelling, worsening breathlessness, or dizziness with a slow pulse. Severe trouble breathing, fainting, or chest pain means call 911. Don’t stop it suddenly or increase it yourself. We’ll review you in two weeks before deciding on the next dose. If you miss a dose, take it unless the next is close. Don’t take two together.

Clinical reference

Dose options

Stable HFrEF start / titration

3.125 mg orally twice daily with food for 2 weeks

If tolerated, increase to 6.25, 12.5, then 25 mg twice daily at intervals ≥2 weeks. Stabilize fluid retention first.

HFrEF upper dosing

Usually 25 mg twice daily; selected patients >85 kg may receive 50 mg twice daily

The higher dose is described for mild/moderate HF; not a default target for all patients.

Before prescribing

Check BP/pulse, volume status, conduction disease and interacting rate-slowing medicines. Contraindications include asthma/bronchospasm, significant unpaced heart block or severe bradycardia, shock and decompensated HF requiring IV inotropes. Review diabetes and masked hypoglycemia. Severe hepatic impairment is contraindicated.

Side effects and return precautions

Fatigue, dizziness and bradycardia are common concerns; worsening fluid retention needs review before titration. Define individualized pulse/BP call thresholds. Withdrawal can worsen ischemia; planned discontinuation generally tapers over 1–2 weeks.

Follow-up

Assess symptoms, weight, BP/pulse and tolerance at each ≥2-week HF titration step. Monitor renal function if hypotension or renal risk; avoid treating acute decompensation with an outpatient dose increase.

Sources

Checked September 22, 2026.

Carvedilol (Coreg)Hypertension

What to say

For your blood pressure, start immediate-release carvedilol 6.25 milligrams twice daily with breakfast and your evening meal. Keep a home blood-pressure and pulse record. We’ll review in one to two weeks before adjusting it. This is the twice-daily tablet, not the extended-release capsule.

You may feel tired or lightheaded at first. Get up slowly and check your blood pressure and pulse as we discussed. Call the same day for new swelling, worsening breathlessness, or dizziness with a slow pulse. Severe trouble breathing, fainting, or chest pain means call 911. Don’t stop it suddenly or increase it yourself. If you miss a dose, take it unless the next is close. Don’t take two together.

Clinical reference

Dose options

Hypertension

6.25 mg twice daily; increase to 12.5 then 25 mg twice daily if needed

Allow 1–2 weeks between increases; maximum 50 mg/day. Take with food. Severe hepatic impairment is contraindicated.

Before prescribing

Check BP/pulse, volume status, conduction disease and interacting rate-slowing medicines. Contraindications include asthma/bronchospasm, significant unpaced heart block or severe bradycardia, shock and decompensated HF requiring IV inotropes. Review diabetes and masked hypoglycemia.

Side effects and return precautions

Fatigue, dizziness and bradycardia are common concerns; worsening fluid retention needs review before titration. Define individualized pulse/BP call thresholds. Withdrawal can worsen ischemia; planned discontinuation generally tapers over 1–2 weeks.

Follow-up

Review BP, standing symptoms and pulse at 1–2 weeks before each increase. Use individualized call thresholds. Taper planned discontinuation over 1–2 weeks rather than abrupt withdrawal.

Sources

Checked September 22, 2026.

Carvedilol (Coreg)Reduced heart function after a heart attack

What to say

Your heart’s pumping strength was reduced after the heart attack. Carvedilol is part of the plan to protect your heart and improve survival. Continue the immediate-release dose on your discharge list twice daily with meals. We may increase it gradually after checking your pulse, blood pressure and symptoms. Don’t stop it suddenly.

Tiredness or lightheadedness can happen. Get up slowly and keep the home pulse, blood-pressure and weight record we discussed. Call the same day for increasing swelling, breathlessness or dizziness with a slow pulse. New chest pain, fainting or severe trouble breathing means call 911. We’ll confirm your next review and who will adjust the dose.

Clinical reference

Dose options

Stable adult after MI with LVEF ≤40%

Start 6.25 mg twice daily with food; increase to 12.5 then 25 mg twice daily, at intervals of 3–10 days if tolerated

Begin only after hemodynamic stability and control of fluid retention. Continue the established discharge dose rather than restarting this sequence.

Lower-dose pathway

May start 3.125 mg twice daily and/or titrate more slowly

Use for low BP/pulse or other tolerability concerns. This indication’s schedule differs from the usual ≥2-week HFrEF titration.

Before prescribing

Verify infarct history, LVEF and discharge plan. Check BP, pulse, volume status, conduction disease, bronchospasm, severe hepatic impairment and interacting rate-slowing drugs. Do not initiate in shock or decompensation needing IV inotropes.

Side effects and return precautions

Bradycardia, hypotension and worsening fluid retention need reassessment before titration. Review masked hypoglycemia in diabetes. Abrupt withdrawal may provoke ischemia.

Follow-up

Reassess before each planned increase; agree individualized call thresholds. Coordinate cardiology follow-up and monitor renal function if hypotension or renal risk develops.

Sources

Checked September 23, 2026.

Ceftriaxone (Rocephin)Gonorrhea

What to say

We’ll treat gonorrhea with one ceftriaxone injection. The dose depends on your weight. If you also have chlamydia, or we haven’t ruled it out, you may need a separate antibiotic. We’ll choose that based on your results and whether pregnancy is possible.

Avoid sex for seven days after treatment and until your partners have been treated and symptoms have resolved. We can help arrange partner care. We’ll retest in three months. If the infection is in your throat, you also need a clearance test in 7–14 days. The injection can be sore. Get urgent care for fever with pelvic, testicular or joint pain, and call 911 for breathing trouble or swelling after the shot.

Clinical reference

Dose options

Uncomplicated genital, rectal or pharyngeal gonorrhea

Under 150 kg: 500 mg IM once; ≥150 kg: 1 g IM once

CDC regimen. Chlamydia coinfection needs separate treatment; use the pregnancy-appropriate regimen when applicable.

Before prescribing

Document infection sites, weight, pregnancy and cephalosporin/beta-lactam reaction details. Test for other STIs and offer PrEP when appropriate. Complicated or disseminated disease needs a different plan.

Side effects and return precautions

Injection pain, diarrhea and allergy. Persistent symptoms require culture and susceptibility assessment, not automatic repeat treatment.

Follow-up

Arrange partner evaluation/treatment for the previous 60 days. Retest at 3 months. Throat test of cure at 7–14 days; day 7 NAAT can be falsely positive. Routine cure testing is unnecessary for appropriately treated uncomplicated genital/rectal infection.

Sources

Checked September 23, 2026.

Ceftriaxone (Rocephin) with doxycyclineEpididymitis

What to say

This treats epididymitis, an infection of the coiled tube behind the testicle, most likely from chlamydia or gonorrhea. You’ll get one ceftriaxone shot today. Then take doxycycline 100 milligrams twice a day for 10 days with a full glass of water. Don’t take it with antacids, iron or calcium, and use sun protection. Rest, support or raise the scrotum, and use an anti-inflammatory such as ibuprofen if it’s safe for you.

Avoid sex until you and your partners from the past 60 days are treated and your symptoms are gone. We’ll also test for HIV and syphilis. You should be improving within three days; if not, call us. Soreness can take a few weeks to fully settle. Sudden severe testicle pain means go to the emergency department now. Call the same day for high fever, vomiting or worsening swelling. Trouble breathing or face swelling after the shot means call 911.

Clinical reference

Dose options

Likely chlamydia or gonorrhea

Ceftriaxone 500 mg IM once (1 g if ≥150 kg) plus doxycycline 100 mg orally twice daily for 10 days

CDC 2021 regimen, started presumptively at the visit. The ceftriaxone label still lists 250 mg for uncomplicated gonorrhea; the doxycycline label lists ≥10 days for gonococcal or chlamydial epididymo-orchitis.

Insertive anal sex (STI plus enteric organisms possible)

Ceftriaxone 500 mg IM once plus levofloxacin 500 mg orally once daily for 10 days

Levofloxacin replaces doxycycline in this scenario.

Enteric organisms only

Levofloxacin 500 mg orally once daily for 10 days

Use when gonorrhea is ruled out (e.g., by Gram stain); guide by urine culture and susceptibility.

Before prescribing

Sudden severe pain or atypical findings: urgent urology and ultrasound to exclude torsion. Confirm inflammation (urethral stain, leukocyte esterase or ≥10 WBC/HPF on first-void urine); urine NAAT for gonorrhea and chlamydia plus urine culture; HIV and syphilis tests. Check weight and cephalosporin allergy.

Side effects and return precautions

Torsion, abscess or infarction if not improving; persistent swelling after treatment warrants evaluation for tumor, TB or fungal infection. Doxycycline esophagitis and photosensitivity; ceftriaxone hypersensitivity; C. difficile.

Follow-up

Reassess if no improvement within 72 hours. Partners from the prior 60 days need evaluation and treatment (consider expedited partner therapy). Complete resolution of discomfort may take a few weeks.

Sources

Checked October 15, 2026.

Ceftriaxone, doxycycline and metronidazolePelvic inflammatory disease

What to say

Pelvic inflammatory disease is an infection of the uterus, tubes or ovaries; prompt treatment helps protect fertility. You’ll get one ceftriaxone shot today. Then take doxycycline 100 milligrams and metronidazole 500 milligrams, each twice a day for 14 days. Take doxycycline with a full glass of water, and use sun protection. Avoid alcohol until three days after your last metronidazole dose. If you have an IUD, it can usually stay in.

We’ll check in within three days. Avoid sex until you finish treatment, your symptoms are gone and your partners from the past 60 days are treated. If tests show chlamydia or gonorrhea, we’ll retest in three months. Call the same day if you aren’t improving, are vomiting, can’t keep pills down, or have a fever over 101 degrees. Go to the emergency department for severe belly pain, fainting, or pain with a positive pregnancy test. Trouble breathing or facial swelling after the shot means call 911.

Clinical reference

Dose options

Mild to moderate PID, IM and oral

Ceftriaxone 500 mg IM once plus doxycycline 100 mg orally twice daily for 14 days plus metronidazole 500 mg orally twice daily for 14 days

CDC 2021. Ceftriaxone 1 g if >150 kg with documented gonorrhea. Alternative: cefoxitin 2 g IM with probenecid 1 g orally once, plus the same oral drugs.

Metronidazole and alcohol

Label: avoid alcohol and propylene glycol during treatment and for at least 3 days afterward

The script follows the label; the CDC PID guidance doesn’t address alcohol. Don’t give within 2 weeks of disulfiram.

Hospitalize instead

Pregnancy, tubo-ovarian abscess, possible surgical emergency, severe illness, vomiting or temperature >38.5°C, inability to follow or tolerate oral therapy, or no response by 72 hours

CDC hospitalization criteria; use a parenteral regimen.

Before prescribing

Minimum criteria: cervical motion, uterine or adnexal tenderness without another cause. Pregnancy test; NAAT for gonorrhea and chlamydia; HIV and syphilis tests. Check cephalosporin allergy, weight, disulfiram within 2 weeks, warfarin, lithium and QT-prolonging drugs.

Side effects and return precautions

No improvement within 72 hours, tubo-ovarian abscess, peritonitis or ectopic pregnancy needs urgent reassessment. Doxycycline esophagitis and photosensitivity; metronidazole nausea, metallic taste, neuropathy, seizures and alcohol reaction.

Follow-up

Review within 72 hours; consider IUD removal if no improvement in 48–72 hours. Treat partners from the 60 days before symptoms for gonorrhea and chlamydia. Retest 3 months after treatment for gonorrhea or chlamydia, or at the next visit within 12 months.

Sources

Checked October 15, 2026.

Celecoxib (Celebrex)Osteoarthritis pain

What to say

For your osteoarthritis pain, take celecoxib 200 milligrams once a day, or 100 milligrams twice a day, with or without food. We’ll use the lowest dose that helps, for the shortest time needed. Don’t take it with ibuprofen, naproxen or other anti-inflammatory pain medicines. Don’t take it if sulfa drugs caused an allergic reaction, or aspirin or similar medicines caused asthma or hives.

Indigestion and ankle swelling can happen, and blood pressure can rise. Stomach bleeding can occur without warning. Stop it and go to the emergency department for black or bloody stools or vomiting blood. Stop it and call 911 for chest pain, sudden breathlessness, face drooping, arm weakness, trouble speaking, or swelling of the face or throat. Stop it and call us the same day for a rash, yellow skin, much less urine or new leg swelling. Tell us if you take a blood thinner, aspirin or lithium, or could be pregnant. We’ll review it on [date].

Clinical reference

Dose options

Osteoarthritis

200 mg orally once daily, or 100 mg twice daily

Labeled OA dose is 200 mg/day; use the lowest effective dose for the shortest duration, without regard to meals. In PRECISION, 100 mg twice daily was CV-noninferior to ibuprofen and naproxen.

Hepatic impairment / CYP2C9

Child-Pugh B: reduce the daily dose by 50%; Child-Pugh C: not recommended; known or suspected CYP2C9 poor metabolizers: start at half the lowest dose

CYP2C9 inhibitors (e.g., fluconazole) raise exposure. Not recommended in severe renal insufficiency.

GI protection

Consider a PPI when GI risk factors are present

Risk rises with age, prior ulcer or bleeding, anticoagulants, antiplatelets, SSRIs/SNRIs or corticosteroids. All PRECISION participants received esomeprazole.

  • ACR 2026 update: oral NSAIDs strongly recommended for knee, hip and hand OA; topical NSAIDs conditionally preferred over oral for knee and hand OA.

Before prescribing

Contraindicated: sulfonamide allergic-type reaction, aspirin/NSAID-induced asthma or urticaria, CABG setting. Review CV disease or recent MI, HF, BP, eGFR, ulcer/GI bleeding, anticoagulants, SSRIs, lithium, ACEi/ARB/diuretics, liver disease and pregnancy (avoid ≥30 weeks; limit from 20 weeks).

Side effects and return precautions

Dyspepsia, diarrhea, edema, hypertension. Boxed CV thrombotic and GI bleeding risks; AKI and hyperkalemia, hepatotoxicity, anaphylaxis, SJS/TEN/DRESS. Not a substitute for low-dose aspirin cardioprotection.

Follow-up

Review function, pain, BP, edema and GI symptoms within 2–4 weeks; stop without meaningful benefit. With ongoing use, periodically check CBC and chemistry, including renal and liver tests.

Sources

Checked October 15, 2026.

Cephalexin (Keflex)Cellulitis

What to say

For this skin infection, take cephalexin 500 milligrams four times a day for five days. We’ll write down a schedule you can follow. Food is optional, but it can help if your stomach feels upset.

We should see the redness and tenderness start improving over the next two to three days. Call the same day if redness is spreading, pain is increasing, fever develops, or you aren’t improving. Nausea or loose stools can happen. Stop and call the same day for a new rash. Trouble breathing or tongue swelling means stop and call 911. Severe watery or bloody diarrhea needs a same-day call, even if it starts after the course ends.

Clinical reference

Dose options

Uncomplicated nonpurulent cellulitis

500 mg orally four times daily; initial course often 5 days

Guideline regimen; extend only if insufficient improvement. Purulence, abscess or MRSA risk can change treatment.

Other labeled adult schedules

250 mg every 6 hours or 500 mg every 12 hours; severe infection up to 4 g/day divided

Dose/duration depend on infection; do not substitute a lower-frequency schedule for the cellulitis regimen above.

Renal adjustment

CrCl 30–59: maximum 1 g/day; 15–29: 250 mg every 8–12 hours

More severe impairment requires a longer interval per label. Review renal function before using 500 mg four times daily.

Before prescribing

Confirm site/severity, abscess/drainage need, allergy reaction details and renal function. Consider MRSA coverage only when indicated. Rapid progression/systemic toxicity changes care setting.

Side effects and return precautions

GI upset, diarrhea and rash; severe allergy or blistering/mucosal rash requires stopping and emergency assessment. Severe diarrhea may be C. difficile.

Follow-up

Reassess in 48–72 hours if not clearly improving, sooner if worse; use extent of erythema and symptoms to judge response. Do not automatically prolong a responding course.

Sources

Checked September 20, 2026.

Cephalexin (Keflex)Strep throat with a low-risk penicillin allergy

What to say

After reviewing your penicillin reaction, we’ve chosen cephalexin for your confirmed strep throat. Take 500 milligrams twice a day for ten days. You can take it with food if your stomach is upset. Finish the prescribed course even if your throat feels better.

This choice depends on the kind of allergy you had. Tell us before starting if penicillin caused hives, swelling, breathing trouble, blistering skin, mouth sores or organ problems. Stop and call for a new rash. Trouble breathing or tongue swelling means call 911. Call for severe or bloody diarrhea. Stay home until you’re fever-free and have taken antibiotics for at least 24 hours.

Clinical reference

Dose options

Adult strep throat

500 mg orally twice daily for 10 days

CDC weight-based dose: 20 mg/kg/dose twice daily, maximum 500 mg per dose.

Kidney impairment

Adjust using the cephalexin renal dosing table

CrCl 30–59: maximum 1 g/day; lower clearance requires a different dose/interval.

Before prescribing

Confirm GAS and document the allergy phenotype. Avoid cephalexin with immediate penicillin hypersensitivity or severe delayed beta-lactam reactions; select another treatment and arrange allergy evaluation when appropriate. Review renal function.

Side effects and return precautions

GI upset, rash and C. difficile diarrhea. Inability to swallow fluids, drooling or rapidly worsening swelling needs urgent assessment; breathing difficulty is an emergency.

Follow-up

Reassess if worsening or not improving in 48–72 hours.

Sources

Checked September 23, 2026.

Cephalexin (Keflex)Uncomplicated cystitis

What to say

For this bladder infection, take cephalexin 500 milligrams twice a day for 7 days, with or without food. We chose it because the usual first-choice antibiotics aren’t a good fit for you right now. It can work a little less reliably than those, so we’ll check the urine culture and tell you whether to continue or switch.

Symptoms should start easing within about 2 days. Call the same day if you aren’t improving, or if you develop fever, pain in your side or back, or vomiting. Nausea or loose stools can happen. Stop it and call the same day for a new rash. Trouble breathing or swelling of your lips or tongue means stop it and call 911. Severe watery or bloody diarrhea needs a same-day call, even weeks after the last dose. If you take metformin, tell us, because cephalexin can raise its level.

Clinical reference

Dose options

Uncomplicated cystitis when first-line agents are unsuitable

500 mg orally twice daily for 7 days

IDSA 2010: β-lactams 3–7 days are less effective than other agents; cephalexin is less well studied (B-III). Label: 500 mg every 12 hours for 7–14 days; 7 days fits both.

Renal adjustment (label)

CrCl 30–59: max 1 g/day; 15–29: 250 mg every 8–12 hours; 5–14: 250 mg every 24 hours

500 mg twice daily suits CrCl ≥30. Fever, flank pain or systemic illness needs a pyelonephritis regimen instead.

Before prescribing

Confirm lower-tract cystitis in a nonpregnant woman and why nitrofurantoin, TMP/SMX, fosfomycin or pivmecillinam won’t work. Review β-lactam reaction history, renal function, metformin and prior cultures; send a culture.

Side effects and return precautions

GI upset, rash, genital candidiasis. Anaphylaxis or blistering/mucosal rash needs emergency care. C. difficile diarrhea can appear weeks later. Fever, flank pain or vomiting suggests upper-tract infection.

Follow-up

Act on culture and susceptibilities; switch if resistant or not improving by 48 hours. No test-of-cure after resolution. Recurrent cystitis needs a culture-guided plan.

Sources

Checked October 15, 2026.

Cetirizine (Zyrtec)Allergic rhinitis

What to say

Cetirizine can help with sneezing, itching and a runny nose. Start 5 milligrams once a day. If that isn’t enough, we can discuss whether 10 milligrams is appropriate for you.

It can make you sleepy, even though it’s often sold as an allergy medicine that’s less likely to cause sleepiness. See how you feel before driving, and avoid combining it with alcohol or other sedating medicines. We’ll review whether it’s helping in a couple of weeks. If you use it daily for months or years, stopping can rarely cause severe itching. Contact us if that happens.

Clinical reference

Dose options

Usual allergy dose

5–10 mg orally once daily

Routine allergy maximum 10 mg/day; higher-dose urticaria regimens require a separate plan.

Older adults / organ impairment

The 5-mg OTC label limits adults ≥65 years to 5 mg/day

Kidney or liver disease requires individualized clinician dosing; check the dispensed product.

Before prescribing

Review age, kidney/liver function, sedatives, alcohol and pregnancy/breastfeeding. Match the product strength to the prescription.

Side effects and return precautions

Drowsiness and dry mouth; rare severe itching after discontinuing long-term daily use. Breathing trouble or tongue swelling: call 911; cetirizine does not replace emergency anaphylaxis treatment.

Follow-up

Practical review in 1–2 weeks for benefit and sedation; reassess ongoing daily need. No routine lab monitoring solely for routine use.

Sources

Checked September 20, 2026.

Cetirizine (Zyrtec)Hives (urticaria)

What to say

Cetirizine can reduce itching and raised welts from hives. For this plan, take 10 milligrams once daily. We may use a lower dose based on your age, kidney or liver function, or side effects. Don’t take extra doses without a separate plan.

It may make you sleepy, so be careful with driving and avoid alcohol or other sedatives. Hives with trouble breathing, throat swelling or faintness may be anaphylaxis: use your prescribed epinephrine and call 911. Cetirizine isn’t a substitute. Contact us if symptoms aren’t improving after three days, or if hives keep returning.

Clinical reference

Dose options

Adult hives treatment

10 mg once daily; 5 mg may suffice for milder symptoms

Older adults and renal/hepatic impairment need individualized dosing. Higher-dose chronic urticaria treatment needs a separate clinician-directed plan.

Before prescribing

Confirm urticaria and exclude anaphylaxis or another rash. Review new medicines, triggers, duration, renal/hepatic function and sedation risk. Persistent lesions, bruising or systemic symptoms need diagnostic reassessment.

Side effects and return precautions

Sedation may occur. Angioedema or systemic allergy symptoms require an emergency plan. Rare severe itching can occur after stopping long-term daily cetirizine; discuss a stopping plan if used for months or years.

Follow-up

Reassess if not improving within three days; hives lasting beyond six weeks need a chronic-urticaria assessment and individualized step-up plan.

Sources

Checked September 23, 2026.

Cevimeline (Evoxac)Dry mouth in Sjögren’s disease

What to say

Cevimeline helps your glands make more saliva to ease dry mouth from Sjögren’s disease. Take one 30-milligram capsule 3 times a day, with or without food. Give it a few weeks; we’ll check in on [date]. Keep sipping water, use sugar-free gum or lozenges, and use fluoride as your dentist advises, since dry mouth raises cavity risk.

Sweating is the most common side effect, so drink extra water, especially in hot weather. Nausea and a runny nose can also happen. It can blur vision at night, so take care driving in the dark. Tell us if you have asthma, COPD, glaucoma, heart disease, or gallstones or kidney stones, and check with us before new medicines, since some raise its level. Stop it and call us the same day for wheezing, a slow or irregular heartbeat, or severe belly or side pain. Call 911 for severe trouble breathing, chest pain or fainting.

Clinical reference

Dose options

Dry mouth in Sjögren’s disease

30 mg orally three times daily, with or without food

Label: no safety data or added benefit above 30 mg three times daily. Food slows absorption (peak about 17% lower). Trials ran 6–12 weeks; 14.6% stopped for adverse events.

Interactions and organ function

Use caution with CYP2D6 or CYP3A4 inhibitors, known CYP2D6 poor metabolizers and beta-blockers

Effects add to other parasympathomimetics such as pilocarpine; anticholinergics may blunt it. Renal and hepatic impairment weren’t studied, and about 97% of a dose is excreted in urine, so take special care, as in older adults.

  • Sjögren’s Foundation guideline (weak, expert opinion): stimulate saliva with sugar-free gum or lozenges, xylitol, pilocarpine or cevimeline, and use topical fluoride in patients with dry mouth. EULAR 2019 also covers oral muscarinic agonists.

Before prescribing

Confirm dry mouth from Sjögren’s; benefit needs some remaining gland function. Contraindicated: uncontrolled asthma, acute iritis, narrow-angle glaucoma, hypersensitivity. Use caution with heart disease, controlled asthma or COPD, gallstones or kidney stones, beta-blockers, CYP2D6/3A4 inhibitors, pregnancy and breastfeeding.

Side effects and return precautions

Sweating (18.7% vs 2.4% on placebo), nausea, rhinitis; dehydration in heat; night-vision blurring. Cholinergic excess: lacrimation, GI cramping, bronchospasm, bradycardia or AV block, hypotension, confusion, tremor. Biliary or renal colic with stones.

Follow-up

Reassess dry mouth and side effects at 6–12 weeks; stop if there’s no clear benefit. Continue sugar-free saliva stimulants, topical fluoride and regular dental visits; review dry eyes.

Sources

Checked October 20, 2026.

CGRP antibody injection (Aimovig, Emgality, Ajovy)Migraine prevention

What to say

This shot under the skin prevents migraines by blocking CGRP, a chemical involved in attacks. Your plan is [medicine, dose and schedule]. Let the pen sit out of the fridge for 30 minutes first, and don’t shake it. Inject into your belly, thigh or upper arm. If you miss a dose, give it when you remember, then count the next from that date. Keep your plan for attacks and a headache diary; we’ll judge the effect after about 3 months.

Injection-site soreness is common. Constipation can happen; call us the same day if it comes with belly pain, swelling or vomiting. Check your blood pressure in the first week and tell us if it’s higher than usual. Fingers or toes that turn white or blue and hurt mean call us before the next dose. Call 911 for face or throat swelling or trouble breathing. It stays in your body for months, so tell us before trying to get pregnant.

Clinical reference

Dose options

Erenumab (Aimovig)

70 mg SC once monthly; some patients benefit from 140 mg monthly

Blocks the CGRP receptor. Constipation was more frequent at 140 mg (3% vs 1% with placebo).

Galcanezumab (Emgality)

240 mg SC once (two 120-mg injections), then 120 mg monthly

Episodic cluster headache uses a different regimen.

Fremanezumab (Ajovy)

225 mg SC monthly, or 675 mg (three 225-mg injections) every 3 months

When switching between regimens, give the first dose of the new regimen on the next scheduled date.

  • All three labels now warn of constipation with serious complications, hypertension and Raynaud phenomenon. The 2026 AAN/AHS guideline lists all CGRP antibodies, including IV eptinezumab (Vyepti), as higher-confidence options for episodic and chronic migraine.

Before prescribing

Offer for ≥4 migraine days a month or disabling migraine (AAN/AHS 2026). Check BP and hypertension history, Raynaud phenomenon, severe constipation or motility-slowing drugs (opioids, anticholinergics), prior hypersensitivity, pregnancy plans (long half-life) and prior authorization.

Side effects and return precautions

Injection-site reactions; constipation, sometimes needing hospitalization or surgery; new or worsened hypertension, often within 7 days of starting; Raynaud phenomenon (median onset 71 days); hypersensitivity that can be delayed.

Follow-up

Check BP after the first dose. Review the diary and acute-medication days at 8–12 weeks; consider switching if response is still suboptimal by 12–24 weeks. Discuss tapering after 6 months of good control.

Sources

Checked October 15, 2026.

Chlordiazepoxide (Librium)Outpatient alcohol withdrawal

What to say

Chlordiazepoxide eases alcohol withdrawal and helps prevent seizures. Start only after you’ve stopped drinking and no longer feel any alcohol: take 2 capsules (50 milligrams) every 6 hours on day 1, every 8 hours on day 2, every 12 hours on day 3 and at bedtime on day 4. Take up to [number] extra doses for worse shakes; skip a dose if you’re very sleepy. Take thiamine (vitamin B1) 100 milligrams daily. We’ll check in every day.

It can cause sleepiness and unsteadiness, so don’t drive. Mixing it with alcohol, opioids or other sedatives can stop your breathing. Keep it secure. Call us the same day for uncontrolled shaking, vomiting or drinking again. Call 911 for a seizure, confusion, seeing things that aren’t there, fainting, a high fever, or if someone is hard to wake or breathing slowly. For suicidal thoughts, call or text 988. We’ll also offer medicine to help you stay off alcohol.

Clinical reference

Dose options

Fixed-dose taper (ASAM example)

Day 1: 25–100 mg orally every 4–6 h; day 2: every 6–8 h; day 3: every 8–12 h; day 4 (± day 5): at bedtime

Cut the daily total by 25–50% a day over 3–5 days, e.g., 50 mg every 6, 8 and 12 h, then 50 mg at bedtime. Give a few PRN take-home doses and review the next day. Label maximum 300 mg/day.

Symptom-triggered dosing

25–100 mg every 4–6 h when CIWA-Ar ≥10

In office-based care, only if the patient or a caregiver can reliably score symptoms with a withdrawal scale (e.g., SAWS) and follow dosing guidance; otherwise use fixed dosing with PRN doses.

Liver disease, older adults, alternatives

Significant liver disease: lower the dose or use a benzodiazepine with less hepatic metabolism, such as lorazepam

Older age raises the risk of complicated withdrawal; use the smallest effective dose. Mild withdrawal (CIWA-Ar <10): supportive care alone, gabapentin or carbamazepine; gabapentin suits patients continuing it for AUD. Diazepam is another long-acting option.

  • ASAM 2020: no benzodiazepine is more effective than another, but longer-acting ones such as chlordiazepoxide (half-life 24–48 h) or diazepam give a smoother course, with better control of breakthrough and rebound symptoms.

Before prescribing

ASAM office-based care suits mild withdrawal (CIWA-Ar <10; 10–18 uncertain) in a patient who isn’t intoxicated, without recent withdrawal seizures or delirium, benzodiazepine dependence, suicide risk or unstable illness, with oral intake, daily check-ins and support. Check CURES, opioids, CMP/LFTs, CBC, pregnancy.

Side effects and return precautions

Oversedation and respiratory depression (opioids, alcohol, liver disease, older age). Escalate care for persistent vomiting, uncontrolled tremor or agitation, hallucinations, confusion, seizure, syncope, unstable vital signs, oversedation or return to drinking.

Follow-up

Check in daily for up to 5 days after the last drink (phone or video can alternate with visits): vitals, withdrawal score, sedation, mood and suicidality, alcohol use. Stop the benzodiazepine after withdrawal; offer AUD medication.

Sources

Checked October 21, 2026.

Chlorthalidone (Hemiclor)Hypertension

What to say

We’re starting chlorthalidone 12.5 milligrams each morning with food to lower blood pressure. It helps your body get rid of extra salt and water. Morning dosing makes nighttime bathroom trips less likely.

You may pee more or feel dizzy when standing, especially at first. Follow your usual fluid plan. We’ll check sodium, potassium and kidney function in the next few weeks because changes can happen without obvious symptoms. Call the same day for marked weakness, troublesome cramps, a racing heartbeat or an illness that prevents normal drinking. Tell us about a painful red joint, which could be gout. Bring your home pressure readings to our review in about a month.

Clinical reference

Dose options

Hypertension start

12.5–25 mg orally once daily

The Hemiclor label supports starting at 12.5 mg; confirm the dispensed product allows the intended dose.

Titration

May double every 2–4 weeks if needed; usual primary-care doses 12.5–25 mg daily

Label maximum 100 mg/day; higher doses increase electrolyte and metabolic effects and are not a routine escalation target.

Kidney / electrolyte context

Contraindicated in anuria; assess renal function and volume status

Use individualized monitoring in CKD rather than assuming a thiazide-like drug is universally ineffective.

Before prescribing

Check BP, sodium/potassium, renal function, gout, pregnancy, volume status and interacting drugs. Review other diuretics and lithium; do not automatically add potassium.

Side effects and return precautions

Polyuria, orthostasis, low sodium/potassium, gout and photosensitivity. Severe confusion, seizure, collapse or severe chest/breathing symptoms require emergency care.

Follow-up

Practical BP/electrolyte/renal review within 2–4 weeks, earlier with risk factors; reassess after dose changes and acute volume-depleting illness.

Sources

Checked September 20, 2026.

Ciprofloxacin (Cipro)Acute bacterial prostatitis

What to say

This antibiotic treats a bacterial infection of the prostate. Take ciprofloxacin 500 milligrams twice a day, about 12 hours apart, for at least two weeks; we may extend it to four weeks depending on your response and culture. Drink plenty of fluids. Take it two hours before or six hours after antacids, calcium, iron, zinc or multivitamins, and not with dairy alone.

Nausea and diarrhea can happen. Stop it and call us the same day for tendon pain or swelling, numbness or tingling, mood changes, or new muscle weakness. Call the same day if you aren’t improving within two days or can’t keep pills down. If you can’t pass urine, or have shaking chills, fainting or confusion, go to the emergency department. Sudden severe chest, belly or back pain means call 911. It can raise or lower blood sugar and interacts with tizanidine and theophylline, so check before new medicines. Limit sun exposure.

Clinical reference

Dose options

Acute bacterial prostatitis, outpatient

Ciprofloxacin 500 mg orally every 12 hours for at least 14 days, up to 4 weeks total

AAFP 2024 recommends 2 weeks; EAU advises 2–4 weeks total. Label durations are 7–14 days for UTI and 28 days for chronic bacterial prostatitis. Tailor to culture; TMP-SMX DS twice daily is an alternative when susceptible.

Renal adjustment (label)

CrCl 30–50 mL/min: 250–500 mg every 12 hours; 5–29: 250–500 mg every 18 hours; hemodialysis or peritoneal dialysis: 250–500 mg every 24 hours, after dialysis

Keep patients well hydrated; crystalluria can occur with alkaline urine.

Systemically ill

Parenteral therapy first, then oral once improving to complete 2–4 weeks

EAU prefers parenteral treatment when systemically ill. Urinary retention needs same-day catheter drainage (urethral or suprapubic).

Before prescribing

Send urine culture (blood cultures if unwell) before starting; avoid prostatic massage. Test for gonorrhea and chlamydia with STI risk. Check renal function, QT risk, aortic aneurysm, myasthenia gravis, tendon disorders or prior fluoroquinolone reactions, steroids, age >60, diabetes drugs, tizanidine and theophylline.

Side effects and return precautions

Boxed warnings: tendinitis or rupture, peripheral neuropathy, CNS and psychiatric effects, myasthenia exacerbation. Also aortic aneurysm or dissection, dysglycemia, QT prolongation, C. difficile, photosensitivity, hepatotoxicity. Retention, persistent fever or sepsis needs urgent review.

Follow-up

Review early (about 48 hours) and adjust to culture. Severe symptoms or slow improvement: image for prostatic abscess. Consider post-void residual for obstructive symptoms. No routine test of cure if asymptomatic; symptoms beyond 3 months need chronic prostatitis evaluation.

Sources

Checked October 15, 2026.

Ciprofloxacin (Cipro)Kidney infection

What to say

You have a kidney infection. We’ve sent a urine culture to confirm this antibiotic fits the germ, and we may change it when results return. Take ciprofloxacin 500 milligrams twice a day, about 12 hours apart, for 7 days. Take it at least 2 hours before or 6 hours after antacids or calcium, iron or zinc products, and not with only milk or yogurt.

You should feel better within 2 to 3 days; call if you don’t. Go to the emergency department if you can’t keep pills or fluids down, feel faint or become confused. Rarely, this medicine harms tendons or nerves or affects mood. Stop it and call for tendon pain, tingling or numbness, or mood changes. Sudden severe chest, belly or back pain needs emergency care. It can cause high or low blood sugar and easier sunburn. Tell us if you take tizanidine, theophylline, warfarin or diabetes medicines, or could be pregnant.

Clinical reference

Dose options

Acute pyelonephritis, outpatient, nonpregnant adult

500 mg orally twice daily for 7 days

IDSA 2025 (pyelonephritis is classed as complicated UTI): 5–7 days of a fluoroquinolone when improving. EAU: 500–750 mg twice daily for 7 days, empirically only where fluoroquinolone resistance is <10%. Label: 7–14 days.

Higher resistance risk (local resistance >10%, prior resistant isolate or recent fluoroquinolone use)

Choose another empiric agent or add an initial long-acting parenteral dose (e.g., ceftriaxone) pending culture

IDSA 2025 selects empiric therapy by severity, resistance risk, patient factors and antibiogram. Adjust to susceptibility results.

Renal adjustment

CrCl 30–50 mL/min: 250–500 mg every 12 hours; 5–29: 250–500 mg every 18 hours; dialysis: 250–500 mg every 24 hours after dialysis

Per label.

  • Label: reserve ciprofloxacin for uncomplicated cystitis only when no alternatives exist; pyelonephritis remains a labeled use.

Before prescribing

Culture first; exclude sepsis, obstruction and pregnancy. Boxed warnings: tendinopathy (age >60, steroids, transplant), neuropathy, CNS effects, myasthenia gravis. Avoid with aortic aneurysm risk or QT drugs. Tizanidine contraindicated; check theophylline, warfarin, glucose-lowering drugs, clozapine.

Side effects and return precautions

Tendon pain/rupture, neuropathy, psychiatric effects, dysglycemia, QT prolongation, aortic dissection, C. difficile, photosensitivity, hypersensitivity. Vomiting, hypotension or bacteremia signs need ED care and IV therapy.

Follow-up

Review response at 48–72 hours and culture results; switch if resistant. Still febrile after 72 hours or deteriorating: imaging (e.g., contrast CT) for obstruction or abscess.

Sources

Checked October 15, 2026.

Ciprofloxacin/dexamethasone ear drops (Ciprodex)Otitis externa

What to say

These drops treat the infection and swelling in your ear canal. For this infection, drops work better than antibiotic pills, and they’re safe even if your eardrum has a hole. Shake the bottle and warm it in your hand for 1–2 minutes; cold drops can cause dizziness. Lie with the sore ear up, put in 4 drops, gently pull the outer ear up and back, and stay lying down for 3–5 minutes. Use them twice a day for 7 days.

Keep water out of the ear and don’t swim for about a week. Don’t put swabs, earbuds or anything else in the ear. Acetaminophen or ibuprofen can ease the pain. Call us if you’re not better in 2–3 days or not well after 7 days. Get same-day care for severe or worsening pain, fever, spreading redness or swelling around the ear, or facial weakness, especially with diabetes or a weak immune system. Stop the drops and call for a rash.

Clinical reference

Dose options

Acute otitis externa

4 drops into the affected ear twice daily for 7 days

Labeled regimen (age 6 months and older). The label says to keep the ear up for 60 seconds; guideline teaching uses 3–5 minutes. Shake well and warm the bottle first.

Alternative quinolone drop

Ofloxacin 0.3%: 10 drops once daily for 7 days (age 13 and older)

Quinolone drops are non-ototoxic and suit a known or suspected perforation or tympanostomy tube; avoid aminoglycoside (neomycin) drops unless the eardrum is known to be intact.

Swollen or blocked canal

Aural toilet under direct vision and/or a wick so drops reach the canal

Avoid irrigation if the eardrum may not be intact or the patient has diabetes. Add systemic antibiotics only for spread beyond the canal or high-risk hosts.

  • AAO-HNSF 2014: topical drops first; no systemic antibiotics for uncomplicated AOE unless infection extends beyond the canal or host factors such as diabetes, immunocompromise or prior radiotherapy are present.

Before prescribing

Confirm diffuse AOE (tragal tenderness, canal edema) vs. otitis media, furuncle, otomycosis or zoster oticus; the label contraindicates fungal or viral canal infection. Assess eardrum integrity, diabetes, immunosuppression, prior radiotherapy, quinolone allergy.

Side effects and return precautions

Ear discomfort or itching; stop for rash or hypersensitivity. Prolonged use risks fungal overgrowth. Severe pain, granulation tissue, cranial nerve palsy or fever in diabetic, immunocompromised or older patients: suspect necrotizing otitis externa; urgent ENT.

Follow-up

Reassess at 48–72 hours if not improving (adherence, delivery, diagnosis); culture if not better after 1 week. Persistent otorrhea or 2 or more episodes in 6 months: evaluate for cholesteatoma, foreign body or tumor.

Sources

Checked October 15, 2026.

Citalopram (Celexa)Depression

What to say

For depression, start citalopram 20 milligrams once daily, with or without food. Take it every day. If needed, we may increase to 40 milligrams after at least a week, but people over 60 stay at 20 milligrams or less. Sleep or appetite may improve before mood, which can take several weeks.

Nausea, dry mouth, sweating, sleepiness or trouble sleeping can happen early, and sexual side effects can occur; tell us rather than stopping. Higher doses can affect heart rhythm, so check with us before new medicines, and get urgent care for fainting or a pounding, irregular heartbeat. Ask before using NSAIDs like ibuprofen or blood thinners. Call the same day for thoughts of self-harm, severe restlessness, or very high energy with little sleep. If you might act on those thoughts, call 911; you can also call or text 988. Don’t stop suddenly.

Clinical reference

Dose options

Adult depression

20 mg orally once daily; may increase to 40 mg after ≥1 week

Doses above 40 mg/day are not recommended because of dose-dependent QTc prolongation.

Maximum 20 mg/day

Age >60, hepatic impairment, CYP2C19 poor metabolizers, or with cimetidine or another CYP2C19 inhibitor

Higher citalopram exposure expected; limits reflect the FDA QT safety revisions now in the label.

Stopping

Taper gradually rather than stopping abruptly

Discontinuation symptoms can occur. Continue at least 6 months after remission before considering a taper (NICE).

Before prescribing

Assess suicide risk and bipolar history. Avoid with congenital long QT, bradycardia, recent MI, uncompensated HF or other QT-prolonging drugs; correct low K/Mg; ECG if used despite risk. No MAOIs or pimozide.

Side effects and return precautions

GI, sleep, sweating and sexual effects; activation/mania, suicidality (boxed warning under 25), serotonin syndrome, bleeding with NSAIDs/anticoagulants, hyponatremia, angle closure. Stop if QTc persistently >500 ms.

Follow-up

Review within 2 weeks; 1 week if aged 18–25 or at higher suicide risk. Evaluate palpitations or syncope with ECG. Reassess benefit over weeks; continue ≥6 months after remission, then taper.

Sources

Checked October 15, 2026.

Clarithromycin (Biaxin)Susceptible bacterial infection

What to say

We’ve chosen clarithromycin for [bacterial infection]. Take [prescribed dose] every twelve hours for [number of days], through [stop date]. These are the regular-release tablets, which you can take with or without food. Follow the full prescribed course unless we tell you to change it.

Nausea, loose stools or a changed taste can happen. Check with us before adding or changing medicines because this antibiotic has important interactions. Call promptly for severe or bloody diarrhea, even after finishing, or for yellow eyes or dark urine. Stop it and get emergency care for trouble breathing, facial swelling, a blistering rash, or fainting with a racing or irregular heartbeat. Call if you’re worsening or not improving over the next few days.

Clinical reference

Dose options

Adult immediate-release label range

250 or 500 mg orally every 12 hours; labeled courses commonly 7–14 days depending on infection

Specify diagnosis, dose and duration using current infection-specific guidance and susceptibility; this is not a universal antibiotic regimen.

Renal adjustment

CrCl <30 mL/min: reduce dose by 50%

Atazanavir or ritonavir combinations require additional label-specific adjustment. Extended-release tablets use different instructions.

Before prescribing

Review macrolide allergy, prior clarithromycin-associated liver injury, pregnancy, renal function, QT risk/electrolytes and coronary disease; consider alternatives in CAD. Check the complete interaction list, including simvastatin/lovastatin, colchicine, antiarrhythmics, warfarin, digoxin and calcium-channel blockers. Colchicine with renal/hepatic impairment is contraindicated.

Side effects and return precautions

GI effects, altered taste, C. difficile diarrhea, hepatotoxicity and QT-related arrhythmia; potentially serious CYP3A-mediated interactions.

Follow-up

Reassess lack of improvement in the first few days, sooner if worsening. Review cultures and any required INR or other interaction monitoring.

Sources

Checked September 24, 2026.

Clindamycin (Cleocin)Cellulitis with a serious penicillin allergy

What to say

Because of your serious penicillin allergy, we’re treating this skin infection with clindamycin. Take [300 or 450] milligrams 4 times a day, about every 6 hours, for 5 days. Swallow each dose with a full glass of water and stay upright for at least 30 minutes to protect your throat. Raise the affected arm or leg when you can. We’ll mark the edge of the redness; it should start improving within 2–3 days.

Call the same day if redness spreads, pain worsens or fever starts. Diarrhea is common, but call the same day for watery or bloody diarrhea or cramps, even up to 2 months later; it can be a serious infection called C. diff. Stop it and call us for a new rash. For blistering, peeling or mouth sores, go to the emergency department; for trouble breathing or face swelling, call 911. A later allergy evaluation may show penicillin is safe.

Clinical reference

Dose options

Nonpurulent cellulitis with severe beta-lactam allergy

300–450 mg orally every 6 hours (4 times daily) for 5 days; extend if not improved

IDSA oral dose and duration; IDSA lists clindamycin for severe penicillin hypersensitivity. The label gives 150–450 mg every 6 hours and at least 10 days for beta-hemolytic streptococcal infection.

Administration and organ function

Full glass of water; stay upright for 30 minutes; no renal or age adjustment

Esophagitis and ulcer risk if taken lying down or with little water. Not removed by dialysis. AKI has been reported: stop if no other cause.

Before prescribing

Clarify the reaction: most penicillin labels aren’t true allergy on evaluation, so a beta-lactam may still fit; SJS/TEN histories need specialist input. Assess drainage needs, MRSA risk, systemic signs, prior C. difficile and strong CYP3A4 inducers or inhibitors.

Side effects and return precautions

Diarrhea and C. difficile infection (boxed warning; can occur more than 2 months later), esophagitis, metallic taste, morbilliform rash; anaphylaxis, SJS/TEN, DRESS, AGEP; AKI. Inducible MRSA resistance; use the local antibiogram.

Follow-up

Reassess in 48–72 hours, sooner if worse; extend beyond 5 days only if not improved (IDSA). Elevate and treat edema or toe-web maceration. Refer for penicillin allergy evaluation.

Sources

Checked October 15, 2026.

Clindamycin 1% topical (Cleocin T)Hidradenitis suppurativa, off-label

What to say

For hidradenitis suppurativa, apply a thin layer of clindamycin 1% solution or gel to the affected areas twice a day. This is an off-label use, meaning it isn’t listed on the package, but it can reduce pus bumps. It doesn’t clear deeper lumps. Wash daily with an antiseptic wash, such as benzoyl peroxide, which also helps prevent resistant bacteria. Quitting smoking can help too. We’ll check progress at 12 weeks.

Burning, dryness or irritation can happen. Keep the solution away from your eyes, mouth and broken skin. Rarely, even skin antibiotics can inflame the bowel. Stop it and call the same day for severe or bloody diarrhea or bad cramps. Call us about a painful swollen lump; some can be injected or drained. Fever with spreading redness needs a same-day visit. If flares continue, a dermatologist can offer stronger treatments, including pills and injections.

Clinical reference

Dose options

Mild HS (Hurley I–mild II), off-label

Clindamycin 1% solution or gel, thin film twice daily to lesions; reassess at 12 weeks

Labeled only for acne (twice daily). HS guideline: the only topical antibiotic studied; reduced pustules, not nodules or abscesses; high S. aureus resistance risk, which benzoyl peroxide may reduce.

Adjuncts

Antiseptic washes (chlorhexidine, benzoyl peroxide, zinc pyrithione); intralesional triamcinolone 10 mg/mL, 0.2–2.0 mL, for inflamed nodules

Washes rest on expert opinion. Moderate–severe disease needs systemic therapy via dermatology.

Before prescribing

Confirm HS and Hurley stage. Label contraindicates use after regional enteritis, ulcerative colitis or antibiotic-associated colitis. Counsel smoking cessation and weight loss where relevant; screen for metabolic comorbidities.

Side effects and return precautions

Local burning, itching, dryness, erythema. Diarrhea or colitis is rare but needs stopping and C. difficile evaluation. Abscess or cellulitis needs drainage or systemic treatment.

Follow-up

Reassess at 12 weeks and stop if no benefit. Refer to dermatology for Hurley II–III, tunnels or frequent flares; adalimumab, secukinumab and bimekizumab are FDA-approved for HS.

Sources

Checked October 15, 2026.

Clobetasol 0.05% (Temovate)Psoriasis plaques

What to say

Clobetasol is a very strong steroid for thick psoriasis plaques. Twice a day, rub a thin layer into the plaques only: cream or ointment on the body, solution or foam on the scalp. Use it for 2 weeks, then we’ll check; if plaques are better but not clear, we may continue 2 more weeks. Then we’ll step down, such as calcipotriene on weekdays and clobetasol on weekends. Don’t use more than 50 grams a week.

Don’t use it on your face, groin, armpits or skin folds, or cover it with plastic wrap or bandages unless we ask. Keep it out of your eyes, and wash your hands afterward unless treating them. Stinging is common. Longer use can thin the skin and cause stretch marks, and use over large areas can affect your body’s own steroid hormones. The foam is flammable. Call us if plaques spread, look infected or aren’t improving by 2 weeks. Widespread redness with fever needs same-day care.

Clinical reference

Dose options

Plaque psoriasis: cream, ointment or gel (body); solution or foam (scalp)

Thin layer twice daily for up to 2 consecutive weeks; no more than 50 g (or 50 mL) per week

Label limits. AAD-NPF 2021 supports class 1 steroids for up to 4 weeks on non-intertriginous plaques, and longer than 12 weeks only under close supervision.

Maintenance after improvement

Weekday calcipotriene with weekend high-potency steroid, or step down to a lower potency

AAD-NPF maintenance option; calcipotriene/corticosteroid combination products are also recommended. Continue emollients.

Before prescribing

Confirm plaque psoriasis (vs. tinea or eczema) without site infection. Avoid face, groin, axillae, skin folds and atrophic skin; no occlusion. Large areas or long courses raise HPA-suppression risk. Not under age 12; in pregnancy, limit area and duration.

Side effects and return precautions

Burning, atrophy, striae, telangiectasia, folliculitis, contact dermatitis; HPA suppression or Cushing syndrome with extensive use; glaucoma or cataract with periocular use. Widespread erythema or pustules with systemic symptoms needs urgent review.

Follow-up

Review at 2 weeks; reassess the diagnosis if not improving, and set a maintenance plan. Extensive or refractory disease: dermatology for phototherapy or systemic therapy. Ask about joint symptoms.

Sources

Checked October 15, 2026.

Clonazepam (Klonopin)Panic disorder

What to say

Clonazepam calms panic quickly. We’re using it for a few weeks while your antidepressant and therapy start working. Take half a 0.5-milligram tablet (0.25 milligrams) in the morning and at bedtime for 3 days, then a whole tablet twice a day. Take it on schedule, not as needed. We’ll lower it slowly and stop by [date].

It can cause sleepiness and unsteadiness, so don’t drive until you know how it affects you. Don’t mix it with alcohol, opioids or other sedatives; together they can stop your breathing. Keep it locked away. Call us the same day if you feel more depressed or agitated. For thoughts of suicide, call or text 988; call 911 if you might act on them, or if someone is hard to wake or breathing slowly. Don’t stop suddenly, because withdrawal can cause seizures. Tell us if you’re pregnant or planning pregnancy.

Clinical reference

Dose options

Adult panic disorder

0.25 mg orally twice daily; after 3 days, 0.5 mg twice daily (1 mg/day target)

Label: 1 mg/day worked best in the fixed-dose trial; 2–4 mg/day were less effective, with more adverse effects. If needed, raise by 0.125–0.25 mg twice daily every 3 days; maximum 4 mg/day. A bedtime dose limits daytime somnolence.

Short-term bridge with an SSRI or SNRI

Start with the antidepressant; plan under 8 weeks in total, including the taper

Canadian 2014 guideline: short-term clonazepam at SSRI start speeds response. Label: efficacy beyond 9 weeks not studied; reassess periodically if continued.

Stopping; older adults; organ impairment

Label taper: reduce by 0.125 mg twice daily every 3 days until stopped

Suits a short course. After long-term regular use, the 2025 joint guideline tapers far more slowly; see the long-term benzodiazepine card. Older adults: start low (Beers: avoid). Contraindicated in significant liver disease; caution in renal impairment.

  • Second-line for panic disorder (Canadian 2014); NICE advises against benzodiazepines for panic disorder because of poorer long-term outcomes. Half-life 30–40 h, vs about 11 h for alprazolam, allows twice-daily dosing.

Before prescribing

Confirm panic disorder and start an SSRI/SNRI or CBT. Check CURES, alcohol, opioid and sedative use, substance use history, depression and suicidality, sleep apnea/COPD, falls and pregnancy. Contraindicated: significant liver disease, acute narrow-angle glaucoma. Offer naloxone with opioids.

Side effects and return precautions

Somnolence (37% vs 10% placebo), ataxia, memory problems, falls; new depression or suicidality (antiseizure-drug warning); paradoxical agitation; misuse; respiratory depression with opioids or alcohol. Azole antifungals may raise levels; CYP inducers lower them about 38%.

Follow-up

Review within 1–2 weeks and at each refill: panic frequency, sedation, use pattern and antidepressant response. Taper once the antidepressant works; if use becomes long term, follow the long-term benzodiazepine card.

Sources

Checked October 21, 2026.

Clonidine IR (Catapres)Hypertension

What to say

Take your prescribed clonidine dose every morning and at bedtime, even when you feel well. We’ll write down your blood-pressure and pulse targets and when to call. It can cause sleepiness, dry mouth, constipation or dizziness when standing. Rise slowly and avoid driving until you know how it affects you.

Don’t stop clonidine suddenly: your blood pressure can rise dangerously. Call us promptly if you’re running out or vomiting prevents you from taking it. Don’t double a missed dose. If we need to stop it, we’ll give you a taper. Call 911 for chest pain, fainting, severe breathlessness, or new weakness or trouble speaking.

Clinical reference

Dose options

Adult initial label dose

Immediate-release tablet: 0.1 mg orally twice daily

Older adults and patients with renal impairment may need a lower starting dose; individualize to BP and pulse.

Titration / discontinuation

Clinician-directed adjustment; commonly 0.2–0.6 mg/day in divided doses

Label permits weekly increases of 0.1 mg/day. Taper rather than abruptly stopping; coordinate any beta-blocker withdrawal first under supervision.

Before prescribing

Check BP, pulse, orthostasis, conduction disease, kidney function and adherence/refill access. Review beta-blockers, verapamil/diltiazem, digoxin and sedatives. Confirm immediate-release formulation; patches and extended-release ADHD products have different instructions.

Side effects and return precautions

Sedation, dry mouth, constipation, hypotension and bradycardia. Abrupt withdrawal can cause severe rebound hypertension.

Follow-up

Review home BP/pulse and tolerance within the agreed titration interval, usually about a week. Provide a missed-dose and refill plan. The IR label describes a 2–4-day taper; individualize duration and monitoring.

Sources

Checked September 24, 2026.

Clopidogrel (Plavix)After coronary stenting or acute coronary syndrome

What to say

Continue clopidogrel 75 milligrams once daily as prescribed by your heart team to help prevent another clot, including a clot in the stent if you have one. Your written plan says whether to take aspirin too, at what dose, and when each medicine will be reviewed. Don’t add aspirin or stop either medicine on your own.

Bruising and bleeding can occur. Call 911 for uncontrolled bleeding or new persistent chest pain. Vomiting blood or black, sticky stools needs emergency assessment. Contact the heart team before dental work or surgery so they can coordinate any interruption. Tell us promptly if cost or running out could cause missed doses.

Clinical reference

Dose options

Established outpatient maintenance plan

75 mg orally once daily after the treating team’s initiation/loading plan

Aspirin combination and duration depend on ACS, PCI, bleeding risk and any anticoagulant. This is not an acute loading protocol or a universal DAPT stop date.

Before prescribing

Reconcile the discharge/PCI plan, indication, date, loading already given, aspirin and anticoagulants, bleeding history, CYP2C19 concerns and interactions. Avoid omeprazole/esomeprazole; select GI protection appropriately.

Side effects and return precautions

Major bleeding or stroke symptoms need emergency care. Recurrent nose/gum bleeding needs prompt contact. Rare TTP may cause fever, neurologic symptoms and unusual bruising. Coordinate any interruption with the prescribing team, particularly after stenting.

Follow-up

Confirm the written antiplatelet review/stop dates and refills with cardiology. Reassess bleeding and adherence early; coordinate every planned interruption.

Sources

Checked September 23, 2026.

Clopidogrel (Plavix)Secondary prevention after ischemic stroke

What to say

I’m starting clopidogrel 75 milligrams once a day to reduce your chance of another clot after your stroke caused by a blood clot. Take it with or without food. You may bruise more easily and small cuts may take longer to stop bleeding. Don’t add aspirin, ibuprofen, naproxen, or an over-the-counter heartburn medicine without checking with us.

Call 911 for heavy bleeding that won’t stop, vomiting blood with weakness, or a drooping face, arm weakness or trouble speaking. Go to the emergency department for black, sticky stools. Tell your dentist and other clinicians you take this, but don’t stop it for a procedure on your own. If you miss a dose, take it when remembered unless the next is close. Don’t double. We’ll review bleeding and the medication plan in two weeks, including whether you should also take aspirin and for how long.

Clinical reference

Dose options

Secondary prevention after ischemic stroke

75 mg orally once daily

Maintenance dose only; it does not cover acute loading or a short-term dual-antiplatelet stroke pathway.

Renal / hepatic considerations

No standard label dose reduction

Experience in moderate/severe renal impairment is limited; assess bleeding and liver disease individually.

Before prescribing

Confirm ischemic indication, bleeding/CBC history, concurrent anticoagulants/antiplatelets and procedure plans. Active pathological bleeding is contraindicated. Avoid omeprazole/esomeprazole; assess CYP2C19 poor-metabolizer status when clinically relevant.

Side effects and return precautions

Major bleeding or stroke symptoms need emergency care. Recurrent nose/gum bleeding needs prompt contact. Rare TTP may cause fever, neurologic symptoms and unusual bruising. Coordinate any interruption with the prescribing team, particularly after stenting.

Follow-up

Arrange an early bleeding and adherence review, such as at two weeks. Record antiplatelet indication, aspirin plan and planned reassessment. CBC if bleeding or anemia is suspected; INR is not a clopidogrel monitoring test.

Sources

Checked September 23, 2026.

Clotrimazole 1% cream (Lotrimin AF)Fungal skin infection

What to say

This cream treats the fungus causing your ringworm. Wash the area, dry it thoroughly, and apply a thin layer of clotrimazole 1% cream morning and evening for four weeks. Keep using it for the planned course even if the itching settles sooner.

Use it only on the skin and keep it out of your eyes and mouth. Call if the rash worsens or the cream causes significant burning or irritation. If it hasn’t improved after four weeks, we need to check the diagnosis. Scalp and nail infections need a different plan.

Clinical reference

Dose options

Ringworm / athlete’s foot

1% cream: thin layer twice daily for 4 weeks

For feet, include between the toes; keep feet dry and change socks daily.

Jock itch

1% cream: thin layer twice daily for 2 weeks

Reassess if not improving by course end; adapt the spoken duration for this indication.

Before prescribing

Confirm fungal diagnosis and site; review allergy and pregnancy. This is plain skin cream, not clotrimazole/betamethasone, an oral troche or a vaginal product.

Side effects and return precautions

Local stinging, redness or irritation; stop and reassess significant reaction or worsening rash.

Follow-up

Review failure to improve within 2 weeks for jock itch or 4 weeks for ringworm/athlete’s foot. Reconsider diagnosis and need for another treatment.

Sources

Checked September 24, 2026.

Colchicine (Colcrys)Acute gout flare

What to say

For this gout attack, take 1.2 milligrams now, then 0.6 milligrams one hour later. With 0.6-milligram tablets, that’s two tablets followed by one. That’s the full starting course for this attack. Taking extra doesn’t improve relief and can be dangerous.

Mild diarrhea, nausea or cramps can happen. For severe or persistent diarrhea, vomiting or significant belly pain, stop colchicine and get same-day medical care. If you can’t keep fluids down or feel very ill, go to the emergency department. Don’t keep repeating that starting course. Contact us if the pain isn’t controlled. Check with us before any new prescription, especially antibiotics or antifungals, because some combinations can cause dangerous side effects. For marked muscle weakness or dark urine, stop colchicine and go to the emergency department. A fever with a hot swollen joint needs same-day assessment because it may be an infection rather than gout. If you feel very ill, go to the emergency department.

Clinical reference

Dose options

Acute gout flare

1.2 mg orally at the first sign, then 0.6 mg one hour later; maximum 1.8 mg over one hour

Low-dose course. Higher loading doses are not more effective. Persistent symptoms require a plan, not repeated hourly tablets.

Renal / hepatic / interaction limits

Severe renal or hepatic impairment: do not repeat a flare course more often than every 2 weeks; dialysis flare dose 0.6 mg once

Treatment during existing prophylaxis in renal/hepatic impairment is generally not recommended by label. Strong CYP3A4/P-gp inhibitors plus renal or hepatic impairment are contraindicated.

Before prescribing

Confirm gout versus septic arthritis, renal/hepatic function, current prophylaxis and all interactions. Clarithromycin, ritonavir/cobicistat, cyclosporine and other inhibitors may cause fatal toxicity. Review statins and myopathy risk.

Side effects and return precautions

GI toxicity can precede serious poisoning; marrow suppression, neuromyopathy and rhabdomyolysis. Suspected overdose needs immediate emergency/poison-control advice, even before symptoms develop.

Follow-up

Reassess uncontrolled pain, severe GI effects or an atypical febrile joint promptly. Set a separate plan for ongoing flare treatment and long-term urate lowering.

Sources

Checked September 22, 2026.

Colchicine (Colcrys)Gout flare prevention

What to say

While we start or adjust your uric-acid treatment, take colchicine 0.6 milligrams once daily to help prevent gout attacks. This is the prevention schedule, even on days without pain. It doesn’t lower uric acid itself. We’ll review the need after three to six months, and continue longer if attacks are still occurring. If a flare happens, contact us for the treatment plan rather than adding the flare doses yourself.

Diarrhea or nausea can happen. Stop it and get same-day advice for persistent vomiting, diarrhea or significant belly pain. Marked muscle weakness or dark urine needs emergency assessment. Check before starting any antibiotic, antifungal or other new medicine: some combinations can be dangerous. Don’t take extra tablets for a missed dose.

Clinical reference

Dose options

Gout prophylaxis

0.6 mg once or twice daily; maximum 1.2 mg/day

Separate purpose and schedule. With severe renal impairment, prophylaxis often starts 0.3 mg/day; dialysis 0.3 mg twice weekly under the label.

Before prescribing

Review kidney/liver function, preventive dose and all interactions. Strong CYP3A4/P-gp inhibitors with renal or hepatic impairment are contraindicated. Check statins and myopathy risk; do not automatically add flare treatment to prophylaxis, especially with organ impairment.

Side effects and return precautions

GI toxicity can precede serious poisoning; marrow suppression, neuromyopathy and rhabdomyolysis. Suspected overdose needs immediate emergency/poison-control advice, even before symptoms develop.

Follow-up

Review tolerance, renal/hepatic function and interactions. ACR recommends prophylaxis for at least 3–6 months when starting urate-lowering therapy, with reassessment and continuation for ongoing flares.

Sources

Checked September 22, 2026.

Cyanocobalamin (vitamin B12)Vitamin B12 deficiency

What to say

Low vitamin B12 can cause anemia, tiredness, and numbness or tingling. Take 1,000 micrograms of vitamin B12 by mouth once a day, every day; an over-the-counter cyanocobalamin tablet works. If your body can’t absorb B12, as with pernicious anemia or after some stomach or bowel surgery, or if nerve symptoms are severe, we’ll use shots instead: several over the first 2 to 3 weeks, then monthly, often for life.

B12 is very safe; shots rarely cause itching, a rash or mild diarrhea. You may feel better within a few weeks, but nerve symptoms can take months to improve and may not fully recover. Don’t take folic acid instead of B12. If metformin or an acid reducer caused the low level, keep taking B12 while you’re on that medicine. Call us if numbness, weakness, balance or memory get worse. Trouble breathing or face swelling after a shot means call 911.

Clinical reference

Dose options

Oral replacement

1,000–2,000 mcg orally once daily

As effective as IM for anemia and neurologic symptoms when taken daily (AAFP, Cochrane). NICE: ≥1 mg/day if malabsorption is possible; suits dietary, medicine-related or uncertain causes.

IM loading (severe deficiency, neurologic signs, malabsorption)

1,000 mcg IM 3 times weekly for 2 weeks (every other day for up to 3 weeks if neurologic signs), then monthly

BSH schedules cited by AAFP. The U.S. label uses 100 mcg doses: daily for 6–7 days, alternate days for 7 doses, every 3–4 days for 2–3 weeks, then 100 mcg monthly for life. Avoid IV use.

Lifelong injections

Autoimmune gastritis (pernicious anemia), total gastrectomy or terminal ileal resection

NICE 2024 and the U.S. label (oral “not dependable”) favor lifelong IM; AAFP reports high-dose oral as effective as IM, so reserve oral for reliable daily adherence with follow-up. Reversible causes: treat until corrected and symptoms resolve.

Before prescribing

Confirm deficiency (B12, MMA if equivocal); check CBC, folate and iron; identify the cause (autoimmune gastritis, GI surgery, metformin/PPI, diet, nitrous oxide). Cobalt/B12 allergy, Leber optic atrophy. Replace B12 before folate.

Side effects and return precautions

Severe megaloblastic anemia: check potassium in the first 48 h (hypokalemia and sudden death reported). Rare anaphylaxis, early heart failure, unmasked polycythemia vera. Folic acid alone can mask deficiency.

Follow-up

Review at about 3 months, sooner if severe; anemia corrects by about 8 weeks, neurologic symptoms over months. Don’t retest B12 on IM therapy (NICE). Autoimmune gastritis: endoscopy for new upper GI symptoms.

Sources

Checked October 15, 2026.

Cyclobenzaprine IR (Flexeril)Acute muscle spasm

What to say

For this short episode of painful muscle spasm, try cyclobenzaprine 5 milligrams up to three times a day as needed for the next few days. Try the first dose in the evening when you won’t need to drive. Use it alongside gentle movement and the activity plan we discussed. It can ease spasm, but it won’t repair the underlying strain.

Sleepiness, dry mouth, constipation, or dizziness can happen. Don’t drink alcohol or combine it with sleep medicines or other sedatives without checking. Don’t drive while affected. Stop it and go to the emergency department for a new racing or irregular heartbeat. Chest pain or fainting means call 911. Stop and go to the emergency department for fever with confusion, sweating, shaking or stiff muscles, especially with antidepressants. Go to the emergency department if you can’t pass urine. We’ll reassess within a week if you still need it. Don’t continue beyond two to three weeks without a new evaluation.

Clinical reference

Dose options

Acute muscle spasm, immediate release

5 mg orally three times daily; the wording above uses doses only when needed

Adjunct to rest/physical therapy for acute painful musculoskeletal spasm. Lowest effective dose for a brief course; not a chronic spasticity treatment.

Upper dose / duration

May increase to 10 mg three times daily; no longer than 2–3 weeks

Escalate only after review of benefit and sedation. This does not apply to once-daily extended-release capsules.

Older adults / liver disease

Generally avoid in older adults; if used, start 5 mg and consider less frequent dosing

Mild hepatic impairment: start 5 mg cautiously; moderate/severe hepatic impairment: not recommended. No validated renal dosing algorithm in label.

Before prescribing

Check sedatives and serotonergic drugs, including SSRIs/SNRIs/tramadol. Contraindicated with MAOIs or within 14 days, acute MI recovery, arrhythmias/conduction disorders, heart failure and hyperthyroidism. Review urinary retention/glaucoma and fall risk.

Side effects and return precautions

Sedation and anticholinergic effects are common. Palpitations, retention or major confusion need prompt assessment; serotonin-syndrome features, syncope or chest pain need emergency care. Reassess new neurologic red flags rather than escalating a muscle relaxant.

Follow-up

Review within about a week if continued need or poor improvement. Stop when spasm settles; reassess diagnosis/function if symptoms persist. Avoid automatic refills or extending treatment beyond 2–3 weeks.

Sources

Checked September 20, 2026.

Dapagliflozin (Farxiga)Heart failure and chronic kidney disease

What to say

I’m starting dapagliflozin 10 milligrams once a day to lower your risk of a heart-failure hospital stay and to protect your kidneys. It helps even without diabetes, and a higher dose isn’t needed. Take it with or without food, and don’t double up after a missed dose. You may pee more at first. A small early dip in your kidney blood test is expected.

Genital yeast infections can happen; call us about itching, discharge or burning when you pee. If you’re sick and can’t eat or drink normally, pause it and call us about restarting. Stop it at least 3 days before surgery or a procedure that needs fasting. For vomiting, belly pain, unusual tiredness or fast breathing, stop it and go to the emergency department, even if your sugar is normal. Genital or groin pain or swelling with fever needs emergency care too. If you take insulin, don’t stop it on your own.

Clinical reference

Dose options

Heart failure (any EF) or CKD at risk of progression

10 mg orally once daily, with or without food

No titration. Label: don’t start at eGFR <25, but may continue if eGFR later falls below 25. KDIGO 2024 supports starting at eGFR ≥20 and continuing until dialysis.

Type 2 diabetes glycemic dosing

5 mg once daily, may increase to 10 mg

Not recommended for glycemic control at eGFR <45; use 10 mg for the HF and CKD indications.

Surgery and acute illness

Withhold ≥3 days before surgery or procedures with prolonged fasting; hold during illness with poor intake

Resume when clinically stable and eating and drinking.

Before prescribing

Check eGFR, volume status and diuretic dose. Review insulin or sulfonylurea, prior ketoacidosis, ketogenic diet, heavy alcohol use, genitourinary infections, lithium and pregnancy. Not for type 1 diabetes, polycystic kidney disease or recent kidney immunosuppression.

Side effects and return precautions

Genital mycotic infection, UTI/urosepsis, volume depletion, hypotension and AKI, especially with loop diuretics or older age. Ketoacidosis can occur with near-normal glucose; Fournier gangrene is rare but urgent.

Follow-up

Monitor eGFR and volume as indicated, sooner with loop diuretics or frailty; the early reversible eGFR dip isn’t a reason to stop. Review HF symptoms, weight, diuretic needs and albuminuria.

Sources

Checked October 15, 2026.

Denosumab (Prolia)Osteoporosis

What to say

Denosumab lowers your chance of breaking a bone. It’s a 60 milligram shot under the skin, given here every 6 months, with the next one on [date]. Take the calcium and vitamin D we recommend every day. Most important: don’t skip or delay a dose. Its effect wears off quickly, and stopping without a plan can cause fast bone loss and several spine fractures. If we ever stop it, we’ll switch you to another bone medicine, usually a bisphosphonate.

Back, joint or muscle pain and skin rashes can happen. Red, hot, swollen skin or a fever needs same-day care. Muscle cramps, twitching, or tingling around your mouth or fingers can mean low calcium: call us the same day, or 911 for a seizure. Tell your dentist you take it, and tell us about jaw pain or a mouth sore that won’t heal. New thigh or groin pain needs a check. Don’t combine it with Xgeva or another denosumab product.

Clinical reference

Dose options

Osteoporosis treatment

60 mg SC every 6 months, given by a clinician

With calcium 1,000 mg and vitamin D ≥400 IU daily per label. Missed dose: give as soon as possible, then every 6 months from that date. Biosimilars (e.g., Jubbonti) use the same schedule.

Stopping

Don’t stop or delay without a follow-on antiresorptive, usually a bisphosphonate

Turnover rebounds above baseline by 9 months after the last dose; vertebral fractures reported from 7 months. No drug holiday (Endocrine Society).

eGFR <30 or dialysis

No dose change, but assess CKD-MBD first (iPTH, calcium, 25(OH)D, 1,25(OH)2D)

Boxed warning: severe hypocalcemia. Supervise with CKD-MBD expertise; calcium weekly for the first month, then monthly.

Before prescribing

Correct hypocalcemia and vitamin D deficiency first. Check calcium, eGFR and pregnancy (contraception during and ≥5 months after). Do an oral exam; dental review if ONJ risk. Plan the exit strategy before the first dose.

Side effects and return precautions

Hypocalcemia (check calcium, phosphorus and magnesium 10–14 days after a dose if predisposed), cellulitis and serious infections, dermatitis, severe musculoskeletal pain, ONJ, atypical femur fracture, hypersensitivity.

Follow-up

Track injection dates with recalls before each 6-month due date. Repeat DXA per plan. Reassess fracture risk at 5–10 years; if stopping, transition to a bisphosphonate without a gap.

Sources

Checked October 15, 2026.

Desvenlafaxine (Pristiq)Depression

What to say

For depression, take desvenlafaxine 50 milligrams once a day, with or without food. That’s both the starting and the usual dose. Swallow it whole; don’t split, crush or chew it. An empty tablet shell may appear in your stool; that’s normal. Benefits build over several weeks.

Nausea, dizziness, sweating, poor sleep or sexual side effects can happen. It can raise blood pressure, so we’ll check yours. Avoid alcohol. Missing doses or stopping suddenly can cause dizziness, irritability or electric-shock feelings, so refill on time. Call the same day for worsening thoughts of self-harm, marked agitation or unusually high energy with very little sleep. If you might act on those thoughts, call 911; 988 can provide crisis support. Go to the emergency department for fever with confusion, shaking or stiff muscles. Check with us before adding mood or migraine medicines, tramadol, blood thinners or daily ibuprofen.

Clinical reference

Dose options

Adult depression

50 mg orally once daily, with or without food; no titration

Trials of 50–400 mg/day showed no added benefit above 50 mg and more adverse effects; VA/DoD lists 100 mg/day as the maximum. Swallow whole.

Renal or hepatic impairment

CrCl 30–50: maximum 50 mg/day. CrCl <30 or ESRD: 25 mg daily or 50 mg every other day; no supplemental dose after dialysis

Child-Pugh 7–15: 50 mg/day; don’t exceed 100 mg/day. Older adults: allow for lower renal clearance; orthostatic hypotension was more frequent at ≥65.

Stopping or switching

Taper gradually, using the 25 mg tablet; some patients need several months

If symptoms are intolerable, resume the prior dose and taper more slowly. Switching from venlafaxine can cause discontinuation symptoms. MAOIs: 14 days before starting; 7 days after stopping.

  • Venlafaxine’s active metabolite; generic. Fixed 50 mg dose without titration, and its own levels don’t depend on CYP2D6. Labeled only for MDD; venlafaxine XR and duloxetine also cover anxiety, and duloxetine pain.

Before prescribing

Check BP (control hypertension first) and CrCl. Screen suicidality, bipolar/mania history, seizures, narrow angles, sodium and bleeding risk, pregnancy plans. Contraindicated: venlafaxine/desvenlafaxine hypersensitivity, MAOIs (14 days before, 7 after), linezolid, IV methylene blue. Drugs mainly cleared by CYP2D6 (metoprolol, atomoxetine) may rise; tamoxifen needs no change.

Side effects and return precautions

Nausea, dizziness, insomnia, sweating, sexual dysfunction. Sustained BP rise (reduce or stop), orthostasis in older adults, lipid rises (mostly at high doses), hyponatremia, bleeding, serotonin syndrome, seizures, mania, ILD/eosinophilic pneumonia. False-positive PCP/amphetamine urine screens.

Follow-up

Review with BP within 2 weeks (1 week if 18–25 or higher suicide risk); recheck BP periodically. Judge response over 6–12 weeks; continue ≥6 months after remission; taper slowly.

Sources

Checked October 21, 2026.

Dextromethorphan/bupropion ER (Auvelity)Depression

What to say

We’re using Auvelity for depression. It combines dextromethorphan, found in some cough medicines, with bupropion (Wellbutrin), which keeps more dextromethorphan in your body. Take 1 tablet each morning for 3 days. From day 4, take 1 tablet twice a day, at least 8 hours apart. Swallow it whole. If you miss a dose, skip it. Benefit builds over several weeks.

Dizziness, headache, diarrhea and sleepiness are common. Don’t drive until you know how it affects you. Bupropion can cause seizures: never take extra. Limit alcohol, but don’t suddenly stop heavy drinking, sedatives or seizure medicines on your own. Don’t add other bupropion (Wellbutrin, Zyban, Contrave) or dextromethorphan cough medicines, like Delsym or “DM” products. It isn’t recommended during pregnancy or breastfeeding. Call the same day for worsening mood, thoughts of self-harm, or very high energy with little sleep. If you might act on those thoughts or have a seizure, call 911; 988 offers crisis support.

Clinical reference

Dose options

Adult MDD (45 mg/105 mg ER tablet)

1 tablet each morning for 3 days; from day 4, 1 tablet twice daily ≥8 hours apart; maximum 2 tablets/day

Swallow whole, with or without food; skip a missed dose. Bupropion totals 210 mg/day, but seizure risk is dose-related, so added bupropion from any product raises it.

Once-daily maximum

1 tablet each morning only with eGFR 30–59, strong CYP2D6 inhibitors (e.g., paroxetine, fluoxetine, quinidine, terbinafine) or known CYP2D6 poor metabolizers

Not recommended: eGFR 15–29 (not studied) or Child-Pugh C; no change for Child-Pugh A–B. Avoid strong CYP2B6 inducers (e.g., carbamazepine).

Interactions and other strength

≥14 days between an MAOI and Auvelity either way; don’t start during linezolid or IV methylene blue

Bupropion inhibits CYP2D6: narrow-index substrates (e.g., TCAs) may need lower doses; prodrugs such as tamoxifen may work less well; monitor digoxin levels. The 30 mg/105 mg tablet is only for the Alzheimer’s-agitation titration added April 2026.

  • Differs from bupropion XL or SR: less bupropion (210 mg/day), which also blocks CYP2D6 to raise dextromethorphan levels; avoid adding Wellbutrin, Zyban, Contrave or OTC dextromethorphan. CANMAT 2023: second line (limited evidence). Brand-only; no FDA-approved generic.

Before prescribing

Boxed warning: suicidality in young adults. Check BP; screen for bipolar history, MAOIs and duplicate bupropion (Wellbutrin, Zyban, Contrave) or dextromethorphan (OTC cough products, Nuedexta). Contraindicated: seizure disorder, bulimia/anorexia, abrupt alcohol/benzodiazepine/barbiturate/antiepileptic withdrawal. Check eGFR, narrow angles, pregnancy, breastfeeding.

Side effects and return precautions

Dizziness (14% vs 6% placebo) and falls, headache, diarrhea, somnolence, dry mouth, sexual dysfunction, sweating. Seizure (stop; don’t restart), hypertension, mania, psychosis, serotonin syndrome with SSRIs/TCAs, hyponatremia, angle closure, misuse.

Follow-up

Early check of mood, suicidality and BP, then BP periodically; consider sodium if ≥60 or on diuretics. Track a symptom scale every 2–4 weeks; if <20% improvement by 4 weeks, consider switching (CANMAT).

Sources

Checked October 21, 2026.

Diclofenac 1% gel (Voltaren Arthritis Pain)Hand osteoarthritis

What to say

For arthritis pain in this hand, measure 2 grams of diclofenac 1% gel with the dosing card and apply it four times daily to the affected area. Don’t use more than 8 grams on this hand in a day. Wait at least an hour before washing the treated hand. It helps pain but doesn’t reverse arthritis.

Use it only on intact skin and avoid heating pads or tight coverings. Don’t add oral ibuprofen, naproxen or another anti-inflammatory without checking. Stop for significant skin irritation. Black stools, vomiting blood, chest pressure or severe breathing trouble needs urgent or emergency care. We’ll reassess pain and hand function after a short trial.

Clinical reference

Dose options

Hand/wrist/elbow osteoarthritis, 1% gel

2 g per affected joint four times daily; maximum 8 g/day per upper-extremity joint

Across all treated joints, maximum 32 g/day. Wait at least one hour before washing a treated hand.

Product/skin limits

Use the supplied dosing card; no heat or occlusive dressing

Not the dosing for 2% solution, 3% actinic-keratosis gel or patches. Avoid broken skin; wait ≥1 hour before bathing.

Before prescribing

Review NSAID hypersensitivity, GI bleed, kidney/CV disease, anticoagulants and pregnancy. Avoid NSAIDs from 20 weeks unless specifically necessary; avoid at ≥30 weeks. Consider systemic exposure despite topical route.

Side effects and return precautions

Local dermatitis; serious NSAID bleeding, renal and cardiovascular effects remain possible. Avoid routine combination with oral NSAIDs.

Follow-up

Review pain and hand function within 1–3 weeks. If using the OTC product, do not continue beyond 21 days without clinician direction; check renal/BP and bleeding risk if treatment continues.

Sources

Checked September 23, 2026.

Diclofenac 1% gel (Voltaren Arthritis Pain)Knee osteoarthritis

What to say

For the osteoarthritis pain in this knee, apply diclofenac 1% gel four times a day. Measure 4 grams with the dosing card each time, then spread it over the knee. That’s no more than 16 grams on this knee in a day. Use it on intact skin and wash your hands afterward.

Wait at least an hour before bathing, and don’t use a heating pad or tight dressing over it. Skin irritation can happen. Stop and contact us for a rash. Check before combining it with ibuprofen, naproxen or another anti-inflammatory medicine. Less medicine reaches the bloodstream than with tablets, but stomach, kidney and heart risks still matter. Stop and go to the emergency department for black stools or vomiting blood. Chest pain or severe breathing trouble means call 911. We’ll review pain and walking in two weeks before continuing.

Clinical reference

Dose options

Knee/ankle/foot osteoarthritis

1% gel: 4 g per affected joint four times daily

Maximum 16 g/day per lower-extremity joint.

Product/skin limits

Use the supplied dosing card; no heat or occlusive dressing

Not the dosing for 2% solution, 3% actinic-keratosis gel or patches. Avoid broken skin; wait ≥1 hour before bathing.

Before prescribing

Review NSAID hypersensitivity, GI bleed, kidney/CV disease, anticoagulants and pregnancy. Avoid NSAIDs from 20 weeks unless specifically necessary; avoid at ≥30 weeks. Consider systemic exposure despite topical route.

Side effects and return precautions

Local dermatitis; serious NSAID bleeding, renal and cardiovascular effects remain possible. Avoid routine combination with oral NSAIDs.

Follow-up

Review function and tolerability at about two weeks; continue only if useful. Monitor BP/renal function when exposure, comorbidity or duration warrants it.

Sources

Checked September 23, 2026.

Dicyclomine (Bentyl)IBS cramps

What to say

Dicyclomine relaxes the bowel muscle to ease IBS cramping. Take [10 or 20] milligrams up to 4 times a day when cramping flares, with or without food. It eases cramps, not diarrhea or constipation. If it isn’t clearly helping within 2 weeks, stop it and tell us. Take antacids at a different time, because they can block its absorption.

Dry mouth, dizziness, blurred vision, sleepiness and constipation are common. Don’t drive until you know how it affects you. It reduces sweating, so avoid overheating in hot weather or hard exercise. Stop it and call us the same day if you can’t pass urine or have a swollen, very painful belly, a racing heartbeat or new confusion. Sudden eye pain with blurred vision means stop it and get emergency eye care. Avoid other drying medicines such as diphenhydramine. Call us for rectal bleeding, weight loss or fever, which aren’t typical of IBS.

Clinical reference

Dose options

IBS cramping, as used here

10–20 mg orally up to 4 times daily as needed

Label: start 20 mg four times daily, may increase to 40 mg four times daily after 1 week; stop if no benefit within 2 weeks or if side effects keep the dose below 80 mg/day.

Older adults

Avoid if possible (AGS Beers 2023: strongly anticholinergic, uncertain effectiveness)

If used, choose the lowest dose for short periods and review total anticholinergic burden.

  • Label–guideline difference: ACG 2021 recommends against US-available antispasmodics for global IBS symptoms (conditional, low quality); AGA 2022 suggests antispasmodics. Reserve for intermittent cramping.

Before prescribing

Confirm IBS without alarm features. Contraindicated: glaucoma, obstructive uropathy, GI obstruction, severe ulcerative colitis, reflux esophagitis, myasthenia gravis, unstable cardiovascular status in acute hemorrhage, breastfeeding. Review age and anticholinergic burden.

Side effects and return precautions

Dizziness, dry mouth, blurred vision, nausea, somnolence; urinary retention, constipation or ileus, tachycardia, heat prostration, angle closure and delirium in older adults (usually clears 12–24 hours after stopping).

Follow-up

Review benefit at 2 weeks and stop if unclear. Use a pain/stool diary and keep first-line measures (soluble fiber, diet, gut-brain therapies) rather than escalating the dose.

Sources

Checked October 15, 2026.

Diltiazem ER (Cardizem CD)Atrial fibrillation rate control, off-label

What to say

For atrial fibrillation, diltiazem keeps your heart from racing. This use of the long-acting capsule is off-label, but heart guidelines support it. Take [dose] once a day, with or without food, and swallow it whole. Avoid alcohol, which can make this capsule release the medicine too fast. If you miss a dose, take it when you remember unless the next one is close; never double up. It controls your heart rate but doesn’t replace a blood thinner.

Ankle swelling, constipation, headache and dizziness can happen. Check your pulse as we showed you, and call us the same day if it’s outside the limits we write down or you feel lightheaded. Fainting, severe shortness of breath or chest pain that doesn’t go away means call 911. Diltiazem raises levels of many medicines, including some statins and blood thinners, so check with us before starting anything new. Don’t stop it on your own, because your heart rate can climb again.

Clinical reference

Dose options

Long-term oral rate control

Diltiazem ER 120–360 mg once daily, titrated to resting heart rate and symptoms

2023 guideline dosing table; the Cardizem CD label covers hypertension and angina only, with limited experience above 360 mg. Start low in older adults.

Formulation

Cardizem CD capsule once daily; switch from other diltiazem products at the nearest equivalent total daily dose, then retitrate

Diltiazem ER products (e.g., Cardizem CD, Cardizem LA, Tiazac) have different release profiles; keep one product. The label advises avoiding alcohol with Cardizem CD because alcohol speeds drug release in vitro.

Statin limits with diltiazem

Simvastatin ≤10 mg/day (with diltiazem ≤240 mg/day); lovastatin ≤20 mg/day

Prefer a statin not metabolized by CYP3A4, such as pravastatin or rosuvastatin.

  • Off-label: oral diltiazem ER is FDA-labeled for hypertension and angina; the 2023 AF guideline gives beta-blockers or diltiazem/verapamil a Class 1 recommendation for long-term rate control.

Before prescribing

Check LVEF and BP. Avoid with LVEF <40% or decompensated HF, pre-excited AF/WPW, SBP <90, or sick sinus/2nd–3rd-degree AV block without a pacemaker. Review CYP3A4/P-gp interactions (statins, DOACs, cyclosporine, digoxin, ivabradine, rifampin), beta-blockers and clonidine.

Side effects and return precautions

Edema, constipation, headache and dizziness; bradycardia, AV block, hypotension and worsening HF, especially with beta-blockers or digoxin. Transaminase elevation and rash, rarely SJS/TEN, need prompt review.

Follow-up

Review resting and exertional HR, symptoms, BP and ECG after each change. Target resting HR generally <100–110, guided by symptoms. Manage anticoagulation separately.

Sources

Checked October 15, 2026.

Donepezil (Aricept)Alzheimer disease

What to say

Donepezil can modestly help memory, thinking and daily function in Alzheimer disease for a time, but it doesn’t stop the disease from progressing. Take 5 milligrams once a day at bedtime, with or without food. If it’s well tolerated, we’ll increase to 10 milligrams after four to six weeks. If it causes vivid dreams or poor sleep, take it in the morning instead. If you miss a dose, skip it; if you’ve missed more than a week, call us before restarting.

Nausea, diarrhea, poor appetite, muscle cramps and tiredness are common at first and often settle within a few weeks. Call us for weight loss, ongoing vomiting, dizziness, fainting or a very slow pulse. Black or bloody stools or vomiting blood means go to the emergency department, especially if you take anti-inflammatory pain relievers. Some allergy, bladder and sleep medicines work against it, so check with us first. What family members notice helps us judge whether it’s working.

Clinical reference

Dose options

Mild to moderate Alzheimer disease

5 mg once daily at bedtime; after 4–6 weeks may increase to 10 mg once daily

The label specifies evening dosing; NHS advice allows morning dosing for insomnia or vivid dreams. ODT dissolves on the tongue, followed by water.

Moderate to severe Alzheimer disease

23 mg once daily only after ≥3 months on 10 mg

More nausea, vomiting, weight loss and GI bleeding than 10 mg; swallow 23 mg whole. Clearance unchanged in renal impairment and about 20% lower in stable cirrhosis.

Before prescribing

Confirm Alzheimer dementia (MCI is not a labeled use) and caregiver support. Check pulse, conduction disease, syncope, rate-slowing drugs, ulcer/GI bleeding risk, NSAIDs, asthma/COPD, seizures, bladder outflow obstruction, weight, anticholinergics and planned anesthesia (succinylcholine).

Side effects and return precautions

GI effects, anorexia and weight loss, insomnia or abnormal dreams, muscle cramps; bradycardia, heart block, syncope and falls; GI bleeding; urinary retention; seizures; bronchospasm. Postmarketing QT prolongation/torsades, NMS and rhabdomyolysis are rare.

Follow-up

Review tolerance before each increase and benefit with the patient and caregiver periodically; effects may wane. NICE: don’t stop for disease severity alone. After a gap over 1 week, consider re-titrating from 5 mg.

Sources

Checked October 15, 2026.

Doxepin 3–6 mg (Silenor)Insomnia with night waking

What to say

For waking up during the night, we’re adding low-dose doxepin to your sleep plan, which includes cognitive behavioral therapy for insomnia. Take [3 or 6] milligrams within 30 minutes of bedtime, only when you can get a full night’s sleep. Don’t take it within 3 hours of a meal; food can delay its effect and leave you groggy the next morning.

Next-day drowsiness and nausea can happen. Don’t drive or do anything risky if you feel sleepy, and don’t drink alcohol with it. Check with us before adding other sedating medicines or cimetidine (Tagamet). If you sleepwalk, drive or do other things without being fully awake, stop it and call us. Call the same day for worsening depression or thoughts of self-harm. If you might act on those thoughts, call 911. Let us know if you’re still not sleeping better after 7 to 10 days.

Clinical reference

Dose options

Sleep-maintenance insomnia

6 mg within 30 minutes of bedtime (3 mg may suffice); age ≥65: start 3 mg, may increase to 6 mg

Maximum 6 mg/day; not within 3 hours of a meal. AASM 2017 (weak) supports doxepin for sleep maintenance; VA/DoD 2025 lists it among suggested agents when pharmacotherapy is offered, with CBT-I first-line.

Hepatic impairment, urinary retention tendency, cimetidine

Start 3 mg; with cimetidine, maximum 3 mg

Metabolized by CYP2C19 and CYP2D6; inhibitors raise exposure. Not ordinarily recommended in severe sleep apnea.

Formulation

Use the 3- or 6-mg tablet product

Antidepressant-strength doxepin isn’t interchangeable. Beers 2023: safety at ≤6 mg/day is comparable to placebo; avoid >6 mg/day in older adults.

Before prescribing

Confirm sleep-maintenance insomnia; evaluate sleep apnea, depression, substance use and medications, with CBT-I first. Contraindicated: MAOI within 2 weeks, untreated narrow-angle glaucoma, severe urinary retention. Review sedatives, alcohol, cimetidine and CYP2C19/2D6 inhibitors.

Side effects and return precautions

Somnolence, next-day impairment and nausea; complex sleep behaviors (stop); worsening depression or suicidal thinking.

Follow-up

Reevaluate if insomnia persists after 7–10 days. Review sleep diary, daytime function and sedation; continue CBT-I and use the shortest effective course.

Sources

Checked October 15, 2026.

Doxycycline (Vibramycin)Acne

What to say

For your inflamed acne, we’ll use doxycycline 100 milligrams once a day along with your prescribed topical treatment, including benzoyl peroxide. It takes several weeks to see improvement. We’ll review your skin in about three months and aim to stop the antibiotic once it’s no longer needed, while continuing the topical plan.

Take each dose with a full glass of water and stay upright for at least 30 minutes. Food can help nausea. Use sun protection and ask the pharmacist how to separate mineral supplements and antacids. Tell us before starting if pregnancy is possible or you use isotretinoin. Call for painful swallowing or severe diarrhea. A severe headache with vision changes needs immediate assessment.

Clinical reference

Dose options

Adult inflammatory acne

100 mg orally once daily; review after about 12 weeks

Use with benzoyl peroxide and appropriate topical maintenance therapy. Limit antibiotic duration; do not use as indefinite monotherapy.

Before prescribing

Review acne severity/scarring, pregnancy, tetracycline allergy, swallowing problems and interactions. Avoid concurrent oral isotretinoin because of intracranial hypertension risk. Severe or scarring acne may warrant dermatology care.

Side effects and return precautions

GI upset, esophagitis, photosensitivity and candidiasis. Stop and seek emergency care for severe allergy or blistering/mucosal rash.

Follow-up

Review response, tolerability and adherence at approximately 12 weeks; seek earlier review for worsening or scarring. Continue non-antibiotic maintenance after stopping.

Sources

Checked September 23, 2026.

Doxycycline (Vibramycin)Bacterial sinusitis

What to say

For this bacterial sinus infection, I’m prescribing doxycycline 100 milligrams twice a day for [five / seven] days. Take each dose with a full glass of water and stay upright for at least 30 minutes. Taking it just before lying down can injure the food pipe.

Nausea and sun sensitivity can happen, so use sun protection. Ask the pharmacist how far to separate your particular iron, calcium, magnesium, antacids or multivitamins. Tell us if pregnancy is possible. For painful swallowing, a new rash or severe diarrhea, call the same day. Get advice before another dose if swallowing hurts. Stop it and go to the emergency department for a blistering or peeling rash, or a rash with mouth sores. Also call if the infection is worsening or not improving after three to five days. Trouble breathing or tongue swelling means stop it and call 911.

Clinical reference

Dose options

Adult bacterial sinusitis

100 mg orally twice daily for 5–7 days

Alternative when clinically appropriate; choose duration and antibiotic based on the infection.

Renal function

No routine renal adjustment

Confirm product, hepatic context and interacting medicines.

Before prescribing

Confirm indication, tetracycline allergy, pregnancy, swallowing problems and interacting minerals/retinoids. Pregnancy generally calls for another sinusitis antibiotic; exceptional infections have different risk-benefit decisions.

Side effects and return precautions

GI upset, esophagitis and photosensitivity. For severe headache with visual change, stop and obtain immediate assessment; severe allergic reaction is an emergency. Give product-specific mineral spacing.

Follow-up

For sinusitis, reassess worsening or no improvement after 3–5 days. Other infection and prevention courses have separate entries and follow-up plans.

Sources

Checked September 23, 2026.

Doxycycline (Vibramycin)Bacterial STI prevention (doxy-PEP), off-label

What to say

Based on your history and our discussion, doxy-PEP is an option to lower your risk of some bacterial STIs. Take doxycycline 200 milligrams as soon as possible after sex, within 72 hours. Don’t take more than 200 milligrams in any 24 hours, even after more than one encounter. This off-label use doesn’t prevent HIV and doesn’t replace testing or treatment of symptoms.

Take it with food and a full glass of water, and stay upright for an hour. Separate it by at least two hours from dairy, antacids and supplements containing calcium, iron or magnesium. Use sun protection. We’ll test for STIs at the relevant sites and review whether to continue every three to six months, alongside your HIV prevention or care plan.

Clinical reference

Dose options

CDC shared-decision population

200 mg once as soon as possible within 72 hours after oral, vaginal or anal sex; maximum 200 mg per 24 hours

CDC recommends discussing/offering to MSM and transgender women with syphilis, chlamydia or gonorrhea in the past 12 months. Evidence for other populations is insufficient for the same routine recommendation.

Before prescribing

Confirm eligibility and shared decision-making, tetracycline suitability and interacting drugs. Discuss GI/photosensitivity effects, antimicrobial resistance and microbiome uncertainty; arrange baseline site-specific STI and HIV testing and link to PrEP or HIV care.

Side effects and return precautions

GI upset, esophagitis and photosensitivity; severe headache/visual change or serious allergy needs urgent assessment. New STI symptoms need testing and treatment rather than extra prophylaxis doses.

Follow-up

At 3–6 months, repeat exposure-site STI testing, HIV testing per the applicable prevention/care plan, review adverse effects and reassess ongoing need. Do not add doses on top of another doxycycline course without review.

Sources

Checked September 23, 2026.

Doxycycline (Vibramycin)Chlamydia

What to say

Take doxycycline 100 milligrams twice a day for seven days to treat chlamydia. Take each dose with a full glass of water and stay upright for at least 30 minutes. Use sun protection, and ask the pharmacist how to separate it from antacids, iron and other mineral supplements. Tell us before starting if pregnancy is possible.

Avoid sex until you have finished the course, your symptoms have resolved, and your partners have completed treatment. We can help arrange partner care. We’ll repeat your chlamydia test in about three months because getting it again is common. Contact us promptly for pelvic or testicular pain, fever, painful swallowing, severe diarrhea or a new rash. Breathing trouble or tongue swelling means call 911.

Clinical reference

Dose options

Uncomplicated chlamydia, nonpregnant adult

100 mg orally twice daily for 7 days

This is treatment, not doxy PEP. PID, epididymitis and LGV need different regimens.

Before prescribing

Review pregnancy, allergy, interactions and infection sites; test for gonorrhea, HIV and syphilis. Arrange evaluation/treatment for partners from the previous 60 days, including the most recent partner if earlier.

Side effects and return precautions

GI upset, esophagitis and photosensitivity; severe headache with visual changes needs immediate assessment.

Follow-up

Retest at 3 months. Routine test of cure is unnecessary when nonpregnant unless adherence, symptoms or reinfection are concerns; avoid NAAT before 4 weeks after treatment.

Sources

Checked September 23, 2026.

Doxycycline (Vibramycin)Early Lyme disease (erythema migrans)

What to say

For the early Lyme disease rash we’ve diagnosed, take doxycycline 100 milligrams twice daily for ten days. Complete the prescribed course. This plan is for early skin disease. New neurologic or heart symptoms may require a different assessment and regimen.

Take it with a full glass of water and remain upright for at least an hour. Use sun protection. We’ll review how to separate it from antacids, iron, calcium and other minerals. Contact us for severe headache or vision changes, significant rash or severe diarrhea. Trouble breathing or tongue swelling means call 911. Contact us urgently for facial weakness, a severe headache with neck stiffness or new palpitations. Fainting, chest pain or severe breathlessness needs emergency care.

Clinical reference

Dose options

Adult erythema migrans

100 mg twice daily for 10 days

IDSA recommends 10 days; CDC lists 10–14 days and prefers the shorter effective course. Neurologic, cardiac and arthritis manifestations need separate plans.

Before prescribing

Assess exposure and rash, pregnancy, tetracycline allergy, swallowing risk, interactions and signs of disseminated disease. Do not delay appropriate treatment for a typical erythema migrans rash solely to await early serology.

Side effects and return precautions

Photosensitivity, GI upset and esophagitis; severe headache/visual change or serious allergic reaction needs urgent assessment. New cardiac or neurologic symptoms require reassessment of disease extent.

Follow-up

Review clinical response and new symptoms. Persistent nonspecific symptoms after adequate treatment do not automatically justify prolonged antibiotics.

Sources

Checked September 23, 2026.

Doxycycline (Vibramycin)Lyme prevention after a high-risk tick bite, off-label

What to say

This tick bite meets the criteria where a preventive dose may reduce Lyme disease risk. Take doxycycline 200 milligrams once, within 72 hours of removing the tick. This is an off-label, guideline-supported prevention plan, not a treatment course for an infection already causing symptoms.

Take it with a full glass of water and remain upright for at least an hour. Use sun protection. We’ll review how to separate it from antacids, iron, calcium and other minerals. Contact us for severe headache or vision changes, significant rash or severe diarrhea. Trouble breathing or tongue swelling means call 911. Prevention isn’t a guarantee and doesn’t prevent every tick-borne infection. Contact us if an expanding rash, fever or unexplained illness develops over the next month.

Clinical reference

Dose options

Eligible adult high-risk Ixodes bite

200 mg orally once within 72 hours of tick removal

IDSA high-risk criteria: identified Ixodes vector in a highly endemic area and attachment ≥36 hours. If the bite cannot be classified as high risk, observation is preferred; review doxycycline suitability and pregnancy individually.

Before prescribing

Document tick type, geography, estimated attachment duration and removal time. Confirm absence of current Lyme manifestations; review pregnancy, allergy and interactions. Do not give a multi-day Lyme-treatment course as routine prophylaxis.

Side effects and return precautions

GI upset, esophagitis and photosensitivity; serious allergy requires emergency care. New rash or systemic illness after prophylaxis needs reassessment.

Follow-up

Provide symptom monitoring for the next month; do not order routine Lyme serology in an asymptomatic person solely because of a tick bite.

Sources

Checked September 23, 2026.

Doxycycline (Vibramycin)Malaria prevention

What to say

For the malaria risk on your itinerary, take doxycycline 100 milligrams once daily. Start one to two days before entering the risk area, take it daily while there, and continue for four weeks after leaving. We’ll write the start and stop dates down. Keep using insect repellent, protective clothing and a bed net where appropriate.

Take it with a full glass of water and remain upright for at least an hour. Use sun protection. We’ll review how to separate it from antacids, iron, calcium and other minerals. Contact us for severe headache or vision changes, significant rash or severe diarrhea. Trouble breathing or tongue swelling means call 911. Fever during travel or after returning needs prompt medical assessment even if you took every dose. Tell the clinician where you traveled. This schedule prevents malaria and isn’t a treatment for fever that has already started.

Clinical reference

Dose options

Adult travel prophylaxis

100 mg orally once daily from 1–2 days before exposure through 4 weeks after leaving the malaria-risk area

Confirm current destination guidance. Not suitable during pregnancy; check breastfeeding circumstances and other contraindications. Take with adequate water and avoid lying down soon afterward.

Before prescribing

Review full itinerary, season, current country recommendations, pregnancy/breastfeeding, age, allergy, interactions, adherence and access to urgent care. Review live oral typhoid vaccine timing with the travel plan.

Side effects and return precautions

Photosensitivity, GI upset, esophagitis and candidiasis. No prophylaxis is fully protective; fever requires prompt malaria evaluation, not a self-directed higher doxycycline dose.

Follow-up

Document itinerary-specific dates, reinforce four weeks of post-travel doses and provide a fever/emergency plan. Reassess if the itinerary or pregnancy status changes.

Sources

Checked September 23, 2026.

Doxycycline (Vibramycin)Pneumonia

What to say

You have pneumonia, an infection in the lungs. Take doxycycline 100 milligrams twice a day for at least 5 days; we’ll tell you when it’s safe to stop. Take each dose with a full glass of water, and stay upright for 30 minutes. Take it at least 2 hours before or 3 hours after antacids, calcium, iron, magnesium, zinc or multivitamins.

Most people improve within 2 to 3 days; cough can last weeks. Nausea and easy sunburn can happen, so use sun protection. Call the same day for painful swallowing, severe watery diarrhea, a bad headache with vision changes, or if you aren’t improving after 3 days. Stop it and go to the emergency department for a blistering or peeling rash or mouth sores. Also go for worsening breathing or confusion. Call 911 for severe trouble breathing or face or tongue swelling. Tell us if you could be pregnant.

Clinical reference

Dose options

Outpatient CAP without comorbidities (ATS/IDSA 2019)

100 mg orally twice daily for ≥5 days and until clinically stable

Conditional recommendation, low-quality evidence; amoxicillin 1 g three times daily is the strongly recommended option. Label general adult dosing: 100 mg every 12 hours on day 1, then 100 mg daily, or 100 mg every 12 hours for more severe infections.

Outpatient CAP with comorbidities

Doxycycline 100 mg twice daily plus amoxicillin/clavulanate, cefpodoxime or cefuroxime

Conditional recommendation; doxycycline alone isn’t a guideline option when comorbidities are present. The label lists no renal dose adjustment.

Before prescribing

Confirm outpatient-appropriate CAP without comorbidities or MRSA/Pseudomonas risk factors (prior isolate, or hospitalization with IV antibiotics within 90 days). Check pregnancy, tetracycline allergy, esophageal problems, warfarin, isotretinoin and recent tetracycline use.

Side effects and return precautions

GI upset, pill esophagitis, photosensitivity and C. difficile; rare intracranial hypertension (headache, visual change) and SJS/TEN. Absorption falls with antacids, calcium, iron, magnesium and bismuth.

Follow-up

Contact at 48–72 hours. Stop after ≥5 days once stable. Not stable by day 5: assess for a resistant pathogen, complications or another diagnosis. No routine follow-up chest imaging if symptoms resolve.

Sources

Checked October 15, 2026.

Doxycycline (Vibramycin)Syphilis when penicillin is unavailable

What to say

With the penicillin shot in short supply, we’re treating your syphilis with doxycycline. Take 100 milligrams twice a day for 14 days if the infection is under a year old, or 28 days if it’s older or the timing is unknown. Missed doses can make treatment fail, so set reminders and tell us if you miss any. Take each dose with a full glass of water and stay upright for 30 minutes. Ask your pharmacist how to space it from antacids and minerals like iron. Tell us if you could be pregnant.

Use sun protection. Fever, chills or aches in the first day usually pass. Call the same day for painful swallowing, severe diarrhea, or a headache with blurred vision. Get urgent care for new vision or hearing changes or confusion. Avoid sex until sores or rash have healed and partners are treated. We’ll recheck your syphilis blood test at 6 and 12 months, or longer.

Clinical reference

Dose options

Primary, secondary or early latent syphilis (nonpregnant adult)

100 mg orally twice daily for 14 days

CDC 2021 alternative to benzathine penicillin G; CDC and SFDPH direct doxycycline for nonpregnant adults during the Bicillin L-A shortage. Label: 100 mg twice daily for 2 weeks when penicillin is contraindicated.

Late latent or unknown-duration syphilis

100 mg orally twice daily for 28 days

Label: 4 weeks for syphilis of more than 1 year’s duration. Efficacy in people with HIV is not well studied; follow closely.

Not appropriate for

Pregnancy, neurosyphilis, ocular syphilis or otosyphilis

Pregnancy: benzathine penicillin G only (desensitize if allergic). Neurologic, ocular or otic disease: IV aqueous penicillin G per CDC.

  • SFDPH (Apr 30, 2026): use doxycycline only when the patient can complete the multiday course; prioritize Bicillin L-A for people with doxycycline allergy.

Before prescribing

Stage the infection; screen for neurologic, ocular and otic symptoms. Exclude pregnancy. If adherence or follow-up is doubtful, prefer benzathine penicillin G or Lentocilin. Test HIV and other STIs; review cations, isotretinoin and warfarin.

Side effects and return precautions

Jarisch–Herxheimer reaction, pill esophagitis, photosensitivity, GI upset, C. difficile, intracranial hypertension (headache, visual change) and hypersensitivity.

Follow-up

Titers at 6 and 12 months (early) or 6, 12 and 24 months (late); closer with HIV. Sustained fourfold rise or inadequate decline: retreat with penicillin, evaluate HIV and CSF. Notify partners by stage.

Sources

Checked October 15, 2026.

Drospirenone (Slynd)Contraception, progestin-only pill

What to say

Slynd is a progestin-only birth control pill with no estrogen. Take 1 pill daily at about the same time: 24 white pills, then 4 green inactive pills, then start the next pack. Start on the first day of your period; if you start later, use condoms for 7 days. If you miss 1 white pill, take it when you remember and continue; no backup is needed.

If you miss 2 or more white pills in a row, take the most recent missed pill, continue, and use condoms until you’ve taken white pills 7 days in a row. If that happens in a pack’s first week and you had sex in the past 5 days, call us about emergency contraception. Irregular bleeding is common early. It can raise potassium, so tell us about kidney or adrenal problems or new blood pressure pills. Call 911 for chest pain or trouble breathing. Severe one-sided belly pain needs emergency care.

Clinical reference

Dose options

Daily regimen

Drospirenone 4 mg (white) days 1–24, inert (green) days 25–28; next pack the following day

Label: Day 1 start. CDC SPR 2024: start any time if reasonably certain not pregnant; backup 7 days if started >1 day after bleeding began.

Late or missed white pills (CDC SPR 2024)

1 late or missed (<48 hours): take ASAP, no backup. ≥2 consecutive (≥48 hours): take the last missed ASAP, continue; backup until 7 consecutive active days

Consider EC (not ulipristal) if missed in week 1 and unprotected sex in the prior 5 days. Label also advises 7-day backup after ≥2 missed.

Vomiting or diarrhea within 3 hours of a pill

Take another pill ASAP; if it lasts >24 hours, backup until 7 days after it resolves

CDC SPR 2024. Label wording uses 3–4 hours.

Before prescribing

Contraindicated with renal impairment, adrenal insufficiency, hepatic impairment or liver tumors, progestin-sensitive cancer, or undiagnosed abnormal bleeding. Check potassium before and in cycle 1 if on long-term potassium-raising drugs. Review CYP3A4 inducers.

Side effects and return precautions

Unscheduled bleeding (64% in cycle 1, 40% by cycle 13), acne, headache, weight gain. Watch for hyperkalemia, VTE, depression, and ectopic pregnancy with pelvic pain.

Follow-up

Review bleeding and adherence in 1–3 months; recheck potassium as above. Evaluate persistent abnormal bleeding; test for pregnancy after missed pills and absent bleeding.

Sources

Checked October 15, 2026.

Dulaglutide (Trulicity)Type 2 diabetes

What to say

For your type 2 diabetes, start Trulicity 0.75 milligrams once a week, on the same day, with or without food. If you have heart disease or several risk factors, it also lowers the chance of heart attack and stroke. Inject it under the skin of your belly, thigh or upper arm, holding the pen in place until the second click. After 4 weeks, we’ll review your readings before increasing. Take a missed dose only if your next one is at least 3 days away.

Nausea, fullness, diarrhea or constipation are common early; smaller meals help. Call the same day if you can’t keep fluids down. Severe belly pain that won’t go away, with or without vomiting, means stop it and go to the emergency department. If you use insulin or glipizide-type pills, we’ll lower that dose. Tell us about medullary thyroid cancer or MEN2, an inherited condition, in you or your family, vision changes, pregnancy plans or upcoming anesthesia.

Clinical reference

Dose options

Type 2 diabetes, including MACE reduction

0.75 mg SC weekly; after 4 weeks may increase to 1.5 mg; if more control is needed, 3 mg then 4.5 mg, each after ≥4 weeks on the prior dose

Maximum 4.5 mg weekly. REWIND (MACE reduction in established CVD or multiple risk factors) used 1.5 mg. Any time of day, with or without food.

Missed dose and changing the day

Give if ≥3 days (72 hours) remain before the next dose; otherwise skip

The weekly day can change if the last dose was ≥3 days earlier. With insulin, give separate injections; never mix.

Kidney, liver and storage

No dose adjustment for renal impairment, including ESRD

Use caution in ESRD and hepatic impairment; not recommended in severe gastroparesis. Refrigerate pens; each may stay ≤14 days at room temperature up to 86°F.

Before prescribing

Check MTC/MEN2, prior pancreatitis, severe gastroparesis, retinopathy and eye-exam status, pregnancy plans and other GLP-1 RA or DPP-4 inhibitor use (don’t combine). Plan sulfonylurea/insulin reduction. Monitor narrow-index oral drugs such as warfarin.

Side effects and return precautions

GI effects with dehydration and AKI; pancreatitis; gallbladder disease; retinopathy complications if prior retinopathy; hypoglycemia with insulin or sulfonylureas; anaphylaxis or angioedema. Tell anesthesia teams about use (aspiration risk).

Follow-up

Review tolerance and glucose before each step-up; A1c in about 3 months. ADA: when adding a GLP-1 RA, stop or reduce sulfonylureas and lower insulin (bolus 10–20%, basal ~10% if A1c <7.5%).

Sources

Checked October 15, 2026.

Duloxetine (Cymbalta)Chronic musculoskeletal pain

What to say

For chronic musculoskeletal pain, start duloxetine 30 milligrams once daily for one week, then 60 milligrams daily if tolerated. The goal is to reduce persistent muscle or joint pain and improve daily function. It works gradually and complements the activity and rehabilitation plan. It isn’t an as-needed painkiller. Swallow the capsule whole.

Nausea, dry mouth, constipation, sweating or sleep changes can happen early. Tell me if they’re troublesome. We’ll check blood pressure and arrange an early review. Stop it and contact us the same day for yellow eyes or skin. Call the same day for worsening thoughts of self-harm, marked agitation or unusually high energy with little sleep. If you can’t stay safe, call 911. For ordinary planned stopping, we’ll reduce the dose gradually to limit symptoms such as dizziness and nausea. Tell me about substantial alcohol use or liver disease.

Clinical reference

Dose options

Chronic musculoskeletal pain

30 mg orally once daily for one week, then 60 mg once daily

60 mg/day is the recommended target and maximum for this indication; higher doses have not shown added benefit and cause more adverse effects.

Organ function

Avoid with GFR <30 or chronic liver disease/cirrhosis

Review alcohol use, interactions and BP; taper planned discontinuation.

Before prescribing

Check indication, renal/liver disease, alcohol, BP, bipolar/suicide risk, serotonergic/MAOI and bleeding interactions. Discuss pregnancy and discontinuation rather than treating all indications identically.

Side effects and return precautions

GI, sweating, sleep and sexual effects; BP rise, hepatic injury, urinary retention, activation/suicidality and serotonin syndrome. Inability to pass urine needs immediate assessment.

Follow-up

Review tolerability, blood pressure, pain interference and function in 2–4 weeks. Reassess after a defined trial; taper if ineffective. Continue exercise/rehabilitation and other agreed non-drug treatment.

Sources

Checked September 23, 2026.

Duloxetine (Cymbalta)Depression

What to say

We’ll start duloxetine at 30 milligrams daily for a week, then increase to 60 milligrams if you’re tolerating it. The goal is improving your mood and ability to manage daily activities. Improvement builds over several weeks. Swallow the delayed-release capsule whole. Don’t open, crush or chew it. Food may help nausea.

Nausea, dry mouth, constipation, sweating or sleep changes can happen early. Tell me if they’re troublesome. We’ll check blood pressure and arrange an early review. Stop it and contact us the same day for yellow eyes or skin. Call the same day for worsening thoughts of self-harm, marked agitation or unusually high energy with little sleep. If you can’t stay safe, call 911. For ordinary planned stopping, we’ll reduce the dose gradually to limit symptoms such as dizziness and nausea. Tell me about substantial alcohol use or liver disease.

Clinical reference

Dose options

Depression

30 mg daily for one week, then 60 mg daily if tolerated

Usual target 60 mg/day; maximum 120 mg/day. Higher doses do not routinely add benefit. MDD labeled start is 40–60 mg/day; 30 mg for one week is a tolerability option.

Organ function

Avoid with GFR <30 or chronic liver disease/cirrhosis

Review alcohol use, interactions and BP; taper planned discontinuation.

Before prescribing

Check indication, renal/liver disease, alcohol, BP, bipolar/suicide risk, serotonergic/MAOI and bleeding interactions. Discuss pregnancy and discontinuation rather than treating all indications identically.

Side effects and return precautions

GI, sweating, sleep and sexual effects; BP rise, hepatic injury, urinary retention, activation/suicidality and serotonin syndrome. Inability to pass urine needs immediate assessment.

Follow-up

Early tolerability/safety and BP review; symptom/function reassessment over weeks. Use closer suicide-risk monitoring where indicated and gradual taper when stopping.

Sources

Checked September 22, 2026.

Duloxetine (Cymbalta)Diabetic nerve pain

What to say

We’ll start duloxetine at 30 milligrams daily for a week, then increase to 60 milligrams if you’re tolerating it. The goal is reducing the burning or shooting nerve pain from diabetes and helping you sleep and stay active. Improvement builds over several weeks. Swallow the delayed-release capsule whole. Don’t open, crush or chew it. Food may help nausea.

Nausea, dry mouth, constipation, sweating or sleep changes can happen early. Tell me if they’re troublesome. We’ll check blood pressure and arrange an early review. Stop it and contact us the same day for yellow eyes or skin. Call the same day for worsening thoughts of self-harm, marked agitation or unusually high energy with little sleep. If you can’t stay safe, call 911. For ordinary planned stopping, we’ll reduce the dose gradually to limit symptoms such as dizziness and nausea. Tell me about substantial alcohol use or liver disease.

Clinical reference

Dose options

Diabetic nerve pain

30 mg daily for one week, then 60 mg daily if tolerated

Lower tolerability start; recommended diabetic neuropathic pain dose and maximum 60 mg/day.

Organ function

Avoid with GFR <30 or chronic liver disease/cirrhosis

Review alcohol use, interactions and BP; taper planned discontinuation.

Before prescribing

Check indication, renal/liver disease, alcohol, BP, bipolar/suicide risk, serotonergic/MAOI and bleeding interactions. Discuss pregnancy and discontinuation rather than treating all indications identically.

Side effects and return precautions

GI, sweating, sleep and sexual effects; BP rise, hepatic injury, urinary retention, activation/suicidality and serotonin syndrome. Inability to pass urine needs immediate assessment.

Follow-up

Early tolerability/safety and BP review; symptom/function reassessment over weeks. Use closer suicide-risk monitoring where indicated and gradual taper when stopping.

Sources

Checked September 22, 2026.

Duloxetine (Cymbalta)Fibromyalgia

What to say

For fibromyalgia, start duloxetine 30 milligrams once daily for one week, then 60 milligrams daily if tolerated. The goal is to reduce widespread pain and help you stay active. It works gradually and complements the activity and rehabilitation plan. It isn’t an as-needed painkiller. Swallow the capsule whole.

Nausea, dry mouth, constipation, sweating or sleep changes can happen early. Tell me if they’re troublesome. We’ll check blood pressure and arrange an early review. Stop it and contact us the same day for yellow eyes or skin. Call the same day for worsening thoughts of self-harm, marked agitation or unusually high energy with little sleep. If you can’t stay safe, call 911. For ordinary planned stopping, we’ll reduce the dose gradually to limit symptoms such as dizziness and nausea. Tell me about substantial alcohol use or liver disease.

Clinical reference

Dose options

Fibromyalgia

30 mg orally once daily for one week, then 60 mg once daily

60 mg/day is the recommended target and maximum for this indication; higher doses have not shown added benefit and cause more adverse effects.

Organ function

Avoid with GFR <30 or chronic liver disease/cirrhosis

Review alcohol use, interactions and BP; taper planned discontinuation.

Before prescribing

Check indication, renal/liver disease, alcohol, BP, bipolar/suicide risk, serotonergic/MAOI and bleeding interactions. Discuss pregnancy and discontinuation rather than treating all indications identically.

Side effects and return precautions

GI, sweating, sleep and sexual effects; BP rise, hepatic injury, urinary retention, activation/suicidality and serotonin syndrome. Inability to pass urine needs immediate assessment.

Follow-up

Review tolerability, blood pressure, pain interference and function in 2–4 weeks. Reassess after a defined trial; taper if ineffective. Continue exercise/rehabilitation and other agreed non-drug treatment.

Sources

Checked September 23, 2026.

Duloxetine (Cymbalta)Generalized anxiety disorder

What to say

We’ll start duloxetine at 30 milligrams daily for a week, then increase to 60 milligrams if you’re tolerating it. The goal is reducing persistent worry and tension. Improvement builds over several weeks. Swallow the delayed-release capsule whole. Don’t open, crush or chew it. Food may help nausea.

Nausea, dry mouth, constipation, sweating or sleep changes can happen early. Tell me if they’re troublesome. We’ll check blood pressure and arrange an early review. Stop it and contact us the same day for yellow eyes or skin. Call the same day for worsening thoughts of self-harm, marked agitation or unusually high energy with little sleep. If you can’t stay safe, call 911. For ordinary planned stopping, we’ll reduce the dose gradually to limit symptoms such as dizziness and nausea. Tell me about substantial alcohol use or liver disease.

Clinical reference

Dose options

Generalized anxiety disorder

30 mg daily for one week, then 60 mg daily if tolerated

Usual adult dose 60 mg/day; maximum 120 mg/day. For geriatric GAD, use 30 mg for two weeks before considering 60 mg.

Organ function

Avoid with GFR <30 or chronic liver disease/cirrhosis

Review alcohol use, interactions and BP; taper planned discontinuation.

Before prescribing

Check indication, renal/liver disease, alcohol, BP, bipolar/suicide risk, serotonergic/MAOI and bleeding interactions. Discuss pregnancy and discontinuation rather than treating all indications identically.

Side effects and return precautions

GI, sweating, sleep and sexual effects; BP rise, hepatic injury, urinary retention, activation/suicidality and serotonin syndrome. Inability to pass urine needs immediate assessment.

Follow-up

Early tolerability/safety and BP review; symptom/function reassessment over weeks. Use closer suicide-risk monitoring where indicated and gradual taper when stopping.

Sources

Checked September 22, 2026.

Dutasteride (Avodart)Enlarged prostate (BPH)

What to say

For your enlarged prostate, take dutasteride 0.5 milligrams, 1 capsule once a day, with or without food. Swallow it whole; don’t chew or open it, because the contents can irritate your mouth and throat. It slowly shrinks the prostate, so improvement takes months. Over time it lowers the chance of being unable to urinate or needing surgery. It’s often paired with tamsulosin.

Lower sex drive, erection or ejaculation changes, and breast tenderness or enlargement can occur, and sexual effects sometimes persist after stopping. Report a breast lump, nipple discharge or low mood. It roughly halves your PSA blood test, so tell anyone checking your PSA. Don’t donate blood until 6 months after your last dose. Anyone who is or could be pregnant shouldn’t handle leaking capsules; wash any contact with soap and water. If you can’t urinate, go to urgent or emergency care.

Clinical reference

Dose options

Symptomatic BPH with an enlarged prostate

0.5 mg orally once daily, alone or with tamsulosin 0.4 mg daily

Swallow whole. Fixed combination Jalyn (0.5 mg/0.4 mg) once daily about 30 minutes after the same meal.

PSA interpretation

New baseline at least 3 months after starting; double an isolated value after ≥3 months of therapy

Investigate any confirmed rise from the on-treatment nadir, even within the untreated normal range. Percent free PSA needs no adjustment.

Organ function and interactions

No renal adjustment; hepatic impairment not studied

Extensively CYP3A4/5 metabolized; use caution with potent chronic CYP3A4 inhibitors (e.g., ritonavir).

Before prescribing

Confirm LUTS from BPH with prostatic enlargement; assess retention, infection and cancer as indicated. Record baseline PSA. Review hepatic disease and CYP3A4 inhibitors. 5-ARIs may increase high-grade prostate cancer risk.

Side effects and return precautions

Sexual dysfunction (may persist), breast enlargement or tenderness, depressed mood; male breast cancer reported. Retention needs urgent care. A confirmed PSA rise from nadir warrants evaluation.

Follow-up

Reassess symptoms at 3–6 months and periodically. Reset the PSA baseline after ≥3 months; advise no blood donation until 6 months after the last dose.

Sources

Checked October 15, 2026.

Elinzanetant (Lynkuet)Menopausal hot flashes

What to say

Elinzanetant is a nonhormone medicine for hot flashes and night sweats. Take two 60-milligram capsules, 120 milligrams in all, by mouth once a day at bedtime, with or without food. If you miss a dose, skip it. Avoid grapefruit and grapefruit juice. We’ll check liver blood tests before you start and again after 3 months. If pregnancy is possible, we’ll test first, and you’ll need reliable birth control during treatment and for 2 weeks after.

Sleepiness, tiredness, dizziness and headache are common. Don’t drive or do risky tasks while you feel drowsy, including the next morning. Stop it and contact us the same day for yellow skin or eyes, dark urine, pale stools, itching, nausea, vomiting or belly pain. Seizures have been reported rarely. Tell us about any past seizures, and call 911 for a seizure or passing out. Check with us before starting any new medicine. We’ll review benefit and side effects in about 4 weeks.

Clinical reference

Dose options

Moderate to severe VMS

120 mg (two 60-mg capsules) orally once daily at bedtime

With or without food; swallow whole. Missed dose: skip and resume the next night. Nonhormonal NK1/NK3 receptor antagonist.

CYP3A4 interactions

With a moderate CYP3A4 inhibitor: 60 mg once daily. Avoid strong CYP3A4 inhibitors, grapefruit, and moderate or strong CYP3A4 inducers

Moderate: diltiazem, verapamil, erythromycin, fluconazole, ciprofloxacin. Strong: clarithromycin, itraconazole, ketoconazole, ritonavir. Inducers: carbamazepine, phenytoin, rifampin, St. John’s wort. Weak CYP3A4 inhibitor: avoid narrow-margin CYP3A4 substrates.

Organ function

Not recommended with Child-Pugh B/C hepatic impairment or ESRD

No adjustment for eGFR 15–89 or Child-Pugh A.

  • Approved Oct 24, 2025; a seizure warning was added in Aug 2026. ACP (Oct 2026) suggests NK receptor antagonists third-line, after estrogen and an SNRI.

Before prescribing

Baseline ALT, AST, ALP and total/direct bilirubin; do not start if ALT/AST or bilirubin ≥2× ULN. Exclude pregnancy (contraindicated). Review CYP3A4 drugs, seizure history or lowered threshold, sedatives and driving needs.

Side effects and return precautions

Somnolence and next-day impairment, fatigue, dizziness, headache, abdominal pain, rash, diarrhea; rare seizures and photosensitivity. Stop for liver symptoms; discontinue if ALT/AST >5× ULN, or >3× ULN with bilirubin >2× ULN.

Follow-up

Repeat transaminases 3 months after starting and with symptoms. Reassess benefit and daytime sleepiness at 4–12 weeks; when relevant, contraception continues 2 weeks after stopping.

Sources

Checked October 15, 2026.

Empagliflozin (Jardiance)Chronic kidney disease

What to say

I’m starting empagliflozin 10 milligrams each morning to slow the loss of kidney function and reduce the risk of serious kidney and heart complications. Take it with or without food. This benefit can apply even without diabetes. A higher dose isn’t needed for this purpose. You may pee more, and some people get genital yeast infections. Contact us if you notice itching or discharge.

The important safety plan is for illness and fasting. Temporarily stop it if you’re sick and can’t eat or drink normally, and call us about restarting. Stop at least three days before surgery or a procedure involving prolonged fasting, using the dates we write down. If you have nausea or belly pain with vomiting, unusual exhaustion or fast breathing, stop it and go to the emergency department even if your sugar isn’t very high. If you also take insulin, don’t stop it on your own.

Clinical reference

Dose options

Chronic kidney disease

10 mg orally each morning

No dose escalation needed for this indication. HF/CKD trials enrolled eGFR ≥20; initiation below 20 or on dialysis was not studied.

Before prescribing

Check eGFR and volume status; review diuretics, insulin/sulfonylureas, pregnancy/breastfeeding, fasting/keto diet and prior ketoacidosis. Correct volume depletion. Not a type 1 diabetes treatment. Confirm CKD at risk of progression; label does not recommend this use for polycystic kidney disease or recent IV/high-dose immunosuppressive kidney treatment.

Side effects and return precautions

Volume depletion and genital infections are common practical concerns. Ketoacidosis can occur with modest glucose. Genital/perineal pain or swelling with fever needs emergency assessment.

Follow-up

Review intake, BP, volume status and kidney function as indicated, especially with diuretics, older age or CKD. Follow eGFR and albuminuria; interpret the early eGFR dip in clinical context. Resume after a hold only when stable and eating/drinking with an agreed plan.

Sources

Checked September 22, 2026.

Empagliflozin (Jardiance)Heart failure

What to say

I’m starting empagliflozin 10 milligrams each morning to reduce the risk of a heart-failure hospital stay or cardiovascular death. Take it with or without food. This benefit can apply even without diabetes. A higher dose isn’t needed for this purpose. You may pee more, and some people get genital yeast infections. Contact us if you notice itching or discharge.

The important safety plan is for illness and fasting. Temporarily stop it if you’re sick and can’t eat or drink normally, and call us about restarting. Stop at least three days before surgery or a procedure involving prolonged fasting, using the dates we write down. If you have nausea or belly pain with vomiting, unusual exhaustion or fast breathing, stop it and go to the emergency department even if your sugar isn’t very high. If you also take insulin, don’t stop it on your own.

Clinical reference

Dose options

Heart failure

10 mg orally each morning

No dose escalation needed for this indication. HF/CKD trials enrolled eGFR ≥20; initiation below 20 or on dialysis was not studied.

Before prescribing

Check eGFR and volume status; review diuretics, insulin/sulfonylureas, pregnancy/breastfeeding, fasting/keto diet and prior ketoacidosis. Correct volume depletion. Not a type 1 diabetes treatment.

Side effects and return precautions

Volume depletion and genital infections are common practical concerns. Ketoacidosis can occur with modest glucose. Genital/perineal pain or swelling with fever needs emergency assessment.

Follow-up

Review intake, BP, volume status and kidney function as indicated, especially with diuretics, older age or CKD. Review heart-failure symptoms, weight and diuretic need. Resume after a hold only when stable and eating/drinking with an agreed plan.

Sources

Checked September 22, 2026.

Empagliflozin (Jardiance)Type 2 diabetes

What to say

I’m starting empagliflozin 10 milligrams each morning to lower blood sugar. Take it with or without food. We’ll review your glucose readings before deciding whether you need a higher dose. You may pee more, and some people get genital yeast infections. Contact us if you notice itching or discharge.

The important safety plan is for illness and fasting. Temporarily stop it if you’re sick and can’t eat or drink normally, and call us about restarting. Stop at least three days before surgery or a procedure involving prolonged fasting, using the dates we write down. If you have nausea or belly pain with vomiting, unusual exhaustion or fast breathing, stop it and go to the emergency department even if your sugar isn’t very high. Don’t stop prescribed insulin on your own.

Clinical reference

Dose options

Type 2 diabetes

10 mg orally each morning

For additional glucose lowering, may increase to 25 mg daily if tolerated; glycemic use not recommended at eGFR <30.

Before prescribing

Check eGFR and volume status; review diuretics, insulin/sulfonylureas, pregnancy/breastfeeding, fasting/keto diet and prior ketoacidosis. Correct volume depletion. Not a type 1 diabetes treatment.

Side effects and return precautions

Volume depletion and genital infections are common practical concerns. Ketoacidosis can occur with modest glucose. Genital/perineal pain or swelling with fever needs emergency assessment.

Follow-up

Review intake, BP, volume status and kidney function as indicated, especially with diuretics, older age or CKD. Review glucose and A1c response. Resume after a hold only when stable and eating/drinking with an agreed plan.

Sources

Checked September 22, 2026.

Emtricitabine/tenofovir AF (Descovy)HIV prevention (PrEP)

What to say

Descovy is a daily pill to help prevent HIV from sex. Take one 200/25-milligram tablet every day, with or without food. It isn’t the appropriate PrEP option for exposure through receptive vaginal sex. We would choose another option for that.

We’ll check HIV, kidney function and hepatitis B before starting, then HIV at least every three months. Nausea can occur. Don’t stop without a plan if you have hepatitis B, because stopping can inflame your liver. Call promptly for flu-like symptoms after an exposure or missed doses. PrEP doesn’t prevent other STIs or replace emergency PEP after a recent exposure.

Clinical reference

Dose options

Daily PrEP, weight ≥35 kg

Emtricitabine 200 mg/tenofovir alafenamide 25 mg orally daily

Routine eligibility: eCrCl ≥30 mL/min. The label also permits adults on chronic hemodialysis; coordinate that regimen with specialist care.

Before prescribing

Exclude HIV using the current testing algorithm; assess exposure route, recent PEP need, HBV, renal function, lipids and interacting drugs. Not approved for receptive vaginal exposure or established for injection-related exposure.

Side effects and return precautions

GI symptoms, kidney injury, lipid/weight changes, HBV flare after stopping and resistance with undiagnosed HIV.

Follow-up

HIV Ag/Ab and RNA at least every 3 months; limit refills to 90 days. Monitor kidneys by risk, at least annually; annual weight/lipids and site-specific STI screening. Write down the protection-onset and missed-dose plan.

Sources

Checked September 23, 2026.

Emtricitabine/tenofovir DF (Truvada)HIV prevention (PrEP)

What to say

This daily pill helps prevent HIV. After confirming your HIV and kidney test results, take one tablet containing emtricitabine 200 milligrams and tenofovir DF 300 milligrams every day, with or without food. It isn’t emergency treatment after a recent exposure, and it doesn’t prevent other sexually transmitted infections.

Nausea or stomach discomfort may occur at first. Protection builds with consistent use. We’ll write down when you can rely on it for the type of exposure relevant to you. Keep condoms or other prevention measures in place during that time. We’ll repeat HIV testing at least every three months and check kidneys and other infections on the schedule we set. Call promptly for fever, rash, sore throat or other flu-like symptoms after an exposure. If you have hepatitis B, don’t stop these tablets without a plan because stopping can inflame the liver.

Call immediately after a possible HIV exposure before protection is established or after missed doses. A separate emergency treatment called PEP must start within 72 hours, preferably as soon as possible. Use urgent care or the emergency department if you can’t reach us.

Clinical reference

Dose options

Daily oral PrEP, adult ≥35 kg

Emtricitabine 200 mg/tenofovir disoproxil fumarate 300 mg: one tablet orally daily

Confirm HIV-negative status and renal eligibility. This is F/TDF, not the different F/TAF product.

Kidney eligibility

U.S. label: do not use for PrEP if estimated CrCl <60 mL/min

CDC online initiation wording uses >60; assess borderline results individually. Do not use HIV-treatment renal interval reductions as a PrEP regimen.

Protection / alternatives

Maximal drug levels associated with protection: about 7 daily doses for receptive anal sex; up to 21 for receptive vaginal sex or injection drug use

Timing for insertive sex is not established. Event-driven 2-1-1 is off-label and not recommended by CDC; it is not this daily plan.

Before prescribing

Use the current HIV testing algorithm; assess acute infection, recent exposure needing PEP, renal function, hepatitis B, STIs and pregnancy. Check nephrotoxic drugs and bone risk. Positive/ambiguous HIV tests require evaluation before continuing a two-drug prevention regimen.

Side effects and return precautions

Early GI symptoms/headache; renal and bone effects, hepatitis B flare with stopping, and resistance if used during unrecognized HIV infection. A recent exposure with inadequate protection needs urgent PEP assessment, within 72 hours.

Follow-up

CDC oral PrEP: HIV Ag/Ab and HIV-1 RNA at least every 3 months; authorize ≤90 days until next HIV test. Renal review at least every 6 months if age ≥50 or baseline CrCl <90, more often with risk; at least annually for everyone. Site-specific STI screening and adherence review according to risk.

Sources

Checked September 20, 2026.

Epinephrine auto-injector (EpiPen)Anaphylaxis

What to say

This EpiPen 0.3-milligram device is for a severe allergic reaction. Use it immediately for throat swelling, breathing trouble or faintness after an exposure, or the combination of symptoms in your written allergy plan. An antihistamine isn’t a substitute.

Let’s practice with the trainer. Remove the blue safety cap, keep fingers away from the orange end, and press the orange end firmly against the outer thigh, through clothing if necessary. Hold for three seconds. Call 911 after giving it. If symptoms persist or return, use your second device after about five minutes while emergency help is coming. A racing heart, shakiness or anxiety can happen after the dose. Carry both devices, check the expiration regularly and make sure the liquid is clear and colorless, and replace any used device. We’ll review your trigger and emergency plan together.

Clinical reference

Dose options

EpiPen at weight ≥30 kg

0.3 mg by auto-injector into the outer thigh for anaphylaxis

Hold an EpiPen in place for 3 seconds. Other devices have different instructions.

Repeat / weight distinction

If symptoms persist/return, a second dose may be needed after about 5 minutes under the emergency plan

More than two sequential doses should be under direct medical supervision. EpiPen Jr 0.15 mg is a different weight-based product.

Route and handling

Outer-thigh injection, through clothing if needed; single-use device

Never inject into fingers, hands, feet or buttocks; accidental injection requires immediate medical advice.

Before prescribing

Confirm anaphylaxis risk, patient weight, device access and ability of patient/household to demonstrate use. Provide two doses, an individualized written plan and allergy referral when indicated. There is no absolute contraindication to epinephrine in life-threatening anaphylaxis.

Side effects and return precautions

Tachycardia, tremor, pallor and anxiety are expected possible effects. Undertreated anaphylaxis is the immediate danger; do not delay treatment for fear of these effects. Emergency assessment is still needed after this plan’s use.

Follow-up

Review trainer technique and expirations at visits; replace after use and reassess trigger, recurrence risk and emergency plan after every reaction.

Sources

Checked September 20, 2026.

Epinephrine nasal spray (neffy)Anaphylaxis

What to say

Neffy is an epinephrine nose spray for a severe allergic reaction (anaphylaxis). Use it right away for signs such as trouble breathing, throat or tongue swelling, repeated vomiting, or dizziness or fainting after a trigger. Your dose is 1 spray of 2 milligrams. Put the nozzle fully into one nostril, hold it straight, and press the plunger firmly. Don’t sniff afterward, and don’t test it first. If you aren’t better or get worse, use the second spray in the same nostril after 5 minutes. Always carry both.

Call 911 right after you use it, even if you feel better, because symptoms can return. Common side effects are nasal discomfort, throat irritation, headache and dizziness. Tell us if you have nasal polyps, a broken nose or nose surgery, since the spray may not absorb well. Don’t let it freeze, and replace it before it expires.

Clinical reference

Dose options

Anaphylaxis, adults and patients 30 kg or more

neffy 2 mg: 1 spray in one nostril; if no improvement or symptoms worsen, give a second spray in the same nostril with a new device starting 5 minutes after the first

Prescribe the 2-device carton and have the patient carry both. More than two sequential doses need direct medical supervision. The 1 mg strength is for 15 to under 30 kg.

Storage and handling

Keep in the blister pack or carry case at 20–25 °C (68–77 °F); excursions to 50 °C (122 °F) allowed; do not freeze

A frozen device will not spray but works after thawing. In an emergency, do not wait to thaw: seek emergency care. Never prime or test. Replace before expiry.

  • Approved on pharmacokinetic and pharmacodynamic studies in people without anaphylaxis, not on anaphylaxis outcome trials (label). Injectable epinephrine remains the established option.

Before prescribing

Confirm weight of at least 30 kg for 2 mg. With nasal polyps or prior nasal fracture, injury or surgery, consider injectable epinephrine (label). Review cardiac disease and interacting drugs (TCAs, MAOIs, beta blockers, levothyroxine).

Side effects and return precautions

Nasal discomfort, throat irritation, headache, dizziness; jitteriness after a second dose. Heart disease raises arrhythmia risk but does not contraindicate use. For up to 2 weeks after a dose, neffy may increase absorption of nasal products, including neffy.

Follow-up

Teach the device and emergency plan; replace after use or expiry. The 2023 parameter says immediate EMS may not be needed if the response is prompt, complete and durable; agree on this plan in advance.

Sources

Checked October 15, 2026.

Ergocalciferol (Drisdol)Vitamin D deficiency

What to say

Your testing shows vitamin D deficiency that needs treatment. For this replacement course, take one 50,000-unit ergocalciferol capsule once a week for eight weeks. Choose a weekday and mark each dose on your calendar. This is a weekly prescription, so don’t take it every day or continue refilling it indefinitely. You may not notice a change in how you feel.

Bring us the labels of any vitamins or calcium you already take so we can avoid duplicate dosing. Call the same day for persistent nausea, constipation, unusual thirst, or much more urination. These can signal high calcium. Go to the emergency department for severe confusion or repeated vomiting. We’ll review your response and calcium and vitamin D testing around the end of the course, then choose any lower maintenance dose you need. If you miss a weekly dose, check the replacement schedule with the pharmacist. Don’t double it.

Clinical reference

Dose options

Established deficiency

Vitamin D2 50,000 IU orally once weekly for 8 weeks

Historical Endocrine Society 2011 replacement regimen; 1.25 mg = 50,000 IU. Individualize to severity and context; this is not routine prevention.

After replacement

Choose a lower maintenance regimen after reassessment

Historical regimen uses 1,500–2,000 IU/day D2 or D3. Current prevention guidance favors lower daily rather than intermittent high doses for adults ≥50 with an indication; consider daily D3 instead.

Complex disease

Individualize; do not reuse routine loading automatically

Advanced CKD, granulomatous disease, malabsorption, hyperparathyroidism and pregnancy need a tailored plan; avoid treatment in hypercalcemia.

Before prescribing

Confirm an established indication, 25-OH vitamin D, calcium and renal status. Review duplicate vitamin D/calcium, thiazides and digoxin. Ordinary deficiency replacement differs from the very high doses in product labeling for vitamin-D-resistant rickets/hypoparathyroidism.

Side effects and return precautions

Excess dosing can produce hypercalcemia and kidney injury. Persistent GI symptoms, polyuria or thirst require prompt review and withholding further high doses until advised; severe confusion/dehydration needs urgent care.

Follow-up

Record the eight-dose stop date and review around 8–12 weeks; select calcium and 25-OH-D testing by clinical context, earlier calcium monitoring for higher risk. Do not carry forward historical universal screening or >30-ng/mL targets as current prevention policy.

Sources

Checked September 20, 2026.

Escitalopram (Lexapro)Depression

What to say

For depression, start escitalopram 10 milligrams once daily. We’ll follow your mood, interest in activities and daily functioning over the next several weeks. Take it with or without food. We can adjust the time if it makes you sleepy or keeps you awake.

Benefit builds over several weeks. Nausea, headache, sleep changes or sexual side effects can occur, so please tell me rather than stopping without a plan. We’ll check in early about side effects and safety, then decide whether the dose is helping. Call the same day for new thoughts of self-harm, marked restlessness or unusually high energy with very little sleep. If you can’t stay safe, call 911. You can also call or text 988 for immediate crisis support. We’ll reduce gradually if stopping later is appropriate.

Clinical reference

Dose options

Adult depression

10 mg orally once daily

Standard labeled adult starting dose for major depressive disorder.

Tolerability option

5 mg daily before increasing

A lower start for tolerability; not the label’s standard adult starting dose.

Maximum / special groups

20 mg/day; label permits increase after ≥1 week

Older adults/hepatic impairment: recommended 10 mg/day. Mild/moderate renal impairment: no adjustment; CrCl <20 dose undetermined. Higher dose is not automatically more effective.

Before prescribing

Assess safety, bipolarity, MAOIs/serotonergic drugs, QT-risk context and sodium risk. Review renal/hepatic function when relevant and discuss pregnancy without abrupt self-discontinuation.

Side effects and return precautions

GI, sleep and sexual effects; activation/suicidality, hyponatremia, serotonin syndrome and bleeding. Fainting with an abnormal heartbeat warrants urgent/emergency assessment.

Follow-up

Review within two weeks; within one week for ages 18–25 or increased suicide risk. Track mood, function and tolerability before changing the dose; taper planned discontinuation.

Sources

Checked September 23, 2026.

Escitalopram (Lexapro)Generalized anxiety disorder

What to say

For persistent anxiety, start escitalopram 10 milligrams once daily. The goal is less uncontrollable worry and tension and more freedom to do your usual activities. Take it every day, with or without food. It isn’t immediate relief for a panic attack.

Benefit builds over several weeks. Nausea, headache, sleep changes or sexual side effects can occur, so please tell me rather than stopping without a plan. We’ll check in early about side effects and safety, then decide whether the dose is helping. Call the same day for new thoughts of self-harm, marked restlessness or unusually high energy with very little sleep. If you can’t stay safe, call 911. You can also call or text 988 for immediate crisis support. We’ll reduce gradually if stopping later is appropriate.

Clinical reference

Dose options

Adult generalized anxiety disorder

10 mg orally once daily; maximum 20 mg/day

Label permits an increase after at least one week, but judge response and tolerability. Starting at 5 mg can help tolerability.

Maximum / special groups

20 mg/day; label permits increase after ≥1 week

Older adults/hepatic impairment: recommended 10 mg/day. Mild/moderate renal impairment: no adjustment; CrCl <20 dose undetermined. Higher dose is not automatically more effective.

Before prescribing

Assess safety, bipolarity, MAOIs/serotonergic drugs, QT-risk context and sodium risk. Review renal/hepatic function when relevant and discuss pregnancy without abrupt self-discontinuation.

Side effects and return precautions

GI, sleep and sexual effects; activation/suicidality, hyponatremia, serotonin syndrome and bleeding. Fainting with an abnormal heartbeat warrants urgent/emergency assessment.

Follow-up

Review effectiveness and adverse effects every 2–4 weeks during the first three months. For adults under 30, review within one week and monitor self-harm/suicide risk weekly for the first month, following NICE GAD guidance. Taper planned discontinuation.

Sources

Checked September 23, 2026.

Estradiol tablets (Estrace)Menopausal hot flashes

What to say

For your hot flashes and night sweats, take estradiol 0.5 milligrams by mouth once a day, every day, at about the same time. If you still have a uterus, you’ll also take progesterone on the written schedule to protect its lining. Full relief at this dose can take 6–8 weeks. If symptoms are still bothersome then, we may increase to 1 milligram. This treatment isn’t birth control.

Breast tenderness, bloating, nausea, headache or spotting can happen. Tell us about bleeding that’s heavy, lasts, or starts after it had stopped, rather than assuming it’s harmless. Stop it and call 911 for chest pain, sudden breathlessness, a drooping face, arm weakness, trouble speaking or sudden vision loss. Stop it and get same-day care for a painful, swollen leg. Tell us before surgery or long bed rest. We’ll review symptoms, bleeding and blood pressure in 8–12 weeks, then at least yearly, and decide together whether to continue.

Clinical reference

Dose options

Menopausal vasomotor symptoms

Start 0.5 mg orally once daily, continuously; increase to 1 mg daily if needed after 6–8 weeks

Label: usual initial 1–2 mg/day, cyclic (3 weeks on, 1 off). Guidelines use the lowest effective daily dose; ≤0.5 mg/day may take 6–8 weeks for full relief. Brand Estrace tablets are discontinued; generic 0.5-, 1- and 2-mg tablets.

If the uterus is present

Add adequate progestogen, e.g., micronized progesterone 200 mg at bedtime for 12–14 days each month

Continuous regimens are alternatives (see progesterone entry). Investigate unscheduled bleeding beyond 6 months of combined therapy and any persistent or recurrent bleeding.

Oral vs transdermal route

Prefer transdermal estradiol with VTE or stroke risk factors or gallbladder disease

Observational data suggest lower VTE, stroke and gallstone risk with transdermal estrogen; no head-to-head RCTs. Prior VTE contraindicates either route.

  • On Feb 12, 2026, FDA approved labels without the boxed cardiovascular, breast cancer and dementia statements for six MHT products, none an estradiol tablet; current estradiol tablet labels still carry the full boxed warning.

Before prescribing

Confirm bothersome VMS, uterus status, pregnancy possibility and no undiagnosed bleeding. Contraindicated: breast/estrogen-dependent cancer, prior VTE or thrombophilia, stroke, MI/CHD, liver disease. Benefit-risk is less favorable when starting after 60 or >10 years past menopause.

Side effects and return precautions

Breast tenderness, bloating, nausea, headache, bleeding. VTE, stroke, MI, gallbladder disease, triglyceride-related pancreatitis, retinal thrombosis. Stop 4–6 weeks before high-VTE-risk surgery or prolonged immobilization if feasible.

Follow-up

Review at 8–12 weeks (symptoms, bleeding, BP), then at least yearly: indication, lowest effective dose, route, progestogen adherence, breast screening. No routine age-based stop; VMS recur in about half after stopping.

Sources

Checked October 15, 2026.

Estradiol twice-weekly patch (Vivelle-Dot, Dotti)Menopausal hot flashes

What to say

For your menopausal hot flashes, we’re starting an estradiol patch that delivers 0.0375 milligrams per day. Replace it twice weekly, for example Monday morning and Thursday evening. Apply it to clean, dry skin on the lower abdomen or buttock, away from the breasts and waistband, and rotate sites. Remove the old patch first and don’t cut patches.

Because you still have a uterus, your written plan also includes progesterone to protect its lining. This treatment doesn’t prevent pregnancy. Breast tenderness, headache or spotting can occur. Tell us about unexpected or persistent bleeding rather than assuming it’s harmless. Stop and call 911 for chest pain, sudden breathlessness, a drooping face, arm weakness or trouble speaking. We’ll review symptoms and side effects in eight to twelve weeks and adjust the dose if needed. Let’s know if your health history changes.

Clinical reference

Dose options

Menopausal vasomotor symptoms

Start 0.0375 mg/day delivery, replacing the patch twice weekly

This entry uses a twice-weekly system. A once-weekly patch has different replacement instructions.

Available delivery strengths

0.025, 0.0375, 0.05, 0.075 and 0.1 mg/day

Choose the lowest effective dose; the printed daily delivery is not the total drug in the patch.

If the uterus is present

Add an adequate progestogen regimen

For example, oral micronized progesterone 200 mg at bedtime for 12 days of each 28-day cycle; match protection to estrogen dose and bleeding pattern.

Before prescribing

Clarify menopause symptoms, uterus status, pregnancy possibility and unexplained bleeding. Review breast/endometrial cancer, VTE/stroke, coronary disease and liver disease contraindications. Systemic therapy is not contraception or primary cardiovascular prevention; isolated vaginal symptoms often need local treatment instead.

Side effects and return precautions

Breast discomfort, headache and spotting are common. New unilateral leg swelling needs urgent clot assessment; chest pain, dyspnea or focal neurologic symptoms require emergency care. Investigate concerning bleeding. Transdermal delivery does not erase systemic hormone risks.

Follow-up

Review symptoms, bleeding and tolerance at 8–12 weeks; periodically reassess indication, dose, risk and progestogen adherence. Duration is individualized rather than governed by an automatic stop date.

Sources

Checked September 20, 2026.

Evolocumab (Repatha)LDL cholesterol lowering

What to say

Evolocumab is an injection that lowers LDL, the “bad” cholesterol, by about half or more on top of your statin, and lowers the chance of a heart attack or stroke. Inject 140 milligrams under the skin every 2 weeks; some people instead use 420 milligrams once a month. Refrigerate it, and let it warm up for 30 minutes before injecting. If you’re up to 7 days late, inject it and keep your schedule; if later, call us.

Side effects are usually mild: cold symptoms, back pain, or redness and soreness where you inject. For hives or a rash, call us; for swelling of the face, lips or tongue, or trouble breathing, call 911. Tell us if you’re allergic to latex, since some devices contain it. Keep taking your statin unless we say otherwise. We’ll recheck your cholesterol in 4–12 weeks.

Clinical reference

Dose options

Adults with ASCVD, increased CV risk or hypercholesterolemia

140 mg SC every 2 weeks, or 420 mg SC once monthly

Missed dose ≤7 days: give and resume schedule. >7 days: every-2-week users wait for the next scheduled dose; monthly users give it and start a new schedule from that date. When switching regimens, start on the next scheduled date.

Storage and devices

Refrigerate at 2–8 °C; may keep at 20–25 °C in the carton for up to 30 days

Don’t freeze or shake. Warm ≥30 minutes before use. 420 mg is 3 consecutive 140 mg injections within 30 minutes. SureClick autoinjector and prefilled syringe needle covers contain dry natural rubber (latex).

  • The Aug 2026 label covers MACE reduction in adults at increased CV risk; the 2026 guideline text still lists primary-prevention outcome data (VESALIUS-CV) as pending.

Before prescribing

Confirm LDL-C above goal on maximally tolerated statin ± ezetimibe (2026 ACC/AHA: <55 mg/dL very high-risk ASCVD, <70 mg/dL other ASCVD). Prior serious hypersensitivity contraindicates; ask about latex. Prior authorization is usually needed.

Side effects and return precautions

Nasopharyngitis, URI, influenza, back pain, injection-site reactions. Hypersensitivity including angioedema: stop and treat. Expect 45–64% LDL-C lowering; a poor response suggests missed doses or technique problems.

Follow-up

Lipid panel 4–12 weeks after starting, then every 6–12 months. Review adherence and injection technique if LDL-C stays above goal. Alirocumab is the alternative if the formulary requires it.

Sources

Checked October 15, 2026.

Ezetimibe (Zetia)Cholesterol lowering

What to say

Ezetimibe lowers the amount of cholesterol your intestine absorbs. Take 10 milligrams once a day, with or without food. We’re adding it because we want to lower your LDL, or bad cholesterol, further with the treatment you can tolerate.

You may notice diarrhea or mild joint or muscle aches. Tell me if these persist. Severe muscle pain or weakness with dark urine means stop it and go to the emergency department. Check before adding medicines, especially if you also use a cholesterol-binding powder. We’ll repeat cholesterol in about four to twelve weeks and decide whether the result meets our goal.

Clinical reference

Dose options

Adult LDL lowering

10 mg orally once daily

Used alone when appropriate or with other LDL-lowering therapy; no upward dose titration.

Bile-acid sequestrant separation

Take ≥2 hours before or ≥4 hours after a bile-acid sequestrant

Examples include cholestyramine; check the whole medication schedule.

Organ function

No renal adjustment; not recommended in moderate/severe hepatic impairment

Combination with a statin requires that statin’s precautions as well.

Before prescribing

Review baseline lipids, treatment goal, hepatic disease, statin tolerance, pregnancy and interactions including cyclosporine/fibrates. Select add-on therapy from ASCVD risk and required reduction.

Side effects and return precautions

Diarrhea and arthralgia; myopathy and liver-enzyme elevations are uncommon but relevant, especially in combinations. Yellow eyes/skin needs prompt evaluation.

Follow-up

Recheck lipids about 4–12 weeks after initiation; assess adherence and symptoms. Liver testing as clinically indicated and per accompanying statin plan.

Sources

Checked September 20, 2026.

Famotidine (Pepcid)Nonerosive gastroesophageal reflux disease

What to say

For the reflux symptoms we’ve discussed, take famotidine 20 milligrams twice a day. This is a scheduled course. Occasional-heartburn dosing is different. You can take it with or without food. We’ll review the response during this course and decide whether you still need it.

Headache, dizziness, constipation or diarrhea can happen. Tell me if these are troublesome, and call the same day for new confusion. Kidney problems can mean a lower dose, so check with us before changing the schedule. Trouble swallowing or persistent vomiting needs prompt assessment. Vomiting blood or black tarry stools means go to the emergency department. For new or severe chest pressure, especially with breathlessness, sweating or faintness, call 911.

Clinical reference

Dose options

Nonerosive GERD

20 mg orally twice daily, up to 6 weeks

Prescribed course, then reassess.

Occasional OTC heartburn: 10-mg product

10 mg as needed or 15–60 minutes before a trigger; maximum two 10-mg tablets in 24 hours

Review if needed beyond 14 days; other OTC strengths have their own label.

GERD renal adjustment

CrCl 30 to <60: maximum 20 mg daily; CrCl <30: 20 mg every other day or 10 mg daily

Use a suitable formulation and the current indication-specific renal table.

Before prescribing

Check renal function, age/confusion risk, alarm symptoms and interacting medicines whose absorption depends on acidity. Do not copy hypersecretory-condition high doses into routine reflux care.

Side effects and return precautions

Headache, bowel changes and dizziness; CNS effects are more concerning in older/renally impaired patients. New confusion requires same-day evaluation; severe confusion emergency care.

Follow-up

Set a symptom review within the prescribed course; do not extend OTC self-treatment beyond two weeks without review. Reassess frequent recurrence or nonresponse.

Sources

Checked September 20, 2026.

Febuxostat (Uloric)Long-term gout prevention

What to say

Febuxostat lowers uric acid to prevent gout attacks; we usually use it when allopurinol hasn’t worked or isn’t suitable. Take 40 milligrams once a day, even when you feel well. It doesn’t treat an attack that’s happening now. We’ll check your uric acid in 2 weeks and adjust the dose. Take [flare-prevention medicine] for at least the first 3–6 months.

Early attacks don’t mean it’s failing; keep taking it and follow your flare plan. In people with heart disease, it was linked to more deaths from heart problems than allopurinol, so tell us about any heart or blood vessel disease. Call 911 for chest pain, shortness of breath, sudden weakness or trouble speaking. Call the same day for a new rash, yellow skin or eyes, or dark urine; a blistering or peeling rash means stop it and go to the emergency department. Never combine it with azathioprine or mercaptopurine.

Clinical reference

Dose options

Start and titrate

40 mg once daily; increase to 80 mg if serum urate is ≥6 mg/dL after 2 weeks

ACR 2020 strongly recommends starting ≤40 mg/day and treating to urate <6 mg/dL. Severe renal impairment: label limits to 40 mg daily.

Flare prophylaxis

Colchicine, an NSAID or low-dose prednisone when starting; continue at least 3–6 months

ACR 2020: extend if flares continue; the label says prophylaxis may help for up to 6 months. Don’t stop febuxostat for a flare.

  • Not recommended for asymptomatic hyperuricemia.

Before prescribing

Label: use only after allopurinol failure, intolerance or unsuitability. Boxed warning: more CV deaths than allopurinol in established CVD (CARES). Contraindicated with azathioprine/mercaptopurine; caution with theophylline. Baseline LFTs; ask about prior allopurinol skin reactions.

Side effects and return precautions

Early flares; CV events; hepatotoxicity (check LFTs promptly for fatigue, RUQ pain, dark urine or jaundice); SJS/TEN/DRESS, especially after prior allopurinol reactions.

Follow-up

Recheck urate 2 weeks after starting and after dose changes until <6 mg/dL, then periodically. ACR 2020 favors switching agents with CVD or a new CV event. Review prophylaxis at 3–6 months.

Sources

Checked October 15, 2026.

Fenofibrate (Tricor)High triglycerides

What to say

Fenofibrate lowers triglycerides, a type of fat in your blood. When they’re very high, they can inflame the pancreas, which can be serious. Take [dose] once a day, with or without food. Fenofibrate products come in different strengths, so don’t switch brands unless we change the prescription. Your food plan matters as much as the pill: cut back on sugar, refined starches and alcohol, which push triglycerides up quickly. We’ll recheck your levels in 4 to 8 weeks.

Stomach upset, back pain or headache can happen. Call us promptly about unexplained muscle pain or weakness, especially with dark urine or if you also take a statin. Call the same day for yellow skin or eyes, or pain under your right ribs. Severe belly pain, especially with vomiting, or a blistering rash or rash with fever means stop it and go to the emergency department. If you take warfarin, we’ll check your INR more often. Don’t breastfeed while taking it.

Clinical reference

Dose options

Severe hypertriglyceridemia (Tricor tablets)

48–145 mg once daily, with or without food; adjust every 4–8 weeks; maximum 145 mg

Stop if the response is inadequate after 2 months at 145 mg. Other products (micronized capsules, fenofibric acid) use different, non-equivalent strengths, and some must be taken with meals.

Renal impairment

eGFR 30–59: start 48 mg and increase only after checking renal function and lipids

Contraindicated in severe renal impairment (eGFR <30), including dialysis. Creatinine can rise reversibly. ACC’s 2026 guideline summary advises avoiding fibrates in CKD.

  • Lowers TG about 30–50% but has not reduced CV events added to statins; the 2026 ACC/AHA guideline uses fibrates or prescription omega-3s mainly to cut pancreatitis risk at TG ≥500 mg/dL, especially ≥1,000.

Before prescribing

Confirm fasting TG ≥500 mg/dL (especially ≥1,000); address diabetes, alcohol, hypothyroidism, CKD and drugs such as estrogens, thiazides, beta-blockers and steroids. Check eGFR, LFTs and CBC. Contraindicated with breastfeeding, active liver or gallbladder disease.

Side effects and return precautions

Myopathy and rhabdomyolysis (higher with statins, colchicine, older age, CKD, hypothyroidism), hepatotoxicity, gallstones, pancreatitis, reversible creatinine rise, VTE, paradoxical HDL fall and severe skin reactions. Potentiates warfarin.

Follow-up

Fasting lipids every 4–8 weeks while adjusting, and HDL-C in the first months. LFTs at baseline and periodically; renal function with CKD, older age or diabetes; CBC during the first year.

Sources

Checked October 15, 2026.

Ferrous sulfate (Feosol Original)Iron-deficiency anemia

What to say

Your blood tests show iron-deficiency anemia. Start one ferrous sulfate 325-milligram tablet once a day. That tablet contains 65 milligrams of elemental iron. Check the bottle because different iron products contain different amounts. It absorbs best on an empty stomach, but taking it with a little food is reasonable if it upsets your stomach. We’ll check the timing against your other medicines.

Constipation, nausea, and darker stools are common. Call if side effects keep you from taking it. Every-other-day dosing may work better. Go to the emergency department for black, sticky stools with pain, dizziness or weakness, or for vomiting blood. Call 911 for fainting or severe weakness. Keep iron locked away from children. We’ll repeat your blood count in about four weeks and continue investigating why you became iron deficient. Treatment usually continues after the anemia improves to refill your iron stores.

Clinical reference

Dose options

Oral replacement

65 mg elemental iron once daily

Usually one immediate-release ferrous sulfate 325-mg tablet; verify elemental content. Do not substitute salt weights across products.

Tolerance alternative

65 mg elemental iron every other day

AGA recommends oral iron at most once daily; alternate-day dosing may improve tolerance. Consider IV iron if oral therapy fails or absorption is unlikely.

Duration

Often about 3 months after hemoglobin normalizes

Adjust to ferritin, ongoing loss and clinical response; not an indefinite supplement for unexplained anemia.

Before prescribing

Confirm iron deficiency and evaluate bleeding/malabsorption. Check CBC and ferritin, medication timing and iron-overload risk. Separate levothyroxine by at least 4 hours; review antibiotic, antacid and calcium spacing individually.

Side effects and return precautions

Dark stools alone are expected; tarry stools, red blood, persistent pain or systemic symptoms need assessment. Iron overdose is an emergency: contact Poison Control immediately (1-800-222-1222 in the U.S.), especially for a child.

Follow-up

CBC within 4 weeks, earlier if severe/symptomatic. Check adherence, absorption and continuing blood loss if response is inadequate; reassess ferritin/repletion and finish the cause-of-anemia evaluation.

Sources

Checked September 20, 2026.

Fezolinetant (Veozah)Menopausal hot flashes

What to say

Fezolinetant is a nonhormone medicine for hot flashes and night sweats. Take one 45-milligram tablet by mouth once a day, at about the same time, with or without food. If you miss a dose, take it the same day if your next dose is at least 12 hours away; otherwise, skip it. We’ll check liver blood tests before you start, every month for the first 3 months, and at 6 and 9 months.

Belly pain, diarrhea, trouble sleeping and back pain can happen. Rarely, it harms the liver. Stop it and contact us the same day for yellow skin or eyes, dark urine, pale stools, itching, nausea, vomiting, unusual tiredness, poor appetite or belly pain. Go to the emergency department for confusion or extreme sleepiness with yellow skin. It can’t be combined with some medicines, including fluvoxamine, ciprofloxacin, cimetidine and birth control pills, so check with us before starting anything new. We’ll review it after about 12 weeks.

Clinical reference

Dose options

Moderate to severe VMS

45 mg orally once daily, with or without food; swallow whole

No titration. Missed dose: take it the same day unless <12 hours remain before the next dose. Nonhormonal NK3 receptor antagonist.

Do not use

Known cirrhosis, eGFR <30 (including ESRD) or any CYP1A2 inhibitor

No adjustment for eGFR 30–89. CYP1A2 inhibitors include fluvoxamine, ciprofloxacin, mexiletine, oral contraceptives, cimetidine, acyclovir, allopurinol and zileuton.

  • ACP (Oct 2026) suggests NK receptor antagonists third-line, after estrogen and an SNRI; The Menopause Society (2023) recommends fezolinetant (Level I).

Before prescribing

Baseline ALT, AST, ALP and total/direct bilirubin; do not start if ALT/AST or bilirubin ≥2× ULN. Contraindicated: cirrhosis, eGFR <30, any CYP1A2 inhibitor. Discuss hormone therapy as the more effective option when suitable.

Side effects and return precautions

Abdominal pain, diarrhea, insomnia, back pain. Boxed hepatotoxicity: DILI reported within 40 days of starting. Stop for liver symptoms, ALT/AST >5× ULN, or >3× ULN with bilirubin >2× ULN; test more often if >3× ULN.

Follow-up

LFTs monthly for 3 months, then at 6 and 9 months, and with symptoms. Reassess benefit by 12 weeks; stop if not meaningfully helpful.

Sources

Checked October 15, 2026.

Finasteride (Propecia)Male-pattern hair loss

What to say

For your male-pattern hair loss, we’re starting finasteride 1 milligram by mouth daily, with or without food. It can slow further thinning and sometimes regrow hair, but judge it over months. Take baseline photographs and we’ll compare them in three to six months. Benefits fade after stopping. Taking extra doesn’t work faster.

Reduced sex drive, erection problems or ejaculation changes can occur. Tell us about these or new breast changes. Stop it and contact us the same day for new depression or thoughts of self-harm. Call 911 if you can’t stay safe. Anyone who is pregnant or could be pregnant shouldn’t handle crushed or broken tablets. Tell anyone ordering a PSA blood test that you take finasteride, because it lowers the result. If you miss a dose, skip it and resume the usual schedule. Don’t double up.

Clinical reference

Dose options

Male-pattern hair loss

1 mg orally once daily

Assess after at least three months; continued use maintains benefit.

Kidney impairment

No renal dose adjustment in the label

Use caution with liver dysfunction; select the strength for the indication.

Before prescribing

Confirm androgenetic alopecia, review mood and sexual symptoms, and discuss effects on PSA testing. The 1-mg hair-loss label is for men; avoid pregnancy exposure.

Side effects and return precautions

Sexual adverse effects can persist after discontinuation in postmarketing reports. Depression and suicidal thoughts are reported. Promptly assess breast lumps/nipple discharge; emergency care for allergic swelling or imminent self-harm. EMA’s 2025 safety advice for the 1-mg hair-loss product is to stop and seek medical advice for mood changes; this is not presented as a new FDA labeling requirement.

Follow-up

Review tolerance and hair photographs at 3–6 months; explain that continued use maintains benefit. Inform clinicians interpreting PSA results.

Sources

Checked September 22, 2026.

Finasteride (Proscar)Enlarged prostate (BPH)

What to say

For your enlarged prostate, take finasteride 5 milligrams once daily, with or without food. It gradually shrinks the prostate and can reduce the chance of urinary retention or surgery. Improvement takes months. If you can’t pass urine, go to urgent or emergency care rather than waiting for this medicine to work.

Reduced sex drive, erection or ejaculation changes, and breast tenderness can occur. Report these, a breast lump, or new depression. Thoughts of self-harm need same-day help. Call 911 if you can’t stay safe. This medicine lowers PSA, so tell anyone ordering that test. Anyone who is pregnant or could be pregnant shouldn’t handle broken or crushed tablets. Skip a missed dose rather than doubling.

Clinical reference

Dose options

BPH with an enlarged prostate

5 mg once daily

Different indication and strength; improvement takes months. Establish a new PSA baseline after at least six months and investigate a confirmed rise.

Kidney impairment

No renal dose adjustment in the label

Use caution with liver dysfunction; select the strength for the indication.

Before prescribing

Confirm prostatic enlargement and evaluate urinary symptoms, retention and prostate-cancer risk. Review PSA, mood, sexual symptoms and hepatic disease; prevent pregnancy exposure.

Side effects and return precautions

Sexual and breast adverse effects, including persistent sexual symptoms reported after discontinuation. Assess mood changes and suicidal thoughts promptly. Inability to void needs urgent care. Any confirmed PSA rise from the on-treatment nadir warrants evaluation.

Follow-up

Review symptoms and adverse effects over 3–6 months. Establish a new PSA baseline after at least six months; double an isolated PSA for comparison with untreated reference ranges and investigate a confirmed rise from nadir.

Sources

Checked September 22, 2026.

Finerenone (Kerendia)Chronic kidney disease with type 2 diabetes

What to say

Finerenone helps protect your kidneys and heart when diabetes has damaged your kidneys; it doesn’t lower blood sugar. Take it once a day, with or without food. You’ll start at 10 or 20 milligrams, depending on your kidney function; the usual goal is 20 milligrams. If you miss a dose, take it the same day, or skip it. We’ll check your potassium and kidney function before starting and 4 weeks after starting or any dose change.

Its main risk is high potassium. Don’t use salt substitutes or potassium supplements unless we approve, and avoid grapefruit and grapefruit juice. Some antibiotics and antifungal medicines raise its level, so check with us before new medicines. Lightheadedness can happen. Call us if you’re vomiting or can’t keep fluids down. Go to the emergency department for marked weakness, a very slow or irregular heartbeat, or fainting.

Clinical reference

Dose options

CKD with type 2 diabetes (albuminuria on maximally tolerated ACEi/ARB)

eGFR ≥60: 20 mg once daily. eGFR 25–<60: 10 mg once daily. Target 20 mg

Don’t start if K+ >5.0 mEq/L or eGFR <25. At 4 weeks: K+ ≤4.8 → raise 10 to 20 mg (stay at 10 mg if eGFR fell >30%); >4.8–5.5 → maintain; >5.5 → withhold, restart 10 mg when K+ ≤5.0.

Heart failure with LVEF ≥40%

Same eGFR-based start; target 40 mg daily if eGFR ≥60 at initiation, 20 mg if 25–<60

K+ 5.5–<6.0: step down one dose (withhold if on 10 mg); K+ ≥6.0: withhold, restart 10 mg when K+ <5.5. Check K+ and eGFR at 4 weeks and after each change.

  • Sept 2026 label also covers HF with LVEF ≥40% and UACR lowering in CKD with type 1 diabetes.

Before prescribing

Before starting: K+ ≤5.0, eGFR ≥25, UACR. Contraindicated with strong CYP3A4 inhibitors (e.g., itraconazole, clarithromycin, ritonavir) and adrenal insufficiency. Avoid strong/moderate CYP3A4 inducers. Review potassium-raising drugs; combination with steroidal MRAs isn’t studied.

Side effects and return precautions

Hyperkalemia (higher with low eGFR, high baseline K+, interacting drugs), hypotension, hyponatremia, early eGFR dip; worsening renal function in HF. Grapefruit raises levels.

Follow-up

K+ and eGFR 4 weeks after starting or any dose change, then periodically; more often with potassium-raising drugs. Continue with ACEi/ARB, SGLT2 inhibitor and statin per KDIGO 2024.

Sources

Checked October 15, 2026.

Fluconazole (Diflucan)Oral candidiasis (thrush)

What to say

For the thrush in your mouth, I’m prescribing fluconazole tablets because [it’s widespread or other treatments haven’t worked]. Take [100 or 200 milligrams] once daily for [7 to 14 days], exactly as written. This is a daily course, not the single-dose yeast-infection treatment. We’ll also address contributing factors such as dentures or inhaled-steroid technique.

Nausea or headache can occur. Call if you aren’t improving, or if swallowing becomes painful or difficult. That may need a different assessment and treatment. Check interactions before starting. Stop and seek urgent care for a blistering rash, yellow skin or eyes, or fainting. Tongue swelling or breathing trouble means call 911.

Clinical reference

Dose options

Moderate/severe oropharyngeal candidiasis

Fluconazole 100–200 mg orally once daily for 7–14 days (IDSA)

Write the chosen dose and duration. Mild disease may be treated topically; esophageal disease and recurrent/refractory thrush need a different plan.

Repeated-dose renal adjustment

Reduce maintenance dose to 50% with CrCl ≤50 mL/min in patients not on dialysis

Follow product-specific loading and dialysis instructions. The single-dose vaginal-infection renal exception does not apply to this course.

Before prescribing

Confirm thrush and assess severity, swallowing symptoms and recurrence. Review immunosuppression/diabetes/HIV testing when appropriate, dentures, inhaled steroids, pregnancy, renal/liver function and major QT/CYP interactions.

Side effects and return precautions

GI symptoms, serious rash, hepatotoxicity and QT-related interactions. Dysphagia/odynophagia or inability to drink needs prompt assessment; do not repeatedly self-treat unexplained recurrent thrush.

Follow-up

Review response during the course; reassess persistent, recurrent or swallowing symptoms. Address denture hygiene, inhaler technique and underlying risks.

Sources

Checked September 23, 2026.

Fluconazole (Diflucan)Recurrent vaginal yeast infection

What to say

Because testing supports repeated Candida albicans yeast infections, we’re using a longer plan: fluconazole 150 milligrams on days one, four and seven, then 150 milligrams once weekly for six months after the initial infection is controlled. We’ll write the dates down. This helps suppress recurrences, but symptoms can return after stopping.

Let’s know if you could be pregnant before taking it. We use a different treatment during pregnancy. Check before starting other medicines because interactions matter. Nausea or headache can happen. Stop and call promptly for yellow skin or eyes, and seek emergency care for a blistering rash or rash with mouth sores. If symptoms persist or return during treatment, contact us for testing rather than taking extra doses.

Clinical reference

Dose options

C. albicans induction in a nonpregnant adult

Fluconazole 100, 150 or 200 mg every third day for three doses (days 1, 4, 7)

The wording above uses 150 mg. Confirm recurrent VVC with testing and assess non-albicans species or resistance.

Suppression after induction

100, 150 or 200 mg weekly for six months

The wording above uses 150 mg. Multiple-dose regimens require renal adjustment; oral fluconazole is not the pregnancy regimen.

Before prescribing

Confirm recurrent VVC (usually ≥3 symptomatic episodes within a year), culture/PCR and Candida species; assess pregnancy, kidney/liver function, QT risk and all interactions. Non-albicans or resistant Candida may need a different regimen and specialist advice.

Side effects and return precautions

Headache/GI upset; serious rash, liver injury, QT interactions. Fever, pelvic pain, sores or atypical discharge needs reassessment of the diagnosis.

Follow-up

Review induction response before suppression, tolerability and interactions during maintenance. Persistent symptoms despite suppression need culture/susceptibility assessment and specialist input; reassess recurrence after the six-month course.

Sources

Checked September 22, 2026.

Fluconazole (Diflucan)Uncomplicated vaginal yeast infection

What to say

For this uncomplicated vaginal yeast infection, take fluconazole 150 milligrams once. That’s one dose, not a daily medicine. It may take a few days for the irritation to settle.

Headache, nausea or stomach discomfort can happen. If symptoms haven’t improved by [date], contact us. Also contact us if they return within two months, rather than repeatedly treating yourself for yeast. Other conditions can feel similar. Tell us before taking it if you could be pregnant or use other prescriptions, because the treatment choice and interactions matter. A blistering rash or rash with mouth sores means stop and go to the emergency department. Trouble breathing or tongue swelling means call 911.

Clinical reference

Dose options

Uncomplicated vulvovaginal candidiasis, nonpregnant adult

150 mg orally once

No renal adjustment needed for this single vaginal-candidiasis dose.

Before prescribing

Confirm diagnosis, pregnancy status, recurrence/complicated features and interactions. Review QT risk, liver disease, warfarin, statins and other interacting drugs.

Side effects and return precautions

Headache/GI upset; serious rash, liver injury, QT interactions. Fever, pelvic pain, sores or atypical discharge needs reassessment of the diagnosis.

Follow-up

No routine follow-up if symptoms resolve. Persistent symptoms or recurrence within two months needs clinical evaluation/testing; repeated episodes warrant culture/speciation and a tailored plan.

Sources

Checked September 22, 2026.

Fluorouracil 5% cream (Efudex)Actinic keratoses

What to say

To clear the rough sun-damage spots on your [area], apply a thin layer of fluorouracil 5% cream twice a day to the whole area we marked. Use a glove, or wash your hands right after. Keep it off your eyelids and out of your eyes, nostrils and mouth. The skin will turn red, crusted and raw; that means it’s working. We’ll stop at the raw stage, usually after 2–4 weeks, and full healing can take 1–2 months.

Avoid sun and tanning beds during treatment. It can kill pets that lick it, so keep the tube and treated skin away from animals, and clean any cream off fabric and furniture. Don’t use it if you’re pregnant or could become pregnant. Call us for severe pain or signs of infection. Stop it and get same-day care for vomiting, bloody diarrhea, severe belly pain or fever.

Clinical reference

Dose options

Actinic keratoses (Efudex 5% cream)

Twice daily to cover the lesions or treated field until the erosion stage, usually 2–4 weeks

Stop at erosion; complete healing may take 1–2 months. Apply with a glove or nonmetal applicator, or wash hands immediately; occlusion intensifies the reaction.

Lower-strength option (face and anterior scalp)

0.5% cream once daily for up to 4 weeks as tolerated, applied 10 minutes after washing and drying

A different product and schedule; don’t transfer the 5% twice-daily instructions.

Before prescribing

Confirm AK clinically; biopsy thick, tender, bleeding or nonresponding lesions. Contraindicated with DPD deficiency, pregnancy or possible pregnancy, or hypersensitivity. Ask about pets, ability to avoid sun, and size of the treated field.

Side effects and return precautions

Expected erythema, vesiculation, erosion, pain and pruritus; eye irritation, allergic contact dermatitis, secondary infection, photosensitivity. Abdominal pain, bloody diarrhea, vomiting or fever suggests DPD-related systemic toxicity: stop and assess urgently.

Follow-up

Review at the peak reaction (2–4 weeks) and 1–2 months after stopping; biopsy lesions that persist. Continue sun protection and periodic skin checks; repeat field treatment as needed.

Sources

Checked October 15, 2026.

Fluoxetine (Prozac)Bulimia nervosa

What to say

For bulimia, fluoxetine can reduce binge-eating and vomiting episodes as part of your eating-disorder treatment. The target is 60 milligrams each morning. We’ll write down how to reach it if a gradual start suits you better. It supports the nutrition and therapy plan. Nausea, sleep changes or sexual side effects can happen. Tell us about continued vomiting, laxative use, dizziness or fainting so we can assess your physical health too.

Call the same day if you feel markedly more agitated, need unusually little sleep, or develop thoughts of harming yourself. If you might act on those thoughts or can’t stay safe, call 911 or go to the emergency department. Stop it and go to the emergency department for fever with confusion, shaking or stiff muscles. We’ll check in within two weeks, sooner if your risk warrants it. Don’t change or stop the dose on your own. Tell us about new medicines, including supplements.

Clinical reference

Dose options

Bulimia nervosa

60 mg orally each morning; may titrate to this dose over several days

The 60-mg dose demonstrated benefit; doses above 60 mg/day were not systematically studied for bulimia.

Older age / hepatic impairment

Consider a lower or less frequent dose

Routine renal reduction generally unnecessary. Long half-life means dose and interaction effects persist for weeks.

Before prescribing

Screen bipolar disorder, suicide risk, interacting serotonergic drugs and pregnancy plans. MAOI washout: ≥14 days before fluoxetine, ≥5 weeks after it. Review CYP2D6 substrates, QT-risk drugs, anticoagulants/NSAIDs and hyponatremia risk. Assess nutritional/medical stability, purging, electrolytes and ECG indications; severe instability requires urgent higher-level care.

Side effects and return precautions

GI upset, activation and sexual effects are common. New suicidality/mania requires prompt contact; imminent self-harm danger or serotonin-syndrome symptoms require emergency care. Plan any discontinuation or switch with its long half-life in mind. Fainting, significant palpitations, severe weakness or inability to maintain intake requires urgent medical assessment.

Follow-up

Review within 2 weeks, or 1 week if aged 18–25 or higher suicide risk; reassess benefit after an adequate trial. Monitor sodium when clinically indicated, especially older adults using diuretics. Track binge/purge frequency and coordinate the eating-disorder care plan. Check electrolytes/ECG according to purging, symptoms and medical risk.

Sources

Checked September 22, 2026.

Fluoxetine (Prozac)Depression

What to say

I’m starting fluoxetine 20 milligrams every morning for depression. Take it daily, with or without food. Improvement builds over several weeks. It’s common not to feel better immediately. Early nausea, looser stools, headache, or feeling more awake may improve with time. Sexual side effects can occur, and I want you to tell me if they bother you.

Call the same day if you feel markedly more agitated, need unusually little sleep, or develop thoughts of harming yourself. If you might act on those thoughts or can’t stay safe, call 911 or go to the emergency department. Stop it and go to the emergency department for fever with confusion, shaking or stiff muscles. We’ll check in within two weeks, sooner if your risk warrants it. Don’t change or stop the dose on your own. Tell us about new medicines, including supplements.

Clinical reference

Dose options

Major depressive disorder

20 mg orally each morning; maximum 80 mg/day

Consider increases after several weeks if needed; 20 mg suffices for many. Daily capsules, not the 90-mg weekly formulation.

Older age / hepatic impairment

Consider a lower or less frequent dose

Routine renal reduction generally unnecessary. Long half-life means dose and interaction effects persist for weeks.

Before prescribing

Screen bipolar disorder, suicide risk, interacting serotonergic drugs and pregnancy plans. MAOI washout: ≥14 days before fluoxetine, ≥5 weeks after it. Review CYP2D6 substrates, QT-risk drugs, anticoagulants/NSAIDs and hyponatremia risk.

Side effects and return precautions

GI upset, activation and sexual effects are common. New suicidality/mania requires prompt contact; imminent self-harm danger or serotonin-syndrome symptoms require emergency care. Plan any discontinuation or switch with its long half-life in mind.

Follow-up

Review within 2 weeks, or 1 week if aged 18–25 or higher suicide risk; reassess benefit after an adequate trial. Monitor sodium when clinically indicated, especially older adults using diuretics.

Sources

Checked September 22, 2026.

Fluoxetine (Prozac)Obsessive-compulsive disorder

What to say

For OCD, start fluoxetine 20 milligrams each morning. The goal is to reduce intrusive thoughts and the time taken by rituals. Improvement may take longer than it does for depression, so we’ll review progress over a full trial while continuing the therapy plan. Nausea, sleep changes or sexual side effects can happen. Tell us about them.

Call the same day if you feel markedly more agitated, need unusually little sleep, or develop thoughts of harming yourself. If you might act on those thoughts or can’t stay safe, call 911 or go to the emergency department. Stop it and go to the emergency department for fever with confusion, shaking or stiff muscles. We’ll check in within two weeks, sooner if your risk warrants it. Don’t change or stop the dose on your own. Tell us about new medicines, including supplements.

Clinical reference

Dose options

Obsessive-compulsive disorder

20 mg daily initially; usual range 20–60 mg/day; maximum 80 mg/day

Increase after several weeks if response is inadequate and tolerated; full benefit may take five weeks or longer.

Older age / hepatic impairment

Consider a lower or less frequent dose

Routine renal reduction generally unnecessary. Long half-life means dose and interaction effects persist for weeks.

Before prescribing

Screen bipolar disorder, suicide risk, interacting serotonergic drugs and pregnancy plans. MAOI washout: ≥14 days before fluoxetine, ≥5 weeks after it. Review CYP2D6 substrates, QT-risk drugs, anticoagulants/NSAIDs and hyponatremia risk.

Side effects and return precautions

GI upset, activation and sexual effects are common. New suicidality/mania requires prompt contact; imminent self-harm danger or serotonin-syndrome symptoms require emergency care. Plan any discontinuation or switch with its long half-life in mind.

Follow-up

Review within 2 weeks, or 1 week if aged 18–25 or higher suicide risk; reassess benefit after an adequate trial. Monitor sodium when clinically indicated, especially older adults using diuretics. Track obsession/compulsion severity and daily function.

Sources

Checked September 22, 2026.

Fluoxetine (Prozac)Panic disorder

What to say

For panic disorder, start fluoxetine 10 milligrams each morning for a week, then 20 milligrams daily if tolerated. This is daily prevention. It won’t stop a panic attack immediately. We’ll work toward fewer attacks and less avoidance over the coming weeks. Nausea, feeling keyed up or changes in sleep can happen early. Tell us if these make treatment difficult.

Call the same day if you feel markedly more agitated, need unusually little sleep, or develop thoughts of harming yourself. If you might act on those thoughts or can’t stay safe, call 911 or go to the emergency department. Stop it and go to the emergency department for fever with confusion, shaking or stiff muscles. We’ll check in within two weeks, sooner if your risk warrants it. Don’t change or stop the dose on your own. Tell us about new medicines, including supplements.

Clinical reference

Dose options

Panic disorder

10 mg daily for one week, then 20 mg daily

Consider further increases only after several weeks if needed; doses above 60 mg/day were not systematically studied for panic disorder.

Older age / hepatic impairment

Consider a lower or less frequent dose

Routine renal reduction generally unnecessary. Long half-life means dose and interaction effects persist for weeks.

Before prescribing

Screen bipolar disorder, suicide risk, interacting serotonergic drugs and pregnancy plans. MAOI washout: ≥14 days before fluoxetine, ≥5 weeks after it. Review CYP2D6 substrates, QT-risk drugs, anticoagulants/NSAIDs and hyponatremia risk.

Side effects and return precautions

GI upset, activation and sexual effects are common. New suicidality/mania requires prompt contact; imminent self-harm danger or serotonin-syndrome symptoms require emergency care. Plan any discontinuation or switch with its long half-life in mind.

Follow-up

Review within 2 weeks, or 1 week if aged 18–25 or higher suicide risk; reassess benefit after an adequate trial. Monitor sodium when clinically indicated, especially older adults using diuretics. Track panic attacks and avoidance.

Sources

Checked September 22, 2026.

Fluoxetine tablets (Sarafem)Premenstrual dysphoric disorder (PMDD), daily dosing

What to say

For PMDD, take fluoxetine 20 milligrams each morning, every day throughout the month. We’ll put the dates in writing and use a daily symptom record to see whether it reduces the severe mood symptoms around your period. Tell us if depression or anxiety also persists during the rest of the month.

Nausea, headache, sleep changes or sexual side effects can occur. Contact us promptly for marked agitation, unusually high energy with very little sleep or new self-harm thoughts. If you can’t stay safe, call 911. Check before adding other mood medicines or supplements. Fluoxetine remains in the body for weeks after stopping.

Clinical reference

Dose options

PMDD-labeled daily fluoxetine tablets

20 mg daily throughout the menstrual cycle

This is the PMDD tablet regimen associated with Sarafem/generic fluoxetine tablets, not the weekly delayed-release depression capsule. Do not use the depression maximum as a PMDD target.

Hepatic impairment

Use a lower or less frequent dose when indicated

Review long half-life and interactions; allow at least five weeks after fluoxetine before an MAOI.

Before prescribing

Confirm cyclic PMDD using prospective symptom records where feasible, and distinguish premenstrual worsening of another condition. Review bipolar/suicide risk, liver disease, pregnancy plans, MAOIs, serotonergic/QT interactions and bleeding or hyponatremia risks.

Side effects and return precautions

GI upset, activation and sexual effects are common. New suicidality/mania requires prompt contact; imminent self-harm danger or serotonin-syndrome symptoms require emergency care. Plan any discontinuation or switch with its long half-life in mind.

Follow-up

Early safety/tolerance review, then assess daily symptom records over the first few cycles. Reconfirm the calendar for intermittent use. Do not independently change the schedule or switch serotonergic medicines.

Sources

Checked September 23, 2026.

Fluoxetine tablets (Sarafem)Premenstrual dysphoric disorder (PMDD), luteal-phase dosing

What to say

For PMDD, take fluoxetine 20 milligrams each morning, starting 14 days before the expected period and continuing through the first full day of bleeding, then stop until the next planned cycle. We’ll put the dates in writing and use a daily symptom record to see whether it reduces the severe mood symptoms around your period. Tell us if depression or anxiety also persists during the rest of the month.

Nausea, headache, sleep changes or sexual side effects can occur. Contact us promptly for marked agitation, unusually high energy with very little sleep or new self-harm thoughts. If you can’t stay safe, call 911. Check before adding other mood medicines or supplements. Fluoxetine remains in the body for weeks after stopping.

Clinical reference

Dose options

PMDD-labeled daily fluoxetine tablets

20 mg daily from 14 days before expected menses through the first full day of menses

This is the PMDD tablet regimen associated with Sarafem/generic fluoxetine tablets, not the weekly delayed-release depression capsule. Do not use the depression maximum as a PMDD target.

Hepatic impairment

Use a lower or less frequent dose when indicated

Review long half-life and interactions; allow at least five weeks after fluoxetine before an MAOI.

Before prescribing

Confirm cyclic PMDD using prospective symptom records where feasible, and distinguish premenstrual worsening of another condition. Review bipolar/suicide risk, liver disease, pregnancy plans, MAOIs, serotonergic/QT interactions and bleeding or hyponatremia risks.

Side effects and return precautions

GI upset, activation and sexual effects are common. New suicidality/mania requires prompt contact; imminent self-harm danger or serotonin-syndrome symptoms require emergency care. Plan any discontinuation or switch with its long half-life in mind.

Follow-up

Early safety/tolerance review, then assess daily symptom records over the first few cycles. Reconfirm the calendar for intermittent use. Do not independently change the schedule or switch serotonergic medicines.

Sources

Checked September 23, 2026.

Fluticasone furoate/umeclidinium/vilanterol (Trelegy Ellipta)COPD

What to say

Trelegy combines an inhaled steroid with two long-acting medicines that open your airways. For COPD with flare-ups, it eases breathing and helps prevent more flare-ups. Take one inhalation once a day at the same time, then rinse your mouth with water and spit. Let’s practice the technique. If you miss a dose, take it when you remember, but never twice in one day. It won’t relieve sudden symptoms, so keep your rescue inhaler with you.

Hoarseness, thrush (white patches or soreness in the mouth) or headache can happen. It raises the chance of pneumonia, so call the same day for fever, chills, more or discolored mucus, or worse breathing. Go to the emergency department for eye pain with blurred vision or halos, or if you can’t pass urine. If a dose makes breathing suddenly worse, use your rescue inhaler, stop Trelegy and call us. Severe breathlessness or trouble speaking means call 911. Don’t use other long-acting inhalers with it.

Clinical reference

Dose options

COPD maintenance

100/62.5/25 mcg: 1 inhalation once daily at the same time each day

The only COPD strength; never more than 1 inhalation/24 h and not for rescue. No renal, geriatric or moderate hepatic adjustment; use caution in moderate–severe hepatic impairment (fluticasone furoate exposure rises). Discard 6 weeks after opening the tray.

GOLD 2026 place in therapy

Escalate from LABA+LAMA after a moderate or severe exacerbation (benefit seen at eosinophils ≥100 cells/µL, larger at higher counts); consider as initial group E therapy if eosinophils ≥300

The label covers COPD maintenance without exacerbation or eosinophil criteria; GOLD reserves ICS-containing triple therapy for exacerbation risk. LABA+ICS alone is not encouraged. Eosinophils <100 with exacerbations on LABA+LAMA: consider azithromycin (if not smoking) or roflumilast (FEV1 <50%, chronic bronchitis, prior hospitalization).

Asthma (adults 18 and older)

100/62.5/25 or 200/62.5/25 mcg: 1 inhalation once daily

Separate asthma indication; the 200 strength is not for COPD. COPD with concomitant asthma is treated as asthma, with an ICS.

  • GOLD 2026 places patients with even one moderate exacerbation in the past year in group E and uses that threshold to consider escalation.

Before prescribing

Confirm spirometry-defined COPD, exacerbation history and blood eosinophils. Check severe milk-protein allergy, narrow-angle glaucoma, urinary retention/BPH, arrhythmia, osteoporosis risk, strong CYP3A4 inhibitors (ritonavir, clarithromycin, itraconazole), beta-blockers, MAOIs/TCAs/QT drugs and duplicate LABA/LAMA/ICS inhalers. Prescribe a SABA.

Side effects and return precautions

Oral candidiasis, dysphonia, pneumonia (overlaps with exacerbation), paradoxical bronchospasm, tachyarrhythmia, hypokalemia/hyperglycemia, angle-closure glaucoma, urinary retention. Label advises baseline and periodic BMD assessment in COPD.

Follow-up

Review technique, adherence, rescue use and exacerbations within 1–3 months; give a written exacerbation plan. Withdraw ICS only if inappropriate, ineffective, or causing significant side effects or recurrent pneumonia; exacerbations are likelier after withdrawal if eosinophils ≥300.

Sources

Checked October 15, 2026.

Fluticasone nasal spray (Flonase)Allergic rhinitis

What to say

Start two sprays in each nostril once a day. This is fluticasone propionate, a nasal steroid that treats the swelling causing allergy symptoms. It works best with regular use over several days, rather than as an instant decongestant.

Gently blow your nose first, tilt your head slightly forward and aim the nozzle toward the outer wall of the nostril, away from the middle divider. Sniff gently. Dryness or nosebleeds can happen, so tell me if bleeding keeps recurring or the nose feels sore. Once symptoms are controlled, we can reduce to one spray in each nostril daily. Let me know about vision changes, recent nasal surgery or other steroid medicines, and check with the pharmacist about priming and cleaning this particular bottle.

Clinical reference

Dose options

Start

2 sprays per nostril once daily (200 mcg/day)

Fluticasone propionate 50 mcg/spray; alternatively one spray/nostril twice daily.

Maintenance / maximum

Reduce to 1 spray/nostril daily once controlled; maximum 200 mcg/day

Do not transpose to fluticasone furoate, Xhance or a lung inhaler.

Before prescribing

Check nasal injury/surgery, glaucoma/cataracts, other steroid exposure and strong CYP3A4 inhibitors including ritonavir/cobicistat. Demonstrate direction away from the septum.

Side effects and return precautions

Dryness, irritation, epistaxis. Recurrent/heavy bleeding, persistent sores or visual symptoms requires review; sudden vision loss or severe eye pain needs immediate assessment.

Follow-up

Review response and technique after regular use, often within a few weeks. Reduce to the lowest effective schedule; investigate persistent unilateral or atypical symptoms.

Sources

Checked September 20, 2026.

Fluticasone propionate HFA (Flovent HFA)Asthma, daily controller

What to say

This inhaled steroid calms the airway swelling that leads to asthma attacks. Use two puffs of the 44-microgram inhaler twice a day, every day, even when you feel well. Full benefit can take one to two weeks or longer. Shake it before each puff and use a spacer. Before first use, spray four test puffs into the air. Rinse your mouth with water and spit after each dose. If you miss a dose, skip it.

It won’t relieve sudden symptoms, so keep your quick-relief inhaler with you. Hoarseness or thrush (white patches or soreness in the mouth) can happen. Call us if you need your quick-relief inhaler more than usual, it isn’t working as well, or you need four or more puffs a day for two days in a row. Severe breathlessness, trouble speaking or blue lips means call 911. Tell us before starting antifungal or HIV medicines, which can raise steroid levels.

Clinical reference

Dose options

Adult low dose (GINA Track 2, Step 2)

44 mcg/actuation: 2 puffs (88 mcg) twice daily

Labeled starting dose without prior ICS. GINA 2026 pairs daily ICS with as-needed albuterol/budesonide where available, otherwise albuterol; the label names a SABA. GINA prefers Track 1 ICS-formoterol when possible.

Medium and high doses

110 mcg: 2 puffs twice daily (medium); 220 mcg: 2 puffs twice daily (high); label maximum 880 mcg twice daily

Check technique, adherence and triggers first; ICS-LABA usually beats higher-dose ICS alone. GINA lists metered doses: 44/110/220 mcg delivered = 50/125/250 mcg metered.

Device

Prime with 4 sprays before first use; 1 spray if unused >7 days or dropped; discard at counter 000

Use with a spacer or valved holding chamber; GINA advises spacers for ICS by pMDI.

  • Brand Flovent HFA was discontinued at the end of 2023; prescribe generic fluticasone propionate HFA (authorized generic and other generics), which uses the same strengths.

Before prescribing

Confirm asthma and the GINA track and reliever (Track 1 ICS-formoterol preferred). Check technique, spacer, adherence, strong CYP3A4 inhibitors (ritonavir, itraconazole, clarithromycin), recent systemic steroids, TB or ocular herpes, and bone and eye risk.

Side effects and return precautions

Oral candidiasis, dysphonia, URI symptoms. Systemic steroid effects or adrenal suppression with high doses or CYP3A4 inhibitors; infections may worsen. Long term: BMD loss, glaucoma, cataract. Rising reliever use signals poor control.

Follow-up

Review symptoms, reliever use, exacerbations and technique 1–3 months after starting, then every 3–12 months, and within 1 week after an exacerbation. Step down after 2–3 months of good control; don’t stop ICS completely.

Sources

Checked October 15, 2026.

Fluticasone/salmeterol (Advair Diskus)Asthma

What to say

For your asthma, use one inhalation of Advair Diskus 100/50 twice a day, about twelve hours apart. The two numbers are the strengths of the steroid and the long-acting airway medicine. Use it every day to prevent symptoms. For sudden symptoms, use the separate rescue inhaler in your written plan. Don’t take extra Diskus doses.

Let’s practice loading a dose and breathing it in through the mouth. Keep the device dry and don’t attach a spacer. Rinse your mouth and spit afterward. Hoarseness, throat irritation or white patches in the mouth can occur. Tell us if they develop. If breathing gets worse immediately after a dose, stop that inhaler and follow your urgent breathing plan. Severe breathlessness or trouble speaking means call 911. We’ll check your technique, symptoms and rescue use in about a month.

Clinical reference

Dose options

Adult asthma: Diskus

1 inhalation of 100/50, 250/50 or 500/50 twice daily

Select strength from prior therapy and severity; maximum 500/50, one inhalation twice daily.

Product boundary

These doses apply to Advair Diskus

HFA, AirDuo and other devices have different strengths/instructions. Salmeterol combinations are not SMART/MART rescue inhalers.

Before prescribing

Check severe milk-protein allergy, duplicate LABA, inhalation ability, CYP3A4 interactions and steroid exposure. Assess whether ICS/LABA is the appropriate asthma or COPD strategy.

Side effects and return precautions

Thrush and dysphonia; paradoxical bronchospasm requires stopping and urgent treatment. Monitor pneumonia symptoms particularly in COPD.

Follow-up

Review device technique and symptoms after the change, with earlier contact for increased rescue use. Supply a separate rescue plan and sufficient refills.

Sources

Checked September 22, 2026.

Fluticasone/salmeterol (Advair Diskus)COPD

What to say

For your COPD, use one inhalation of Advair Diskus 250/50 twice daily, about twelve hours apart. Use it every day as part of the plan to control symptoms and reduce flare-ups. For sudden symptoms use your separate rescue medicine. Don’t take extra Diskus doses.

Let’s practice loading a dose and breathing it in through the mouth. Keep the device dry and don’t attach a spacer. Rinse your mouth and spit afterward. Hoarseness, throat irritation or white patches in the mouth can occur. Tell us if they develop. If breathing gets worse immediately after a dose, stop that inhaler and follow your urgent breathing plan. Severe breathlessness or trouble speaking means call 911. We’ll check your technique, symptoms and rescue use in about a month.

Clinical reference

Dose options

COPD: Diskus

250/50, one inhalation twice daily

The 250/50 strength is the labeled COPD regimen.

Product boundary

These doses apply to Advair Diskus

HFA, AirDuo and other devices have different strengths/instructions. Salmeterol combinations are not SMART/MART rescue inhalers.

Before prescribing

Check severe milk-protein allergy, duplicate LABA, inhalation ability, CYP3A4 interactions and steroid exposure. Assess whether ICS/LABA is the appropriate asthma or COPD strategy.

Side effects and return precautions

Thrush and dysphonia; review increased pneumonia risk with ICS in COPD and assess new fever, changed sputum or worsening breathlessness. Paradoxical bronchospasm requires stopping the inhaler and urgent treatment.

Follow-up

Review device technique and symptoms after the change, with earlier contact for increased rescue use. Supply a separate rescue plan and sufficient refills.

Sources

Checked September 22, 2026.

Fosfomycin (Monurol)Uncomplicated cystitis

What to say

This is a one-time antibiotic dose for a bladder infection. Pour the whole packet into half a cup of water, not hot water, stir until it dissolves, and drink it right away. Don’t swallow the granules dry. You can take it with or without food. You only need this single dose, and your symptoms should start improving within two to three days.

Diarrhea, nausea, headache and vaginal irritation are the most common side effects. Call us if you aren’t improving after three days. Fever, side or back pain, or vomiting can mean a kidney infection: call the same day, or go to the emergency department if you feel very ill or can’t keep fluids down. Watery or bloody diarrhea, even weeks later, also needs a same-day call. Trouble breathing or swelling of the face or throat means call 911. Tell us if you could be pregnant. If we sent a culture, we’ll tell you whether you need a different medicine.

Clinical reference

Dose options

Uncomplicated cystitis, nonpregnant women 18 and older

Fosfomycin tromethamine 3 g (1 sachet) orally once, dissolved in 3–4 oz (½ cup) of water

Don’t give a second dose for the same episode; repeat daily doses didn’t improve cure and increased adverse events. IDSA: an appropriate choice, but it appears less effective than standard short-course regimens.

Not appropriate for

Pyelonephritis, perinephric abscess or systemic infection

Men, pregnancy and complicated UTI need their own assessment and regimen.

  • The Monurol brand is discontinued in the US; generic fosfomycin tromethamine 3 g sachets are available.

Before prescribing

Confirm lower-tract symptoms without fever, flank pain or systemic illness. Useful with resistance, allergy or intolerance of other first-line agents; send culture with recurrence, prior resistant organisms or atypical features. Review pregnancy and metoclopramide (lowers fosfomycin levels).

Side effects and return precautions

Diarrhea (about 9%), nausea, headache, vaginitis; C. difficile can occur up to 2 months later. Rare angioedema, hepatic injury or optic neuritis. Fever or flank pain suggests upper-tract infection.

Follow-up

Reassess if symptoms aren’t improving in 2–3 days or recur, and act on any culture. If bacteriuria persists or returns, choose a different agent rather than repeating fosfomycin.

Sources

Checked October 15, 2026.

Furosemide (Lasix)Edema

What to say

Furosemide helps your body get rid of extra fluid. Start 20 milligrams each morning for the swelling we’ve assessed. You’ll usually notice more urination, so plan bathroom access. Follow the fluid and salt plan we discussed.

Weigh yourself each morning under similar conditions and record the result. I’ll write down the weight changes and symptoms that should prompt a call. Don’t take extra tablets unless they’re part of our plan. Call the same day for marked dizziness, weakness, cramps with a racing or irregular heartbeat, much less urine, or vomiting or diarrhea that prevents drinking. Severe breathlessness, fainting or chest pain means call 911. We’ll check kidney function and blood salts such as sodium and potassium in one to two weeks, sooner if your risk calls for it.

Clinical reference

Dose options

Adult edema start

20–80 mg orally once, chosen by severity and prior diuretic exposure

The wording above uses 20 mg. Dose and frequency then depend on response and renal function.

Dose adjustment

Label permits 20–40 mg increments no sooner than 6–8 hours after a prior dose

Outpatient adjustments need an explicit clinician plan; a second daily dose is usually scheduled early enough to limit nocturia.

High doses / contraindication

Severe edema may require specialist-directed higher doses; label describes up to 600 mg/day

Not a routine outpatient target. Contraindicated in anuria; advanced kidney disease may require higher rather than lower doses with closer monitoring.

Before prescribing

Confirm volume overload rather than unexplained edema; review BP, weights, sodium/potassium/magnesium and renal function. Review NSAIDs, lithium, other diuretics, orthostasis and urinary obstruction.

Side effects and return precautions

Volume depletion, low electrolytes, kidney dysfunction, gout and rare hearing effects. Define sick-day and weight-trigger actions; do not give a universal fluid-increase instruction.

Follow-up

Practical BP/renal/electrolyte check in 1–2 weeks after initiation/change, often 5–7 days in high-risk patients. Earlier symptom/weight contact for active congestion; adjust to clinical course.

Sources

Checked September 20, 2026.

G–N

Gabapentin (Neurontin)Alcohol use disorder, off-label

What to say

To help you cut back or stop drinking, we’re using gabapentin off-label. It may help you drink less and sleep better. Take 300 milligrams at bedtime on day 1, then add 300 milligrams a day as tolerated, up to 600 milligrams three times a day. Take it every day, and keep using your recovery supports. If you get shaky or sweaty after cutting back, get same-day care; for confusion, seeing things or a seizure, call 911.

Sleepiness, dizziness and unsteadiness are common. Don’t drive until you know how it affects you. Mixing it with alcohol, opioids or other sedatives can dangerously slow breathing; call 911 if someone is hard to wake or breathing slowly. Take only the prescribed amount, keep it secure, and don’t share it. Call the same day for new or worsening thoughts of self-harm. If you might act on those thoughts, call 911. Don’t stop suddenly; we’ll lower it gradually.

Clinical reference

Dose options

Moderate–severe AUD (off-label)

300 mg at bedtime on day 1; increase by 300 mg/day as tolerated to 600 mg three times daily (1,800 mg/day)

VA/DoD 2021 dosing. Stop and consider alternatives if there’s no benefit after ≥900 mg/day for 2–3 months.

Renal adjustment

CrCl >30–59: 400–1,400 mg/day in 2 doses; >15–29: 200–700 mg/day once; 15: 100–300 mg/day

Label totals; reduce further below 15 and plan dialysis dosing separately. VA/DoD: consider a target <1,800 mg/day when CrCl <60.

  • Off-label. APA 2018 suggests gabapentin or topiramate for moderate–severe AUD when patients prefer them or naltrexone and acamprosate are unsuitable or ineffective; VA/DoD 2021 suggests it as second line.

Before prescribing

Confirm moderate–severe AUD and consider naltrexone or acamprosate first. Check CrCl, opioid or other sedative use, respiratory disease, misuse history, suicidality, pregnancy and withdrawal risk; gabapentin doesn’t replace withdrawal management.

Side effects and return precautions

Sedation, dizziness, ataxia, edema; respiratory depression with opioids, alcohol or other CNS depressants; misuse; suicidality; DRESS. Give ≥2 hours after aluminum/magnesium antacids.

Follow-up

Review sedation and drinking within 1–2 weeks during titration. Track drinking goals; stop if no benefit at ≥900 mg/day after 2–3 months. Taper over ≥1 week when stopping.

Sources

Checked October 15, 2026.

Gabapentin (Neurontin)Diabetic nerve pain, off-label

What to say

Gabapentin may reduce the burning or shooting pain from diabetes. This is an off-label use supported by treatment guidance. For this trial, start 300 milligrams at night. We’ll increase gradually using your written schedule if you’re tolerating it. It treats pain, not the underlying nerve damage, so keep up foot checks and your diabetes care.

Sleepiness, dizziness and ankle swelling can occur. Avoid driving until you know its effect, and check before combining it with alcohol, opioids or other sedatives. Call 911 for slow breathing or difficulty waking. Contact us promptly for new thoughts of self-harm. Immediate danger means call 911. If it isn’t helping, we’ll plan a gradual reduction rather than stopping suddenly.

Clinical reference

Dose options

Adult starting trial

300 mg at night, then gradual clinician-directed titration toward divided daily doses

Lower/slower initiation for frailty or renal impairment. Effective doses often require 1,800–3,600 mg/day in divided doses with normal renal function; do not escalate without assessing benefit and sedation.

Renal function and formulation

Adjust dose and frequency to creatinine clearance before starting or increasing

Use immediate-release gabapentin. Neurontin, Gralise and gabapentin enacarbil (Horizant) do not share interchangeable schedules; dialysis requires a separate dosing plan.

Before prescribing

Check renal function, indication, falls, respiratory disease, opioids/benzodiazepines/other sedatives and substance-use concerns. Discuss measurable benefit and the planned trial duration.

Side effects and return precautions

Dizziness, sedation, ataxia, edema; respiratory depression with risk factors, suicidality and serious allergic/multisystem reactions. Separate aluminum/magnesium antacid from gabapentin by at least two hours, taking gabapentin afterward.

Follow-up

Review in 1–2 weeks during titration. Track pain interference, sleep and activity; switch strategy if a tolerated trial does not provide meaningful benefit. Continue diabetic foot care. Taper over at least one week, often longer.

Sources

Checked September 23, 2026.

Gabapentin (Neurontin)Focal seizures, add-on treatment

What to say

Gabapentin is being added to your existing treatment to reduce focal seizures. Keep taking your other seizure medicines. Follow the dose and times on the written neurology plan. The usual immediate-release schedule is three times daily. Keep a seizure record and contact us before you run out. Don’t stop or change it suddenly.

Sleepiness, dizziness or unsteadiness can occur. Avoid alcohol and check before taking opioids or other sedatives. Don’t drive until your epilepsy team confirms it’s safe and permitted. Call promptly for mood changes or thoughts of self-harm. Immediate danger means call 911. Slow breathing or difficulty waking also needs 911. Stop it and seek emergency care for swelling of the mouth or throat. Report fever with rash or swollen glands urgently.

Follow your seizure action plan. Call 911 for a seizure lasting more than five minutes, repeated seizures without recovery, or trouble breathing or waking afterward.

Clinical reference

Dose options

Adult adjunctive focal-seizure treatment, normal renal function

Label start: 300 mg three times daily; usual maintenance 300–600 mg three times daily

On the standard three-times-daily schedule, avoid gaps over 12 hours. Individualize the starting plan; this differs from the shingles-pain titration.

Renal impairment or discontinuation

Adjust dose and frequency using the label’s creatinine-clearance table; dialysis needs supplemental dosing

Neurology should coordinate any withdrawal or substitution. Taper over at least one week, often longer; do not abruptly stop regular therapy.

Before prescribing

Confirm focal seizure diagnosis, current antiseizure regimen, renal function, pregnancy plans, sedatives and respiratory risk. Reconcile the immediate-release formulation and written titration/rescue plans.

Side effects and return precautions

Sedation, impaired coordination, edema, respiratory depression and serious hypersensitivity. Take gabapentin at least two hours after aluminum/magnesium antacids. Monitor mood and seizure frequency.

Follow-up

Arrange early review during titration with the epilepsy team; assess seizures, adherence, falls and renal dosing. New or worsening seizures need prompt contact rather than self-titration.

Sources

Checked September 23, 2026.

Gabapentin (Neurontin)Menopausal hot flashes, off-label

What to say

Gabapentin is a nonhormonal option for hot flashes and night sweats. This is an off-label use. Start 300 milligrams at bedtime. If needed and tolerated, we’ll add daytime doses gradually using the written plan. We’ll judge it by how often symptoms occur and how much they disrupt sleep and daily life.

Sleepiness, dizziness and ankle swelling can occur. Avoid driving until you know its effect, and check before combining it with alcohol, opioids or other sedatives. Call 911 for slow breathing or difficulty waking. Contact us promptly for new thoughts of self-harm. Immediate danger means call 911. If it isn’t helping, we’ll plan a gradual reduction rather than stopping suddenly.

Clinical reference

Dose options

Starting plan

300 mg at bedtime; add daytime doses gradually toward 300 mg three times daily if needed and tolerated

Menopause guidance describes 900–2,400 mg/day in divided doses; use a lower start for frailty and adjust for renal function. Do not assume a bedtime starting dose is the final effective dose.

Renal function and formulation

Adjust dose and frequency to creatinine clearance before starting or increasing

Use immediate-release gabapentin. Neurontin, Gralise and gabapentin enacarbil (Horizant) do not share interchangeable schedules; dialysis requires a separate dosing plan.

Before prescribing

Confirm vasomotor symptoms and discuss hormonal and nonhormonal options. Check kidney function, falls, respiratory disease, sedatives, mood and pregnancy possibility.

Side effects and return precautions

Dizziness, sedation, ataxia, edema; respiratory depression with risk factors, suicidality and serious allergic/multisystem reactions. Separate aluminum/magnesium antacid from gabapentin by at least two hours, taking gabapentin afterward.

Follow-up

Review hot-flash frequency, sleep and sedation in 2–4 weeks. Continue only with meaningful benefit; taper planned discontinuation.

Sources

Checked September 23, 2026.

Gabapentin (Neurontin)Pain after shingles

What to say

For the nerve pain after shingles, start gabapentin 300 milligrams at bedtime on day one, 300 milligrams twice a day on day two, then 300 milligrams three times a day on day three if you’re tolerating it. We can go more slowly if it makes you sleepy or dizzy. This is the immediate-release form.

The aim is less pain and better sleep or function. It may not remove all pain. Sleepiness, dizziness or ankle swelling can happen. Don’t drive until you know its effect, and avoid alcohol or other sedating medicines unless we’ve reviewed the combination. Slow or shallow breathing or difficulty waking means call 911. Call the same day for new suicidal thoughts. Immediate danger means 911. We’ll check in within one to two weeks and adjust from benefit and side effects. Don’t stop suddenly after regular use.

Clinical reference

Dose options

Postherpetic neuralgia, immediate release

Day 1: 300 mg once; day 2: 300 mg twice; day 3: 300 mg three times daily

May start lower/slower in older/frail patients. Titrate as needed toward 1,800 mg/day divided; no added PHN benefit above 1,800 mg/day was demonstrated in the cited label.

Renal adjustment

CrCl >30–59: total 400–1,400 mg/day divided twice daily; >15–29: 200–700 mg once daily

CrCl 15: 100–300 mg/day, proportionally less below 15. Hemodialysis requires supplemental dosing. Do not use the standard titration without renal review.

Before prescribing

Check renal function, indication, falls, respiratory disease, opioids/benzodiazepines/other sedatives and substance-use concerns. Discuss measurable benefit and the planned trial duration.

Side effects and return precautions

Dizziness, sedation, ataxia, edema; respiratory depression with risk factors, suicidality and serious allergic/multisystem reactions. Separate aluminum/magnesium antacid from gabapentin by at least two hours, taking gabapentin afterward.

Follow-up

Review within 1–2 weeks during titration and assess function/pain after a defined trial. If stopping, taper over at least one week, often longer according to dose/duration and clinical context.

Sources

Checked September 23, 2026.

Gabapentin (Neurontin)Restless legs syndrome, off-label

What to say

For restless legs, we’re trying immediate-release gabapentin off-label to reduce the evening urge to move your legs. Start 300 milligrams about one to two hours before symptoms usually begin. We may choose a lower starting dose based on your age or kidney function. We’ll adjust from your symptoms and next-day alertness.

We’ll also check iron levels and address medicines or sleep problems that can make restless legs worse. Sleepiness, dizziness and ankle swelling can occur. Avoid driving until you know its effect, and check before combining it with alcohol, opioids or other sedatives. Call 911 for slow breathing or difficulty waking. Contact us promptly for new thoughts of self-harm. Immediate danger means call 911. If it isn’t helping, we’ll plan a gradual reduction rather than stopping suddenly.

Clinical reference

Dose options

Evening starting dose

300 mg 1–2 hours before usual symptom onset; consider 100 mg in adults older than 65

Increase every few days only under the written plan. Dose timing follows symptoms; larger daily amounts may need divided dosing because absorption is limited.

Renal function and formulation

Adjust dose and frequency to creatinine clearance before starting or increasing

Use immediate-release gabapentin. Neurontin, Gralise and gabapentin enacarbil (Horizant) do not share interchangeable schedules; dialysis requires a separate dosing plan.

Before prescribing

Confirm RLS rather than cramps or neuropathy. Check ferritin and transferrin saturation, renal function, pregnancy, untreated sleep apnea, falls, respiratory disease, sedatives and misuse risk. Address aggravating medicines and iron deficiency.

Side effects and return precautions

Dizziness, sedation, ataxia, edema; respiratory depression with risk factors, suicidality and serious allergic/multisystem reactions. Separate aluminum/magnesium antacid from gabapentin by at least two hours, taking gabapentin afterward.

Follow-up

Review evening symptoms, sleep and next-day sedation in 1–2 weeks. Treat iron deficiency using the RLS-specific plan; do not use escalating medication as a substitute. Taper planned discontinuation.

Sources

Checked September 23, 2026.

Gemfibrozil (Lopid)Severe hypertriglyceridemia

What to say

Gemfibrozil lowers triglycerides, a type of fat in your blood. Take one 600-milligram tablet twice a day, thirty minutes before breakfast and your evening meal. Keep following the food, activity and alcohol plan we discussed. The medicine works alongside those changes.

Stomach upset can happen. Call promptly for unexplained muscle pain or weakness, especially with dark urine, or for severe upper abdominal pain or yellowing of the eyes. Check with us before starting another cholesterol medicine or changing any prescription. We’ll repeat blood tests on [date] to see whether it’s working and check for side effects.

Clinical reference

Dose options

Adult regimen

600 mg orally twice daily, 30 minutes before morning and evening meals

Total 1,200 mg/day; do not use with hepatic or severe renal dysfunction or preexisting gallbladder disease.

Before prescribing

Confirm fasting lipids, secondary causes, kidney/liver function, gallbladder history and pregnancy/breastfeeding. Simvastatin, repaglinide, dasabuvir and selexipag combinations are contraindicated. Other statins also increase myopathy risk; review alternatives. Warfarin requires closer INR monitoring and possible dose adjustment.

Side effects and return precautions

GI upset, gallstones, liver abnormalities and myopathy/rhabdomyolysis. Muscle symptoms warrant prompt assessment, particularly with interacting drugs.

Follow-up

Arrange periodic lipids and liver tests; consider renal function and CBC monitoring according to risk and labeling. Stop if lipid response remains inadequate after 3 months. Persistent abnormal liver tests require discontinuation.

Sources

Checked September 24, 2026.

Glecaprevir/pibrentasvir (Mavyret)Hepatitis C

What to say

Mavyret cures hepatitis C in most people who finish it. Take all three tablets together once a day with food for eight weeks. If you’re less than 18 hours late for a dose, take it with food right away; if it’s more than 18 hours, skip it. A blood test 12 weeks after you finish will confirm whether the virus is gone.

Headache, tiredness and nausea are common. Rifampin, some HIV and seizure medicines, St John’s wort and some cholesterol medicines don’t mix with Mavyret, so check with us before starting anything new. Birth control with more than 20 micrograms of estrogen isn’t recommended; we can adjust your method. If you take diabetes medicine or warfarin, check your sugar or INR more often. Tell us if you’re pregnant. Call the same day for yellow eyes, dark urine, belly swelling or confusion. Vomiting blood or black stools means go to the emergency department. Cure doesn’t prevent a new infection.

Clinical reference

Dose options

Chronic HCV, treatment-naive adults

3 tablets (each glecaprevir 100 mg/pibrentasvir 40 mg) orally once daily with food for 8 weeks

Same course with no cirrhosis or compensated cirrhosis (Child-Pugh A), any genotype (AASLD/IDSA simplified treatment). No renal adjustment, including dialysis. Treatment-experienced and transplant patients need different durations.

Missed dose

Less than 18 hours late: take with food as soon as possible. More than 18 hours: skip and resume at the usual time

Per the prescribing information.

Interactions to plan around

Contraindicated: atazanavir, rifampin. Not recommended: atorvastatin, lovastatin, simvastatin, carbamazepine, efavirenz, darunavir, lopinavir, ritonavir, St John’s wort, ethinyl estradiol >20 mcg

Rosuvastatin ≤10 mg; halve pravastatin. The current label permits ethinyl estradiol ≤20 mcg and progestin-only methods. Measure digoxin and reduce the dose by about 50%.

Before prescribing

Confirm HCV RNA, treatment history and cirrhosis status. Contraindicated with Child-Pugh B or C, any prior decompensation, atazanavir or rifampin. Test HBsAg and anti-HBc (boxed warning), HIV and pregnancy; review statins, contraception, anticonvulsants and HIV regimen.

Side effects and return precautions

Headache, fatigue, nausea. Hepatic decompensation or failure (jaundice, ascites, encephalopathy, variceal bleeding), typically within 4 weeks and mostly with advanced disease: stop the drug. HBV reactivation; hypoglycemia and INR changes as HCV clears.

Follow-up

HCV RNA and hepatic panel 12 or more weeks after completion. With compensated cirrhosis or portal hypertension, check hepatic labs as indicated during treatment and continue HCC ultrasound every 6 months after cure. Ongoing risk: yearly HCV RNA.

Sources

Checked October 15, 2026.

Glipizide ER (Glucotrol XL)Type 2 diabetes

What to say

For your type 2 diabetes, take glipizide extended release 5 milligrams with breakfast or your first main meal each day. Swallow it whole. It helps your pancreas release insulin, so low blood sugar can happen, especially if you skip food. If you can’t eat, hold that day’s dose and call us for a sick-day and restart plan. Check glucose each morning and whenever you feel shaky, sweaty or unusually hungry.

For a reading below 70 mg/dL, if you can swallow safely, take 15 grams of fast sugar, such as glucose tablets or gel totaling 15 grams according to the package and recheck after 15 minutes. Repeat if still low. Severe confusion, seizure or inability to swallow means a helper should use glucagon if available and call 911, with nothing by mouth. Call us the same day after a low because it can recur. Some weight gain is possible. We’ll review readings in one to two weeks and your A1c in about three months.

Clinical reference

Dose options

Usual adult ER start

5 mg orally once daily with breakfast or the first main meal

Swallow intact. Do not substitute immediate-release schedules.

Higher hypoglycemia risk

Start 2.5 mg once daily

Particularly older adults, hepatic impairment or other predisposition; kidney dysfunction also warrants conservative dosing and monitoring.

Titration and maximum

Adjust to glucose response and tolerance; maximum 20 mg daily

Do not increase through unexplained lows. Take glipizide ER at least four hours before colesevelam.

Before prescribing

Check A1c/glucose, kidney/liver function, meal reliability, hypoglycemia history, concurrent insulin/secretagogues and pregnancy plans. Consider alternatives with less hypoglycemia or desired cardiovascular/kidney benefit. It is not treatment for type 1 diabetes or DKA. Assess G6PD deficiency when relevant.

Side effects and return precautions

Hypoglycemia may be prolonged or recur, particularly with renal/hepatic impairment or inadequate food. Weight gain is common. Severe or recurrent episodes need urgent evaluation; a single corrected value does not guarantee the episode has ended.

Follow-up

Review home readings in 1–2 weeks and after changes; A1c in about three months. Provide a written missed-meal/missed-dose plan and individualize whether rescue glucagon is indicated.

Sources

Checked September 20, 2026.

Glucagon (Baqsimi, Gvoke)Severe low blood sugar

What to say

Glucagon rescues severe low blood sugar, when you’re too confused to eat or drink safely, pass out or have a seizure. Keep it with you, check the expiration date, and show family, friends and coworkers where it is and how to use it. Helpers: don’t put food or drink in the mouth of someone who can’t swallow safely. For Baqsimi, put the tip in one nostril and push the plunger all the way. For Gvoke, inject into the outer thigh, lower belly or outer upper arm.

Then call 911 and turn the person on their side in case they vomit. If there’s no response after 15 minutes, give a second dose from a new device. Once they can swallow, give juice or another fast sugar, then a snack. Nausea and headache are common. It may work poorly after a long time without food. Replace it after use, and call us the same day after any severe low.

Clinical reference

Dose options

Baqsimi nasal powder

3 mg (one device) into one nostril

No priming or test spray; it doesn’t need to be inhaled. If no response in 15 minutes, a second 3 mg dose from a new device may be given while awaiting emergency help.

Gvoke HypoPen, PFS or Kit

1 mg subcutaneously (age ≥12)

Lower abdomen, outer thigh or outer upper arm; repeat from a new device after 15 minutes if no response. Zegalogue (dasiglucagon) 0.6 mg SC is another ready-to-use option.

Who should have it

Everyone taking insulin or at high risk for hypoglycemia (e.g., sulfonylureas or meglitinides with risk factors)

ADA 2026 recommendation 6.16 (grade A); ready-to-use products are preferred over reconstitution kits (grade B). Check formulary coverage.

Before prescribing

Prescribe for insulin users and others at high hypoglycemia risk; train helpers. Contraindicated with pheochromocytoma, insulinoma or prior glucagon hypersensitivity. Prefer ready-to-use products; confirm coverage, storage and expiry.

Side effects and return precautions

Nausea, vomiting (aspiration risk; position on side), headache, transient tachycardia or hypertension. May fail with depleted glycogen (starvation, adrenal insufficiency, chronic hypoglycemia); give glucose instead. Rare hypersensitivity.

Follow-up

Any severe event warrants same-day contact and treatment-plan review, including deintensifying insulin or sulfonylureas. Replace used or expired devices; recheck helper training at visits.

Sources

Checked October 15, 2026.

Human NPH insulin (Humulin N, Novolin N, ReliOn)Lower-cost basal insulin

What to say

For lower-cost control of your morning sugar, start NPH insulin, 10 units under the skin at bedtime. Before each dose, gently roll and tip the vial or pen, as we’ll practice, until it looks evenly milky. With vials, use only U-100 syringes. Check your sugar before breakfast and send readings every 3 days; we’ll usually add 2 units until mornings reach goal. If switching insulins, use only the new dose we write down. Walmart’s ReliOn Novolin N is the same insulin.

NPH works hardest several hours after injection, so lows can happen overnight; keep fast sugar by your bed. If your sugar is below 70 and you can swallow, take 15 grams of fast sugar, such as 4 ounces of juice, and recheck in 15 minutes, repeating if still low. If you can’t swallow, are very confused or have a seizure, someone should give glucagon and call 911, with nothing by mouth. Call us the same day after any low.

Clinical reference

Dose options

Starting bedtime NPH in type 2 diabetes

10 units/day or 0.1–0.2 units/kg/day SC at bedtime; raise about 2 units every 3 days to the fasting goal

ADA 2026 (Fig. 9.5). For a low without a clear cause, lower the dose 10–20%. U-100 only: vials with U-100 syringes, or Humulin N KwikPen or Novolin N FlexPen.

Twice-daily NPH or premixed 70/30

Bedtime NPH to twice daily: total 80% of the bedtime dose, 2/3 in the morning and 1/3 at bedtime

ADA’s example approach; titrate each dose. Premixed NPH/regular 70/30 twice daily before breakfast and dinner is another low-cost option when meal coverage is needed.

Switching from an analog basal insulin

No label conversion; individualize and monitor glucose more often

ADA: basal insulins can often be switched unit for unit, reducing 10–20% when control is tight or hypoglycemia risk is high. In-use discard: Humulin N vial 31 days, KwikPen 14; Novolin N vial 42, FlexPen 28.

  • ADA 2026 lists human insulin among lower-cost options (Walmart: about $25/vial or $43 per 5 pens), but glargine costs only modestly more in its price table, Medicare caps insulin at $35 a month, and CalRx glargine pens are ≤$55 per 5-pack for all Californians. Analogs cause less nocturnal hypoglycemia, so compare actual costs.

Before prescribing

Confirm the product, device and U-100 syringes, ability to mix the suspension, meter or CGM, glucagon, bedtime routine, alcohol, kidney function and sulfonylurea use. Compare actual out-of-pocket costs before choosing NPH over an analog.

Side effects and return precautions

Nocturnal and early-morning hypoglycemia (Humulin N peak effect median 6.5 hours, range 2.8–13), especially with missed meals, alcohol, falling kidney function or sulfonylureas. Weight gain, hypokalemia, lipodystrophy; fluid retention with pioglitazone.

Follow-up

Review fasting readings every 3 days during titration; A1c in about 3 months. For nocturnal lows or missed evening doses, ADA suggests switching to a basal analog. Recheck affordability at refills.

Sources

Checked October 15, 2026.

Hydrochlorothiazide (Microzide)Hypertension

What to say

This is a low-dose water pill called hydrochlorothiazide. Start 12.5 milligrams each morning. It helps the body handle salt and water so blood pressure comes down. Morning dosing makes nighttime bathroom trips less likely.

You may pee more or feel lightheaded, especially if you become dehydrated. Follow your usual fluid plan rather than forcing extra water. We’ll check kidney function, sodium and potassium in the next few weeks and review your home blood pressures. Call the same day for marked weakness, cramps with a racing heartbeat, or an illness that prevents drinking. For sudden eye pain or blurred vision, stop hydrochlorothiazide and get immediate eye care or go to the emergency department. Use sun protection, and let me know if you develop a painful red joint.

Clinical reference

Dose options

Low-dose start

12.5 mg orally each morning

Supported by capsule labeling; a tablet label may specify 25 mg initiation.

Usual next dose

25 mg each morning

Choose from BP response and electrolyte tolerance.

Hypertension ceiling

50 mg/day

Higher doses increase electrolyte adverse effects. Older adults generally start 12.5 mg and use small increments.

Before prescribing

Check BP, sodium/potassium, renal function, gout history, pregnancy and interacting medicines. Contraindicated in anuria; use caution with significant renal impairment.

Side effects and return precautions

Common: increased urination, dizziness, photosensitivity. Important: hyponatremia/hypokalemia, gout, renal dysfunction and rare acute eye reaction. Do not automatically prescribe potassium.

Follow-up

Practical electrolytes/renal and BP check in 2–4 weeks after initiation/change; sooner with frailty, depletion or interactions.

Sources

Checked September 20, 2026.

Hydrocodone/acetaminophen (Norco)Short-term severe acute pain

What to say

For the severe pain from [assessed injury or procedure], we’ve decided on a short rescue prescription because the other treatments haven’t been enough. Take one 5/325-milligram tablet only when needed, at least six hours apart, with no more than four tablets a day under this plan. Use it for [number of days], then check with us if pain still requires it. The two numbers mean hydrocodone 5 milligrams and acetaminophen 325 milligrams.

It can cause sleepiness, nausea and constipation. Don’t drive, drink alcohol or combine it with sleeping or anxiety medicines unless we have specifically reviewed that plan. Don’t add Tylenol or other acetaminophen products without checking the total. Keep it locked away and never share it. If someone is hard to wake or breathing slowly, give naloxone if available and call 911. We’ll explain naloxone use, constipation prevention and how to dispose of leftover tablets.

Clinical reference

Dose options

Short course, opioid-naïve adult

Hydrocodone 5 mg/acetaminophen 325 mg orally: 1 tablet every 6 hours as needed, maximum 4/day in this plan

Set quantity and duration from the expected period of severe pain; this is a conservative prescription, not a standard regimen.

5/325-mg label

1–2 tablets every 4–6 hours as needed; maximum 8 tablets/day

The label ceiling is not a target. Other strengths have different tablet limits.

Acetaminophen / organ function

Count acetaminophen from all products; label ceiling 4,000 mg/day, with lower limits when indicated

Start lower/monitor more closely in renal/hepatic impairment, frailty or respiratory risk. No one-size-fits-all chronic-pain conversion.

Before prescribing

Confirm pain severity, alternative treatments, function goal and expected duration. Review prescription monitoring data, sedation/respiratory risk, pregnancy, substance-use history and CYP3A4 interactions. Offer naloxone and review household risks. Opioid/benzodiazepine combinations need exceptional justification and close planning.

Side effects and return precautions

Sedation, constipation, nausea; dependence, addiction and fatal respiratory depression can occur. Difficulty waking or slow/shallow breathing is an emergency: naloxone and 911. Avoid abrupt discontinuation after established physical dependence; tailor tapering to exposure.

Follow-up

Arrange review before extending an acute course; reassess unexpectedly persistent pain and early adverse effects. Use the smallest quantity needed for the expected severe-pain duration and a specific stop/review date.

Sources

Checked September 20, 2026.

Hydrocortisone 2.5% cream (Hytone)Eczema on the face and skin folds

What to say

For eczema on your face or in skin folds, apply a thin layer of hydrocortisone 2.5% cream to the rash twice a day. It calms redness and itching. Use it for [number of days], and stop sooner once the skin is smooth. Keep it out of your eyes, and don’t cover it with a bandage or wrap. Keep using your moisturizer every day, even after the rash clears.

Mild burning or dryness can happen. Used too often or for too long, it can thin the skin or cause a pimply rash around the mouth, so stop at the planned time. Call us if the rash isn’t clearly better within 2 weeks or returns soon after stopping; we have nonsteroid options for these areas. Call the same day for spreading redness, pus, yellow crusts, fever, or clusters of painful blisters or sores, which can mean infection.

Clinical reference

Dose options

Eczema on the face, neck or skin folds

2.5% cream: thin film twice daily for a short, defined course

The label allows 2–4 times daily but gives no course length; write the site and number of days. Lower-potency steroids on thin skin (face, eyelids, flexures, anogenital) minimize atrophy risk (AAFP).

Strength and product

Rx 2.5% cream or ointment; OTC hydrocortisone is 1% maximum strength

No Hytone-branded label is currently listed on DailyMed; generic 2.5% cream and ointment are available. Advise against layering OTC hydrocortisone on top.

Before prescribing

Confirm steroid-responsive dermatitis; exclude tinea, impetigo, HSV, rosacea and perioral dermatitis. Review site, prior steroid use, occlusion and surface area; extensive or occluded use raises systemic absorption (HPA suppression, hyperglycemia).

Side effects and return precautions

Burning, irritation, folliculitis, acneiform eruptions, perioral dermatitis, hypopigmentation, atrophy and striae. Treat secondary infection or eczema herpeticum promptly; stop the steroid until infection is controlled if response is poor.

Follow-up

Reassess if not improved within 2 weeks or if flares recur quickly; consider a topical calcineurin inhibitor for frequent facial or eyelid flares. Reinforce daily moisturizer (AAD strong recommendation).

Sources

Checked October 15, 2026.

Hydrocortisone rectal cream (Anusol-HC, Proctocort)Hemorrhoids

What to say

Hydrocortisone cream calms itching and irritation around the anus from hemorrhoids. It doesn’t shrink them, so softer stools matter most: take a fiber supplement such as psyllium, drink plenty of fluids, and don’t strain or sit on the toilet for long. Warm sitz baths can ease soreness. Clean and pat the area dry, then apply a thin layer [2 to 4] times a day for up to 7 days.

Longer use can thin the skin, so stop after a week unless we’ve planned otherwise. Call us if it isn’t better within a week or the skin looks raw or infected. Don’t assume bleeding is from hemorrhoids: tell us about new bleeding, especially with a change in bowel habits or weight loss. Call the same day for severe pain, a hard painful lump or fever. Go to the emergency department for heavy bleeding, black stools, dizziness or fainting.

Clinical reference

Dose options

Anusol-HC 2.5% or Proctocort 1% cream

Thin film to the affected perianal skin 2–4 times daily

The Rx labels give no duration; reassess after about 1 week (NIDDK advises follow-up if OTC treatment fails after 1 week). Avoid occlusion and prolonged use.

Core measures

Fiber supplement (e.g., psyllium), fluids, no straining or prolonged toilet sitting, sitz baths several times daily

These treat the hemorrhoids; the steroid is for symptoms only.

  • Rx Anusol-HC 2.5% and Proctocort 1% creams are labeled for corticosteroid-responsive dermatoses; they relieve perianal itching and inflammation but don’t treat the hemorrhoid itself.

Before prescribing

Examine to confirm hemorrhoids and exclude fissure, abscess, thrombosis, dermatitis or infection. Assess bleeding pattern, anemia and colorectal evaluation needs (age, family history, alarm features). Pregnancy needs its own plan.

Side effects and return precautions

Local irritation, skin atrophy, folliculitis, contact dermatitis and secondary infection with prolonged use; rarely systemic absorption. Persistent bleeding, anemia or bowel-habit change needs colorectal evaluation.

Follow-up

Review after 1 week if symptoms persist; consider office procedures (e.g., rubber band ligation) or referral for refractory or prolapsing hemorrhoids. Confirm any due colonoscopy is arranged.

Sources

Checked October 15, 2026.

Hydroxychloroquine (Plaquenil)Rheumatoid arthritis and lupus

What to say

Hydroxychloroquine calms the immune system in lupus and rheumatoid arthritis. Take [dose] milligrams daily with food or milk; we set the dose by your weight to protect your eyes. Swallow the tablets whole. It works slowly: you may feel better in 1–2 months, and the full benefit can take up to 6 months, so keep taking it even if you don’t notice a change at first.

Upset stomach, diarrhea and rash can happen. Over years, it can damage the retina, so you’ll have an eye exam soon after starting and regular screening later. Tell us about any change in your vision. It can lower blood sugar, so check more often if you have diabetes. Call us for a rash, muscle weakness or mood changes. Fainting or a pounding, irregular heartbeat needs emergency care. If you have thoughts of harming yourself, call 911 or 988.

Clinical reference

Dose options

RA or lupus

200–400 mg daily as one dose or two divided doses, not more than 5 mg/kg actual body weight per day

AAO 2025: ≤5.0 mg/kg/day real weight and under 400 mg/day in severe obesity. The label’s RA initial dose of 400–600 mg/day can exceed this; follow the weight limit.

Administration and risk factors

Take with food or milk; don’t crush or divide current Plaquenil tablets

Renal disease, tamoxifen and older age at initiation raise retinopathy risk (AAO); screen accordingly.

Before prescribing

Weigh the patient; cap at ≤5 mg/kg/day. Check QT risk (cardiac disease, QT-prolonging drugs, electrolytes), renal/hepatic function, tamoxifen, macular disease, G6PD deficiency, porphyria, psoriasis and diabetes drugs.

Side effects and return precautions

GI upset, rash; QT prolongation, arrhythmia, cardiomyopathy; severe hypoglycemia; SJS/TEN/DRESS; myopathy/neuropathy; suicidality; cytopenias or hemolysis with G6PD deficiency; irreversible retinopathy.

Follow-up

Baseline retinal exam with OCT and fundus autofluorescence soon after starting; annual screening, deferrable for the first 5 years without risk factors (AAO 2025). Reassess benefit at 3–6 months.

Sources

Checked October 15, 2026.

Hydroxyzine hydrochloride (Atarax)Itching

What to say

For the itching, try hydroxyzine 25 milligrams at bedtime as needed for the brief course we agreed on. This is a deliberately low schedule because it can make you sleepy. It helps itching but doesn’t treat every cause of a rash. Don’t add daytime doses without checking, and avoid driving until you know its effects.

Dry mouth, constipation or grogginess can happen. Don’t combine it with alcohol, sleep medicines, opioids or other sedating antihistamines without review. Stop and get urgent help for a new racing or irregular heartbeat. Fainting or chest pain means call 911. Tell us if itching persists, spreads or comes with new symptoms so we can revisit the cause.

Clinical reference

Dose options

Conservative short course

25 mg orally at bedtime as needed

U.S. pruritus label: 25 mg three or four times daily; individualize down for sedation and risk.

Cardiac and age considerations

Use the lowest effective dose for the shortest duration

EMA caps adults at 100 mg/day and older adults at 50 mg/day if unavoidable; these are European restrictions. Generally avoid in older adults; prolonged QT is contraindicated.

Before prescribing

Check QT/arrhythmia history, electrolyte problems, glaucoma/urinary retention, sedation/fall risk and other QT-prolonging drugs. Prolonged QT and early pregnancy are contraindications; review breastfeeding and allergy to hydroxyzine/cetirizine-related products.

Side effects and return precautions

Sedation, dry mouth, constipation and confusion may occur. Palpitations require stopping and prompt assessment; syncope needs emergency evaluation. Avoid stacking sedatives. Serious blistering/pustular rash needs urgent assessment.

Follow-up

Review itch relief, cause, sedation and continuing need within 1–2 weeks or sooner if rash worsens. Avoid continuing a sedating antihistamine indefinitely without reassessing the diagnosis.

Sources

Checked September 22, 2026.

Hydroxyzine hydrochloride (Atarax)Short-term anxiety

What to say

For brief episodes of anxiety while we work on your longer-term treatment, try hydroxyzine 25 milligrams when needed, at least twelve hours apart and no more than twice in a day for this plan. Try the first dose at home when you won’t need to drive. It can work the same day, but it often causes sleepiness and dry mouth.

Don’t combine it with alcohol, sleep medicines, opioids, or other sedating antihistamines unless we have reviewed the combination. Don’t drive until you know its effects, and never drive while sleepy. Stop it and go to the emergency department for a new racing or irregular heartbeat. Fainting or a fast heartbeat with chest pain means call 911. We’ll review in one to two weeks. If you need it most days, tell me so we can revisit the underlying anxiety treatment rather than keep increasing it. There’s no missed dose to make up when used only as needed.

Clinical reference

Dose options

Short-term anxiety

25 mg orally as needed, at least 12 hours apart, up to twice daily

A conservative dose below the older U.S. label anxiety schedule. Use the lowest effective dose briefly; it is not a long-term anxiety strategy.

Label and safety-limit distinction

U.S. label anxiety dosing is 50–100 mg four times daily; do not default to this high schedule

EMA cardiac-risk restrictions instead cap adults at 100 mg/day and older adults at 50 mg/day if unavoidable. These are European limits, not a claimed U.S. FDA maximum.

Older adults and organ impairment

Generally avoid in older adults

Sedation, falls and anticholinergic effects; individualize cautiously in kidney/liver impairment.

Before prescribing

Check QT/arrhythmia history, electrolyte problems, glaucoma/urinary retention, sedation/fall risk and other QT-prolonging drugs. Prolonged QT and early pregnancy are contraindications; review breastfeeding and allergy to hydroxyzine/cetirizine-related products.

Side effects and return precautions

Sedation, dry mouth, constipation and confusion may occur. Palpitations require stopping and prompt assessment; syncope needs emergency evaluation. Avoid stacking sedatives. Serious blistering/pustular rash needs urgent assessment.

Follow-up

Review need, function and sedation in 1–2 weeks. Long-term anxiety benefit beyond 4 months has not been systematically established; record a stop/review date and address persistent symptoms.

Sources

Checked September 22, 2026.

Ibuprofen (Advil, Motrin)Acute pain

What to say

For this short course, take ibuprofen 400 milligrams every six hours only if needed for pain, through [stop or review date]. That’s two of the 200-milligram tablets per dose, with no more than four doses in a day under this prescription plan. Take it with water and food if it upsets your stomach.

Don’t combine it with naproxen or other anti-inflammatory pain medicines. Check with us if you take aspirin or a blood thinner. Stop it and go to the emergency department for black, sticky stools or vomiting blood. Call 911 for chest pain, trouble breathing or a drooping face, arm weakness or trouble speaking. Stop and call the same day for much less urine or significant swelling. Tell us if you’re pregnant or could be. Contact us if pain worsens or isn’t improving by our review date.

Clinical reference

Dose options

Short prescription course

400 mg every 6 hours as needed; maximum 1,600 mg/day for this course

OTC self-treatment maximum is generally 1,200 mg/day. Give an actual duration.

Label acute pain option

400 mg every 4–6 hours as needed

Doses above 400 mg did not improve analgesia in controlled trials.

Inflammatory arthritis

Prescription total 1,200–3,200 mg/day in divided doses

Higher doses require individualized benefit/risk assessment; 3,200 mg is a ceiling, not a target.

Before prescribing

Review kidney function, volume status, ulcer/bleeding history, BP/heart failure, anticoagulants and aspirin. Avoid NSAIDs from 20 weeks of pregnancy unless specifically indicated; avoid at about 30 weeks and later.

Side effects and return precautions

Dyspepsia, GI bleeding, kidney injury, fluid retention and cardiovascular events. Food does not prevent serious GI bleeding.

Follow-up

Reassess at the specified short-course endpoint. Check BP/renal function if ongoing use or risk factors warrant it.

Sources

Checked September 20, 2026.

Icosapent ethyl (Vascepa)Cardiovascular risk reduction with high triglycerides

What to say

Icosapent ethyl is a purified prescription omega-3 made from fish oil. Added to your statin, it can lower the chance of a heart attack or stroke in people with high triglycerides who have heart disease, or diabetes plus other risks. Take 2 grams twice a day with meals, swallowing the capsules whole. Over-the-counter fish oil isn’t the same and hasn’t shown this benefit.

Muscle or joint aches, ankle swelling, constipation and gout flares can happen. It slightly raises the risk of atrial fibrillation, an irregular heartbeat: call us for a new racing or irregular pulse, and call 911 if it comes with chest pain or fainting. Bleeding is more likely, especially with aspirin or blood thinners; black or bloody stools, or bleeding that won’t stop, need emergency care. Tell us about fish or shellfish allergy; for face swelling or trouble breathing, call 911.

Clinical reference

Dose options

Cardiovascular risk reduction, added to maximally tolerated statin

2 g (two 1 g or four 0.5 g capsules) orally twice daily with food; 4 g/day

Label: TG ≥150 mg/dL with established CVD, or diabetes plus ≥2 more risk factors. 2026 ACC/AHA (COR 2b): may be reasonable at age ≥50 with ASCVD, or diabetes plus ≥1 risk factor, persistent TG 150–499 mg/dL and LDL-C <100 mg/dL on maximally tolerated statin.

Products

Generic icosapent ethyl is the same drug at the same 4 g/day dose

Generic labels list only the severe hypertriglyceridemia (≥500 mg/dL) indication. Not interchangeable with OTC fish oil or EPA+DHA products; 2026 ACC/AHA recommends against supplements for lipid or ASCVD lowering.

  • 2026 ACC/AHA notes REDUCE-IT’s mineral-oil placebo may have exaggerated benefit; weigh the modest absolute benefit against AF and bleeding risk.

Before prescribing

Confirm statin at maximally tolerated dose and LDL-C addressed first. Check fasting TG and secondary causes (glycemia, hypothyroidism, alcohol, drugs). Ask about AF, antiplatelets/anticoagulants, bleeding history and fish or shellfish allergy.

Side effects and return precautions

AF/flutter (more with prior AF), bleeding (more with antithrombotics), peripheral edema, musculoskeletal pain, constipation, gout. Stop for hypersensitivity.

Follow-up

Lipid panel 4–12 weeks after starting, then with statin changes or every 6–12 months. Review palpitations and bleeding at visits. Benefit isn’t judged by the TG change alone.

Sources

Checked October 15, 2026.

Imiquimod 5% cream (Aldara)Genital warts

What to say

Imiquimod cream helps your immune system clear warts on the genitals or around the anus. Three nights a week, such as Monday, Wednesday and Friday, wash the area and let it dry for 10 minutes. Then rub a thin layer into the warts at bedtime until the cream disappears. Wash it off with soap and water 6–10 hours later. Continue until the warts are gone, for up to 16 weeks. Don’t cover it or use it inside the vagina or anus.

Redness, itching, burning and peeling are common. If the skin breaks open or gets very sore, take a few days off and call us. Flu-like aches can happen. Avoid sex while the cream is on, because it can weaken condoms and diaphragms. Severe swelling or trouble passing urine means stop it and call the same day; if you can’t pass urine at all, go to the emergency department. Warts can come back, because treatment doesn’t clear the virus. Tell us if you’re pregnant; we’d use another treatment.

Clinical reference

Dose options

External genital and perianal warts, ages 12 and older

Thin layer at bedtime 3 times weekly; wash off after 6–10 hours; until clearance or a maximum of 16 weeks

One 250 mg packet covers up to 20 cm²; discard partly used packets. Rest days are allowed for local reactions. A missed dose is simply skipped; apply the next one on schedule.

Other strengths and indications

Imiquimod 3.75% (Zyclara): nightly for up to 8 weeks for warts. Imiquimod 5% for actinic keratoses: 2 times weekly for 16 weeks; superficial BCC: 5 times weekly for 6 weeks

Schedules are not interchangeable between strengths or indications.

  • The Aldara brand is discontinued in the US; generic imiquimod 5% cream packets are the available product.

Before prescribing

Confirm typical external anogenital warts; biopsy atypical, pigmented, indurated, ulcerated or nonresponding lesions. Not for vaginal, cervical, urethral or anal canal warts. Avoid in pregnancy; caution with psoriasis, vitiligo or other inflammatory skin disease. Offer STI testing and HPV vaccination if eligible.

Side effects and return precautions

Local erythema, erosion and weeping; flu-like symptoms; severe vulvar swelling with urinary retention; lasting hypopigmentation or depigmentation; flares of psoriasis or vitiligo; sunburn susceptibility.

Follow-up

Warts typically respond within 3 months; change approach if there’s no improvement or reactions are severe. Recurrence is common, especially in the first 3 months. Advise telling current partners; partner HPV testing isn’t recommended.

Sources

Checked October 15, 2026.

Inclisiran (Leqvio)LDL cholesterol lowering

What to say

Inclisiran is a long-acting injection that helps your liver clear LDL, the “bad” cholesterol, lowering it by about half. A nurse or clinician gives 284 milligrams under the skin: a first dose, another at 3 months, then 1 every 6 months. If a dose is more than 3 months late, we restart that schedule. Keep taking your statin unless we say otherwise. Studies are still underway to show whether it lowers heart attack and stroke risk.

Side effects are usually mild: soreness, redness or rash where the shot was given, joint pain, or a chest cold. Serious allergic reactions are rare; call 911 for swelling of your face, lips or tongue, or trouble breathing. Tell us if you could be pregnant or are planning pregnancy, since it’s usually stopped during pregnancy. We’ll recheck your cholesterol in 1–3 months.

Clinical reference

Dose options

Adults with hypercholesterolemia, including HeFH

284 mg SC by a health care professional at day 0, month 3, then every 6 months

Missed by <3 months: give and keep the original schedule. Missed by >3 months: restart (dose, 3 months, then every 6 months). LDL-C can be checked from 30 days, regardless of dose timing.

Place in therapy (2026 ACC/AHA, COR 2a)

Very high-risk ASCVD on maximally tolerated statin ± ezetimibe when a PCSK9 antibody isn’t tolerated or obtainable, or less frequent dosing is preferred

Labeled for LDL-C lowering only. Outcome trials (ORION-4, VICTORION-2P) were still active without results as of October 2026.

Before prescribing

Confirm LDL-C above goal despite maximally tolerated statin ± ezetimibe. Prior serious hypersensitivity (anaphylaxis, angioedema) contraindicates. Discuss pregnancy plans. Arrange clinic administration and benefit verification (medical vs pharmacy benefit).

Side effects and return precautions

Injection-site reactions (8%), arthralgia, bronchitis. Hypersensitivity including anaphylaxis and angioedema. Don’t inject into areas of active skin disease, sunburn or infection.

Follow-up

Lipid panel 4–12 weeks after starting, then every 6–12 months. Track the dosing calendar; restart the loading schedule if a dose is more than 3 months late.

Sources

Checked October 15, 2026.

Insulin glargine U-100 (Lantus SoloStar)Type 2 diabetes, starting basal insulin

What to say

For your type 2 diabetes, we’re adding Lantus U-100 at 10 units under the skin every evening at the same time. We’ll demonstrate the pen and have you show us a dose before you leave. Rotate injection sites and never share the pen. Check glucose each morning before breakfast and whenever you feel shaky, sweaty or unwell. Send the first three mornings’ readings to us so we can adjust the dose together.

If glucose is below 70 mg/dL and you can swallow safely, take 15 grams of fast sugar, such as glucose tablets or gel totaling 15 grams according to the package and recheck in 15 minutes, repeating if still low. For severe confusion, seizure or inability to swallow, a helper should give the prescribed glucagon and call 911. No food or drink by mouth. Call us the same day after any low reading. We’ll give you written sick-day and missed-dose instructions. Don’t double a forgotten dose or change insulin strengths yourself.

Clinical reference

Dose options

Insulin-naive type 2 diabetes

Lantus U-100: 0.2 units/kg or up to 10 units subcutaneously once daily

The wording above uses 10 units. Individualize lower starting doses for substantial hypoglycemia risk. U-300 and other basal products have different conversion/titration rules.

Titration

Review at least three fasting readings with the team every 3–7 days; a common adjustment is 2 units

Write the individualized fasting target, increase/decrease rules and contact thresholds. No increase after any unexplained low; recurrent lows require dose reduction and review. There is no universal maximum.

Administration

Same time daily; rotate sites, check label and pen dose, use a new needle and prime as taught

Do not mix/dilute Lantus or withdraw insulin from a pen into a syringe. Type 1 diabetes needs a complete basal/meal plan, not this type 2 starting schedule.

Before prescribing

Check A1c, glucose pattern, kidney/liver function, hypoglycemia risk and ability to use supplies. Provide meter/CGM access, glucagon, pen teach-back, storage instructions and caregiver training. Review whether to reduce/stop sulfonylureas. Specify glucose targets, low/high thresholds, illness/ketone guidance and an actual titration contact.

Side effects and return precautions

Hypoglycemia is the main acute risk; weight gain and injection-site changes occur. Renal decline, missed food, alcohol or increased activity may lower requirements. Severe hyperglycemia with vomiting, deep breathing, confusion or dehydration requires urgent/emergency assessment.

Follow-up

Review initial readings in three days, then every 3–7 days during adjustment; reassess A1c at about three months. Confirm the patient can access insulin, glucose testing and rescue treatment before starting.

Sources

Checked September 20, 2026.

Insulin lispro U-100 (Humalog KwikPen)Type 2 diabetes, adding mealtime insulin

What to say

Your morning glucose is near target, but your largest meal still raises it too much. Alongside your existing basal insulin, start Humalog U-100 at 4 units with that meal. Inject within 15 minutes before eating, or immediately afterward if intake was uncertain. If you skip the meal, skip this meal dose. Don’t add correction doses without our written plan. Check glucose before meals and at bedtime or use your glucose sensor, and send us readings in three days.

We’ll practice the pen and label checks together. Never share pens. If glucose is below 70 mg/dL and you can swallow, take 15 grams of fast sugar, such as glucose tablets or gel totaling 15 grams according to the package, recheck in 15 minutes and repeat if needed. If you can’t safely swallow, have a seizure or need help because of severe confusion, a helper should give glucagon and call 911 without putting food or drink in your mouth. Call us the same day after a low so we can adjust your plan.

Clinical reference

Dose options

Add a meal dose in type 2 diabetes

4 units, or 10% of the basal dose, at the largest meal or greatest post-meal excursion

The wording above uses 4 units while continuing basal insulin; reassess basal dose if A1c is near goal or hypoglycemia is a concern.

Meal timing

Humalog U-100 subcutaneously within 15 minutes before or immediately after a meal

Dose depends on carbohydrate intake and glucose pattern. Skipping a meal means omitting its nutritional dose; a separately prescribed correction plan may still apply.

Dose adjustment

Review meal/bedtime or CGM patterns with the team every few days initially

Individualize increments and reductions. There is no universal maximum or standard sliding scale. Type 1 diabetes requires its own carbohydrate-ratio/correction plan.

Formulation safety

Confirm Humalog U-100 and the prescribed device each time

U-100 and U-200 pens display units without conversion, but do not switch products casually or remove insulin from a pen with a syringe. Do not mix with glargine.

Before prescribing

Confirm basal regimen, meal pattern, A1c, renal/hepatic status and hypoglycemia awareness. Provide CGM/meter, glucagon, carbohydrate education, injection/priming/storage teach-back, written targets and sick-day rules. Review sulfonylurea need. Make dose decisions from the meal-related pattern, not fasting glucose alone.

Side effects and return precautions

Fast-acting insulin can cause severe hypoglycemia when eating is delayed, intake falls or doses are repeated too close together. Treat lows immediately and revise the regimen; never improvise extra correction doses. Rotate sites and inspect for lipohypertrophy.

Follow-up

Review readings and actual meal intake in three days and every few days during initial adjustment; assess A1c around three months. Confirm practical access to supplies and who will respond to the glucose log.

Sources

Checked September 20, 2026.

Isoniazid and rifapentine (3HP; Priftin)Latent TB infection

What to say

This treatment kills sleeping TB germs before they can make you sick. Once a week, on the same day, take your isoniazid and rifapentine pills together with food, for 12 weeks. Your dose depends on your weight; most adults take 900 milligrams of each. We may add vitamin B6 to protect your nerves. Write down each dose, and call us if you miss one. We’ll check in every month.

Your urine, tears and sweat may turn orange; it’s harmless but can stain soft contacts. Stop the pills and call us the same day for flu-like illness, rash, nausea, vomiting, dark urine, yellow eyes, belly pain or tingling hands. Dizziness or fainting after a dose means go to the emergency department. Trouble breathing or facial swelling means call 911. Rifapentine can make hormonal birth control less effective, so use condoms or a nonhormonal method, and tell us if you could become pregnant. Check with us before starting any new medicine, especially HIV medicines or blood thinners.

Clinical reference

Dose options

3HP, adults (self-administered or directly observed)

Once weekly for 12 doses: isoniazid 15 mg/kg rounded up to the nearest 50 or 100 mg (max 900 mg) plus rifapentine 750 mg (32.1–49.9 kg) or 900 mg (≥50 kg)

CDC allows self-administered therapy with a dose log or DOT; consider DOT for those at highest risk of progression. The Priftin label specifies DOT and isoniazid rounded to the nearest 50 or 100 mg. Give rifapentine with food.

Pyridoxine for neuropathy risk

Vitamin B6 50 mg once weekly with each dose

CDC: for diabetes, HIV, alcohol use disorder, malnutrition, chronic kidney failure, advanced age, pregnancy or breastfeeding.

Before prescribing

Exclude active TB (symptoms, chest x-ray). Not for pregnancy or planned pregnancy during treatment, rifamycin allergy, or contacts of isoniazid- or rifampin-resistant TB. Full interaction review (hormonal contraception, anticoagulants, methadone, ART). Baseline LFTs with liver disease, HIV, regular alcohol use, injection drug use or ≤3 months postpartum.

Side effects and return precautions

Flu-like or systemic reactions in about 4%, usually after doses 3–4 and about 4 hours post-dose; rare hypotension or syncope. Hold for AST ≥3× ULN with symptoms or ≥5× ULN without. Rash, SJS or DRESS, neuropathy, thrombocytopenia.

Follow-up

Monthly in-person or phone review of adherence (dose log), TB symptoms and adverse effects. Repeat LFTs if baseline abnormal, at risk or symptomatic. Document completion; evaluate new TB symptoms promptly.

Sources

Checked October 15, 2026.

Isosorbide mononitrate ER (Imdur)Chronic angina

What to say

Isosorbide mononitrate relaxes blood vessels so your heart needs less oxygen, which helps prevent angina, chest pain or pressure with exertion. Take one extended-release tablet, usually 30 or 60 milligrams, once each morning when you get up; don’t crush or chew it. The overnight break keeps it working, so don’t add doses. It won’t stop an attack that has already started, so keep your nitroglycerin with you.

Headaches are common early and usually ease; acetaminophen can help, but don’t skip doses to avoid them. Stand up slowly, and limit alcohol, which adds to dizziness. Never combine it with erection medicines such as sildenafil, tadalafil or vardenafil, or with riociguat; blood pressure can drop dangerously. If chest pain isn’t better 5 minutes after one nitroglycerin, or you faint, call 911. Call us the same day if angina comes more often or with less effort.

Clinical reference

Dose options

Chronic stable angina prevention (ER tablets)

30 or 60 mg once daily on arising; may increase after several days to 120 mg once daily (rarely 240 mg)

Swallow with half a glass of fluid; don’t chew or crush (30 mg may be half of a scored 60 mg tablet). Once-daily morning dosing leaves a low-nitrate interval that limits tolerance.

Acute angina

Also prescribe sublingual nitroglycerin 0.4 mg tablets or spray

ISMN onset is too slow to abort an attack. ER and immediate-release ISMN have different schedules; don’t substitute without adjusting timing.

Before prescribing

Contraindicated with PDE5 inhibitors (sildenafil, tadalafil, vardenafil, avanafil) and riociguat; nitrate hypersensitivity. Caution with hypotension, volume depletion, hypertrophic cardiomyopathy, recent MI or HF. Beta-blocker or CCB is first-line antianginal therapy.

Side effects and return precautions

Headache, dizziness, orthostatic hypotension (additive with alcohol, CCBs and other vasodilators), flushing, paradoxical bradycardia; tolerance with frequent dosing; rarely methemoglobinemia.

Follow-up

Review angina frequency, exercise tolerance and nitroglycerin use in 2–4 weeks. New, more frequent or rest angina needs urgent evaluation. Avoid abrupt withdrawal of long-term nitrate therapy.

Sources

Checked October 15, 2026.

Ivermectin 1% cream (Soolantra)Rosacea

What to say

For the red bumps and pimples of rosacea, apply ivermectin 1% cream once a day. Use a pea-size amount for each affected area of your face, such as your forehead, chin, nose and each cheek, and spread it in a thin layer. Keep it away from your eyes and lips. Improvement is gradual. It may start within about 4 weeks, and we’ll judge the full effect at 12 weeks.

Side effects are uncommon, but mild burning or irritation can happen. Stop it and call us if your skin becomes very irritated or swollen. Gentle skin care, daily sunscreen and avoiding your triggers, such as alcohol, spicy food, hot drinks or heat, can help. Rosacea is long-term, so if the cream helps, we’ll talk about continuing it. Get same-day care for eye pain, light sensitivity or blurred vision.

Clinical reference

Dose options

Inflammatory papules and pustules of rosacea

1% cream once daily: pea-size amount per affected area (forehead, chin, nose, each cheek)

Pivotal trials used bedtime application for 12 weeks: clear or almost clear in 38–40% vs 12–19% with vehicle. Long-term use studied for about 1 year. Generic 1% cream available.

Comparative evidence

Once-daily ivermectin 1% outperformed metronidazole 0.75% cream twice daily at 16 weeks

ATTRACT trial (n=962): inflammatory lesion reduction 83.0% vs 73.7%, with better local tolerability. The indication covers inflammatory lesions, not background redness or flushing.

Before prescribing

Confirm papulopustular rosacea rather than acne, perioral (steroid-related) dermatitis or seborrheic dermatitis; ask about facial steroid use. No contraindications; pregnancy data are insufficient. Ask about eye symptoms.

Side effects and return precautions

Skin burning and irritation (1% or less in trials). Worsening or a new pattern suggests another diagnosis. Eye pain, photophobia or vision change needs same-day ophthalmic assessment.

Follow-up

Review at 12 weeks and continue if helpful, since rosacea is chronic. If response is inadequate, add or switch to azelaic acid, metronidazole or oral doxycycline by severity.

Sources

Checked October 15, 2026.

Ivermectin tablets (Stromectol)Scabies, off-label

What to say

We’re using ivermectin tablets off-label for scabies. They’re approved for worm infections, and CDC lists them for scabies. Take [number] tablets, [dose] milligrams based on your weight, all at once with a meal. Repeat the dose on [date], 7–14 days later. Household members and close contacts should be treated at the same time. Wash bedding, towels and clothes used in the last 3 days in hot water and dry them hot; seal what you can’t wash in a bag for at least 3 days.

Itching can last several weeks after the mites are gone. Call us if it lasts more than 2–4 weeks or new bumps or burrows appear. Side effects are usually mild, such as dizziness or nausea. Tell us if you take warfarin, are pregnant or breastfeeding, or have lived in Central or West Africa. Call the same day for spreading redness, pus or fever.

Clinical reference

Dose options

Classic scabies (off-label; CDC)

200 mcg/kg orally with food; repeat 7–14 days later

The label (strongyloidiasis, onchocerciasis) says take on an empty stomach; CDC notes scabies experts advise a meal, and a high-fat meal raised bioavailability about 2.5-fold. 3-mg tablets; label bands: 51–65 kg 4 tablets, 66–79 kg 5, ≥80 kg 200 mcg/kg.

Crusted scabies

200 mcg/kg on days 1, 2 and 8; 5 or 7 doses by severity (add days 9 and 15, then 22 and 29), with whole-body permethrin 5%

CDC options; no agreed frequency. Co-manage with dermatology or ID, and involve public health for institutional outbreaks.

  • Not FDA approved for scabies (labeled for strongyloidiasis and onchocerciasis); CDC lists oral ivermectin with topical permethrin as first-line options of similar efficacy.

Before prescribing

Confirm diagnosis and identify all close contacts. Pregnancy: safety not established, so use permethrin. Breastfeeding: weigh risk. Warfarin (INR rises reported). Loa loa exposure (West or Central Africa): assess before treatment. Consider crusted scabies if immunosuppressed.

Side effects and return precautions

Usually mild: dizziness, nausea, diarrhea, pruritus. Post-scabetic itch is common; distinguish from reinfestation, missed contacts or secondary bacterial infection. Rare severe encephalopathy with heavy Loa loa infection.

Follow-up

Confirm the second dose and simultaneous contact treatment. Reassess itch beyond 2–4 weeks, new burrows or new rash (CDC retreatment criteria). Institutional clusters need public health coordination.

Sources

Checked October 15, 2026.

Ketoconazole 2% creamFacial seborrheic dermatitis

What to say

For seborrheic dermatitis on your face or body, apply a thin layer of ketoconazole 2% cream to the red, flaky areas twice a day for 4 weeks, or until clear. It calms the skin yeast that drives this rash. Keep it out of your eyes. If your scalp is involved, use a dandruff shampoo too. This rash often returns, so we’ll plan what to do for future flares.

Mild burning, stinging or irritation can happen. Stop it and call us if you get a worsening red, itchy rash, blisters or swelling. The cream contains a sulfite, so tell us if sulfites have ever caused you a reaction or asthma attack. Trouble breathing or swelling of your lips or tongue means call 911. If it hasn’t improved after 4 weeks, we’ll reconsider the diagnosis. Call sooner for spreading redness, pain, crusting or pus.

Clinical reference

Dose options

Seborrheic dermatitis (labeled)

2% cream to affected areas twice daily for 4 weeks or until clinical clearing

Reassess the diagnosis if not improved. Tinea and candida indications use once daily.

Recurrence

Retreat flares; individualize maintenance

No maintenance schedule in the label. Add medicated shampoo for the scalp; a corticosteroid may be added if antifungals alone don’t control it (AAD).

Before prescribing

Confirm seborrheic dermatitis rather than rosacea, psoriasis, contact dermatitis, tinea or lupus. Ask about sulfite sensitivity; the cream contains sodium sulfite and propylene glycol.

Side effects and return precautions

Irritation, pruritus, stinging; rare contact dermatitis. Sulfite reactions can include anaphylaxis or asthma. Pain, crusting or pus suggests infection.

Follow-up

Review at 4 weeks; if not improved, reassess the diagnosis. Agree on a flare plan, including scalp shampoo and intermittent retreatment.

Sources

Checked October 15, 2026.

Ketoconazole 2% shampoo (Nizoral)Scalp seborrheic dermatitis, off-label

What to say

For the flaky, itchy scalp from seborrheic dermatitis, use ketoconazole 2% shampoo twice a week for four weeks. Wet your hair and scalp, massage it into the affected scalp, leave it for three to five minutes, then rinse thoroughly. Keep it out of your eyes. If it gets in, rinse with water.

It helps control the yeast that contributes to this condition. Mild burning, irritation or a change in hair texture can occur. Stop and contact us if irritation is significant or a new rash develops. Swelling of the lips or tongue or trouble breathing means call 911. We’ll review the scalp after four weeks. If it works but flaking returns, we can agree on occasional maintenance use rather than repeatedly starting full courses. Tell us sooner about a painful scalp, pus or patchy hair loss.

Clinical reference

Dose options

Scalp seborrheic dermatitis

2% shampoo twice weekly for 2–4 weeks; leave 3–5 minutes then rinse

NHS-supported regimen; this scalp indication is off-label for the cited U.S. 2% product.

Maintenance after response

Once every 1–2 weeks if needed

Individualize recurrence prevention; reassess persistent symptoms.

Before prescribing

Confirm seborrheic dermatitis rather than tinea capitis, psoriasis or contact dermatitis. Identify exact strength and avoid applying oral-ketoconazole risk statements to shampoo.

Side effects and return precautions

Local burning/irritation and hair-texture change; stop for sensitization. Marked inflammation, infection signs or focal hair loss warrants reassessment.

Follow-up

Review at four weeks; select maintenance only after response. Persistent disease needs diagnostic review rather than indefinite escalation.

Sources

Checked September 22, 2026.

Ketoconazole 2% shampoo (Nizoral)Tinea versicolor

What to say

For tinea versicolor, the yeast-related patches on your skin, apply ketoconazole 2% shampoo once to the damp affected skin and a little beyond it. Lather, leave it for five minutes, then rinse well. This is a skin treatment with a one-application schedule, not the repeated scalp schedule. Skin color may take weeks to months to even out after the yeast is controlled.

Keep it out of your eyes and rinse with water if contact occurs. Mild irritation can happen. Stop and contact us for significant burning or a new rash. Trouble breathing or tongue swelling means call 911. If scaling persists or the diagnosis seems uncertain, come back rather than repeating treatment just because the color hasn’t returned.

Clinical reference

Dose options

U.S. 2% label: tinea versicolor

One application to affected damp skin; lather, leave 5 minutes, rinse

Use the prescription 2% product. The OTC 1% shampoo has different directions.

Before prescribing

Confirm tinea versicolor rather than vitiligo or another pigment disorder; identify 2% shampoo and local extent. Review allergy and avoid eye/mucosal contact.

Side effects and return precautions

Local irritation or sensitization. Persistent pigmentation alone does not prove ongoing infection; recurrent scale or new lesions warrants reassessment.

Follow-up

Review persistent scale or new lesions after treatment. Explain that pigment recovery lags; recurrent disease may need a separate prevention plan.

Sources

Checked September 22, 2026.

Lamotrigine (Lamictal)Bipolar disorder maintenance

What to say

To help prevent future mood episodes, especially depression, we’re starting lamotrigine; it doesn’t treat a current episode. The dose rises slowly to lower the risk of a serious rash: 25 milligrams daily for two weeks, 50 milligrams daily for two weeks, 100 milligrams daily for one week, then 200 milligrams daily. Follow the written schedule exactly. If you miss five or more days, call us before restarting; you may need to start over.

Headache, dizziness, nausea or trouble sleeping can happen. Call the same day about any new rash, before taking another dose. A rash with fever, blisters, peeling, or mouth or eye sores means stop it and go to the emergency department. Fever with swollen glands, or a severe headache and stiff neck, needs same-day care. Call the same day for worsening mood or thoughts of self-harm; if you might act on them, call 911. Tell us before starting or stopping estrogen birth control, and don’t stop lamotrigine suddenly.

Clinical reference

Dose options

Adults, no valproate or enzyme inducers

25 mg daily weeks 1–2; 50 mg daily weeks 3–4; 100 mg daily week 5; 200 mg daily from week 6

Target 200 mg/day; higher doses are not recommended (no added benefit). Starter kits follow this schedule. Taper over ≥2 weeks (about 50% per week) unless rash requires stopping.

With valproate or enzyme inducers

Valproate: 25 mg every other day weeks 1–2, 25 mg daily weeks 3–4, 50 mg week 5, 100 mg target from week 6. Carbamazepine, phenytoin, phenobarbital, primidone or rifampin (no valproate): 50, 100, 200, 300, then up to 400 mg/day (divided) at weeks 1–2, 3–4, 5, 6 and 7

Adjust when these drugs are started or stopped (label Table 6). Never exceed the starting dose or escalation rate.

Estrogen, restarting, liver disease

Estrogen-containing contraception: same titration; maintenance may need up to 2×; reduce by up to 50% if it is stopped

Pill-free weeks can raise levels. Restart titration if off >5 half-lives (about 5 days on monotherapy). Moderate–severe hepatic impairment: reduce about 25% (50% with ascites). Progestin-only methods need no change.

  • Prevents depressive relapse more than mania (CANMAT/ISBD 2018: first-line maintenance, limited antimanic prophylaxis). Lamictal XR is not approved for bipolar disorder.

Before prescribing

Confirm bipolar I maintenance, not acute mania. Review valproate, enzyme inducers, estrogen contraception or HRT, prior antiseizure-drug rash, known HLA-B*1502, structural or conduction heart disease (class IB effect), suicide risk and pregnancy plans.

Side effects and return precautions

Boxed warning: serious rash/SJS/TEN, mostly at 2–8 weeks; stop at first rash unless clearly unrelated. DRESS, HLH, aseptic meningitis, blood dyscrasias, arrhythmia in heart disease, suicidality, name mix-ups, false-positive PCP screens.

Follow-up

Check in every 1–2 weeks during titration about rash, adherence and mood. Reassess need periodically after 16 weeks; watch for emerging mania and coordinate with psychiatry. Taper over ≥2 weeks to stop.

Sources

Checked October 15, 2026.

Lenacapavir (Yeztugo)HIV prevention (PrEP)

What to say

Yeztugo helps prevent HIV from sex with injections every six months. On the first day, you receive two injections under the skin and take two 300-milligram tablets. The next day, take two more tablets. After that, each visit involves two injections, usually 26 weeks apart.

Small lumps, soreness or firmness can develop where the injections were given. Lumps can last months or longer. We’ll test for HIV before starting and before repeat injections. Call promptly for flu-like symptoms after an exposure. Contact us early if an appointment may be delayed or you want to stop, so we can keep protection in place. This doesn’t prevent other STIs or replace emergency PEP.

Clinical reference

Dose options

Start PrEP, weight ≥35 kg

Day 1: 927 mg SC as two 1.5-mL injections plus 600 mg orally; day 2: 600 mg orally

Tablets may be taken with or without food.

Continue

927 mg SC every 26 weeks, with a ±2-week window

Delayed doses need a prescribed bridge or restart plan; consult the current label.

Before prescribing

Exclude HIV and review all interactions. Obtain baseline laboratory Ag/Ab and confirmatory RNA; test before subsequent injections using the current algorithm. Ensure HBV treatment continues if switching off tenofovir. Discuss pregnancy individually.

Side effects and return precautions

Injection nodules and pain; serious local reactions are possible. Unrecognized HIV or missed dosing risks resistance. Interactions can require supplemental doses; do not use a routine schedule without medication review.

Follow-up

Schedule injections and HIV testing; provide interim STI screening. If stopping with ongoing exposure risk, initiate alternative PrEP within 28 weeks of the last injection. Do not assume residual drug provides continued protection.

Sources

Checked September 23, 2026.

Levofloxacin (Levaquin)Pneumonia with other illnesses or allergy

What to say

You have pneumonia, an infection in the lungs. Because of your [other health conditions or allergy], we’re using levofloxacin. Take 750 milligrams once a day for 5 days, with or without food. Take it at least 2 hours before or after antacids, sucralfate, iron, zinc or multivitamins. Most people improve within 2 to 3 days; cough can last weeks.

Rarely, it harms tendons, nerves or mood. Stop it and call us the same day for tendon pain or swelling, new numbness or tingling, or changes in mood or thinking. It can make blood sugar run low or high; check it more often if you use diabetes medicine. Call if you aren’t improving after 3 days or have severe watery diarrhea. Go to the emergency department for worsening breathing or new confusion. Call 911 for fainting, sudden severe chest, belly or back pain, severe trouble breathing, or face or tongue swelling.

Clinical reference

Dose options

Outpatient CAP with comorbidities (ATS/IDSA 2019 monotherapy option)

750 mg orally once daily for 5 days (CrCl ≥50 mL/min)

Strong recommendation for adults with chronic heart, lung, liver or renal disease, diabetes, alcohol use disorder, malignancy or asplenia; the label also allows 500 mg daily for 7–14 days. Treat ≥5 days and until clinically stable. Healthy adults with beta-lactam allergy: doxycycline, or a macrolide where pneumococcal macrolide resistance is <25%.

Renal adjustment

CrCl 20–49 mL/min: 750 mg every 48 hours; CrCl 10–19, hemodialysis or CAPD: 750 mg once, then 500 mg every 48 hours

Per label. Take with or without food; separate from Mg/Al antacids, sucralfate, iron and zinc-containing multivitamins by ≥2 hours.

Before prescribing

Confirm outpatient-appropriate CAP. Boxed warnings: tendinopathy (age >60, steroids, transplant), neuropathy, CNS effects; avoid in myasthenia gravis. Avoid with aortic aneurysm risk, QT prolongation, hypokalemia or QT drugs. Check CrCl, diabetes drugs, warfarin, pregnancy and recent fluoroquinolone use.

Side effects and return precautions

Tendinitis/rupture, neuropathy, psychiatric effects, dysglycemia including hypoglycemic coma, QT prolongation, aortic aneurysm/dissection, photosensitivity, C. difficile and hypersensitivity. Stop at the first sign of tendon, nerve or CNS effects.

Follow-up

Contact at 48–72 hours. Stop after 5 days if clinically stable. Not stable by day 5: assess for resistance, empyema, abscess or another diagnosis. No routine follow-up chest imaging if symptoms resolve within 5–7 days.

Sources

Checked October 15, 2026.

Levonorgestrel 1.5 mg (Plan B One-Step)Emergency contraception

What to say

After sex without birth control or a condom failure, take 1 levonorgestrel 1.5 milligram tablet (Plan B One-Step or a store brand) as soon as possible. It works best within 3 days but may help up to 5 days. Anyone can buy it without a prescription. If you vomit within 3 hours, ask us or a pharmacist about repeating it. It won’t end an existing pregnancy. After 3 days, or at a higher body weight, ella or a copper IUD works better.

It won’t protect you if you have sex again, so start regular birth control now and use condoms or avoid sex for 7 days. Nausea, headache, tiredness or spotting can happen, and your period may come early or late. Take a pregnancy test if it’s more than a week late. Severe lower belly pain or fainting needs emergency care. Seizure medicines, rifampin, efavirenz and St. John’s wort can weaken it. We can also test for sexually transmitted infections.

Clinical reference

Dose options

Emergency contraception

Levonorgestrel 1.5 mg orally once, as soon as possible after unprotected sex

Label: within 72 hours. CDC SPR 2024: ECPs as soon as possible within 5 days; ulipristal is more effective on days 3–5, and a Cu-IUD is most effective.

Vomiting after the dose

Within 3 hours: repeat the dose as soon as possible (CDC)

The OTC label uses 2 hours and says to ask a clinician; consider an antiemetic.

Starting regular contraception

Start or resume any method immediately; condoms or abstinence for 7 days

Not a regular method. Pregnancy test if no withdrawal bleed within 3 weeks.

Before prescribing

Ask about all unprotected sex since the last period. Prefer ulipristal or a Cu-IUD after 72 hours or with obesity, and a Cu-IUD with enzyme inducers (anticonvulsants, rifampin, efavirenz, St. John’s wort). Not within 5 days after ulipristal.

Side effects and return precautions

Nausea, headache, fatigue, breast pain, abdominal pain, dizziness and cycle changes. Severe pelvic pain or syncope after use needs urgent assessment for ectopic pregnancy.

Follow-up

Pregnancy test if menses are over a week late or absent at 3 weeks. Arrange ongoing contraception and advance EC. Offer STI testing; assess nPEP within 72 hours of HIV exposure.

Sources

Checked October 15, 2026.

Levothyroxine (Synthroid, Levoxyl, Unithroid)Hypothyroidism

What to say

Your thyroid isn’t making enough hormone, so we’ll replace what is missing with levothyroxine [dose] micrograms every day. Take it with water on an empty stomach, 30 to 60 minutes before breakfast. Keep iron and calcium supplements at least four hours away.

Energy and other symptoms may improve over weeks. We’ll check the thyroid blood test in about six to eight weeks and adjust in small steps. Taking extra won’t safely speed things up. Tell me about a racing heartbeat, shaking or feeling unusually hot. For chest pain or fainting, call 911. Tell us if you change the product, start an acid medicine or use biotin, a supplement often found in hair-and-nail products. If you become pregnant, keep taking your thyroid medicine and contact us promptly because you may need an early dose adjustment.

Clinical reference

Dose options

Full replacement when appropriate

Approximately 1.6 micrograms/kg/day in a healthy nonelderly adult

Individualize for severity, residual function and body size; not a default for older/cardiac patients.

Conservative start

12.5–25 micrograms daily in older/cardiac patients

Use slower titration; other partial-replacement doses depend on the clinical context.

Adjustment / dose review

12.5–25-microgram increments, generally every 4–6 weeks; slower 6–8 weeks in older/cardiac patients

No universal maximum. >200 micrograms/day is seldom needed; very high needs warrant adherence, absorption and interaction review.

Before prescribing

Check TSH/free T4 and primary versus central disease, cardiac history, adrenal insufficiency concerns, pregnancy and absorption/interactions. Use micrograms, not milligrams, in the prescription.

Side effects and return precautions

Over-replacement can cause palpitations, tremor, insomnia and cardiac/bone harm. PPI-related absorption issues are not reliably solved by spacing alone. Biotin can interfere with laboratory assays.

Follow-up

TSH about 6–8 weeks after changes, then generally 6–12 months when stable. Pregnancy needs prompt dose planning and more frequent testing, often every four weeks until stable.

Sources

Checked September 20, 2026.

Lidocaine 4% or 5% patch (Lidoderm)Localized pain

What to say

A lidocaine patch numbs the skin to ease pain in one area. The prescription 5% patch is approved for nerve pain after shingles; other uses are off-label. Apply up to 3 patches to clean, unbroken skin over the painful area: 12 hours on, then 12 hours off. You can cut patches to size before removing the backing. Over-the-counter 4% patches have different limits, so follow the package.

Redness, itching or burning can happen; remove the patch until the skin settles. Don’t put a heating pad or electric blanket over a patch, and wash your hands after handling one. Used patches still contain a lot of medicine: fold them sticky sides together and discard them where children and pets can’t reach. If a child chews one, call Poison Control at 1-800-222-1222 or 911. Get emergency care for gray or blue skin, a racing heartbeat or shortness of breath.

Clinical reference

Dose options

Lidoderm 5% (Rx): postherpetic neuralgia

Up to 3 patches at once for up to 12 hours within any 24 hours

May be cut before removing the liner. Use smaller areas with debility or impaired elimination. Other localized pain is off-label.

OTC lidocaine 4% patches

Follow the product’s Drug Facts; one example: 1 patch at a time, no more than 1 per 8 hours, maximum 3 per day

For ages 12 and older; stop and seek care if pain lasts more than 7 days. Don’t combine with other topical anesthetics or analgesics.

  • Lidoderm 5% is FDA-labeled only for postherpetic neuralgia; other uses are off-label. OTC 4% patches are labeled for temporary relief of minor localized pain.

Before prescribing

Confirm localized pain over intact skin. Review amide anesthetic allergy, class I antiarrhythmics (e.g., mexiletine), other local anesthetics, methemoglobinemia risk (G6PD deficiency, nitrates), severe hepatic disease, and children or pets at home.

Side effects and return precautions

Application-site erythema, burning or pruritus. Extra patches, longer wear, heat or broken skin raise absorption; watch for lidocaine toxicity and methemoglobinemia (cyanosis, tachycardia, dyspnea).

Follow-up

Review benefit in 1–2 weeks and stop if there is no clear relief. Reassess the diagnosis and other treatments for persistent focal pain.

Sources

Checked October 15, 2026.

Linaclotide (Linzess)IBS with constipation

What to say

Linaclotide draws water into the bowel to soften stool and speed it along, and it can ease IBS belly pain. Take one capsule daily on an empty stomach, at least 30 minutes before a meal, at about the same time each day: 290 micrograms for IBS with constipation, or 145 or 72 micrograms for chronic constipation. Swallow it whole, or ask us about mixing it with applesauce. If you miss a dose, skip it. Stools often improve in the first week; pain can take several weeks.

Diarrhea is the most common side effect, usually in the first 2 weeks. Gas or bloating can also happen. Stop it and call us the same day for severe diarrhea, severe or unusual belly pain, or bloody or black stools. Dizziness or fainting with diarrhea means go to the emergency department. Keep it in its original bottle with the drying packet, away from children. Tell us if cost or insurance approval is a problem.

Clinical reference

Dose options

IBS with constipation

290 mcg orally once daily, at least 30 minutes before a meal

ACG 2021 recommends GC-C agonists for global IBS-C symptoms (strong recommendation, high-quality evidence).

Chronic idiopathic constipation

145 mcg once daily; 72 mcg once daily based on presentation or tolerability

AGA/ACG 2023 strongly recommends linaclotide when OTC agents fail, as a replacement or add-on.

Administration

Swallow whole, or open onto 1 teaspoon of applesauce or into 30 mL of bottled water and take at once

Don’t crush or chew the beads. Missed dose: skip it. Keep in the original container with the desiccant. Contraindicated under age 2, so store away from children.

Before prescribing

Confirm IBS-C or CIC and exclude mechanical obstruction and alarm features. Consider volume-depletion risk (diuretics, older age) and other laxatives. Check coverage or prior authorization.

Side effects and return precautions

Diarrhea in 20% vs 3% with placebo in IBS-C trials (severe in 2%), mostly within 2 weeks; severe cases with syncope, hypotension, hypokalemia or hyponatremia reported. Abdominal pain, flatulence, distension.

Follow-up

Review diarrhea and stool pattern within 2 weeks; IBS pain benefit builds over weeks (peak around weeks 6–9 in trials). For CIC, consider 72 mcg if diarrhea limits use; suspend for severe diarrhea.

Sources

Checked October 15, 2026.

Liraglutide (Saxenda)Weight management

What to say

Liraglutide is a daily injection that reduces appetite and helps with weight loss alongside changes in eating and activity. Inject it under the skin once a day, at any time, with or without meals. Start with 0.6 milligrams daily for 1 week, then increase by 0.6 milligrams each week until you reach 3 milligrams daily. If you miss more than 3 days, call us; you’ll restart at the low dose.

Nausea, diarrhea, constipation and vomiting are common. Call the same day if you can’t keep fluids down. Severe belly pain that won’t go away, with or without vomiting, means stop it and go to the emergency department. Call us for upper right belly pain, yellow eyes, or a racing heartbeat at rest. Tell us about medullary thyroid cancer or MEN2 in you or your family, or upcoming anesthesia. Stop it if you become pregnant.

Clinical reference

Dose options

Weight management (Saxenda or generic 3 mg product)

0.6 mg SC daily for 1 week, then 1.2, 1.8 and 2.4 mg in weekly steps; 3 mg daily from week 5

Delay a step about 1 week if not tolerated; stop if 3 mg isn’t tolerated. Stop if <4% weight loss at 16 weeks. Missed >3 days: restart at 0.6 mg.

Product differences

Victoza and its generics (type 2 diabetes) max 1.8 mg daily

Don’t combine with any other GLP-1 RA. Confirm the pen matches the weight-management product.

  • Generic liraglutide 3 mg products carry the weight-management indication and usually cost less; other generics copy Victoza (diabetes, max 1.8 mg).

Before prescribing

Contraindicated: personal/family history of MTC or MEN2, serious hypersensitivity. Ask about pancreatitis, gallbladder disease, pregnancy plans, insulin or sulfonylurea (hypoglycemia) and planned anesthesia. Eligibility: BMI ≥30, or ≥27 with a weight-related condition.

Side effects and return precautions

GI effects, dehydration and acute kidney injury, pancreatitis, gallbladder disease, resting heart-rate rise, hypoglycemia with insulin or sulfonylureas, hypersensitivity, aspiration risk with anesthesia.

Follow-up

Review tolerance during titration; check weight, BP and glucose at 16 weeks and stop if <4% loss. Expect less weight loss than semaglutide or tirzepatide; consider switching if goals aren’t met.

Sources

Checked October 15, 2026.

Lisdexamfetamine (Vyvanse)ADHD

What to say

For ADHD, start lisdexamfetamine 30 milligrams once each morning, with or without food. Swallow the capsule whole, or stir all the powder into yogurt, water or orange juice and take it right away. Chew chewable tablets completely. Don’t split a dose. If you forget until the afternoon, skip that day’s dose. We may raise it by 10 or 20 milligrams about weekly, up to 70 milligrams, based on benefit and side effects.

Less appetite, dry mouth, trouble sleeping, anxiety and a faster pulse are common. Tell us if fingers or toes turn pale, blue or painful. Chest pain, fainting or severe shortness of breath means call 911. Call the same day for hallucinations, a major mood change, or very high energy with little sleep. Check with us before starting antidepressants, migraine medicines or tramadol. Keep it locked up and never share it; each fill needs a new prescription. We’ll check your blood pressure, pulse, weight and progress within two weeks.

Clinical reference

Dose options

Adult ADHD

30 mg orally each morning; adjust by 10–20 mg at about weekly intervals; maximum 70 mg/day

Swallow the capsule whole or mix all contents in yogurt, water or orange juice and take at once; chewables (10–60 mg) must be chewed. Capsule and chewable convert mg for mg. Avoid afternoon dosing; never divide a dose.

Renal impairment / interactions

GFR 15–<30: maximum 50 mg/day; GFR <15 (ESRD): maximum 30 mg/day

Not dialyzable. Start lower and monitor with serotonergic drugs or CYP2D6 inhibitors. Urinary alkalinizers raise levels (avoid); acidifiers lower them. Start at the low end in older adults.

  • Generic lisdexamfetamine capsules and chewable tablets are available; there is no 70-mg chewable.

Before prescribing

Confirm ADHD with current impairment. Assess BP/pulse, weight, serious heart disease (avoid), family sudden death, bipolar/psychosis, tics and misuse/diversion risk. No MAOIs within 14 days. Schedule II: check CURES first, then at least every 6 months; no refills.

Side effects and return precautions

Boxed warning: abuse, misuse and addiction. Appetite/weight loss, insomnia, BP/HR rise, anxiety; mania or psychosis, Raynaud/digital ulcers, tics, serotonin syndrome. Chest pain or syncope needs emergency evaluation.

Follow-up

Review benefit and adverse effects at each titration step. BP/pulse before and after each dose change and every 6 months; weight every 6 months (NICE). No routine ECG or labs unless indicated.

Sources

Checked October 15, 2026.

Lisdexamfetamine (Vyvanse)Binge-eating disorder

What to say

For binge-eating disorder, we’re adding lisdexamfetamine to eating-focused therapy, which remains the core treatment. Start 30 milligrams once each morning, with or without food. Swallow the capsule whole, or stir all the powder into yogurt, water or orange juice and take it right away. We’ll usually increase by 20 milligrams about once a week toward 50 to 70 milligrams. It isn’t a weight-loss medicine, and we’ll stop it if binge eating doesn’t improve.

Dry mouth, trouble sleeping, less appetite, constipation, feeling jittery and a faster heartbeat are common. Chest pain, fainting or severe shortness of breath means call 911. Call the same day for hallucinations, a major mood change, or very high energy with little sleep. Tell us if you start skipping meals, vomiting or using the medicine to control weight. Keep it locked up and never share it; each fill needs a new prescription. We’ll check your binge days, blood pressure and pulse within two weeks.

Clinical reference

Dose options

Adult moderate to severe BED

30 mg each morning; increase by 20 mg at about weekly intervals to 50–70 mg/day; maximum 70 mg/day

30 mg is a titration step: it did not separate from placebo in a fixed-dose trial. Stop if binge eating does not improve. Not for weight loss; obesity efficacy and safety not established.

Renal impairment / administration

GFR 15–<30: maximum 50 mg/day; GFR <15: maximum 30 mg/day

Capsule whole or contents in yogurt, water or orange juice; chewables chewed thoroughly. Avoid afternoon doses. Same interaction cautions as ADHD use.

  • APA 2023: eating disorder–focused CBT or IPT recommended (1C); lisdexamfetamine or an antidepressant suggested (2C) for adults who prefer medication or don’t respond to psychotherapy alone.

Before prescribing

Confirm BED rather than bulimia or anorexia; ask about restriction, purging and stimulant misuse. Assess cardiac history, BP/pulse, bipolar/psychosis and substance use. No MAOIs within 14 days. Schedule II: check CURES first and every 6 months.

Side effects and return precautions

Boxed warning: abuse, misuse and addiction; misuse for appetite suppression is a particular risk. Insomnia, dry mouth, HR/BP rise, anxiety, mania or psychosis, Raynaud, serotonin syndrome. New restriction or purging needs prompt review.

Follow-up

Track binge days per week, BP/HR and weight at each step; stop if no response. Continue CBT or IPT. Trials enrolled ages 18–55 without cardiovascular risk beyond obesity or smoking.

Sources

Checked October 15, 2026.

Lisinopril (Zestril, Prinivil)Heart failure with reduced ejection fraction

What to say

As part of your heart-failure plan, start lisinopril 5 milligrams once daily. It reduces strain on the heart. We’ll check blood pressure, kidney function and potassium before increasing it. Some people need a lower starting dose. Continue the other medicines in your agreed heart-failure plan.

A dry cough or dizziness can occur. Don’t add potassium supplements, potassium salt substitutes or ibuprofen without checking. Stop it and call 911 for swelling of the lips or tongue or trouble breathing. Stop it and contact us immediately if pregnancy occurs. Call if vomiting or diarrhea prevents normal drinking, or if breathlessness or swelling is increasing.

Clinical reference

Dose options

Stable systolic heart failure

Start 5 mg once daily; increase as tolerated up to 40 mg/day

Start 2.5 mg with serum sodium <130 mEq/L; renal impairment and hypotension risk may also require a lower start.

Renal function

CrCl 10–30: halve the usual starting dose; CrCl <10 or dialysis: 2.5 mg daily initially

Monitor creatinine and potassium after starting or increasing; adjust to clinical response.

Before prescribing

Confirm HFrEF and why an ACE inhibitor is chosen rather than an ARNI. Check volume status, BP, sodium, creatinine, potassium, pregnancy, angioedema history and interacting drugs. Do not combine with an ARB or sacubitril/valsartan; allow at least 36 hours between ACE inhibitor and sacubitril/valsartan.

Side effects and return precautions

Common: dizziness, dry cough. Important: angioedema, hyperkalemia and kidney injury. Facial/tongue swelling requires stopping and emergency assessment; dehydration needs an individualized hold/restart plan.

Follow-up

Review BP, creatinine and potassium in 1–2 weeks after initiation and each titration, sooner if high risk. Track symptoms and weight alongside the full HFrEF regimen.

Sources

Checked September 23, 2026.

Lisinopril (Zestril, Prinivil)Hypertension

What to say

I’m starting lisinopril 10 milligrams once a day to lower your blood pressure and reduce the strain on your blood vessels over time. Take it at a time you can remember, with or without food. You may not feel any different when it’s working.

You may feel lightheaded at first, so get up slowly. A dry cough can happen. Tell me if it persists and we can discuss another medicine. If your lips or tongue swell or breathing becomes difficult, stop it and call 911. We’ll check kidney function and potassium in about two weeks and review your home readings. Call the same day if vomiting or diarrhea prevents you from drinking normally. If you become pregnant, stop it and contact us immediately.

Clinical reference

Dose options

Usual start

10 mg orally once daily

Hypertension; choose lower starting dose when indicated.

Usual range

20–40 mg once daily

Titrate to BP and tolerance. Doses up to 80 mg have been used without greater effect, so 40 mg is the usual ceiling for hypertension.

Lower starting dose

5 mg daily with a diuretic or CrCl 10–30; 2.5 mg if CrCl <10 or hemodialysis

Assess volume status and follow the current product label.

Before prescribing

Check BP, creatinine/eGFR, potassium, pregnancy plans and angioedema history. Review potassium products, ARBs/aliskiren, sacubitril/valsartan timing, NSAIDs and volume depletion.

Side effects and return precautions

Common: dizziness, dry cough. Important: angioedema, hyperkalemia and kidney injury. Facial/tongue swelling requires stopping and emergency assessment; dehydration needs an individualized hold/restart plan.

Follow-up

BP and creatinine/potassium within 2–4 weeks after starting or increasing, earlier for higher risk. The two-week check in the wording above is one option within that window.

Sources

Checked September 20, 2026.

Lisinopril (Zestril, Prinivil)Treatment after a heart attack

What to say

Lisinopril was started as part of your heart-attack treatment to improve survival. Continue [prescribed dose] once daily from your discharge list. We’ll check blood pressure, kidney function and potassium and decide with your heart team how long to continue it. Don’t restart the hospital’s first-dose sequence at home.

A dry cough or dizziness may occur. Call if these are troublesome or if vomiting or diarrhea prevents normal drinking. Check before adding potassium, salt substitutes or anti-inflammatory pain medicines. Stop it and call 911 for swelling of the lips or tongue or trouble breathing. If pregnancy occurs, stop it and contact us immediately. New chest pain, fainting or severe breathlessness needs 911.

Clinical reference

Dose options

Monitored acute-MI initiation, hemodynamically stable

Within 24 hours of symptom onset: 5 mg initially, 5 mg 24 hours later, 10 mg at 48 hours, then 10 mg daily

Continue for at least 6 weeks per label. Reassess ongoing indications after that; six weeks is not an automatic stop date. This is an acute-care sequence, not home treatment for suspected MI.

Low BP or reduced renal function

Initial 2.5 mg when SBP is >100 to ≤120 mmHg in the first 3 days, or with CrCl 10–30; CrCl <10/dialysis also starts at 2.5 mg

The treating team must adjust for hypotension/renal change. Do not apply standard dosing to an unstable patient.

Before prescribing

Reconcile discharge timing/dose, BP, creatinine, potassium and cardiology plan. Check pregnancy and ACE-inhibitor, hereditary or idiopathic angioedema history. Avoid ACE/ARB duplication; allow ≥36 hours when switching to or from sacubitril/valsartan. Aliskiren with diabetes is contraindicated.

Side effects and return precautions

Cough, hypotension, hyperkalemia, renal injury and angioedema. Symptomatic low BP needs prompt assessment; persistent severe hypotension requires withdrawal under the treating team.

Follow-up

Arrange early post-discharge review and a dated creatinine/potassium check, usually within 1–2 weeks or sooner for higher risk and after titration. Reassess duration with cardiology, especially if LV dysfunction persists.

Sources

Checked September 23, 2026.

Lithium carbonate (Lithobid)Bipolar disorder

What to say

Lithium helps prevent manic and depressive episodes. Take [dose] at the same times each day; swallow extended-release tablets whole. Blood levels guide your dose. Have them drawn before your morning dose, about 12 hours after the last one, five days after any dose change, then every few months. We’ll check kidney, thyroid and calcium tests too. Don’t double up after a missed dose, and don’t stop or change the dose on your own.

Thirst, passing more urine, a fine hand tremor and weight gain are common. Drink fluids regularly and keep your salt intake steady. For vomiting or diarrhea, hold your dose and call us the same day; call too for fever or heavy sweating. Stop it and call right away for worsening shakiness, unsteadiness, slurred speech, drowsiness or weakness. Confusion, fainting or a seizure means call 911. Check with us before ibuprofen, naproxen, water pills or new blood pressure medicines. If you could become pregnant, let’s plan ahead.

Clinical reference

Dose options

Maintenance dosing

Individualized to trough levels; often 900–1,200 mg/day in divided doses

Generic immediate-release label: start 300 mg three times daily, increase by 300 mg every 3 days; maintenance 300–600 mg two to three times daily. Lithobid (300-mg ER) is swallowed whole. Start lower in older adults and at CrCl 30–89; not recommended below 30.

Maintenance trough target

0.6–0.8 mmol/L (= mEq/L); 0.4–0.6 if good response but poor tolerance; 0.8–1.0 if response is insufficient

ISBD/IGSLi 2019 consensus. CANMAT/ISBD 2018: 0.6–1.0 may suffice (acute 0.8–1.2; lower in older adults). Labels differ: generic 0.8–1.0, Lithobid 0.6–1.2. Toxicity at ≥1.5 and sometimes lower.

Level timing

Trough 12 hours after the last dose; about 5 days after each change; every 3–6 months once stable

Recheck with dehydration, febrile illness, or starting or stopping NSAIDs, diuretics, ACEi/ARBs, metronidazole or SGLT2 inhibitors. The Lithobid label says at least every 2 months in maintenance.

  • Lithium is dangerous in overdose; weigh supply size when suicide risk is high, and plan any discontinuation gradually with psychiatry.

Before prescribing

Baseline creatinine/eGFR, electrolytes, calcium, TSH, urinalysis, weight and pregnancy status; ECG if over 40 or cardiac risk. Avoid in known or suspected Brugada syndrome; get cardiology input for unexplained syncope. Review interacting drugs and overdose risk.

Side effects and return precautions

Toxicity can occur near therapeutic levels: GI upset, coarse tremor, ataxia, drowsiness or confusion means hold, check a level and assess urgently. Polyuria/nephrogenic DI, hypothyroidism, hypercalcemia/hyperparathyroidism, CKD, hyponatremia, serotonin syndrome.

Follow-up

Level about 5 days after any change, then every 3–6 months; eGFR, TSH and calcium at 6 months, then at least yearly (label: TSH at 3 months, then every 6–12 months). Coordinate changes with psychiatry.

Sources

Checked October 15, 2026.

Loperamide (Imodium A-D)Diarrhea

What to say

Loperamide slows the gut to reduce loose stools, though it doesn’t treat the cause. For watery diarrhea without blood or fever, take 4 milligrams (two 2-milligram tablets) after the first loose stool, then 2 milligrams after each later one. Don’t take more than 8 milligrams in 24 hours unless we set a different limit. Stop once stools firm up, and keep drinking fluids such as broth or an oral rehydration drink. For IBS with diarrhea, we’ll set your usual dose.

Constipation, bloating or drowsiness can happen. Taking more than directed, or with certain prescription medicines, can cause dangerous heart rhythm problems, so check with us or a pharmacist first. Don’t use it for bloody or black stools, fever, or diarrhea after antibiotics; call us instead. Stop it and call the same day if diarrhea lasts more than 2 days or worsens, your belly swells, or you’re dizzy and barely urinating. Fainting or a racing or irregular heartbeat means call 911.

Clinical reference

Dose options

Acute diarrhea, self-treatment

4 mg after the first loose stool, then 2 mg after each later loose stool; maximum 8 mg in 24 hours, for no more than 2 days

Drug Facts dosing; ACG 2016 gives the same dose and limits use to 48 hours. ACG also supports adding loperamide to antibiotics for travelers’ diarrhea.

Clinician-directed maximum

Up to 16 mg/day (prescription labeling); chronic diarrhea maintenance averaged 4–8 mg/day in trials

Boxed warning: torsades de pointes, cardiac arrest and death with higher-than-recommended doses. Acute diarrhea usually improves within 48 hours.

IBS with diarrhea

As-needed or scheduled doses individualized within the 16 mg/day limit

AGA 2022 suggests loperamide for IBS-D (conditional, very low certainty). ACG 2021: it may improve diarrhea but not global IBS symptoms.

  • Labeled for acute diarrhea, IBD-associated chronic diarrhea and ileostomy output; scheduled IBS-D use is guideline-supported but should be clinician-directed.

Before prescribing

Exclude bloody stool, fever, suspected C. difficile or recent antibiotics, and abdominal pain without diarrhea. Review QT-prolonging drugs, CYP3A4/CYP2C8/P-gp inhibitors (itraconazole, gemfibrozil, ritonavir, quinidine), arrhythmia history, older age, hepatic impairment and misuse risk.

Side effects and return precautions

Constipation, distension or ileus (stop it); drowsiness or dizziness. Syncope, palpitations or ventricular arrhythmia suggest toxicity, often from high-dose misuse. Avoid in inflammatory colitis because of toxic megacolon risk.

Follow-up

Reassess acute diarrhea lasting more than 48 hours or any red flag, with stool testing when indicated. For IBS-D, review stool frequency, urgency and rebound constipation, and document a daily maximum.

Sources

Checked October 15, 2026.

Lorazepam (Ativan)Short-term severe anxiety

What to say

For this short period of severe anxiety, we’ve agreed on lorazepam 0.5 milligrams up to twice a day only if needed, through [stop or review date]. This is a temporary part of the plan while we address the cause and arrange the longer-term treatment.

It can make you sleepy, unsteady or less alert. Don’t drive, drink alcohol or combine it with opioids or other sedatives unless we have specifically planned that combination. Keep it secure and don’t share it. Hold the next dose and call the same day if you become unusually agitated, confused or excessively sleepy. If someone is hard to wake or breathing slowly, call 911. Regular use can cause physical dependence. Don’t abruptly stop after taking it regularly, because withdrawal can cause seizures. We’ll review how often you used it and whether it helped before any extension.

Clinical reference

Dose options

Brief anxiety course

0.5 mg orally up to twice daily as needed, with an explicit review/stop date

A conservative individualized plan; not routine ongoing treatment for GAD.

Adult label schedules

For anxiety, initial 2–3 mg/day divided; usual total 2–6 mg/day, range 1–10 mg/day

Dose must be individualized; higher label ranges are not default targets. Use the lowest effective dose and duration.

Older/debilitated patients

Label initial total 1–2 mg/day divided; often avoid or choose a lower clinical start because of falls/delirium risk

Renal/hepatic disease and respiratory vulnerability require caution. Taper after regular use according to dependence risk, not a fixed universal schedule.

Before prescribing

Assess acute anxiety cause, suicidality, alcohol/opioid/sedative use, respiratory disease/sleep apnea, falls, pregnancy and dependence history. Review controlled-prescription history and a concrete short-term indication. Consider alternatives and withdrawal risk before any change.

Side effects and return precautions

Sedation, ataxia and memory impairment; paradoxical agitation, misuse/addiction and dangerous respiratory depression with other depressants. Severe withdrawal can include delirium or seizure; emergency assessment is required.

Follow-up

Review within days to 1–2 weeks for a brief course, before renewal. Track frequency, function and sedation; if use becomes regular, agree on a gradual taper and treatment of the underlying disorder.

Sources

Checked September 20, 2026.

Losartan (Cozaar)Diabetic kidney disease with hypertension

What to say

Because diabetes and high blood pressure are affecting your kidneys, we’re using losartan to lower pressure and help slow kidney damage. Start 50 milligrams once daily. We’ll check kidney function and potassium and may increase it if your blood pressure and results allow.

You may feel lightheaded, especially when dehydrated. Check before taking potassium supplements, potassium salt substitutes or anti-inflammatory pain medicines such as ibuprofen. Call for advice if vomiting or diarrhea prevents normal drinking. Stop it and contact us immediately if pregnancy occurs. Trouble breathing or swelling of the tongue means call 911.

Clinical reference

Dose options

Labeled diabetic nephropathy population

50 mg once daily; increase to 100 mg daily according to BP response and tolerance

Label population: type 2 diabetes, hypertension, elevated creatinine and proteinuria ≥300 mg/g. Consider 25 mg initially with volume depletion or mild–moderate hepatic impairment.

Before prescribing

Check diabetes type, BP, albuminuria/proteinuria, creatinine, potassium, volume status, pregnancy and interacting medicines. Avoid dual renin–angiotensin blockade; review other indicated kidney-protective therapy.

Side effects and return precautions

Common: dizziness. Important: hyperkalemia, renal dysfunction, fetal harm and rare angioedema. Do not imply ARBs are free of angioedema risk.

Follow-up

Recheck BP, creatinine and potassium in 1–2 weeks after starting or increasing, sooner if high risk. Follow urine albumin and kidney-function trends; do not judge renal protection by symptoms alone.

Sources

Checked September 23, 2026.

Losartan (Cozaar)Hypertension

What to say

Losartan helps relax the blood vessels so the pressure comes down. I’m starting 50 milligrams once daily. It can be taken with or without food, and the full effect builds over several weeks.

Keep a home blood-pressure log. If you feel dizzy, sit down and tell me if it keeps happening. We’ll check kidney function and potassium in about two weeks, because those can change without symptoms. Check with us before adding potassium supplements, potassium-based salt substitutes, ibuprofen or naproxen. Call the same day if you can’t drink normally or are passing much less urine. Stop it and contact us immediately if you become pregnant. If your tongue swells or breathing becomes difficult, stop it and call 911.

Clinical reference

Dose options

Usual start

50 mg orally once daily

Hypertension.

Lower start

25 mg once daily

Possible intravascular depletion or mild–moderate hepatic impairment.

Higher dose

Up to 100 mg once daily

Increase according to BP and tolerance; no fixed label titration interval.

Before prescribing

Check BP, creatinine/eGFR and potassium; review pregnancy, volume depletion, renal artery disease and interacting medicines. No routine renal starting-dose adjustment solely for reduced function, but depletion/risk changes management.

Side effects and return precautions

Common: dizziness. Important: hyperkalemia, renal dysfunction, fetal harm and rare angioedema. Do not imply ARBs are free of angioedema risk.

Follow-up

Recheck BP and creatinine/potassium within 2–4 weeks of initiation or dose change, earlier if risk or symptoms warrant. Give a dehydration hold/restart plan.

Sources

Checked September 20, 2026.

Losartan/hydrochlorothiazide (Hyzaar)Hypertension

What to say

This single pill combines 2 blood pressure medicines: losartan, which relaxes blood vessels, and hydrochlorothiazide, a water pill. Two medicines in 1 pill usually control blood pressure better and keep your routine simple. Take [dose] once each morning, with or without food. We may increase it after about 3 weeks. Share your home blood pressure readings. We’ll check kidney function, potassium and sodium in 2 to 4 weeks.

You may pee more or feel dizzy when you stand; tell us if dizziness keeps happening. If you’re vomiting, have diarrhea or can’t drink normally, call us the same day about pausing it. Avoid ibuprofen, naproxen, potassium pills and salt substitutes unless we approve. It can trigger gout and make sunburn more likely, so use sun protection. Sudden eye pain or blurry vision means stop it and get emergency eye care. Stop it and call us right away if you become pregnant. Swelling of your lips, tongue or throat means call 911.

Clinical reference

Dose options

Stage 2 hypertension or uncontrolled on 1 drug

50/12.5 mg once daily; after about 3 weeks may increase to 100/25 mg (maximum)

The 2025 AHA/ACC guideline recommends starting stage 2 hypertension with 2 first-line drugs, preferably in 1 pill; the label limits first-line use of the combination to hypertension severe enough to need prompt control.

Other steps

100/12.5 mg if uncontrolled on losartan 100 mg, then 100/25 mg

Don’t start with volume depletion or hepatic impairment (losartan 25 mg start needed). Not established for CrCl <30; contraindicated in anuria.

Before prescribing

Confirm stage 2 BP with home or ambulatory readings. Check eGFR, K, Na, Ca, uric acid and glucose; review pregnancy potential (boxed fetal toxicity), sulfonamide reactions, lithium, NSAIDs and other RAS blockers.

Side effects and return precautions

Dizziness and orthostasis, hypo- or hyperkalemia, hyponatremia, AKI with volume depletion or NSAIDs, gout, photosensitivity and nonmelanoma skin cancer, acute myopia or angle-closure glaucoma, angioedema.

Follow-up

Recheck BP, creatinine, K and Na 2–4 weeks after starting or titrating, then periodically. Titrate toward the BP goal (generally <130/80) and add a third first-line agent if needed.

Sources

Checked October 15, 2026.

Meclizine (Antivert)Vertigo

What to say

Meclizine can ease spinning and nausea from an inner-ear problem. Take [12.5 or 25] milligrams up to 3 times a day when needed, no more than 100 milligrams a day. Use it on the worst days only, usually no more than 3 days, because it can slow your brain’s natural recovery. It doesn’t fix positional vertigo; repositioning maneuvers do. As the spinning settles, move your head and walk normally again.

Drowsiness, dry mouth and blurred vision are common. Don’t drive until you know how it affects you, and avoid alcohol and other sedating medicines. Older adults can become confused or fall, so get up slowly. Call us if you can’t pass urine, have eye pain or aren’t improving within [3 days], and the same day for sudden hearing loss in one ear. Call 911 for dizziness with new weakness, numbness, double vision, trouble speaking or swallowing, a severe headache, or if you can’t walk.

Clinical reference

Dose options

Acute vestibular vertigo, short term

12.5–25 mg orally up to every 8 hours as needed; label range 25–100 mg/day in divided doses

Limit to a few days: vestibular suppressants impair central compensation (AAFP). Older adults: avoid if possible, or start 12.5 mg.

BPPV

Not routinely recommended (AAO-HNS 2017)

Treat with a canalith repositioning maneuver; suppressants don’t treat BPPV and add fall risk.

Formulations

Swallow tablets whole; chew chewable tablets completely

Also sold over the counter for motion sickness; the prescription label covers vertigo of vestibular origin in adults.

Before prescribing

Distinguish peripheral from central vertigo (neurologic exam, gait, HINTS when trained) before treating. Check glaucoma, asthma, BPH/urinary retention, age (Beers: avoid first-generation antihistamines), sedatives/alcohol, CYP2D6 inhibitors and hepatic/renal impairment.

Side effects and return precautions

Drowsiness, dry mouth, blurred vision, fatigue, headache; anticholinergic confusion, urinary retention and falls. Rare anaphylaxis. Focal deficits or inability to walk need emergency evaluation.

Follow-up

Reassess within a few days if vertigo persists; stop meclizine as symptoms ease and start vestibular exercises or rehabilitation. Refer for recurrent episodes, hearing loss or an unclear diagnosis.

Sources

Checked October 15, 2026.

Medroxyprogesterone injection (Depo-Provera CI, Depo-SubQ Provera 104)Contraception

What to say

This birth control shot is given every three months, either 150 milligrams into a muscle or 104 milligrams under the skin. Some people learn to give the under-the-skin shot at home, an off-label option the CDC supports. Get your next shot in 13 weeks; it still works if you’re up to two weeks late. If we start more than seven days after your period began, use condoms or avoid sex for seven days.

Irregular bleeding is common, and many people stop having periods, which is safe. Some gain weight. Bone density drops during use and mostly recovers after stopping. After your last shot, it often takes about 10 months, sometimes longer, to get pregnant. It doesn’t prevent sexually transmitted infections. Call us for heavy bleeding, depression, or headaches or vision changes that don’t go away. Go to the emergency department for severe belly pain or a painful, swollen leg. Chest pain, trouble breathing or stroke signs mean call 911.

Clinical reference

Dose options

Intramuscular (Depo-Provera CI)

150 mg deep IM (gluteal or deltoid) every 13 weeks

CDC SPR: reinject up to 15 weeks without backup; the label asks to exclude pregnancy beyond 13 weeks. The boxed warning discourages use beyond 2 years unless other methods are inadequate; US MEC rates DMPA category 1 at ages 18–45 and notes BMD largely recovers after stopping.

Subcutaneous (depo-subQ provera 104)

104 mg SC (anterior thigh or abdomen) every 12–14 weeks

Label: health care professional administration only. CDC SPR: offer self-administration (off-label) as an additional option. No weight-based adjustment.

Starting or late reinjection

Start any time pregnancy is reasonably excluded; backup for 7 days if more than 7 days since bleeding began. More than 15 weeks since the last dose: same approach

The label limits the first injection to the first 5 days of menses; CDC permits quick start. When late, consider emergency contraception other than ulipristal.

Before prescribing

Reasonably exclude pregnancy. US MEC: current breast cancer is category 4; BP ≥160/100, vascular disease, multiple cardiovascular risk factors, unexplained bleeding, decompensated cirrhosis and liver tumors are category 3. The label contraindicates past thromboembolism; MEC rates prior DVT or PE 2–3 by recurrence risk.

Side effects and return precautions

Bleeding changes, weight gain, mood change, injection-site reactions. BMD loss (boxed warning); meningioma with long-term use; thrombosis, ectopic pregnancy, anaphylaxis, jaundice; rare seizures.

Follow-up

Book the next injection at 13 weeks (window to 15). Review bleeding, weight, mood and satisfaction. Evaluate BMD if long-term use is planned, per the label. Stop for meningioma, jaundice or thrombosis.

Sources

Checked October 15, 2026.

MelatoninSleep timing and jet lag

What to say

Your body makes melatonin in the evening to signal nighttime. As a supplement, it’s best for shifting when you sleep rather than as a sleeping pill. For jet lag after flying east, take 0.5 to 1 milligram about 90 minutes before bedtime at your destination for the first few nights, and get outdoor daylight there. If your sleep runs late, we may suggest a low dose at [time] each evening. Guidelines don’t recommend it for long-term insomnia.

Supplement doses aren’t tightly controlled; some gummies contain up to 3.5 times the labeled amount. Avoid doses above 5 milligrams. Headache, dizziness, nausea and next-day sleepiness can happen, so don’t drive if you feel drowsy. Check with us first if you take a blood thinner, have epilepsy, or are pregnant or breastfeeding. Keep it out of children’s reach, especially gummies, which look like candy. If a child swallows some, call Poison Control at 1-800-222-1222.

Clinical reference

Dose options

Jet lag, eastward travel

0.5–1 mg about 90 minutes before local bedtime on arrival nights; avoid >5 mg

CDC Yellow Book 2026. Timing and duration depend on time zones crossed, and poorly timed doses can worsen misalignment. Westward trips need different timing.

Delayed sleep–wake phase disorder

Low dose timed in the early evening, several hours before habitual sleep onset

AASM 2015: weak recommendation for strategically timed melatonin. Write the clock time on the plan.

Chronic insomnia; dementia

Not recommended

AASM 2017 suggests against melatonin for chronic insomnia; AASM 2015 recommends against it in dementia. Use CBT-I first.

  • Dietary supplement, not FDA-approved; content varies widely (in a 2023 study of gummies, 74–347% of the labeled amount, and one had none).

Before prescribing

Distinguish circadian timing problems (jet lag, delayed sleep phase) from chronic insomnia. Review anticoagulants, epilepsy, sedatives, pregnancy or breastfeeding, dementia and older age (longer action, daytime drowsiness).

Side effects and return precautions

Headache, dizziness, nausea and daytime sleepiness. Pediatric melatonin exposures reported to poison centers rose sharply from 2012 to 2021; counsel safe storage.

Follow-up

Jet lag: use for the first few nights only. Delayed sleep phase: review sleep timing after a few weeks and stop if there’s no shift. Don’t escalate doses for insomnia.

Sources

Checked October 15, 2026.

Meloxicam (Mobic)Osteoarthritis pain

What to say

For your osteoarthritis pain, start meloxicam 7.5 milligrams once a day for [planned duration]. Take it with or without food. Food may help stomach upset. The goal is easier movement with the lowest dose that helps. Don’t increase it yourself or combine it with ibuprofen, naproxen or another anti-inflammatory pain medicine.

Indigestion, nausea or diarrhea can happen. Stop and call the same day for persistent stomach pain, much less urine or new swelling. Stop and go to the emergency department for black stools or vomiting blood. Chest pain, severe breathlessness, face drooping or speech trouble means call 911. Tell us before taking it if you could be pregnant or use aspirin or a blood thinner. We’ll review pain, activity and side effects on [date] and decide whether it should stop or continue.

Clinical reference

Dose options

Osteoarthritis symptom relief

7.5 mg orally once daily

Use conventional tablets and the lowest effective dose for the shortest necessary duration.

If additional benefit is needed

May increase to 15 mg once daily

Maximum 15 mg/day; do not substitute other meloxicam formulations milligram-for-milligram.

Renal considerations

Severe renal impairment: not recommended; hemodialysis maximum 7.5 mg/day

Assess volume status and renal risk even when a fixed dose reduction is not required.

Before prescribing

Review ulcers/bleeding, renal/CV disease, BP, volume depletion, other NSAIDs and anticoagulants. Avoid at ≥30 weeks pregnancy; use between 20–30 weeks only if necessary with appropriate monitoring.

Side effects and return precautions

GI symptoms, edema and hypertension; bleeding, renal injury, serious rash and cardiovascular events can occur without a long exposure.

Follow-up

Choose a review date and functional goal before prescribing. Longer use may require renal, BP and blood-count monitoring and gastroprotection assessment.

Sources

Checked September 23, 2026.

Meloxicam (Mobic)Rheumatoid arthritis symptom relief

What to say

For pain and stiffness from rheumatoid arthritis, take meloxicam 7.5 milligrams once daily for [planned duration]. It may ease symptoms, but it doesn’t prevent joint damage or replace your disease-modifying treatment. We’ll use the lowest dose that helps and keep reviewing whether you need it.

Don’t add ibuprofen, naproxen or another anti-inflammatory pain medicine. Check with us about aspirin or blood thinners. Stop and seek urgent care for black stools or vomiting blood. Chest pressure or severe breathlessness means call 911. Contact us for much less urine, swelling, a new rash or significant stomach pain.

Clinical reference

Dose options

Adult rheumatoid arthritis symptom relief

7.5 mg orally once daily; may increase to 15 mg once daily if needed

Conventional tablet maximum 15 mg/day; shortest necessary duration. This is adjunctive symptom treatment, not a DMARD.

Renal considerations

Severe renal impairment: not recommended; hemodialysis maximum 7.5 mg/day

Assess volume status and renal risk even when a fixed dose reduction is not required.

Before prescribing

Review ulcers/bleeding, renal/CV disease, BP, volume depletion, other NSAIDs and anticoagulants. Avoid at ≥30 weeks pregnancy; use between 20–30 weeks only if necessary with appropriate monitoring. Confirm the rheumatoid arthritis disease-control plan and review pregnancy; NSAID risks increase from about 20 weeks and use should be avoided around 30 weeks and later.

Side effects and return precautions

GI symptoms, edema and hypertension; bleeding, renal injury, serious rash and cardiovascular events can occur without a long exposure.

Follow-up

Review pain/function, BP and adverse effects within a few weeks; monitor renal function/CBC when risk or duration warrants. Persistent inflammatory symptoms need disease-treatment review, not indefinite NSAID escalation.

Sources

Checked September 23, 2026.

Metformin ER (Glucophage XR)High-risk prediabetes, off-label

What to say

We’re trying metformin extended release to lower the chance of progressing to type 2 diabetes. This is an off-label use, and we’ve discussed why it fits your situation. Start 500 milligrams with the evening meal and swallow the tablet whole. We’ll increase gradually if tolerated, alongside the food and activity plan.

Loose stools, nausea or gas are common early. Don’t increase while these are troublesome. Temporarily stop it and call for advice if vomiting or diarrhea prevents normal drinking. Tell the team before contrast scans or surgery. We’ll monitor kidney function and vitamin B12 over time. It helps most for people at higher risk, not everyone with a slightly high blood sugar.

Clinical reference

Dose options

ER start, for tolerability

500 mg with the evening meal; increase by 500 mg every 1–2 weeks if tolerated and needed, up to 2,000 mg/day for this ER product

Off-label indication. The Diabetes Prevention Program trial used immediate-release 850 mg twice daily; this ER plan is an alternative, not the trial regimen.

Renal limits

Do not initiate at eGFR 30–45; contraindicated below 30 mL/min/1.73 m²

Reassess continuation if eGFR falls below 45; stop below 30.

Before prescribing

Confirm prediabetes and high progression risk, particularly age 25–59, BMI ≥35, higher fasting glucose/A1c or prior gestational diabetes. Check eGFR, hepatic disease, alcohol, acute illness and contrast/procedure plans. Review pregnancy and other glucose-lowering drugs. Older or at-risk patients need closer renal review.

Side effects and return precautions

GI upset is common. Suspected lactic acidosis (severe weakness with respiratory distress, unusual somnolence or severe abdominal symptoms) requires stopping and emergency care. Supply a sick-day plan.

Follow-up

Review tolerance in 2–4 weeks, metabolic response in about three months, renal function at least annually and B12 periodically, sooner with anemia or neuropathy. Reassess ongoing indication and the sick-day plan.

Sources

Checked September 23, 2026.

Metformin ER (Glucophage XR)PCOS metabolic features, off-label

What to say

We’re trying metformin extended release to address insulin resistance and metabolic risks associated with PCOS. This is an off-label use, and we’ve discussed why it fits your situation. Start 500 milligrams with the evening meal and swallow the tablet whole. We’ll increase gradually if tolerated, alongside the food and activity plan.

Loose stools, nausea or gas are common early. Don’t increase while these are troublesome. Temporarily stop it and call for advice if vomiting or diarrhea prevents normal drinking. Tell the team before contrast scans or surgery. We’ll monitor kidney function and vitamin B12 over time. It can change ovulation, so discuss pregnancy intentions and contraception. It isn’t a substitute for a fertility-treatment or endometrial-protection plan.

Clinical reference

Dose options

ER start, for tolerability

500 mg with the evening meal; increase by 500 mg every 1–2 weeks if tolerated and needed, up to 2,000 mg/day for this ER product

Use this formulation’s maximum; the 2,500-mg ceiling of other formulations does not apply.

Renal limits

Do not initiate at eGFR 30–45; contraindicated below 30 mL/min/1.73 m²

Reassess continuation if eGFR falls below 45; stop below 30.

Before prescribing

Confirm PCOS and the metabolic treatment goal; guideline support is strongest in adults with BMI ≥25. Assess menstrual/endometrial issues and pregnancy intentions separately. Check eGFR, hepatic disease, alcohol, acute illness and contrast/procedure plans. Review pregnancy and other glucose-lowering drugs. Older or at-risk patients need closer renal review.

Side effects and return precautions

GI upset is common. Suspected lactic acidosis (severe weakness with respiratory distress, unusual somnolence or severe abdominal symptoms) requires stopping and emergency care. Supply a sick-day plan.

Follow-up

Review tolerance in 2–4 weeks, metabolic response in about three months, renal function at least annually and B12 periodically, sooner with anemia or neuropathy. Reassess ongoing indication and the sick-day plan.

Sources

Checked September 23, 2026.

Metformin ER (Glucophage XR)Type 2 diabetes

What to say

We’ll start metformin extended release at 500 milligrams with your evening meal. It helps lower blood sugar without usually causing low sugar on its own. Swallow the tablet whole.

The main early problem is loose stools, nausea or gas. Starting low and taking it with food helps. If you’re doing well after a week, we can follow the written plan to increase to 1,000 milligrams. Don’t increase while stomach symptoms are troublesome. We’ll check how you’re managing it in a few weeks and repeat the A1c, the average-blood-sugar test, in about three months. If vomiting or diarrhea prevents normal drinking, temporarily stop it and call for restart advice. Tell the team before surgery or scans using contrast dye, because you may need a plan for temporarily stopping it.

Clinical reference

Dose options

ER start

500 mg orally with the evening meal

Based on the generic ER label; other ER brands have their own instructions.

Titration / usual ceiling

Increase by 500 mg weekly as tolerated to 2,000 mg/day

The label allows a trial of 1,000 mg twice daily if 2,000 mg once daily is insufficient. The 2,500-mg limit of other ER products does not apply.

Renal limits

Do not initiate at eGFR 30–45; contraindicated below 30 mL/min/1.73 m²

Reassess continuation if eGFR falls below 45; stop below 30.

Before prescribing

Check eGFR, hepatic disease, alcohol, acute illness and contrast/procedure plans. Review pregnancy and other glucose-lowering drugs. Older or at-risk patients need closer renal review.

Side effects and return precautions

GI upset is common. Suspected lactic acidosis (severe weakness with respiratory distress, unusual somnolence or severe abdominal symptoms) requires stopping and emergency care. Supply a sick-day plan.

Follow-up

Early tolerance review; A1c about three months after change. Renal function at least annually, more often if risk. The ER label advises hematologic parameters annually and B12 every 2–3 years.

Sources

Checked September 20, 2026.

Methenamine hippurate (Hiprex)Recurrent UTI prevention

What to say

Methenamine helps keep bladder infections from coming back. It isn’t a standard antibiotic and doesn’t treat an active infection, so we start it after your current infection clears. Take 1 gram twice a day, morning and night. It works best in acidic urine, so avoid antacids, baking soda and potassium citrate unless we’ve discussed them. Don’t combine it with sulfa antibiotics such as Bactrim. If you drink less than about 1.5 liters a day, more water may also help.

Side effects are uncommon: nausea, upset stomach, rash or burning with urination. Call us for a rash, or for bladder symptoms so we can test your urine before treating. Get same-day care for fever, back or side pain, or vomiting. Tell us about kidney or liver problems or pregnancy. After menopause, vaginal estrogen can add protection. We’ll review how it’s working in 6 to 12 months.

Clinical reference

Dose options

Recurrent UTI prophylaxis, adults

Methenamine hippurate 1 g orally twice daily (morning and night)

Start after the current infection is eradicated. AUA/CUA/SUFU 2025 amendment: clinicians may offer it to women with recurrent UTI (conditional, Grade C).

Renal and hepatic limits

Contraindicated in renal insufficiency, severe hepatic insufficiency or severe dehydration

The label gives no eGFR cutoff; it advises periodic liver tests, especially with liver dysfunction.

  • Acts by hydrolysis to formaldehyde in acidic urine; restrict alkalinizing foods and medicines.

Before prescribing

Confirm culture-documented recurrent UTI and that the current infection is cleared. Contraindicated: renal insufficiency, severe hepatic insufficiency, severe dehydration, sulfonamides. Review urinary alkalinizers, pregnancy and vaginal estrogen if peri- or postmenopausal.

Side effects and return precautions

Nausea, dyspepsia, dysuria, rash; mild transaminase rises. Very high doses (8 g/day) have caused bladder irritation and hematuria. Culture breakthrough symptoms before treating.

Follow-up

Reassess UTI frequency and tolerance at 6–12 months; continue if effective. Recheck renal and hepatic function periodically.

Sources

Checked October 15, 2026.

Methimazole (Tapazole)Hyperthyroidism

What to say

Methimazole lowers the amount of thyroid hormone your gland makes. Take 10 milligrams once a day. It takes a few weeks to work, so we’ll check blood tests in 3 to 4 weeks and adjust the dose. A beta-blocker can ease a racing heart and shakiness meanwhile. For Graves’ disease, treatment usually lasts 12 to 18 months.

An itchy rash or joint aches can happen; call us, because they can often be managed. Rarely, it lowers infection-fighting white cells. If you get a fever, sore throat or mouth sores, stop it and get a blood count the same day. Stop it and call for yellow skin or eyes, dark urine or pale stools. Call promptly for a new rash with blood in your urine, shortness of breath or coughing blood. Tell us right away if you’re pregnant or planning pregnancy.

Clinical reference

Dose options

Adult start (guideline)

10–30 mg orally once daily, by severity; titrate down as free T4 and T3 fall

ETA 2018 regimen. The U.S. label lists 15 mg (mild), 30–40 mg (moderately severe) or 60 mg (severe) daily in 3 divided doses.

Maintenance and duration

Label maintenance 5–15 mg daily; Graves’ course usually 12–18 months

If TRAb is still high at 12–18 months, continue and recheck TRAb in 12 months, or consider radioiodine or surgery (ETA).

Pregnancy

Switch to propylthiouracil when planning pregnancy and in the first trimester (ETA)

First-trimester methimazole is linked to congenital malformations (e.g., aplasia cutis, choanal or esophageal atresia). Pregnancy needs a separate plan.

  • Tapazole is a historical U.S. brand name; prescribe generic methimazole.

Before prescribing

Confirm the cause (Graves’ or toxic nodule, not thyroiditis). Baseline CBC with differential and LFTs. Ask about pregnancy plans. Interactions: warfarin effect may rise; beta-blocker, digoxin and theophylline needs fall as euthyroid.

Side effects and return precautions

Rash, urticaria, arthralgia (minor rash: antihistamine and continue). Fever or pharyngitis: stop and check CBC with differential for agranulocytosis. Stop if ALT/AST >3× ULN or jaundice. ANCA vasculitis. Hypothyroidism from overtreatment.

Follow-up

Free T4 and T3 at 3–4 weeks, then periodically while titrating; TSH can lag. Routine repeat CBC/LFTs aren’t useful without symptoms. Check TRAb before stopping; definitive therapy if relapse.

Sources

Checked October 15, 2026.

Methocarbamol (Robaxin)Acute muscle spasm

What to say

Methocarbamol is a muscle relaxant for a short spell of painful muscle spasm, used with heat, gentle movement and the activity plan we discussed. Take 1,500 milligrams, which is three 500-milligram tablets, four times a day for the first 2–3 days. Then take 1,000 milligrams, two tablets, four times a day. Stop once the spasm settles; it’s meant for days, not weeks.

Drowsiness, dizziness, blurred vision and upset stomach can happen. Don’t drive until you know how it affects you, and avoid alcohol, opioids, sleep aids and other sedating medicines unless we’ve checked. Your urine may turn black, blue or green. Call us for yellow skin or eyes, or a rash. Call 911 for trouble breathing, swelling of the face or throat, a seizure, or fainting. If you could be pregnant, tell us before taking it, because we’d usually choose something else.

Clinical reference

Dose options

Adults, label regimen

1,500 mg four times daily for 48–72 hours (up to 8 g/day if severe), then about 4 g/day, e.g., 1,000 mg four times daily

Label maintenance alternatives: 750 mg every 4 hours or 1,500 mg three times daily. Adjunct to rest and physical measures.

Older adults, liver or kidney disease

No labeled dose adjustment; clearance falls about 70% in alcohol-related cirrhosis and is reduced on hemodialysis

Consider lower doses or avoid with frailty or fall risk; Beers criteria advise avoiding skeletal muscle relaxants in older adults.

Before prescribing

Confirm acute musculoskeletal spasm without red flags. Review alcohol, opioids and other CNS depressants, driving, falls, pregnancy, hepatic disease, and myasthenia gravis on pyridostigmine (methocarbamol may blunt it).

Side effects and return precautions

Drowsiness, dizziness, blurred vision, GI upset; rarely bradycardia, hypotension, syncope, jaundice, leukopenia, seizures or anaphylaxis. Urine may turn black, blue or green.

Follow-up

Review within 1–2 weeks if still needed; stop when spasm settles. Reassess persistent or worsening pain, neurologic symptoms or red flags rather than extending the course.

Sources

Checked October 15, 2026.

Methotrexate (Trexall, Otrexup)Rheumatoid arthritis

What to say

Methotrexate calms the immune system to ease joint inflammation and prevent damage. Take it once a week only, on the same day: [number] 2.5-milligram tablets together on [day]. Taking it daily by mistake can be fatal. Take the folic acid we prescribe to reduce side effects. Improvement often starts in 3–6 weeks and can take up to 12. We’ll check your blood counts, liver and kidneys regularly.

Nausea, tiredness, mouth sores and hair thinning can happen; tell us, since adjustments often help. Avoid alcohol; it raises liver risk. Check with us before new medicines, especially the antibiotic Bactrim, and before any live vaccine. It can cause miscarriage and birth defects, so use reliable birth control and talk with us well before you or a partner try to conceive. Call the same day for fever, a new cough or breathlessness, or unusual bruising or bleeding. Severe trouble breathing means call 911.

Clinical reference

Dose options

RA, oral once weekly

Label start 7.5 mg once weekly; ACR 2021 favors reaching ≥15 mg/week within 4–6 weeks as tolerated

Label: >20 mg/week raises the risk of serious toxicity. For intolerance or inadequate response, ACR suggests split oral dosing over 24 hours or weekly subcutaneous injection (e.g., Otrexup).

Supplements, organ function, pregnancy

Give folic or folinic acid; reduce or stop for renal impairment (monitor closely if CrCl <90 mL/min) or hepatic impairment

Label contraception: females during and 6 months after the last dose; males with partners who could conceive, 3 months. ACR patient guidance: stop at least 3 months before trying to conceive.

  • Write the weekday and once-weekly dosing on every prescription; usually started and adjusted with rheumatology.

Before prescribing

Pregnancy test and contraception plan. Baseline CBC, creatinine, LFTs and hepatitis screening; alcohol use. Interactions: TMP-SMX and other sulfonamides, NSAIDs, PPIs, penicillins, nitrous oxide. Update vaccines before starting; avoid live vaccines.

Side effects and return precautions

Myelosuppression, hepatotoxicity, pneumonitis, mucositis, serious infections, renal toxicity, severe skin reactions. Daily-dosing errors have caused deaths; overdose needs urgent treatment.

Follow-up

Usually rheumatology-led. Monitor CBC, creatinine and LFTs regularly, more often early and after dose increases (ACR 2021 defers to its 2008/2012 monitoring schedules). Treat to target.

Sources

Checked October 15, 2026.

Methylphenidate ER (Concerta)ADHD

What to say

I’m starting Concerta 18 milligrams each morning for ADHD. Swallow the tablet whole with water, with or without food. Don’t split, crush, or chew it. An empty tablet shell may appear in your stool, which is normal. We’ll judge benefit by specific tasks such as finishing work and keeping track of appointments, along with how you feel.

Less appetite, trouble sleeping, or a faster pulse can happen. Take it early, and don’t take an extra dose if the effect wears off. If you forget until late in the day, skip it and resume the next morning. Call 911 for chest pain, fainting, or severe shortness of breath. Call the same day for hallucinations or major mood changes. Store it locked up and never share it. We’ll check your blood pressure, pulse, weight, sleep, and benefit within two weeks before changing the dose.

Clinical reference

Dose options

Adult Concerta start

18 or 36 mg orally each morning; the wording above uses 18 mg

Labeled adults through age 65. This osmotic-release tablet must be swallowed whole; not interchangeable by instructions with all methylphenidate ER products.

Titration / maximum

Increase by 18 mg at weekly intervals if needed; maximum 72 mg/day

27 mg provides an intermediate step. Use the product’s conversion table when changing from immediate-release methylphenidate; do not improvise an ER conversion.

Older age / organ impairment

Not studied above age 65; individualize in hepatic/renal disease

No validated routine adjustment is specified. Stop/reconsider if no improvement after appropriate dose modification for a month.

Before prescribing

Confirm ADHD diagnosis/impairment; assess BP/pulse/weight, cardiac and family sudden-death history, tics, bipolar/psychosis and substance-use/diversion risk. Avoid serious cardiac disease and MAOIs within 14 days. Evaluate swallowing difficulty/GI narrowing.

Side effects and return precautions

Boxed warning: abuse, misuse and addiction. Monitor appetite/weight, insomnia, BP/pulse, mood and circulation changes. Chest pain/syncope needs urgent emergency evaluation; painful prolonged erection ≥4 hours requires emergency care.

Follow-up

Early review during titration, with symptoms and adverse effects at each step. BP/pulse before/after each dose change and at least every 6 months; adult weight every 6 months or sooner if declining. Review continued need and secure storage.

Sources

Checked September 20, 2026.

Metoprolol succinate ER (Toprol-XL)Atrial fibrillation rate control, off-label

What to say

For atrial fibrillation, metoprolol helps keep your heart from racing. Take the extended-release tablet at [prescribed dose] once daily with or just after food. We’ll use your pulse, symptoms and blood pressure to adjust it. This is an off-label use of this product supported by heart-rhythm guidance. It controls rate. It doesn’t replace the separate decision about stroke-prevention medicine.

Tiredness, dizziness or a slow pulse can occur. Use the pulse and blood-pressure limits we write down for when to call. Fainting, severe breathing difficulty or new persistent chest pain needs emergency care. Don’t stop suddenly. We’ll taper it if the plan changes.

Clinical reference

Dose options

Long-term oral rate control

Individualized once-daily dose; guideline maintenance range 50–400 mg/day

This range is not a standard starting dose. Start lower when HF, frailty, BP or conduction risk warrants it. It does not cover IV conversion or acute rapid AF.

Before prescribing

Confirm AF and clinical stability; exclude pre-excitation and assess pulse, BP, conduction disease, HF status, bronchospasm and other AV-node blockers. Address anticoagulation and rhythm-control options separately.

Side effects and return precautions

Fatigue, dizziness, bradycardia and hypotension; bronchospasm/worsening HF. May mask tachycardia with hypoglycemia; give individualized pulse/BP call thresholds.

Follow-up

Review pulse, BP, exertional symptoms and ECG as indicated after starting or changing dose. Use an individualized rate target and taper planned withdrawal.

Sources

Checked September 23, 2026.

Metoprolol succinate ER (Toprol-XL)Chronic stable angina

What to say

For stable angina, take metoprolol succinate extended release [prescribed dose] once daily with or just after food. It slows the heart to reduce chest-pain episodes and help you tolerate activity. Swallow it without crushing or chewing. It doesn’t replace your rescue plan for chest pain.

Tiredness, dizziness or a slow pulse can occur. Use the pulse and blood-pressure limits we write down for when to call. Fainting, severe breathing difficulty or new persistent chest pain needs emergency care. Don’t stop suddenly. We’ll taper it if the plan changes.

Clinical reference

Dose options

Labeled adult angina start

100 mg orally once daily; individualize the starting prescription

Increase at weekly intervals until benefit or pronounced heart-rate slowing; doses above 400 mg/day have not been studied. Frailty, bradycardia, liver disease or coexisting HF may require a different starting plan.

Before prescribing

Confirm stable angina and review resting pulse, BP, conduction disease, decompensated HF, bronchospasm and other rate-slowing drugs. Use succinate ER, not the tartrate schedule.

Side effects and return precautions

Fatigue, dizziness, bradycardia and hypotension; bronchospasm/worsening HF. May mask tachycardia with hypoglycemia; give individualized pulse/BP call thresholds.

Follow-up

Review pulse, BP, angina frequency and activity tolerance within 1–2 weeks. If stopping, taper over 1–2 weeks with monitoring.

Sources

Checked September 23, 2026.

Metoprolol succinate ER (Toprol-XL)Heart failure

What to say

We’re starting the extended-release form of metoprolol at 25 milligrams once a day as part of your stable heart-failure treatment. It slows the heart and reduces its workload. This form is taken once daily. It’s different from the short-acting tablet.

You may feel more tired or lightheaded at first. We’ll review your pulse, blood pressure, breathing and weight before increasing the dose. Call the same day for worsening swelling or breathlessness, a pulse below [personalized threshold] with dizziness, or new wheezing. Severe breathing trouble, fainting or chest pain means call 911. Don’t stop suddenly. If we need to stop it, we usually reduce it gradually. Swallow the tablet or prescribed half-tablet without crushing or chewing.

Clinical reference

Dose options

Stable symptomatic HFrEF

12.5–25 mg orally once daily; double about every 2 weeks as tolerated, up to 200 mg daily

Start only when clinically stable. 12.5 mg is used in more severe HF; worsening congestion may require treatment before titration.

Formulation / organ function

Succinate ER, once daily; not the same schedule as tartrate immediate release

No routine renal adjustment; lower initial dose and gradual increase in hepatic impairment. Scored tablets may be split if product permits.

Before prescribing

Check pulse, BP, conduction disease, volume status/decompensation, bronchospasm and other rate-slowing medicines. Severe bradycardia, advanced block without a pacemaker, cardiogenic shock or decompensated HF can contraindicate starting.

Side effects and return precautions

Fatigue, dizziness, bradycardia and hypotension; bronchospasm/worsening HF. May mask tachycardia with hypoglycemia; give individualized pulse/BP call thresholds.

Follow-up

HF review about every two weeks during titration; check symptoms, pulse/BP and fluid status. If stopping chronically used therapy, generally taper over 1–2 weeks with monitoring.

Sources

Checked September 22, 2026.

Metoprolol succinate ER (Toprol-XL)Hypertension

What to say

For your blood pressure, take extended-release metoprolol 25 milligrams once daily. Take it consistently with or just after a meal. This is the once-daily succinate tablet. Keep a record of your home blood pressure and pulse so we can review the effect before adjusting the dose.

You may feel more tired or lightheaded at first. We’ll review your pulse, blood pressure, breathing and weight before increasing the dose. Call the same day for worsening swelling or breathlessness, a pulse below [personalized threshold] with dizziness, or new wheezing. Severe breathing trouble, fainting or chest pain means call 911. Don’t stop suddenly. If we need to stop it, we usually reduce it gradually. Swallow the tablet or prescribed half-tablet without crushing or chewing.

Clinical reference

Dose options

Hypertension

25–100 mg once daily initially; titrate weekly or longer

Doses above 400 mg/day have not been studied for hypertension; this is distinct from the HF target.

Formulation / organ function

Succinate ER, once daily; not the same schedule as tartrate immediate release

No routine renal adjustment; lower initial dose and gradual increase in hepatic impairment. Scored tablets may be split if product permits.

Before prescribing

Check pulse, BP, conduction disease, volume status/decompensation, bronchospasm and other rate-slowing medicines. Severe bradycardia, advanced block without a pacemaker, cardiogenic shock or decompensated HF can contraindicate starting.

Side effects and return precautions

Fatigue, dizziness, bradycardia and hypotension; bronchospasm/worsening HF. May mask tachycardia with hypoglycemia; give individualized pulse/BP call thresholds.

Follow-up

Review BP, pulse and orthostatic symptoms after initiation and before titration at weekly or longer intervals. Use individualized pulse/BP call thresholds. Gradually taper planned withdrawal over 1–2 weeks.

Sources

Checked September 22, 2026.

Metoprolol tartrate (Lopressor)Hypertension and angina; heart-rate control off-label

What to say

Metoprolol tartrate is a short-acting beta-blocker that slows your heart and lowers blood pressure. We use it for high blood pressure and angina, and off-label to slow a fast heart rhythm such as atrial fibrillation. Take [dose], usually 25 to 100 milligrams, twice a day, about 12 hours apart, with or right after a meal. It isn’t the same as once-daily metoprolol succinate, so don’t swap one for the other.

At first you may feel tired or dizzy, or notice cold hands; get up slowly. Don’t stop it suddenly, which can trigger chest pain or a heart attack; we’ll taper it over 1–2 weeks if needed. Call us for a pulse under 50 with dizziness, new wheezing, or swelling with shortness of breath. Call 911 for fainting or chest pain. Some antidepressants, like fluoxetine and paroxetine, raise its level; check with us before new medicines.

Clinical reference

Dose options

Hypertension

Commonly 25–100 mg twice daily with or right after meals

Label: usual initial 100 mg/day in single or divided doses, effective range 100–450 mg/day, titrated at weekly or longer intervals. Twice-daily dosing maintains effect better at lower doses.

Angina; AF rate control (off-label)

Angina: 100 mg/day in 2 divided doses, titrated weekly (100–400 mg/day). AF: 25–200 mg twice daily

AF range from the 2023 ACC/AHA/ACCP/HRS guideline. Taper over 1–2 weeks when stopping.

Not for HFrEF

Use metoprolol succinate ER (or carvedilol or bisoprolol)

Tartrate and succinate schedules aren’t interchangeable; converting needs a new prescription.

  • Brand Lopressor tablets (2026 label) list only post-MI use; generic metoprolol tartrate labels list hypertension, angina and MI. Oral AF rate control is off-label but guideline-supported.

Before prescribing

Contraindicated: severe bradycardia, second- or third-degree block, sick sinus syndrome without pacemaker, cardiogenic shock, decompensated HF, SBP <100. Caution: asthma/COPD, diabetes, PAD, pheochromocytoma. Review CYP2D6 inhibitors, verapamil/diltiazem, digoxin, clonidine.

Side effects and return precautions

Bradycardia, fatigue, dizziness, cold extremities, bronchospasm, HF worsening during titration, masked hypoglycemia. Strong CYP2D6 inhibitors double levels. Abrupt withdrawal: angina, MI.

Follow-up

Recheck BP and resting heart rate 1–2 weeks after starting or changing dose; in AF, assess rate at rest and with activity. Taper over 1–2 weeks when stopping.

Sources

Checked October 15, 2026.

Metronidazole (Flagyl)Bacterial vaginosis

What to say

For bacterial vaginosis, the change in vaginal bacteria causing your discharge or odor, take metronidazole 500 milligrams twice a day for seven days. This is the oral tablet. Nausea or a metallic taste can happen. Taking it with food may help.

For this course, avoid alcohol during treatment and for three days after the last dose, following the product warning. Check liquid medicines with the pharmacist because some contain alcohol or propylene glycol. Avoid douching, and avoid sex or use condoms during treatment. Stop and call the same day for a new rash, numbness or tingling. A blistering rash or mouth sores means go to the emergency department. Trouble breathing means call 911. Contact us if symptoms persist after treatment or return. Call the same day for fever or pelvic pain, because that may need a different assessment.

Clinical reference

Dose options

Symptomatic bacterial vaginosis

Immediate-release tablets: 500 mg orally twice daily for 7 days

CDC-recommended regimen. Vaginal gel and extended-release oral products use different schedules.

Alcohol counseling discrepancy

U.S. tablet labeling: avoid alcohol/propylene glycol during treatment and ≥3 days afterward

CDC BV guidance finds no convincing disulfiram-like interaction and says abstinence is unnecessary. The wording above follows the label; explain the difference if asked.

Severe hepatic impairment

Reduce dose by 50% in Child-Pugh C per tablet labeling

Other infections, dialysis and complicated hepatic/renal contexts need indication-specific planning.

Before prescribing

Confirm BV and review pregnancy, STI/pelvic symptoms, liver disease, neuropathy, warfarin/lithium interactions and recent disulfiram. Oral BV regimen is guideline-based; do not equate BV with every cause of discharge.

Side effects and return precautions

GI upset/metallic taste; new rash or neurologic symptoms warrant stopping and prompt review. Severe cutaneous or CNS reactions need emergency care.

Follow-up

No routine visit is required if symptoms resolve. Persistent/recurrent symptoms need reassessment and an individualized recurrence plan; do not imply the first course prevents all recurrence.

Sources

Checked September 20, 2026.

Metronidazole (Flagyl)Trichomoniasis in men

What to say

Take metronidazole two grams (2,000 milligrams) by mouth once to treat trichomoniasis. Check the tablet strength so you take the full prescribed dose. Taking it with food may help nausea. A metallic taste can happen. Avoid alcohol during treatment and for three days afterward, following the product warning.

Your current sexual partners need treatment too, even without symptoms. Avoid sex until everyone has completed treatment and symptoms have resolved. Call for persistent symptoms, fever or pelvic/testicular pain. Stop and call for new numbness or tingling. A blistering rash, severe confusion or trouble breathing needs emergency assessment.

Clinical reference

Dose options

CDC regimen for men

2 g orally once

Oral tablets; vaginal metronidazole gel is not an adequate treatment for trichomoniasis.

  • Alcohol advice follows U.S. product labeling. CDC notes the evidence for a disulfiram-like interaction is unconvincing; explain that difference if asked.

Before prescribing

Confirm infection, nitroimidazole allergy, pregnancy/breastfeeding, liver disease and interacting drugs such as warfarin, lithium or disulfiram. Severe hepatic impairment requires dose adjustment. Arrange other STI testing and current-partner treatment.

Side effects and return precautions

GI symptoms and metallic taste; neuropathy and serious skin/neurologic reactions are uncommon. Persistent infection requires assessment of adherence, reinfection and resistance.

Follow-up

Evidence is insufficient for routine retesting in men; reassess persistent symptoms or re-exposure. If NAAT is used for persistent/recurrent infection, wait at least 3 weeks after therapy.

Sources

Checked September 23, 2026.

Metronidazole (Flagyl)Trichomoniasis in women

What to say

Take metronidazole 500 milligrams twice a day for seven days to treat trichomoniasis. Taking it with food may help nausea. A metallic taste can happen. Avoid alcohol during treatment and for three days afterward, following the product warning.

Your current sexual partners need treatment too, even without symptoms. Avoid sex until everyone has completed treatment and symptoms have resolved. Call for persistent symptoms, fever or pelvic/testicular pain. Stop and call for new numbness or tingling. A blistering rash, severe confusion or trouble breathing needs emergency assessment.

Clinical reference

Dose options

CDC regimen for women

500 mg orally twice daily for 7 days

Oral tablets; vaginal metronidazole gel is not an adequate treatment for trichomoniasis.

  • Alcohol advice follows U.S. product labeling. CDC notes the evidence for a disulfiram-like interaction is unconvincing; explain that difference if asked.

Before prescribing

Confirm infection, nitroimidazole allergy, pregnancy/breastfeeding, liver disease and interacting drugs such as warfarin, lithium or disulfiram. Severe hepatic impairment requires dose adjustment. Arrange other STI testing and current-partner treatment.

Side effects and return precautions

GI symptoms and metallic taste; neuropathy and serious skin/neurologic reactions are uncommon. Persistent infection requires assessment of adherence, reinfection and resistance.

Follow-up

Retest sexually active women at about 3 months, regardless of reported partner treatment. If NAAT is used for persistent/recurrent infection, wait at least 3 weeks after therapy.

Sources

Checked September 23, 2026.

Metronidazole 0.75% vaginal gel (Vandazole)Bacterial vaginosis

What to say

For bacterial vaginosis, the change in vaginal bacteria that causes discharge or odor, use 1 full applicator of metronidazole 0.75% gel, about 5 grams, in your vagina at bedtime for 5 nights in a row. Avoid sex or use condoms until you finish. Avoid alcohol during treatment and for 3 days afterward, as the label advises.

About 1 in 10 people get a yeast infection during or after treatment. Call if you develop itching or thick white discharge. Vaginal irritation, cramps or nausea can also happen. Tell us if you take warfarin or lithium, or took disulfiram in the past 2 weeks. Stop it and call the same day for a rash, numbness or tingling. Trouble breathing or swelling of your lips or tongue means call 911. Contact us if symptoms don’t clear or keep coming back. Fever or pelvic pain needs a same-day visit.

Clinical reference

Dose options

Symptomatic BV, nonpregnant adult

0.75% gel, 1 applicator (5 g, about 37.5 mg) intravaginally once daily at bedtime for 5 days

CDC-recommended regimen; matches the Vandazole label. Some generic labels also allow twice daily.

Alternative

Clindamycin 2% cream, 1 applicator (5 g) intravaginally at bedtime for 7 days

Oil based; may weaken latex condoms and diaphragms for 5 days after use (CDC).

Alcohol and recurrence

Vandazole label: no alcohol during and for 3 days after; CDC: abstaining is unnecessary

Script follows the label. Recurrent BV: CDC describes 0.75% gel twice weekly for >3 months after a treatment course; benefit fades after stopping.

Before prescribing

Confirm BV and consider trichomoniasis, candidiasis, cervicitis or PID. Review pregnancy, metronidazole or paraben allergy, disulfiram within 2 weeks, warfarin and lithium.

Side effects and return precautions

Vulvovaginal candidiasis (about 10%), vaginal irritation, cramps, nausea. Stop for rash or neurologic symptoms. Fever or pelvic pain suggests PID or another diagnosis.

Follow-up

No test-of-cure if symptoms resolve. Reassess persistent or recurrent symptoms and discuss suppressive therapy for repeated recurrences.

Sources

Checked October 15, 2026.

Metronidazole 1% gel (MetroGel)Rosacea

What to say

Metronidazole gel treats the bumps and pimples of rosacea. After washing gently and patting dry, apply a thin layer of the 1% gel once a day over the whole affected area, not just individual spots. You can put on sunscreen or makeup afterward. You may notice fewer bumps within a few weeks; the full effect can take 2–3 months. Keep using it to stop the bumps coming back. It doesn’t treat ongoing redness or flushing, which need other treatments.

Mild burning, stinging, dryness or itching can happen. Keep it away from your eyes. Stop it and call us for a spreading rash, or numbness or tingling in your hands or feet. Daily sunscreen, a gentle cleanser and avoiding your own triggers, such as sun, heat, stress, alcohol and spicy food, can help. Tell us about gritty, red or irritated eyes, which can be part of rosacea. Eye pain, light sensitivity or blurred vision needs same-day eye care.

Clinical reference

Dose options

Papulopustular rosacea, 1% gel

Thin film once daily to affected areas after cleansing

MetroGel is the 1% reference product; AB-rated generics exist. The pivotal trial assessed response at 10 weeks. Cosmetics may be applied afterward.

0.75% gel, cream or lotion

Thin film twice daily, morning and evening, after washing

Strengths have different schedules; match the instructions to the dispensed product.

Before prescribing

Confirm papulopustular rosacea (no comedones; consider acne, perioral or seborrheic dermatitis, steroid-induced rosacea). Assess eye symptoms and erythema or flushing needing other treatment. Review metronidazole allergy, neuropathy, blood dyscrasia, warfarin.

Side effects and return precautions

Burning, dryness, irritant or allergic contact dermatitis and eye tearing. Peripheral neuropathy has been reported; reevaluate if it occurs. Eye pain, photophobia or reduced vision needs urgent eye assessment.

Follow-up

Assess inflammatory lesions at about 8–12 weeks and continue if helpful. If response is inadequate, consider ivermectin 1% cream, azelaic acid or oral subantimicrobial doxycycline; treat persistent erythema separately.

Sources

Checked October 15, 2026.

Miconazole vaginal (Monistat)Vaginal yeast infection

What to say

For this vaginal yeast infection, use over-the-counter miconazole, such as Monistat. Insert 1 dose into the vagina, usually at bedtime, for 1, 3 or 7 nights, depending on the product. For itchy skin outside the vagina, apply the external cream up to twice a day for up to 7 days. Finish the course even if you feel better sooner.

Burning, itching or irritation can briefly get worse. These products can weaken condoms and diaphragms, so they may not prevent pregnancy or infections. Avoid sex, tampons and douches during treatment. Check with us first if you take warfarin, because bleeding or bruising can occur, or if you could be pregnant. Call if you’re not better in 3 days, still have symptoms after 7, or symptoms return within 2 months. Fever, chills, belly or back pain, vomiting, or foul-smelling discharge needs a same-day call.

Clinical reference

Dose options

OTC intravaginal miconazole (CDC)

2% cream 5 g daily ×7 days; 4% cream 5 g ×3 days; 100 mg suppository ×7 days; 200 mg ×3 days; 1,200 mg ×1 day

Plus 2% external cream twice daily up to 7 days for vulvar itch. Oil based; may weaken latex condoms and diaphragms.

Oral alternative

Fluconazole 150 mg orally once

CDC-recommended for uncomplicated VVC; check interactions and pregnancy.

Before prescribing

Confirm uncomplicated VVC; a first episode or atypical symptoms need exam and testing. Ask about pregnancy, diabetes, immunosuppression, ≥3 episodes a year, STI exposure and warfarin.

Side effects and return precautions

Local burning or irritation. Fever, abdominal or pelvic pain, foul discharge, or no response in 3 days suggests another diagnosis. Recurrence within 2 months needs testing.

Follow-up

No routine follow-up if resolved. Persistent symptoms after OTC treatment or recurrence within 2 months needs exam and culture; ≥3 episodes a year needs a recurrent-VVC plan.

Sources

Checked October 15, 2026.

Micronized progesterone capsules (Prometrium)Endometrial protection with systemic estrogen

What to say

Because you’re using estrogen treatment for hot flashes and still have a uterus, we’re adding progesterone to protect the uterine lining. Take 200 milligrams by mouth at bedtime for the first twelve days of each 28-day treatment cycle, following the calendar we’ve written down. Continue your estrogen on its prescribed schedule. This isn’t birth control.

Progesterone can make you sleepy or dizzy, so take it at bedtime and avoid driving afterward until you know its effect. These capsules contain peanut oil. Don’t take them if you have a peanut allergy. Period-like bleeding can occur after the progesterone days. Call about unexpected, persistent or heavy bleeding. Call 911 for heavy bleeding with faintness. We’ll review your symptoms and bleeding in eight to twelve weeks. Contact us if you miss several doses so we can restore adequate lining protection.

Clinical reference

Dose options

Cyclic endometrial protection

200 mg orally at bedtime for 12 consecutive days of each 28-day cycle

U.S. labeled regimen studied with daily conjugated estrogen; guidelines use cyclic micronized progesterone alongside systemic estrogen, with dose adequacy reviewed.

Continuous combined alternative

100 mg orally at bedtime every day

Guideline-supported regimen with standard/low-dose estrogen; not the labeled U.S. cyclic capsule regimen. Higher estrogen doses may need greater progestogen protection.

Formulation

Use the prescribed oral micronized capsules

Do not substitute compounded progesterone cream or a contraceptive pill without confirming adequate endometrial protection.

Before prescribing

Confirm uterus status, systemic estrogen dose, bleeding history, pregnancy possibility, hormone-related contraindications and peanut allergy (the capsules contain peanut oil). Investigate unexplained bleeding before starting. Agree on a clearly dated cyclic or continuous schedule.

Side effects and return precautions

Somnolence, dizziness, breast tenderness and bleeding changes are common. Assess heavy/persistent bleeding and symptoms suggesting thrombosis. Avoid assuming that any progesterone route or dose protects the endometrium equally.

Follow-up

Review at 8–12 weeks, including adherence, sedation and bleeding. Reassess protection whenever estrogen dose changes. Persistent/new bleeding requires evaluation rather than repeated dose changes alone.

Sources

Checked September 20, 2026.

Minoxidil 5% foam (Rogaine)Female-pattern hair loss

What to say

For your female-pattern hair thinning, apply half a capful of the women’s 5% minoxidil foam to the affected scalp once a day. Part the hair so it reaches dry scalp, rather than coating the hair. Wash your hands afterward, let it dry, and avoid transfer to your face, other people or pets. Keep it away from flames until dry.

Some early shedding or scalp irritation can happen. Improvement may take three to six months, and continued treatment is needed to keep the benefit. More frequent application won’t speed this up. Stop and contact us the same day if you develop swelling, a racing heartbeat or dizziness. Call 911 for chest pain, fainting or severe breathlessness. Don’t use it during pregnancy or breastfeeding without discussing an alternative. We’ll compare photographs in about three months.

Clinical reference

Dose options

Women: 5% foam

Half a capful to the affected scalp once daily

Allow up to six months to assess response; follow the women’s product instructions.

Application

Apply to dry, intact scalp; wash hands and let dry

Do not use on inflamed/broken skin or increase the amount. Oral minoxidil has a different risk profile.

Before prescribing

Confirm patterned thinning rather than sudden, patchy, inflammatory or unexplained loss. Review pregnancy/breastfeeding, heart disease and other scalp products. Select a sex- and formulation-specific package; foam and solution directions differ.

Side effects and return precautions

Irritation, temporary shedding and unwanted facial hair may occur. Stop for systemic cardiovascular symptoms. Keep out of children’s and pets’ reach and prevent contact with treated skin; wet product is flammable.

Follow-up

Baseline photographs; review application and tolerance at 1–3 months and response at 3–6 months. Persistent scalp irritation or unexpectedly rapid loss requires reassessment.

Sources

Checked September 23, 2026.

Minoxidil 5% foam (Rogaine)Male-pattern hair loss

What to say

For gradual thinning at the crown of your scalp, apply half a capful of men’s 5% minoxidil foam twice daily. Put it on the dry scalp, not just the hair. Wash your hands afterward and let it dry. Keep it away from flames and prevent transfer to children or pets.

Some shedding or scalp irritation can occur early. More product won’t speed regrowth. It takes months to assess benefit, and continued use is needed to maintain it. Stop and contact us for swelling, dizziness or a racing heartbeat. Chest pain, fainting or severe breathlessness needs emergency care. If there’s no regrowth after four months, stop and contact us for reassessment.

Clinical reference

Dose options

Men’s 5% foam

Half a capful to affected scalp twice daily

Label concerns gradual vertex thinning, not sudden or patchy loss. Do not use the once-daily women’s foam schedule interchangeably.

Application

Apply to dry, intact scalp; wash hands and let dry

Do not use on inflamed/broken skin or increase the amount. Oral minoxidil has a different risk profile.

Before prescribing

Confirm gradual male-pattern vertex thinning rather than sudden, patchy, inflammatory or unexplained loss. Review age, heart disease, intact scalp and other scalp products. Select the men’s 5% foam package; foam and solution directions differ.

Side effects and return precautions

Irritation, temporary shedding and unwanted facial hair may occur. Stop for systemic cardiovascular symptoms. Keep out of children’s and pets’ reach and prevent contact with treated skin; wet product is flammable.

Follow-up

Review technique and tolerance at 1–3 months, and response by four months. Reassess unexplained or rapid loss; continued use is required to maintain regrowth.

Sources

Checked September 23, 2026.

Minoxidil oral (Loniten)Hair loss, off-label

What to say

We’ve discussed using oral minoxidil for your hair loss because topical treatment hasn’t suited you. This use is off label. We’re choosing a conservative start of 0.625 milligrams every other day, using the exact tablet and splitting instructions confirmed by the pharmacist. Don’t change the dose on your own. We’ll check your blood pressure and pulse in one to two weeks before considering any increase.

Hair growth takes months. Extra body or facial hair and early shedding can happen. This medicine can also lower blood pressure or cause fluid retention and a fast heartbeat. Stop and call the same day for new ankle swelling, rapid weight gain or a racing or irregular heartbeat. Call 911 for chest pain, fainting or severe breathlessness. Avoid it while trying to conceive, pregnant or breastfeeding. We’ll assess the hair response after about six months.

Clinical reference

Dose options

Conservative start

0.625 mg orally every other day

From one published NHS hair-service protocol; not a standard U.S. starting dose. Confirm accurate quartering of the 2.5-mg tablet or use a pharmacist-prepared dose.

Individualized hair-service dosing

The cited protocol uses 0.625–2.5 mg doses with clinician-led adjustment

Frequency and increases require a written plan, BP/pulse review and tolerance assessment. There is no FDA-approved alopecia dose or maximum.

Separate labeled indication

Oral minoxidil’s U.S. label is for severe refractory hypertension

Its hypertension doses and companion-drug requirements do not apply to a hair-loss prescription.

Before prescribing

Confirm the alopecia diagnosis and informed off-label choice. Check BP/pulse, edema, cardiac/pericardial and kidney history, pregnancy/fertility plans and antihypertensives. Cardiac or renal risk may warrant specialist input; order testing based on that assessment.

Side effects and return precautions

Hypertrichosis, postural dizziness, tachycardia and fluid retention are relevant even at low doses. The oral label warns of pericardial effusion/tamponade and angina; low-dose use does not eliminate these risks.

Follow-up

Check baseline and home BP/pulse, make contact at 1–2 weeks and after increases, then review tolerance and photographs at 3–6 months. Do not increase while symptomatic or without a monitoring plan.

Sources

Checked September 20, 2026.

Mirabegron (Myrbetriq)Overactive bladder

What to say

For bladder urgency, frequent urination and leakage, start mirabegron extended release 25 milligrams once a day, with or without food. Swallow it whole with water. Don’t chew, split or crush it. If you miss a dose, take it unless more than 12 hours have passed. It usually causes less dry mouth and constipation than older bladder pills. Keep up your bladder training. Benefit builds over weeks, so we’ll review your bladder diary and blood pressure in 4–8 weeks and decide whether to increase to 50 milligrams.

Headache, cold symptoms or a urine infection can happen. It can raise blood pressure, so tell us if your home readings climb. If you can’t pass urine, go to the emergency department. Swelling of the face, lips, tongue or throat, or trouble breathing, means stop it and call 911. It raises levels of some medicines, including metoprolol, some antidepressants, heart-rhythm medicines and digoxin, so check with us before starting new ones.

Clinical reference

Dose options

Adult OAB, extended-release tablet

25 mg orally once daily; may increase to 50 mg after 4–8 weeks

Maximum 50 mg. Swallow whole, with or without food. Missed dose: take within 12 hours, otherwise skip. Myrbetriq granules (pediatric) are not mg-for-mg interchangeable.

Renal or hepatic impairment

eGFR 15–29 or Child-Pugh B: maximum 25 mg daily; eGFR <15, dialysis or Child-Pugh C: not recommended

No adjustment for eGFR 30–89 or Child-Pugh A.

  • AUA/SUFU 2024 offers beta-3 agonists or antimuscarinics and asks clinicians to discuss dementia risk with antimuscarinics. Vibegron (Gemtesa) 75 mg daily is the other beta-3 agonist, without mirabegron’s BP warning or CYP2D6 inhibition.

Before prescribing

Exclude UTI, hematuria and retention (check PVR with emptying symptoms or BPH). Check BP; not recommended with severe uncontrolled hypertension (≥180/110). Review eGFR, liver disease, antimuscarinic co-use, digoxin and CYP2D6 substrates (metoprolol, TCAs, flecainide, propafenone).

Side effects and return precautions

Hypertension, headache, nasopharyngitis, UTI. Urinary retention with outlet obstruction or antimuscarinics. Angioedema: stop and protect the airway. Postmarketing atrial fibrillation. Raised CYP2D6-substrate and digoxin levels.

Follow-up

Review diary, BP and side effects within 4–8 weeks (AUA/SUFU); titrate to 50 mg if allowed. If response is inadequate, consider vibegron, an antimuscarinic or combination, or third-line referral.

Sources

Checked October 15, 2026.

Mirtazapine (Remeron)Depression

What to say

For your depression, start mirtazapine 15 milligrams once each evening before bed. You can take it with or without food. It can make you sleepy fairly early, but improvement in mood takes several weeks. We’ll review how you’re doing before changing the dose.

Sleepiness, increased appetite, weight gain or dizziness can happen. Avoid alcohol and check before combining it with sleep medicines. Don’t drive until you know its effect. Call the same day for new thoughts of self-harm, marked agitation, or unusually high energy with little need for sleep. If you can’t stay safe, call 911. You can also call or text 988 for crisis support. Contact us the same day for fever with a sore throat or mouth sores, which rarely can signal a blood-cell problem. We’ll check in within one to two weeks, sooner if needed. Don’t stop suddenly without a reduction plan.

Clinical reference

Dose options

Major depressive disorder

Start 15 mg orally once daily, preferably before sleep

This is the depression starting dose, not an insomnia dose.

Titration/maximum

Increase only after allowing at least 1–2 weeks at a dose; maximum 45 mg/day

Use response and tolerability rather than automatic increases.

Renal/hepatic impairment

Dose reduction may be needed

Clearance falls with moderate/severe renal or hepatic impairment; individualize and monitor.

Before prescribing

Assess bipolarity/suicide risk, weight/metabolic priorities, sodium risk, liver/renal function and QT/serotonergic interactions. Observe MAOI contraindication and washout requirements.

Side effects and return precautions

Sedation, appetite/weight gain and dizziness; rare neutropenia/agranulocytosis, severe rash, mania, hyponatremia or serotonin syndrome need directed assessment.

Follow-up

Early safety/tolerability review; use one week for younger adults or increased suicide risk when indicated. Track mood/function and weight; taper for ordinary discontinuation.

Sources

Checked September 20, 2026.

Misoprostol (Cytotec) with mifepristoneEarly pregnancy loss

What to say

I’m sorry you’re going through this. The tests confirm that this pregnancy has stopped developing. You can choose waiting, medication or a procedure. You’ve chosen medication. Swallow one 200-milligram mifepristone tablet on [date/time]. Twenty-four hours later, place four 200-microgram misoprostol tablets in the vagina, for a total of 800 micrograms. We’ll give you written instructions and a pain-relief plan.

Expect cramps and bleeding, often heavier than a period, as the tissue passes. Nausea, diarrhea or brief chills can happen. Use pads to track bleeding. Call [24-hour number] urgently if you soak two large pads an hour for two hours, have a temperature of 100.4°F or higher lasting over four hours, or still feel ill more than twenty-four hours after misoprostol. If you can’t reach us, go to the emergency department. Fainting or severe pain needs emergency care. Don’t wait to reach the bleeding threshold.

Contact us if bleeding hasn’t started within forty-eight hours. We’ll check on [date, within 7–14 days] that treatment is complete and discuss how you’re doing. More medicine or a procedure is sometimes needed.

Clinical reference

Dose options

Combination regimen

Mifepristone 200 mg orally, then misoprostol 800 mcg vaginally 24 hours later

Supported by ACOG; SFP also supports 800 mcg vaginally or buccally 7–48 hours after mifepristone. Specify one route and timing.

Misoprostol-only alternative

SFP: at least two doses of 600–800 mcg vaginally or sublingually, at least 3 hours apart

Use a separate written protocol if mifepristone is unavailable; do not mix this schedule into the combination plan.

  • Medication use for early pregnancy loss is off-label in the U.S. This combination regimen is for missed or anembryonic loss with a retained sac; incomplete miscarriage, later gestations and an undiagnosed pregnancy location require a different assessment and plan.
  • ACOG’s 2024 update suggests forgoing routine Rh testing/RhIg before 12 weeks, with individual shared decision-making; use current gestation-specific guidance rather than the older bulletin’s universal RhIg instruction.

Before prescribing

Confirm nonviability and intrauterine location before treatment. Assess stability, bleeding/anemia, infection, anticoagulation, allergies and mifepristone contraindications, including chronic adrenal failure, long-term systemic steroids and inherited porphyria. Arrange emergency access and follow-up.

Side effects and return precautions

Cramping and bleeding are expected; hemorrhage, infection, severe pain or syncope need urgent evaluation. These medicines do not treat ectopic pregnancy.

Follow-up

Agree how completion will be assessed, typically at 7–14 days using symptoms and ultrasound or serial hCG when appropriate. Review absent bleeding, ongoing symptoms and emotional support; offer further medication or aspiration if needed.

Sources

Checked September 24, 2026.

Misoprostol (Cytotec) with mifepristoneMedication abortion

What to say

For this medication abortion, swallow one 200-milligram mifepristone tablet on [date/time]. Twenty-four to forty-eight hours later, put two 200-microgram misoprostol tablets between each cheek and gum, four tablets total. Leave them there for thirty minutes, then swallow any remaining pieces with water. We’ll write down the timing and your pain-relief plan.

Cramping and bleeding are expected, often heavier than a period. Nausea, diarrhea or brief chills can happen. Call [24-hour number] urgently for bleeding that soaks two large pads an hour for two hours, fever of 100.4°F or higher lasting over four hours, or abdominal discomfort or feeling ill more than twenty-four hours after misoprostol. If you can’t reach us, go to the emergency department. Fainting or severe pain needs emergency care immediately.

Keep our follow-up on [date, 7–14 days after mifepristone] even if you bleed. Bleeding alone doesn’t confirm that the abortion is complete. Call if you have no bleeding after misoprostol or still feel pregnant. We’ll discuss additional treatment if needed.

Clinical reference

Dose options

FDA-labeled combination

Mifepristone 200 mg orally once; 24–48 hours later misoprostol 800 mcg buccally

Four 200-mcg tablets: two in each cheek for 30 minutes, then swallow remnants. Through 70 days from the first day of the last menstrual period.

  • This covers the combination regimen, not a misoprostol-only or later-gestation protocol.
  • ACOG suggests forgoing routine Rh testing/RhIg before 12 weeks; individualize through shared decision-making using current guidance.

Before prescribing

Assess gestational age and ectopic risk; evaluate uncertain dating/location as indicated. Exclude suspected ectopic pregnancy, remove any IUD first, and review adrenal failure, long-term systemic steroids, anticoagulation/bleeding disorder, inherited porphyria and allergies. Assess anemia and emergency access. Follow applicable mifepristone REMS requirements.

Side effects and return precautions

Expected bleeding/cramping can overlap with hemorrhage or infection; use explicit return precautions. Ectopic pregnancy is not treated. Persistent pregnancy requires prompt counseling and further care.

Follow-up

The label advises follow-up 7–14 days after mifepristone, with completion assessed by history, examination, hCG or ultrasound. Arrange treatment for incomplete or ongoing pregnancy; offer contraception if desired.

Sources

Checked September 24, 2026.

Molnupiravir (Lagevrio)COVID-19 when Paxlovid isn’t an option

What to say

You have COVID with a higher chance of serious illness, and Paxlovid isn’t a good fit, so we’re using molnupiravir. It may lower the chance of hospital care, though its benefit is less certain than Paxlovid’s. Start as soon as possible, within 5 days of your first symptoms. Take 4 capsules (800 milligrams) every 12 hours for 5 days. If a dose is under 10 hours late, take it; otherwise skip it.

Diarrhea, nausea and dizziness can happen. It may harm a developing baby, so it isn’t used in pregnancy. Use reliable birth control during treatment and for 4 days after if you could become pregnant, or for at least 3 months after if your partner could. Don’t breastfeed until 4 days after the last dose. Stop it and call 911 for face or throat swelling; also call 911 for severe trouble breathing, chest pain or new confusion. Call us if symptoms worsen or return.

Clinical reference

Dose options

Adults ≥18 at high risk, mild to moderate COVID-19 (EUA)

800 mg (four 200-mg capsules) orally every 12 hours for 5 days

Start as soon as possible and within 5 days of symptom onset. Not authorized for >5 consecutive days, pre- or post-exposure prophylaxis, or starting in patients hospitalized for COVID-19. No renal or hepatic adjustment (IDSA). Missed dose: take if <10 hours late; otherwise skip.

Pregnancy, contraception and lactation

Not recommended in pregnancy. Contraception during treatment and for 4 days after (people who can become pregnant) or ≥3 months after (males with partners who can become pregnant)

Assess pregnancy status when clinically indicated; pregnancy needs a different plan. Breastfeeding is not recommended during treatment and for 4 days after the last dose.

  • Not FDA-approved: EUA only, for high-risk adults when FDA-approved or authorized alternatives aren’t accessible or clinically appropriate. HHS has terminated the COVID-19 drug EUA declaration effective June 29, 2027; the EUA stands until then unless revoked.

Before prescribing

Confirm age ≥18, high risk, symptoms ≤5 days and no hospitalization for COVID-19. Use only when Paxlovid (interactions, renal or hepatic limits) and outpatient remdesivir aren’t accessible or appropriate. Check pregnancy status and contraception; no significant drug interactions identified.

Side effects and return precautions

Diarrhea, nausea, dizziness; hypersensitivity including anaphylaxis (stop). Deterioration needs reassessment regardless of antiviral use. IDSA notes uncertain benefit and theoretical mutagenesis concerns, especially in immunocompromised patients.

Follow-up

Check in during the 5-day course; reassess worsening or recurrent symptoms. No extension or repeat course. EUA requirement: report serious adverse events and medication errors to FDA MedWatch within 7 calendar days.

Sources

Checked October 15, 2026.

Montelukast (Singulair)Allergic rhinitis after other treatments fail

What to say

Because other allergy treatments haven’t worked well enough or caused problems for you, we’re trying montelukast 10 milligrams once daily for nasal allergy symptoms. We’ve discussed its risks and alternatives. Take it at a consistent time. If you also have asthma, use the evening schedule and don’t take a second daily dose.

Stop montelukast and contact us immediately for new nightmares, agitation, depression or other mood or behavior changes, including thoughts of self-harm. These can occur without any previous mental-health problem and sometimes continue after stopping. If you can’t stay safe, call 911. Headache or stomach upset can also happen.

Clinical reference

Dose options

Adult allergic rhinitis

10 mg orally once daily

Reserve for inadequate response or intolerance to alternative therapies. With coexisting asthma, take the single daily dose in the evening.

Before prescribing

Document alternatives tried or not tolerated and shared discussion of boxed neuropsychiatric risk. Review psychiatric history and current symptoms; events can occur without prior history.

Side effects and return precautions

Headache/GI symptoms; serious neuropsychiatric effects require stopping and immediate contact. Symptoms can persist or occur after discontinuation.

Follow-up

Review nasal symptoms and adverse effects within 2–4 weeks; stop if there is no meaningful benefit. Neuropsychiatric symptoms require stopping and immediate contact.

Sources

Checked September 23, 2026.

Montelukast (Singulair)Asthma maintenance

What to say

We’re adding montelukast 10 milligrams each evening to help prevent asthma symptoms alongside your inhaler treatment. Take it with or without food. Keep using the inhalers in your breathing plan. This tablet won’t relieve an asthma attack.

Headache or stomach discomfort can happen. The most important warning is a change in sleep, mood or behavior, including vivid dreams, agitation, depression or thoughts of self-harm. Stop montelukast and contact us immediately if these appear, even if you have never had a mental-health problem. If you can’t stay safe, call 911. Tell us if symptoms continue after stopping. We’ll review your breathing and whether it’s helping in about a month. Severe breathlessness or rescue medicine that isn’t helping as your plan says it should means call 911.

Clinical reference

Dose options

Adult asthma

10 mg orally each evening

Continue the prescribed ICS-containing asthma strategy; not rescue treatment.

Before prescribing

Review psychiatric history, current symptoms and the reason an LTRA is appropriate. Discuss the boxed warning and supply the Medication Guide; events can occur without psychiatric history.

Side effects and return precautions

Headache/GI symptoms; serious neuropsychiatric effects require stopping and immediate contact. Symptoms can persist or occur after discontinuation.

Follow-up

Review efficacy and tolerability in 2–4 weeks, earlier for any behavioral or sleep change. Confirm that preventive inhalers and rescue access remain adequate.

Sources

Checked September 23, 2026.

Montelukast (Singulair)Exercise-induced bronchoconstriction prevention

What to say

For the exercise-related breathing symptoms we’ve assessed, take montelukast 10 milligrams at least two hours before exercise. Don’t take a second dose within 24 hours. If you already take montelukast every day, don’t add an extra exercise dose. Keep your rescue inhaler available. This tablet won’t stop an attack.

Stop montelukast and contact us immediately for new nightmares, agitation, depression or other mood or behavior changes, including thoughts of self-harm. These can occur without any previous mental-health problem and sometimes continue after stopping. If you can’t stay safe, call 911. Headache or stomach upset can also happen.

Clinical reference

Dose options

Adult exercise prevention

10 mg orally at least 2 hours before exercise

No additional dose within 24 hours. Patients already taking daily montelukast should not add a pre-exercise dose.

Before prescribing

Confirm exercise-induced bronchoconstriction and assess asthma control and alternative treatments. Review psychiatric history and current symptoms, daily montelukast use and access to rescue treatment. Discuss the boxed warning.

Side effects and return precautions

Headache/GI symptoms; serious neuropsychiatric effects require stopping and immediate contact. Symptoms can persist or occur after discontinuation.

Follow-up

Review exercise symptoms, rescue use and neuropsychiatric effects within 2–4 weeks. Persistent symptoms need reassessment of diagnosis and asthma control.

Sources

Checked September 23, 2026.

Mupirocin 2% ointment (Bactroban)Localized impetigo

What to say

For these small areas of impetigo, the superficial bacterial skin infection, apply a small amount of mupirocin 2% ointment three times a day for [number of days, up to ten]. Use a clean cotton swab or gauze, and wash your hands before and afterward. You may cover it with clean gauze if needed.

This ointment is for the skin, not inside the nose, mouth or eyes. Don’t layer other creams over the same area unless we have agreed on them. Mild burning, stinging or itching can occur. Stop and contact us if irritation becomes strong or a new rash develops. Trouble breathing or tongue swelling means call 911. Call the same day if redness spreads, pain increases or fever develops. If it isn’t improving within three to five days, contact us so we can reassess the diagnosis and treatment.

Clinical reference

Dose options

Localized impetigo

2% ointment: small amount to affected skin three times daily, up to 10 days

Specify the course and reassess nonresponse within 3–5 days; the wording above follows the product label.

Route/formulation

Cutaneous ointment only

Not intranasal, ophthalmic or mucosal treatment; do not extrapolate to a decolonization regimen.

Before prescribing

Confirm limited impetigo; extensive disease, abscess or systemic illness may need another approach. PEG ointment base is a concern on large open areas, especially with renal impairment.

Side effects and return precautions

Burning/itching; stop for marked local irritation or allergy. Worsening infection needs reassessment rather than extending topical treatment.

Follow-up

Check clinical response by 3–5 days and course completion. Do not maintain mupirocin as routine prophylaxis or repeatedly refill without examining recurrent lesions.

Sources

Checked September 20, 2026.

Naloxone nasal spray (Narcan)Opioid overdose rescue

What to say

Keep this naloxone where people around you can find it, and show them how to use it. It’s for a suspected opioid overdose: someone who won’t wake up or is breathing very slowly or not normally.

Give one 4-milligram spray into one nostril. Don’t test or prime it. Each device contains one dose. Call 911 immediately. If the person doesn’t respond or becomes very sleepy again, give another dose with a new device every two to three minutes, alternating nostrils, until help arrives. Follow the dispatcher’s instructions for rescue breathing or CPR. If they’re breathing normally, place them on their side and stay with them. Naloxone can wear off before the opioid does, so emergency care is still needed even if they wake up. It can cause sudden withdrawal, including nausea, sweating and agitation.

Clinical reference

Dose options

Narcan 4-mg nasal device

One spray in one nostril for suspected opioid overdose

Single-use device; no assembly, test spray or priming.

Repeat dosing

New device every 2–3 minutes if inadequate response or recurrent respiratory depression

Alternate nostrils and continue emergency support. More potent/longer-acting opioids may require multiple doses.

Formulation distinctions

Other nasal/injectable naloxone products have different strengths or instructions

Teach the exact dispensed device; possession of naloxone does not make dangerous drug combinations safe.

Before prescribing

Assess overdose risk and access for household/bystanders. Provide multiple doses and demonstrate use. Teach recognition, 911, breathing support and ongoing observation; naloxone is available OTC as well as by prescription.

Side effects and return precautions

Acute withdrawal may include vomiting, diarrhea, pain and agitation. Recurrence of slow breathing can occur after initial response; continue observation and repeat dosing while EMS is coming.

Follow-up

Replace immediately after use or expiration and debrief the event. Offer treatment for opioid use disorder when appropriate and review the pain/sedative regimen without abandoning care.

Sources

Checked September 20, 2026.

Naltrexone (Revia, Vivitrol)Alcohol use disorder

What to say

Naltrexone can lower cravings and make drinking less rewarding, helping you cut down or stop. You can start it while you’re still drinking. Take one 50-milligram tablet once a day, every day, not just on drinking days. It works best with counseling or a support group.

Nausea, headache and dizziness can happen early and often settle. Naltrexone blocks opioids. Don’t start it within 7 to 10 days of any opioid, including pain pills, tramadol or fentanyl, because it can cause sudden, severe withdrawal. Opioid pain and cough medicines won’t work while you take it, so carry a wallet card and tell any clinician. Using extra opioids to overcome the block can be deadly, and after stopping, a once-usual dose can cause an overdose. Stop it and call us for yellow skin or eyes or dark urine. If you might act on thoughts of self-harm, call 911; you can also call or text 988.

Clinical reference

Dose options

Oral naltrexone

50 mg orally once daily

Label dose; trials used 50 mg daily for up to 12 weeks. Can be started while the patient is still drinking (NIAAA); the goal may be reduced drinking or abstinence.

Extended-release injection (Vivitrol)

380 mg deep IM gluteal injection every 4 weeks, alternating buttocks

Label requires that the patient can abstain as an outpatient and is not drinking at the first injection. Give only with the kit’s needles; inadvertent subcutaneous injection raises the risk of severe site reactions.

Opioid-free interval before starting

≥7–10 days after short-acting opioids, including tramadol; up to 2 weeks after buprenorphine or methadone

Contraindicated with opioid analgesics, current opioid dependence, acute withdrawal, a positive urine opioid screen or a failed naloxone challenge.

Before prescribing

Confirm no opioids in the past 7–10 days and none needed soon (pain, surgery); urine opioid screen if unsure. Baseline LFTs; don’t start during acute hepatitis; cirrhosis raises exposure 5–10×. Screen mood; caution in renal impairment.

Side effects and return precautions

Nausea, headache, dizziness, fatigue. Stop for hepatitis symptoms. Precipitated withdrawal if opioid-dependent; overdose risk after stopping or missed doses. Depression and suicidality reported. Vivitrol: injection-site necrosis, eosinophilic pneumonia, hypersensitivity.

Follow-up

Reassess drinking, adherence and side effects within a few weeks, then regularly; check LFTs if symptoms. If no benefit, try another AUD medicine. Offer naloxone if opioid use is possible.

Sources

Checked October 15, 2026.

Naltrexone extended-release injection (Vivitrol)Opioid use disorder

What to say

This shot blocks opioids’ effects for about 4 weeks, helping prevent a return to use. You must be off all opioids first, often for 1 to 2 weeks, or it can cause sudden, severe withdrawal; we’ll check your urine and may give a naloxone test dose. We give 380 milligrams deep in a buttock muscle every 4 weeks, switching sides, alongside counseling and support.

Your tolerance to opioids drops, so using opioids to get past the block, after a missed or late shot, or after stopping can cause a fatal overdose. Keep naloxone at home and show others how to use it; for an overdose, call 911. A sore lump at the shot site is common; call us if it worsens, hardens or opens. Call the same day for yellow skin or eyes, dark urine, low mood or thoughts of self-harm. Tell every clinician about this shot, because opioid pain medicines won’t work normally.

Clinical reference

Dose options

OUD relapse prevention after opioid withdrawal

380 mg deep IM gluteal injection every 4 weeks (or once a month), alternating buttocks

Use only the needles supplied in the carton. ASAM 2020: some patients (faster metabolism) may benefit from dosing every 3 weeks.

Before the first injection

Label: opioid-free ≥7–10 days; up to 2 weeks after buprenorphine or methadone. ASAM 2020: about 6 days after short-acting and 7–10 days after long-acting opioids

Require a negative urine opioid screen; use a naloxone challenge if uncertain. Contraindicated with opioid analgesics, current physiologic dependence or acute withdrawal.

  • VA/DoD 2021 recommends buprenorphine/naloxone or methadone and suggests XR-naltrexone. In X:BOT (per ASAM 2020), induction failures made XR-naltrexone less effective overall, but outcomes were similar once started.

Before prescribing

Confirm OUD, patient preference and opioid-free status; no opioid analgesics expected soon (e.g., planned surgery). Check LFTs or hepatitis, thrombocytopenia or coagulopathy, depression or suicidality, pregnancy and body habitus for needle length.

Side effects and return precautions

Overdose after missed doses, discontinuation or attempts to overcome blockade; precipitated withdrawal; injection-site reactions (induration, abscess, necrosis, some needing surgery); hepatitis; depression or suicidality; eosinophilic pneumonia; hypersensitivity.

Follow-up

Schedule injections every 4 weeks with outreach for missed doses; inspect the previous site. Offer naloxone at each visit, watch mood and liver symptoms, and revisit agonist treatment if cravings or use persist.

Sources

Checked October 15, 2026.

Naltrexone/bupropion ER (Contrave)Weight management

What to say

This tablet combines naltrexone and bupropion to curb appetite and cravings, alongside changes in eating and activity. Week 1: 1 tablet each morning. Week 2: add 1 in the evening. Week 3: take 2 in the morning. From week 4: 2 tablets twice a day. Swallow tablets whole, and don’t take them with a high-fat meal. If you haven’t lost at least 5% of your weight after 12 weeks on the full dose, we’ll stop it.

Nausea, constipation and headache are common. It can raise blood pressure and pulse; we’ll check them. It blocks opioid pain medicines; tell every clinician, and never take extra opioids to overcome it, which can be fatal. Don’t drink heavily or suddenly stop alcohol or sedatives. Call 911 for a seizure. Call us promptly for worsening mood or unusual thoughts; for thoughts of self-harm, call 988, or 911 if in danger.

Clinical reference

Dose options

Weight management titration (8 mg/90 mg tablets)

Week 1: 1 AM. Week 2: 1 AM + 1 PM. Week 3: 2 AM + 1 PM. Week 4 onward: 2 AM + 2 PM (32/360 mg/day)

Don’t cut, chew or crush; avoid high-fat meals. Stop if <5% weight loss after 12 weeks at the maintenance dose.

Dose limits

Max 1 tablet twice daily with moderate or severe renal impairment, moderate hepatic impairment, or CYP2B6 inhibitors (e.g., clopidogrel)

Not recommended in ESRD or severe hepatic impairment. Allow 14 days between an MAOI and Contrave in either direction.

Before prescribing

Boxed warning: suicidality. Contraindicated: uncontrolled hypertension, seizures, bulimia or anorexia, other bupropion products, chronic opioid or buprenorphine/methadone use, abrupt alcohol/benzodiazepine/antiepileptic discontinuation, MAOIs including linezolid. Screen mood.

Side effects and return precautions

Nausea, constipation, headache, insomnia, dizziness; BP and heart-rate rise (especially first 3 months), seizures, neuropsychiatric effects, hepatotoxicity, angle-closure glaucoma, hypoglycemia with diabetes drugs.

Follow-up

Check BP and pulse at baseline and during titration, and mood at each visit. Weigh at 12 weeks on maintenance; stop if <5% loss. Hold before elective surgery needing opioids.

Sources

Checked October 15, 2026.

Naproxen (Naprosyn)Acute gout flare

What to say

For this gout flare, take naproxen 750 milligrams for the first dose, then 250 milligrams every eight hours until the attack settles, with our stop or review date of [date]. This is the prescription immediate-release naproxen schedule. It treats the inflammation now. It doesn’t lower uric acid. Keep taking your prescribed long-term gout medicine.

Don’t combine it with ibuprofen or another anti-inflammatory pain medicine. Check with us if you take aspirin or a blood thinner. Stop and call the same day for significant stomach pain or much less urine. Black stools or vomiting blood means stop it and go to the emergency department. For chest pressure or severe breathing trouble, stop it and call 911. We’ll review whether you still need it on [date]. Fever or a rapidly worsening hot joint needs same-day assessment because infection can resemble gout.

Clinical reference

Dose options

Acute gout, immediate-release naproxen

750 mg initially, then 250 mg every 8 hours until the attack subsides

Specify a stop/review date and use the shortest necessary course. Do not substitute OTC naproxen sodium, delayed-release or extended-release schedules.

Before prescribing

Confirm gout and exclude septic arthritis. Review kidney function, GI bleeding/ulcer, cardiovascular/HF risk, BP, volume status, anticoagulants and other NSAIDs; consider gastroprotection. Avoid around 30 weeks of pregnancy and later; limit use from 20 weeks under clinician guidance.

Side effects and return precautions

Dyspepsia, fluid retention, BP elevation, kidney injury, GI bleeding and cardiovascular events. Explicitly distinguish a routine mild upset stomach from bleeding/emergency symptoms.

Follow-up

Review if not improving within 2–3 days; urgent assessment for fever or systemic illness. Stop when the flare resolves and reassess urate-lowering prevention separately.

Sources

Checked September 23, 2026.

Naproxen (Naprosyn)Acute pain

What to say

We can use naproxen for this pain for [planned duration]. The plan is 500 milligrams for the first dose, then 250 milligrams every six to eight hours only if needed. Don’t take more than 1,250 milligrams in a day under this plan. Take it with food if it upsets your stomach.

Don’t combine it with ibuprofen or another anti-inflammatory pain medicine. Check with us if you take aspirin or a blood thinner. Stop and call the same day for significant stomach pain or much less urine. Black stools or vomiting blood means stop it and go to the emergency department. For chest pressure or severe breathing trouble, stop it and call 911. We’ll review whether you still need it on [date].

Clinical reference

Dose options

Acute pain: naproxen base IR

500 mg initially, then 250 mg every 6–8 hours as needed

Label maximum 1,250 mg/day for this regimen. Use the lowest effective dose for the shortest needed duration.

Other schedules / products

Some inflammatory conditions use 250–500 mg twice daily

Prescription naproxen base, naproxen sodium, delayed-release and OTC products have different instructions; do not mix ceilings.

Renal / pregnancy limits

Avoid if CrCl <30 mL/min

Avoid NSAIDs from 20 weeks of pregnancy unless specifically necessary; avoid at ≥30 weeks. Assess other contraindications and interactions.

Before prescribing

Check renal function, ulcer/GI bleed history, cardiovascular disease/HF, BP, volume status, anticoagulants/antiplatelets and other NSAIDs. Consider gastroprotection based on risk; food does not prevent serious GI bleeding.

Side effects and return precautions

Dyspepsia, fluid retention, BP elevation, kidney injury, GI bleeding and cardiovascular events. Explicitly distinguish a routine mild upset stomach from bleeding/emergency symptoms.

Follow-up

Set a stop/review date tied to the condition. Check BP, renal function and sometimes CBC for ongoing use or risk; earlier review if dehydrated or taking ACE inhibitor/ARB plus diuretic.

Sources

Checked September 20, 2026.

Nicotine gum or lozenge (Nicorette)Smoking cessation

What to say

Nicotine gum or lozenges ease cravings fast and work best with a daily nicotine patch. If you smoke within 30 minutes of waking, use 4 milligrams; otherwise use 2 milligrams. Chew gum slowly until it tingles, then park it between your cheek and gum; chew again when the tingle fades, for about 30 minutes. Let a lozenge dissolve without chewing or swallowing. Don’t eat or drink for 15 minutes before or during use.

With a patch, use one when cravings hit. Without one, use one every 1 to 2 hours for 6 weeks, then fewer, stopping by 12 weeks. Don’t exceed 24 pieces of gum or 20 lozenges a day. Hiccups, heartburn and a sore mouth or jaw are common. Nausea, vomiting, dizziness or a racing heartbeat can mean too much nicotine: stop and call us. Keep pieces away from children and pets. Chest pain or trouble breathing means call 911.

Clinical reference

Dose options

Choosing strength

First cigarette within 30 minutes of waking: 4 mg; later: 2 mg

Same rule for Nicorette gum and lozenge (OTC Drug Facts).

Used alone (label schedule)

Weeks 1–6: 1 every 1–2 h (≥9/day); weeks 7–9: every 2–4 h; weeks 10–12: every 4–8 h

Maximum 24 gum pieces/day; lozenges maximum 5 per 6 h and 20/day. Discuss with a clinician before using beyond 12 weeks.

Combination NRT (preferred)

Daily patch plus gum or lozenge for cravings or before expected triggers

Combining short- and long-acting NRT is more effective than one form (USPSTF 2021). Current Drug Facts don’t bar use with a patch; stay within daily maximums.

Before prescribing

Note time to first cigarette, cigarettes/day and quit date. Ask about recent MI, arrhythmia, uncontrolled hypertension, stomach ulcer, diabetes, seizures, pregnancy and dental or jaw problems. Depression or asthma medicine doses may need adjustment.

Side effects and return precautions

Hiccups, heartburn, nausea, mouth or jaw soreness. Overdose: nausea, vomiting, dizziness, diarrhea, weakness, tachycardia. Stop for palpitations or allergic reaction. Used pieces can poison children and pets.

Follow-up

Contact near the quit date and within 1–2 weeks to review cravings, technique and frequency. Taper over weeks 7–12; longer use with clinician guidance. Offer counseling or 1-800-QUIT-NOW.

Sources

Checked October 15, 2026.

Nicotine patch (NicoDerm CQ)Smoking cessation

What to say

The patch gives a steady amount of nicotine to reduce withdrawal while you stop smoking. Because you smoke more than ten cigarettes a day, we’ll start a 21-milligram patch each morning. Put it on clean, dry, hairless skin, remove yesterday’s patch first, and rotate the location. Don’t cut it.

Our plan is 21 milligrams daily for six weeks, then 14 milligrams for two weeks, then 7 milligrams for two weeks. Mild skin irritation or vivid dreams can happen. Removing it at bedtime can help sleep. Put on a new patch the next morning. If you slip and smoke, you can get back to your quit plan and keep using the patch. Nausea, dizziness or a racing heartbeat can mean too much nicotine: remove the patch and call the same day for advice. Severe chest pain or trouble breathing means call 911. Fold used patches sticky sides together and keep them away from children and pets.

Clinical reference

Dose options

More than 10 cigarettes/day

21 mg/24-hour patch daily ×6 weeks, then 14 mg daily ×2 weeks, then 7 mg daily ×2 weeks

10-week OTC product schedule; other products and guidelines use different durations.

10 or fewer cigarettes/day

14 mg daily ×6 weeks, then 7 mg daily ×2 weeks

Individualize to dependence, withdrawal and product instructions.

Breakthrough cravings

A prescribed short-acting nicotine gum/lozenge plan may accompany the patch

State the chosen dose and maximum separately; do not stack patches without a plan.

Before prescribing

Review tobacco/nicotine use, pregnancy/breastfeeding, recent cardiovascular instability, skin disease/adhesive allergy and planned MRI. Confirm product and nicotine-replacement combination plan.

Side effects and return precautions

Skin irritation, insomnia/vivid dreams; nausea, vomiting, dizziness and tachycardia can signal nicotine excess. Remove and assess suspected toxicity. Used patches remain toxic to children/pets.

Follow-up

Check cravings, smoking and technique within 1–2 weeks and at dose reductions. Persistent skin reaction or uncontrolled withdrawal merits adjustment.

Sources

Checked September 20, 2026.

Nirmatrelvir/ritonavir (Paxlovid)COVID-19 in eligible higher-risk patients

What to say

Because you have COVID and a higher chance of becoming seriously ill, we’re starting Paxlovid within five days of when symptoms began. With the kidney function we’ve checked, take two 150-milligram nirmatrelvir tablets and one 100-milligram ritonavir tablet together, morning and evening, for five days. Swallow them whole, with or without food.

A bitter or metallic taste and diarrhea are common. The most important preparation is checking every medicine and supplement you use. Follow the written list of what to pause or change and when to restart. Don’t make additional changes on your own. If you use a combined birth-control pill, we’ll give you a backup-contraception plan. Call the same day if you can’t keep fluids down. Stop it and call the same day for a new rash. Trouble breathing, chest pain, severe confusion or tongue swelling means call 911. Contact us if symptoms worsen or return after treatment.

Clinical reference

Dose options

eGFR ≥60 mL/min

Nirmatrelvir 300 mg plus ritonavir 100 mg orally twice daily for 5 days

Start as soon as possible and within 5 days of symptom onset in an eligible adult.

eGFR 30 to <60

Nirmatrelvir 150 mg plus ritonavir 100 mg twice daily for 5 days

Specify both component doses and dispense the correct renal pack.

eGFR <30, including hemodialysis

Day 1: nirmatrelvir 300 mg plus ritonavir 100 mg once; days 2–5: 150 mg plus 100 mg once daily

Current U.S. label includes this severe-renal regimen. Give after dialysis on dialysis days; frequency is once daily, not twice.

Hepatic / missed dose

Not recommended in Child-Pugh C. Missed dose within 8 hours: take; >8 hours: skip

Do not double. Check every interaction against current guidance; strong enzyme induction cannot always be managed by a brief hold.

Before prescribing

Confirm adult eligibility, symptom-onset date, renal/hepatic status and complete interaction reconciliation, including OTC/herbals. Some drugs are contraindicated; others need dose changes, temporary holds or an alternative antiviral. Document individualized restart dates. Consider HIV status and pregnancy context.

Side effects and return precautions

Dysgeusia/diarrhea, serious interactions, hypersensitivity and liver injury. Stop and seek immediate care for a severe allergic reaction or blistering/mucosal rash. COVID deterioration needs clinical reassessment regardless of antiviral use.

Follow-up

Provide a contact route during the five-day course and confirm the restart plan for affected medicines. Reassess worsening/recurrent symptoms; no automatic additional course. Label: consider nonhormonal backup during treatment and until one menstrual cycle after stopping for ethinyl-estradiol contraceptive users.

Sources

Checked September 20, 2026.

Nitrofurantoin (Macrobid)Uncomplicated cystitis

What to say

This treatment is for an infection in the bladder. Take nitrofurantoin, the Macrobid formulation, 100 milligrams twice a day with food for five days. It isn’t a treatment for a kidney infection.

Nausea can happen, and the urine may look darker. We expect symptoms to start improving within about two days. Call the same day if you aren’t improving, or if you develop fever, pain in your side or back, or vomiting. For new breathing difficulty, stop it and go to the emergency department now. Severe breathing trouble or new chest pain means call 911. A blistering or peeling rash, or a rash with mouth sores, means stop it and go to the emergency department. If we sent a culture, we’ll tell you whether to continue or change treatment.

Clinical reference

Dose options

Guideline uncomplicated cystitis regimen

Macrobid 100 mg orally twice daily for 5 days

For nonpregnant adult women; the U.S. product label states a 7-day course. Other nitrofurantoin formulations have different schedules.

Renal restriction differs across authorities

Guidelines commonly avoid eGFR <30; the cited U.S. label contraindicates CrCl <60 mL/min

Apply the local guideline/formulary with explicit renal review; do not describe the 30 threshold as the U.S. label.

Not appropriate for

Suspected pyelonephritis, prostatitis or systemic infection

Pregnancy, male UTI and complicated infection require their own assessment and regimen.

Before prescribing

Check lower-tract symptoms, renal function, pregnancy/gestation, G6PD deficiency and previous nitrofurantoin lung/liver reactions. Contraindicated at term (38–42 weeks), labor or imminent labor under the label.

Side effects and return precautions

GI effects; pulmonary, hepatic and neurologic toxicity can occur. Stop and assess new respiratory symptoms or jaundice. Fever/flank pain or vomiting may indicate upper-tract disease; severe illness requires emergency care.

Follow-up

Review lack of improvement within 48 hours and act on culture if ordered. No routine test-of-cure for resolved uncomplicated nonpregnant cystitis.

Sources

Checked September 20, 2026.

Nitroglycerin sublingual tablets (Nitrostat)Acute angina relief

What to say

This 0.4-milligram nitroglycerin tablet is for the angina we’ve diagnosed. Stop activity and sit down, then place one tablet under your tongue and let it dissolve. Don’t chew or swallow it like an ordinary pill.

If the pain isn’t relieved after five minutes, call 911. Don’t drive yourself or wait to finish all three doses. While help is coming, you may repeat a tablet every five minutes, up to three total doses, following your emergency plan. New, unusually severe or different chest pain means call 911 right away. Headache or lightheadedness can happen. Never combine nitroglycerin with sildenafil, tadalafil, other erection medicines, riociguat or poppers. Tell the emergency team what you have taken. Keep tablets in their original tightly closed bottle and check the expiration.

Clinical reference

Dose options

Acute diagnosed angina

0.3–0.6 mg sublingually; the wording above uses 0.4 mg

May repeat every 5 minutes, up to 3 tablets in 15 minutes. The emergency plan calls 911 after an unrelieved first dose; do not delay for dose three.

Before a known trigger

A prescribed dose may be taken 5–10 minutes before an activity that provokes angina

Only after an individualized plan for stable symptoms.

Major contraindications

PDE5 inhibitors, soluble guanylate-cyclase stimulators, severe anemia, increased intracranial pressure or circulatory shock

Usual minimum nitrate-avoidance intervals after sildenafil/vardenafil are 24 hours, tadalafil 48 hours; clearance/context can require longer. Do not treat an interval as authorization to self-dose after chest pain.

Before prescribing

Confirm coronary/angina assessment, BP, drug interactions, symptom stability and safe access to emergency care. Review all ED/pulmonary-hypertension drugs. Avoid routine use for undifferentiated chest pain without assessment.

Side effects and return precautions

Headache, flushing, dizziness and hypotension. Worsening pattern or more frequent rescue use needs prompt review; persistent or new concerning pain is an emergency.

Follow-up

Review angina burden and preventive treatment promptly if rescue use increases; check supply/expiration and repeat the emergency instructions. Distinguish rescue from long-acting nitrate products.

Sources

Checked September 20, 2026.

Norethindrone 0.35 mg (Jencycla, Norlyda, Micronor)Contraception, progestin-only pill

What to say

We’re starting norethindrone 0.35 milligrams for contraception. Take one pill at exactly the same time every day, with no break between packs. Every pill is active. Since you’re starting more than five days after your period began and we’ve checked that pregnancy is unlikely, use condoms or avoid sex for the first two days.

If you’re more than three hours late, take the pill as soon as possible, continue at the usual time, and use condoms for the next two days. Contact us that day about emergency contraception if you’ve had unprotected sex. Irregular bleeding is common and doesn’t mean the pill failed. Call if bleeding is heavy or persistent. Go to the emergency department for severe one-sided lower abdominal pain, especially with a positive pregnancy test. Call 911 if you faint or can’t travel safely. This pill doesn’t protect against sexually transmitted infections. We’ll review how the schedule is working in about two months.

Clinical reference

Dose options

Daily regimen

Norethindrone 0.35 mg orally at the same time every day

All 28 tablets are active; start each new pack immediately. These rules are not the drospirenone-only pill rules.

Starting: CDC guidance

Within five days after bleeding starts: no backup; later: backup for two days

Be reasonably certain the patient is not pregnant; address recent unprotected intercourse.

More than three hours late

Take as soon as possible, continue at the usual time, and use condoms/abstinence until pills have been taken on time for two consecutive days

Two pills in one day may be needed. Assess emergency contraception after unprotected sex; ulipristal requires a separate hormone restart plan.

Vomiting or diarrhea within three hours of a dose

Take another pill as soon as possible; continue daily

Use backup until two days after vomiting/diarrhea resolves. Assess emergency contraception if unprotected sex occurred.

Before prescribing

Check pregnancy risk, ability to maintain exact timing, current breast cancer, significant liver disease and interacting enzyme inducers. Choose a different method if the schedule is unlikely to be workable. This 0.35 mg contraceptive is distinct from norethindrone acetate used for bleeding disorders.

Side effects and return precautions

Irregular bleeding, nausea, breast tenderness and headache may occur. Evaluate heavy/persistent bleeding or pregnancy symptoms. Suspected ectopic pregnancy with severe pain, syncope or instability requires emergency care.

Follow-up

Optional 1–3 month adherence/bleeding review; provide a same-day route for missed-pill and emergency-contraception advice. Recheck pregnancy when indicated by exposure, symptoms or uncertain initiation.

Sources

Checked September 20, 2026.

Norethindrone acetate/ethinyl estradiol (Junel 1/20)Contraception

What to say

For contraception, we’ve checked that an estrogen-containing pill is appropriate for you. Start Junel 1/20 today, the first day of your period. Take one active tablet at the same time daily for 21 days, then have seven pill-free days and start the next pack on time. You don’t need backup for this day-one start. It doesn’t protect against sexually transmitted infections.

Spotting, nausea or breast tenderness often improve over the first few months. If one pill is late or missed by less than 48 hours, take it when remembered and continue. If two or more active pills are missed, follow our written missed-pill instructions and use condoms for seven days. Contact us promptly about emergency contraception if needed. Stop and call 911 for chest pain, sudden breathlessness, a drooping face, arm weakness or trouble speaking. A new migraine aura needs prompt assessment. We’ll review bleeding and blood pressure in about three months.

Clinical reference

Dose options

21-day pack

Norethindrone acetate 1 mg / ethinyl estradiol 20 micrograms: one active pill daily for 21 days, then seven pill-free days

Start the next pack on day 29 regardless of bleeding. Junel Fe has inactive tablets instead of the pill-free interval; do not confuse packs.

Starting: CDC guidance

Within five days after menstrual bleeding starts: no backup; later start: condoms/abstinence for seven days

Be reasonably certain the patient is not pregnant and consider recent unprotected intercourse. The wording above starts on day one.

One late/missed active pill: <48 hours

Take as soon as remembered and continue the pack, even if two pills on one day

No additional contraception is generally needed.

At least two consecutive active pills missed: ≥48 hours

Take the most recent missed pill, discard earlier missed pills, continue daily; backup until seven consecutive active pills taken

If missed in the last active week, omit the pill-free week and start a new pack. If first-week pills were missed and sex occurred in the prior five days, assess emergency contraception promptly.

Vomiting/diarrhea for ≥48 hours

Continue pills if possible; backup until seven active pills taken after illness resolves

Apply CDC last-week break omission and first-week emergency-contraception assessment. Ulipristal changes when hormones can restart; provide a coordinated plan.

Before prescribing

Measure BP and screen pregnancy, migraine with aura, smoking at age ≥35, thromboembolism/thrombophilia, severe hypertension, early postpartum status, breast cancer and significant liver disease. Review enzyme inducers and lamotrigine. CDC U.S. MEC determines eligibility; do not default to estrogen if contraindicated.

Side effects and return precautions

Spotting, nausea and breast symptoms are common. New aura or substantial headaches require evaluation; clot/stroke symptoms require emergency assessment. CDC missed-pill instructions here may differ from older package instructions, so provide one consistent written plan.

Follow-up

Offer a 2–3 month review for tolerability/adherence and BP, with access sooner for missed pills, emergency contraception or warning symptoms. Routine pelvic examination is not required solely to prescribe combined pills.

Sources

Checked September 20, 2026.

Norgestrel 0.075 mg (Opill)Over-the-counter contraception

What to say

Opill is a progestin-only birth control pill, norgestrel 0.075 milligrams, sold without a prescription. Take 1 tablet at the same time every day, with no break between packs. You can start any day; use condoms for the first 48 hours. If you’re more than 3 hours late or miss a pill, take 1 as soon as you remember, then continue at your usual time, and use condoms for the next 48 hours.

Also use condoms for 48 hours after vomiting or severe diarrhea within 4 hours of a pill. If you had sex without a condom after a late or missed pill, take emergency contraception like Plan B and contact us. Irregular bleeding is common. Seizure, tuberculosis or HIV medicines and St. John’s wort can weaken it. Don’t use it with other hormonal birth control or if you’ve had breast cancer. Severe one-sided belly pain needs emergency care. It doesn’t prevent sexually transmitted infections.

Clinical reference

Dose options

Daily regimen (OTC Drug Facts)

Norgestrel 0.075 mg orally at the same time daily; continuous packs

Start any day with 48 hours of backup. CDC SPR 2024: backup 2 days if started >5 days after bleeding began.

More than 3 hours late, missed, or vomiting

Take 1 tablet ASAP, then resume the usual time; backup 48 hours. Vomiting or severe diarrhea within 4 hours: backup 48 hours

CDC uses 3 hours for vomiting (take another pill) and advises considering EC, not ulipristal, after unprotected sex.

Before prescribing

No prescription needed. Ask about breast or other cancer, liver disease, unexplained bleeding, other hormonal methods, ulipristal in the past 5 days, and inducers (anticonvulsants, rifampin, HIV drugs, bosentan, St. John’s wort).

Side effects and return precautions

Irregular bleeding, headache, dizziness, nausea, increased appetite, cramps or bloating. Evaluate heavy or prolonged bleeding, bleeding after sex, new migraine with aura, jaundice, or one-sided pelvic pain.

Follow-up

Offer a review of adherence and bleeding, advance EC and STI testing. Pregnancy test if a period is late after missed pills or absent for 2 months.

Sources

Checked October 15, 2026.

Nortriptyline (Pamelor)Depression

What to say

Nortriptyline is an older antidepressant, usually used after newer ones haven’t helped. Take 25 milligrams once a day at bedtime. If side effects are manageable, we’ll raise it about weekly, usually to 75–100 milligrams a day. Full benefit can take 6 weeks or longer. A blood test may help set the dose.

Dry mouth, constipation, sleepiness and dizziness are common. Get up slowly, limit alcohol, and don’t drive until you know how it affects you. Call us for trouble passing urine. Get same-day care for a racing or irregular heartbeat, eye pain with blurred vision, worsening thoughts of self-harm, or very high energy with little sleep. Call 911 for fainting, a seizure, or if you might act on those thoughts; 988 offers crisis support. An overdose can be deadly, so we’ll prescribe small amounts. Don’t add amitriptyline, other antidepressants, bupropion or tramadol without checking, and don’t stop suddenly.

Clinical reference

Dose options

Adult depression

25 mg once daily (bedtime); increase by 25–50 mg weekly as tolerated; usual 75–100 mg/day; maximum 150 mg/day

Label: usual 25 mg 3–4 times daily or the total once daily; titration per VA/DoD 2022. Above 100 mg/day, check plasma levels and keep 50–150 ng/mL.

Older adults; hepatic impairment

Label: 30–50 mg/day, once daily or divided. VA/DoD: start 10–25 mg/day; hepatic: lower dose, slower titration; no renal change

AGS Beers 2023: avoid in older adults (strongly anticholinergic, sedating, orthostatic hypotension), though VA/DoD rates nortriptyline among the better-tolerated TCAs. If used, monitor rhythm, BP and sodium.

CYP2D6 inhibitors and MAOIs

Fluoxetine, paroxetine, bupropion, quinidine or cimetidine can make a stable patient abruptly toxic; may need a lower dose and a plasma level

A higher dose may be needed when the inhibitor stops. After stopping fluoxetine, ≥5 weeks may be needed before starting. ≥14 days between an MAOI and nortriptyline either way; don’t start during linezolid or IV methylene blue.

  • VA/DoD 2022 suggests against TCAs as initial treatment; consider after an inadequate response. Nortriptyline is amitriptyline’s active metabolite, so never combine them. The amitriptyline cards use low off-label doses for pain, migraine or IBS; this card uses full antidepressant doses.

Before prescribing

Boxed warning: screen suicide risk and limit supply; screen bipolar history. ECG first with heart disease, syncope or family history of sudden death; contraindicated in acute post-MI recovery; avoid with suspected Brugada. Check narrow angles, urinary retention, seizures, thyroid disease or medication, pregnancy (safety not established).

Side effects and return precautions

Dry mouth, constipation, urinary retention, blurred vision, sedation, orthostasis and falls, confusion in older adults, tachycardia, conduction delay, seizures, SIADH, angle closure, serotonin syndrome, mania, suicidality. Overdose can be fatal (arrhythmia, hypotension, seizures, coma).

Follow-up

Early safety check, then weekly titration. Plasma level above 100 mg/day or when adding or stopping a CYP2D6 inhibitor. Judge response after 4–6 weeks at a maximized dose (VA/DoD). Taper when stopping; abrupt cessation can cause nausea, headache, malaise.

Sources

Checked October 21, 2026.

O–Z

Olmesartan (Benicar)Hypertension

What to say

We’ll start olmesartan 20 milligrams once a day to lower your blood pressure. Take it with or without food and keep a home blood-pressure log. We’ll check kidney function and potassium after starting and use those results and your readings to decide whether the dose needs to change.

Dizziness can happen, especially when standing. Check with us before using potassium supplements, potassium salt substitutes or regular ibuprofen or naproxen. Contact us for persistent diarrhea or unexplained weight loss, even if you have taken this medicine for months. If you become pregnant, stop it and call us right away. Let’s know before trying to conceive.

Clinical reference

Dose options

Adult hypertension

Start 20 mg orally daily; may increase to 40 mg daily after 2 weeks

Correct volume depletion first; consider a lower supervised starting dose when depleted. Maximum 40 mg/day.

Before prescribing

Check BP, creatinine/eGFR, potassium, pregnancy plans and volume status. Review NSAIDs, lithium, potassium-raising drugs and duplicate ACE inhibitor/ARB therapy; aliskiren is contraindicated with diabetes.

Side effects and return precautions

Hypotension, hyperkalemia, kidney injury and rare sprue-like enteropathy. Fainting or very low urine output requires prompt assessment; breathing trouble or facial/tongue swelling is an emergency.

Follow-up

Arrange BP and kidney/potassium review in about 1–2 weeks, sooner with renal or volume risks, and after dose changes.

Sources

Checked September 23, 2026.

Olopatadine eye drops (Pataday)Allergic conjunctivitis

What to say

Olopatadine (Pataday) eye drops relieve itchy eyes from allergies, and you can buy them without a prescription. For the 0.2% or 0.7% strength, put 1 drop in each affected eye once a day. The 0.1% strength is 1 drop twice a day, 6–8 hours apart. Take out contact lenses first and wait at least 10 minutes before putting them back. Wait 5 minutes between different eye drops, and don’t touch the tip to anything. Cold compresses and not rubbing your eyes also help.

The drops can sting briefly. Stop them and call us if your eyes get redder, itching worsens or lasts more than 72 hours, or your vision changes. Eye pain, sensitivity to light or reduced vision needs an eye exam the same day. Don’t wear contact lenses while your eye is red, and don’t use these drops for irritation caused by your lenses.

Clinical reference

Dose options

Pataday Once Daily Relief 0.2% or Extra Strength 0.7%

1 drop in each affected eye once daily; no more than 1 drop per eye per day

OTC for adults and children 2 and older. Remove contacts first and wait at least 10 minutes before reinserting; wait at least 5 minutes between eye products.

Pataday Twice Daily Relief 0.1% (and generic olopatadine 0.1%)

1 drop in each affected eye twice daily, 6–8 hours apart; no more than twice per day

Same contact lens and eye-product spacing advice. Ketotifen 0.025% (Zaditor, Alaway) is an OTC alternative dosed twice daily (AAO).

  • AAO notes oral antihistamines can worsen dry eye, and long-term vasoconstrictor eye drops can cause rebound redness.

Before prescribing

Confirm itching with watery discharge and no pain, light sensitivity, vision loss or purulent discharge. Ask about contact lens wear, recent eye surgery or herpes simplex eye history, and sensitivity to ingredients.

Side effects and return precautions

Brief stinging or burning, headache, dry eye, blurred vision. Eye pain, photophobia, reduced vision, corneal findings, severe discharge or no response to therapy needs ophthalmology (AAO).

Follow-up

Review response at the next visit. Return sooner if itching lasts over 72 hours or redness rises. Add cold compresses and trigger avoidance; persistent or recurrent cases need an eye exam.

Sources

Checked October 15, 2026.

Omeprazole (Prilosec)Reflux symptoms, short treatment trial

What to say

I suggest a short trial of omeprazole 20 milligrams each morning, 30 to 60 minutes before breakfast. Take it daily during the trial, rather than only when the burning starts. It isn’t an immediate-relief medicine.

If we’re checking for H. pylori, the stomach bacterium, we’ll coordinate the test before the medicine affects the result. Otherwise, we’ll check how much the treatment has helped at four weeks and decide whether to stop, continue for a defined period or investigate further. Headache, nausea, gas or loose stools can occur. Call sooner for trouble swallowing, persistent vomiting or unintentional weight loss. Vomiting blood or black tarry stools needs emergency care. You don’t need routine extra calcium, magnesium or B12 simply for this short trial.

Clinical reference

Dose options

Standard trial

20 mg orally once daily before breakfast

For GERD or dyspepsia; check formulation and indication.

Duration examples

Label: symptomatic GERD up to 4 weeks; erosive esophagitis 4–8 weeks

A clinician-directed dyspepsia trial may use a four-week standard-dose course.

Higher dosing

No single maximum for a short trial

Other indications use different regimens. Reassess indication, timing/adherence and alarm features before escalation.

Before prescribing

Review alarm features, NSAIDs and interactions, especially clopidogrel. Coordinate H. pylori testing/required washout. Dose and duration vary with indication; symptom response is not proof of an acid-only diagnosis.

Side effects and return precautions

Common GI effects/headache. Urgent: bleeding, progressive swallowing problems, persistent vomiting, severe diarrhea or possible renal reaction. Do not portray observational long-term associations as proven causal harms.

Follow-up

Review at four weeks and set an explicit endpoint by 4–8 weeks. Discuss rebound and a stop/taper plan when appropriate; no routine vitamin labs solely for short use.

Sources

Checked September 20, 2026.

Ondansetron ODT (Zofran ODT)Nausea and vomiting from gastroenteritis, off-label

What to say

For the nausea and vomiting from the stomach illness we assessed today, use one ondansetron 4-milligram dissolving tablet up to every eight hours if needed for the next twenty-four hours, with no more than three doses in that time. The aim is to help you keep fluids down. With dry hands, peel back the packet, place the tablet on your tongue and let it dissolve. You don’t need water to take it.

Keep taking small, frequent sips of oral rehydration solution. Headache or constipation can happen. If you still can’t keep fluids down, are passing very little urine or aren’t improving by tomorrow, call for same-day reassessment. Severe or increasing belly pain, a swollen belly or blood in vomit means go to the emergency department. Stop it and go to the emergency department for a new racing or irregular heartbeat. Fainting or chest pain means call 911. Don’t keep extending the course without review.

Clinical reference

Dose options

Short outpatient trial

4 mg ODT orally every 8 hours as needed for 24 hours

A limited course for assessed vomiting from acute gastroenteritis; off-label in the U.S. Reassess by the next day rather than repeating indefinitely.

Source regimen

Emergency Care BC lists 4–8 mg orally every 8 hours as needed to facilitate adult oral rehydration

The source is an adult emergency-care summary, not an FDA gastroenteritis indication or a mandated outpatient duration.

Severe hepatic impairment

Total daily ondansetron maximum 8 mg

The every-8-hour course above needs modification. Oncology, radiotherapy and perioperative regimens are separate.

Before prescribing

Assess hydration, pregnancy, abdominal red flags, QT/arrhythmia history, potassium/magnesium and interacting QT/serotonergic drugs. Avoid congenital long-QT syndrome; concomitant apomorphine is contraindicated. ECG/electrolyte evaluation is risk-based.

Side effects and return precautions

Headache/constipation; QT-related arrhythmia and serotonin syndrome are important risks. Symptom suppression must not delay evaluation of obstruction or worsening illness.

Follow-up

Confirm ability to drink and a next-day contact plan. Persistent vomiting, oliguria or deterioration needs assessment, not another open-ended prescription.

Sources

Checked September 20, 2026.

Orforglipron (Foundayo)Weight management

What to say

For weight management alongside food and activity changes, take Foundayo once a day at any time, with or without food. Swallow it whole. Start with 0.8 milligrams, then 2.5 and 5.5 milligrams, each for at least 30 days. We may go higher, up to 17.2 milligrams, based on benefit and side effects. Take a missed dose when you remember, but never 2 in 1 day. If you miss 7 or more days, call us before restarting. Ask us about the current cost.

Nausea, constipation, diarrhea and vomiting are common, especially after an increase. Call the same day if you can’t keep fluids down. Severe, lasting belly pain means stop it and go to the emergency department. If you use birth-control pills, add condoms or switch methods for 30 days after starting and after each increase. Tell us about medullary thyroid cancer or MEN2 in you or your family, pregnancy plans, anesthesia and all medicines. Stop it if you become pregnant.

Clinical reference

Dose options

Foundayo: weight reduction

0.8 mg daily ≥30 days → 2.5 mg ≥30 days → 5.5 mg; may increase to 9, 14.5, then 17.2 mg, each after ≥30 days

Maximum 17.2 mg daily. One tablet daily, any time, with or without food. Trial doses of 6, 12 and 36 mg correspond to 5.5, 9 and 17.2 mg.

Missed doses

Take as soon as possible; never 2 doses in 1 day. After ≥7 consecutive missed doses, restart escalation at a lower dose

No renal adjustment, including ESRD. Not recommended in Child-Pugh C.

Interactions

Strong CYP3A4 inhibitor: maximum 9 mg. Avoid ritonavir-containing regimens and strong CYP3A4 inducers. Simvastatin ≤20 mg

Moderate inducers such as efavirenz: monitor effect and escalate as needed. Oral contraceptives: non-oral method or barrier for 30 days after starting and each increase.

  • Approved April 1, 2026. A small-molecule oral GLP-1 receptor agonist without fasting or water rules; its thyroid C-cell boxed warning is class-based, since orforglipron is inactive in rodents.

Before prescribing

Confirm adult eligibility. Contraindicated with personal or family MTC, MEN2 or serious hypersensitivity. Review pregnancy plans and contraception, breastfeeding (not recommended), severe gastroparesis, pancreatitis, gallbladder disease, retinopathy, insulin or sulfonylureas, CYP3A4 drugs and other GLP-1 products.

Side effects and return precautions

Dose-related GI effects, dehydration and AKI, pancreatitis, gallbladder disease, hypoglycemia with insulin or sulfonylureas, hypotension with antihypertensives, tachycardia, hair loss, hypersensitivity and aspiration risk with anesthesia.

Follow-up

Review tolerance and weight before each step; go past 5.5 mg only for response and tolerability. Reassess if weight loss is inadequate. Stop when pregnancy is recognized; the label sets no preconception washout.

Sources

Checked October 15, 2026.

Oseltamivir (Tamiflu)Flu prevention after exposure

What to say

Because of this flu exposure and your risk, we’ve chosen preventive oseltamivir. Take 75 milligrams once a day through [stop date]. Our plan continues for seven days after your last exposure, so tell us if close contact continues. Start promptly. Prevention works best when begun within 48 hours of exposure.

Take it with food if you feel nauseated. If fever, cough or body aches begin, contact us the same day: the prevention dose is different from treatment. Don’t double the dose yourself. Prevention lowers risk but doesn’t guarantee you won’t get flu or replace vaccination. Severe breathing trouble, chest pain or confusion needs emergency care.

Clinical reference

Dose options

Asymptomatic exposed adult, CrCl >60

75 mg orally once daily for 7 days after the last exposure under CDC guidance

U.S. labeling specifies at least 10 days after close contact. Choose and document the stop date; ongoing exposure and institutional outbreaks require a different duration.

Renal adjustment

CrCl >30–60: 30 mg daily; >10–30: 30 mg every other day

Use the prophylaxis-specific dialysis schedule when applicable; not recommended in ESRD without dialysis.

Before prescribing

Confirm no current flu symptoms, exposure timing, renal function and a reason for prophylaxis. An early-treatment plan is an alternative for many contacts. Review pregnancy and live intranasal vaccine timing.

Side effects and return precautions

Nausea, vomiting and headache; stop and seek urgent care for serious allergy or blistering rash. New flu symptoms require reassessment.

Follow-up

Confirm the final exposure date and stop date. If illness develops during prophylaxis, reassess treatment and possible resistance rather than simply continuing once-daily dosing.

Sources

Checked September 23, 2026.

Oseltamivir (Tamiflu)Flu treatment

What to say

For this flu illness, take oseltamivir 75 milligrams twice a day for five days. It works best when started early and can shorten the illness. Some people still benefit when treatment starts later, particularly if they’re at higher risk or getting seriously ill. Take it with food if it causes nausea.

Vomiting or headache can happen. Call if you can’t keep fluids down or are worsening after initially improving. New confusion, severe breathing trouble or persistent chest pain needs emergency care. A blistering rash or swelling after a dose also needs urgent assessment. This medicine doesn’t replace your flu vaccine.

Clinical reference

Dose options

Adult treatment, CrCl >60 mL/min

75 mg orally twice daily for 5 days

Start promptly; do not delay priority treatment while awaiting a test.

Renal adjustment

CrCl >30–60: 30 mg twice daily; >10–30: 30 mg daily, each for 5 days

Dialysis requires its specific label regimen. Not recommended in ESRD without dialysis.

Before prescribing

Assess severity, symptom onset, renal function, pregnancy and risk factors. Oseltamivir is preferred in pregnancy. Hospitalized, severe/progressive and high-risk patients warrant prompt treatment even after 48 hours; assess the appropriate care setting.

Side effects and return precautions

GI effects, uncommon serious skin/allergic reactions and abnormal behavior. Influenza can still cause pneumonia or other complications.

Follow-up

Reassess deterioration or persistent symptoms. Review recent/planned live intranasal flu vaccination because antivirals can reduce its effectiveness.

Sources

Checked September 23, 2026.

Over-the-counter cold medicines (Sudafed, Delsym, Mucinex)Cold symptoms

What to say

Cold medicines can ease symptoms, but they don’t shorten a cold. For a stuffy nose, pseudoephedrine (real Sudafed, kept behind the pharmacy counter) is 60 milligrams every 4–6 hours, up to 240 milligrams a day. For cough, dextromethorphan (Delsym) is 60 milligrams every 12 hours. Guaifenesin (Mucinex) may loosen mucus. Skip oral phenylephrine, including Sudafed PE; the FDA says it doesn’t relieve congestion.

Pseudoephedrine can raise blood pressure and heart rate and cause jitters or poor sleep. Ask us first if you have high blood pressure, heart disease, thyroid disease, diabetes or an enlarged prostate. Don’t take either with an MAOI medicine or within 2 weeks after stopping one. Combination products often add acetaminophen or a drowsy antihistamine, so read labels and avoid doubling up. Call us if you’re not better in 7 days or have a fever. Call 911 for trouble breathing or chest pain.

Clinical reference

Dose options

Nasal congestion: pseudoephedrine (Sudafed Sinus Congestion)

60 mg (2 × 30 mg tablets) every 4–6 hours, maximum 240 mg/24 hours; or 120 mg extended-release every 12 hours, maximum 2 tablets/24 hours

Adults and age 12 and older. Sold behind the counter (ID, purchase limits). Drug Facts: ask a doctor first with heart disease, hypertension, thyroid disease, diabetes or prostate-related urinary trouble; no MAOI within 2 weeks; stop for nervousness, dizziness or sleeplessness.

Cough: dextromethorphan (Delsym extended-release suspension, 30 mg/5 mL)

10 mL (60 mg) every 12 hours, maximum 20 mL (120 mg)/24 hours

Measure with the supplied cup. No MAOI within 2 weeks. Ask a doctor first for chronic cough (smoking, asthma, emphysema) or cough with heavy phlegm; stop if cough lasts over 7 days, returns, or comes with fever, rash or persistent headache.

Mucus: guaifenesin (Mucinex 600 mg extended-release)

1–2 tablets (600–1,200 mg) every 12 hours, maximum 4 tablets (2,400 mg)/24 hours

Swallow whole with a full glass of water, with or without food. Not for children under 12. Same 7-day stop rule as above.

  • FDA proposed on Nov 7, 2024 to remove oral phenylephrine from the OTC monograph because it does not relieve congestion; no final order was located as of October 2026, so products may remain on shelves.

Before prescribing

Check blood pressure, coronary disease or arrhythmia, thyroid disease, prostate-related urinary retention, diabetes, MAOI use, and duplicate acetaminophen or antihistamine ingredients in combination products. Confirm the product has no oral phenylephrine.

Side effects and return precautions

Palpitations, rising blood pressure, insomnia, tremor or urinary retention with pseudoephedrine; sedation from antihistamine combinations. Fever, rash, dyspnea or cough beyond 7 days suggests another diagnosis.

Follow-up

Reassess if not improving by 7 days or if fever develops; consider sinusitis, pneumonia, asthma or COPD with persistent cough or wheeze. Stop when symptoms resolve; avoid ongoing use.

Sources

Checked October 15, 2026.

Oxybutynin ER (Ditropan XL)Overactive bladder

What to say

For bladder urgency and leakage, we’re trying oxybutynin extended release 5 milligrams once daily. Swallow it whole with water. Don’t crush or split it. Keep using the bladder-training plan too. You may notice dry mouth, constipation or blurred vision. Tell us if these interfere with daily life, and avoid driving if you feel drowsy or your vision is blurred.

This medicine can make it harder to sweat, so avoid overheating. If you can’t pass urine, go to the emergency department. Stop and call the same day for new confusion or hallucinations. Severe confusion means go to the emergency department. Stop and get immediate eye care or go to the emergency department for sudden eye pain with blurred vision. We’ll review your bladder diary and side effects in four weeks before deciding whether to increase the dose. Let’s know about other sleep, allergy or bladder medicines, because their effects can add up.

Clinical reference

Dose options

Adult extended-release start

5 or 10 mg orally once daily

The wording above starts at 5 mg. Swallow whole; an empty tablet shell can appear in stool.

Titration

Increase by 5 mg at approximately weekly intervals if needed and tolerated

Maximum 30 mg daily in adults; do not titrate through retention, troublesome cognitive effects or severe constipation.

Older adults or renal/hepatic impairment

Choose cautiously; no validated renal/hepatic adjustment is supplied by the label

Consider anticholinergic burden and alternatives rather than interpreting lack of an adjustment as proof of safety.

Before prescribing

Exclude UTI and evaluate hematuria; assess emptying/PVR when retention is plausible. Contraindications include urinary/gastric retention and uncontrolled narrow-angle glaucoma. Review constipation, cognition and other anticholinergics. Discuss the association between chronic antimuscarinic exposure and dementia, especially in older adults; consider a beta-3 agonist.

Side effects and return precautions

Dry mouth, constipation, dizziness and blurred vision are common. Urinary retention, acute glaucoma symptoms, severe confusion and heat illness require urgent assessment. Cognitive adverse effects can occur after initiation or a dose increase.

Follow-up

Review urgency/leakage diary and side effects after about four weeks, sooner for retention or cognitive symptoms. Continue only with meaningful benefit and acceptable burden.

Sources

Checked September 20, 2026.

Oxycodone IR (Roxicodone)Short-term severe acute pain

What to say

For the severe pain from [injury or procedure], we’re adding a small supply of oxycodone, an opioid, because other treatments aren’t enough. Take one 5-milligram tablet only when needed for severe pain, no more often than every 4 hours, and keep taking [acetaminophen or ibuprofen] on schedule. A few days is often enough; as the pain eases, space doses out and stop. Start a laxative now to prevent constipation.

It can cause sleepiness, nausea, itching and constipation. Don’t drive, drink alcohol or combine it with sleeping pills, benzodiazepines or other sedatives. Opioids can cause addiction and fatal overdose. Keep naloxone at home and show someone how to use it: if you’re hard to wake or breathing slowly, they should give it and call 911. Keep tablets locked up, never share them, and take leftovers to a pharmacy drop-off kiosk. Call us if pain isn’t improving.

Clinical reference

Dose options

Opioid-naïve adult, acute pain

5 mg orally every 4–6 hours as needed (label range 5–15 mg); quantity only for the expected days of severe pain

CDC 2022: immediate-release opioid at the lowest effective dose, as needed rather than scheduled; a few days or less is often enough for many nonsurgical causes. Pair with scheduled nonopioid analgesia.

Older adults; hepatic or renal impairment

Start at the low end and titrate cautiously; label advises a lower-than-usual start in hepatic impairment

Oxycodone is substantially renally excreted; watch sedation and breathing. Taper rather than stop if taken around the clock for more than a few days.

  • Schedule II: no refills. California requires a CURES check before the first prescription unless an exemption applies.

Before prescribing

Check CURES (California: before the first controlled-substance prescription and every 6 months if continued). Review opioid tolerance, benzodiazepines/sedatives, alcohol, substance use history, sleep apnea/lung disease, CYP3A4 inhibitors/inducers and pregnancy. Offer naloxone.

Side effects and return precautions

Sedation, nausea, constipation, pruritus; respiratory depression, especially with sedatives, lung disease or older age; misuse and addiction; hyperalgesia, adrenal insufficiency, severe hypotension. Withdrawal after regular use.

Follow-up

Reassess before any further prescription; no automatic renewals. Persistent pain beyond the expected course needs re-evaluation, not escalation. Confirm the disposal plan and naloxone access.

Sources

Checked October 15, 2026.

Pantoprazole (Protonix)Erosive esophagitis

What to say

To heal the reflux-related irritation in your food pipe, take pantoprazole 40 milligrams once a day for eight weeks. This is the delayed-release tablet: swallow it whole without crushing, chewing or splitting it. We’ll use a consistent morning schedule. The tablet may be taken with or without food.

It lowers acid but isn’t an instant antacid. Headache, nausea or loose stools can happen. Contact us if these persist, and call the same day for ongoing watery diarrhea, much less urine, trouble swallowing or repeated vomiting. Vomiting blood or black stools means go to the emergency department. New chest pressure with sweating or breathlessness means call 911. We’ll review the response and decide whether you need continuing treatment after this course. Tell us before an H. pylori stool or breath test, because this medicine can affect the result.

Clinical reference

Dose options

Erosive esophagitis associated with GERD

40 mg orally once daily for up to 8 weeks

The wording above uses the tablet for diagnosed reflux esophagitis; an additional 8 weeks may be considered if unhealed.

Maintenance of healed erosive esophagitis

40 mg once daily

Reassess indication and lowest effective long-term regimen; the initial eight-week endpoint is not appropriate for every severity.

Formulation

Delayed-release tablets: swallow whole, with or without food

Oral-suspension granules have different preparation and meal instructions; do not transpose tablet directions.

Before prescribing

Review alarm features, prior endoscopy/severity, interactions and H. pylori testing. Rilpivirine-containing products are contraindicated with PPIs. Long-term need depends on indication.

Side effects and return precautions

Headache/GI effects; assess severe diarrhea, renal symptoms or hypersensitivity. Bleeding or possible cardiac symptoms need urgent evaluation.

Follow-up

Review during or at the eight-week course end; persistent symptoms or severe esophagitis may require further evaluation/maintenance rather than automatic stopping. Agree on rebound-symptom management when deprescribing.

Sources

Checked September 20, 2026.

Paroxetine (Paxil)Depression and anxiety

What to say

Take paroxetine once each morning, with or without food. For depression or social anxiety, start 20 milligrams. For panic or generalized anxiety, start 10 milligrams for the first week, then 20 milligrams. Take it every day, not just when you feel anxious. Benefits build over several weeks, and we’ll adjust the dose slowly if needed.

Nausea, sweating, sleepiness, dry mouth, constipation and sexual side effects can happen; tell us if they’re a problem. Don’t stop suddenly: paroxetine is more likely than many antidepressants to cause withdrawal symptoms like dizziness, irritability and flu-like feelings, so we’ll taper slowly. Call the same day for worsening thoughts of self-harm, marked agitation, or unusually high energy with very little sleep. If you might act on those thoughts, call 911. 988 can provide crisis support. Check with us before starting tamoxifen, other mood medicines, migraine triptans or blood thinners, or if you’re planning pregnancy.

Clinical reference

Dose options

Adult depression and anxiety disorders (Paxil tablets)

Each morning: depression or social anxiety 20 mg; panic disorder 10 mg; GAD 10 mg for 1 week, then 20 mg

If needed, increase by 10 mg/day at weekly intervals. Maximum: depression and GAD 50 mg/day; panic and social anxiety 60 mg/day (September 2026 label).

Older adults; severe renal or hepatic impairment

Start 10 mg daily; maximum 40 mg/day

Beers 2023: avoid in older adults (strongly anticholinergic, sedating, orthostatic hypotension); choose an alternative.

Other paroxetine products

Paxil CR (extended-release) and Brisdelle (7.5 mg at bedtime) have separate labels

Brisdelle treats menopausal vasomotor symptoms only, not psychiatric conditions. Don’t substitute products without converting the regimen.

Before prescribing

Screen suicidality, bipolar history, pregnancy plans (first-trimester cardiac malformation signal), age, narrow angles, bleeding and hyponatremia risk. Contraindicated: MAOIs within 14 days (including linezolid, IV methylene blue) and QT-prolonging CYP2D6 substrates such as pimozide or thioridazine.

Side effects and return precautions

Strong CYP2D6 inhibitor: raises TCAs, propranolol and other 2D6 substrates and may reduce tamoxifen efficacy (use another antidepressant). Serotonin syndrome, bleeding with antiplatelets or anticoagulants (monitor INR), angle closure, activation/mania.

Follow-up

Review within 2 weeks; 1 week at ages 18–25 or with increased suicide risk. Reassess response over several weeks. Taper gradually when stopping; label trials reduced by 10 mg/day weekly.

Sources

Checked October 15, 2026.

Penicillin G benzathine (Bicillin L-A)Syphilis

What to say

This long-acting penicillin shot cures syphilis. For infection under a year old, one dose of 2.4 million units, given as 1 or 2 injections in the buttocks, is enough. Older infection, or unknown timing, needs 3 weekly doses; keep each appointment, because a long gap means starting over. Because of a national shortage, we may use an imported version, Lentocilin, or doxycycline pills instead. Avoid sex until sores or rash have healed and partners are treated.

Within a day, some people get fever, chills, headache or aches. This is a treatment reaction, not an allergy; acetaminophen can help. Call 911 for hives with trouble breathing or swelling. Get same-day care for vision changes, hearing loss, ringing ears, severe headache or confusion; these can mean infection of the eyes, ears or nerves, which needs different treatment. We’ll test for HIV and other infections and recheck your syphilis blood test at 6 and 12 months, or longer.

Clinical reference

Dose options

Primary, secondary or early latent syphilis (nonpregnant adult)

2.4 million units IM once

Deep IM, upper outer buttock or ventrogluteal site. Boxed warning: never IV (cardiorespiratory arrest, death). Extra doses add no benefit.

Late latent or unknown-duration syphilis

2.4 million units IM weekly × 3 (7.2 million units total)

CDC: a 10–14-day interval might be acceptable in nonpregnant patients (7–9 days preferred); longer gaps restart the series. Label lists latent syphilis as 1 dose and neurosyphilis as 3 weekly doses; CDC treats neurosyphilis with IV aqueous penicillin G.

Shortage (projected through Q4 2027)

Prioritize for pregnancy and patients who can’t take doxycycline; Lentocilin (FDA temporary importation) is an alternative product

Bicillin C-R (benzathine plus procaine) is not acceptable for syphilis. Nonpregnant adults: doxycycline per CDC and SFDPH.

  • CDC (Apr 2026): recovery projected for Q4 2027; preserve benzathine penicillin G for pregnancy. SFDPH (Apr 30, 2026): doxycycline for nonpregnant adults; clinics should consider ordering Lentocilin.

Before prescribing

Stage the infection; ask about neurologic, ocular and otic symptoms (needs CSF/eye/ear evaluation and IV penicillin). Confirm penicillin allergy history and pregnancy status. Test HIV and other STIs; offer PrEP. Verify Bicillin L-A, not C-R.

Side effects and return precautions

Jarisch–Herxheimer reaction within 24 hours (fever, headache, myalgia); anaphylaxis; inadvertent intravascular injection (pallor, cyanosis, severe pain, Nicolau syndrome); SJS/DRESS.

Follow-up

Nontreponemal titers at 6 and 12 months (primary, secondary) or 6, 12 and 24 months (latent). Sustained fourfold rise or new signs: retreat, recheck HIV, consider CSF. Notify partners by stage.

Sources

Checked October 15, 2026.

Penicillin V potassium (Pen-Vee K, Veetids)Strep throat

What to say

Penicillin treats the bacteria causing your strep throat. Take 500 milligrams twice a day for ten days, even if you feel better sooner. You may take it with food if needed for an upset stomach.

Tell us about any previous penicillin reaction before starting. Stop and call for a new rash or severe diarrhea. Trouble breathing, faintness or tongue swelling means call 911. Stay home until you’re fever-free and have taken antibiotics for at least 24 hours. Contact us if you’re getting worse or aren’t improving after two to three days.

Clinical reference

Dose options

Adult GAS pharyngitis

500 mg orally twice daily for 10 days

Alternative adult schedule: 250 mg four times daily for 10 days.

  • Pen-Vee K and Veetids are historical U.S. brand names; prescribe the available generic product.

Before prescribing

Confirm GAS infection and assess beta-lactam allergy, swallowing ability, interactions and significant renal disease.

Side effects and return precautions

Nausea, diarrhea and allergic reactions. Drooling, inability to swallow fluids or marked neck swelling needs urgent assessment; breathing difficulty is an emergency.

Follow-up

Review persistent or worsening symptoms. Do not treat a viral sore throat with antibiotics.

Sources

Checked September 23, 2026.

Peppermint oil capsules (IBgard)IBS symptoms

What to say

Peppermint oil can ease IBS belly pain and bloating by relaxing the bowel muscle. Use a coated or slow-release capsule such as IBgard; tea or plain oil isn’t the same. Take 2 capsules with water 30 to 90 minutes before a meal, up to 3 times a day, daily or when symptoms flare. A missed pre-meal dose can be taken with the meal. Don’t take more than 8 capsules a day. Try it for about 4 weeks, then tell us whether it’s helping.

Heartburn or nausea can happen; coated capsules make heartburn less likely. Supplements aren’t checked like prescriptions, so choose a well-tested product. Ask us first if you’re pregnant. Call 911 for face or throat swelling or trouble breathing. Call us for rectal bleeding, weight loss, fever, diarrhea that wakes you at night or worsening symptoms, because those aren’t typical of IBS.

Clinical reference

Dose options

IBgard (sustained-release peppermint oil)

2 capsules 30–90 minutes before meals, 1–3 times daily, daily or as needed; maximum 8 capsules/day

Manufacturer directions; clinically studied at 6 capsules/day. A missed pre-meal dose may be taken with or after the meal.

Other enteric-coated products

Follow the product label; trials used continuous enteric-coated dosing for 2–12 weeks

ACG 2021 suggests peppermint for global IBS symptoms (conditional, low quality). Dose, coating and quality vary between supplements.

  • Not an FDA-approved drug: sold over the counter, and peppermint oil products vary in dose, coating and quality.

Before prescribing

Confirm IBS without alarm features (bleeding, weight loss, anemia, nocturnal symptoms, family history of colorectal cancer, IBD or celiac disease). Ask about reflux, pregnancy and other supplements.

Side effects and return precautions

Heartburn/reflux, nausea, abdominal pain, dry mouth; rare allergic reactions. Alarm features or progressive symptoms need evaluation rather than more supplements.

Follow-up

Reassess global symptoms and pain after about 4 weeks; continue if helpful, stop if not. Combine with diet changes and other evidence-based IBS treatments.

Sources

Checked October 15, 2026.

Permethrin 5% cream (Elimite)Scabies

What to say

Apply permethrin 5% cream to all the skin from your neck down, not just the itchy spots. Include skin folds, between fingers and toes, and under the nails. Keep it out of your eyes, mouth and vagina. Leave it on for eight to fourteen hours, then wash it off. For your plan, repeat this in one week on [date].

Household members and close contacts should be treated at the same time. Wash recently used bedding, towels and clothes in hot water and dry on high heat. Seal things you can’t wash in a bag for at least seventy-two hours, up to a week. Avoid skin-to-skin contact until treatment is completed.

Itching can continue for several weeks after the mites are gone. Don’t keep applying extra cream for itching alone. Contact us for new burrows or bumps, itching beyond two to four weeks, or skin sores, spreading redness or fever.

Clinical reference

Dose options

Adult classic scabies

5% cream from neck down; wash off after 8–14 hours

One treatment can work; the wording above includes a second application about a week later.

Other presentations

Confirm age, distribution and diagnosis before choosing application instructions

Infants/young children may need head and neck treatment. Crusted scabies requires a different, often combined regimen. 1% lice lotion is not this prescription.

Before prescribing

Review permethrin/pyrethrin allergy, pregnancy, skin infection, immune status and contact exposure. Arrange enough cream, contact treatment and laundering. Approved for scabies from age 2 months.

Side effects and return precautions

Transient burning, stinging or itching. Persistent itch alone does not prove treatment failure; assess reinfestation, missed areas and secondary infection.

Follow-up

Document repeat-treatment date. Reassess new lesions or persistent symptoms after 2–4 weeks rather than automatically repeating indefinitely.

Sources

Checked September 24, 2026.

Phenazopyridine (Pyridium, AZO)Bladder-infection pain

What to say

Phenazopyridine numbs the bladder lining to ease burning, urgency and frequency while your antibiotic starts working. It doesn’t treat the infection, so keep taking the antibiotic. Take 200 milligrams three times a day after meals for no more than two days. If you buy it over the counter, that’s two tablets three times a day.

Your urine will turn orange-red, and it can stain clothes and soft contact lenses. It can also affect urine tests. Don’t use it if you have kidney disease or G6PD deficiency, and ask first if you have liver disease or are pregnant. Stop it and call the same day for yellow skin or eyes, much less urine than usual, or symptoms lasting beyond two days. Fever, back pain or vomiting can mean a kidney infection, so call the same day. Blue or gray lips or skin means go to the emergency department; severe trouble breathing means call 911.

Clinical reference

Dose options

Prescription tablets (100 or 200 mg)

200 mg orally three times daily after meals, for up to 2 days with an antibiotic

Label: don’t exceed 2 days alongside antibacterial treatment of UTI, and stop once symptoms are controlled. Symptomatic relief only.

Over-the-counter tablets (95–99.5 mg)

2 tablets three times daily with or after meals; maximum 2 days (12 tablets)

OTC labels: don’t use with G6PD deficiency unless a physician approves; ask a doctor first with kidney or liver disease or pregnancy.

Before prescribing

Use only while the cause is diagnosed and treated; collect urinalysis or culture before the first dose, because the dye interferes with color-based tests. Contraindicated in renal insufficiency (consider age-related decline). Avoid with G6PD deficiency; caution in liver disease and pregnancy.

Side effects and return precautions

Headache, GI upset, rash, pruritus. Yellow skin or sclera suggests accumulation: stop. Methemoglobinemia, hemolytic anemia and renal or hepatic toxicity occur mainly with overdose or renal impairment; G6PD deficiency predisposes to hemolysis.

Follow-up

Stop after 2 days, or sooner when symptoms ease. Persistent or worsening symptoms, fever or flank pain need reassessment and culture review rather than more analgesic.

Sources

Checked October 15, 2026.

Phentermine (Adipex-P, Lomaira)Weight management

What to say

For weight loss alongside eating and activity changes, start phentermine with half of a 37.5 milligram tablet each morning, before breakfast or 1–2 hours after. Later doses can keep you awake. It’s approved for short-term use, a few weeks; using it longer is off-label, and we’d continue only if it’s helping and your blood pressure and heart rate stay safe. It’s a controlled medicine: keep it locked up and never share it. If it stops working, don’t take more.

Dry mouth, trouble sleeping, jitteriness, constipation and a faster heartbeat are common, and blood pressure can rise. Avoid alcohol and other weight-loss products, including supplements, and never take it within 14 days of an MAOI, a type of antidepressant. Stop it and call us the same day for new breathlessness with activity, fainting or ankle swelling. Chest pain, a racing heartbeat with dizziness, or sudden weakness or trouble speaking means call 911. Stop it and call us if you become pregnant.

Clinical reference

Dose options

Phentermine 37.5 mg tablets or capsules (Adipex-P, generic)

18.75–37.5 mg once each morning, before breakfast or 1–2 hours after; 18.75 mg twice daily is an alternative

Use the lowest effective dose; maximum 37.5 mg/day. Labeled for short-term use (a few weeks); longer use is off-label. If tolerance develops, stop rather than increase.

Lomaira 8 mg tablets

8 mg up to 3 times daily, 30 minutes before meals

Scored; a half tablet may be enough. Avoid late-evening doses because of insomnia.

Kidney function

eGFR 15–29: maximum 15 mg daily; avoid at eGFR <15 or on dialysis

Renally excreted; start low in older adults.

  • AGA 2022 suggests phentermine with lifestyle changes for adults with obesity, or overweight with weight-related complications.

Before prescribing

Contraindicated with CVD history (CAD, stroke, arrhythmia, HF, uncontrolled hypertension), hyperthyroidism, glaucoma, agitation, drug-misuse history, MAOI within 14 days, pregnancy or breastfeeding. Check BP, HR, eGFR. Label: avoid combining with other weight-loss drugs or SSRIs.

Side effects and return precautions

BP and HR rise, palpitations, insomnia, anxiety, dry mouth, constipation, misuse; lows on insulin or sulfonylureas. Rare pulmonary hypertension or valve disease: new dyspnea, angina, syncope or edema means stop and evaluate.

Follow-up

Recheck weight, BP and HR within the first month, then regularly; stop if response is inadequate by 12 weeks. Document the rationale for longer off-label use. California: check CURES first and at least every 6 months.

Sources

Checked October 15, 2026.

Phentermine/topiramate ER (Qsymia)Weight management

What to say

For weight loss alongside eating and activity changes, take Qsymia 3.75/23 milligrams each morning for 14 days, then 7.5/46 milligrams; evening doses can disturb sleep. If you’ve lost less than 3% of your weight at 12 weeks, we may step up to the top dose; if that hasn’t brought 5% after 12 more weeks, we’ll taper off. Never stop the top dose suddenly, which can cause a seizure. For a missed dose, just take the next morning’s dose.

It can cause serious birth defects. If you could become pregnant, you need a negative pregnancy test before starting and monthly, plus reliable birth control. Tingling, dry mouth, constipation, poor sleep and slowed thinking or word-finding are common; drink plenty of fluids to help prevent kidney stones. Sudden blurred vision or eye pain means stop it and go to the emergency department. Call us the same day for worsening mood or thoughts of self-harm; if you might act on them, call 911.

Clinical reference

Dose options

Adult weight management

3.75/23 mg each morning for 14 days, then 7.5/46 mg; at 12 weeks, if <3% weight loss, 11.25/69 mg for 14 days, then 15/92 mg

Stop if <5% loss after 12 weeks on 15/92 mg. Generic phentermine/topiramate ER follows the same schedule; all are dispensed only through REMS-certified pharmacies.

Stopping 15/92 mg

Take every other day for at least 1 week, then stop

Abrupt topiramate withdrawal can provoke seizures, even without epilepsy.

Kidney and liver

CrCl <50 mL/min or Child-Pugh 7–9: maximum 7.5/46 mg daily

Avoid in ESRD on dialysis and in Child-Pugh 10–15. Calculate CrCl by Cockcroft-Gault with actual body weight.

  • Labeled for long-term use, unlike phentermine alone. AGA 2022 suggests it with lifestyle changes for adults with obesity, or overweight with weight-related complications. Avoid other carbonic anhydrase inhibitors such as acetazolamide or zonisamide.

Before prescribing

Contraindicated in pregnancy, glaucoma, hyperthyroidism and with an MAOI within 14 days. Pregnancy test before starting and monthly, with effective contraception (REMS); COC spotting isn’t a reason to stop the COC. Baseline bicarbonate, creatinine, potassium; glucose if on diabetes drugs.

Side effects and return precautions

Paresthesias, dysgeusia, insomnia, constipation, cognitive or word-finding problems, depression or suicidality; acute myopia with angle-closure glaucoma; metabolic acidosis, hypokalemia, creatinine rise, nephrolithiasis; decreased sweating; heart-rate rise; DRESS or SJS/TEN.

Follow-up

Check weight, BP, HR and mood at visits; repeat chemistry periodically. Escalate if <3% loss at 12 weeks on 7.5/46 mg; taper off if <5% at 12 weeks on 15/92 mg. California: CURES first and every 6 months.

Sources

Checked October 15, 2026.

Pilocarpine tablets (Salagen)Dry mouth in Sjögren’s disease or after radiation

What to say

Pilocarpine helps your glands make more saliva to ease dry mouth. For Sjögren’s disease, take one 5-milligram tablet 4 times a day; after head and neck radiation, the usual start is 5 milligrams 3 times a day. Give it several weeks; we’ll check in on [date]. Keep sipping water, use sugar-free gum or lozenges, and use fluoride as your dentist advises, since dry mouth raises cavity risk.

Sweating is the most common side effect, so drink extra water, especially in hot weather. Flushing, chills, nausea and needing to urinate more often can also happen. It can blur vision at night, so take care driving in the dark. Tell us if you have asthma, COPD, glaucoma, heart disease, gallstones or kidney stones, or memory or mood problems. Stop it and call us the same day for wheezing, a slow or irregular heartbeat, or severe belly or side pain. Call 911 for severe trouble breathing, chest pain or fainting.

Clinical reference

Dose options

Sjögren’s disease

5 mg orally four times daily

Efficacy shown by 6 weeks; trials ran 12 weeks. Sweating (40% vs 7% on placebo) was the most common reason for stopping. Older adults had about twice the urinary frequency and diarrhea and 3 times the dizziness. A high-fat meal slows absorption.

After head and neck radiation

Start 5 mg three times daily; titrate to 15–30 mg/day, no more than 10 mg per dose

At least 12 weeks of uninterrupted therapy may be needed to judge response. Side effects rise with dose; maintain the lowest effective dose.

Liver and kidney function

Moderate hepatic impairment: start 5 mg twice daily; severe (Child-Pugh 10–15): not recommended

No dose change for mild hepatic impairment; pharmacokinetics were unchanged in renal impairment (CrCl about 25 mL/min).

  • Tablets only: pilocarpine eye drops (for example Vuity, for presbyopia) are a different product.

Before prescribing

Contraindicated: uncontrolled asthma, acute iritis, narrow-angle glaucoma, hypersensitivity. Use caution with significant heart disease, controlled asthma or COPD, gallstones or kidney stones, cognitive or psychiatric disorders, beta-blockers and pregnancy. Benefit needs some remaining gland function.

Side effects and return precautions

Sweating, urinary frequency, flushing, chills, nausea, rhinitis; dizziness in older adults; night-vision blurring. Cholinergic excess: lacrimation, GI cramping, bronchospasm, bradycardia or AV block, hypotension, confusion, tremor. Biliary or renal colic with stones.

Follow-up

Reassess by 6–12 weeks in Sjögren’s, or after at least 12 weeks after radiation; stop if there’s no clear benefit. Continue sugar-free saliva stimulants, topical fluoride and regular dental visits; cevimeline is an alternative.

Sources

Checked October 20, 2026.

Pioglitazone (Actos)Type 2 diabetes

What to say

For your type 2 diabetes, we’re adding pioglitazone 15 milligrams once a day, with or without food. It helps your body use its own insulin better and is one of the lower-cost options. It works slowly, so we’ll judge it by your A1c, the 3-month blood sugar test, and may raise the dose. Alone it rarely causes lows, but it can with insulin or glipizide-type pills. If you miss a dose, don’t double the next one.

Weight gain and ankle swelling are common. Call us the same day for fast weight gain, new swelling, or shortness of breath, especially lying down; severe trouble breathing means call 911. Stop it and call for yellow skin or eyes, dark urine, or unexplained nausea, belly pain or tiredness. Tell us about blood in your urine, vision changes or a broken bone. If you’re premenopausal, it can make pregnancy more likely, so let’s discuss birth control; pregnancy needs a different plan.

Clinical reference

Dose options

Type 2 diabetes

15 or 30 mg orally once daily; increase by 15 mg based on A1c to a maximum of 45 mg daily

Start 15 mg with NYHA class I–II heart failure. No renal or hepatic dose adjustment. Watch weight and edema after starting and after each increase.

Interactions and combinations

Maximum 15 mg daily with gemfibrozil or another strong CYP2C8 inhibitor

Rifampin lowers exposure. Edema and heart failure are more common with insulin; if lows occur on insulin, the label advises cutting insulin 10–25%.

  • ADA 2026 and AASLD 2023 support pioglitazone for glycemic management in type 2 diabetes with MASH (improves steatohepatitis; no proven antifibrotic benefit). It isn’t FDA-approved for MASH.

Before prescribing

Don’t start in NYHA class III–IV heart failure; avoid in symptomatic HF. Check baseline LFTs, edema, CKD (ADA: generally avoid, fluid retention), fracture risk, active or prior bladder cancer, macular edema, insulin use, gemfibrozil and contraception.

Side effects and return precautions

Dose-related edema and weight gain; HF (boxed warning), more with insulin; hepatotoxicity (interrupt if ALT >3× ULN); hematuria (bladder cancer); distal fractures in women; macular edema; lows with insulin or sulfonylureas.

Follow-up

A1c about 3 months after each change; weight and edema at each visit and after increases. Prompt LFTs for liver symptoms. Keep regular eye exams. Reduce insulin or sulfonylurea if lows occur.

Sources

Checked October 15, 2026.

Pivmecillinam (Pivya)Uncomplicated cystitis

What to say

For this bladder infection, take pivmecillinam (Pivya) 185 milligrams, 1 tablet 3 times a day for [3–7] days, with or without food. It’s a penicillin-type antibiotic long used in Europe. If you miss a dose, take it when you remember, but don’t double up. Some pharmacies don’t stock it, so tell us about delays or cost.

Nausea and diarrhea are the most common side effects, and a vaginal yeast infection can follow. Tell us if you take valproate or methotrexate. Stop it and call the same day for a new rash. A blistering rash or mouth sores means go to the emergency department. Trouble breathing or lip or tongue swelling means call 911. Call the same day if you aren’t improving in 2 days, or for fever, side or back pain, or vomiting. Severe watery or bloody diarrhea needs a same-day call, even weeks later.

Clinical reference

Dose options

Uncomplicated cystitis, women 18 and older

185 mg orally three times daily for 3–7 days as clinically indicated

US label dose (185 mg pivmecillinam = 200 mg HCl salt). EAU’s 400 mg three times daily for 3–5 days refers to European tablets; don’t transpose it.

Organ function and course length

No renal or hepatic dose adjustment in the label

Label: consider alternatives when carnitine depletion is more likely (significant renal impairment, low muscle mass); not for prolonged courses. Don’t use for pyelonephritis (EAU).

Before prescribing

Confirm uncomplicated cystitis in a nonpregnant woman. Contraindicated after serious β-lactam hypersensitivity, with inherited carnitine-deficiency disorders, or porphyria. Avoid valproate and other pivalate drugs; methotrexate clearance may fall. Check pharmacy availability.

Side effects and return precautions

Nausea, diarrhea, vulvovaginal candidiasis, headache. Anaphylaxis or SCAR (SJS/TEN, DRESS, AGEP) requires stopping and emergency care. Watch for C. difficile; esophagitis and hepatic abnormalities reported postmarketing.

Follow-up

Reassess no improvement at 48 hours and act on culture. No test-of-cure after resolution. Carnitine effects of repeated short courses are unknown; plan alternatives for frequent recurrence.

Sources

Checked October 15, 2026.

Polyethylene glycol 3350 (MiraLAX)Constipation

What to say

Try polyethylene glycol powder, 17 grams once a day, mixed completely into four to eight ounces of a drink. Use the marked cap or packet so the amount is consistent. It holds water in the stool to make it easier to pass.

It can take one to three days, so don’t keep adding doses for an immediate result. Bloating or cramps can occur. If you develop watery stools, stop and contact us about adjusting the plan. If there’s no improvement after a few days, let’s know before increasing it. Severe belly pain or swelling with vomiting or inability to pass gas means go to the emergency department. We’ll agree on whether you need it beyond a week rather than leaving the duration open-ended.

Clinical reference

Dose options

Usual adult dose

17 g orally once daily, dissolved fully in 4–8 ounces of liquid

PEG 3350 without electrolytes; not colonoscopy preparation.

Duration / escalation

OTC use up to 7 days; longer clinician-directed use needs an explicit plan

Do not stack doses for immediate nonresponse; reassess symptoms and stool goal.

Before prescribing

Assess obstruction, impaction/alarm features, medication causes and renal/fluid context. Do not mix with starch-based thickeners used for dysphagia; arrange an alternative with the pharmacist.

Side effects and return precautions

Bloating, cramps, diarrhea. Obstruction symptoms need emergency care; bleeding, persistent pain or diarrhea needs clinical review.

Follow-up

Check response in several days; define dose adjustment, stop criteria and follow-up for persistent or recurrent constipation.

Sources

Checked September 20, 2026.

Polymyxin B/trimethoprim eye drops (Polytrim)Bacterial conjunctivitis

What to say

This looks like a bacterial infection of the eye’s surface, called conjunctivitis. Put 1 drop in the affected eye every 3 hours while you’re awake, up to 6 times a day, for 7 days. Wash your hands first, and keep the bottle tip from touching your eye. Mild infections often clear on their own, and the drops can help them clear sooner. If you wear contact lenses, leave them out until your eye has healed and the drops are finished.

Brief stinging or burning is common. Stop the drops and call us if redness, itching or swelling gets worse, which can mean an allergy. Call us if you aren’t better in 3–4 days. Get a same-day eye exam for eye pain, sensitivity to light, blurred vision that doesn’t clear with blinking, or heavy pus. Call 911 for trouble breathing or swelling of the face or throat. Wash your hands often, and don’t share towels, pillows or eye makeup.

Clinical reference

Dose options

Mild to moderate bacterial conjunctivitis

1 drop in the affected eye(s) every 3 hours while awake (maximum 6 doses/day) for 7 days

Label: 7–10 days; AAO PPP: a 5- to 7-day broad-spectrum topical course is usually effective, and no agent is superior. Contains benzalkonium chloride. Brand Polytrim is discontinued; prescribe the generic solution.

Gonococcal or chlamydial infection, keratitis, contact lens wear

Needs a different or closer plan

Gonococcal and chlamydial conjunctivitis need systemic treatment. Contact lens wearers need pseudomonal coverage (a topical fluoroquinolone is usual) and assessment for keratitis.

  • Mild bacterial conjunctivitis is usually self-limited; topical antibiotics speed early remission, and delayed prescribing gives similar symptom control with about half the antibiotic use.

Before prescribing

Confirm bacterial features (mucopurulent discharge, lids stuck shut) versus viral or allergic. Check acuity, pain, photophobia, corneal involvement, contact lens use, recent eye surgery and immune status; hyperacute purulence suggests gonococcus.

Side effects and return precautions

Stinging, burning, itching; hypersensitivity with lid edema or periocular rash; rare SJS/TEN or anaphylaxis. Pain, photophobia or reduced vision suggests keratitis or another serious eye disease.

Follow-up

Return if not improving in 3–4 days. Refer for vision loss, moderate–severe pain, severe purulent discharge, corneal involvement, nonresponse, recurrence, prior HSV eye disease or immunocompromise.

Sources

Checked October 15, 2026.

Potassium chloride ER (K-Tab)Prevention of diuretic-associated low potassium

What to say

I’m prescribing potassium chloride 20 milliequivalents once a day because your water pill keeps lowering your potassium. This replaces a mineral needed by your muscles and heart. Take the extended-release tablet with a meal and a full glass of water. Swallow it whole. Don’t crush or chew it. Tell us before starting if large tablets are hard to swallow.

Stomach upset can happen. Stop it and go to the emergency department for severe belly pain, persistent vomiting, or bloody or black, sticky stools. Call 911 for fainting or a racing heartbeat with chest pain. Don’t add potassium supplements or potassium-containing salt substitutes. We’ll recheck potassium and kidney function within a week. Call if your water pill is stopped, your other heart medicines change, or you can’t keep fluids down. The potassium dose may need to change too.

Clinical reference

Dose options

Prevention

20 mEq orally once daily

For ongoing diuretic-associated loss when diet or diuretic adjustment is insufficient; personalize to laboratory results.

Replacement range, P20 ER tablet

40–100 mEq/day in divided doses; no more than 20 mEq per dose

The cited product has a 20-mEq single-dose limit. Other formulations have different instructions; prescribe in mEq, not salt milligrams.

Severe hypokalemia / kidney impairment

K <2.5 mEq/L: label directs IV replacement; urgent monitored assessment

Renal impairment requires a lower starting range and frequent potassium checks. Symptoms or ECG changes also warrant urgent evaluation.

Before prescribing

Check potassium, creatinine/eGFR, magnesium, losses and medications. The label contraindicates use with amiloride or triamterene. ACE inhibitors, ARBs, spironolactone and NSAIDs increase hyperkalemia risk. Consider liquid if dysphagia or delayed GI transit.

Side effects and return precautions

GI ulceration/bleeding and hyperkalemia are important hazards. Severe abdominal symptoms or GI bleeding require stopping and urgent assessment. Do not double a missed dose or self-adjust when diuretics change.

Follow-up

Set an exact potassium/creatinine recheck based on deficit and renal risk: within a week for stable prevention, earlier for active or high-risk replacement. Recheck after dose or interacting-medication changes.

Sources

Checked September 20, 2026.

Potassium citrate (Urocit-K)Kidney stone prevention

What to say

To help prevent new kidney stones, take potassium citrate [dose] milliequivalents twice a day with meals. Swallow each tablet whole; don’t crush, chew or suck it. It makes your urine less acidic and raises citrate, which helps stop stones from forming. Keep drinking enough water to make at least 2.5 liters of urine a day, and limit salt.

Stomach upset or loose stools can happen. Call the same day for trouble swallowing, a tablet that feels stuck, severe vomiting, belly pain, or black stools. Potassium that gets too high can cause weakness or an irregular heartbeat. Call 911 for fainting or a very fast or slow heartbeat. Avoid salt substitutes and potassium supplements, and check with us before starting blood pressure pills, water pills or anti-inflammatory pain relievers. We’ll check blood tests and repeat a 24-hour urine test.

Clinical reference

Dose options

Hypocitraturic calcium stones or uric acid stones (label)

Urinary citrate >150 mg/day: 15 mEq twice daily; <150 mg/day: 30 mEq twice daily; with meals

Or divide three times daily. Titrate to 24-hour urine citrate (>320 mg/day) and pH 6.0–7.0; doses >100 mEq/day not studied.

AUA 2026

Alkali suggested for adults with recurrent calcium oxalate stones regardless of urinary citrate; urinary alkalinization prioritized for uric acid stones

Normocitraturic use goes beyond the labeled indications. Urine volume goal ≥2.5 L/day (label: ≥2 L).

Contraindications (label)

Hyperkalemia or predisposition; GFR <0.7 mL/kg/min; delayed gastric emptying or GI obstruction; peptic ulcer; active UTI

Avoid potassium-sparing diuretics; caution with ACEi/ARB, spironolactone, eplerenone, NSAIDs and anticholinergics.

Before prescribing

Base on stone type and 24-hour urine. Check potassium, creatinine/eGFR, GI motility problems, peptic ulcer and active UTI. Review RAAS blockers, potassium-sparing diuretics, NSAIDs, anticholinergics and potassium supplements.

Side effects and return precautions

GI upset; GI ulceration or bleeding (stop for severe vomiting, abdominal pain or melena). Hyperkalemia is often asymptomatic and can cause arrhythmia or arrest, especially with CKD or RAAS blockers.

Follow-up

Label: electrolytes, creatinine and CBC every 4 months, more often with cardiac or renal disease; periodic ECG. Repeat 24-hour urine citrate/pH to titrate; image per stone activity.

Sources

Checked October 15, 2026.

Pravastatin (Pravachol)Cholesterol lowering

What to say

Pravastatin lowers LDL, the “bad” cholesterol, to reduce your chance of a heart attack or stroke. Take 40 milligrams once a day, at any time of day, with or without food. It has fewer drug interactions than some other statins. We’ll recheck your cholesterol in 4–12 weeks and adjust the plan if needed. This is usually a long-term medicine.

Most people have no side effects. Muscle aches are common and usually aren’t caused by the statin, so talk with us before stopping it. Call the same day for unexplained muscle pain or weakness, especially with fever or dark urine, or for yellow skin or eyes. Before starting gemfibrozil, cyclosporine, or antibiotics like clarithromycin, check with us. If you take cholestyramine, take pravastatin 1 hour before or 4 hours after it. If you become pregnant, stop it and contact us; don’t breastfeed while taking it.

Clinical reference

Dose options

Usual adult dose

40 mg orally once daily, any time of day; range 10–80 mg

Label starting dose is 40–80 mg. 2026 ACC/AHA: 40–80 mg is moderate intensity and 10–20 mg low intensity; if ≥50% LDL-C lowering is needed, use high-intensity atorvastatin or rosuvastatin instead.

Renal impairment and interacting drugs

Severe renal impairment: start 10 mg, max 40 mg. Cyclosporine: start 10 mg, max 20 mg. Clarithromycin or erythromycin: max 40 mg

No change for mild–moderate renal impairment. Avoid gemfibrozil. Give pravastatin ≥1 hour before or 4 hours after a bile acid sequestrant.

Before prescribing

Contraindicated in acute liver failure or decompensated cirrhosis. Review gemfibrozil, cyclosporine, macrolides, other lipid drugs, untreated hypothyroidism, renal function, alcohol use, pregnancy plans and breastfeeding. Baseline lipids; consider baseline ALT.

Side effects and return precautions

Myalgia is common and often not statin-related; check CK for weakness or severe pain. Stop for rhabdomyolysis, suspected immune-mediated necrotizing myopathy or hepatic injury. Small A1C/glucose rise.

Follow-up

Lipid panel 4–12 weeks after starting or changing dose, then every 6–12 months. If LDL-C remains above goal, switch to a high-intensity statin or add a nonstatin per the 2026 guideline.

Sources

Checked October 15, 2026.

Prazosin (Minipress)PTSD nightmares, off-label

What to say

For trauma-related nightmares, we’re trying prazosin off-label. It’s an older blood pressure medicine that blocks some adrenaline-like signals linked to nightmares. Start 1 milligram at bedtime, taking it once you’re in bed. We’ll raise the dose slowly until nightmares ease or side effects limit it. Trauma-focused therapy remains an important part of treatment.

The main risk is dizziness or fainting when you stand, especially after the first dose or an increase. Sit on the edge of the bed before standing up slowly, and avoid driving or risky tasks for 24 hours after starting or increasing it. Headache, drowsiness, low energy and a pounding heartbeat can happen. If you miss several days, ask us how to restart. Check with us before taking erectile dysfunction or new blood pressure medicines. An erection lasting over 4 hours needs emergency care. Call 911 for fainting with injury, chest pain or trouble breathing.

Clinical reference

Dose options

PTSD-associated nightmares (off-label)

1 mg at bedtime; titrate gradually to response (VA/DoD range 3–20 mg at bedtime)

VA/DoD 2023: weak recommendation for nightmares, but suggests against prazosin for overall PTSD symptoms. AASM 2018: may be used. A large 2018 VA trial found no benefit over placebo, so evidence is mixed.

Hypotension risk and interactions

Label (hypertension): when adding a diuretic or other antihypertensive, reduce to 1–2 mg three times daily and re-titrate; start PDE-5 inhibitors at the lowest dose

Syncope usually occurs 30–90 minutes after the initial dose (VA/DoD). Label hypertension dosing is divided 2–3 times daily.

  • Off-label: FDA-labeled only for hypertension.

Before prescribing

Confirm PTSD-related nightmares and offer trauma-focused psychotherapy. Check BP and orthostasis, falls risk, antihypertensives or diuretics, PDE-5 inhibitors, planned cataract surgery (IFIS) and pregnancy.

Side effects and return precautions

Orthostatic hypotension and syncope with the first dose, titration or added antihypertensives; dizziness, headache, drowsiness, lack of energy, palpitations, nausea; priapism (emergency).

Follow-up

Review nightmares, sleep and orthostatic BP after each increase. If no benefit at a tolerated dose, taper off. After a lapse of several days, restart low and re-titrate.

Sources

Checked October 15, 2026.

Prednisone (Deltasone)Acute gout flare

What to say

We’re using a short prednisone course for this gout flare after reviewing which treatments are suitable for you. Take [prescribed dose] each morning with food for [number of days], following the written stop or taper plan. It reduces the inflammation from this attack. It doesn’t lower uric acid or replace long-term gout prevention.

It can affect sleep, mood and blood sugar. Don’t add ibuprofen or naproxen unless we specifically agree. Call if the joint isn’t improving within two to three days. Fever, feeling very unwell or rapidly worsening joint pain needs same-day assessment because an infected joint can resemble gout. Keep taking prescribed urate-lowering treatment unless we tell you otherwise.

Clinical reference

Dose options

Oral glucocorticoid course

Prednisone, commonly at least 0.5 mg/kg/day for 5–10 days

ACR regimen: stop after the short course, or use a shorter full-dose phase followed by an individualized taper. Write the exact dose and duration; account for prior steroid exposure.

Before prescribing

Confirm gout and exclude septic arthritis when indicated. Choose among NSAID, colchicine and glucocorticoid based on comorbidities, interactions and preference. Review diabetes, psychiatric/infection risks and prior steroid exposure.

Side effects and return precautions

Insomnia, appetite, mood and glucose changes; infection and GI risks. Severe mood disturbance, psychosis or inability to stay safe requires urgent/emergency assessment. Avoid unsupervised NSAID combinations.

Follow-up

Review response within 2–3 days if not improving. Reassess diagnosis for fever/systemic illness, and address long-term urate control after the flare.

Sources

Checked September 23, 2026.

Prednisone (Deltasone)Asthma exacerbation

What to say

For this asthma flare, take prednisone 40 milligrams each morning with food for five days. This short course reduces airway inflammation. Keep following the inhaler plan we have written down. Prednisone doesn’t replace your rescue medicine. After the fifth day, stop. You don’t need to reduce this particular course gradually.

You may feel wired, have trouble sleeping, feel hungrier or notice mood changes. Blood sugar can rise. If you have diabetes, we’ll write down how often to check and when to call. Call the same day for marked mood changes or other troublesome effects. Immediate danger of self-harm or dangerous confusion means call 911. If breathing is getting worse, you can’t speak comfortably or the rescue medicine isn’t helping, call 911. We’ll reassess the flare within two to seven days.

Clinical reference

Dose options

Adult asthma exacerbation

40–50 mg orally each morning for 5–7 days

Use after assessment; the wording above uses 40 mg for 5 days.

Stopping this short course

A course <2 weeks usually needs no taper

Chronic/repeated exposure or adrenal-suppression concerns need individualized instructions.

Other diseases

No universal prednisone starting dose or maximum

Do not apply an asthma burst to inflammatory, endocrine or other conditions.

Before prescribing

Confirm exacerbation severity, inhaler access/action plan, diabetes, psychiatric history, infection risks and recent/chronic steroid exposure. An unstable exacerbation requires immediate care, not merely an outpatient prescription.

Side effects and return precautions

Insomnia, appetite, mood and glucose changes; infection and GI risks. Severe mood disturbance, psychosis or inability to stay safe requires urgent/emergency assessment. Avoid unsupervised NSAID combinations.

Follow-up

Follow up within 2–7 days after an exacerbation; reassess control, technique, controller therapy and repeated steroid need. Specify last dose and whether any taper applies.

Sources

Checked September 20, 2026.

Prednisone (Deltasone)Bell palsy, off-label

What to say

Your examination fits Bell palsy. Starting prednisone, a steroid, within 3 days of the first symptoms improves the chance of full recovery. Guidelines recommend this off-label use. Take 60 milligrams each morning with food for 5 days, then lower the dose by 10 milligrams each day for 5 more days, following the written schedule. If your eye doesn’t close fully, use lubricating drops by day; at night, use ointment and tape the lid closed as we showed you.

Prednisone can disturb sleep, increase appetite, affect mood and raise blood sugar; if you have diabetes, check your sugar more often. Most people start improving within 2–3 weeks. Get same-day eye care for eye pain, redness or blurred vision. Call 911 for arm or leg weakness or numbness, trouble speaking, confusion or a sudden severe headache. Call us the same day for blisters on or in the ear or worsening weakness, and call if your face hasn’t fully recovered by 3 months.

Clinical reference

Dose options

Adults 16 and older, within 72 hours of onset

60 mg each morning on days 1–5, then 50, 40, 30, 20 and 10 mg on days 6–10

AAO-HNSF regimen (from the Engström trial). Guideline alternative: 50 mg daily for 10 days. Benefit after 72 hours is uncertain. Bell palsy is not a labeled prednisone indication.

Optional antiviral add-on

Valacyclovir 1 g three times daily for 7 days, or acyclovir 400 mg five times daily for 10 days, given with the steroid

AAO-HNSF 2013 option with shared decision-making; possible small benefit, mainly less synkinesis. Never use an antiviral alone. Reduce valacyclovir for CrCl <50 mL/min.

  • AAO-HNSF 2013: oral steroid within 72 hours for ages 16 and older (strong); antiviral alone not recommended; antiviral add-on is an option. An AAO-HNSF update in development (public comment April 2026) lists antiviral plus high-dose steroid as a recommendation; final guideline pending.

Before prescribing

Confirm a peripheral palsy (forehead involved), onset within 72 hours and an otherwise normal neurologic exam. Look for ear vesicles, otitis, parotid or skin lesions and Lyme exposure. Review diabetes, psychiatric history and infection risk; individualize in pregnancy.

Side effects and return precautions

Insomnia, mood change, hyperglycemia, BP rise. Limb or speech deficits, other cranial neuropathies or gradual progression suggest another diagnosis. Eye pain, irritation or vision change needs prompt eye-specialist review.

Follow-up

Check eye protection and glucose early. Reassess or refer to a facial nerve specialist for new or worsening neurologic findings, eye symptoms, or incomplete recovery at 3 months (AAO-HNSF).

Sources

Checked October 15, 2026.

Prednisone (Deltasone)COPD exacerbation, off-label

What to say

For this COPD flare, take prednisone 40 milligrams each morning with food for five days. Keep following your inhaler and oxygen plan. This short course reduces inflammation. It doesn’t replace a rescue inhaler. We’ll write down the last dose and account for any steroids you already take.

It can disturb sleep, increase appetite, affect mood and raise blood sugar. We’ll make a glucose-check plan if needed. Contact us promptly for marked mood changes or worsening symptoms. Severe breathlessness, blue lips, new confusion or inability to stay awake means call 911. We’ll review your recovery within the next few days.

Clinical reference

Dose options

Adult COPD exacerbation

Prednisone 40 mg daily for 5 days

Guideline-supported off-label indication. GOLD prednisone-equivalent regimen. A single short course usually does not need a taper; chronic/recent repeated steroid exposure requires an individualized stop plan.

Before prescribing

Assess severity and alternative diagnoses, including pneumonia, HF and pulmonary embolism. Review oxygenation, diabetes, mood/infection risks and cumulative steroid exposure. Severe or unstable illness needs immediate assessment.

Side effects and return precautions

Insomnia, appetite, mood and glucose changes; infection and GI risks. Severe mood disturbance, psychosis or inability to stay safe requires urgent/emergency assessment. Avoid unsupervised NSAID combinations.

Follow-up

Arrange review within a few days and reassess inhalers, technique, recovery and exacerbation prevention. Specify stop date; do not automatically extend the course.

Sources

Checked September 23, 2026.

Prednisone (Deltasone)Polymyalgia rheumatica

What to say

For polymyalgia rheumatica, take prednisone 15 milligrams each morning with food. Most people feel much less stiff within days; if not, tell us, because we may need to rethink the diagnosis. Once you’re better, we’ll lower the dose slowly, aiming for 10 milligrams by about 2 months, then in small steps every few weeks, guided by symptoms and blood tests. We aim to stop within about a year, but flare-ups are common and some people need longer. Never stop suddenly or change the dose yourself.

Prednisone can raise blood sugar, blood pressure and weight, disturb sleep and mood, raise infection risk and thin bones. We’ll check bone density and plan calcium, vitamin D and possibly a bone medicine. If you’re vomiting and can’t keep doses down, or become seriously ill, get same-day care. A new headache, scalp tenderness or jaw pain when chewing means call us the same day. Any change in vision means go to the emergency department now.

Clinical reference

Dose options

New-onset PMR (EULAR 2025)

15–25 mg once each morning; taper to 10 mg/day within 1–2 months, then slowly (2015 EULAR/ACR: 1 mg every 4 weeks while in remission), aiming to stop within 1 year

Choose the start and pace for relapse risk and steroid-sensitive comorbidities. EULAR 2025 does not routinely recommend split, alternate-day, IM or modified-release regimens.

Relapse

Restart or increase to at least the last effective dose, then taper individually

Confirm with symptoms and ESR/CRP; PMR can relapse as GCA. Repeated relapse or steroid toxicity: rheumatology for an IL-6 receptor inhibitor (sarilumab is FDA-approved for PMR) or methotrexate.

Low doses and stopping

Below 5 mg/day, small variable-day steps may help avoid adrenal insufficiency

Adrenal insufficiency can mimic a PMR relapse. HPA suppression can persist for months after stopping; cover major illness or surgery.

  • Immediate-release prednisone labels do not name PMR; delayed-release prednisone labeling lists it. EULAR 2025 (published July 2026) moves the starting range from 12.5–25 mg (2015 EULAR/ACR) to 15–25 mg.

Before prescribing

Confirm PMR and exclude mimics (RA, myositis, hypothyroidism, infection, cancer); EULAR 2025 advises specialist assessment. Ask about GCA symptoms. Record baseline BP, A1c, weight and fracture risk; screen for hepatitis B before prolonged therapy.

Side effects and return precautions

Hyperglycemia, hypertension, weight gain, insomnia, mood change, infection, cataract, glaucoma, myopathy, fracture. New headache, scalp tenderness, jaw claudication or visual symptoms need same-day GCA assessment; vision loss is an emergency.

Follow-up

Review symptoms, ESR/CRP, BP, glucose and weight at each taper step. BMD with vertebral assessment soon after starting, then every 1–2 years (ACR 2022). Refer refractory or relapsing disease.

Sources

Checked October 15, 2026.

Prednisone (Deltasone)Severe poison oak

What to say

Because your poison oak rash is widespread [or on your face or genitals], we’re treating it with prednisone. Take [dose] milligrams each morning with food for [5–7] days, then lower the dose as written over a total of 2–3 weeks. Finish the taper even if the rash looks better, because stopping early can make it flare back. Wash clothes and gear that touched the plant, and rinse your pet’s fur, so the oil doesn’t keep spreading.

Cool compresses, short cool showers and calamine lotion ease itching, and an antihistamine pill may help. Don’t put antihistamine cream on the rash, and leave blisters alone. Prednisone can cause trouble sleeping, mood changes, hunger and higher blood sugar; if you have diabetes, check your sugar more often. Call the same day for pus, spreading redness, fever or new swelling around your eyes. Call 911 for trouble breathing or swallowing.

Clinical reference

Dose options

Extensive (>20% of skin) or severe dermatitis, including face or genitals

Prednisone 0.5–1 mg/kg/day (e.g., 40–60 mg) each morning for 5–7 days, then about half for 5–7 days; taper over 2–3 weeks in total

AAFP regimen: rapid discontinuation can cause rebound; avoid prepackaged steroid dose packs (insufficient dose and duration). The label lists severe contact dermatitis among allergic states.

Localized rash

Mid- or high-potency topical steroid (e.g., triamcinolone 0.1% or clobetasol 0.05%) away from the face and folds

Use lower-potency steroids on thin skin. Cool compresses, calamine and oral antihistamines for itch; avoid topical antihistamines (AAD).

Before prescribing

Confirm extent, face, genital or eyelid involvement and secondary infection. Review diabetes, hypertension, heart failure, peptic ulcer or NSAID use, psychiatric history, glaucoma, infection (systemic fungal infection contraindicated) and pregnancy. Defer live vaccines.

Side effects and return precautions

Insomnia, mood change or psychosis, hyperglycemia, fluid retention, BP rise and dyspepsia. Rebound if tapered too fast. Impetiginized or cellulitic lesions need antibiotics; airway or periorbital swelling needs urgent assessment.

Follow-up

Review if not improving within 2–3 days or worse at any point. Persistent or recurrent rash suggests re-exposure from contaminated clothing, gear or pets, or another diagnosis; patch test when the allergen is unclear.

Sources

Checked October 15, 2026.

Pregabalin (Lyrica)Diabetic nerve pain

What to say

For the painful nerve damage from diabetes, start immediate-release pregabalin 50 milligrams three times daily. We’ll review how it affects pain, sleep and activity before increasing. It treats the pain but doesn’t replace glucose management or daily foot checks.

Sleepiness, dizziness, blurred vision, ankle swelling or weight gain can happen. Tell us if they’re troublesome, and don’t drive until you know how it affects you. Avoid alcohol and don’t add opioids or other medicines that make you sleepy without checking. Slow or shallow breathing, difficulty waking, or swelling of the tongue or throat means stop it and call 911. Call the same day for new thoughts of self-harm. Immediate danger means call 911. We’ll check in within one to two weeks. For ordinary stopping, we’ll reduce it gradually rather than stopping suddenly.

Clinical reference

Dose options

Diabetic nerve pain

50 mg three times daily; may increase to 100 mg three times daily within one week

CrCl ≥60: recommended maximum 300 mg/day; higher doses add adverse effects without established additional benefit.

Renal adjustment/stopping

Adjust total dose and frequency using CrCl; taper over at least one week

Hemodialysis requires supplemental dosing. Immediate-release capsule instructions do not apply to Lyrica CR.

Before prescribing

Calculate renal function before selecting dose. Review respiratory disease, opioids/CNS depressants, edema/heart failure, misuse risk and suicidality. Do not routinely combine with gabapentin.

Side effects and return precautions

Dizziness/somnolence, edema and blurred vision; respiratory depression, angioedema and suicidal thoughts require clear action plans.

Follow-up

Review tolerability, renal dosing, pain and a functional goal within 1–2 weeks, then titrate only for useful additional benefit. Plan gradual discontinuation if ineffective.

Sources

Checked September 22, 2026.

Pregabalin (Lyrica)Fibromyalgia

What to say

For fibromyalgia, start immediate-release pregabalin 75 milligrams twice daily. The aim is to make pain more manageable and help you function, alongside the activity and sleep plan we discussed. We’ll check the response before increasing. It may not remove all pain.

Sleepiness, dizziness, blurred vision, ankle swelling or weight gain can happen. Tell us if they’re troublesome, and don’t drive until you know how it affects you. Avoid alcohol and don’t add opioids or other medicines that make you sleepy without checking. Slow or shallow breathing, difficulty waking, or swelling of the tongue or throat means stop it and call 911. Call the same day for new thoughts of self-harm. Immediate danger means call 911. We’ll check in within one to two weeks. For ordinary stopping, we’ll reduce it gradually rather than stopping suddenly.

Clinical reference

Dose options

Fibromyalgia

75 mg twice daily; may increase to 150 mg twice daily within one week

CrCl ≥60: if needed and tolerated, maximum 225 mg twice daily (450 mg/day).

Renal adjustment/stopping

Adjust total dose and frequency using CrCl; taper over at least one week

Hemodialysis requires supplemental dosing. Immediate-release capsule instructions do not apply to Lyrica CR.

Before prescribing

Calculate renal function before selecting dose. Review respiratory disease, opioids/CNS depressants, edema/heart failure, misuse risk and suicidality. Do not routinely combine with gabapentin.

Side effects and return precautions

Dizziness/somnolence, edema and blurred vision; respiratory depression, angioedema and suicidal thoughts require clear action plans.

Follow-up

Review tolerability, renal dosing, pain and a functional goal within 1–2 weeks, then titrate only for useful additional benefit. Plan gradual discontinuation if ineffective.

Sources

Checked September 22, 2026.

Pregabalin (Lyrica)Focal seizures, add-on treatment

What to say

Pregabalin is an additional medicine for your focal seizures. It doesn’t replace your existing seizure medicines. Take the immediate-release dose at the times on your neurology plan, usually twice or three times daily. We’ll adjust it from seizure control, side effects and kidney function. Keep a seizure record and don’t stop suddenly.

Dizziness, sleepiness, blurred vision, swelling or weight gain can occur. Avoid alcohol and check before using other sedating medicines. Don’t drive until your epilepsy team confirms it’s safe and permitted. Call promptly for mood changes or thoughts of self-harm. Immediate danger means call 911. Slow breathing or difficulty waking needs emergency help. Stop it and call 911 for tongue or throat swelling.

Follow your seizure action plan. Call 911 for a seizure lasting more than five minutes, repeated seizures without recovery, or trouble breathing or waking afterward.

Clinical reference

Dose options

Adult adjunctive focal-seizure treatment, CrCl ≥60

Start total 150 mg/day in two or three doses; individualized increases up to 600 mg/day

Examples of the starting schedule are 75 mg twice daily or 50 mg three times daily. Use the epilepsy team’s escalation plan.

Renal function and formulation

Reduce total dose/frequency when renal function is impaired; hemodialysis needs supplemental dosing

These instructions are for immediate-release Lyrica, not Lyrica CR. Taper planned withdrawal over at least one week under the epilepsy team.

Before prescribing

Confirm seizure type and adjunctive role. Check renal function, pregnancy plans, respiratory disease, sedatives, edema/heart failure, mood and misuse risk. Do not routinely combine with gabapentin.

Side effects and return precautions

Monitor sedation, coordination, vision, edema and mood. Respiratory depression and angioedema require urgent action; abrupt withdrawal can worsen seizures.

Follow-up

Review seizure frequency and tolerability during each planned titration. Agree who manages dose changes, refills and rescue treatment; contact the team promptly for breakthrough seizures.

Sources

Checked September 23, 2026.

Pregabalin (Lyrica)Nerve pain after spinal cord injury

What to say

Pregabalin can reduce the burning or shooting nerve pain from your spinal cord injury. It doesn’t repair the injury. For this plan, start the immediate-release capsules at 75 milligrams twice daily, with or without food. Kidney problems may require less. We’ll judge benefit by pain, sleep and your rehabilitation goals before increasing.

Sleepiness, dizziness, blurred vision, swelling or weight gain can happen. Tell us if these affect transfers or daily activities. Alcohol, opioids and medicines for muscle spasms may add to sedation, so we’ll review them together. Call 911 for slow breathing or difficulty waking. Stop it and call 911 for tongue or throat swelling. Report new thoughts of self-harm promptly. Immediate danger needs 911. We’ll taper it if it isn’t helping.

Clinical reference

Dose options

Adult spinal-cord-injury neuropathic pain, CrCl ≥60

75 mg twice daily; may increase to 150 mg twice daily within one week if needed and tolerated

If relief remains inadequate after 2–3 weeks at 150 mg twice daily, may increase up to 300 mg twice daily. Higher dosing requires useful benefit and tolerability.

Renal adjustment and stopping

Use the renal dosing table; taper over at least one week when discontinuing

Dialysis needs supplemental dosing. Immediate-release capsules/solution only; do not substitute Lyrica CR schedules.

Before prescribing

Confirm neuropathic pain rather than a new injury or other pain source. Check renal function, respiratory reserve, sedatives/antispasticity medicines, edema, mood, pregnancy and misuse risk.

Side effects and return precautions

Monitor alertness, safe transfers, edema and respiratory effects. New weakness, fever or a marked change from usual pain warrants assessment of the cause rather than automatic dose escalation.

Follow-up

Review in 1–2 weeks during initiation, with rehabilitation/pain-team coordination. Record a functional goal and reassess benefit before every increase.

Sources

Checked September 23, 2026.

Pregabalin (Lyrica)Pain after shingles

What to say

For the nerve pain that has continued after shingles, start the immediate-release pregabalin capsule at 75 milligrams twice a day. You can take it with or without food. The goal is less pain and better sleep or activity. It may not remove every symptom. We’ll review the response before increasing.

Sleepiness, dizziness, blurred vision, ankle swelling or weight gain can happen. Tell us if they’re troublesome, and don’t drive until you know how it affects you. Avoid alcohol and don’t add opioids or other medicines that make you sleepy without checking. Slow or shallow breathing, difficulty waking, or swelling of the tongue or throat means stop it and call 911. Call the same day for new thoughts of self-harm. Immediate danger means call 911. We’ll check in within one to two weeks. For ordinary stopping, we’ll reduce it gradually rather than stopping suddenly.

Clinical reference

Dose options

Postherpetic neuralgia, CrCl ≥60

Start 75 mg twice daily or 50 mg three times daily

May increase to total 300 mg/day within one week if needed and tolerated.

Persistent postherpetic pain

Up to 600 mg/day in divided doses after 2–4 weeks at 300 mg/day if inadequate and tolerated

Reserve higher doses for ongoing pain; diabetic neuropathy and fibromyalgia have different recommended ceilings.

Renal adjustment/stopping

Adjust total dose and frequency using CrCl; taper over at least one week

Hemodialysis requires supplemental dosing. Immediate-release capsule instructions do not apply to Lyrica CR.

Before prescribing

Calculate renal function before selecting dose. Review respiratory disease, opioids/CNS depressants, edema/heart failure, misuse risk and suicidality. Do not routinely combine with gabapentin.

Side effects and return precautions

Dizziness/somnolence, edema and blurred vision; respiratory depression, angioedema and suicidal thoughts require clear action plans.

Follow-up

Review tolerability, renal dosing, pain and a functional goal within 1–2 weeks, then titrate only for useful additional benefit. Plan gradual discontinuation if ineffective.

Sources

Checked September 22, 2026.

Pregabalin (Lyrica)Restless legs syndrome, off-label

What to say

We’re trying pregabalin off-label to reduce the uncomfortable urge to move your legs in the evening. Start 75 milligrams about one to two hours before symptoms usually begin. We may choose a lower dose based on your age or kidney function. We’ll also check iron levels and other factors that can worsen restless legs.

Sleepiness, dizziness, blurred vision or swelling can occur. Avoid driving until you know its effect, and check before combining it with alcohol, opioids or other sedatives. Call 911 for slow breathing, difficulty waking or tongue swelling. Contact us for new self-harm thoughts. Immediate danger needs emergency help. We’ll reduce it gradually if stopping.

Clinical reference

Dose options

Evening starting dose

75 mg daily 1–2 hours before usual symptoms; consider 50 mg if older than 65

Increase cautiously under the written plan; many patients respond at 150–450 mg/day, but renal function and sedation limit dosing.

Renal adjustment

Adjust dose to creatinine clearance; lower doses are needed below 60 mL/min

Use immediate-release pregabalin, not an ER substitution. Hemodialysis needs a separate plan.

Before prescribing

Confirm RLS, check ferritin/transferrin saturation and renal function, and address aggravating medicines and untreated sleep apnea. Review falls, sedatives, respiratory disease, edema/HF, pregnancy and misuse risk; do not routinely combine with gabapentin.

Side effects and return precautions

Dizziness/somnolence, edema and blurred vision; respiratory depression, angioedema and suicidal thoughts require clear action plans.

Follow-up

Review symptoms, sleep and next-day sedation in 1–2 weeks. Address iron deficiency with an RLS-specific plan. Taper over at least one week, often longer, when stopping.

Sources

Checked September 23, 2026.

Primidone (Mysoline)Essential tremor, off-label

What to say

Primidone is a seizure medicine that also reduces essential tremor; this is an off-label use. Start with 25 milligrams, half of a 50-milligram tablet, at bedtime. Early doses can cause dizziness, unsteadiness, nausea or a hungover, flu-like feeling, which is why we start low and at night. If you tolerate it, we’ll raise the dose slowly, about once a week, on a written schedule, until the tremor improves or side effects limit it.

Sleepiness and poor balance can last, so don’t drive until you know its effect, and take care to prevent falls. Alcohol, sleep and anxiety medicines, and opioids add to the drowsiness. Primidone makes hormonal birth control less reliable and changes levels of blood thinners and many other medicines, so check before starting anything new. Call us for a rash, fever, mouth sores or unusual bruising. Contact us promptly for thoughts of self-harm; immediate danger means call 911. Don’t stop it suddenly; we’ll taper.

Clinical reference

Dose options

Essential tremor start (off-label)

12.5–25 mg (¼–½ of a 50 mg tablet) at bedtime

Increase gradually to the lowest dose that controls tremor; doses can be divided. AAN case example: 25 mg twice daily, raised every 5 days to 100 mg/day. IETF suggests starting at 12.5 mg.

Combination and long-term use

May combine with propranolol when monotherapy is insufficient (AAN Level B)

Doses may need increasing by 12 months (Level C). Seizure-label doses (up to 2 g/day) are not the tremor target.

  • Off-label in the US (propranolol is the only FDA-approved ET drug); the AAN rates propranolol and primidone Level A, reaffirmed in 2025.

Before prescribing

Confirm ET and exclude drug-induced, thyroid or parkinsonian tremor. Contraindicated in porphyria and phenobarbital hypersensitivity. Review falls, cognition, depression, alcohol and sedatives, pregnancy potential, and enzyme-inducer interactions (hormonal contraception, warfarin, DOACs, other antiseizure drugs).

Side effects and return precautions

Early ataxia, vertigo, nausea and sedation; later fatigue, mood or cognitive change and suicidality. Rare agranulocytosis, red-cell aplasia, megaloblastic anemia (folate-responsive) and rash. Recheck INR and contraception after starting or stopping.

Follow-up

Review tremor, function, sedation and falls after each increase. The label advises CBC and chemistry every 6 months with prolonged therapy. Taper rather than stop abruptly.

Sources

Checked October 15, 2026.

Promethazine (Phenergan)Nausea and vomiting

What to say

Promethazine can ease nausea, but it can make you very sleepy. Take [prescribed dose] by mouth every [prescribed interval] hours only if needed, through [stop date]. Don’t drive while affected. Avoid alcohol and check with us before combining it with opioids, sleeping pills or other sedating medicines.

Dry mouth, dizziness or constipation can happen. Call 911 for slow breathing or difficulty waking. Stop it and seek urgent care for new muscle spasms, unusual movements, or fever with stiff muscles and confusion. Contact us if you can’t keep fluids down, are urinating very little, or vomiting continues. Severe abdominal pain or blood in vomit needs urgent assessment.

Clinical reference

Dose options

Adult oral label dosing

Usual effective dose 25 mg; 12.5–25 mg may be repeated every 4–6 hours as needed

Select the dose, interval, daily limit and short course for the individual; use the lowest effective dose.

Before prescribing

Review cause of vomiting, pregnancy, age/fall risk, respiratory disease, sleep apnea, glaucoma, urinary retention, seizures and sedatives. Avoid with compromised respiratory function; contraindicated under age 2 because of potentially fatal respiratory depression. This covers adult oral dosing only, not pediatric or injectable use.

Side effects and return precautions

Sedation, anticholinergic effects and respiratory depression; possible dystonia and neuroleptic malignant syndrome.

Follow-up

Set a short reassessment interval and explicit stop date; persistent vomiting requires diagnostic review rather than automatic refills.

Sources

Checked September 24, 2026.

Propranolol (Inderal LA)Migraine prevention

What to say

Propranolol is a daily medicine to make migraines less frequent and less severe. It won’t stop an attack that has already started, so keep your separate plan for attacks. Start Inderal LA 80 milligrams once a day. If you’re tolerating it, we’ll raise it step by step, usually to 160 milligrams once a day. Keep a headache diary. We’ll judge whether it’s working after 2–3 months at a steady dose.

Tiredness, dizziness, cold hands, vivid dreams or erection problems can happen. Call us for wheezing, fainting, a very slow pulse or ankle swelling. Chest pain or severe trouble breathing means call 911. Don’t stop it suddenly; we’ll taper it if needed. If you use rizatriptan, take only 5 milligrams per dose. If you use insulin or diabetes pills, it can hide the warning signs of low blood sugar. Tell us about low mood or thoughts of self-harm, because a propranolol overdose is dangerous.

Clinical reference

Dose options

Migraine prevention, Inderal LA

80 mg once daily; increase gradually; usual effective dose 160–240 mg once daily

Label: stop, with a taper, if no satisfactory response 4–6 weeks after reaching the maximum dose. 2026 AAN/AHS: judge efficacy after 8–12 weeks at the target tolerated dose.

Immediate-release alternative

80 mg/day in divided doses; usual 160–240 mg/day

Inderal LA is not mg-for-mg interchangeable with immediate-release tablets; retitrate when switching.

With rizatriptan

Rizatriptan 5 mg per dose, maximum 3 doses (15 mg) in 24 hours

Propranolol raises rizatriptan exposure about 70% (Maxalt label).

  • 2026 AAN/AHS guideline (August 2026): propranolol is a higher-confidence option for episodic migraine and for patients concerned about long-term harms; it is not on the chronic migraine list.

Before prescribing

Offer prevention for 4 or more migraine days a month or disabling attacks. Contraindicated: asthma, sinus bradycardia, AV block above first degree. Caution: HF, COPD, insulin or sulfonylurea use, depression or self-harm risk, Raynaud. Review rizatriptan and AV-nodal drugs.

Side effects and return precautions

Fatigue, bradycardia, hypotension, bronchospasm, masked hypoglycemia, depression and sexual dysfunction. Abrupt withdrawal can precipitate angina. Overdose is dangerous; NICE advises caution with depression or self-harm risk.

Follow-up

Review the diary and tolerance at each step; optimize the dose if response is suboptimal at 8 weeks; judge efficacy at 8–12 weeks (AAN/AHS 2026). After about 6 months of good control, discuss tapering.

Sources

Checked October 15, 2026.

Propranolol (Inderal)Essential tremor

What to say

Propranolol, a beta blocker, can reduce the shaking of essential tremor, though it doesn’t cure it. Start with 40 milligrams twice a day. We’ll raise the dose step by step, often to about 120 milligrams a day, depending on how much it helps and on your pulse and blood pressure. Cutting back on caffeine can also help. Alcohol may briefly calm a tremor, but it isn’t a safe treatment.

Tiredness, dizziness, cold hands, vivid dreams or erection problems can happen. Stand up slowly. Call us for wheezing, shortness of breath, ankle swelling, fainting or a very slow pulse. Chest pain or severe trouble breathing means call 911. Don’t stop it suddenly, because that can trigger chest pain or other heart problems; we’ll taper it if needed. If you use insulin or diabetes pills, it can hide the warning signs of low blood sugar. Tell us about low mood or thoughts of self-harm, because a propranolol overdose is dangerous.

Clinical reference

Dose options

Essential tremor, immediate-release tablets

40 mg twice daily; titrate to the usual 120 mg/day in divided doses; occasionally 240–320 mg/day

Labeled regimen. Start lower in older adults. Primidone is the other Level A first-line drug (AAN).

Long-acting capsules

Inderal LA once daily is sometimes used for convenience but is not labeled for tremor

Not a mg-for-mg substitute for immediate-release tablets; retitrate when switching. Not for tremor from parkinsonism.

  • Only immediate-release propranolol tablet labeling lists essential tremor; Inderal LA labeling does not. AAN rates propranolol and primidone Level A (2011 update, reaffirmed July 2025).

Before prescribing

Confirm essential tremor; review drug, caffeine and thyroid causes. Contraindicated: asthma, sinus bradycardia, AV block above first degree. Caution: HF, COPD, insulin or sulfonylurea use, depression, Raynaud, pregnancy. Review verapamil, diltiazem, digoxin, clonidine, fluoxetine.

Side effects and return precautions

Bradycardia, hypotension, fatigue, bronchospasm, HF, masked hypoglycemia, depression and sexual dysfunction. Abrupt withdrawal can precipitate angina, MI or thyroid storm. Overdose is dangerous; limit supply with self-harm risk.

Follow-up

Recheck HR, BP and function after each dose step. If benefit is inadequate at a tolerated dose, taper over weeks and consider primidone or referral for DBS or focused ultrasound.

Sources

Checked October 15, 2026.

Propranolol (Inderal)Performance anxiety, off-label

What to say

For a known stressful event like a talk or performance, propranolol can calm the physical rush of nerves: a pounding heart, shaky hands or a trembling voice. It doesn’t stop worried thoughts. Using it this way is off-label. Take 10 to 20 milligrams 30 to 60 minutes before the event. Try a dose at home on an ordinary day first. Use it only for specific events, not every day; therapy or a daily medicine works better for ongoing anxiety.

You may feel tired or lightheaded, or have cold hands. Avoid alcohol with it, and don’t drive until you know how it affects you. Don’t take it if you have asthma. If you have diabetes, it can hide the shaky, racing-heart warning signs of low blood sugar. Tell us about other medicines, especially antidepressants, migraine or heart medicines. Call us about marked dizziness or an unusually slow pulse. Call 911 for fainting, wheezing or trouble breathing, or chest pain.

Clinical reference

Dose options

As needed before a predictable performance

10–20 mg orally once, 30–60 minutes before the event

Off-label; there is no US labeled anxiety dose. Give a test dose on a non-event day. Use immediate-release tablets, not extended-release capsules (Inderal LA, Inderal XL).

Cautions

Contraindicated in asthma, sinus bradycardia, AV block beyond first degree and cardiogenic shock

Use caution with hepatic or renal impairment and with CYP2D6, 1A2 or 2C19 inhibitors (fluoxetine, paroxetine, fluvoxamine), which raise levels.

  • No brand-name immediate-release Inderal tablet is listed on DailyMed; generic tablets are used (Inderal LA and XL are extended-release).

Before prescribing

Confirm performance-limited anxiety rather than social anxiety disorder, panic or GAD needing CBT or an SSRI. Exclude asthma or bronchospasm, bradycardia, heart block, hypotension, HF, insulin- or sulfonylurea-treated diabetes and interacting drugs (verapamil, diltiazem, rizatriptan).

Side effects and return precautions

Fatigue, dizziness, hypotension, bradycardia, cold extremities and bronchospasm; masked hypoglycemia. Alcohol raises propranolol levels. Frequent use suggests an anxiety disorder needing treatment.

Follow-up

Review the test-dose response and how the event went. Frequent or escalating use prompts assessment for social anxiety disorder and an offer of CBT or an SSRI.

Sources

Checked October 15, 2026.

Psyllium (Metamucil)Fiber for constipation and IBS

What to say

Psyllium is a soluble fiber supplement. It holds water in the stool, so stools become softer, bulkier and easier to pass. It can help constipation and IBS symptoms, and it eases straining with hemorrhoids or a fissure. Start with one dose a day, such as one Metamucil packet, stirred into at least 8 ounces of water or another drink. Drink it right away. Increase slowly, up to three doses a day if needed. It usually works within 12–72 hours.

Gas and bloating are common at first and usually settle. Take other medicines at least 2 hours before or after it. Without enough liquid it can swell and cause choking, so don’t take it if you have trouble swallowing. Call 911 for chest pain, vomiting, or trouble swallowing or breathing after a dose. Stop it and call us for hives or an itchy rash, rectal bleeding, constipation lasting more than 7 days, or no bowel movement.

Clinical reference

Dose options

Starting dose

1 dose daily (Metamucil: about 3.4 g psyllium husk) in at least 8 oz of fluid

Drug Facts: new users start with 1 dose a day and increase gradually. Psyllium per dose varies by brand and form, so use the label measure.

Usual target

Up to 3 doses daily (about 10 g psyllium); 20–30 g total fiber a day from diet plus supplement

Constipation trials used about 10 g/day of psyllium. AGA/ACG 2023: little added benefit above 25–30 g total fiber; encourage adequate fluids.

  • Drug Facts covers occasional constipation only; use for IBS, hemorrhoids and fissures rests on ACG guidance.

Before prescribing

Exclude dysphagia or esophageal narrowing, suspected obstruction or impaction, and alarm features. Review medicines needing 2-hour separation, fluid restriction, psyllium allergy, and phenylalanine in sugar-free versions.

Side effects and return precautions

Flatulence and bloating early. Choking or esophageal obstruction if taken with too little fluid; allergy in psyllium-sensitized people, including after inhaled exposure. New pain, bleeding or obstructive symptoms need assessment.

Follow-up

Review stool pattern and tolerance after a few weeks; add PEG for persistent constipation. In IBS, use soluble fiber rather than bran. Continue fiber after a fissure heals.

Sources

Checked October 15, 2026.

Quetiapine (Seroquel)Bipolar depression

What to say

For bipolar depression, take quetiapine once a day at bedtime, with or without food: 50 milligrams the first night, 100 the second, 200 the third, then 300 milligrams nightly. It often causes sleepiness, so take it right before bed. We’ll check in within 1 to 2 weeks.

Dizziness when standing, dry mouth, constipation, increased appetite and weight gain are common. Get up slowly, avoid alcohol, and don’t drive until you know how it affects you. It can raise blood sugar and cholesterol, so we’ll check your weight and blood tests. Call the same day for worsening mood, thoughts of self-harm, or unusually high energy with little need for sleep. If you might act on those thoughts, call 911. 988 can provide crisis support. Call 911 for fainting, or a high fever with stiff muscles or confusion. Tell us about new movements you can’t control, and don’t stop it suddenly.

Clinical reference

Dose options

Bipolar depression (immediate-release Seroquel)

Once daily at bedtime: day 1 50 mg, day 2 100 mg, day 3 200 mg, day 4 300 mg

Label recommended and maximum dose for bipolar depression: 300 mg/day; 600 mg was no more effective. CANMAT/ISBD 2018: first-line for bipolar I depression and the only first-line option for bipolar II depression. Confirm the schedule if using Seroquel XR.

Older adults, hepatic impairment, CYP3A4

Older adults: start 50 mg/day, increase by 50 mg/day; hepatic impairment: start 25 mg/day, increase by 25–50 mg/day

Strong CYP3A4 inhibitors: reduce to one-sixth of the dose; chronic strong inducers: increase up to 5-fold. Reverse the change when the interacting drug stops.

  • Low-dose quetiapine for insomnia alone is off-label and not advised; VA/DoD 2025 suggests against antipsychotics for chronic insomnia.

Before prescribing

Confirm the bipolar diagnosis and current episode; screen suicidality, substance use and pregnancy. Baseline weight, BP, fasting glucose or A1c and lipids; ECG if QT risk. Review CYP3A4 drugs, anticholinergic burden, cataract history and dementia (boxed warning).

Side effects and return precautions

Sedation, orthostasis/syncope, weight gain, hyperglycemia, dyslipidemia, anticholinergic effects; akathisia/EPS, tardive dyskinesia, NMS, QT prolongation, neutropenia, hypothyroidism and mania switch. Boxed warning: suicidality through age 24.

Follow-up

Review safety and sedation in 1–2 weeks, then response over the following weeks. Monitor weight, glucose and lipids periodically; lens exam at start and every 6 months per label. Taper rather than stop abruptly.

Sources

Checked October 15, 2026.

Rifampin (Rifadin)Latent TB infection

What to say

You have latent TB: the germ is in your body but inactive, so you aren’t sick or contagious. Treating it now lowers the chance of active TB later. Your symptoms and chest x-ray show no active disease. Take rifampin [dose], usually 600 milligrams, once a day for 4 months, 120 doses in all, on an empty stomach: 1 hour before or 2 hours after a meal.

Rifampin turns urine, sweat and tears orange-red; that’s harmless, but it can permanently stain soft contact lenses. It weakens many medicines, including hormonal birth control, blood thinners, methadone, buprenorphine and some HIV medicines, so we’ll review everything you take. Use a non-hormonal method, such as condoms or a copper IUD. Stop it and call us the same day for nausea, vomiting, belly pain, brown urine, yellow skin or eyes, unusual bruising or bleeding, or fever with aches. We’ll check in monthly.

Clinical reference

Dose options

Latent TB infection, 4R (HIV-negative adults)

10 mg/kg (maximum 600 mg) orally once daily for 4 months (120 doses)

CDC/NTCA 2020: preferred regimen, strong recommendation (moderate evidence). No evidence on effectiveness in people with HIV. Take 1 hour before or 2 hours after a meal.

Other preferred short-course regimens

3HP: isoniazid + rifapentine weekly for 12 weeks; 3HR: isoniazid + rifampin daily for 3 months

Choice depends on interactions, HIV regimen, pregnancy plans, adherence and the source case’s drug susceptibility.

Before prescribing

Exclude TB disease (symptoms, chest x-ray). Review all drugs: contraindicated with many HIV antiretrovirals; lowers DOACs, warfarin, opioids, azoles and hormonal contraceptives. Baseline LFTs if liver disease, alcohol use, HIV or pregnancy.

Side effects and return precautions

Hepatitis (hold if ALT >3× ULN with symptoms or >5× without), flu-like syndrome, thrombocytopenia, thrombotic microangiopathy, hypersensitivity, GI upset. Orange body fluids are expected.

Follow-up

Monthly visits for adherence, TB symptoms and adverse effects; monthly LFTs if baseline abnormal or at risk. Document completion of 120 doses.

Sources

Checked October 15, 2026.

Rifaximin (Xifaxan)IBS with diarrhea

What to say

Rifaximin is an antibiotic that stays mostly in the gut. For IBS with diarrhea, it can ease diarrhea, urgency, bloating and belly pain. Take 550 milligrams 3 times a day, with or without food, for 14 days. The benefit can last weeks after the course. If symptoms improve and later return, the course can be repeated up to 2 more times. Insurance usually needs prior approval.

Side effects are uncommon; nausea can happen. Rarely, antibiotics cause a serious bowel infection called C. diff: call us the same day for frequent watery diarrhea worse than your usual IBS, especially with fever, even weeks later. Call 911 for face or throat swelling or trouble breathing; stop it and call us for a rash. Tell us if you take warfarin or cyclosporine. Call us for blood in your stool, weight loss or fever.

Clinical reference

Dose options

IBS-D

550 mg orally three times daily for 14 days

Recurrence: retreat up to 2 times with the same regimen. ACG 2021: strong recommendation; AGA 2022 suggests use and retreatment for initial responders.

Other indications differ

Hepatic encephalopathy: 550 mg twice daily; travelers’ diarrhea: 200 mg three times daily for 3 days

Don’t transpose regimens. Not effective for diarrhea with fever or blood, or for Campylobacter, Shigella or Salmonella.

Hepatic / interactions

Caution in Child-Pugh C and with P-gp inhibitors such as cyclosporine

Monitor INR with warfarin; dose changes may be needed.

Before prescribing

Confirm IBS-D by symptom criteria; exclude alarm features and, as indicated, celiac disease, IBD (fecal calprotectin) and infection. Check rifamycin hypersensitivity, warfarin, cyclosporine, severe hepatic impairment and prior authorization.

Side effects and return precautions

Nausea, ALT increase (about 2%); C. difficile infection (rare); hypersensitivity including exfoliative dermatitis, angioedema and anaphylaxis. Worsening diarrhea with fever or blood needs testing.

Follow-up

Assess response 2–4 weeks after the course (pain, stool form, bloating). Offer retreatment for recurrence after an initial response, up to 2 times; otherwise consider other IBS-D therapies.

Sources

Checked October 15, 2026.

Rimegepant (Nurtec ODT)Acute migraine and prevention

What to say

Rimegepant blocks CGRP, a chemical that helps trigger migraine. It works differently from triptans, so it can be an option when they don’t work or aren’t suitable. To treat an attack, take one 75-milligram tablet when the migraine starts. If we’re using it for prevention, take one tablet every other day. Never take more than one tablet in 24 hours. Peel back the foil with dry hands and let the tablet melt on or under your tongue.

Nausea or an upset stomach can happen. Check your blood pressure in the first week or two and tell us if it rises. Fingers or toes turning white or blue with pain means stop it and call us. Allergic reactions can start days after a dose: call the same day for a rash, and call 911 for throat or face swelling or trouble breathing. Ask us before starting antibiotics, antifungals, heart or seizure medicines, or St. John’s wort. Insurance often requires prior approval.

Clinical reference

Dose options

Acute treatment

75 mg ODT once as needed; maximum 75 mg in 24 hours

Safety of more than 18 doses in 30 days is not established. With a moderate CYP3A4 inhibitor or potent P-gp inhibitor, no second dose within 48 hours; avoid strong CYP3A4 inhibitors and strong or moderate CYP3A inducers.

Episodic migraine prevention

75 mg ODT every other day

AHS (2024) calls CGRP-targeting therapies a first-line prevention option; ACP (2025) places gepants second-line, after a beta-blocker, valproate, venlafaxine or amitriptyline. Judge benefit after about 12 weeks.

Hepatic and renal

Avoid in severe hepatic impairment (Child-Pugh C) and ESRD (CrCl <15 mL/min)

No adjustment for mild–moderate hepatic or mild–severe renal impairment.

  • No vascular contraindications in the label, unlike triptans; the label now warns of hypertension and Raynaud phenomenon.

Before prescribing

Confirm migraine and the goal (acute, prevention or both). Check BP and hypertension history, Raynaud phenomenon, prior hypersensitivity, severe hepatic impairment, ESRD, CYP3A4 and P-gp interactions, pregnancy plans and coverage.

Side effects and return precautions

Nausea, dyspepsia. Serious hypersensitivity, sometimes delayed by days; new or worsened hypertension, most often within 7 days of starting; Raynaud phenomenon. Frequent acute use should prompt prevention review.

Follow-up

Review the headache diary, acute-treatment days and BP within 1–3 months; judge prevention at about 12 weeks. Stop for hypersensitivity, Raynaud phenomenon or BP rise without another cause.

Sources

Checked October 15, 2026.

Rivaroxaban (Xarelto)Atrial fibrillation

What to say

For atrial fibrillation, rivaroxaban lowers your chance of a stroke. Take 20 milligrams once a day with your evening meal, or 15 milligrams if your kidney function is lower. Food helps your body absorb it. If you miss a dose, take it that same day when you remember, but never take 2 doses in 1 day. Don’t stop it, even briefly, without a plan from us. Tell any dentist or surgeon that you take it.

Bruising and minor bleeding can happen. Call us the same day about repeated nosebleeds, blood in your urine or bleeding that worries you. Go to the emergency department for black or bloody stools, vomiting blood or any head injury. Call 911 for bleeding that won’t stop, fainting, a sudden severe headache, a drooping face, arm weakness or trouble speaking. Check with us before taking aspirin, ibuprofen, naproxen, supplements or new prescriptions. We’ll check your kidney function and blood count regularly.

Clinical reference

Dose options

Nonvalvular AF, CrCl >50 mL/min

20 mg orally once daily with the evening meal

Calculate CrCl with actual body weight. The 15 and 20 mg tablets need food for full absorption; the 2023 guideline table says with the largest meal.

CrCl 15–50 mL/min

15 mg once daily with the evening meal

The label also allows 15 mg for CrCl <15 or dialysis based on pharmacokinetics alone; the 2023 guideline instead suggests warfarin or apixaban there (Class 2b).

Interactions, liver and procedures

Avoid combined P-gp and strong CYP3A inhibitors (ketoconazole, ritonavir) or inducers (rifampin, carbamazepine, phenytoin, St. John’s wort)

With combined P-gp and moderate CYP3A inhibitors (e.g., erythromycin), use at CrCl 15 to <80 only if benefit justifies risk. Avoid Child-Pugh B/C. Procedures (CrCl >30): hold 1 full day before low and 2 days before high bleeding-risk procedures; label minimum 24 hours.

Before prescribing

Confirm stroke risk (CHA2DS2-VASc), weight, CrCl, CBC, LFTs, bleeding history, pregnancy and interacting drugs (antiplatelets, NSAIDs, SSRIs/SNRIs). Not for mechanical valves, moderate–severe rheumatic mitral stenosis or triple-positive antiphospholipid syndrome.

Side effects and return precautions

Bleeding, including GI and intracranial. Boxed warnings: thrombosis after premature discontinuation, and spinal/epidural hematoma with neuraxial procedures. Taking 15 or 20 mg without food lowers absorption.

Follow-up

Review adherence, food timing and bleeding after starting. Reassess CrCl, CBC and LFTs periodically and when illness may lower CrCl; change the dose if CrCl crosses 50. No INR monitoring.

Sources

Checked October 15, 2026.

Rivaroxaban (Xarelto)DVT or pulmonary embolism treatment

What to say

For your blood clot, take rivaroxaban 15 milligrams twice a day with food for 21 days, then 20 milligrams once a day with food starting [date]. This keeps the clot from growing while your body clears it. If you miss a dose in the first 21 days, take it as soon as you remember; two 15-milligram tablets together that day are OK. After that, take a missed dose the same day, but never 2 doses in 1 day.

Bruising and minor bleeding can happen. Call us the same day about repeated nosebleeds, blood in your urine or bleeding that worries you. Go to the emergency department for black or bloody stools, vomiting blood or any head injury. Call 911 for new chest pain, sudden shortness of breath, fainting, a sudden severe headache or bleeding that won’t stop. Check before using aspirin, ibuprofen, naproxen or new medicines. Don’t stop early; treatment usually lasts at least 3 months.

Clinical reference

Dose options

Acute DVT or PE (CrCl ≥15 mL/min)

15 mg twice daily with food for 21 days, then 20 mg once daily with food

No parenteral lead-in. The 30-day starter pack holds 42 × 15 mg and 9 × 20 mg tablets. A missed dose in the twice-daily phase is taken at once to reach 30 mg that day.

Extended prevention

10 mg once daily, with or without food, after ≥6 months of standard treatment

For continued recurrence risk. The label requires 6 months first; ASH 2020 accepts a standard or lower-dose DOAC once primary treatment (3–6 months) is complete.

Renal, hepatic and interactions

Avoid CrCl <15 mL/min or Child-Pugh B/C; observe closely at CrCl 15–30

Avoid combined P-gp and strong CYP3A inhibitors or inducers. Not a substitute for heparin in hemodynamically unstable PE or when thrombolysis or embolectomy is planned.

Before prescribing

Confirm diagnosis, hemodynamic stability and outpatient suitability, weight, CBC, CrCl, LFTs, bleeding risk, pregnancy and interacting drugs. Not for mechanical valves or triple-positive antiphospholipid syndrome; pregnancy needs a different plan.

Side effects and return precautions

Bleeding, including GI, uterine and intracranial; recurrent DVT/PE symptoms; spinal/epidural hematoma with neuraxial procedures. Missing the day-22 switch leaves the patient on the higher twice-daily dose.

Follow-up

Confirm starter-pack use and the day-22 switch. Review bleeding, CBC and renal function. Treat at least 3 months; decide on extended therapy by provoked versus unprovoked VTE at 3–6 months.

Sources

Checked October 15, 2026.

Rizatriptan (Maxalt, Maxalt-MLT)Acute migraine

What to say

Take rizatriptan 10 milligrams as soon as you can tell a migraine is starting. The dissolving tablet melts on your tongue without water. If the headache improves and then comes back, you may take another 10 milligrams at least two hours later, but no more than 30 milligrams in 24 hours. If the first dose doesn’t help at all, don’t repeat it; tell us. If you take propranolol, use the 5-milligram dose, no more than three in 24 hours.

Drowsiness, dizziness, or pressure in the chest, throat or jaw can happen and usually isn’t a heart problem. Don’t drive until you know its effect. Severe or lasting chest pain, trouble breathing, or sudden weakness, numbness, trouble speaking or vision loss means call 911. Don’t take it within 24 hours of another triptan or an ergot medicine, and tell us about any antidepressants. Using it on 10 or more days a month can cause more headaches, so track your headache days.

Clinical reference

Dose options

Adult acute migraine

10 mg tablet or ODT at onset; may repeat ≥2 hours later if the headache returns; maximum 30 mg/24 h

5 mg is an alternative start (generic; Maxalt brand no longer markets 5 mg). Safety of treating >4 headaches per 30 days is not established. The ODT is not faster and contains phenylalanine.

With propranolol

5 mg per dose; maximum 3 doses (15 mg) per 24 h

Propranolol raises rizatriptan exposure about 70%.

Combination therapy (ACP 2025)

Add a triptan to an NSAID (strong recommendation) or acetaminophen (conditional) when either alone is inadequate; take early in the attack

Keep triptan use below 10 days/month to avoid medication-overuse headache; consider prevention for frequent or disabling attacks.

Before prescribing

Confirm migraine; contraindicated with ischemic or vasospastic CAD, stroke/TIA, PVD, ischemic bowel, uncontrolled HTN, hemiplegic or basilar migraine, MAO-A or nonselective MAOI within 2 weeks, or triptan/ergot within 24 h. Cardiac evaluation if multiple CV risk factors.

Side effects and return precautions

Somnolence, dizziness, fatigue, chest/throat/jaw pressure (usually noncardiac). Rare MI, arrhythmia, stroke, vasospasm, hypertensive crisis; serotonin syndrome with SSRIs/SNRIs. Watch acute-treatment days for medication overuse (≥10 days/month).

Follow-up

Review response and tolerability after 2–3 treated attacks using a headache and medication diary. If inadequate, consider NSAID combination, another triptan or another class; discuss prevention for frequent attacks.

Sources

Checked October 15, 2026.

Rosuvastatin (Crestor)Cholesterol lowering and cardiovascular prevention

What to say

We’re starting rosuvastatin 10 milligrams once a day to lower LDL, or bad cholesterol, and reduce future heart and stroke risk. Take it at a time you can remember, with or without food. You probably won’t feel a day-to-day change when it’s working.

Tell me about new persistent muscle aches so we can assess them and adjust the plan if needed. Severe muscle pain or weakness with dark urine means stop it and go to the emergency department. Check before adding prescriptions or supplements because some combinations need a different dose. If you become pregnant, stop it and contact us promptly unless your specialist has already given you a different pregnancy plan. We’ll repeat cholesterol in about four to twelve weeks.

Clinical reference

Dose options

Moderate intensity

5–10 mg orally once daily

Select dose from risk, desired LDL reduction, ancestry, renal function and interactions.

High intensity

20–40 mg once daily

Maximum 40 mg/day; individualize to LDL response and risk. Myopathy risk is greater at 40 mg.

Lower starting dose / renal limit

Asian patients: start 5 mg. CrCl <30 and not on hemodialysis: start 5 mg, maximum 10 mg daily

Interaction-specific limits may be lower. No routine mild/moderate renal adjustment.

Before prescribing

Check lipids, liver history, renal function, interacting drugs, pregnancy/breastfeeding and myopathy risks. Baseline liver enzymes as appropriate; no routine CK without a reason.

Side effects and return precautions

Muscle symptoms/GI effects; myopathy, liver injury and rare serious reactions. When using aluminum/magnesium antacids, take rosuvastatin at least two hours before the antacid.

Follow-up

Lipids 4–12 weeks after starting/changing, then periodic review. Investigate symptoms and adherence before escalation; liver enzymes when clinically indicated.

Sources

Checked September 20, 2026.

Sacubitril/valsartan (Entresto)Heart failure

What to say

Entresto eases the strain on your heart and lowers the chance of hospital stays and death from heart failure. Take [dose] twice a day, with or without food. If you take an ACE inhibitor such as lisinopril, take your last dose at least 36 hours before your first Entresto dose, and never take them together. Entresto contains valsartan, so don’t add losartan or similar pills. We’ll raise the dose every 2–4 weeks as your blood pressure and labs allow.

Dizziness is common at first, so stand up slowly. Call the same day if you feel faint or can’t drink normally because of vomiting or diarrhea. We’ll check kidney function and potassium 1–2 weeks after each change. Avoid potassium supplements, salt substitutes and ibuprofen-type pain relievers unless we approve them. Swelling of the lips, tongue or throat, or trouble breathing, means stop it and call 911. It can harm an unborn baby, so call us right away if you become pregnant.

Clinical reference

Dose options

HFrEF: usual adult start

49/51 mg twice daily; double every 2–4 weeks to target 97/103 mg twice daily

Start 24/26 mg twice daily if ACEi/ARB-naive or on low doses, eGFR <30 or Child-Pugh B. Not recommended in Child-Pugh C. Allow 36 hours after the last ACEi dose.

Older, frail, low BP or volume-depleted

Consider 24/26 mg twice daily with slower titration

Label: correct volume or salt depletion first or start lower. ACC 2024 pathway: adjust titration for older and frail patients.

  • The 2022 AHA/ACC/HFSA guideline prefers ARNi over ACEi or ARB in HFrEF and recommends switching patients who tolerate an ACEi or ARB.

Before prescribing

Confirm HFrEF; check BP, potassium, eGFR and pregnancy (boxed fetal-toxicity warning). Contraindicated: ACEi within 36 hours, prior ACEi/ARB angioedema, aliskiren with diabetes. Avoid with other ARBs or hereditary angioedema; angioedema is more common in Black patients. Check cost.

Side effects and return precautions

Hypotension, hyperkalemia, creatinine rise, cough and dizziness. Angioedema: stop permanently. BNP rises on therapy (neprilysin substrate); follow NT-proBNP. NSAIDs, potassium-sparing diuretics, potassium supplements and lithium interact. Breastfeeding not recommended.

Follow-up

BMP and BP 1–2 weeks after starting and each titration. A mild eGFR fall doesn’t automatically mean stopping. For symptomatic hypotension, adjust diuretics or other antihypertensives before reducing the dose.

Sources

Checked October 15, 2026.

Salicylic acid 17–40% (Compound W, Mediplast)Common warts

What to say

For this wart, use an over-the-counter salicylic acid product. First soak the wart in warm water for 5 minutes and dry it well. Every few days, gently sand the surface with a disposable emery board or pumice stone used only on the wart. Apply the liquid or gel to cover just the wart once or twice a day, or apply a 40% pad and change it every 48 hours. Continue for up to 12 weeks.

If the skin around it gets sore, stop for a few days, then restart. Don’t use it on your face, genitals, moles, or irritated or infected skin, or if you have diabetes or poor circulation. Keep it away from your eyes and flames. Call us if the wart bleeds or changes, or for spreading redness, swelling or pus. If it’s still there after 12 weeks, we can freeze it or try another treatment.

Clinical reference

Dose options

Common or plantar warts (OTC)

17% liquid or gel once or twice daily for up to 12 weeks, or 40% plaster changed every 48 hours for up to 12 weeks

Soak 5 minutes and dry first. Drug Facts: don’t use with diabetes or poor circulation, or on face, genitals, mucous membranes, moles or birthmarks.

Alternatives

Cryotherapy every 2–4 weeks; duct tape occlusion changed every 5–6 days

AAD notes mixed evidence for duct tape. Refer facial, genital, numerous or persistent warts and immunosuppressed patients.

Before prescribing

Confirm a common or plantar wart, not a corn, callus or skin cancer; bleeding or changing lesions need evaluation. Exclude diabetes, peripheral vascular disease, neuropathy and immunosuppression.

Side effects and return precautions

Local irritation, pain, maceration and skin discoloration. Stop for persistent discomfort (Mediplast: beyond 72 hours). Infection signs need review.

Follow-up

Reassess at 12 weeks or sooner for irritation. Many warts resolve on their own over months to years; offer cryotherapy or referral if persistent.

Sources

Checked October 15, 2026.

Scopolamine patch (Transderm Scop)Motion sickness

What to say

The scopolamine patch helps prevent motion sickness. Put one patch on clean, dry, hairless skin behind one ear at least 4 hours before you need it; the night before works well for a morning trip. It lasts 3 days; for a longer trip, replace it with a new patch behind the other ear. Don’t cut it, and wash your hands after touching it. It prevents symptoms but won’t treat them once they start.

Dry mouth, drowsiness and blurry vision are common. Don’t touch your eyes after handling it, avoid alcohol, and don’t drive until you know how it affects you. Remove it before an MRI. Take it off and call us the same day for confusion, hallucinations, trouble passing urine, overheating or not sweating in warm weather. For eye pain, redness or halos around lights, take it off and get urgent care. Dizziness or nausea can start a day or more after you remove it.

Clinical reference

Dose options

Motion sickness prevention

1 patch (1 mg released over 3 days) on the hairless skin behind one ear at least 4 hours before it is needed; if needed longer than 3 days, remove it and apply a new patch behind the other ear

One patch at a time; do not cut. CDC Yellow Book lists onset about 6–8 hours for the 1 mg patch and favors it for trips over 6 hours with moderate or greater motion, so applying the evening before departure is practical. If displaced, discard and apply a new one.

Special populations

Adults only; not studied in renal or hepatic impairment (monitor more often)

Not approved in children; the Yellow Book advises avoiding scopolamine in all children. Older adults have more confusion, hallucinations, dizziness and withdrawal symptoms.

  • Prescription only in the US. The patch absorbs slowly, so it prevents but does not treat motion sickness already under way (CDC Yellow Book).

Before prescribing

Contraindicated with angle-closure glaucoma or belladonna alkaloid allergy. Use caution with open-angle glaucoma, urinary retention, pyloric or intestinal obstruction, seizures, psychosis, pregnancy (avoid in severe preeclampsia), older age, and anticholinergic or sedating drugs.

Side effects and return precautions

Dry mouth, drowsiness, blurred vision, dilated pupils. Remove for confusion, hallucinations, urinary retention, eye pain or halos, or hyperthermia. Withdrawal (dizziness, nausea) can start 24 hours or more after removal.

Follow-up

Suggest a trial run before travel when feasible. Remove before MRI. Reassess if symptoms persist after removal or withdrawal is severe, and consider another antiemetic for future trips.

Sources

Checked October 15, 2026.

Semaglutide injection (Ozempic)Cardiovascular risk reduction in type 2 diabetes

What to say

We’re adding Ozempic to lower the chance of heart attack, stroke or cardiovascular death. Start the injection at 0.25 milligrams once weekly for four weeks, then follow the written increases. The low starting dose helps your stomach adjust. We’ll practice the injection and agree on follow-up. This adds to the rest of your diabetes and prevention plan.

Nausea, constipation or diarrhea can happen, especially after an increase. Call if you can’t keep fluids down, and don’t increase while side effects are troublesome. Stop and seek urgent care for severe persistent abdominal pain. Tell us about new vision changes, planned anesthesia or pregnancy plans. We’ll review other diabetes medicines to avoid low blood sugar. Don’t combine it with another semaglutide or GLP-1 medicine.

Clinical reference

Dose options

Cardiovascular risk reduction in type 2 diabetes

0.25 mg weekly for 4 weeks, then 0.5 mg weekly; subsequent increases depend on the prescribed glycemic plan

Adults with type 2 diabetes and established cardiovascular disease. The cardiovascular outcome trial used 0.5 or 1 mg weekly. A 2-mg dose is a glycemic escalation, not a requirement for cardiovascular benefit.

Before prescribing

Adults with type 2 diabetes and established cardiovascular disease. Check MTC/MEN2 history, pregnancy plans, severe gastroparesis, pancreatitis, retinopathy, insulin/sulfonylureas and other GLP-1 drugs. Review renal function and volume status; no routine renal dose reduction.

Side effects and return precautions

GI intolerance, dehydration, gallbladder/pancreatic symptoms and new vision changes need assessment. Pregnancy requires immediate review of the diabetes plan; stop at least two months before planned pregnancy. Tell the anesthesia team about use.

Follow-up

Review tolerance before every escalation, glucose when relevant, hydration and kidney function if GI illness occurs. Missed Ozempic dose: take within 5 days, otherwise skip. Stop at least two months before a planned pregnancy and contact the prescriber promptly if pregnancy occurs.

Sources

Checked September 23, 2026.

Semaglutide injection (Ozempic)Kidney protection in type 2 diabetes and CKD

What to say

We’re adding Ozempic to slow worsening kidney disease and lower the risk of serious kidney and heart complications. Start the injection at 0.25 milligrams once weekly for four weeks, then follow the written increases. The low starting dose helps your stomach adjust. We’ll practice the injection and agree on follow-up. This adds to the rest of your diabetes and prevention plan.

Nausea, constipation or diarrhea can happen, especially after an increase. Call if you can’t keep fluids down, and don’t increase while side effects are troublesome. Stop and seek urgent care for severe persistent abdominal pain. Tell us about new vision changes, planned anesthesia or pregnancy plans. We’ll review other diabetes medicines to avoid low blood sugar. Don’t combine it with another semaglutide or GLP-1 medicine.

Clinical reference

Dose options

Kidney protection in type 2 diabetes and CKD

0.25 mg weekly for 4 weeks, then 0.5 mg weekly for at least 4 weeks, then 1 mg weekly

Adults with both type 2 diabetes and chronic kidney disease. The kidney-outcome maintenance dose is 1 mg weekly; do not substitute the starter dose.

Before prescribing

Adults with both type 2 diabetes and chronic kidney disease. Check MTC/MEN2 history, pregnancy plans, severe gastroparesis, pancreatitis, retinopathy, insulin/sulfonylureas and other GLP-1 drugs. Review renal function and volume status; no routine renal dose reduction.

Side effects and return precautions

GI intolerance, dehydration, gallbladder/pancreatic symptoms and new vision changes need assessment. Pregnancy requires immediate review of the diabetes plan; stop at least two months before planned pregnancy. Tell the anesthesia team about use.

Follow-up

Review tolerance before every escalation, glucose when relevant, hydration and kidney function if GI illness occurs. Missed Ozempic dose: take within 5 days, otherwise skip. Stop at least two months before a planned pregnancy and contact the prescriber promptly if pregnancy occurs.

Sources

Checked September 23, 2026.

Semaglutide injection (Ozempic)Type 2 diabetes

What to say

To help lower your blood sugar, we’ll start Ozempic at 0.25 milligrams once a week for four weeks, then move to 0.5 milligrams if you’re tolerating it. The first dose is to help your body adjust. Choose a weekly day, and let’s have you demonstrate the pen before you use it at home.

Nausea, fullness, constipation or diarrhea can happen, especially after an increase. Smaller meals help. Call the same day if you can’t keep fluids down or are becoming dehydrated. Don’t increase while symptoms are troublesome. Severe persistent belly pain, with or without vomiting, means stop it and go to the emergency department. We’ll review your symptoms and blood sugars before increasing. Tell me about a personal or family history of medullary thyroid cancer or MEN2, an inherited condition, as well as pregnancy plans, and any upcoming anesthesia. We need to stop semaglutide at least two months before a planned pregnancy.

Clinical reference

Dose options

Ozempic: initiation

0.25 mg subcutaneously weekly ×4 weeks, then 0.5 mg weekly

For type 2 diabetes; 0.25 mg is an initiation dose.

Ozempic: escalation

If needed, 1 mg then 2 mg weekly after ≥4 weeks at each preceding dose

Maximum 2 mg weekly. The diabetes-with-CKD outcome indication specifies 1 mg after ≥4 weeks at 0.5 mg.

Before prescribing

Check product/indication, MTC/MEN2, pregnancy, pancreatitis/severe gastric-emptying history, retinopathy, glucose-lowering drugs and access. No routine renal/hepatic adjustment, but dehydration can cause kidney injury.

Side effects and return precautions

GI intolerance, dehydration, gallbladder/pancreatic symptoms and new vision changes need assessment. Pregnancy requires immediate review of the diabetes plan; stop at least two months before planned pregnancy. Tell the anesthesia team about use.

Follow-up

Review tolerance, intake and glucose before escalation. Missed dose: take within five days, otherwise skip. Longer interruptions may require retitration. Review hypoglycemia risk and possible insulin/sulfonylurea reduction.

Sources

Checked September 22, 2026.

Semaglutide injection (Wegovy)Cardiovascular risk reduction with overweight or obesity

What to say

We’re using Wegovy injections to lower the chance of another major cardiovascular event, alongside the food and activity plan. Start 0.25 milligrams once weekly for four weeks. We’ll increase slowly using your written schedule and check tolerance before each step. Keep taking the other heart-protection medicines in your plan.

Nausea, constipation or diarrhea can happen, especially after an increase. Call if you can’t keep fluids down, and don’t increase while side effects are troublesome. Stop and seek urgent care for severe persistent abdominal pain. Tell us about new vision changes, planned anesthesia or pregnancy plans. We’ll review other diabetes medicines to avoid low blood sugar. Don’t combine it with another semaglutide or GLP-1 medicine.

Clinical reference

Dose options

Injection escalation

0.25 → 0.5 → 1 → 1.7 mg once weekly, each for 4 weeks

Delay escalation if not tolerated; this is the injection schedule, not oral Wegovy.

Maintenance for this indication

2.4 mg once weekly recommended; 1.7 mg may be used if appropriate

Choose 2.4 or 1.7 mg based on response and tolerance. The 7.2-mg weight-management option is not the cardiovascular-risk-reduction maintenance schedule.

Before prescribing

Adults with established cardiovascular disease and overweight or obesity; diabetes is not required. Review MTC/MEN2, pregnancy, severe gastroparesis, pancreatitis, retinopathy, glucose-lowering drugs, other GLP-1 products and access.

Side effects and return precautions

GI intolerance, dehydration, gallbladder/pancreatic symptoms and new vision changes need assessment. Stop for pregnancy. Check glucose/hypoglycemia risk if diabetes treatment is also prescribed; no duplicate GLP-1/semaglutide products.

Follow-up

Review before dose increases and monitor the indication-specific outcomes with the treating team. For a missed dose, follow the injection product instructions; after multiple missed doses, contact the prescriber about restarting. Stop at least two months before planned pregnancy; contact the prescriber promptly if pregnancy occurs.

Sources

Checked September 23, 2026.

Semaglutide injection (Wegovy)MASH with moderate to advanced fibrosis

What to say

We’re using Wegovy injections to treat the liver inflammation and scarring from MASH, alongside the food and activity plan. Start 0.25 milligrams once weekly for four weeks. We’ll increase slowly using your written schedule and check tolerance before each step. Your liver team will also follow the liver disease. Feeling better or losing weight alone doesn’t show how much scarring has changed.

Nausea, constipation or diarrhea can happen, especially after an increase. Call if you can’t keep fluids down, and don’t increase while side effects are troublesome. Stop and seek urgent care for severe persistent abdominal pain. Tell us about new vision changes, planned anesthesia or pregnancy plans. We’ll review other diabetes medicines to avoid low blood sugar. Don’t combine it with another semaglutide or GLP-1 medicine.

Clinical reference

Dose options

Injection escalation

0.25 → 0.5 → 1 → 1.7 mg once weekly, each for 4 weeks

Delay escalation if not tolerated; this is the injection schedule, not oral Wegovy.

Maintenance for this indication

2.4 mg once weekly recommended; 1.7 mg may be used if appropriate

For MASH, if reduced to 1.7 mg for intolerance, consider re-escalation to 2.4 mg. Do not use the 7.2-mg weight-management schedule for this indication.

Before prescribing

Adults with noncirrhotic MASH and fibrosis consistent with F2–F3; confirm staging with the liver-care team. This is not a generic fatty-liver or cirrhosis indication. Review MTC/MEN2, pregnancy, severe gastroparesis, pancreatitis, retinopathy, glucose-lowering drugs, other GLP-1 products and access.

Side effects and return precautions

GI intolerance, dehydration, gallbladder/pancreatic symptoms and new vision changes need assessment. Stop for pregnancy. Check glucose/hypoglycemia risk if diabetes treatment is also prescribed; no duplicate GLP-1/semaglutide products.

Follow-up

Review before dose increases and monitor the indication-specific outcomes with the treating team. For a missed dose, follow the injection product instructions; after multiple missed doses, contact the prescriber about restarting. Stop at least two months before planned pregnancy; contact the prescriber promptly if pregnancy occurs. MASH approval is accelerated, based on histologic improvement; continued approval depends on confirmation of clinical benefit.

Sources

Checked September 23, 2026.

Semaglutide injection (Wegovy)Weight management

What to say

To help with weight management alongside food and activity changes, start Wegovy 0.25 milligrams once weekly for four weeks. We’ll increase gradually according to the written schedule, checking side effects before each increase. Let’s practice with your injection device. This is a long-term treatment. We’ll follow how it affects your health, function and weight.

Nausea, fullness, constipation or diarrhea are common early. Smaller meals may help. Call the same day if you can’t keep fluids down. Don’t increase while symptoms are troublesome. Severe persistent belly pain, with or without vomiting, means stop it and go to the emergency department. Tell us about thyroid cancer of the medullary type or MEN2 in you or your family, new vision changes, or planned anesthesia. Stop it and contact us if pregnant, and stop at least two months before a planned pregnancy.

Clinical reference

Dose options

Wegovy injection: weight reduction

0.25 → 0.5 → 1 → 1.7 mg weekly, each for 4 weeks; then 2.4 mg recommended maintenance (or 1.7 mg)

Delay an increase if not tolerated. Applies to the specified injection product/indication, not oral semaglutide.

Wegovy: higher dose

7.2 mg weekly may be considered after ≥4 weeks tolerating 2.4 mg if additional adult weight reduction is indicated

Per the June 2026 prescribing information; not a maximum for other indications. Confirm the exact product and device.

Before prescribing

Check product/indication, MTC/MEN2, pregnancy, pancreatitis/severe gastric-emptying history, retinopathy, glucose-lowering drugs and access. No routine renal/hepatic adjustment, but dehydration can cause kidney injury. Confirm adult weight-management eligibility and use the injection schedule, not the oral product schedule.

Side effects and return precautions

GI intolerance, dehydration, gallbladder/pancreatic symptoms and new vision changes need assessment. Stop for pregnancy. Check glucose/hypoglycemia risk if diabetes treatment is also prescribed; no duplicate GLP-1/semaglutide products.

Follow-up

Review intake, tolerance, weight and functional goals before escalation. For a missed injection, take only if the next dose is more than 48 hours away; otherwise seek product/pharmacist instructions at the 48-hour boundary or skip if closer. After two or more consecutive missed doses, restart escalation at a lower dose under the current label.

Sources

Checked September 22, 2026.

Semaglutide tablets (Ozempic pill, Rybelsus)Type 2 diabetes

What to say

For your type 2 diabetes, start the Ozempic pill (semaglutide): 1.5 milligrams daily for 30 days, then 4 milligrams, possibly 9 milligrams later. Take it on waking, on an empty stomach, with up to 4 ounces of plain water; swallow it whole. Wait at least 30 minutes before food, drinks or other pills. Take 1 tablet a day; skip a missed dose. Older Rybelsus tablets have different strengths; don’t mix them.

Nausea, fullness, diarrhea or constipation are common early; call the same day if you can’t keep fluids down. Severe belly pain that won’t go away, with or without vomiting, means stop it and go to the emergency department. We may lower insulin or glipizide-type pills and recheck thyroid levels if you take thyroid medicine. Tell us about medullary thyroid cancer or MEN2, an inherited condition, in you or your family, vision changes or upcoming anesthesia. Stop it 2 months before a planned pregnancy; don’t breastfeed while taking it.

Clinical reference

Dose options

Ozempic tablets (new formulation)

1.5 mg daily for days 1–30, then 4 mg daily; from day 61, 9 mg daily if more glycemic control is needed

1.5 mg is initiation only. Maximum 9 mg. Same regimen for MACE reduction (SOUL used Rybelsus 14 mg, exposure-matched to 9 mg). No renal or hepatic adjustment.

Rybelsus (original tablets) and switching

Rybelsus 3 mg for 30 days, then 7 mg, then 14 mg if needed. After day 30: Rybelsus 7 mg ↔ Ozempic tablets 4 mg; 14 mg ↔ 9 mg, starting the day after the last tablet

Not substitutable mg for mg; don’t switch during the 30-day initiation phase. Novo Nordisk is discontinuing all Rybelsus strengths in the US; switching needs a new prescription.

From Ozempic injection

From 0.5 mg weekly: start Ozempic tablets 4 or 9 mg (Rybelsus 7 or 14 mg) 1 week after the last injection

Not recommended in severe gastroparesis. Breastfeeding not recommended because of the SNAC absorption enhancer.

  • In the US, Novo Nordisk is discontinuing all Rybelsus strengths (wholesale shipments stopped May 2026); new starts use Ozempic tablets 1.5 mg. Wegovy tablets are a separate weight-management product; don’t combine semaglutide products.

Before prescribing

Confirm product and strength (Ozempic tablets, Rybelsus or Wegovy tablets) and a workable fasting morning routine. Check MTC/MEN2, pancreatitis, severe gastroparesis, retinopathy, pregnancy or breastfeeding, other GLP-1 RA or DPP-4 use, and levothyroxine.

Side effects and return precautions

GI effects and dehydration-related AKI; pancreatitis; gallbladder disease; retinopathy complications; hypoglycemia with insulin or sulfonylureas; hypersensitivity; rare NAION (ADA). Levothyroxine exposure rises about 33%, so check TSH. Tell anesthesia teams about use.

Follow-up

Review tolerance, the dosing routine and glucose at days 30 and 60; A1c in about 3 months. Reduce sulfonylurea or insulin as glucose falls. Stop ≥2 months before a planned pregnancy (long washout).

Sources

Checked October 15, 2026.

Semaglutide tablets (Wegovy pill)Weight management

What to say

For weight management alongside food and activity changes, take 1 Wegovy pill each morning on an empty stomach with up to 4 ounces of plain water. Swallow it whole, then wait at least 30 minutes before eating, drinking or taking other pills. Take 1.5 milligrams for 30 days, then 4 and 9 milligrams for 30 days each, then 25 milligrams daily. If you miss a dose, skip it. Ask us about the current cost.

Nausea, diarrhea, vomiting or constipation are common early. Call the same day if you can’t keep fluids down. Severe belly pain that won’t go away means stop it and go to the emergency department. Tell us about medullary thyroid cancer or MEN2 in you or your family, a neck lump, planned anesthesia, or insulin or sulfonylureas. If you take levothyroxine, we’ll recheck your thyroid levels. Don’t breastfeed while taking it. Stop it 2 months before trying to get pregnant, or right away if you become pregnant.

Clinical reference

Dose options

Wegovy tablets: weight or CV risk reduction

1.5 mg daily days 1–30 → 4 mg days 31–60 → 9 mg days 61–90 → 25 mg daily maintenance

Delay escalation if not tolerated; if 25 mg isn’t tolerated, consider Wegovy injection 1.7 mg weekly. One tablet daily. Missed dose: skip.

Administration

On waking, empty stomach, ≤4 oz plain water; wait ≥30 minutes before food, drink or other oral medicines

Swallow whole; store in the original bottle. Strengths differ from Rybelsus; don’t substitute mg-for-mg or combine semaglutide products.

Switching from Wegovy injection

2.4 mg weekly → 25 mg tablet daily, starting 1 week after the last injection

Tablet to injection: start 2.4 mg weekly the day after the last 25 mg tablet (1.7 mg if 25 mg wasn’t tolerated).

  • Approved December 22, 2025. Same Wegovy label as the injection, with daily dosing and different strengths; it is not the Rybelsus or Ozempic tablet used for diabetes.

Before prescribing

Confirm adult eligibility and product. Contraindicated with personal or family MTC or MEN2. Review pregnancy plans, breastfeeding, pancreatitis, gallbladder disease, severe gastroparesis, retinopathy, insulin or sulfonylureas, levothyroxine (exposure +33%) and other GLP-1 products.

Side effects and return precautions

GI effects, dehydration and AKI, pancreatitis, gallbladder disease, hypoglycemia with insulin or sulfonylureas, heart-rate increase, dysesthesia, hypersensitivity and aspiration risk with anesthesia or deep sedation.

Follow-up

Review tolerance before each step and weight after 3 months on 25 mg. Recheck TSH on levothyroxine. Not studied for weight loss in type 2 diabetes (lower exposure); consider the injection if response is poor.

Sources

Checked October 15, 2026.

Senna (Senokot)Constipation

What to say

Senna is a stimulant laxative that prompts the bowel to move, usually within 6–12 hours, so take it at bedtime. Start with one or two 8.6-milligram tablets. If that isn’t enough after a few days, we can raise the dose, up to the label maximum of four tablets twice a day. We may pair it with a softening laxative such as polyethylene glycol. If you take opioid pain medicine, take senna regularly as planned, not just once you’re blocked up.

Cramping, belly discomfort or loose stools can happen, especially at higher doses. The label limits self-treatment to 1 week; longer regular use can be reasonable, but we’ll plan it together. Check with us first if you have belly pain, nausea or vomiting, or could be pregnant. Call us for rectal bleeding, black stools, unplanned weight loss, or no bowel movement after taking it. Severe belly pain or swelling with vomiting, or not passing gas, means go to the emergency department.

Clinical reference

Dose options

Adult dose

Sennosides 8.6–17.2 mg (1–2 tablets) once daily, preferably at bedtime

Drug Facts start dose is 17.2 mg; AGA/ACG 2023 suggests starting low and increasing only if there is no response. Bowel movement usually follows in 6–12 hours.

Maximum

34.4 mg (4 tablets) twice daily

Drug Facts maximum and the often-cited ceiling in the AGA/ACG dosing table. Cramping rises with dose. OTC labeling limits use to 1 week unless a clinician directs longer use.

Stimulant alternative: bisacodyl

5 mg once daily, up to 10 mg (AGA/ACG table); Drug Facts allows 5–15 mg once daily

AGA/ACG 2023 strongly recommends it for short-term (≤4 weeks of daily use) or rescue therapy. Swallow whole; don’t take within 1 hour after an antacid or milk.

  • Senna trials lasted 4 weeks; AGA/ACG 2023 considers longer use probably appropriate, but long-term safety data are limited.

Before prescribing

Assess alarm features (bleeding, iron deficiency, weight loss), obstruction or impaction, and constipating drugs such as opioids, anticholinergics and iron. AGA/ACG advises against sennosides in pregnancy. For opioid-induced constipation, laxatives are first line.

Side effects and return precautions

Cramping, abdominal pain and diarrhea are dose related; excessive stimulant use can cause dehydration and electrolyte imbalance. Obstructive symptoms or rectal bleeding need prompt assessment.

Follow-up

Review stool frequency, form and cramping in 1–2 weeks; adjust or combine with PEG or fiber. If OTC agents fail, consider linaclotide, plecanatide, lubiprostone or prucalopride, or evaluation for a defecation disorder.

Sources

Checked October 15, 2026.

Sertraline (Zoloft)Depression

What to say

For depression, start sertraline 50 milligrams once daily, with or without food. Take it regularly. We’ll follow your mood and daily functioning over the coming weeks. Sleep or appetite may improve before the full mood benefit.

Early nausea, loose stools or changes in sleep can settle, but tell me if they’re making treatment difficult. Sexual side effects can also happen. We have options if that becomes a problem. We’ll arrange an early check-in and then review the benefit over the next several weeks. Call the same day for worsening thoughts of self-harm, marked agitation or unusually high energy with very little sleep. If you might act on those thoughts, call 911. 988 can provide crisis support. Don’t stop abruptly or add other mood or cough medicines without checking for interactions.

Clinical reference

Dose options

Adult depression

50 mg orally daily

Increase subsequent doses by 25–50 mg no more often than weekly according to response; maximum 200 mg/day.

Titration / maximum

Increase by 25–50 mg no more often than weekly; maximum 200 mg/day

Mild hepatic impairment: halve start/range. Moderate/severe hepatic impairment: not recommended. No renal adjustment.

Before prescribing

Assess suicidality, bipolar/mania history, interactions/MAOIs and hepatic function. Review pregnancy, bleeding risk and hyponatremia risk, especially older/diuretic users.

Side effects and return precautions

GI, sleep and sexual effects; watch for activation/mania, suicidality, bleeding and serotonin syndrome. Fever with agitation/confusion and rigidity needs emergency assessment.

Follow-up

Review generally within two weeks; one week at ages 18–25 or increased suicide risk, sooner if needed. Reassess efficacy over weeks; discuss continuation after remission and taper when stopping. Track mood and function.

Sources

Checked September 22, 2026.

Sertraline (Zoloft)Obsessive-compulsive disorder

What to say

For OCD, start sertraline 50 milligrams once daily, with or without food. We’ll track how much time intrusive thoughts and rituals take and how they affect your day. It works gradually. Take it daily and continue the therapy plan we’ve discussed.

Early nausea, loose stools or changes in sleep can settle, but tell me if they’re making treatment difficult. Sexual side effects can also happen. We have options if that becomes a problem. We’ll arrange an early check-in and then review the benefit over the next several weeks. Call the same day for worsening thoughts of self-harm, marked agitation or unusually high energy with very little sleep. If you might act on those thoughts, call 911. 988 can provide crisis support. Don’t stop abruptly or add other mood or cough medicines without checking for interactions.

Clinical reference

Dose options

Adult obsessive-compulsive disorder

50 mg orally daily

Increase subsequent doses by 25–50 mg no more often than weekly according to response; maximum 200 mg/day.

Titration / maximum

Increase by 25–50 mg no more often than weekly; maximum 200 mg/day

Mild hepatic impairment: halve start/range. Moderate/severe hepatic impairment: not recommended. No renal adjustment.

Before prescribing

Assess suicidality, bipolar/mania history, interactions/MAOIs and hepatic function. Review pregnancy, bleeding risk and hyponatremia risk, especially older/diuretic users.

Side effects and return precautions

GI, sleep and sexual effects; watch for activation/mania, suicidality, bleeding and serotonin syndrome. Fever with agitation/confusion and rigidity needs emergency assessment.

Follow-up

Review generally within two weeks; one week at ages 18–25 or increased suicide risk, sooner if needed. Reassess efficacy over weeks; discuss continuation after remission and taper when stopping. Track obsession/compulsion burden and function.

Sources

Checked September 22, 2026.

Sertraline (Zoloft)Panic disorder

What to say

For panic disorder, start sertraline 25 milligrams once daily for one week, then 50 milligrams daily if tolerated. Starting low can help with early side effects. This is daily prevention, not a medicine to stop an attack immediately. We’ll track attacks, avoidance and everyday function.

Early nausea, loose stools or changes in sleep can settle, but tell me if they’re making treatment difficult. Sexual side effects can also happen. We have options if that becomes a problem. We’ll arrange an early check-in and then review the benefit over the next several weeks. Call the same day for worsening thoughts of self-harm, marked agitation or unusually high energy with very little sleep. If you might act on those thoughts, call 911. 988 can provide crisis support. Don’t stop abruptly or add other mood or cough medicines without checking for interactions.

Clinical reference

Dose options

Adult panic disorder

25 mg orally daily; increase to 50 mg after one week if tolerated

Increase subsequent doses by 25–50 mg no more often than weekly according to response; maximum 200 mg/day.

Titration / maximum

Increase by 25–50 mg no more often than weekly; maximum 200 mg/day

Mild hepatic impairment: halve start/range. Moderate/severe hepatic impairment: not recommended. No renal adjustment.

Before prescribing

Assess suicidality, bipolar/mania history, interactions/MAOIs and hepatic function. Review pregnancy, bleeding risk and hyponatremia risk, especially older/diuretic users.

Side effects and return precautions

GI, sleep and sexual effects; watch for activation/mania, suicidality, bleeding and serotonin syndrome. Fever with agitation/confusion and rigidity needs emergency assessment.

Follow-up

Review generally within two weeks; one week at ages 18–25 or increased suicide risk, sooner if needed. Reassess efficacy over weeks; discuss continuation after remission and taper when stopping. Track panic frequency and avoidance.

Sources

Checked September 22, 2026.

Sertraline (Zoloft)Post-traumatic stress disorder

What to say

For PTSD, start sertraline 25 milligrams once daily for one week, then 50 milligrams daily if tolerated. It may reduce symptoms such as feeling constantly on guard, intrusive memories and avoidance over time. We’ll review what matters most to you and how medication fits with your therapy plan.

Early nausea, loose stools or changes in sleep can settle, but tell me if they’re making treatment difficult. Sexual side effects can also happen. We have options if that becomes a problem. We’ll arrange an early check-in and then review the benefit over the next several weeks. Call the same day for worsening thoughts of self-harm, marked agitation or unusually high energy with very little sleep. If you might act on those thoughts, call 911. 988 can provide crisis support. Don’t stop abruptly or add other mood or cough medicines without checking for interactions.

Clinical reference

Dose options

Adult post-traumatic stress disorder

25 mg orally daily; increase to 50 mg after one week if tolerated

Increase subsequent doses by 25–50 mg no more often than weekly according to response; maximum 200 mg/day.

Titration / maximum

Increase by 25–50 mg no more often than weekly; maximum 200 mg/day

Mild hepatic impairment: halve start/range. Moderate/severe hepatic impairment: not recommended. No renal adjustment.

Before prescribing

Assess suicidality, bipolar/mania history, interactions/MAOIs and hepatic function. Review pregnancy, bleeding risk and hyponatremia risk, especially older/diuretic users.

Side effects and return precautions

GI, sleep and sexual effects; watch for activation/mania, suicidality, bleeding and serotonin syndrome. Fever with agitation/confusion and rigidity needs emergency assessment.

Follow-up

Review generally within two weeks; one week at ages 18–25 or increased suicide risk, sooner if needed. Reassess efficacy over weeks; discuss continuation after remission and taper when stopping. Track trauma symptoms, sleep and function.

Sources

Checked September 22, 2026.

Sertraline (Zoloft)Premenstrual dysphoric disorder (PMDD), daily dosing

What to say

For the severe mood symptoms tied to your menstrual cycle, take sertraline 50 milligrams once daily, every day throughout the month. We’ll write the schedule down and track symptoms across your cycles. This plan is for PMDD. Tell us if symptoms are present throughout the month too.

Nausea, loose stools, sleep changes or sexual side effects can occur. Contact us promptly for marked agitation, unusually high energy with little sleep or worsening thoughts of self-harm. Call 911 if you can’t stay safe. Don’t change the cycle schedule or add other mood medicines without checking with us.

Clinical reference

Dose options

Premenstrual dysphoric disorder (PMDD), daily dosing

50 mg once daily continuously

If needed, increase by 50 mg/day per menstrual cycle; maximum 150 mg/day, not the 200-mg depression maximum.

Hepatic function

Mild impairment: halve starting and maximum doses; moderate/severe impairment: not recommended

No renal dose adjustment.

Before prescribing

Confirm PMDD with prospective daily symptom tracking over at least two cycles where feasible; distinguish premenstrual worsening of another disorder. Check bipolar/suicide risk, interactions/MAOIs, hepatic disease, sodium/bleeding risk and pregnancy plans.

Side effects and return precautions

GI, sleep and sexual effects; watch for activation/mania, suicidality, bleeding and serotonin syndrome. Fever with agitation/confusion and rigidity needs emergency assessment.

Follow-up

Arrange an early safety review, then assess daily symptom records after each of the first few cycles. Reconfirm calendar dates for intermittent treatment; do not apply the depression titration or maximum.

Sources

Checked September 23, 2026.

Sertraline (Zoloft)Premenstrual dysphoric disorder (PMDD), luteal-phase dosing

What to say

For the severe mood symptoms tied to your menstrual cycle, take sertraline 50 milligrams once daily, starting 14 days before your expected period and continuing through the start of bleeding, then stop until the next planned cycle. We’ll write the schedule down and track symptoms across your cycles. This plan is for PMDD. Tell us if symptoms are present throughout the month too.

Nausea, loose stools, sleep changes or sexual side effects can occur. Contact us promptly for marked agitation, unusually high energy with little sleep or worsening thoughts of self-harm. Call 911 if you can’t stay safe. Don’t change the cycle schedule or add other mood medicines without checking with us.

Clinical reference

Dose options

Premenstrual dysphoric disorder (PMDD), luteal-phase dosing

50 mg once daily during the luteal phase: begin 14 days before expected menses through onset of menses

If needed in later cycles: maximum 100 mg/day; when increasing, use 50 mg for the first 3 treatment days, then 100 mg for the remaining treatment days.

Hepatic function

Mild impairment: halve starting and maximum doses; moderate/severe impairment: not recommended

No renal dose adjustment.

Before prescribing

Confirm PMDD with prospective daily symptom tracking over at least two cycles where feasible; distinguish premenstrual worsening of another disorder. Check bipolar/suicide risk, interactions/MAOIs, hepatic disease, sodium/bleeding risk and pregnancy plans.

Side effects and return precautions

GI, sleep and sexual effects; watch for activation/mania, suicidality, bleeding and serotonin syndrome. Fever with agitation/confusion and rigidity needs emergency assessment.

Follow-up

Arrange an early safety review, then assess daily symptom records after each of the first few cycles. Reconfirm calendar dates for intermittent treatment; do not apply the depression titration or maximum.

Sources

Checked September 23, 2026.

Sertraline (Zoloft)Social anxiety disorder

What to say

For social anxiety, start sertraline 25 milligrams once daily for one week, then 50 milligrams daily if tolerated. Take it every day rather than just before a social situation. We’ll judge progress by how much anxiety and avoidance interfere with the activities you want to do.

Early nausea, loose stools or changes in sleep can settle, but tell me if they’re making treatment difficult. Sexual side effects can also happen. We have options if that becomes a problem. We’ll arrange an early check-in and then review the benefit over the next several weeks. Call the same day for worsening thoughts of self-harm, marked agitation or unusually high energy with very little sleep. If you might act on those thoughts, call 911. 988 can provide crisis support. Don’t stop abruptly or add other mood or cough medicines without checking for interactions.

Clinical reference

Dose options

Adult social anxiety disorder

25 mg orally daily; increase to 50 mg after one week if tolerated

Increase subsequent doses by 25–50 mg no more often than weekly according to response; maximum 200 mg/day.

Titration / maximum

Increase by 25–50 mg no more often than weekly; maximum 200 mg/day

Mild hepatic impairment: halve start/range. Moderate/severe hepatic impairment: not recommended. No renal adjustment.

Before prescribing

Assess suicidality, bipolar/mania history, interactions/MAOIs and hepatic function. Review pregnancy, bleeding risk and hyponatremia risk, especially older/diuretic users.

Side effects and return precautions

GI, sleep and sexual effects; watch for activation/mania, suicidality, bleeding and serotonin syndrome. Fever with agitation/confusion and rigidity needs emergency assessment.

Follow-up

Review generally within two weeks; one week at ages 18–25 or increased suicide risk, sooner if needed. Reassess efficacy over weeks; discuss continuation after remission and taper when stopping. Track social avoidance and participation.

Sources

Checked September 22, 2026.

Sildenafil (Viagra)Erectile dysfunction

What to say

For erectile dysfunction, try sildenafil 50 milligrams about an hour before sexual activity. Sexual stimulation is still needed. Don’t take it more than once in a day. A heavy meal can make it work more slowly.

Headache, flushing, a stuffy nose or indigestion can happen. Never combine it with nitroglycerin, other nitrates or poppers. If you have chest pain after taking it, call 911, tell the team when you took sildenafil, and don’t take a nitrate yourself. An erection lasting four hours means go to the emergency department. For sudden loss of vision or hearing, stop it and go to the emergency department. We’ll review benefit and side effects before changing the dose.

Clinical reference

Dose options

Erectile dysfunction

50 mg orally as needed about 1 hour before sex; may take 30 minutes to 4 hours beforehand

Adjust to 25–100 mg based on benefit/tolerance; maximum once daily. Not the pulmonary-hypertension regimen.

Lower starting dose

Consider 25 mg if >65 years, hepatic impairment or CrCl <30 mL/min

When taking an alpha blocker, first ensure hemodynamic stability, then start 25 mg.

Interactions

Ritonavir: maximum 25 mg within 48 hours; other strong CYP3A4 inhibitors may require 25-mg initiation

Nitrates/nitrites and riociguat are contraindicated. Avoid combining with other PDE5 inhibitors.

Before prescribing

Assess cardiovascular safety of sexual activity, nitrate/nitrite/riociguat use, alpha blockers, renal/hepatic function and interacting drugs. Consider causes of ED and prior ischemic eye disease; review priapism risks.

Side effects and return precautions

Headache, flushing, dyspepsia, nasal congestion and visual changes; hypotension, priapism and sudden vision/hearing loss. Nitrates are generally avoided for at least 24 hours after sildenafil; timing does not authorize self-administration, and clearance may be delayed.

Follow-up

Review after several properly timed attempts or within a few weeks, including tolerability and interaction safety. Investigate nonresponse before dose escalation.

Sources

Checked September 20, 2026.

Simvastatin (Zocor)Cholesterol lowering and cardiovascular prevention

What to say

We’re starting simvastatin 20 milligrams every evening to lower cholesterol and reduce your chance of a heart attack or stroke. Take it each day, with or without food. You usually won’t feel it working. We’ll use your cholesterol results to see the effect.

Tell us about new muscle aches. Stop it and go to the emergency department for severe muscle pain or weakness, especially with dark urine. Check with us before starting a new medicine, including antibiotics or Paxlovid, because some combinations are unsafe. Avoid grapefruit juice. Stop and contact us promptly if you become pregnant. Tell us before trying to conceive so we can reassess treatment. We’ll recheck cholesterol in about six weeks and adjust the plan if needed.

Clinical reference

Dose options

Usual adult treatment

20–40 mg orally each evening

Maximum recommended new-treatment dose is 40 mg/day; use a different regimen if high-intensity treatment is needed.

Interaction limits

Maximum 10 mg/day with verapamil, diltiazem or dronedarone; 20 mg/day with amlodipine, amiodarone or ranolazine

Strong CYP3A4 inhibitors and several other combinations are contraindicated; perform a full interaction check.

Severe renal impairment

Start 5 mg each evening when CrCl is 15–29 mL/min

Use an available generic strength. Do not newly start 80 mg; that dose is restricted to established long-term tolerant users.

Before prescribing

Confirm indication/intensity, medication interactions, baseline liver enzymes and pregnancy plans. Avoid acute liver failure or decompensated cirrhosis.

Side effects and return precautions

Myalgia, rare rhabdomyolysis or liver injury; new unexplained muscle symptoms merit assessment.

Follow-up

Recheck lipid response in 4–12 weeks after starting/changing treatment; investigate symptoms rather than routinely checking CK in everyone.

Sources

Checked September 20, 2026.

Sitagliptin (Januvia)Type 2 diabetes

What to say

Sitagliptin helps your body release more insulin after meals, which lowers blood sugar. Take 100 milligrams once a day, with or without food. If your kidney function is reduced, we’ll use 50 or 25 milligrams instead. It doesn’t cause weight gain, and on its own it rarely causes low blood sugar. Unlike some newer diabetes medicines, it doesn’t protect the heart or kidneys. Generic sitagliptin is now available and usually costs less.

If you also take insulin or glipizide, watch for low blood sugar, like shakiness, sweating or confusion; treat it with fast sugar and tell us. Stop it and go to the emergency department for severe belly pain that spreads to your back, with or without vomiting. Call us for blisters, severe joint pain, or new swelling or breathlessness. Call 911 for swelling of your face, lips or tongue, or trouble breathing.

Clinical reference

Dose options

Type 2 diabetes

100 mg orally once daily

Monotherapy or add-on (e.g., to metformin). Modest A1C lowering; weight neutral; CV-neutral in TECOS.

Renal dosing

eGFR 30–<45: 50 mg daily. eGFR <30 or dialysis: 25 mg daily

Check eGFR before starting and periodically. May be given without regard to dialysis timing.

  • Generic sitagliptin tablets (ANDA products, e.g., Sandoz, Teva) have been marketed since 2026.

Before prescribing

Type 2 diabetes only. Ask about pancreatitis, heart failure, renal function and insulin or sulfonylurea use (lower those doses to limit hypoglycemia). Prior serious hypersensitivity contraindicates. Prefer GLP-1 RA or SGLT2 inhibitor with ASCVD, HF or CKD.

Side effects and return precautions

Pancreatitis, hypersensitivity (anaphylaxis, angioedema, SJS), bullous pemphigoid, severe arthralgia, acute kidney injury, heart failure; hypoglycemia with insulin or sulfonylureas.

Follow-up

A1C in about 3 months. If not at goal, add or switch rather than continue indefinitely. Don’t combine with a GLP-1 RA: no added glucose lowering (ADA 2026).

Sources

Checked October 15, 2026.

Sofosbuvir/velpatasvir (Epclusa)Hepatitis C

What to say

Epclusa cures hepatitis C in most people who finish it. Take one tablet once a day, with or without food, for 12 weeks. Try not to miss doses, and refill early. About 12 weeks after your last tablet, a blood test will confirm whether the virus is gone. Cure doesn’t protect you from getting hepatitis C again.

Headache, tiredness and nausea are usually mild. Check with us before starting any new medicine or supplement, because some stop Epclusa from working. Take antacids at least four hours apart from it, and don’t take omeprazole-type heartburn pills unless we’ve made a plan. If you take amiodarone, tell us now, because a dangerously slow heartbeat can happen. If you take diabetes medicine or warfarin, check your sugar or INR more often. Tell us if you’re pregnant. Call the same day for yellow eyes, dark urine or belly swelling. Fainting or chest pain means call 911.

Clinical reference

Dose options

Chronic HCV, treatment-naive adults (AASLD/IDSA simplified treatment)

1 tablet (sofosbuvir 400 mg/velpatasvir 100 mg) orally once daily for 12 weeks, with or without food

For no cirrhosis or compensated cirrhosis. Genotype 3 with cirrhosis needs baseline NS5A RAS testing; if Y93H is present, follow full guidance. No renal or hepatic dose adjustment, including dialysis.

Acid-reducing drugs

Antacids: separate by 4 hours. H2 blockers: at the same time or 12 hours apart, up to the equivalent of famotidine 40 mg twice daily. PPIs: not recommended

If a PPI is essential, give Epclusa with food 4 hours before omeprazole 20 mg; other PPIs have not been studied.

Decompensated cirrhosis (Child-Pugh B or C)

Epclusa plus weight-based ribavirin for 12 weeks

Outside the simplified pathway; manage with hepatology.

  • The AASLD/IDSA simplified pathway excludes prior HCV treatment, decompensated cirrhosis, HBsAg positivity, pregnancy, known or suspected HCC and liver transplant; follow full guidance or refer.

Before prescribing

Confirm HCV RNA, treatment history and cirrhosis status (FIB-4 >3.25 presumes cirrhosis). Test HBsAg and anti-HBc (boxed warning), HIV and pregnancy. Interactions: amiodarone, PPIs, rifamycins, carbamazepine, phenytoin, St John’s wort, efavirenz, rosuvastatin >10 mg, digoxin.

Side effects and return precautions

Headache, fatigue, nausea. Symptomatic bradycardia with amiodarone (hours to 2 weeks), HBV reactivation or flare, and hypoglycemia on diabetes drugs or INR shifts on warfarin as HCV clears; rare rash or angioedema.

Follow-up

HCV RNA and hepatic panel 12 or more weeks after completion; no routine on-treatment labs. Cirrhosis: HCC ultrasound every 6 months and variceal surveillance continue after cure. Ongoing risk: yearly HCV RNA.

Sources

Checked October 15, 2026.

Spironolactone (Aldactone)Acne, off-label

What to say

For your acne, we’ll start spironolactone 50 milligrams once daily. It reduces the effect of hormones on the skin. This use is off-label, meaning the drug is approved for other conditions but also has evidence for acne. Keep using the skin treatments we agreed on. We’ll review at six weeks before deciding whether to increase to 100 milligrams. Judge improvement over several months.

You may notice more urination, dizziness, breast tenderness or changes in your periods. Tell us if these are troublesome. Avoid pregnancy while taking it, and stop and contact us if you become pregnant. Don’t add potassium supplements or salt substitutes without checking. Let’s know about vomiting, poor fluid intake or new medicines, especially antibiotics. We’ll decide on blood tests from your kidney health and other risk factors.

Clinical reference

Dose options

Adult acne: SAFA trial regimen

50 mg orally daily for six weeks, then 100 mg daily if tolerated

Off-label use studied in adult women; individualize and allow 3–6 months to assess benefit.

Before prescribing

Review pregnancy possibility and prevention, renal disease, hyperkalemia, Addison disease, BP and potassium-raising drugs, including ACE/ARB, TMP/SMX and supplements. Assess baseline renal/potassium risk before choosing the monitoring plan.

Side effects and return precautions

Dizziness, menstrual irregularity, breast tenderness and increased urination. Hyperkalemia risk rises with kidney disease and interacting medicines; marked weakness or palpitations needs prompt assessment. Avoid pregnancy because of antiandrogenic fetal risk.

Follow-up

Review tolerance around six weeks and acne response at 3–6 months. AAD does not require routine potassium monitoring in healthy patients; monitor patients with older age, relevant illness or interacting medicines, including early testing after starting or increasing the dose.

Sources

Checked September 22, 2026.

Spironolactone (Aldactone)Heart failure

What to say

For your heart-failure plan, we’re adding spironolactone 25 milligrams once a day. It helps block a hormone that causes salt retention and contributes to strain on the heart. Choose whether to take it with food or without food, and use the same routine each day.

The main thing we need to monitor is potassium, which can rise without symptoms. We’ll check potassium and kidney function within a week and arrange the next check from those results. Don’t add potassium supplements, potassium salt substitutes or ibuprofen without checking. Dizziness, breast tenderness or breast enlargement can happen. Call the same day if you can’t drink normally, pee much less, or develop marked weakness or a racing heartbeat. Fainting or severe chest or breathing symptoms means call 911.

Clinical reference

Dose options

HFrEF, eGFR >50 and potassium ≤5.0 in label

25 mg orally once daily; may increase to 50 mg daily if tolerated

Guideline initiation requires eGFR >30 and potassium <5.0 mEq/L. If hyperkalemia occurs on 25 mg daily, dose reduction/holding depends on severity.

HFrEF, eGFR 30–50

Consider 25 mg every other day

Closer potassium/renal monitoring; do not start if eGFR ≤30 under the cited HF guideline.

Before prescribing

Check potassium/eGFR, volume status, pregnancy, Addison disease, other potassium-raising drugs and eplerenone. Avoid in hyperkalemia. Review ACE/ARB/ARNI combinations and TMP/SMX carefully.

Side effects and return precautions

Hyperkalemia/renal dysfunction, dizziness, menstrual effects and breast symptoms. Severe potassium abnormalities may be asymptomatic; have a reliable lab-response process.

Follow-up

Potassium within one week of initiation/titration and regularly thereafter, with renal/volume assessment. Schedule earlier/more frequent checks for high-risk combinations and an early clinical review.

Sources

Checked September 22, 2026.

Spironolactone (Aldactone)Hypertension

What to say

We’re adding spironolactone 25 milligrams once daily to help lower your blood pressure. Keep a record of home readings so we can judge the effect. Choose whether to take it with food or without food, and keep that routine each day.

The main thing we need to monitor is potassium, which can rise without symptoms. We’ll check potassium and kidney function within a week and arrange the next check from those results. Don’t add potassium supplements, potassium salt substitutes or ibuprofen without checking. Dizziness, breast tenderness or breast enlargement can happen. Call the same day if you can’t drink normally, pee much less, or develop marked weakness or a racing heartbeat. Fainting or severe chest or breathing symptoms means call 911.

Clinical reference

Dose options

Add-on hypertension treatment

25–100 mg/day, once daily or divided

The wording above starts at 25 mg daily. Titrate at intervals of at least two weeks; doses above 100 mg/day generally do not add BP reduction.

Before prescribing

Check potassium/eGFR, volume status, pregnancy, Addison disease, other potassium-raising drugs and eplerenone. Avoid in hyperkalemia. Review ACE/ARB/ARNI combinations and TMP/SMX carefully.

Side effects and return precautions

Hyperkalemia/renal dysfunction, dizziness, menstrual effects and breast symptoms. Severe potassium abnormalities may be asymptomatic; have a reliable lab-response process.

Follow-up

Potassium within one week of initiation/titration and regularly thereafter, with renal/volume assessment. Schedule earlier/more frequent checks for high-risk combinations and an early clinical review.

Sources

Checked September 22, 2026.

Sumatriptan tablets (Imitrex)Acute migraine

What to say

Take sumatriptan 50 milligrams when the migraine headache starts. If it helps but the headache comes back or only partly improves, you may repeat 50 milligrams after at least two hours. Under this prescription, don’t take more than two 50-milligram doses in twenty-four hours. If the first dose gives no relief, contact us before repeating it.

Tingling, warmth or dizziness can happen. New or severe chest pressure, trouble breathing, weakness or trouble speaking means call 911. Don’t assume it’s just migraine or a medicine effect. Don’t use another triptan or an ergot migraine medicine within twenty-four hours. Keep track of headache days and treatment days. We’ll review after you’ve tried it for a few attacks. Frequent use means we should discuss prevention. Your treatment-day limit is [days per month]. Contact us if you need more.

Clinical reference

Dose options

Oral acute migraine dose

25, 50 or 100 mg once; a second dose may be taken ≥2 hours later after some initial response

The wording above uses 50 mg with one 50-mg repeat, below the label maximum.

Label ceiling

Maximum 200 mg in 24 hours

Not prevention. Safety of treating an average of >4 headaches in 30 days is not established in the label; reassess frequent attacks.

Hepatic / medication-overuse limits

Mild/moderate hepatic impairment: maximum single dose 50 mg; severe hepatic impairment contraindicates use

Triptan use on ≥10 days/month can contribute to medication-overuse headache; set a practical limit and prevention review.

Before prescribing

Confirm migraine diagnosis and assess vascular disease/stroke/TIA, uncontrolled hypertension, hemiplegic/brainstem-aura migraine, ischemic bowel, MAO-A inhibitors and recent triptan/ergot. Multiple cardiovascular risks may require evaluation before first use.

Side effects and return precautions

Paresthesias/flushing/dizziness; vasospasm, ischemia, arrhythmia and serotonin syndrome. New neurologic or concerning chest symptoms require emergency assessment rather than repeat dosing.

Follow-up

Review response and tolerability after several attacks within a defined interval; keep headache/medication diary and discuss prevention if frequent/disabling.

Sources

Checked September 20, 2026.

Suvorexant (Belsomra)Insomnia

What to say

For insomnia, we’re using suvorexant alongside your sleep plan, including cognitive behavioral therapy for insomnia. Take 10 milligrams no more than once a night, within 30 minutes of going to bed, and only when you have at least 7 hours before you need to get up. Taking it with or soon after a meal can make it work more slowly.

Next-morning sleepiness can happen, so don’t drive if you feel at all drowsy. Avoid alcohol and other sedatives unless we’ve reviewed them. Some people briefly can’t move or see dream-like images while falling asleep or waking, or have sudden leg weakness. If you sleepwalk, drive or do things you don’t remember, stop it and call us. Call the same day for worsening depression or thoughts of self-harm. If you might act on those thoughts, call 911. Some antibiotics, antifungals and seizure medicines change its effect, so check before starting new medicines.

Clinical reference

Dose options

Insomnia (sleep onset and/or maintenance)

10 mg within 30 minutes of bedtime with ≥7 hours before planned waking; may increase to 20 mg maximum

Once nightly at most. Caution against next-day driving at 20 mg. AASM 2017 (weak) supports suvorexant for sleep maintenance.

CYP3A interactions and hepatic impairment

Moderate CYP3A inhibitors: 5 mg (generally ≤10 mg); strong inhibitors: not recommended; strong inducers may reduce efficacy

Severe hepatic impairment: not recommended.

Same class

Lemborexant (Dayvigo) and daridorexant (Quviviq)

Alternatives with their own labeled doses. All three are Schedule IV; DEA proposed moving them to Schedule V in August 2026 (not final).

Before prescribing

Narcolepsy is a contraindication. Assess sleep apnea and respiratory function, depression or suicidality, substance use, alcohol and sedatives, CYP3A inhibitors or inducers, hepatic function and next-day driving needs. Schedule IV controlled substance.

Side effects and return precautions

Dose-related next-day impairment; sleep paralysis, hypnagogic or hypnopompic hallucinations and cataplexy-like symptoms; complex sleep behaviors (stop); worsening depression or suicidal ideation.

Follow-up

Reevaluate if insomnia persists after 7–10 days. Review sleep, next-day function and driving safety; continue CBT-I and reassess ongoing need.

Sources

Checked October 15, 2026.

Suzetrigine (Journavx)Moderate to severe acute pain

What to say

Suzetrigine is a non-opioid medicine for short-term moderate to severe pain. It blocks pain signals in nerves before they reach the brain. Take the first dose, 100 milligrams, on an empty stomach, at least 1 hour before or 2 hours after food; water, tea or black coffee are fine. Starting 12 hours later, take 50 milligrams every 12 hours, with or without food. Swallow tablets whole. It hasn’t been studied beyond 14 days.

Itching, muscle spasms and rash are the most common side effects. Avoid grapefruit. Some antibiotic, antifungal, HIV and seizure medicines interact strongly, so check with us before starting anything new. If your birth control contains a progestin other than levonorgestrel or norethindrone, also use condoms or another method during treatment and for 28 days after. Call us if pain isn’t controlled. Call 911 for trouble breathing or facial swelling.

Clinical reference

Dose options

Adult acute pain

100 mg once on an empty stomach, then 50 mg every 12 hours starting 12 hours later

Not studied beyond 14 days. Missed dose: take it as soon as possible; if 2 or more are missed, take 100 mg, then resume the schedule.

Moderate CYP3A inhibitor or Child-Pugh B

100 mg, then 50 mg every 12 hours for doses 2–4, then 50 mg every 24 hours

Missed dose: take it as soon as possible and skip the next one if it’s due within 6 hours. Avoid in Child-Pugh C and eGFR <15 mL/min.

  • First-in-class non-opioid NaV1.8 blocker, FDA-approved January 30, 2025; pivotal trials followed abdominoplasty and bunionectomy.

Before prescribing

Contraindicated with strong CYP3A inhibitors; avoid strong or moderate CYP3A inducers and grapefruit. Review sensitive CYP3A substrates, hepatic function, eGFR <15 and contraceptive progestin. Check coverage and cost.

Side effects and return precautions

Pruritus, muscle spasms, increased CK and rash were the most common adverse reactions (about 1–2%). Inhibitors and moderate hepatic impairment raise exposure; inducers may reduce efficacy.

Follow-up

Review pain and function within days and stop when no longer needed. Remind patients using affected progestins about backup contraception for 28 days after the last dose.

Sources

Checked October 15, 2026.

Tacrolimus 0.1% ointment (Protopic)Eczema on the face and eyelids

What to say

For eczema on your face or eyelids, apply a thin layer of tacrolimus 0.1% ointment to the affected skin twice a day. It isn’t a steroid, so we often use it on thin skin. Stop when the rash clears, and restart at the first sign of a flare. Keep it out of your eyes and mouth, don’t cover it with bandages, and keep using your moisturizer.

Burning, stinging or itching is common in the first few days and fades as the skin heals. Alcohol may make your face flush. Limit sun exposure and avoid tanning beds, even when the ointment isn’t on. A boxed warning mentions rare cancers, though a cause hasn’t been shown. Call the same day for painful clusters of blisters or crusted sores, especially with fever, or for spreading redness or pus. Tell us about swollen glands. If you’re not better in 6 weeks, we’ll recheck.

Clinical reference

Dose options

Adult atopic dermatitis flare (face, eyelids, folds)

0.03% or 0.1% ointment: thin layer twice daily to affected skin; stop when clear

US label: second-line, short-term and non-continuous use when other topical Rx treatments fail or are inadvisable; no occlusion. Re-examine if not improved within 6 weeks.

Proactive maintenance for frequent flares

Once daily, twice weekly (e.g., Monday and Thursday) to usual flare sites after clearance

EU-labeled (EMA) for 4 or more flares a year after response to up to 6 weeks of twice-daily use; review at 12 months. Not in the US label, which advises against continuous long-term use.

Before prescribing

Confirm atopic dermatitis; resolve bacterial or viral skin infection first. Not for immunocompromised patients or under occlusion. Boxed warning: rare skin cancer and lymphoma reports without established causation; limit to affected areas and avoid continuous long-term use.

Side effects and return precautions

Application-site burning and pruritus (mostly first days; median episode 15 minutes), alcohol-related flushing, folliculitis. HSV, VZV and eczema herpeticum. Investigate lymphadenopathy; stop if no clear cause or with acute mononucleosis.

Follow-up

Re-examine the diagnosis if not better by 6 weeks (US label; EU label suggests other options after 2 weeks). After clearance, stop, or plan twice-weekly proactive use for frequent flares.

Sources

Checked October 15, 2026.

Tadalafil (Cialis)Enlarged prostate, with or without ED

What to say

For your enlarged-prostate urinary symptoms, take tadalafil 5 milligrams once daily at a consistent time, with or without food. It can also help erection difficulty if that’s a concern for you. Don’t add an extra tablet before sex. Sexual stimulation is still needed for an erection. Headache, flushing, indigestion or backache can happen. Rise slowly if lightheaded.

Don’t combine it with nitroglycerin, other nitrates, poppers or riociguat. If you have chest pain, call 911, don’t take a nitrate, and tell the team when you last took tadalafil. Stop it and go to the emergency department for an erection lasting four hours. Stop and get immediate eye care or go to the emergency department for sudden vision loss. Sudden hearing loss needs immediate medical assessment. Let’s know about any new medicines before taking them. We’ll review urinary symptoms, blood pressure and side effects in about four weeks.

Clinical reference

Dose options

ED plus BPH, or BPH alone

5 mg orally once daily

For CrCl 30–50 mL/min, start 2.5 mg daily and consider 5 mg according to response. Daily use is not recommended if CrCl <30 or on dialysis.

Hepatic impairment and interactions

Daily use needs individualized review

Not recommended with severe hepatic impairment; use caution in mild/moderate impairment. Strong CYP3A4 inhibitors limit daily tadalafil to 2.5 mg.

Before prescribing

Review nitrates/poppers, riociguat, alpha blockers, CYP3A4 inhibitors, kidney/liver function and cardiovascular fitness for sex. Tadalafil plus an alpha blocker is not recommended by the label for BPH treatment. Evaluate urinary red flags before attributing symptoms to BPH.

Side effects and return precautions

Headache, dyspepsia, flushing and back/muscle pain are common. Hypotension, priapism and sudden sensory loss need action. If lifesaving nitrate treatment is considered, at least 48 hours after the last dose and close medical supervision are required; this is not permission for self-administration.

Follow-up

Review symptoms, BP and tolerability at 4–6 weeks. Discuss missed daily doses without doubling and reassess renal function when clinical status changes.

Sources

Checked September 22, 2026.

Tadalafil (Cialis)Erectile dysfunction, as needed

What to say

For erection difficulty, take tadalafil 10 milligrams before anticipated sexual activity, no more than once daily. It can help for up to 36 hours, but that doesn’t mean you’ll have a continuous erection. Sexual stimulation is still needed. We may adjust the dose based on benefit and side effects. Don’t combine it with a daily erection medicine. Headache, flushing, indigestion or backache can happen.

Don’t combine it with nitroglycerin, other nitrates, poppers or riociguat. If you have chest pain, call 911, don’t take a nitrate, and tell the team when you last took tadalafil. Stop it and go to the emergency department for an erection lasting four hours. Stop and get immediate eye care or go to the emergency department for sudden vision loss. Sudden hearing loss needs immediate medical assessment. Let’s know about any new medicines before taking them. We’ll review benefit, blood pressure and side effects in about four weeks.

Clinical reference

Dose options

ED: as needed

10 mg before anticipated activity; adjust to 5–20 mg, no more than once daily

CrCl 30–50: start 5 mg, maximum 10 mg every 48 hours. CrCl <30/dialysis: maximum 5 mg every 72 hours.

Liver disease and interactions

Individualize before prescribing

Severe hepatic impairment: not recommended. Strong CYP3A4 inhibitors and other hepatic impairment require schedule-specific restrictions.

Before prescribing

Review nitrates/poppers, riociguat, alpha blockers, strong CYP3A4 inhibitors, renal/hepatic function and cardiovascular fitness for sex. Assess contributing vascular, metabolic and medication causes of ED. Do not combine PDE5 inhibitors.

Side effects and return precautions

Headache, dyspepsia, flushing and back/muscle pain are common. Hypotension, priapism and sudden sensory loss need action. If lifesaving nitrate treatment is considered, at least 48 hours after the last dose and close medical supervision are required; this is not permission for self-administration.

Follow-up

Review erectile function, tolerability and BP in 4–6 weeks. Reassess cardiovascular and renal/hepatic status when indicated; adjust the chosen schedule rather than combining daily and as-needed doses.

Sources

Checked September 22, 2026.

Tadalafil (Cialis)Erectile dysfunction, daily

What to say

For erection difficulty, take tadalafil 2.5 milligrams once daily at a consistent time, with or without food. You won’t need to time it around sex, but sexual stimulation is still needed. We may increase to 5 milligrams after reviewing the response. Don’t add an extra dose before sex or combine it with other erection medicines. Headache, flushing, indigestion or backache can happen.

Don’t combine it with nitroglycerin, other nitrates, poppers or riociguat. If you have chest pain, call 911, don’t take a nitrate, and tell the team when you last took tadalafil. Stop it and go to the emergency department for an erection lasting four hours. Stop and get immediate eye care or go to the emergency department for sudden vision loss. Sudden hearing loss needs immediate medical assessment. Let’s know about any new medicines before taking them. We’ll review benefit, blood pressure and side effects in about four weeks.

Clinical reference

Dose options

ED: daily alternative

2.5 mg daily; may increase to 5 mg

Do not combine with as-needed tadalafil or another PDE5 inhibitor. Severe hepatic impairment: avoid; other hepatic impairment and strong CYP3A4 inhibitors require product-specific restrictions.

Renal function

Daily use not recommended with CrCl <30 or dialysis

Use the daily-ED label instructions; the 2.5-mg renal starting recommendation for BPH is a different indication.

Liver disease and interactions

Individualize before prescribing

Severe hepatic impairment: not recommended. Strong CYP3A4 inhibitors and other hepatic impairment require schedule-specific restrictions.

Before prescribing

Review nitrates/poppers, riociguat, alpha blockers, strong CYP3A4 inhibitors, renal/hepatic function and cardiovascular fitness for sex. Assess contributing vascular, metabolic and medication causes of ED. Do not combine PDE5 inhibitors.

Side effects and return precautions

Headache, dyspepsia, flushing and back/muscle pain are common. Hypotension, priapism and sudden sensory loss need action. If lifesaving nitrate treatment is considered, at least 48 hours after the last dose and close medical supervision are required; this is not permission for self-administration.

Follow-up

Review erectile function, tolerability and BP in 4–6 weeks. Reassess cardiovascular and renal/hepatic status when indicated; adjust the chosen schedule rather than combining daily and as-needed doses.

Sources

Checked September 22, 2026.

Tamsulosin (Flomax)Enlarged prostate (BPH)

What to say

Tamsulosin relaxes muscle around the prostate and bladder opening to help urine flow. Start 0.4 milligrams once a day, about 30 minutes after the same meal each day. Swallow the capsule whole.

It can cause dizziness when you stand up, so rise slowly and be careful until you know its effect. Ejaculation may change. Let me know if that bothers you. Tell your eye surgeon you take it before cataract or glaucoma surgery, even if you have stopped it. We’ll review symptoms and dizziness in two to four weeks. If you can’t urinate, whether or not your belly hurts, or an erection lasts four hours, go to the emergency department.

Clinical reference

Dose options

BPH start

0.4 mg orally once daily, about 30 minutes after the same meal

Swallow capsule whole.

Escalation

May increase to 0.8 mg daily after 2–4 weeks if response inadequate

Assess orthostasis and alternative explanations for symptoms first.

Restart / organ function

If interrupted for several days, restart at 0.4 mg

No routine renal adjustment; ESRD CrCl <10 not studied. Review strong CYP3A4 and other interactions.

Before prescribing

Assess LUTS cause, BP/orthostasis, urinary retention, prostate evaluation as indicated, PDE5 inhibitors, other alpha blockers and CYP interactions. Tamsulosin improves symptoms but does not shrink the prostate.

Side effects and return precautions

Dizziness/orthostasis, nasal symptoms and ejaculation changes. Syncope needs assessment; retention and priapism are emergencies. Intraoperative floppy iris risk requires eye-team notification.

Follow-up

Review symptoms, BP and adverse effects in 2–4 weeks before any increase; assess inadequate response or concerning urinary features.

Sources

Checked September 20, 2026.

Tamsulosin (Flomax)Ureteral stone passage, off-label

What to say

For the stone we’ve identified in the lower ureter, tamsulosin may improve the chance of passing it without a procedure. This is an off-label use with the clearest benefit for stones larger than 5 millimeters. Take 0.4 milligrams once daily about 30 minutes after the same meal, until [review or stop date]. It relaxes the ureter. It doesn’t dissolve the stone.

Dizziness when standing or ejaculation changes can occur. Rise slowly and avoid driving if dizzy. Follow the pain plan and strain the urine if instructed. Fever or chills, inability to urinate, uncontrolled pain or persistent vomiting means seek urgent care immediately. Keep the follow-up appointment even if the pain stops so we can confirm the stone has passed.

Clinical reference

Dose options

Uncomplicated distal ureteral stone

0.4 mg orally once daily, with a defined short review/stop plan

Common trial duration is up to 4 weeks or confirmed passage, with earlier reassessment. Evidence of benefit is strongest for distal stones >5 to 10 mm; do not apply BPH dose escalation.

Before prescribing

Confirm stone size/location and suitability for observation. Exclude infected obstruction, renal deterioration, uncontrolled pain and other reasons for urgent intervention; review solitary kidney, pregnancy, hypotension and CYP3A4 interactions.

Side effects and return precautions

Orthostatic dizziness/syncope and ejaculation effects. Fever with obstruction or anuria is an emergency. Inform an ophthalmologist about tamsulosin before cataract/glaucoma surgery.

Follow-up

Arrange early clinical review and appropriate imaging to confirm passage. Stop if complications occur or intervention becomes necessary; do not continue indefinitely because symptoms improved.

Sources

Checked September 23, 2026.

Terbinafine (Lamisil)Toenail fungus

What to say

Terbinafine tablets treat the fungus in your toenail. Take 250 milligrams once a day for 12 weeks. The nail improves only as healthy nail grows out, which can take 12–18 months, so it won’t look clear when you finish. Not every nail clears, and the infection can return. Treat athlete’s foot, keep your feet dry and wear sandals in shared showers.

We’ll check liver tests before you start. Rarely, it causes serious liver damage: stop it and call us the same day for yellow skin or eyes, dark urine, pale stools, right upper belly pain, or ongoing nausea, tiredness or poor appetite. Also stop and call for a change in taste or smell, which can last a long time, or for low mood. A blistering or peeling rash, mouth sores, or face or throat swelling means go to the emergency department; trouble breathing means call 911. Check before starting new medicines.

Clinical reference

Dose options

Toenail onychomycosis

250 mg once daily for 12 weeks

Fingernails: 250 mg daily for 6 weeks. Labeled for dermatophyte onychomycosis; nail clearance lags months behind mycologic cure.

Liver and kidney

Contraindicated in chronic or active liver disease; check LFTs before starting

The label recommends periodic LFT monitoring; AAFP 2021 says further routine labs are unnecessary in immunocompetent patients. Not adequately studied with CrCl ≤50 mL/min.

Before prescribing

Confirm dermatophyte infection (KOH plus culture, PAS or PCR). Baseline LFTs; contraindicated with liver disease or prior oral terbinafine allergy. Review CYP2D6 substrates (TCAs, SSRIs, beta blockers, flecainide, tamoxifen), lupus, immunodeficiency, pregnancy.

Side effects and return precautions

Hepatotoxicity, taste or smell loss (sometimes permanent), depression, neutropenia, SJS/TEN/DRESS, lupus, thrombotic microangiopathy. Stop for liver symptoms, taste or smell change or progressive rash. CYP2D6 inhibition persists weeks after stopping.

Follow-up

Check LFTs promptly for liver symptoms. Judge success by clear regrowth over 12–18 months. Relapse is common (about 25%); treat tinea pedis and consider twice-weekly topical antifungal prophylaxis afterward.

Sources

Checked October 15, 2026.

Testosterone 1.62% gel (AndroGel)Male hypogonadism

What to say

Your symptoms and two separate morning blood tests support testosterone deficiency. We’re starting the 1.62% gel at two pump presses, totaling 40.5 milligrams, each morning. Apply it to clean, dry shoulders and upper arms, let it dry, wash your hands and cover the area. Before skin contact with another person, wash the application sites. Keep children and pregnant partners away from unwashed sites. Wash accidental contact immediately. Wait at least two hours before showering or swimming.

Testosterone can reduce sperm production, so tell me before using it if you want future fertility. Acne, swelling or mood changes can happen. We’ll check a morning level before your dose around days 14 and 28, and monitor blood pressure and blood counts. Prostate monitoring depends on your age and preferences. Call 911 for severe breathlessness, chest pain, a drooping face, arm weakness or trouble speaking. Don’t change the number of pumps yourself.

Clinical reference

Dose options

1.62% metered gel: start

40.5 mg (two pump actuations) each morning

Apply only to shoulders/upper arms. Other gel concentrations have different pumps, sites and monitoring.

1.62% gel titration

20.25–81 mg daily, in 20.25 mg steps

Use a pre-dose morning testosterone around days 14 and 28 after starting or changing dose; follow the product’s level-based algorithm.

Before prescribing

Confirm symptoms plus two low early-morning fasting testosterone levels and investigate the cause with LH/FSH as indicated. Assess fertility, hematocrit, BP, sleep apnea, cardiovascular stability, LUTS and prostate risk. Avoid therapy for near-term fertility plans, elevated hematocrit or relevant untreated/unstable conditions. Not a gender-affirming hormone protocol. In June 2026 the FDA requested label revisions on age-related hypogonadism and prostate/BPH; follow the prescribed product’s current label until they take effect, and involve urology for a cancer history.

Side effects and return precautions

Secondary skin exposure, erythrocytosis, infertility, edema and BP increases require active prevention/monitoring. The current gel label advises against use with uncontrolled hypertension. Stop and assess if hematocrit exceeds 54%; evaluate hypoxia/OSA before a lower-dose restart.

Follow-up

Gel levels at approximately 14 and 28 days; symptoms and adverse effects at 3–6 months. Hematocrit at baseline, 3–6 months and annually; BP periodically. Discuss PSA/prostate assessment before treatment and at 3–12 months when monitoring is chosen, with referral for concerning changes.

Sources

Checked September 22, 2026.

Testosterone cypionate injection (Depo-Testosterone)Male hypogonadism

What to say

Your symptoms and two morning tests support testosterone deficiency. For the injection plan we’ve chosen, start testosterone cypionate 100 milligrams into the muscle once weekly. We’ll show you the technique and confirm the exact volume for your vial’s concentration before the first dose. Never guess the amount from a different vial, and use a sharps container.

Testosterone can reduce sperm production, so tell us about fertility plans. Acne, swelling, mood changes or injection-site soreness can occur. We’ll time the testosterone blood test halfway between injections and monitor blood pressure and blood counts. Prostate monitoring depends on your age and preferences. Call 911 for severe breathlessness, chest pain or stroke symptoms. Don’t increase the dose or shorten the interval yourself.

Clinical reference

Dose options

Adult male hypogonadism: IM cypionate

75–100 mg IM weekly or 150–200 mg IM every two weeks

Endocrine Society regimen. Confirm vial concentration and injection teaching; measure testosterone midway between injections to guide adjustment.

Before prescribing

Confirm symptoms plus two low early-morning fasting testosterone levels and investigate the cause with LH/FSH as indicated. Assess fertility, hematocrit, BP, sleep apnea, cardiovascular stability, LUTS and prostate risk. Avoid therapy for near-term fertility plans, elevated hematocrit or relevant untreated/unstable conditions. Not a gender-affirming hormone protocol. In June 2026 the FDA requested label revisions on age-related hypogonadism and prostate/BPH; follow the prescribed product’s current label until they take effect, and involve urology for a cancer history. The current Depo-Testosterone label contraindicates known/suspected prostate cancer, male breast cancer and serious cardiac, hepatic or renal disease; proposed FDA label changes do not override it. Avoid uncontrolled hypertension.

Side effects and return precautions

Erythrocytosis, infertility, BP increases, edema, acne, mood fluctuations and injection-site effects. Hold and evaluate hematocrit >54%, including hypoxia/OSA; restart only under a revised plan. Acute chest/breathing symptoms or stroke signs need emergency care.

Follow-up

Measure testosterone midway between injections for adjustment; review symptoms/adverse effects at 3–6 months. Hematocrit at baseline, 3–6 months and annually; monitor BP. Discuss prostate monitoring at baseline and 3–12 months when chosen, with referral for concerning changes.

Sources

Checked September 22, 2026.

Ticagrelor (Brilinta)After acute coronary syndrome

What to say

Ticagrelor keeps platelets from clumping, which helps prevent another heart attack or a clot in your stent. Take 90 milligrams twice a day with low-dose aspirin, 81 milligrams daily, unless your cardiologist stops the aspirin; don’t take more aspirin than that. Most people take it for at least a year. If you miss a dose, take the next one on time. Don’t stop it, even for a procedure, unless your cardiologist agrees; stopping early can cause a heart attack.

You’ll bruise and bleed more easily; avoid ibuprofen and naproxen. Mild shortness of breath is common and often fades; call if it’s worse or lasting. Get emergency care for black or bloody stools, vomiting blood, or bleeding that won’t stop. Call 911 for chest pain, fainting, sudden weakness or a severe headache. Check with us before new medicines; some antibiotics and antifungals interact.

Clinical reference

Dose options

ACS: first 12 months

180 mg load, then 90 mg twice daily with aspirin 75–100 mg daily

Avoid aspirin >100 mg/day. 2025 ACC/AHA ACS: DAPT ≥12 months if not at high bleeding risk; ticagrelor or prasugrel preferred over clopidogrel with PCI.

Aspirin-free option after PCI

Ticagrelor 90 mg twice daily alone, from ≥1 month after PCI in patients who tolerated DAPT

2025 ACC/AHA ACS (COR 1) to reduce bleeding; the 2026 label allows single antiplatelet therapy after PCI. Cardiology sets timing.

Beyond 12 months (history of MI)

60 mg twice daily with aspirin 75–100 mg daily

For selected patients at high ischemic and acceptable bleeding risk, per cardiology.

Before prescribing

Contraindicated: prior intracranial hemorrhage, active bleeding, hypersensitivity. Avoid strong CYP3A inhibitors or inducers and severe hepatic impairment; keep simvastatin/lovastatin ≤40 mg; monitor digoxin. Review sinus node disease or AV block, anticoagulant need and GI bleeding risk (PPI).

Side effects and return precautions

Bleeding (boxed warning); dyspnea in 14–21%, usually mild and often resolving; bradyarrhythmia or AV block; central sleep apnea. Causes false-negative functional HIT assays.

Follow-up

Coordinate any interruption with cardiology; when possible hold 5 days before surgery with major bleeding risk and restart once hemostasis allows. Revisit regimen at 1 and 12 months.

Sources

Checked October 15, 2026.

Tiotropium (Spiriva HandiHaler)COPD

What to say

For your COPD, use one Spiriva HandiHaler 18-microgram capsule each day. Put it in the HandiHaler device, pierce it as shown, and inhale from that same capsule twice to get the full dose. Never swallow the capsule or put it in a different device. This keeps the airways open over the day. Use your separate rescue medicine for sudden breathing symptoms.

Let’s practice loading the capsule and breathing in. Dry mouth or constipation can happen. Keep the powder out of your eyes. Stop and get urgent eye care for eye pain, redness, blurred vision or halos. Inability to pass urine needs emergency assessment. If an inhalation immediately worsens breathing, stop the inhaler and follow your urgent plan. Severe breathlessness means call 911.

Clinical reference

Dose options

COPD: HandiHaler

Inhale the contents of one 18-mcg capsule using two inhalations once daily

Only use the HandiHaler device; never swallow the capsule. Do not substitute Respimat puff counts.

Renal function

No fixed renal dose adjustment

Monitor anticholinergic effects closely with moderate/severe renal impairment.

Before prescribing

Review narrow-angle glaucoma, urinary retention/prostate disease, renal impairment, other anticholinergics and device capability. Confirm maintenance and rescue roles. Review severe milk-protein allergy for this lactose-containing powder device.

Side effects and return precautions

Dry mouth/constipation; urinary retention, acute eye symptoms, hypersensitivity or paradoxical bronchospasm need immediate action.

Follow-up

Review symptoms, rescue use, constipation/urinary effects and technique after initiation; do not escalate beyond the product-specific daily dose.

Sources

Checked September 22, 2026.

Tiotropium (Spiriva Respimat)Asthma

What to say

For your asthma, add two puffs of Spiriva Respimat 1.25 micrograms per puff together once daily, a total of 2.5 micrograms. Keep taking your prescribed inhaled steroid treatment. This is an add-on maintenance inhaler, not rescue treatment. Keep your rescue medicine available. Full benefit may take four to eight weeks.

Let’s review inserting the cartridge, priming and taking a slow breath as you press the button. This is the Respimat mist device, not the capsule device. Dry mouth or constipation can happen. Keep the mist out of your eyes. Stop it and get immediate eye care or go to the emergency department for eye pain with redness, blurred vision or halos. If you can’t pass urine, go to the emergency department. If a puff immediately worsens breathing, stop that inhaler and follow your urgent breathing plan. Severe breathing trouble means call 911. We’ll review symptoms and technique in about a month.

Clinical reference

Dose options

Asthma: Respimat

2 inhalations of 1.25 mcg per actuation once daily

Total 2.5 mcg/day, as add-on maintenance; maximal benefit may take 4–8 weeks.

Renal function

No fixed renal dose adjustment

Monitor anticholinergic effects closely with moderate/severe renal impairment.

Before prescribing

Review narrow-angle glaucoma, urinary retention/prostate disease, renal impairment, other anticholinergics and device capability. Confirm maintenance and rescue roles.

Side effects and return precautions

Dry mouth/constipation; urinary retention, acute eye symptoms, hypersensitivity or paradoxical bronchospasm need immediate action.

Follow-up

Review symptoms, rescue use, constipation/urinary effects and technique after initiation; do not escalate beyond the product-specific daily dose.

Sources

Checked September 22, 2026.

Tiotropium (Spiriva Respimat)COPD

What to say

For your COPD, use two puffs of Spiriva Respimat 2.5 micrograms per puff together once a day. That’s a total of 5 micrograms daily. It helps keep the airways open, but it doesn’t treat a sudden breathing attack. Keep your separate rescue medicine available.

Let’s review inserting the cartridge, priming and taking a slow breath as you press the button. This is the Respimat mist device, not the capsule device. Dry mouth or constipation can happen. Keep the mist out of your eyes. Stop it and get immediate eye care or go to the emergency department for eye pain with redness, blurred vision or halos. If you can’t pass urine, go to the emergency department. If a puff immediately worsens breathing, stop that inhaler and follow your urgent breathing plan. Severe breathing trouble means call 911. We’ll review symptoms and technique in about a month.

Clinical reference

Dose options

COPD: Respimat

2 inhalations of 2.5 mcg per actuation once daily

Total 5 mcg/day; the wording above uses this product.

Renal function

No fixed renal dose adjustment

Monitor anticholinergic effects closely with moderate/severe renal impairment.

Before prescribing

Review narrow-angle glaucoma, urinary retention/prostate disease, renal impairment, other anticholinergics and device capability. Confirm maintenance and rescue roles.

Side effects and return precautions

Dry mouth/constipation; urinary retention, acute eye symptoms, hypersensitivity or paradoxical bronchospasm need immediate action.

Follow-up

Review symptoms, rescue use, constipation/urinary effects and technique after initiation; do not escalate beyond the product-specific daily dose.

Sources

Checked September 22, 2026.

Tirzepatide injection (Mounjaro)Type 2 diabetes

What to say

To help lower your blood sugar, start Mounjaro 2.5 milligrams once weekly. After at least four weeks, we’ll review your readings and side effects before deciding whether to increase. Let’s confirm your injection device and technique. If you also use insulin or a sulfonylurea, we’ll make a plan to prevent low blood sugar. Don’t change those doses on your own.

Nausea, fullness, diarrhea or constipation can happen. Call the same day if you can’t keep fluids down. Severe persistent belly pain, with or without vomiting, means stop it and go to the emergency department. Birth-control pills can work less reliably: add a barrier method or switch to a nonoral method for four weeks after starting and after each increase. Tell us about medullary thyroid cancer or MEN2 in you or your family, planned anesthesia, or pregnancy so we can review treatment promptly.

Clinical reference

Dose options

Mounjaro: type 2 diabetes

Start 2.5 mg subcutaneously weekly; if additional glycemic control is needed, increase by 2.5 mg after ≥4 weeks on the current dose

Current August 2026 PI; do not apply Zepbound’s mandatory initiation-to-5-mg wording. Adult maximum 15 mg weekly.

Before prescribing

Check exact product, MTC/MEN2, pregnancy, severe gastric-emptying problems, pancreatic/gallbladder history, retinopathy and diabetes drugs. No duplicate tirzepatide/GLP-1 therapy.

Side effects and return precautions

GI intolerance, dehydration, pancreatic/gallbladder symptoms and hypoglycemia with insulin/secretagogues. Oral contraception requires four weeks of backup after initiation and each increase. Pregnancy needs immediate individualized diabetes review.

Follow-up

Review intake, tolerance and glucose/weight before escalation. Missed dose: within 96 hours, otherwise skip; ≥72 hours between doses. Discuss retitration after longer interruptions.

Sources

Checked September 22, 2026.

Tirzepatide injection (Zepbound)Obstructive sleep apnea

What to say

Because you have obesity and moderate-to-severe obstructive sleep apnea, we’re adding Zepbound to help treat the sleep apnea as you lose weight. Start 2.5 milligrams weekly for four weeks, then 5 milligrams if tolerated. We’ll increase gradually toward the sleep-apnea dose. Keep using your prescribed CPAP or other sleep-apnea treatment until the sleep team reassesses it. Feeling better alone isn’t a reason to stop.

Nausea, fullness, diarrhea or constipation are common early. Call the same day if you can’t keep fluids down or are becoming dehydrated. Don’t increase while symptoms are troublesome. Severe persistent belly pain, with or without vomiting, means stop it and go to the emergency department. If you use birth-control pills, add condoms or another barrier method, or switch to a method other than pills, for four weeks after starting and for four weeks after every increase. Tell me about medullary thyroid cancer or MEN2, an inherited condition, in you or your family, pregnancy plans and any upcoming anesthesia. Stop Zepbound and call if you become pregnant.

Clinical reference

Dose options

Initiation and escalation

2.5 mg subcutaneously weekly for four weeks, then 5 mg weekly

Further increases are 2.5 mg at intervals of at least four weeks, based on response and tolerance.

OSA maintenance

10 or 15 mg weekly; maximum 15 mg weekly

For moderate-to-severe OSA in adults with obesity, alongside reduced-calorie diet and activity. No routine renal/hepatic dose adjustment; monitor renal function with dehydration.

Before prescribing

Check exact product, MTC/MEN2, pregnancy, severe gastric-emptying problems, pancreatic/gallbladder history, retinopathy and diabetes drugs. No duplicate tirzepatide/GLP-1 therapy. Confirm documented moderate-to-severe OSA and obesity; coordinate PAP and follow-up testing with the sleep clinician.

Side effects and return precautions

GI effects, dehydration and pancreatitis/gallbladder symptoms; stop for pregnancy. Oral contraceptive backup for four weeks after starting and each increase. Do not stop PAP independently; address persistent sleepiness and driving risk.

Follow-up

Review tolerance before escalation, weight, daytime sleepiness and PAP use. Coordinate repeat OSA assessment before changing airway therapy. Missed dose: within 96 hours, otherwise skip; at least 72 hours between injections.

Sources

Checked September 22, 2026.

Tirzepatide injection (Zepbound)Weight management

What to say

To support weight loss, we’ll start Zepbound at 2.5 milligrams once a week for four weeks, then increase to 5 milligrams if you’re tolerating it. Further increases are gradual and depend on benefit and side effects, not just the calendar. Let’s confirm the injection device and technique.

Nausea, fullness, diarrhea or constipation are common early. Call the same day if you can’t keep fluids down or are becoming dehydrated. Don’t increase while symptoms are troublesome. Severe persistent belly pain, with or without vomiting, means stop it and go to the emergency department. If you use birth-control pills, add condoms or another barrier method, or switch to a method other than pills, for four weeks after starting and for four weeks after every increase. Tell me about medullary thyroid cancer or MEN2, an inherited condition, in you or your family, pregnancy plans and any upcoming anesthesia. Stop Zepbound and call if you become pregnant.

Clinical reference

Dose options

Zepbound: weight reduction

2.5 mg weekly ×4 weeks, then 5 mg; subsequent 2.5-mg increases after ≥4 weeks

2.5 mg is initiation-only. Weight maintenance doses: 5, 10 or 15 mg weekly; maximum 15 mg.

Before prescribing

Check exact product, MTC/MEN2, pregnancy, severe gastric-emptying problems, pancreatic/gallbladder history, retinopathy and diabetes drugs. No duplicate tirzepatide/GLP-1 therapy.

Side effects and return precautions

GI intolerance, dehydration, pancreatitis and gallbladder symptoms require assessment. Stop for pregnancy. Oral contraception needs a nonoral method or barrier backup for four weeks after starting and each increase.

Follow-up

Review intake, tolerance and glucose/weight before escalation. Missed dose: within 96 hours, otherwise skip; ≥72 hours between doses. Discuss retitration after longer interruptions.

Sources

Checked September 22, 2026.

Tizanidine (Zanaflex)Muscle spasm, off-label

What to say

For this flare of back spasm, we’re using tizanidine off-label for a short time. It’s approved for spasticity but can also ease painful spasm. Start with 2 milligrams at bedtime. If needed, take 2 milligrams every 6–8 hours, no more than 3 doses in 24 hours. Take it the same way each time, always with food or always without.

Sleepiness, dizziness, dry mouth and weakness are common. It can lower blood pressure, so stand up slowly, and don’t drive until you know how it affects you. Avoid alcohol and other sedating medicines. Never take it with ciprofloxacin or fluvoxamine, and tell us about birth control pills or blood pressure medicines. Call us for yellow skin or eyes, dark urine, or seeing things that aren’t there. Fainting needs same-day care; trouble breathing or facial swelling means call 911. After regular use, don’t stop suddenly.

Clinical reference

Dose options

Acute spasm, off-label short course

2 mg at bedtime or every 6–8 hours as needed; maximum 3 doses/24 hours

Label (spasticity) allows increases of 2–4 mg per dose every 1–4 days to 36 mg/day; keep acute use to the lowest dose for days, not weeks.

Renal or hepatic impairment; formulation

CrCl <25 mL/min or hepatic impairment: lower individual doses; raise dose size rather than frequency

Capsules and tablets differ when taken with food, as do fed and fasting doses; keep the same product and food pattern.

  • Off-label: FDA-labeled only for spasticity. ACP 2017 supports a skeletal muscle relaxant for acute or subacute low back pain when medicine is wanted.

Before prescribing

Off-label for back spasm (labeled for spasticity). Contraindicated with strong CYP1A2 inhibitors (ciprofloxacin, fluvoxamine); avoid moderate/weak inhibitors and oral contraceptives. Review antihypertensives, other α2 agonists, sedatives, falls, renal/hepatic function; label advises baseline aminotransferases.

Side effects and return precautions

Sedation, dizziness, dry mouth, asthenia; hypotension, bradycardia, syncope; hepatocellular injury; hallucinations; anaphylaxis. Abrupt stop after regular use can cause rebound hypertension, tachycardia and hypertonia.

Follow-up

Reassess within 1–2 weeks and stop when spasm settles. If continued, check aminotransferases 1 month after reaching the maximum dose. Taper by 2–4 mg/day after prolonged or high-dose use.

Sources

Checked October 15, 2026.

Topical nifedipine (compounded)Anal fissure, off-label

What to say

A fissure is a small tear that keeps reopening because the muscle around it stays tight. A compounding pharmacy makes nifedipine, a blood pressure medicine, into an ointment that relaxes this muscle so the tear can heal. This is an off-label use. Twice a day, use a gloved finger to apply the amount on your label just inside the anal opening, or on the outer edge if that hurts too much. Wash your hands afterward. Continue for 6–8 weeks.

Keep stools soft with fiber and fluids, and sit in a few inches of warm water after bowel movements. Headache or dizziness can happen, though less often than with nitroglycerin ointment. Call us for bleeding beyond streaks on the paper, fever, or a painful swelling near the anus. Heavy bleeding means go to the emergency department; fainting means call 911. If it hasn’t healed by [date], we’ll discuss a specialist for a Botox injection or minor surgery.

Clinical reference

Dose options

Compounded nifedipine ointment (off-label)

0.2–0.3% applied to the anal canal or verge twice daily for 6–8 weeks

Trial regimen: 0.3% nifedipine with 1.5% lidocaine every 12 hours for 6 weeks healed 94.5% vs 16.4% with control. ASCRS 2023: topical CCBs heal as well as nitrates with fewer side effects and can be first line.

Alternative compounded CCB

Diltiazem 2% ointment

Off-label. In trials reviewed by ASCRS, healing was similar to nitroglycerin, with less headache.

Labeled option: nitroglycerin 0.4% (Rectiv)

1 inch (1.5 mg) intra-anally every 12 hours for up to 3 weeks

Labeled for moderate to severe chronic fissure pain. Headache in 64% vs 41% with placebo. Contraindicated within a few days of PDE5 inhibitors and with severe anemia or raised intracranial pressure.

  • Compounded preparations aren’t FDA-approved; strength, base and price vary by pharmacy, so confirm a local source before prescribing.

Before prescribing

Confirm a typical midline fissure; lateral, multiple, painless or nonhealing fissures need evaluation for Crohn disease, HIV, syphilis, TB or cancer. Review hypotension, CCB allergy and pregnancy; ask about PDE5 inhibitors before nitroglycerin.

Side effects and return precautions

Headache, dizziness and local irritation. Fever, perianal swelling or purulent drainage suggests abscess; heavy bleeding or syncope needs urgent assessment.

Follow-up

Reassess at 6–8 weeks. If not healed, refer to colorectal surgery for botulinum toxin or lateral internal sphincterotomy. Continue fiber after healing; maintenance fiber lowered recurrence in a trial.

Sources

Checked October 15, 2026.

Topiramate (Topamax)Epilepsy, add-on treatment

What to say

We’re adding topiramate to help reduce your seizures. Continue your other seizure medicines. Start at the low dose on your written plan and increase only at the agreed weekly steps. The eventual dose depends on your seizure type, kidney function and side effects. This is the immediate-release formulation.

Tingling, appetite loss or trouble finding words can happen. Tell us if thinking or mood changes. Sudden eye pain or blurred vision needs immediate medical care. Stop the medicine while getting urgent advice. Stop it and seek urgent assessment for a new rash. Blistering, mouth sores, facial swelling or trouble breathing need emergency care. Call promptly for thoughts of self-harm. Immediate danger means 911.

Topiramate can harm a pregnancy and can reduce the effectiveness of some hormonal contraception. We’ll agree on contraception before treatment. Contact the epilepsy team promptly if pregnancy occurs or is planned. Don’t abruptly stop seizure treatment yourself. Keep a seizure record and follow your rescue plan.

Follow your seizure action plan. Call 911 for a seizure lasting more than five minutes, repeated seizures without recovery, or trouble breathing or waking afterward.

Clinical reference

Dose options

Adult add-on initiation

Start total 25–50 mg/day; increase total daily dose by 25–50 mg at weekly intervals

Use the neurologist’s written schedule, with maintenance in two divided doses.

Adult maintenance by seizure type

Focal seizures or Lennox-Gastaut: 200–400 mg/day; primary generalized tonic-clonic: 400 mg/day

Divide into two daily doses and individualize to response. The label does not show better focal-seizure responses above 400 mg/day.

Renal adjustment

CrCl <70 mL/min/1.73 m²: one-half of the usual adult dose

Allow more time to reach steady state. Dialysis requires an individualized supplemental dose; extended-release products have different instructions.

Before prescribing

Confirm seizure type, immediate-release formulation and neurology plan. Check renal function, bicarbonate, pregnancy/contraception, stone history, weight, mood and cognition. Review valproate, carbonic-anhydrase inhibitors, ketogenic diets and other interactions.

Side effects and return precautions

Cognitive slowing, metabolic acidosis, kidney stones and reduced sweating/overheating. Encourage appropriate hydration. Valproate increases hyperammonemia/hypothermia concerns; unexplained lethargy, vomiting or confusion needs assessment. Monitor weight and mood.

Follow-up

Review during titration with neurology; track seizures and cognitive effects. Check bicarbonate at baseline and periodically, and reassess renal function as indicated. Give a written missed-dose and gradual-withdrawal plan; follow epilepsy driving restrictions.

Sources

Checked September 23, 2026.

Topiramate (Topamax)Epilepsy, single-drug treatment

What to say

Topiramate will be the main medicine for your [focal / generalized tonic-clonic] seizures. The immediate-release dose rises gradually according to the written neurology schedule. If you’re changing from another seizure medicine, keep following its separate taper plan. Starting topiramate doesn’t mean stopping the old medicine today.

Tingling, appetite loss or trouble finding words can happen. Tell us if thinking or mood changes. Sudden eye pain or blurred vision needs immediate medical care. Stop the medicine while getting urgent advice. Stop it and seek urgent assessment for a new rash. Blistering, mouth sores, facial swelling or trouble breathing need emergency care. Call promptly for thoughts of self-harm. Immediate danger means 911.

Topiramate can harm a pregnancy and can reduce the effectiveness of some hormonal contraception. We’ll agree on contraception before treatment. Contact the epilepsy team promptly if pregnancy occurs or is planned. Don’t abruptly stop seizure treatment yourself. Keep a seizure record and follow your rescue plan.

Follow your seizure action plan. Call 911 for a seizure lasting more than five minutes, repeated seizures without recovery, or trouble breathing or waking afterward.

Clinical reference

Dose options

Adult monotherapy, normal renal function

Twice-daily doses by week: 25 mg, 50 mg, 75 mg, 100 mg, 150 mg, then 200 mg per dose

Label titration reaches 400 mg/day in week 6. Individualize with neurology; do not reuse the lower migraine-prevention target. Conversion from other medicines needs a separate plan.

Renal adjustment

CrCl <70 mL/min/1.73 m²: one-half of the usual adult dose

Allow more time to reach steady state. Dialysis requires an individualized supplemental dose; extended-release products have different instructions.

Before prescribing

Confirm seizure type, immediate-release formulation and neurology plan. Check renal function, bicarbonate, pregnancy/contraception, stone history, weight, mood and cognition. Review valproate, carbonic-anhydrase inhibitors, ketogenic diets and other interactions.

Side effects and return precautions

Cognitive slowing, metabolic acidosis, kidney stones and reduced sweating/overheating. Encourage appropriate hydration. Valproate increases hyperammonemia/hypothermia concerns; unexplained lethargy, vomiting or confusion needs assessment. Monitor weight and mood.

Follow-up

Review during titration with neurology; track seizures and cognitive effects. Check bicarbonate at baseline and periodically, and reassess renal function as indicated. Give a written missed-dose and gradual-withdrawal plan; follow epilepsy driving restrictions.

Sources

Checked September 23, 2026.

Topiramate (Topamax)Migraine prevention

What to say

Topiramate is a daily medicine to prevent migraines. Start 25 milligrams at bedtime for one week. If tolerated, take 25 milligrams twice daily in week two, then 25 in the morning and 50 at bedtime in week three, then 50 twice daily in week four. We can slow down if side effects are troublesome. We’ll give you this weekly schedule in writing. Keep using your separate plan for a migraine that breaks through. Topiramate can harm a pregnancy. Use the contraception plan we discussed and tell us before trying to conceive.

Tingling, changes in taste, reduced appetite or trouble finding words can happen. Tell me if thinking or concentration is affected. Sudden eye pain or blurred vision means stop it and get immediate eye care or go to the emergency department. Call the same day for a major mood change or pregnancy. If you can’t stay safe, call 911. We’ll review your headache diary and side effects in about a month, and check the blood tests we’ve arranged. Don’t stop regular treatment abruptly without a plan.

Clinical reference

Dose options

Migraine prevention, immediate release

Week 1: 25 mg nightly; week 2: 25 mg twice daily; week 3: 25 mg AM/50 mg PM; week 4: 50 mg twice daily

Usual target 100 mg/day divided; longer titration intervals may improve tolerance. Not an acute migraine treatment.

Renal adjustment

CrCl <70 mL/min/1.73 m²: one-half of the usual adult dose

Steady state takes longer; dialysis needs individualized supplementation.

Other indications / formulations

Epilepsy doses and extended-release schedules differ

The epilepsy maximum does not apply to migraine prevention.

Before prescribing

Check pregnancy plans, kidney function, serum bicarbonate, stone/glaucoma history, mood and cognitive demands. Review hormonal contraception, valproate and other carbonic-anhydrase inhibitors. Counsel on fetal harm and effective contraception; pregnancy is a prompt reassessment, not an unsupervised abrupt withdrawal.

Side effects and return precautions

Paresthesias, cognitive slowing, weight loss and taste changes; metabolic acidosis, stones, acute angle closure, reduced sweating and suicidal thoughts. Eye symptoms require prompt discontinuation and urgent assessment. Review hydration in the patient’s clinical context.

Follow-up

Practical review in 2–4 weeks during titration; assess migraine days and function after a sufficient tolerated trial. Baseline and periodic bicarbonate/renal review; taper planned discontinuation.

Sources

Checked September 20, 2026.

Tramadol IR (Ultram)Short-term severe pain

What to say

Because the other options haven’t adequately controlled this severe pain, we’ve chosen a short course of immediate-release tramadol. Take 50 milligrams every six hours only if needed, no more than four tablets a day, through [stop or review date]. This is an opioid and can cause dependence and overdose.

It can cause nausea, constipation and sleepiness. Don’t drive, drink alcohol or add sedatives. We need to check antidepressants and all your other medicines because tramadol has important interactions. Stop it and get emergency care for fever with agitation, shaking or stiff muscles. Call 911 for a seizure, slow breathing or someone who is hard to wake. Use naloxone for suspected opioid overdose while help is coming. Keep it locked away. We’ll reassess within a few days. Contact us before increasing it or extending the course.

Clinical reference

Dose options

Short immediate-release course

50 mg every 6 hours as needed; maximum 200 mg/day for this course

For rapid relief after a benefit/risk assessment; not a default for mild pain.

Label titration / ceiling

When rapid relief is unnecessary, start 25 mg/day and titrate gradually; usual subsequent 50–100 mg every 4–6 hours as needed

Maximum 400 mg/day; over age 75, maximum 300 mg/day. Higher limits are not treatment goals.

Organ impairment

CrCl <30: every 12 hours, maximum 200 mg/day; severe hepatic impairment: 50 mg every 12 hours

Do not substitute an extended-release formulation into this schedule.

Before prescribing

Check PDMP, renal/hepatic function, seizure history, respiratory risks, pregnancy, sedatives, serotonergic medicines and CYP2D6/CYP3A4 interactions. Offer naloxone.

Side effects and return precautions

Respiratory depression, addiction, seizures and serotonin syndrome; tramadol is not a low-risk substitute for other opioids.

Follow-up

Review pain, function and adverse effects within days for acute use, before any extension. Plan a taper when regular use has produced physical dependence.

Sources

Checked September 20, 2026.

Tranexamic acid (Lysteda)Heavy menstrual bleeding

What to say

Tranexamic acid slows the breakdown of blood clots in the uterus, making periods about a third lighter on average. It isn’t a hormone or birth control. Once your period starts, take 2 tablets, 1,300 milligrams in all, 3 times a day for up to 5 days. Never take more than 6 tablets a day. If you miss a dose, take it when you remember, then wait at least 6 hours before the next.

Headache, back pain and a stuffy nose are common. Don’t combine it with estrogen birth control, such as the pill, patch or ring, because clot risk rises. Stop it and call 911 for chest pain, sudden breathlessness, throat tightness, a drooping face, arm weakness or trouble speaking. Stop it and get same-day care for a painful, swollen leg or any vision change. Call the same day if you soak a pad hourly for several hours; call 911 if you faint. We’ll review it after 2 periods.

Clinical reference

Dose options

Cyclic heavy menstrual bleeding, normal renal function

1,300 mg (two 650-mg tablets) orally three times daily for up to 5 days during menstruation

Start once bleeding begins; maximum 3,900 mg/day; swallow whole. Missed dose: take it, then wait ≥6 hours; never more than 2 tablets at once.

Renal impairment (by serum creatinine)

SCr >1.4–2.8 mg/dL: 1,300 mg twice daily; >2.8–5.7: 1,300 mg once daily; >5.7: 650 mg once daily

Each for up to 5 days per cycle. The label adjusts by serum creatinine rather than eGFR; >95% is excreted unchanged in urine.

  • Label trials: 3,900 mg/day cut measured blood loss by 38–39% (placebo 5–12%). Not indicated for postmenopausal bleeding.

Before prescribing

Confirm cyclic HMB; exclude pregnancy and endometrial pathology. Contraindicated: combined hormonal contraception, active or prior thrombosis (including retinal occlusion), thrombophilia or thrombogenic cardiac disease. Check creatinine and CBC/ferritin; avoid with factor IX complex concentrates or ATRA.

Side effects and return precautions

Headache, sinus congestion, back, abdominal and musculoskeletal pain. Venous/arterial thrombosis and retinal vein/artery occlusion: stop and refer visual symptoms for dilated eye exam. Severe allergy; rare ligneous conjunctivitis.

Follow-up

Review blood loss, daily function and side effects after 2 cycles; stop if ineffective and reconsider the cause and options (LNG-IUD, hormonal therapy). Continue while beneficial; recheck CBC/ferritin if anemic.

Sources

Checked October 15, 2026.

Trazodone (Desyrel)Depression

What to say

For your depression, we’re starting trazodone at a total of 150 milligrams a day, divided as [written dose schedule]. Take each dose shortly after food. It can make you sleepy, so we’ll decide how to place the larger dose in the evening if needed.

Sleepiness, dry mouth and dizziness when standing are common. Avoid alcohol and see how it affects you before driving. Call the same day for worsening thoughts of self-harm, marked agitation or unusually high energy with little sleep. If you can’t stay safe, call 911. For fainting, call 911. A new irregular heartbeat needs same-day urgent care, and an erection lasting four hours means stop trazodone and go to the emergency department. We’ll check in within one to two weeks about safety and side effects. Mood benefit takes longer. Don’t stop suddenly without a plan.

Clinical reference

Dose options

Depression, immediate-release tablet

150 mg/day orally in divided doses initially; may increase by 50 mg/day every 3–4 days

Outpatient maximum 400 mg/day divided; titrate more slowly or start lower when clinical context warrants.

Sedation / schedule

Take shortly after a meal or light snack; a larger portion may be taken at bedtime

Specify actual tablet strengths and divided doses; avoid mixing immediate-release and extended-release schedules.

Insomnia use

Low-dose bedtime use is off-label; 50 mg has been studied

AASM and VA/DoD guidance recommend against routine use for chronic insomnia. Assess causes and use CBT-I first; an individualized exception needs its own benefit-risk and follow-up plan.

Before prescribing

Assess bipolar disorder, suicide risk, falls/orthostasis, QT/conduction risk, serotonergic and CYP3A4 drugs, MAOIs and bleeding risk. Renal/hepatic impairment is not well studied; use caution.

Side effects and return precautions

Sedation, orthostasis, dry mouth; arrhythmia, priapism, hyponatremia, serotonin syndrome and activation/suicidality. Provide a clear response to dangerous symptoms.

Follow-up

Review mood/safety within 1–2 weeks based on age/risk, then effectiveness over weeks. Assess daytime impairment and orthostasis; taper planned discontinuation.

Sources

Checked September 20, 2026.

Trazodone (Desyrel)Insomnia, off-label

What to say

Cognitive behavioral therapy for insomnia, called CBT-I, is the first-choice treatment for ongoing sleep trouble, and its benefits tend to last. While you work on it, we’re trying low-dose trazodone off-label. It’s an antidepressant, and the evidence that it helps sleep is limited. Take [25 or 50 milligrams] at bedtime. Don’t take more during the night. We’ll stop it if it isn’t clearly helping.

Morning grogginess, dizziness, headache and dry mouth are common. Stand up slowly, especially at night, because dizziness can cause falls. Avoid alcohol and other sleep medicines with it, and don’t drive if you feel drowsy. An erection lasting more than four hours means stop trazodone and go to the emergency department. Fainting means call 911. A new racing or irregular heartbeat needs same-day urgent care. Call the same day for thoughts of self-harm; if you might act on them, call 911. Check with us before starting other antidepressants or migraine medicines.

Clinical reference

Dose options

Off-label insomnia, adults

25–50 mg at bedtime; commonly 50–100 mg (AAFP 2017)

No labeled insomnia dose. The AASM recommendation rests on one 50-mg trial with small benefit and more headache and somnolence. Use a time-limited trial alongside CBT-I; tablets are scored for 25 mg.

Dose cautions

Older or frail adults, hepatic or renal impairment: 25 mg, titrate cautiously; strong CYP3A4 inhibitors: lower dose or avoid

Label: caution in older adults and organ impairment (not well studied); torsade de pointes reported at ≤100 mg. CYP3A4 inducers lower levels. Taper after regular use rather than stopping abruptly.

  • Off-label: AASM 2017 suggests against trazodone for sleep-onset or sleep-maintenance insomnia (weak) because harms may outweigh small benefits.

Before prescribing

Assess insomnia causes (sleep apnea, RLS, depression, substances, circadian) and offer CBT-I. Check bipolar history, suicide risk (boxed warning under 25), QT risk (QT drugs, CYP3A4 inhibitors, heart disease), falls, MAOIs/serotonergic drugs and sedatives.

Side effects and return precautions

Next-day sedation, orthostatic dizziness, falls, headache. Priapism ≥4 hours is an emergency. QT prolongation/arrhythmia, serotonin syndrome, hyponatremia (older adults, diuretics), bleeding with antithrombotics, activation or suicidality.

Follow-up

Review sleep diary, daytime function, falls and morning sedation in 2–4 weeks; stop if no clear benefit. Keep CBT-I central and avoid open-ended refills. Taper after prolonged nightly use.

Sources

Checked October 15, 2026.

Tretinoin 0.025% cream (Retin-A)Acne

What to say

For your acne, apply a thin layer of tretinoin 0.025% cream to the whole acne-prone area once at bedtime. Gently wash first and wait twenty to thirty minutes until the skin is completely dry. Keep it away from the eyes, lips and creases beside your nose. Using more will increase irritation rather than make it work faster.

Dryness, peeling or stinging can happen, and acne can look worse early on. Use a gentle moisturizer and sunscreen, and avoid scrubs or other irritating acne products unless we have planned the combination. Stop and contact us for severe redness, swelling, blistering or persistent irritation. We can change the frequency. Don’t use it during pregnancy or while trying to become pregnant. If pregnancy occurs, stop and contact us. Improvement takes weeks, so we’ll review results at about twelve weeks, sooner if irritation is troublesome.

Clinical reference

Dose options

Acne

0.025% cream: thin layer once nightly

Apply to acne-prone skin after washing and letting it dry; the label specifies a 20–30-minute wait.

Tolerability adjustment

Less-frequent use or a temporary pause when irritation warrants

Individualize vehicle/strength and combination therapy. Do not interchange cosmetic tretinoin, acne products or oral tretinoin instructions.

Before prescribing

Review pregnancy/plans, eczema, sunburn and irritating topical products. Topical retinoids should be avoided in pregnancy/planning pregnancy; acne severity may require combination or different treatment.

Side effects and return precautions

Early peeling/erythema are common; severe or persistent inflammation warrants interruption. Counsel sun protection and avoid application on actively eczematous or sunburned skin.

Follow-up

Review tolerability early if needed and the acne plan at about 12 weeks. Improvement may take over six weeks; do not escalate simply because early lesions persist.

Sources

Checked September 20, 2026.

Triamcinolone 0.1% cream (Kenalog, Triderm)Eczema flare on the body

What to say

For this eczema flare on your [body area], apply a thin film of triamcinolone 0.1% cream twice a day for [number of days]. It reduces the redness and itching. Rub it in gently, use only on the areas we identified, and keep using your plain moisturizer.

Don’t put it on your face, groin, underarms or broken skin unless we specifically agree on that use, and don’t cover it with a tight dressing. Brief burning or dryness can happen. Stop and contact us if irritation is strong or worsening. Call the same day for spreading redness, warmth, pus or fever because an infection may need different treatment. Repeated or prolonged use can thin the skin, so stop at the agreed endpoint and contact us if the rash persists or quickly returns. We’ll review it on [date].

Clinical reference

Dose options

Eczema on the body

0.1% cream: thin film twice daily

Specify body site and course; the label allows two to three applications daily but gives no course length.

Strength/site selection

Choose potency and vehicle for the site and diagnosis

Other strengths, ointment, dental paste and nasal/inhaled products are different prescriptions; avoid automatic facial or intertriginous use.

Before prescribing

Confirm steroid-responsive dermatitis; exclude untreated fungal/bacterial infection. Review site, surface area, prior steroid use and occlusion. Provide amount/site/duration instructions.

Side effects and return precautions

Local irritation and skin atrophy; extensive, prolonged or occluded use increases systemic absorption. Assess infection or treatment failure instead of extending automatically.

Follow-up

Arrange a course-end skin review or clear contact point; stop once controlled according to the written plan and reassess frequent relapse.

Sources

Checked September 20, 2026.

Trimethoprim/sulfamethoxazole (Bactrim, Septra)Purulent skin infection

What to say

For this skin infection, we’ve chosen trimethoprim/sulfamethoxazole because the suspected or tested bacteria are susceptible. Take [one or two] double-strength tablets twice daily for [number] days, as written on your prescription. If there’s a pocket of pus, drainage is often the most important treatment. Antibiotics don’t replace it. Keep the area covered as directed and avoid sharing towels.

Nausea can happen. Stop it and call the same day for a new rash. Blistering or mouth sores with a rash needs emergency care. Trouble breathing or tongue swelling means call 911. Get same-day advice for spreading redness, fever or worsening pain. Severe pain, rapid spread or feeling very ill needs emergency assessment. We’ll check the wound within two to three days and review any culture result.

Clinical reference

Dose options

Purulent skin infection / MRSA

1–2 DS tablets twice daily in adult IDSA regimens

Dose by weight, severity and renal function; duration depends on infection and response. Drainage may be the key treatment. Not a routine stand-alone choice for nonpurulent streptococcal cellulitis.

Label renal adjustment

CrCl >30: usual regimen; 15–30: half the usual regimen; <15: not recommended

Use an indication-specific regimen; do not apply the cystitis duration to another infection.

Before prescribing

Check sulfonamide/trimethoprim allergy, pregnancy, renal function, potassium and interactions, especially ACE inhibitor/ARB, spironolactone, warfarin and methotrexate. G6PD deficiency and blood disorders change risk. Assess need for drainage, culture and systemic care. Not routine monotherapy for nonpurulent streptococcal cellulitis; add or select streptococcal coverage when indicated.

Side effects and return precautions

GI upset, hyperkalemia, creatinine changes, marrow toxicity and serious skin reactions. Stop for rash and assess promptly; blistering/mucosal or systemic features need emergency assessment.

Follow-up

Recheck the wound and culture in 48–72 hours, earlier for worsening. Tailor duration to drainage, severity and response; do not copy the three-day cystitis course. Arrange early potassium/creatinine and CBC when risk or duration warrants.

Sources

Checked September 22, 2026.

Trimethoprim/sulfamethoxazole (Bactrim, Septra)Uncomplicated cystitis

What to say

I’m prescribing trimethoprim/sulfamethoxazole for this bladder infection. Take one double-strength tablet twice a day for three days. Each tablet contains 160 milligrams of trimethoprim and 800 milligrams of sulfamethoxazole. Take it with water and follow your usual fluid plan.

Nausea can happen. Stop it and call the same day for a new rash. A blistering rash or mouth sores with rash means go to the emergency department. Trouble breathing or tongue swelling means stop it and call 911. Call if symptoms aren’t improving within two days, or sooner for fever, side or back pain, or vomiting. This medicine can interact with other medicines and raise potassium, so we’ll check whether you need blood tests.

Clinical reference

Dose options

Uncomplicated cystitis

One DS tablet (160/800 mg) orally twice daily for 3 days

For nonpregnant women when the isolate is susceptible or local resistance is <20%.

Label renal adjustment

CrCl >30: usual regimen; 15–30: half the usual regimen; <15: not recommended

Use an indication-specific regimen; do not apply the cystitis duration to another infection.

Before prescribing

Check sulfonamide/trimethoprim allergy, pregnancy, renal function, potassium and interactions, especially ACE inhibitor/ARB, spironolactone, warfarin and methotrexate. G6PD deficiency and blood disorders change risk.

Side effects and return precautions

GI upset, hyperkalemia, creatinine changes, marrow toxicity and serious skin reactions. Stop for rash and assess promptly; blistering/mucosal or systemic features need emergency assessment.

Follow-up

Cystitis: reassess no improvement within 48 hours and review culture. Potassium/creatinine and sometimes CBC monitoring depend on risk and duration; arrange early labs for high-risk combinations.

Sources

Checked September 22, 2026.

Ubrogepant (Ubrelvy)Acute migraine

What to say

Ubrogepant treats a migraine attack. It works differently from triptans, so it’s an option when those don’t help or aren’t safe for you. Take [50 or 100] milligrams when the migraine starts, with or without food. If the headache continues or returns, you may take a second dose 2 or more hours later, up to 200 milligrams in 24 hours. Grapefruit juice and some antibiotics, antifungals and seizure medicines change its level, so check before starting anything new.

Nausea and sleepiness can happen. Check your blood pressure in the first week and tell us if it’s higher than usual. Fingers or toes that turn white or blue and hurt mean stop it and call us. Call 911 for face or throat swelling or trouble breathing, which can start days after a dose, or for a sudden severe headache, weakness or trouble speaking. If you need it on more than 8 days a month, let’s discuss prevention.

Clinical reference

Dose options

Acute migraine

50 or 100 mg orally at onset; may repeat once ≥2 hours later; maximum 200 mg/24 h

Not for prevention. Safety of treating more than 8 migraines in 30 days is not established.

CYP3A4 and transporter interactions

Strong CYP3A4 inhibitors (ketoconazole, itraconazole, clarithromycin): contraindicated. Moderate inhibitors (fluconazole, ciprofloxacin, cyclosporine, fluvoxamine, grapefruit juice): 50 mg, no second dose within 24 h

Weak CYP3A4 or BCRP/P-gp-only inhibitors: 50 mg, may repeat 50 mg. Strong inducers (rifampin, phenytoin, barbiturates, St. John’s wort): avoid. Weak/moderate inducers: 100 mg doses.

Renal / hepatic

CrCl 15–29 mL/min or Child-Pugh C: 50 mg, may repeat 50 mg; CrCl <15 mL/min: avoid

No adjustment for mild–moderate renal or hepatic impairment.

  • Unlike triptans, the label has no vascular contraindication; AHS 2021 consensus positions gepants for patients with triptan contraindications, intolerance or inadequate triptan response. The label now warns of hypertension and Raynaud phenomenon.

Before prescribing

Confirm migraine and why a gepant fits (triptan contraindication, intolerance or poor response). Check BP and hypertension history, Raynaud phenomenon, prior hypersensitivity, CYP3A4 inhibitors/inducers, CrCl, severe hepatic impairment, pregnancy plans and coverage.

Side effects and return precautions

Nausea, somnolence, dry mouth. Hypersensitivity, sometimes delayed; new or worsened hypertension, most often within 7 days of starting; Raynaud phenomenon (median onset 1.5 days with gepants). Stop for Raynaud or serious hypersensitivity.

Follow-up

Review response and BP after 2–3 treated attacks with a headache/medication diary. Frequent or disabling attacks, or treating more than 8 days a month, should prompt a prevention plan.

Sources

Checked October 15, 2026.

Ulipristal (ella)Emergency contraception

What to say

After sex without birth control or a birth control failure, take 1 ulipristal 30 milligram tablet, ella, as soon as possible within 5 days, with or without food. It works better than over-the-counter Plan B on days 3–5 and may work better at a higher body weight. If you vomit within 3 hours, call us about another dose. It won’t end an existing pregnancy or protect you if you have sex again.

Hormonal birth control can weaken ella, so wait 5 days before starting or restarting pills, the patch or the ring. Use condoms or avoid sex until you’ve been on that method for 7 days. Headache, nausea, cramps or tiredness can happen, and your period may come early or late. Take a pregnancy test if it’s more than a week late. Severe lower belly pain, especially 3–5 weeks later, needs emergency care. Seizure medicines, rifampin and St. John’s wort can reduce its effect.

Clinical reference

Dose options

Emergency contraception

Ulipristal acetate 30 mg orally once, as soon as possible within 120 hours

Prescription only. Any time in the cycle, with or without food. If vomiting within 3 hours, consider repeating the dose.

Starting hormonal contraception afterward

Start no sooner than 5 days after ulipristal; condoms or abstinence for 7 days after starting or until next menses, whichever comes first

Wording follows CDC SPR 2024; the label advises a barrier until the next period. Clinic-placed methods (DMPA, implant, IUD) may start at the visit after weighing reduced ulipristal effect; nonhormonal methods anytime.

  • Breastfeeding: the current US label reports infant exposure of about 1% of the maternal dose over 5 days and does not require stopping breastfeeding.

Before prescribing

Exclude known pregnancy (contraindicated). Review CYP3A4 inducers (e.g., carbamazepine, phenytoin, oxcarbazepine, topiramate, barbiturates, rifampin, St. John’s wort); offer a Cu-IUD instead. Label advises against repeat use in 1 cycle and against levonorgestrel EC within 5 days after.

Side effects and return precautions

Headache, abdominal pain, nausea, dysmenorrhea, fatigue and dizziness. Menses can shift; 19% were over 7 days late. Evaluate severe lower abdominal pain 3–5 weeks later for ectopic pregnancy.

Follow-up

Pregnancy test if menses are over a week late or absent at 3 weeks. Arrange ongoing contraception and an advance prescription. Offer STI testing; assess nPEP within 72 hours of HIV exposure.

Sources

Checked October 15, 2026.

Umeclidinium/vilanterol (Anoro Ellipta)COPD

What to say

Anoro Ellipta has 2 long-acting medicines that keep your airways open, easing breathlessness and reducing flare-ups. Take 1 inhalation once a day at the same time. It isn’t a rescue inhaler, so keep albuterol with you. Slide the cover down until it clicks; don’t shake it. Breathe out away from the mouthpiece. Seal your lips around it and take 1 long, steady, deep breath without covering the air vent. Hold your breath for 3–4 seconds, then close the cover.

Don’t add other long-acting inhalers, such as Spiriva, Trelegy, Advair or Symbicort. Sore throat or constipation can happen. Stop it and call us before the next dose for eye pain, blurred vision, halos around lights, trouble passing urine or a racing heartbeat. If eye pain is severe or you can’t pass urine, go to the emergency department. If breathing worsens right after a dose, use albuterol, stop Anoro and call us. Severe breathing trouble or chest pain means call 911.

Clinical reference

Dose options

COPD maintenance

Umeclidinium 62.5 mcg/vilanterol 25 mcg: 1 inhalation once daily

No more than once in 24 hours. No adjustment for age, renal impairment or moderate hepatic impairment. Discard 6 weeks after opening the foil tray.

Missed dose

Take when remembered, then resume the usual time

Never 2 inhalations in 1 day; don’t use extra doses for symptoms.

Before prescribing

Confirm COPD on spirometry and GOLD group B or E, where LABA+LAMA is initial therapy. Not for asthma. Review severe milk-protein allergy, narrow-angle glaucoma, BPH or retention, arrhythmia, duplicate LAMA/LABA or anticholinergics and strong CYP3A4 inhibitors.

Side effects and return precautions

Paradoxical bronchospasm, acute angle closure, urinary retention, tachyarrhythmia, hypokalemia and hyperglycemia, hypersensitivity. Caution with MAOIs, TCAs, QT-prolonging drugs, beta-blockers and non-potassium-sparing diuretics.

Follow-up

Review technique, adherence, symptoms and exacerbations at each visit. For exacerbations on LABA+LAMA, GOLD 2026 adds ICS if eosinophils ≥100, otherwise roflumilast or azithromycin. Rising rescue use needs prompt review.

Sources

Checked October 15, 2026.

Vaginal estradiol (Vagifem, Yuvafem)Genitourinary symptoms of menopause

What to say

Low-dose vaginal estradiol can help dryness, irritation and pain related to the tissue changes after menopause. With this 10-microgram product, insert one dose into the vagina each day for two weeks, then use one dose twice a week on [two separated days]. Let’s review the applicator instructions together.

Improvement usually builds over several weeks. Mild irritation or discharge can happen. This local treatment is different from hormone treatment for hot flashes. Contact us promptly for any new bleeding after menopause. Don’t assume it’s just from the medicine. We’ll review comfort and benefit in about six to twelve weeks. Tell me about any breast cancer history or treatment so we can make that decision together with the relevant team.

Clinical reference

Dose options

10-microgram vaginal tablet/insert

One insert vaginally daily for 2 weeks, then twice weekly

Use two separated maintenance days; verify the exact product/applicator.

Other vaginal estrogen products

Creams, rings and other inserts have different doses and schedules

Do not convert milligrams of cream to this tablet schedule without checking the product.

Ongoing treatment

Individualize by response; no automatic upward titration or universal course limit

Periodic review. Low-dose vaginal estrogen alone does not routinely require progestogen or endometrial surveillance solely because of use.

Before prescribing

Assess unexplained bleeding, diagnosis, contraindications and estrogen-sensitive cancer history. Breast cancer/aromatase inhibitor use needs individualized shared decision-making, often with oncology.

Side effects and return precautions

Local irritation/discharge; evaluate all new postmenopausal bleeding. Heavy bleeding with weakness/faintness requires emergency care. Do not promise zero systemic absorption.

Follow-up

Practical symptom/tolerance review in 6–12 weeks, then periodically. Continue based on benefit and shared decision; persistent symptoms warrant reconsidering the diagnosis.

Sources

Checked September 20, 2026.

Valacyclovir (Valtrex)Cold sores

What to say

At the first tingling or burning of a cold sore, take valacyclovir 2 grams, then another 2 grams twelve hours later. That’s the whole one-day course. Don’t keep taking it for several days. It can shorten the episode but doesn’t remove the virus. Avoid kissing, oral sex and sharing items that touch the sore while symptoms are present.

Headache or nausea can happen. Follow your usual fluid plan and call the same day if you can’t drink or are passing much less urine. Stop and go to the emergency department for confusion or hallucinations. Call 911 for a seizure. Tell us about kidney disease or new medicines before taking it.

Clinical reference

Dose options

Cold sores

2 g orally, then 2 g 12 hours later; one day only

Start at the first tingling, itching or burning. Reduce according to the cold-sore renal dosing table.

Kidney function

Reduce dose or frequency using this indication’s label renal table

Confirm CrCl and dialysis timing; do not use the shingles adjustment table for these HSV schedules.

Before prescribing

Confirm HSV diagnosis, indication, immune status, renal function, hydration and interacting/nephrotoxic drugs. Pregnancy and immunocompromise require a specific plan. Neurologic disease, severe illness or inability to urinate needs urgent assessment.

Side effects and return precautions

Headache/nausea; kidney injury and neurotoxicity with dehydration, renal impairment or excessive dosing. Severe headache, confusion or urinary retention requires urgent assessment.

Follow-up

Reassess frequent or atypical cold sores and eye symptoms promptly.

Sources

Checked September 22, 2026.

Valacyclovir (Valtrex)First genital herpes episode

What to say

For this first genital herpes episode, take valacyclovir 1 gram twice daily for ten days. It helps the sores heal and reduces symptoms but doesn’t remove the virus from your body. We’ll also discuss pain relief. Avoid sex while you have sores or warning symptoms. Condoms reduce but don’t eliminate transmission, and passing the virus can occur even without visible sores.

Headache or nausea can happen. Follow your usual fluid plan and call the same day if you can’t drink or are passing much less urine. Stop and go to the emergency department for confusion or hallucinations. Call 911 for a seizure. Tell us about kidney disease or new medicines before taking it.

Clinical reference

Dose options

First genital herpes episode

1 g orally twice daily for 7–10 days

The wording above uses the labeled 10-day course; CDC permits 7–10 days and extension if healing is incomplete.

Kidney function

Reduce dose or frequency using this indication’s label renal table

Confirm CrCl and dialysis timing; do not use the shingles adjustment table for these HSV schedules.

Before prescribing

Confirm HSV diagnosis, indication, immune status, renal function, hydration and interacting/nephrotoxic drugs. Pregnancy and immunocompromise require a specific plan. Neurologic disease, severe illness or inability to urinate needs urgent assessment.

Side effects and return precautions

Headache/nausea; kidney injury and neurotoxicity with dehydration, renal impairment or excessive dosing. Severe headache, confusion or urinary retention requires urgent assessment.

Follow-up

Review healing and pain; reassess persistent or atypical lesions, urinary difficulty or systemic symptoms. Discuss episodic versus suppressive treatment according to recurrence burden and preferences.

Sources

Checked September 22, 2026.

Valacyclovir (Valtrex)Genital herpes suppression

What to say

To reduce repeated genital herpes outbreaks, take valacyclovir 1 gram every day, even when you have no symptoms. It can reduce outbreaks but doesn’t remove the virus or eliminate transmission. Avoid sex during sores or warning symptoms and use condoms to lower risk. We’ll review each year whether daily treatment still fits your needs.

Headache or nausea can happen. Follow your usual fluid plan and call the same day if you can’t drink or are passing much less urine. Stop and go to the emergency department for confusion or hallucinations. Call 911 for a seizure. Tell us about kidney disease or new medicines before taking it.

Clinical reference

Dose options

Genital herpes suppression

1 g orally once daily; 500 mg daily is an alternative for selected patients

500 mg daily may be less effective with ≥10 episodes/year. The wording above uses 1 g; HIV/immunocompromised regimens differ.

Kidney function

Reduce dose or frequency using this indication’s label renal table

Confirm CrCl and dialysis timing; do not use the shingles adjustment table for these HSV schedules.

Before prescribing

Confirm HSV diagnosis, indication, immune status, renal function, hydration and interacting/nephrotoxic drugs. Pregnancy and immunocompromise require a specific plan. Neurologic disease, severe illness or inability to urinate needs urgent assessment.

Side effects and return precautions

Headache/nausea; kidney injury and neurotoxicity with dehydration, renal impairment or excessive dosing. Severe headache, confusion or urinary retention requires urgent assessment.

Follow-up

Review recurrence burden, transmission concerns, adherence and need for ongoing suppression at least annually.

Sources

Checked September 22, 2026.

Valacyclovir (Valtrex)Recurrent genital herpes episode

What to say

For another genital herpes outbreak, start valacyclovir 500 milligrams twice daily for three days as soon as you notice the familiar tingling or sores. Keep the prescription available so you can start promptly. It treats this episode. It isn’t a daily prevention schedule. Avoid sex during warning symptoms or sores. Condoms help but don’t eliminate transmission.

Headache or nausea can happen. Follow your usual fluid plan and call the same day if you can’t drink or are passing much less urine. Stop and go to the emergency department for confusion or hallucinations. Call 911 for a seizure. Tell us about kidney disease or new medicines before taking it.

Clinical reference

Dose options

Recurrent genital herpes episode

500 mg orally twice daily for three days

Start within one day of lesion onset or during the prodrome; provide advance access to treatment.

Kidney function

Reduce dose or frequency using this indication’s label renal table

Confirm CrCl and dialysis timing; do not use the shingles adjustment table for these HSV schedules.

Before prescribing

Confirm HSV diagnosis, indication, immune status, renal function, hydration and interacting/nephrotoxic drugs. Pregnancy and immunocompromise require a specific plan. Neurologic disease, severe illness or inability to urinate needs urgent assessment.

Side effects and return precautions

Headache/nausea; kidney injury and neurotoxicity with dehydration, renal impairment or excessive dosing. Severe headache, confusion or urinary retention requires urgent assessment.

Follow-up

Review healing and pain; reassess persistent or atypical lesions, urinary difficulty or systemic symptoms. Discuss episodic versus suppressive treatment according to recurrence burden and preferences.

Sources

Checked September 22, 2026.

Valacyclovir (Valtrex)Shingles

What to say

For this shingles episode, take valacyclovir 1 gram three times a day for seven days. It works best when started early. Take it with or without food and follow your usual fluid plan so you don’t become dehydrated.

Headache or nausea can happen. Call the same day if you can’t drink normally or are passing much less urine. For new confusion or hallucinations, stop valacyclovir and go to the emergency department. For a seizure, call 911. If the rash is near your eye or you have eye pain or vision changes, get same-day urgent eye care. Sudden vision loss means go to the emergency department. We’ll also make a pain-control plan and review how you’re doing.

Clinical reference

Dose options

Herpes zoster

1 g orally three times daily for 7 days

Begin as early as possible, preferably within 72 hours of rash onset; assess later presentations individually.

Renal adjustment: shingles

CrCl 30–49: 1 g every 12 hours; 10–29: 1 g daily; <10: 500 mg daily

Other HSV regimens have their own renal table. Hemodialysis timing matters.

Before prescribing

Check indication, onset, immune status, kidney function, hydration and nephrotoxic drugs. Ophthalmic, disseminated or neurologic disease may need urgent specialist/inpatient treatment.

Side effects and return precautions

Headache/nausea; kidney injury and neurotoxicity, especially with renal impairment or excessive dosing. Explain infection-specific transmission precautions; antivirals do not eliminate HSV transmission.

Follow-up

Review within a week for pain, healing and complications; earlier for rash near the eye, eye pain, vision changes or neurologic symptoms. Discuss covering lesions and avoiding susceptible high-risk contacts until crusted.

Sources

Checked September 22, 2026.

Valsartan (Diovan)Heart failure

What to say

For your heart-failure plan, start valsartan 40 milligrams twice daily. This schedule is morning and evening, with or without food. It helps reduce strain on the heart. We’ll check your blood pressure, kidney function and potassium before gradually increasing the dose. This is valsartan alone. Don’t add it to a medicine that already contains valsartan.

Lightheadedness can happen, especially if you become dehydrated. Call the same day if vomiting or diarrhea prevents you from drinking normally. We’ll tell you whether to hold it and when to restart. Don’t add potassium supplements or potassium salt substitutes without checking. If you become pregnant, stop valsartan and contact us immediately. Swelling of the lips or tongue or trouble breathing means stop it and call 911. We’ll check kidney function and potassium in about two weeks and review your blood pressure within a month.

Clinical reference

Dose options

Heart failure

40 mg twice daily, titrating toward 160 mg twice daily as tolerated

Different schedule from hypertension. This entry is valsartan alone, not sacubitril/valsartan.

Renal / hepatic considerations

No routine adjustment for mild/moderate renal or hepatic impairment

Severe renal impairment <30 mL/min/1.73 m² lacks established safety/effectiveness in label; severe liver disease has no dosing recommendation. Assess volume depletion first.

Before prescribing

Check BP, creatinine/eGFR, potassium, pregnancy plans and medication list. Avoid duplicate ACE/ARB therapy; aliskiren with diabetes is contraindicated. Review NSAIDs, lithium and potassium-raising products. Confirm the HFrEF role and absence of sacubitril/valsartan; titrate only when clinically stable.

Side effects and return precautions

Dizziness, hyperkalemia and renal injury may occur; face/tongue swelling needs emergency care. Fetal toxicity requires immediate discontinuation if pregnancy occurs. Provide a specific dehydration hold/restart plan when appropriate.

Follow-up

Review BP, heart-failure symptoms, weight, potassium and creatinine after starting and each titration, usually within 1–2 weeks depending on risk. Titrate toward 160 mg twice daily as tolerated; reassess congestion or hypotension before increasing.

Sources

Checked September 22, 2026.

Valsartan (Diovan)Heart failure or reduced heart function after a heart attack

What to say

Valsartan is part of your treatment after the heart attack because your heart’s pumping function was affected. It helps reduce strain on the heart and improves survival in this setting. Continue the tablet dose on your discharge list twice daily. We’ll review blood pressure, kidney function and potassium before increasing it.

Call if dizziness is persistent or vomiting or diarrhea prevents normal drinking. Check before adding potassium, salt substitutes or anti-inflammatory pain medicines. Don’t take an extra valsartan tablet with sacubitril/valsartan, which already contains it. Stop valsartan and call immediately if pregnancy occurs. Stop it and call 911 for swelling of the lips or tongue or trouble breathing. New chest pain, fainting or severe breathlessness also needs 911.

Clinical reference

Dose options

Stable adult post-MI initiation

20 mg twice daily; may increase to 40 mg twice daily within 7 days, then toward 160 mg twice daily as tolerated

The label permits initiation as early as 12 hours after MI in monitored acute care. At follow-up use the discharge regimen; do not restart the initial sequence.

Tolerability and formulation

Reduce or reassess dosing for symptomatic hypotension or renal dysfunction

Tablet and oral-suspension exposures differ; do not substitute milligram for milligram.

Before prescribing

Confirm post-MI LV dysfunction/failure, stability and cardiology plan. Check BP, creatinine, potassium, pregnancy and volume status. Avoid duplicate ACE inhibitor/ARB/ARNI therapy; aliskiren with diabetes is contraindicated. Review NSAIDs, lithium and potassium-raising drugs.

Side effects and return precautions

Hypotension, kidney injury and hyperkalemia. Angioedema needs emergency assessment. Provide individualized dehydration and laboratory follow-up instructions.

Follow-up

Agree an early post-discharge review; a practical plan is BP and creatinine/potassium within 1–2 weeks and after dose changes, sooner for higher risk. Track symptoms with cardiology.

Sources

Checked September 23, 2026.

Valsartan (Diovan)Hypertension

What to say

I’m starting valsartan 80 milligrams once a day for your blood pressure. Take it at a consistent time, with or without food. It lowers pressure even when you don’t feel anything happening. Keep a record of your home readings so we can decide whether the dose is right.

Lightheadedness can happen, especially if you become dehydrated. Call the same day if vomiting or diarrhea prevents you from drinking normally. We’ll tell you whether to hold it and when to restart. Don’t add potassium supplements or potassium salt substitutes without checking. If you become pregnant, stop valsartan and contact us immediately. Swelling of the lips or tongue or trouble breathing means stop it and call 911. We’ll check kidney function and potassium in about two weeks and review your blood pressure within a month.

Clinical reference

Dose options

Hypertension

80 or 160 mg orally once daily initially; range 80–320 mg daily

Choose start by BP and volume status. Much effect appears within 2 weeks; maximal effect generally by 4 weeks.

Renal / hepatic considerations

No routine adjustment for mild/moderate renal or hepatic impairment

Severe renal impairment <30 mL/min/1.73 m² lacks established safety/effectiveness in label; severe liver disease has no dosing recommendation. Assess volume depletion first.

Before prescribing

Check BP, creatinine/eGFR, potassium, pregnancy plans and medication list. Avoid duplicate ACE/ARB therapy; aliskiren with diabetes is contraindicated. Review NSAIDs, lithium and potassium-raising products.

Side effects and return precautions

Dizziness, hyperkalemia and renal injury may occur; face/tongue swelling needs emergency care. Fetal toxicity requires immediate discontinuation if pregnancy occurs. Provide a specific dehydration hold/restart plan when appropriate.

Follow-up

Creatinine/potassium in 2–4 weeks after initiation or titration, earlier with renal/volume risk. Review home BP around 2–4 weeks; the wording above uses two-week labs.

Sources

Checked September 22, 2026.

Vancomycin capsules or solution (Firvanq, Vancocin)C. difficile infection

What to say

This treats C. diff, a bowel infection that often follows antibiotics. Swallowed vancomycin stays in the gut, where the infection is. Take 125 milligrams four times a day, spread through the day, for 10 days, even if you feel better sooner. Store the liquid form as labeled. Tell us about any other antibiotics; we’ll stop them if it’s safe. Don’t take loperamide or other anti-diarrhea medicines unless we say so.

Nausea or belly pain can happen. Wash your hands with soap and water, not just sanitizer, after using the toilet and before eating, and clean the bathroom with a product labeled to kill C. diff. Call the same day if you aren’t improving within a few days or can’t keep up with fluids. Stop it and get same-day care for a new rash, blisters or mouth sores. Severe belly pain or swelling, fever, fainting or very little urine means go to the emergency department. If diarrhea returns after treatment, call us.

Clinical reference

Dose options

Initial episode, nonfulminant

125 mg orally four times daily for 10 days

Label and ACG 2021 regimen. IDSA/SHEA 2021 suggests fidaxomicin 200 mg twice daily for 10 days instead when available, because recurrences are fewer; vancomycin remains acceptable.

Recurrence

Fidaxomicin (standard or extended-pulsed) or a vancomycin taper/pulse, e.g., 125 mg four times daily 10–14 days, twice daily 1 week, daily 1 week, then every 2–3 days for 2–8 weeks

IDSA/SHEA 2017 and 2021, ACG 2021. FMT for multiple recurrences; Rebyota or Vowst can prevent further recurrence after antibiotic treatment of a recurrence.

Fulminant CDI (hospital care)

500 mg orally every 6 hours, with IV metronidazole; rectal vancomycin if ileus

Severe: WBC ≥15,000/mm³ or creatinine >1.5 mg/dL. Fulminant adds hypotension, shock, ileus or megacolon (ACG 2021).

  • IDSA/SHEA 2021 prefers fidaxomicin when available; check price and coverage for both drugs before prescribing.

Before prescribing

Test only with ≥3 unformed stools in 24 hours. Classify severity (WBC, creatinine). Stop inciting antibiotics if possible, review PPI need, avoid cholestyramine with vancomycin, and check renal function if older than 65.

Side effects and return precautions

Nausea, abdominal pain, hypokalemia; nephrotoxicity (higher risk over 65, during or after treatment); occasional significant serum levels; SJS/TEN/DRESS. Distension, ileus, hypotension or rising WBC suggest fulminant disease.

Follow-up

Confirm improvement within a few days; recheck renal function after treatment if older than 65. No test of cure. About 20% recur within 8 weeks; retest only for new diarrhea.

Sources

Checked October 15, 2026.

Varenicline (Chantix)Smoking cessation

What to say

Varenicline reduces nicotine cravings and makes smoking less rewarding. Start 0.5 milligrams once a day for three days, then 0.5 milligrams twice a day for four days. Starting on day eight, take 1 milligram twice a day. Take it after food with a full glass of water. We’ll write down the day-by-day dose schedule and your quit date and arrange support for cravings.

Nausea and vivid dreams are common. Tell me if they’re troublesome, because a lower dose may help. Cut back on alcohol until you know how this affects you, and see how you feel before driving. Stop it and call the same day for a major change in mood or behavior, suicidal thoughts or sleepwalking. If you can’t stay safe or have a seizure, call 911. We’ll check in around your quit date and review the plan over the usual twelve-week course.

Clinical reference

Dose options

Standard start

Days 1–3: 0.5 mg orally daily; days 4–7: 0.5 mg twice daily; day 8 onward: 1 mg twice daily

Begin one week before the quit date, or choose a quit date between days 8 and 35.

Duration / intolerance

Usually 12 weeks; another 12 weeks may help maintain abstinence

Reduce the dose for adverse effects. A gradual-reduction-to-quit approach uses a different 24-week plan.

Renal impairment

CrCl <30: start 0.5 mg daily, maximum 0.5 mg twice daily; hemodialysis maximum 0.5 mg daily if tolerated

Standard maximum 1 mg twice daily; assess renal function, especially in older adults.

Before prescribing

Review kidney function, prior serious varenicline reaction, mood/suicide risk, seizure history, alcohol and pregnancy/breastfeeding. Arrange counseling/quitline support and a quit date. Smoking cessation itself can change levels of medicines such as clozapine/theophylline.

Side effects and return precautions

Nausea, sleep changes and vivid dreams. Stop and assess serious behavioral changes, sleepwalking or seizure; severe allergic swelling or blistering rash requires emergency care.

Follow-up

Practical contact around the quit date or within 1–2 weeks, then reassess smoking, adherence, mood, tolerance and need for continuation. A lapse is a reason to adjust support, not abandon treatment.

Sources

Checked September 20, 2026.

Venlafaxine XR (Effexor XR)Depression

What to say

I’m starting extended-release venlafaxine for depression. Take 37.5 milligrams with breakfast for seven days, then 75 milligrams each morning if you’re tolerating it. Swallow the capsule whole. This is a daily treatment, and improvement takes several weeks. Nausea, sweating, dry mouth, sleep changes, or sexual side effects can happen.

Missing doses or stopping suddenly can cause dizziness and an electric-shock feeling, so call before you run out. Don’t double a missed dose. We’ll check your blood pressure and how you’re feeling within two weeks. Call the same day for marked agitation, unusually little need for sleep, or thoughts of harming yourself. If you can’t stay safe, call 911 or go to the emergency department. Stop it and go to the emergency department for fever with confusion and shaking or stiff muscles. We’ll plan any later dose reduction together.

Clinical reference

Dose options

Depression

37.5 mg daily for 4–7 days, then 75 mg daily; maximum 225 mg/day

75 mg may be used initially. Label permits increases ≤75 mg at intervals ≥4 days; individualize a slower titration when appropriate.

Renal / hepatic reduction

CrCl 30–89: reduce 25–50%; CrCl <30 or dialysis: reduce ≥50%

Child-Pugh A/B: reduce 50%; Child-Pugh C/cirrhosis: reduce ≥50%. Individualize and taper gradually when stopping.

  • Effexor XR capsules may be opened onto applesauce and swallowed immediately without chewing; follow the dispensed product’s instructions.

Before prescribing

Check BP before starting and control hypertension. Assess renal/hepatic function, bipolar disorder, suicide risk, serotonergic medicines, bleeding and sodium risk. MAOI spacing: 14 days before venlafaxine, 7 days after stopping it.

Side effects and return precautions

Withdrawal can occur with missed doses; avoid abrupt cessation. Monitor sustained hypertension, activation and sexual effects. Serotonin syndrome or imminent self-harm danger requires emergency assessment.

Follow-up

Review within 2 weeks, or 1 week at age 18–25/higher suicide risk. Check BP with titration and periodically; assess response, tolerability, refill access and need for a slower taper.

Sources

Checked September 22, 2026.

Venlafaxine XR (Effexor XR)Generalized anxiety disorder

What to say

For persistent anxiety, start extended-release venlafaxine 37.5 milligrams with breakfast for seven days, then 75 milligrams each morning if tolerated. It’s taken daily, and improvement builds over weeks. We’ll track worry, tension and how anxiety affects daily life. Swallow the capsule whole. Nausea, sweating, sleep changes or sexual side effects can happen.

Missing doses or stopping suddenly can cause dizziness and an electric-shock feeling, so call before you run out. Don’t double a missed dose. We’ll check your blood pressure and how you’re feeling within two weeks. Call the same day for marked agitation, unusually little need for sleep, or thoughts of harming yourself. If you can’t stay safe, call 911 or go to the emergency department. Stop it and go to the emergency department for fever with confusion and shaking or stiff muscles. We’ll plan any later dose reduction together.

Clinical reference

Dose options

Generalized anxiety disorder

37.5 mg daily for 4–7 days, then 75 mg daily; maximum 225 mg/day

75 mg may be used initially. Label permits increases ≤75 mg at intervals ≥4 days; individualize a slower titration when appropriate.

Renal / hepatic reduction

CrCl 30–89: reduce 25–50%; CrCl <30 or dialysis: reduce ≥50%

Child-Pugh A/B: reduce 50%; Child-Pugh C/cirrhosis: reduce ≥50%. Individualize and taper gradually when stopping.

  • Effexor XR capsules may be opened onto applesauce and swallowed immediately without chewing; follow the dispensed product’s instructions.

Before prescribing

Check BP before starting and control hypertension. Assess renal/hepatic function, bipolar disorder, suicide risk, serotonergic medicines, bleeding and sodium risk. MAOI spacing: 14 days before venlafaxine, 7 days after stopping it.

Side effects and return precautions

Withdrawal can occur with missed doses; avoid abrupt cessation. Monitor sustained hypertension, activation and sexual effects. Serotonin syndrome or imminent self-harm danger requires emergency assessment.

Follow-up

Review within 2 weeks, or 1 week at age 18–25/higher suicide risk. Check BP with titration and periodically; assess response, tolerability, refill access and need for a slower taper.

Sources

Checked September 22, 2026.

Venlafaxine XR (Effexor XR)Panic disorder

What to say

For panic disorder, start extended-release venlafaxine 37.5 milligrams with breakfast for seven days, then 75 milligrams each morning if tolerated. This is daily prevention, not immediate treatment for an attack. We’ll track the frequency of attacks and activities you avoid. Swallow the capsule whole. Nausea, sweating or sleep changes can happen early.

Missing doses or stopping suddenly can cause dizziness and an electric-shock feeling, so call before you run out. Don’t double a missed dose. We’ll check your blood pressure and how you’re feeling within two weeks. Call the same day for marked agitation, unusually little need for sleep, or thoughts of harming yourself. If you can’t stay safe, call 911 or go to the emergency department. Stop it and go to the emergency department for fever with confusion and shaking or stiff muscles. We’ll plan any later dose reduction together.

Clinical reference

Dose options

Panic disorder

37.5 mg daily for seven days, then 75 mg daily; maximum 225 mg/day

If needed, increase by ≤75 mg at intervals of at least seven days; use response and tolerability.

Renal / hepatic reduction

CrCl 30–89: reduce 25–50%; CrCl <30 or dialysis: reduce ≥50%

Child-Pugh A/B: reduce 50%; Child-Pugh C/cirrhosis: reduce ≥50%. Individualize and taper gradually when stopping.

  • Effexor XR capsules may be opened onto applesauce and swallowed immediately without chewing; follow the dispensed product’s instructions.

Before prescribing

Check BP before starting and control hypertension. Assess renal/hepatic function, bipolar disorder, suicide risk, serotonergic medicines, bleeding and sodium risk. MAOI spacing: 14 days before venlafaxine, 7 days after stopping it.

Side effects and return precautions

Withdrawal can occur with missed doses; avoid abrupt cessation. Monitor sustained hypertension, activation and sexual effects. Serotonin syndrome or imminent self-harm danger requires emergency assessment.

Follow-up

Review within 2 weeks, or 1 week at age 18–25/higher suicide risk. Check BP with titration and periodically; assess response, tolerability, refill access and need for a slower taper.

Sources

Checked September 22, 2026.

Venlafaxine XR (Effexor XR)Social anxiety disorder

What to say

For social anxiety, take extended-release venlafaxine 75 milligrams each morning with food. Take it every day rather than just before a social situation. We’ll track how anxiety and avoidance affect your activities over the next several weeks. Swallow the capsule whole. Nausea, sweating, sleep changes or sexual side effects can happen.

Missing doses or stopping suddenly can cause dizziness and an electric-shock feeling, so call before you run out. Don’t double a missed dose. We’ll check your blood pressure and how you’re feeling within two weeks. Call the same day for marked agitation, unusually little need for sleep, or thoughts of harming yourself. If you can’t stay safe, call 911 or go to the emergency department. Stop it and go to the emergency department for fever with confusion and shaking or stiff muscles. We’ll plan any later dose reduction together.

Clinical reference

Dose options

Social anxiety disorder

75 mg orally once daily with food

Higher doses did not show additional benefit for social anxiety; use the indication-specific recommended dose.

Renal / hepatic reduction

CrCl 30–89: reduce 25–50%; CrCl <30 or dialysis: reduce ≥50%

Child-Pugh A/B: reduce 50%; Child-Pugh C/cirrhosis: reduce ≥50%. Individualize and taper gradually when stopping.

  • Effexor XR capsules may be opened onto applesauce and swallowed immediately without chewing; follow the dispensed product’s instructions.

Before prescribing

Check BP before starting and control hypertension. Assess renal/hepatic function, bipolar disorder, suicide risk, serotonergic medicines, bleeding and sodium risk. MAOI spacing: 14 days before venlafaxine, 7 days after stopping it.

Side effects and return precautions

Withdrawal can occur with missed doses; avoid abrupt cessation. Monitor sustained hypertension, activation and sexual effects. Serotonin syndrome or imminent self-harm danger requires emergency assessment.

Follow-up

Review within 2 weeks, or 1 week at age 18–25/higher suicide risk. Check BP with titration and periodically; assess response, tolerability, refill access and need for a slower taper.

Sources

Checked September 22, 2026.

Vilazodone (Viibryd)Depression

What to say

For depression, take vilazodone once a day with a meal: 10 milligrams for 7 days, then 20 milligrams. We may later raise it to 40 milligrams. Always take it with food, or much less is absorbed. If you miss a dose, take it when you remember unless the next dose is almost due; never take 2 at once. Benefits build over several weeks.

Diarrhea and nausea are common, and poor sleep, dizziness or sexual side effects can happen; tell us if they’re a problem. Call the same day for worsening thoughts of self-harm, marked agitation or unusually high energy with very little sleep. If you might act on those thoughts, call 911; 988 can provide crisis support. Go to the emergency department for fever with confusion, shaking or stiff muscles. Check with us before starting antibiotics, antifungals, mood or migraine medicines, tramadol, blood thinners or daily ibuprofen. Don’t stop suddenly; we’ll taper.

Clinical reference

Dose options

Adult depression

10 mg orally once daily with food for 7 days, then 20 mg once daily with food

May increase to 40 mg after ≥7 days; target 20–40 mg/day. Fasting lowers AUC about 50% and Cmax about 60%. No adjustment for age or for mild–severe renal or hepatic impairment.

CYP3A4 interactions

Strong CYP3A4 inhibitor (itraconazole, clarithromycin, voriconazole): maximum 20 mg/day; resume the prior dose when it stops

Strong inducer (carbamazepine, phenytoin, rifampin) >14 days: consider up to 2× the dose (maximum 80 mg/day) over 1–2 weeks; reduce back over 1–2 weeks after the inducer stops.

Stopping

From 40 mg: 20 mg daily for 4 days, then 10 mg daily for 3 days. From 20 mg: 10 mg daily for 7 days

Label taper; slow it further if withdrawal symptoms appear (NICE). MAOIs: 14 days before starting and after stopping.

  • SSRI plus 5-HT1A partial agonist; generic. VA/DoD lists it among first-line options, none superior. It must be taken with food and titrated (unlike sertraline or escitalopram), and diarrhea is common; a reasonable switch after SSRI failure or intolerance.

Before prescribing

Screen suicidality, bipolar/mania history, seizures, narrow angles, sodium and bleeding risk (NSAIDs, antiplatelets, anticoagulants), pregnancy plans. Contraindicated: MAOIs within 14 days, linezolid, IV methylene blue. Review strong CYP3A4 inhibitors/inducers; check a digoxin level before co-use.

Side effects and return precautions

Diarrhea (26–29% vs 10% placebo), nausea, vomiting, insomnia, dizziness, sexual dysfunction. Serotonin syndrome, bleeding (monitor INR on warfarin), hyponatremia, seizures, angle closure, mania, suicidality. Recheck digoxin levels.

Follow-up

Review within 2 weeks (1 week if 18–25 or higher suicide risk); if response is partial, consider 40 mg after ≥1 week at 20 mg. Judge response over 6–12 weeks; continue ≥6 months after remission; taper to stop.

Sources

Checked October 21, 2026.

Vonoprazan (Voquezna)Erosive esophagitis and heartburn

What to say

Vonoprazan is a strong acid blocker that works differently from PPIs like omeprazole. It starts working quickly, and you can take it with or without food at any time of day. Swallow it whole. To heal erosive esophagitis, damage to the food pipe, take 20 milligrams once a day for 8 weeks; 10 milligrams a day may then keep it healed. For heartburn without that damage, take 10 milligrams daily for 4 weeks. Take a missed dose within 12 hours; otherwise skip it.

Diarrhea, nausea or belly pain can happen. Call us for watery diarrhea that won’t stop, much less urine or a new rash; blistering skin or mouth sores mean go to the emergency department. Trouble swallowing, repeated vomiting or weight loss needs prompt review, and vomiting blood or black stools needs emergency care. Tell us about HIV medicines, seizure medicines and clopidogrel; rilpivirine can’t be combined with it.

Clinical reference

Dose options

Erosive esophagitis

Healing: 20 mg once daily for 8 weeks; maintenance: 10 mg once daily for up to 6 months

Healing dose with eGFR <30 or Child-Pugh B/C: 10 mg daily; no change for maintenance. AGA 2024: may be used for LA grade C/D, though not routinely first-line given cost; generally not first-line for LA A/B.

Nonerosive reflux heartburn

10 mg once daily for 4 weeks

AGA 2024: generally not first-line for NERD or uninvestigated heartburn; consider after failure of twice-daily PPI.

Interactions and testing

Contraindicated with rilpivirine; avoid atazanavir, nelfinavir and strong or moderate CYP3A4 inducers

CYP2C19 inhibition may reduce clopidogrel effect; weak CYP3A inhibitor; lowers absorption of pH-dependent drugs. Stop ≥4 weeks before chromogranin A testing.

Before prescribing

Confirm EE grade or typical NERD and screen for alarm features; AGA 2024 favors PPIs first except in severe EE or PPI failure. Check rilpivirine, atazanavir/nelfinavir, CYP3A4 inducers, clopidogrel, renal/hepatic function and coverage.

Side effects and return precautions

Gastritis, diarrhea, abdominal pain or distension, nausea. Acid-suppression risks: C. difficile, fractures, B12 deficiency, hypomagnesemia, fundic gland polyps; interstitial nephritis and SJS/TEN reported. Response doesn’t exclude gastric cancer.

Follow-up

Reassess at the end of the course; stop NERD treatment after 4 weeks. After EE healing, decide on maintenance (label: up to 6 months) or step-down; check magnesium with prolonged use plus diuretics or digoxin.

Sources

Checked October 15, 2026.

Vonoprazan with amoxicillin (Voquezna Dual Pak)H. pylori infection

What to say

This treatment clears H. pylori, a stomach infection that can cause ulcers and cancer. It pairs vonoprazan, a strong acid reducer, with the antibiotic amoxicillin for 14 days. Each morning and evening, take one 20-milligram vonoprazan tablet and two amoxicillin capsules, 1,000 milligrams. At midday, take two more amoxicillin capsules. Food doesn’t matter. If you miss a dose, take it within 4 hours; otherwise skip it. Don’t take it if you’re allergic to penicillin.

Diarrhea, belly pain, headache and vaginal yeast infections can happen. Stop it and call the same day for a rash or hives. Get emergency care for blistering skin, lip or tongue swelling, or trouble breathing. Call promptly for severe or bloody diarrhea, even weeks later. Tell us about all your medicines, especially HIV medicines, clopidogrel, warfarin, seizure medicines and St. John’s wort. We’ll retest at least 4 weeks after you finish; stop acid reducers 2 weeks before that test.

Clinical reference

Dose options

H. pylori, treatment-naive adult without penicillin allergy

Vonoprazan 20 mg twice daily + amoxicillin 1,000 mg three times daily for 14 days

FDA-approved co-pack; with or without food. ACG 2024 suggests PCAB dual therapy as a first-line option (conditional, moderate evidence). Missed dose: take within 4 hours, otherwise skip.

Renal and hepatic limits

Not recommended if eGFR <30 mL/min or Child-Pugh B or C

Per label; choose another regimen, such as bismuth quadruple therapy.

Before prescribing

Exclude β-lactam allergy and mononucleosis. Contraindicated with rilpivirine; avoid strong/moderate CYP3A inducers, atazanavir and nelfinavir. Review clopidogrel (CYP2C19), warfarin, allopurinol, pH-dependent drugs, eGFR, liver disease and coverage.

Side effects and return precautions

Diarrhea/C. difficile, hypersensitivity and SCAR, drug-induced enterocolitis, acute interstitial nephritis, vulvovaginal candidiasis. Chromogranin A rises; measure ≥4 weeks after treatment.

Follow-up

Test of cure ≥4 weeks after therapy with PPI/PCAB held 2 weeks (PCAB effect on testing not well studied). Persistent infection: bismuth quadruple therapy if not used, or susceptibility-guided therapy.

Sources

Checked October 15, 2026.

Vortioxetine (Trintellix)Depression

What to say

For depression, take vortioxetine 10 milligrams once a day, with or without food. If you’re tolerating it, we’ll usually raise it to 20 milligrams after about a week. Benefits build over several weeks. Nausea is the most common side effect; it’s usually mild or moderate and often settles within about 2 weeks. Constipation, vomiting and sexual side effects can also happen; tell us rather than stopping on your own.

Call the same day for worsening thoughts of self-harm, marked agitation or unusually high energy with very little sleep. If you might act on those thoughts, call 911; 988 can provide crisis support. Go to the emergency department for fever with confusion, shaking or stiff muscles. Check with us before starting bupropion, fluoxetine or paroxetine (they raise vortioxetine levels), other mood or migraine medicines, tramadol, blood thinners or daily ibuprofen. Don’t stop suddenly; we’ll lower the dose first.

Clinical reference

Dose options

Adult depression

10 mg orally once daily, with or without food; increase to 20 mg daily as tolerated

VA/DoD titrates by 5–10 mg weekly. Maximum 20 mg/day (higher doses not studied); 5 mg/day if higher doses aren’t tolerated. No label adjustment for age or renal/hepatic impairment; VA/DoD lists a 5–10 mg start for older adults.

CYP2D6 inhibitors and strong inducers

Known CYP2D6 poor metabolizer: maximum 10 mg/day. With a strong CYP2D6 inhibitor (bupropion, fluoxetine, paroxetine, quinidine): halve the dose

Restore the original dose when the inhibitor stops. Strong inducer (rifampin, carbamazepine, phenytoin) >14 days: consider increasing, up to 3× the original dose; return to it within 14 days of stopping the inducer.

Stopping

From 15–20 mg/day: 10 mg daily for 1 week, then stop

Label allows abrupt stopping but advises this step to limit headache and muscle tension; taper more slowly if withdrawal symptoms appear (NICE). MAOIs: 14 days after an MAOI before starting; 21 days after vortioxetine before an MAOI.

  • VA/DoD 2022 lists it among first-line options. Brand-only (no generic on DailyMed, October 2026). In a label trial, patients with SSRI sexual dysfunction improved more after switching to it than to escitalopram. Weight-neutral in trials.

Before prescribing

Screen suicidality and bipolar/mania history. Contraindicated with MAOIs (none within 14 days before or 21 days after), linezolid or IV methylene blue. Review CYP2D6 inhibitors (including bupropion), serotonergic drugs, NSAIDs/anticoagulants, sodium risk, narrow angles, pregnancy plans (limited human data) and baseline sexual function.

Side effects and return precautions

Dose-related nausea (median 2 weeks), constipation, vomiting, sexual dysfunction. Serotonin syndrome, bleeding, hyponatremia (older adults, diuretics), angle closure, mania, suicidality. False-positive urine methadone immunoassay; confirm by chromatography.

Follow-up

Review within 2 weeks (1 week if 18–25 or higher suicide risk); titrate to 20 mg as tolerated. Judge response over 6–12 weeks; continue ≥6 months after remission; step down to 10 mg for 1 week before stopping.

Sources

Checked October 21, 2026.

Warfarin (Jantoven)Anticoagulation when a DOAC isn’t suitable

What to say

Warfarin is a blood thinner adjusted with a blood test called the INR. Take it once a day, following your dosing calendar. Your INR goal is usually 2 to 3, higher with some mechanical valves. We’ll test often at first, then every 1 to 4 weeks once it’s steady. Don’t avoid leafy greens; just eat about the same amount each week. If you miss a dose, take it later that day, but never double up the next day.

Antibiotics, antifungals, amiodarone, aspirin, ibuprofen and many supplements affect warfarin; tell us before starting or stopping any medicine. Acetaminophen is the safer pain reliever, but daily use for several days can raise your INR. Call us the same day about repeated nosebleeds. Go to the emergency department for black stools, vomiting blood, or any fall or head injury. Call 911 for a sudden severe headache, bleeding that won’t stop or stroke symptoms. Warfarin can harm a pregnancy; use reliable birth control.

Clinical reference

Dose options

Starting dose (genotype unknown)

Usually 2–5 mg once daily; typical maintenance 2–10 mg daily, adjusted to INR

Lower doses for older or debilitated and Asian patients; routine loading doses are not recommended. INR frequently until stable in range, then every 1–4 weeks.

INR targets

2.0–3.0 for AF, VTE and most indications; 2.5–3.5 for mechanical mitral and caged-ball or caged-disk valves

Bileaflet or Medtronic Hall mechanical aortic valve in sinus rhythm without LA enlargement: 2.0–3.0 per label. Confirm the valve team’s target.

Procedures

Hold 5 days for a target INR <1.5 (2–3 days for INR <2); check INR before the procedure

Minimally invasive procedures may proceed with INR at the low end of range (label). For AF, no LMWH bridging unless mechanical valve or recent stroke/TIA (2023 guideline).

  • Contraindicated in pregnancy except mechanical valves at high thromboembolic risk; do not start during acute heparin-induced thrombocytopenia.

Before prescribing

Document why a DOAC is unsuitable (mechanical valve, moderate–severe rheumatic MS, triple-positive APS, interactions, cost). Check baseline INR, CBC, LFTs, pregnancy and contraception, falls, alcohol and interacting drugs. Boxed warning: major or fatal bleeding.

Side effects and return precautions

Bleeding, highest in the first month and with INR >4; skin necrosis (protein C/S deficiency), purple toes and calciphylaxis. INR shifts with antibiotics, azoles, amiodarone, diet, illness, acetaminophen and botanicals.

Follow-up

INR frequently until stable, then every 1–4 weeks, with extra checks after medicine, diet or health changes. Review bleeding, adherence and the indication; switch to a DOAC if one becomes appropriate.

Sources

Checked October 15, 2026.

Zoledronic acid (Reclast)Osteoporosis

What to say

To lower your chance of breaking a bone, you’ll get zoledronic acid, 5 milligrams through a vein once a year, over at least 15 minutes. We’ll check your kidney function and calcium before each dose. On the day, eat normally and drink at least 2 glasses of water in the few hours before, unless you’ve been told to limit fluids. Take calcium and vitamin D as we discuss. Finish needed dental work first if you can.

Within 3 days, many people get fever, aches, chills or a flu-like feeling, usually lasting a few days and less likely with later doses. Acetaminophen can help. Call us if symptoms last more than a week, you’re passing much less urine, or you have muscle cramps or tingling around your mouth. Tell us promptly about eye pain or redness, an irregular heartbeat, new thigh or groin pain, or a jaw sore that won’t heal. Call 911 for face or throat swelling or trouble breathing.

Clinical reference

Dose options

Osteoporosis treatment (postmenopausal women, men, glucocorticoid-induced)

5 mg IV over ≥15 minutes once yearly

Hydrate first; use a separate vented line with no calcium-containing fluids and a 10 mL saline flush. Acetaminophen after the infusion reduces acute-phase symptoms.

Postmenopausal osteoporosis prevention

5 mg IV over ≥15 minutes once every 2 years

Label: at least 1,200 mg calcium and 800–1,000 IU vitamin D daily, supplementing if diet falls short.

Kidney function

Contraindicated if CrCl <35 mL/min or acute kidney injury; no adjustment at CrCl ≥35

Calculate CrCl (Cockcroft-Gault, actual body weight) before every dose. Withhold if dehydrated; use caution with diuretics, NSAIDs and other nephrotoxins.

Before prescribing

Correct hypocalcemia and vitamin D deficiency first; check calcium and creatinine/CrCl before each dose. Not with Zometa (same drug). Review dental health, hypoparathyroidism, malabsorption, aspirin-sensitive asthma, fluid status and pregnancy potential.

Side effects and return precautions

Acute-phase reaction within 3 days, less with repeat doses; AKI; hypocalcemia; osteonecrosis of the jaw; atypical femur fracture (thigh or groin pain); atrial fibrillation; uveitis or scleritis; severe musculoskeletal pain; anaphylaxis.

Follow-up

Yearly infusions with pre-dose creatinine and calcium; DXA by risk. After 3 infusions, reassess: continue if still high risk, or consider a drug holiday if low-to-moderate, reassessing every 2–4 years (Endocrine Society).

Sources

Checked October 15, 2026.

Zolpidem IR (Ambien)Short-term insomnia

What to say

We’re using a short trial of immediate-release zolpidem while we address your insomnia with a sleep treatment plan, including cognitive behavioral therapy for insomnia. Take 5 milligrams only when needed, right before getting into bed, for up to seven nights before our review. Only take it when you have seven to eight hours available to sleep. Don’t take a second dose during the night or take it with or right after a meal.

Don’t take it after alcohol or combine it with other sedatives unless we have specifically reviewed them. It can leave you impaired the next morning, so don’t drive if you’re sleepy or not fully alert. If you sleepwalk, drive, eat, or do other things without being fully awake, stop it and call us immediately. Don’t try another dose. Slow breathing or being difficult to wake means call 911. We’ll reassess within a week rather than automatically refill it.

Clinical reference

Dose options

Immediate-release adult start

Women: 5 mg; men: 5 or 10 mg once immediately before bedtime

Choose lowest effective dose; maximum 10 mg/night. At least 7–8 hours before planned awakening; no redosing. Not Ambien CR or middle-of-night sublingual products.

Older / hepatic / renal

Older or debilitated adults: 5 mg; mild/moderate hepatic impairment: 5 mg

Avoid severe hepatic impairment. No routine renal dose adjustment; assess clinical vulnerability and interacting sedatives.

Duration / stopping

As short as possible; a 7-night trial with review

Evaluate persistent insomnia after 7–10 days. Dependence/withdrawal risk rises with exposure; longer established use may need a taper, except stop immediately for complex sleep behaviors.

Before prescribing

Assess insomnia cause, CBT-I access, sleep apnea/respiratory disease, falls, depression/suicide risk, substance use and sedatives/opioids. Prior complex sleep behavior with zolpidem is a contraindication. Review pregnancy and lactation.

Side effects and return precautions

Boxed warning: complex sleep behaviors can cause serious injury/death even with a first dose; stop immediately and contact clinician. Next-day impairment, amnesia and falls may occur. Respiratory depression or unresponsiveness requires 911.

Follow-up

Arrange review in 7–10 days or sooner for adverse effects; assess sleep benefit, daytime function and continued need. Document a stopping plan and continue CBT-I/underlying-cause management.

Sources

Checked September 20, 2026.

Vaccines

Influenza (flu) vaccineAnnual adult vaccination

What to say

I recommend a flu vaccine this season to lower your chance of flu and serious complications. You need a new dose each year because the viruses change and protection fades. This flu shot can’t give you flu. Protection takes about two weeks to build.

A sore arm, tiredness or aches for a day or two can happen. Tell us about a serious reaction to a previous flu vaccine or a history of Guillain-Barré syndrome. Afterward, call 911 for trouble breathing, swelling of your face or throat, or collapse. Contact us for other severe or persistent symptoms.

Clinical reference

Dose schedules

Adult annual schedule

One dose of the current-season, age-appropriate vaccine each year

For most adults, aim for September or October; continue offering vaccination while flu circulates.

Adults 65 years and older

Prefer high-dose inactivated, recombinant or adjuvanted influenza vaccine

If none is available, use another age-appropriate product rather than delay. Dose volume depends on the product; the wording above assumes an injectable vaccine.

Before vaccinating

Check current-season vaccination, age/product, prior severe vaccine/component allergy, moderate/severe acute illness and GBS within 6 weeks of a previous influenza vaccine. Egg allergy alone does not preclude an otherwise appropriate flu vaccine. Review pregnancy and immune status when choosing formulation; live nasal vaccine has additional restrictions.

Side effects and return precautions

Local pain and short-lived systemic symptoms are common. Severe allergy is rare; assess serious or persistent symptoms rather than attributing everything to vaccination.

Follow-up

Document the product/date and provide the current VIS. Return each season; no routine second seasonal dose for adults.

Sources

Checked September 24, 2026.

COVID-19 vaccineUpdated adult vaccination

What to say

An updated COVID vaccine helps lower your risk of severe illness. We’ll review your age, health conditions, earlier doses and any recent infection to choose the product and timing. Today you’ll get [vaccine]. [Next dose date, or no additional dose currently planned.]

A sore arm, fatigue, headache or fever can occur and usually settle within a few days. Heart inflammation is rare but needs prompt assessment: seek care for chest pain, shortness of breath or a racing heartbeat, especially during the following week. Call 911 for severe breathing trouble, facial or throat swelling, or collapse.

Clinical reference

Dose schedules

Adults 18–64 without moderate/severe immunocompromise

CDC 2026–2027 guidance: one current-season dose

After a prior dose: at least 8 weeks for Spikevax, Comirnaty or Nuvaxovid; at least 3 months for mNexspike. Verify product-specific eligibility and dose volume.

Adults 65 and older without moderate/severe immunocompromise

CDC 2026–2027 guidance: two current-season doses, usually 6 months apart

Minimum interval to second dose: 2 months, or 3 months for mNexspike. Verify prior-dose timing and the live CDC table before administration.

Moderate/severe immunocompromise

Use the separate current CDC schedule

Do not apply the routine adult schedule; prior series and treatment timing can change the plan.

  • Season-specific guidance checked September 24, 2026. CDC recommendations and FDA-labeled indications differ for some recipients/additional doses; confirm the current product label and discuss applicable off-label use.

Before vaccinating

Review vaccine/component allergy, prior myocarditis/pericarditis, immune status, recent infection and acute illness. Myocarditis/pericarditis within 3 weeks of a prior COVID dose generally warrants avoiding subsequent doses pending individualized assessment.

Side effects and return precautions

Common reactions resolve in 1–3 days. Rare myocarditis/pericarditis and anaphylaxis require prompt recognition.

Follow-up

Record product, formulation, date and next-dose plan. Recent infection may justify delaying a dose up to 3 months after symptom onset or a positive test, individualized to risk.

Sources

Checked September 24, 2026.

Pneumococcal vaccineAdult pneumonia and invasive disease prevention

What to say

This vaccine protects against strains of pneumococcal bacteria that can cause pneumonia and serious blood or brain infections. It doesn’t prevent every kind of pneumonia. Based on your age, health history and earlier vaccines, we’re giving you [PCV20 or PCV21]. With this vaccine, your pneumococcal vaccination is complete under current recommendations.

You may have a sore arm, fatigue or a mild fever afterward. Tell us about any severe reaction to an earlier vaccine. Call 911 for trouble breathing, face or throat swelling, or collapse. Contact us if other symptoms are severe or don’t settle.

Clinical reference

Dose schedules

No prior PCV / unknown history, eligible adult

One dose of PCV20 or PCV21; no PPSV23 afterward

Recommended for adults 50 and older and adults 19–49 with qualifying risk conditions.

PCV15 alternative, no prior pneumococcal vaccination

PCV15, then PPSV23 usually 1 year later

An 8-week minimum may be used for immunocompromise, CSF leak or cochlear implant. Prior pneumococcal doses change this schedule.

Before vaccinating

Verify all prior PCV/PPSV23 dates and risk factors using the current CDC algorithm. Review severe allergy to the vaccine/components, including diphtheria-toxoid-containing vaccines for PCVs, and moderate/severe acute illness. Do not apply the vaccine-naive schedule to a previously vaccinated adult.

Side effects and return precautions

Injection-site pain, fever, headache and fatigue can occur; serious allergic reactions are rare.

Follow-up

Document product/date and either completion or the next appointment. Recalculate the schedule if prior records emerge; pneumococcal vaccination is not annual.

Sources

Checked September 24, 2026.

Hepatitis A vaccine (Havrix, Vaqta)Adult prevention

What to say

Hepatitis A is a liver infection that can spread through contaminated food, water or close contact. This vaccine lowers your risk. We’ll give the first shot today and schedule the second for [date, at least six months later]. Completing both doses gives long-lasting protection.

A sore arm, headache or tiredness can happen. Call 911 for trouble breathing, face or throat swelling, or collapse after vaccination. If you have recently been exposed to hepatitis A or leave for travel very soon, tell us today. You may need a different prevention plan. Continue careful handwashing and food and water precautions.

Clinical reference

Dose schedules

Havrix, age 19 and older

1 mL IM now and 6–12 months later

Use adult formulation.

Vaqta, age 19 and older

1 mL IM now and 6–18 months later

Use adult formulation.

Combined hepatitis A/B option, age 18 and older

Twinrix: three doses at 0, 1 and 6 months

An accelerated travel schedule is available; select and document the full product-specific course.

Before vaccinating

Offer to adults requesting protection and those with indications such as travel, chronic liver disease, HIV, homelessness, drug use or sexual exposure risk. Check prior doses, severe allergy and acute illness. Recent exposure within 2 weeks or imminent travel requires prompt assessment for vaccine and possible immune globulin; Twinrix is not the post-exposure product.

Side effects and return precautions

Local soreness, fever, headache or fatigue; rare severe allergy.

Follow-up

Book the second dose. A delayed series generally does not need restarting; reconcile records and complete it. Healthy adults usually do not need post-vaccination antibody testing.

Sources

Checked September 24, 2026.

Hepatitis B vaccine (Heplisav-B, Engerix-B, Recombivax HB)Adult prevention

What to say

Hepatitis B can spread through blood and sexual contact and can cause lasting liver damage or liver cancer. We’ve chosen Heplisav-B: one shot today and another at least four weeks later on [date]. Other brands use a different schedule, so keep a record of which vaccine you receive.

We can also check whether you have ever had hepatitis B. Testing shouldn’t delay protection. The vaccine prevents infection but doesn’t treat an infection you already have. A sore arm, headache or fatigue can happen. Call 911 for breathing trouble, swelling of your face or throat, or collapse after vaccination.

Clinical reference

Dose schedules

Heplisav-B, age 18 and older

0.5 mL IM: two doses at least 4 weeks apart

The two-dose schedule requires two Heplisav-B doses. Hemodialysis requires a different product-specific plan.

Engerix-B / Recombivax HB

Three-dose series, usually at 0, 1 and 6 months

Use the age-appropriate formulation and dose; dialysis regimens differ. Check minimum intervals for catch-up.

Combined hepatitis A/B option

Twinrix, age 18 and older: 0, 1 and 6 months

Accelerated option: days 0, 7 and 21–30 plus a dose at 12 months.

Before vaccinating

Vaccinate unvaccinated adults 19–59; adults 60 and older with risk factors should receive it, and others seeking protection may receive it. Check records, severe yeast/component allergy, acute illness, renal/dialysis status and immune status. Offer once-in-adulthood HBsAg, anti-HBs and total anti-HBc screening without making testing a barrier. Recent exposure needs a separate urgent post-exposure plan.

Side effects and return precautions

Local pain, headache, fever or fatigue; rare severe allergy.

Follow-up

Book remaining doses; do not restart solely because of a delay. Most adults do not need antibody testing afterward; arrange anti-HBs 1–2 months after completion when indicated, such as for exposed healthcare personnel, dialysis or selected immunocompromised patients.

Sources

Checked September 24, 2026.

Zoster vaccine (Shingrix)Shingles prevention

What to say

Shingrix lowers your risk of shingles and the nerve pain that can last after the rash heals. It contains no live virus. You need two shots, even if you have had shingles before. We’ll give the first today and the second on [date, usually two to six months later].

A sore arm, fatigue, aches, chills or fever can be strong enough to interrupt your usual activities for two or three days. Those expected reactions usually don’t prevent you from getting the second dose. Call 911 for trouble breathing, facial or throat swelling, or collapse. Contact us for severe or persistent symptoms, and seek urgent care for new progressive weakness.

Clinical reference

Dose schedules

Routine adult series

Two IM doses, 2–6 months apart, for adults 50 and older

Vaccinate after the acute episode has resolved if shingles is currently present.

Immunocompromised adults 19 and older

Two doses; usual interval 2–6 months, or 1–2 months when a shorter course is beneficial

Coordinate with immunosuppressive therapy. If the second dose is late, give it without restarting.

Before vaccinating

Check eligibility, previous Shingrix/Zostavax doses, severe allergy, current shingles, acute illness and pregnancy. Wait at least 8 weeks after Zostavax. Shingrix does not treat active shingles or substitute for varicella vaccination; assess varicella immunity when indicated in immunocompromised adults.

Side effects and return precautions

Local and systemic reactions are common. Severe allergy is rare; GBS has been reported very rarely.

Follow-up

Schedule and document dose two. Reassess suspected severe allergy before another dose; routine temporary soreness or fever is not a reason to abandon the series.

Sources

Checked September 24, 2026.

Typhoid vaccine (Typhim Vi, Vivotif)Adult travel prevention

What to say

Your itinerary includes a risk of typhoid, an infection spread through contaminated food or water. We’ll give you the typhoid shot, ideally at least two weeks before you travel. It doesn’t protect everyone or prevent every cause of travel-related fever or diarrhea, so safe food, drinking water and handwashing still matter.

You may have soreness, headache or a mild fever after the shot. Call 911 for breathing trouble, facial or throat swelling, or collapse. If you develop a persistent fever during or after travel, seek medical care and tell the clinician where you traveled, even if you were vaccinated.

Clinical reference

Dose schedules

Injectable Vi polysaccharide: Typhim Vi

0.5 mL IM once, at least 2 weeks before exposure

Repeat every 2 years if risk continues.

Live oral Ty21a: Vivotif alternative

One capsule on days 0, 2, 4 and 6; finish at least 1 week before exposure

Refrigerate, do not freeze. Swallow whole with cool water about 1 hour before a meal and at least 2 hours after the last meal. Repeat the four-dose course every 5 years if risk continues.

Before vaccinating

Review destination, departure date, prior vaccine, pregnancy, immune status, severe allergy, acute febrile/GI illness, antibiotics and antimalarials. Avoid live Ty21a in pregnancy or immunocompromise. Separate Ty21a from antibiotics by more than 72 hours before and after; longer may be needed for long-acting agents. Start atovaquone-proguanil at least 10 days after the last capsule.

Side effects and return precautions

Injection-site symptoms with Typhim Vi; GI upset can occur with oral Ty21a. Neither vaccine guarantees protection or is licensed for paratyphoid prevention.

Follow-up

Document the route, completion deadline and future booster date. If oral doses are missed or travel is too soon, reassess the plan rather than assume full protection.

Sources

Checked September 24, 2026.

RSV vaccine (Arexvy, Abrysvo, mResvia)Adult severe disease prevention

What to say

RSV can cause a serious lung infection, especially with older age or certain health conditions. Because of [age or risk factor], I recommend one dose to lower your chance of severe illness. If you have already received an RSV vaccine, tell us: it isn’t currently a yearly vaccine, and another dose isn’t recommended.

A sore arm, fatigue, headache or muscle aches can happen. A rare nerve condition called Guillain-Barré syndrome has been linked to some RSV vaccines. We can discuss how that risk compares with your risk from RSV. Seek urgent care for new spreading weakness or trouble walking. Call 911 for trouble breathing, face or throat swelling, or collapse.

Clinical reference

Dose schedules

CDC adult recommendation

One IM dose for all adults 75 and older; adults 50–74 with increased risk

Arexvy, Abrysvo or mResvia; no preferred product. Confirm the current label and preparation instructions.

Timing / repeat doses

Any time of year; late summer to early fall is usually best

In most of the continental U.S., August–October. Do not repeat a prior RSV dose under current guidance.

  • Adult age/risk criteria follow the February 2026 clinical guidance; older VIS versions may still show the previous age threshold.

Before vaccinating

Verify no previous RSV vaccination, qualifying age/risk, severe allergy and acute illness. Risk includes significant heart/lung disease, immune compromise, frailty and nursing-home residence; isolated hypertension alone does not qualify. FDA licensure in younger adults is not the same as a CDC recommendation.

Side effects and return precautions

Local and systemic reactions; rare severe allergy. Safety monitoring has identified increased GBS risk with Arexvy/Abrysvo in older adults; discuss individual benefit and risk.

Follow-up

Record product/date. Recheck future guidance rather than automatically scheduling an annual booster.

Sources

Checked September 24, 2026.

MMR vaccine (M-M-R II, Priorix)Measles, mumps and rubella prevention

What to say

MMR protects against measles, mumps and rubella. We’ll check your records to see whether you need a dose. Most adults who need vaccination need one dose; some, including international travelers, college students and healthcare workers, need two. Your plan is [dose today and next dose date, if needed].

This is a live vaccine, so tell us if you are pregnant or take medicines that weaken your immune system. Avoid pregnancy for 28 days after vaccination. A sore arm, fever, mild rash or temporary joint aches can occur. Call 911 for trouble breathing, swelling of your face or throat, or collapse.

Clinical reference

Dose schedules

Most adults without evidence of immunity

One MMR dose

Review written vaccination records, laboratory evidence and birth year before deciding a dose is needed.

Adults at higher exposure risk

Two MMR doses at least 28 days apart

Includes international travelers, postsecondary students and healthcare personnel without evidence of immunity. Count valid prior doses toward the series.

  • Birth before 1957 generally counts as presumptive immunity, with additional considerations for healthcare personnel. A verbal vaccination history alone is insufficient.
  • MMR and varicella vaccines can be given on the same day; otherwise separate them by at least 28 days. Check product-specific intervals after antibody-containing blood products.
  • Use MMR for adults; the combined MMRV vaccine is licensed only for children ages 1–12.

Before vaccinating

Screen for pregnancy, severe immunodeficiency, immunosuppressive treatment, severe vaccine/component allergy, recent antibody-containing blood products, other live vaccines, thrombocytopenia and significant acute illness. HIV eligibility depends on immune status; use the specific CDC criteria rather than vaccinating during severe immunosuppression.

Side effects and return precautions

Expected reactions include soreness, fever, rash and transient joint symptoms, especially in adult women. Unusual bruising or bleeding needs prompt evaluation; severe allergic symptoms require emergency care.

Follow-up

Document doses and schedule any remaining dose. Routine antibody testing after vaccination is not recommended.

Sources

Checked October 1, 2026.

Meningococcal ACWY vaccine (Menveo, MenQuadfi)Risk-based adult vaccination

What to say

This vaccine helps prevent four groups of meningococcal bacteria that can cause meningitis or a dangerous bloodstream infection. We recommend it because of [your risk factor]. Your previous doses and reason for vaccination determine whether you need one dose, a series or a booster. Your plan is [schedule]. A separate vaccine covers group B, and we’ll check whether you need that too.

Your arm may be sore, and you may feel tired or have a headache. Call 911 for trouble breathing, facial or throat swelling, or collapse. Vaccination does not prevent every cause of meningitis.

Clinical reference

Dose schedules

Asplenia, HIV, complement deficiency or complement inhibitor treatment

Two doses at least 8 weeks apart

For adults starting the series. Give a booster 5 years after completion, then every 5 years while risk continues.

College residence halls, military, travel or laboratory exposure

Usually one dose when indicated; account for previous vaccination

First-year college students living in residence halls need a dose if none was given at age 16 or older. For ongoing travel or occupational risk, give boosters every 5 years.

  • For complement inhibitor treatment, coordinate both MenACWY and MenB vaccination, ideally completed or updated at least 2 weeks before therapy. Discuss additional antimicrobial prevention with the treating team; vaccines do not eliminate the risk.

Before vaccinating

Confirm the indication, prior doses, age-appropriate product, allergy history and acute illness. Check destination-specific travel requirements and public-health advice during outbreaks. Pregnancy does not preclude MenACWY when indicated.

Side effects and return precautions

Local pain, fatigue, muscle aches and headache can occur. Severe allergic reactions need emergency treatment. Complement inhibitor recipients remain at substantial risk despite vaccination and should seek immediate care for possible meningococcal symptoms.

Follow-up

Record the product and dose dates. Schedule the second dose or booster when indicated, and separately assess MenB eligibility.

Sources

Checked October 1, 2026.

Meningococcal B vaccine (Bexsero, Trumenba)Shared decision or increased risk

What to say

This vaccine protects against group B meningococcal bacteria, which can cause meningitis or a dangerous bloodstream infection. It covers a different group than MenACWY. For healthy young adults, we decide together whether its short-term protection is worthwhile. Certain health conditions or exposures make vaccination more important. Based on your situation, we recommend [plan]. The doses need to use the same vaccine brand.

A sore arm, tiredness, headache, muscle aches, fever or nausea can occur. Call 911 for trouble breathing, swelling of your face or throat, or collapse. Tell us if you are pregnant or breastfeeding before vaccination.

Clinical reference

Dose schedules

Shared decision-making for adults ages 18–23

Two doses at 0 and 6 months

Bexsero and Trumenba use the same timing. A 3-dose series at 0, 1–2 and 6 months can be used when more rapid protection is needed.

Adults at increased risk

Three doses at 0, 1–2 and 6 months

If dose two is at least 6 months after dose one, dose three is unnecessary. If dose three is less than 4 months after dose two, repeat it at least 4 months later unless it was at least 6 months after dose one.

Persistent increased risk

Booster 1 year after the primary series, then every 2–3 years

Use the same brand. Outbreak booster timing follows public-health guidance; healthy adults vaccinated by shared decision do not routinely need boosters.

  • When MenACWY and MenB are both due at the same visit, an age-appropriate MenABCWY product may be used. Penbraya contains the Trumenba component; Penmenvy contains the Bexsero component. Keep subsequent MenB doses consistent with that component. Separate MenABCWY doses by at least 6 months.

Before vaccinating

Identify asplenia, complement deficiency or inhibitor treatment, routine laboratory exposure, or a group B outbreak. HIV alone is not a MenB indication. Review prior brand, severe allergy and acute illness. Defer in pregnancy or breastfeeding unless increased risk makes the benefits outweigh potential risks.

Side effects and return precautions

Local and systemic reactions are common; severe allergy is rare. Protection is incomplete, particularly during complement inhibitor therapy.

Follow-up

Document the brand and schedule remaining doses. High-risk vaccination at age 26 or older and high-risk booster doses are ACIP-recommended off-label uses.

Sources

Checked October 1, 2026.

Varicella vaccine (Varivax)Chickenpox prevention

What to say

This vaccine prevents chickenpox. We’ll review your records and history to see whether you are already protected. Adults who need vaccination usually need two doses, four to eight weeks apart. If you already had one valid dose, we can complete the series. This is different from the shingles vaccine.

This is a live vaccine. Tell us if you are pregnant, have a weakened immune system or take medicines that suppress it. Avoid pregnancy for one month after each dose. A sore arm, fever or mild rash can occur. If a rash appears, call us and avoid contact with people who are not immune and are at high risk, such as pregnant or immunocompromised people, until it resolves. Call 911 for breathing trouble, facial or throat swelling, or collapse.

Clinical reference

Dose schedules

Adults without evidence of immunity

Two single-antigen varicella doses, 4–8 weeks apart

The minimum interval is 4 weeks. If dose two is late, give it without restarting.

One documented prior dose

Give one additional dose at least 4 weeks after the first

Count valid previous doses. Selected patients with immune compromise need a specific eligibility assessment and schedule rather than this routine plan.

  • Use single-antigen varicella vaccine for adults; MMRV is not licensed for adults. Shingrix does not replace this series.
  • Give MMR and varicella on the same day or at least 28 days apart; check timing after antibody-containing blood products.

Before vaccinating

Evidence includes two documented doses, laboratory evidence, or clinician-verified chickenpox or shingles. U.S. birth before 1980 generally counts, except for healthcare personnel, pregnant people and immunocompromised people. Screen for pregnancy, severe immunodeficiency, vaccine/component allergy and acute illness; review immunosuppressants, antivirals, salicylates, recent blood products and live vaccines.

Side effects and return precautions

Soreness, fever or a vaccine-related rash can occur. A rash warrants advice about avoiding susceptible high-risk contacts. Severe allergic symptoms require emergency care.

Follow-up

Record doses and arrange completion. Routine antibody testing after vaccination is not recommended because commercial tests can miss vaccine-induced immunity.

Sources

Checked October 1, 2026.

Tdap or Td vaccine (Boostrix, Adacel, Tenivac)Tetanus, diphtheria and whooping cough prevention

What to say

This shot protects against tetanus, diphtheria and whooping cough. Whooping cough can be deadly for young babies, so your shot helps protect the babies around you. Adults need 1 Tdap shot if they’ve never had one, then a tetanus booster every 10 years. After a deep or dirty wound or burn, you may need one sooner. We’ll give it today.

Your arm may be sore, red or swollen, and mild fever, headache or tiredness can happen. Before the shot, tell us if you’ve had Guillain-Barré syndrome or severe swelling after a tetanus shot. Call 911 for trouble breathing, facial or throat swelling, or collapse. Contact us for a high fever or symptoms lasting more than a few days.

Clinical reference

Dose schedules

Adults who never had Tdap

1 dose Tdap 0.5 mL IM, then Td or Tdap every 10 years

Boostrix is licensed for ages 10 and older and Adacel for 10–64; ACIP counts either as valid at 65 and older. Pregnancy: Tdap each pregnancy, preferably early in weeks 27–36.

Unvaccinated or incomplete primary series

Tdap, then Td or Tdap at least 4 weeks later, then Td or Tdap 6–12 months later

Give only the doses needed to complete 3 documented doses; boosters every 10 years after.

Wound management

With 3 or more prior doses: Td or Tdap if >10 years since the last dose (clean minor wound) or >5 years (all other wounds)

Unknown or fewer than 3 doses: vaccinate, and give TIG 250 IU IM for dirty or major wounds. With HIV or severe immunodeficiency, give TIG for any contaminated wound regardless of vaccine history. Tdap preferred if no prior Tdap. After an Arthus reaction, no tetanus vaccine more often than every 10 years, even for wounds.

  • Adult Tdap/Td recommendations are unchanged; a March 2026 federal court stay of the reconstituted ACIP’s votes is under appeal.

Before vaccinating

Check Tdap history and last dose. Contraindications: severe allergy to a dose or component; for Tdap, unexplained encephalopathy within 7 days of a pertussis vaccine (use Td). Precautions: GBS within 6 weeks of a tetanus dose; prior Arthus reaction.

Side effects and return precautions

Injection-site pain, redness and swelling are common; fever, headache and fatigue occur. Extensive limb swelling and anaphylaxis are rare. Overly frequent doses raise Arthus risk.

Follow-up

Record product and date in the chart and immunization registry; set a 10-year reminder. Reassess tetanus status at every wound visit.

Sources

Checked October 15, 2026.

HPV vaccine (Gardasil 9)HPV-related cancer prevention

What to say

This vaccine protects against the HPV types behind most cervical cancers, many anal and throat cancers, and genital warts. It works best before exposure but still protects against types you haven’t caught. It’s recommended through age 26; from 27 to 45, the benefit is smaller, so we decide together. You’ll get 3 shots: today, in 1–2 months and at 6 months. If you miss one, we continue rather than restart.

It doesn’t treat HPV you already have, and it doesn’t replace cervical screening. Your arm may be sore, red or swollen, and headache or mild fever can happen. Some people faint after shots, so you’ll sit for 15 minutes. If you’re pregnant, we’ll wait until after the pregnancy. Call 911 for trouble breathing, facial or throat swelling, or collapse.

Clinical reference

Dose schedules

Adults through 26 starting at 15 or older

3 IM doses at 0, 1–2 and 6 months

Minimum intervals: 4 weeks (dose 1 to 2), 12 weeks (2 to 3), 5 months (1 to 3); repeat a dose given too soon. Continue an interrupted series without restarting. Started at 9–14: 2 doses at least 5 months apart complete it.

Adults 27–45 after shared decision-making

3 IM doses at 0, 1–2 and 6 months (2 doses if started at 9–14)

Benefit is lower because many have prior exposure; most useful with likely new exposure, such as a new partner. Gardasil 9 is licensed through age 45.

Immunocompromising conditions, including HIV

3 doses at 0, 1–2 and 6 months, even if started at 9–14

Pregnancy: defer until after; no pregnancy test needed; no action if given inadvertently.

  • Adult HPV recommendations are unchanged; a federal court stayed HHS’s January 2026 childhood schedule memo in March 2026 (appeal pending).

Before vaccinating

Check age, prior doses and age at first dose, severe allergy to a prior dose or component (including yeast), pregnancy and acute illness. No Pap, HPV or antibody testing is needed first.

Side effects and return precautions

Injection-site pain, swelling and redness, headache and fever are common. Syncope, sometimes with seizure-like movements, occurs: vaccinate seated and observe 15 minutes. Anaphylaxis is rare.

Follow-up

Schedule and document remaining doses; continue rather than restart an interrupted series. Vaccination doesn’t change cervical screening; screen per age-based guidelines.

Sources

Checked October 15, 2026.

Mpox vaccine (Jynneos)Mpox prevention

What to say

This vaccine lowers your risk of mpox (monkeypox), and infections after vaccination tend to be milder. It’s made from a weakened virus that can’t cause mpox, and people living with HIV can get it. You need 2 shots, 4 weeks apart: the first today and the second on [date]. Protection peaks 2 weeks after the second. After an exposure, get it as soon as possible, ideally within 4 days.

Redness, swelling, itching or soreness at the shot site are common, as are tiredness, headache and muscle aches. Call 911 for trouble breathing or face or throat swelling. Get same-day care for chest pain or a racing heartbeat. Vaccination doesn’t make infection impossible, so keep using your other ways to lower risk.

Clinical reference

Dose schedules

Pre-exposure series, age 18 and older

0.5 mL subcut, 2 doses 28 days apart

Dose 2 may be given 24–35 days after dose 1; if later, give it without restarting. Peak immunity 14 days after dose 2.

Post-exposure prophylaxis

Start the series as soon as possible, ideally ≤4 days after exposure; days 4–14 may still help

After 14 days, decide case by case (e.g., severe immunosuppression). No benefit once symptoms start or after mpox infection.

Alternative intradermal regimen (EUA, age 18 and older)

0.1 mL intradermal, 2 doses 28 days apart

Dose-sparing option for shortages; supply is adequate, so subcut is preferred. Regimens are interchangeable; use subcut with HIV or immunocompromise.

Before vaccinating

Offer to GBMSM and transgender or nonbinary people with an STI, >1 partner, or sex at a commercial venue or large event in the past 6 months; their partners; anyone anticipating these; and clade I outbreak travelers anticipating sexual risk. Allow self-attestation. Contraindication: severe allergy to a prior dose or component.

Side effects and return precautions

Local reactions and fatigue, headache and myalgia are common; intradermal dosing causes more local reaction and lasting discoloration. Myocarditis/pericarditis is reported postmarketing; report cardiac events to VAERS.

Follow-up

Schedule dose 2 at 28 days; a late dose doesn’t restart the series. Boosters aren’t recommended for the general population. Prior mpox infection makes vaccination unnecessary.

Sources

Checked October 15, 2026.

Rabies vaccine (Imovax, RabAvert)Pre-exposure vaccination for travel

What to say

Rabies is almost always fatal once symptoms start, but it’s preventable. This vaccine is for travelers going where rabies is common and care may be hard to reach. You need 2 shots, 1 week apart: today and [date]. Finish both before you leave. If your risk will last more than 3 years, you’ll need a blood test or booster within that time.

Soreness, redness or swelling at the shot site, headache, nausea or muscle aches can happen. Call 911 for trouble breathing or face or throat swelling. The vaccine doesn’t replace care after a bite or scratch: wash the wound well with soap and water right away and get care promptly. Within 3 years of this series, you’d need only 2 more shots and no antibody injection.

Clinical reference

Dose schedules

Pre-exposure series (Imovax HDCV or RabAvert PCECV)

1 mL IM in the deltoid on days 0 and 7

Never in the gluteal area. Delays of a few days are inconsequential; don’t give dose 2 early.

Risk lasting more than 3 years (risk category 3)

One-time titer in years 1–3 (boost if <0.5 IU/mL), or 1 booster between day 21 and year 3

Travelers with ≤3 years of risk need no titer or booster. Immunocompromised: delay if possible; otherwise check titer ≥1 week (ideally 2–4 weeks) after the series.

Exposure after completed vaccination

Wound care plus 1 mL IM on days 0 and 3

No RIG. Exposure >3 years after a 2-dose series without titer or booster needs full PEP. Unvaccinated: RIG plus 4 doses (days 0, 3, 7, 14; add day 28 if immunocompromised).

  • ACIP 2022 replaced the 3-dose PrEP series with 2 doses. Immunocompetent travelers who had 3 doses, or an adequate titer 1–3 years after 2 doses, are considered primed for life.

Before vaccinating

Assess destination rabies risk, activities, trip length and access to RIG and PEP. Check severe allergy, immunocompromise and prior rabies vaccine. Consider avoiding chloroquine-class antimalarials during the series, or check titer afterward.

Side effects and return precautions

Local reactions and mild systemic symptoms are common. Hypersensitivity (hives, itching, malaise) follows about 6% of HDCV boosters, fewer with PCECV. Severe allergy is very rare.

Follow-up

Document both doses and the risk category; schedule a titer or booster for long-term risk; teach wound washing and prompt PEP after any bite or scratch abroad.

Sources

Checked October 15, 2026.

Japanese encephalitis vaccine (Ixiaro)Travel prevention

What to say

Japanese encephalitis is a rare but serious brain infection spread by mosquitoes in parts of Asia and the Western Pacific, mostly in rural farming areas. Your trip puts you at risk, so we recommend 2 shots: one today and one on [date, 7–28 days later]. Finish the series at least 1 week before you leave. If you keep traveling to risk areas, you may need a booster after a year or more.

Keep using insect repellent and covering up, since mosquitoes spread other infections too. Soreness, headache or muscle aches can follow the shot. Call 911 for trouble breathing, facial or throat swelling, or collapse. Contact us for severe or persistent symptoms, and tell us if you could be pregnant.

Clinical reference

Dose schedules

Adults 18–65

Two 0.5-mL IM doses 7–28 days apart; finish ≥1 week before travel

CDC Yellow Book schedule; the current US label lists the two doses 28 days apart.

Adults older than 65; booster

Two 0.5-mL IM doses 28 days apart; one booster ≥1 year after the primary series

Booster only if exposure continues or recurs, such as repeated travel to endemic areas.

Before vaccinating

Recommend for moves to, ≥1 month in, or frequent travel to endemic areas; consider shorter higher-risk rural or outdoor trips in season. Severe allergy to prior JE vaccine or protamine contraindicates; pregnancy is a precaution.

Side effects and return precautions

Injection-site pain, headache, myalgia, fever. Severe allergic reactions are very rare. Vaccination doesn’t replace mosquito-bite prevention.

Follow-up

Document both doses and booster eligibility. If the series can’t be finished ≥1 week before departure, reassess risk and reinforce bite precautions.

Sources

Checked October 15, 2026.

Yellow fever vaccine (YF-Vax)Travel prevention

What to say

Yellow fever is a serious virus spread by mosquitoes in parts of Africa and South America. Only designated centers give it, so we’ll refer you. One dose gives long-lasting protection for most people. Get it at least 10 days before arrival: your signed yellow card, the International Certificate of Vaccination, becomes valid 10 days after the shot, and some countries require it.

It’s a live vaccine. Tell us if illness or medicines weaken your immune system, you’ve had thymus problems, you’re pregnant or breastfeeding, or you have a severe egg allergy. Serious reactions are rare but more likely at 60 and older. Soreness, headache and mild fever are common. Call 911 for trouble breathing or facial swelling. Get urgent care for high fever, confusion, severe headache or yellow skin in the weeks after.

Clinical reference

Dose schedules

Primary vaccination

Single 0.5-mL subcutaneous dose at least 10 days before arrival

ICVP valid from 10 days after vaccination for life. Extra dose before next exposure: vaccinated while pregnant, or HSCT after vaccination; people with HIV every 10 years while at risk.

Booster consideration

One dose may be considered if ≥10 years since the last dose and travel is to higher-risk settings

Not needed for most travelers. Only YF-Vax is US-licensed; Stamaril was imported under expanded access during a past shortage.

Before vaccinating

Confirm itinerary risk or entry requirement. Contraindications: severe component/egg allergy, thymus disorder, symptomatic HIV or CD4 <200, primary immunodeficiency, immunosuppressive or immunomodulatory therapy, malignancy, transplant. Precautions: age ≥60, pregnancy, breastfeeding, CD4 200–499.

Side effects and return precautions

Mild local and systemic reactions are common. YEL-AND and YEL-AVD are rare but more frequent at ≥60 (YEL-AVD 1.2 per 100,000 doses at ≥60 vs 0.3 overall).

Follow-up

Confirm the ICVP is signed by the designated center and record the date. For contraindications, issue a medical waiver; destinations may not accept it.

Sources

Checked October 15, 2026.

Polio vaccine (IPOL)Adult booster for travel

What to say

Polio still spreads in some countries, including where you’re going. You had the polio series as a child, so one booster now tops up your protection; adults need only one in a lifetime. It contains no live virus. If you never finished the childhood series, you’ll need up to 3 doses, and we’ll fit in what we can before you leave. Some countries require long-stay visitors to show proof of a recent dose when leaving, so we’ll record it on your yellow card.

A sore, red or swollen arm can happen, and some people feel faint after shots. Tell us about any severe allergy to a vaccine or to the antibiotics neomycin, streptomycin or polymyxin B. Call 911 for trouble breathing, facial or throat swelling, or collapse. Contact us for severe or persistent symptoms.

Clinical reference

Dose schedules

Completed primary series (OPV or IPV)

One IPV 0.5-mL IM or subcutaneous booster before travel; single lifetime adult booster

For travel to countries with wild or vaccine-derived poliovirus circulation, or bordering areas with high contact risk.

Unvaccinated or incomplete series

Doses 1 and 2 4–8 weeks apart; dose 3 6–12 months after dose 2

Less time: >8 weeks, 3 doses ≥4 weeks apart; 4–8 weeks, 2 doses; <4 weeks, 1 dose. Finish later; don’t restart for delays.

Departure requirements

Where implemented, a dose 4 weeks–12 months before leaving an affected country after stays >4 weeks

Record on the ICVP; requirements change, so check CDC destination pages.

Before vaccinating

Review documented polio vaccination and current destination status. Contraindication: severe allergy to a prior dose or component (trace neomycin, streptomycin, polymyxin B). Pregnancy: give if immediate protection is needed.

Side effects and return precautions

Injection-site soreness, redness or swelling; syncope after injection. Severe allergic reactions are rare; inactivated IPV cannot cause polio.

Follow-up

Record the booster and any IHR-qualifying date on the ICVP. Complete remaining primary-series doses later if the schedule was shortened.

Sources

Checked October 15, 2026.

Tests and referrals

Complete blood count

What to say

I’m checking your blood count to see whether anemia, a low red blood cell count, could be contributing to how you feel. It also measures white blood cells and platelets. You don’t need to fast for this test alone.

This is one part of the evaluation, so a normal result won’t mean your symptoms are unimportant or that we have ruled out every cause. I’ll review it with the rest of your history and let you know what, if anything, we should do next. We’ll agree on when you should hear from us before you leave.

Clinical reference

  • Order CBC; add differential when the clinical question warrants it.
  • CBC alone generally needs no fasting. Explain any separate preparation for concurrently ordered tests.

Before ordering

State the clinical question and review prior counts/trends. Do not promise a CBC will establish or exclude all infections, nutritional deficiencies, or causes of fatigue.

Warning signs

Active major bleeding, chest symptoms, syncope or instability require assessment now, not a routine outpatient draw.

Follow-up

Name the result owner, expected local turnaround, and contact deadline. Persistent symptoms need a planned reassessment even if the CBC is normal.

Sources

Checked September 20, 2026.

Basic metabolic panel

What to say

This blood test checks how your kidneys are filtering and measures salts such as potassium and sodium. The medicine can change those levels even when you feel fine, so the blood test is part of starting it safely.

Please have it drawn on [date]. Follow the lab’s preparation instructions. Tell them which other tests we ordered. I’ll review the results and tell you whether the dose needs changing. Keep taking it as prescribed unless we advise otherwise. If you get very dizzy, pee much less than usual, or have vomiting or diarrhea that prevents drinking, call the same day instead of waiting for the blood test.

Clinical reference

  • Order BMP for electrolytes, glucose and renal indices; a CMP adds tests and is not automatically necessary.
  • For ACE/ARB initiation or dose increase in CKD, KDIGO recommends creatinine/potassium within 2–4 weeks; use earlier testing when risk warrants. Diuretic monitoring is individualized.

Before ordering

Check baseline creatinine/eGFR and electrolytes, volume status, interacting drugs, and the specific medicine. A small creatinine rise requires context rather than an automatic stop.

Warning signs

Severe weakness, palpitations, syncope or substantially reduced urine may need urgent assessment. Do not defer a concerning clinical presentation to scheduled monitoring.

Follow-up

Place the order with a due date and assigned reviewer. Arrange repeat testing or medication action for an abnormal result; communicate that decision.

Sources

Checked September 20, 2026.

Hemoglobin A1c

What to say

This test estimates your average blood sugar over about three months. You don’t need to fast for the A1c itself. It helps us see the overall pattern rather than just what your sugar is doing at one moment.

If we’re using it to make a new diagnosis and the result is high, we may need a second test to confirm it. If you already have diabetes, we’ll compare it with the goal we chose together and decide whether your treatment needs changing. A result outside the goal is information we can act on, not a grade.

Clinical reference

  • Order laboratory HbA1c for an appropriate diagnostic or monitoring question.
  • A1c ≥6.5% is in the diabetes range; confirm an asymptomatic new diagnosis with a second abnormal measurement. Consider factors that make A1c unreliable.

Before ordering

Anemia, altered red-cell turnover, some hemoglobin variants, pregnancy and other conditions can distort A1c. Use plasma-glucose criteria when indicated.

Warning signs

Polyuria/polydipsia with weight loss, vomiting, dehydration, or possible insulin deficiency needs timely glucose and clinical assessment; do not wait for a routine A1c.

Follow-up

Communicate the result and decision. Established diabetes often needs reassessment about three months after treatment changes; stable patients at goal may need less frequent testing.

Sources

Checked September 20, 2026.

Lipid panel

What to say

This measures cholesterol and triglycerides, another type of fat in the blood. We’ll use the results with your blood pressure, age, medical history and other risk factors to decide how much benefit a cholesterol medicine might offer.

Many cholesterol tests can be done without fasting, but I’ll tell you if your situation or the lab requires a fasting sample. A flagged number doesn’t by itself decide the treatment. We’ll review the result and agree on the next step, including whether lifestyle changes, medicine, or both fit your risk and preferences.

Clinical reference

  • Order lipid panel. A nonfasting sample is acceptable in many routine settings; select fasting testing when required to clarify triglycerides or the clinical question.
  • For primary prevention, use the current risk framework and relevant risk enhancers rather than a lone LDL value.

Before ordering

Known ASCVD, marked LDL elevation, diabetes, CKD, familial disorders and high triglycerides can change the pathway. Current 2026 ACC/AHA guidance incorporates PREVENT-ASCVD and LDL/non-HDL goals.

Warning signs

Unexpected severe hypertriglyceridemia requires prompt review; acute severe abdominal pain merits clinical assessment rather than a routine result message.

Follow-up

After starting or changing statin therapy, generally reassess lipids in 4–12 weeks; adjust the interval to the decision and adherence concerns.

Sources

Checked September 20, 2026.

TSH with reflex free T4

What to say

I’m checking the signal that tells your thyroid how much hormone to make. If that result is outside the expected range, the lab may also measure the thyroid hormone itself. That helps us assess whether a thyroid problem could be contributing to your symptoms.

Tell me about thyroid medicine, supplements and biotin, often found in hair-and-nail products, before the blood draw. Biotin can make some thyroid results misleading, so we’ll give you specific instructions if you take it. If we’ve just changed your thyroid dose, the timing matters: checking too early may not show the full response.

Clinical reference

  • TSH with reflex free T4 is a common initial order for suspected primary thyroid disease.
  • TSH alone is not sufficient when pituitary disease/central hypothyroidism is suspected. Specify pregnancy and medication context.

Before ordering

Review biotin dose, acute illness, amiodarone/lithium and thyroid medication timing/adherence. Do not infer that every fatigue or weight symptom is thyroid-related.

Warning signs

Severe tachycardia, chest pain, major mental-status change or systemic illness requires immediate clinical assessment.

Follow-up

For routine levothyroxine dose changes, check TSH about 6–8 weeks later. Pregnancy and central thyroid disease require a different monitoring plan.

Sources

Checked September 20, 2026.

TB blood test (IGRA)

What to say

This blood test shows whether your immune system has met TB germs. It needs a single blood draw and no return visit, and the BCG vaccine doesn’t affect it. A positive result usually means inactive, or latent, TB infection: the germs are asleep. That isn’t contagious, but it can become active later and make you sick.

We’ll send results by [date]. If it’s positive, we’ll check for symptoms and get a chest X-ray to rule out active TB, then discuss treatment to lower the chance it becomes active. If it’s unclear, we may repeat it. After recent contact with someone with TB, a negative test may need repeating 8–10 weeks later. Tell us about a cough lasting 3 weeks or more, coughing blood, fevers, night sweats or weight loss.

Clinical reference

  • Test adults at increased risk, with a plan to treat: born in or lived in high-TB countries, congregate settings (USPSTF B), recent contacts, immunosuppression. IGRA (QFT-Plus or T-SPOT.TB) is preferred after BCG or when a TST return visit is unlikely.
  • Positive: symptom review, exam and chest X-ray (sputum if indicated) to exclude TB disease before LTBI treatment. Indeterminate, borderline or invalid: repeat IGRA or do a TST. Don’t repeat after a documented positive or prior treatment.

Before ordering

Review symptoms, HIV and other immunosuppression (including planned biologics or transplant), contact history and prior positive tests. A negative IGRA doesn’t exclude TB disease; in low-risk people a positive result is less reliable.

Warning signs

Cough ≥3 weeks, hemoptysis, fever, night sweats or weight loss needs evaluation for TB disease (chest X-ray, sputum) regardless of the IGRA, with infection-control precautions.

Follow-up

Act on positives promptly: chest X-ray, then a short rifamycin-based LTBI regimen once disease is excluded. Retest contacts with an initial negative 8–10 weeks after last exposure. Give the patient a written copy of a positive result.

Sources

Checked October 15, 2026.

Comprehensive metabolic panel and liver tests

What to say

This blood test measures 14 things from one sample: kidney function, salts such as sodium and potassium, blood sugar, calcium, protein levels and liver tests. It shows how your kidneys and liver are working and whether a medicine might be affecting them. We’ll tell you if you need to fast first.

It’s common for 1 or 2 numbers to be slightly out of range. That often doesn’t mean anything is wrong, and sometimes we simply repeat the test. We’ll look at the whole pattern with your medicines and earlier results. You may see the numbers in your portal before we’ve reviewed them; [clinician or team] will explain them by [date]. If you notice yellow skin or eyes, very dark urine or severe belly pain, call [team] the same day.

Clinical reference

  • A CMP adds albumin, total protein, bilirubin, ALP, ALT and AST to the 8 BMP tests. Use a BMP when only renal function and electrolytes matter.
  • Specify fasting only when the lab or a paired test (fasting glucose, lipids) needs it. Repeat a mild isolated abnormality before an extensive work-up when the picture is reassuring.

Before ordering

Review hepatotoxic or nephrotoxic drugs, alcohol, supplements, dehydration, recent strenuous exercise or muscle injury (AST rise) and hemolysis (false high K and AST). Interpret calcium with albumin; check ionized calcium if unclear.

Warning signs

Act the same day on lab-called critical values (potassium, sodium, calcium, glucose), new jaundice, marked transaminase elevation with symptoms or an acute creatinine rise; don’t leave these to a routine portal note.

Follow-up

Communicate each result with a plan. Repeat abnormal values on a timeline matched to severity; follow persistent liver-test or calcium abnormalities through their own work-up.

Sources

Checked October 15, 2026.

Lipoprotein(a) test

What to say

Lipoprotein(a), or Lp(a), is a cholesterol-carrying particle. When it’s high, it raises your long-term chance of a heart attack or stroke. Your genes set your level, and it stays about the same through life, so most people need this test only once. Diet and exercise change it very little, so a high result isn’t something you did wrong.

Ask us whether you need to fast, since that depends on the lab and any other tests we draw. We’ll send results by [date]. If your level is high, we’ll treat the risks we can change more firmly, such as LDL cholesterol, blood pressure, blood sugar and smoking. Your close relatives may want testing too, because high levels run in families.

Clinical reference

  • 2026 ACC/AHA: measure Lp(a) at least once in every adult. High is 125 nmol/L (50 mg/dL) or more, about 1.4-fold ASCVD risk; 250 nmol/L (100 mg/dL) or more, at least 2-fold.
  • Request an apo(a) isoform-insensitive assay and note the units, which convert only approximately. One result is usually enough; levels shift with menopause, pregnancy, inflammation, and kidney, liver or thyroid disease.

Before ordering

Interpret with LDL-C, apoB, age, family history and other risk factors. Ask about premature ASCVD or high Lp(a) in relatives and about secondary causes: kidney, liver or thyroid disease, pregnancy, menopause, some medicines.

Warning signs

A high level raises long-term risk but doesn’t explain symptoms: chest pain, exertional breathlessness or stroke-like symptoms need their own evaluation. A normal LDL-C doesn’t exclude risk when Lp(a) is high.

Follow-up

Share the value and what it means for risk. If high, intensify control of LDL-C, blood pressure, glucose and tobacco use, consider earlier lipid-lowering treatment, and offer testing to first-degree relatives. Repeat testing is rarely needed.

Sources

Checked October 15, 2026.

B12, ferritin or vitamin D level

What to say

These blood tests check vitamin B12, which your nerves and blood cells need; ferritin, which shows your iron stores; and vitamin D, which supports your bones. We order them when there’s a reason, such as anemia, numbness or tingling, a bowel condition that affects absorption, or a bone problem. We don’t routinely check vitamin D in healthy adults without symptoms, because it’s unclear that testing helps.

Some labs ask you to fast for B12 or ferritin, so ask us first. Tell us about your medicines; metformin and acid reducers can affect B12 results. A low B12 usually needs a second test to confirm. A low ferritin means low iron stores, and we’ll look for the cause. A high ferritin doesn’t always mean extra iron. We’ll send results by [date].

Clinical reference

  • Order for a clinical question: anemia, neuropathy, malabsorption or GI surgery, restless legs, or bone disease. USPSTF finds insufficient evidence to screen asymptomatic adults for vitamin D deficiency.
  • B12 under 299 pg/mL (219 pmol/L) is possibly deficient; confirm with methylmalonic acid. Ferritin rises with inflammation, liver disease and obesity. Use total 25(OH)D; no single cutoff defines deficiency.

Before ordering

Review diet, metformin, PPI or H2-blocker use, GI surgery or malabsorption, blood loss and bone-health risks. Ask the lab about fasting and interfering medicines.

Warning signs

Low B12 with numbness, weakness or balance problems needs prompt treatment. Marked shortness of breath, fainting or an irregular heartbeat with anemia needs same-day assessment. Vitamin D toxicity is typically above 150 ng/mL.

Follow-up

Treat deficiency, look for the cause of low ferritin or B12, and recheck to confirm response. An abnormal level is a clue, not a diagnosis.

Sources

Checked October 15, 2026.

Celiac blood test

What to say

This blood test looks for antibodies your immune system makes when gluten, a protein in wheat, barley and rye, harms your small intestine. We usually check a tTG-IgA antibody and your total IgA, because low IgA can hide a positive result. Keep eating foods with gluten, like bread and pasta, for the weeks before the test. Don’t go gluten-free first, because that can hide celiac disease.

A negative result makes celiac disease unlikely. A positive result usually needs a camera test of the upper digestive tract, called an upper endoscopy, with small tissue samples to confirm it. If you’ve already cut out gluten, tell us so we can plan the next step with you. We’ll send results by [date].

Clinical reference

  • Test with tTG-IgA plus total IgA while the patient eats gluten; use an IgG-based test such as deamidated gliadin peptide (DGP) if IgA is low. Don’t start a gluten-free diet before testing.
  • Confirm positive serology with small-bowel biopsies at upper endoscopy. Negative HLA-DQ2/DQ8 makes celiac disease very unlikely; positive doesn’t confirm it. No routine screening, but relatives and people with type 1 diabetes can discuss testing.

Before ordering

Confirm current gluten intake and any prior gluten-free diet. Ask about weight loss, diarrhea, anemia, family history and type 1 diabetes. Check total IgA, or use IgG-based tests if IgA deficient.

Warning signs

If suspicion remains despite a negative test (ongoing diarrhea, weight loss, anemia), consider IgA deficiency or prior gluten avoidance before dismissing celiac disease.

Follow-up

Share the result and next step. Positive: arrange endoscopy with biopsies while the patient still eats gluten, and delay the gluten-free diet until the diagnosis is confirmed. Negative with low suspicion: no further celiac testing.

Sources

Checked October 15, 2026.

Morning testosterone test

What to say

This blood test measures your testosterone level. Levels are usually highest in the morning, so please come between 7 and 10 a.m. and, unless we tell you otherwise, don’t eat first. Tell us about all your medicines and supplements. Biotin can throw off hormone results and may need to be stopped at least 3 days before. Let us know if you’ve been sick recently, because we may wait until you’ve recovered.

One low result isn’t enough for a diagnosis, so if yours is low we’ll repeat it on another morning. We may also check free testosterone and the hormones LH and FSH to find the cause. A low number matters most when you also have symptoms. We’ll send results by [date] and talk about whether treatment makes sense.

Clinical reference

  • Endocrine Society 2018: diagnose hypogonadism only with symptoms plus consistently low testosterone. Start with a fasting morning total testosterone on a reliable assay and repeat it on a second morning.
  • Add free testosterone when total is near the lower limit of normal or SHBG may be abnormal. After confirming low testosterone, check LH and FSH. Defer testing during acute illness.

Before ordering

Confirm symptoms. Avoid testing during acute illness or on short-term testosterone-suppressing drugs such as opioids. Use an accurate assay and ask about biotin, which should stop at least 72 hours before sampling.

Warning signs

One low value doesn’t establish hypogonadism. Low testosterone with low or normal LH and FSH points to a pituitary or hypothalamic cause that needs evaluation.

Follow-up

Repeat a low result on a second morning. If confirmed, measure LH and FSH, look for causes, and decide about treatment with the patient. Review normal results against symptoms.

Sources

Checked October 15, 2026.

Urinalysis and urine culture

What to say

The first urine test looks for signs such as inflammation or blood. The culture checks whether bacteria grow and which antibiotics may work. They answer different questions, and the culture takes longer.

Please follow the clean-catch instructions and, if possible, give the sample before the first antibiotic dose. We won’t delay urgent treatment just to obtain a perfect sample. If we start an antibiotic now, I’ll review the culture and let you know whether to continue or change it. Fever, side or back pain, vomiting, or getting much sicker needs a same-day call.

Clinical reference

  • Select urinalysis and culture based on symptoms, recurrence, pregnancy, complicated features and resistance/treatment-failure concerns.
  • A reflex-culture rule is a lab workflow, not a diagnosis; verify the indication and collection method.

Before ordering

Bacteriuria or pyuria without compatible symptoms usually does not mean treat. Pregnancy and selected invasive endoscopic urologic procedures associated with mucosal trauma are important exceptions to asymptomatic-bacteriuria non-treatment.

Warning signs

Systemic illness, suspected infected obstruction or inability to hydrate needs an urgent pathway. Nitrofurantoin is not a pyelonephritis treatment.

Follow-up

Assign someone to review the final culture and susceptibility, including results arriving after an initial prescription. Reassess cystitis nonresponse within about 48 hours.

Sources

Checked September 20, 2026.

H. pylori stool or breath test

What to say

This looks for a stomach bacterium called H. pylori. If it’s present, treating the infection can be more useful than simply suppressing stomach acid. The stool or breath test checks for active infection.

The timing matters. Acid blockers such as omeprazole can hide the infection from the test. We’ll write down when to stop them and what you can use for symptoms in the meantime. Antibiotics and bismuth products such as Pepto-Bismol also affect testing. If we treat an infection, we’ll test again afterward to make sure it’s gone, even if you feel better.

Clinical reference

  • Use urea breath test or stool antigen for active infection as appropriate; serology is not a test of cure.
  • For test of cure: ≥4 weeks after antibiotics; hold PPI/PCAB for 2 weeks and antibiotics/bismuth for 4 weeks. Coordinate initial-test preparation with the laboratory and current guidance.

Before ordering

Check whether alarm symptoms, age/risk, bleeding, or another indication requires endoscopy rather than an uncomplicated test-and-treat pathway. Agree on a safe symptom bridge.

Warning signs

GI bleeding, severe pain, progressive dysphagia or persistent vomiting needs directed assessment; do not delay that workup for a routine stool test.

Follow-up

Give actual test and medication-hold dates. Assign result review, treatment if positive, and a test-of-cure order after treatment.

Sources

Checked September 20, 2026.

Urine albumin-to-creatinine ratio

What to say

This urine test looks for albumin, a protein that healthy kidneys keep in the blood. More than a trace in the urine can be an early sign of kidney damage from diabetes or high blood pressure. If we give you a cup for home, collect the first urine of the morning.

Hard exercise in the 24 hours before, a fever, a urine infection, very high blood sugar or your period can raise the result briefly, so tell us and we may test another day. One high result isn’t enough: 2 of 3 tests over 3–6 months need to be high. A confirmed high result guides medicines that protect your kidneys and heart. [Clinician or team] will send you the result by [date].

Clinical reference

  • Spot UACR with eGFR at least yearly in type 2 diabetes and type 1 diabetes ≥5 years (ADA 2026), at hypertension diagnosis, and 1–4 times yearly in CKD by stage. First morning sample preferred (KDIGO).
  • Categories: A1 <30, A2 30–299, A3 ≥300 mg/g. Label albuminuria only when 2 of 3 specimens over 3–6 months are abnormal.

Before ordering

Strenuous exercise within 24 h, infection, fever, heart failure, marked hyperglycemia, menstruation and marked hypertension can raise UACR; retest once resolved. Pair with eGFR; hematuria or an unexpected rise suggests another kidney cause.

Warning signs

Confirmed albuminuria raises the risk of kidney failure and cardiovascular events. Heavy or rapidly rising albuminuria, active urinary sediment or rapid eGFR decline needs prompt nephrology input.

Follow-up

Once confirmed, start or maximize ACE inhibitor or ARB, add an SGLT2 inhibitor when eligible (eGFR ≥20) and, in type 2 diabetes, consider finerenone (eGFR ≥25, normal potassium). Recheck UACR and eGFR by stage.

Sources

Checked October 15, 2026.

Urine drug test

What to say

With your OK, we’d like to check a urine sample for certain medicines and other substances. This test helps keep your treatment safe. It isn’t meant to punish you or end your care. Tell us about everything you take, including over-the-counter medicines and supplements, because some can change the result. Your results go in your medical record, which privacy laws protect.

The first test is a quick screen, and screens can be wrong. If a result doesn’t match what you told us, we’ll ask you about it before drawing conclusions, and we may send a more specific lab test. Some drugs, like fentanyl, need their own test. We’ll talk through the results without judgment and offer help if you want it. We’ll share results by [date].

Clinical reference

  • CDC 2022: consider toxicology testing before opioids and at least yearly during therapy, without bias and never to dismiss a patient from care. Explain the purpose and expected results beforehand.
  • Presumptive immunoassays can give false positives and negatives and miss synthetic opioids; fentanyl needs a specific assay. Confirm unexpected results with GC/MS or LC/MS when they affect management.

Before ordering

Document consent and indication. Know which drugs your panel detects. Reconcile prescribed medicines, over-the-counter drugs and supplements first, and review CURES, California’s prescription monitoring database, for controlled-substance prescriptions.

Warning signs

Don’t dismiss a patient from care or use words like “clean” or “dirty.” An unexpected result can reflect use, diversion, adverse effects or a false result; assess overdose risk and offer naloxone and treatment.

Follow-up

Discuss unexpected results with the patient first, then confirm with a specific assay if still unexplained. Use results to adjust care: pain plan, dose, monitoring frequency, naloxone, and treatment for opioid use disorder.

Sources

Checked October 15, 2026.

Pregnancy test

What to say

A pregnancy test looks for a hormone called hCG, which your body makes after a pregnancy begins. A urine test is quick and very accurate a week or two after a missed period. Testing too early can give a negative result even when you’re pregnant. First morning urine works best, so don’t drink large amounts of fluid beforehand. Sometimes we use a blood test instead.

If the test is negative and your period still hasn’t come, we’ll repeat it in about a week. If it’s positive, we’ll talk through all your options and next steps. If it’s positive and you have vaginal bleeding or pelvic pain, call us right away. Go to the emergency department or call 911 for sudden severe belly or shoulder pain, weakness, dizziness or fainting.

Clinical reference

  • Check pregnancy status before medicines or imaging that could affect a pregnancy. Positive: offer nondirective options counseling and early prenatal evaluation; exclude ectopic pregnancy if there is pain or bleeding.
  • False negative: testing too early or dilute urine; repeat in a week. False positive: fertility drugs, or rarely other hCG-raising conditions. Use quantitative blood hCG when ectopic pregnancy is possible.

Before ordering

Ask about last menstrual period, contraception, recent unprotected sex, fertility drugs and symptoms of ectopic pregnancy. Confirm pregnancy status before medicines or imaging with fetal risk.

Warning signs

A positive test with vaginal bleeding, pelvic or low back pain needs same-day assessment for ectopic pregnancy. Sudden severe abdominal or shoulder pain, weakness or fainting is an emergency.

Follow-up

Give the result with a clear plan. Negative with ongoing suspicion: repeat in about a week. Positive: options counseling or prenatal referral and a medication review. Pregnancy needs a different plan from this card.

Sources

Checked October 15, 2026.

FIT stool test

What to say

This is a home stool test that looks for small amounts of blood. It’s one way to screen for colon cancer when you don’t have symptoms. You collect the sample using the kit and return it by [date] using the instructions provided.

If it’s negative, we repeat it every year while this remains your screening plan. If it’s positive, the next step is a colonoscopy. Repeating the stool test wouldn’t settle the result. A positive test doesn’t necessarily mean cancer, but we need to find the source. Tell me now if you have bleeding or a change in bowel habits, because that can require a different evaluation.

Clinical reference

  • Order FIT, confirm kit delivery and return method. FIT generally needs no dietary restriction; follow the specific kit.
  • USPSTF recommends average-risk screening ages 45–75; ages 76–85 are individualized. Annual FIT is one option.

Before ordering

Distinguish screening from evaluation of anemia, rectal bleeding or other symptoms. Prior polyps, hereditary risk or family history may favor a different plan.

Warning signs

Do not use a negative screening result to dismiss ongoing symptoms. A positive FIT needs colonoscopy follow-through.

Follow-up

Track kit completion and results. Place and track colonoscopy referral after a positive result; use annual recall after a negative result when still eligible.

Sources

Checked September 20, 2026.

Colonoscopy

What to say

A colonoscopy lets the specialist examine the inside of the colon and remove many polyps, which are growths, during the same procedure. If a polyp or other tissue is sampled, the final laboratory result comes later than the procedure report.

The bowel preparation is important: if the preparation doesn’t clear enough stool, findings can be hidden and the test may need repeating. The endoscopy team will give you the exact diet and laxative schedule. We also need a plan for diabetes medicines, blood thinners and any weight-management injections. Don’t stop those on your own. Arrange the escort and transportation the sedation team requires. You shouldn’t drive yourself home after sedation. [Clinician or team] will contact you about any tissue results by [date]. Call [team] if you haven’t heard.

Clinical reference

  • State screening versus diagnostic indication, prior findings and due interval. Send relevant prior reports.
  • Endoscopy team chooses bowel preparation, medication adjustments, sedation plan and procedure-specific preparation.

Before ordering

Review anticoagulants/antiplatelets, diabetes drugs, GLP-1 therapy, kidney/heart disease, prior preparation problems and access/escort barriers. Discuss bleeding, perforation and sedation risks through the consent process.

Warning signs

Severe or increasing post-procedure abdominal pain, fever, substantial bleeding, fainting or persistent vomiting warrants urgent assessment according to discharge instructions.

Follow-up

Track scheduling, completion, pathology and the recommended surveillance interval. Do not close the loop with the visual procedure report if pathology is pending.

Sources

Checked September 20, 2026.

Screening mammogram

What to say

This is a screening picture of the breasts, intended to find changes before they cause symptoms. Each breast is compressed briefly to get a clear image. The center will tell you how to prepare and may ask for your previous images.

A call back for more pictures doesn’t automatically mean cancer. It means the screening image needs a closer look. If you have a new lump, nipple discharge or another breast change, tell me now, because we should order a diagnostic evaluation rather than treat this as routine screening. We’ll review the result and help arrange and follow up on any recommended next test.

Clinical reference

  • Order screening mammography when asymptomatic; use diagnostic breast evaluation for a new concerning symptom.
  • USPSTF recommends biennial screening ages 40–74 for the population covered by its recommendation. Higher-risk histories need a separate plan; recommendations differ across organizations.

Before ordering

Check prior imaging, breast symptoms, personal/genetic risk, implants and pregnancy possibility. Include the relevant history for radiology.

Warning signs

A new concerning symptom needs assessment even after a recent normal mammogram. Do not reassure solely on a screening result.

Follow-up

Track the final assessment and any additional imaging or biopsy recommendation. Confirm completion, not just placement of the next order.

Sources

Checked September 20, 2026.

Bone-density scan (DXA)

What to say

This scan measures bone density, usually at the hip and lower spine. It uses a small amount of X-ray radiation and helps us estimate fracture risk. It doesn’t tell us everything about bone strength or falls, so we’ll combine it with your medical history.

Follow the imaging center’s preparation instructions and tell them about recent scans with contrast dye or a possible pregnancy. Once we have the result, we’ll discuss whether exercise, nutrition, fall prevention and possibly medicine are appropriate. A low result is a starting point for a prevention plan, not a prediction that you’ll definitely break a bone.

Clinical reference

  • Order central DXA for an appropriate screening or diagnostic indication.
  • USPSTF: screen women ≥65 and younger postmenopausal women at increased fracture risk. Evidence is insufficient for a universal screening recommendation in men; clinical indications can still justify testing.
  • The imaging center may require no calcium supplements for at least 24 hours beforehand and a delay after recent contrast/barium studies; provide its exact instructions.

Before ordering

Prior fragility fracture, glucocorticoids, secondary causes and fall risk may require action beyond screening. Distinguish prevention from evaluation of a suspected acute fracture.

Warning signs

New severe focal pain after a fall needs fracture assessment; a routine DXA is not the test for an acute fracture.

Follow-up

Review the result with fracture risk and treatment options. Choose repeat timing based on baseline findings and treatment, not an automatic annual order.

Sources

Checked September 20, 2026.

Cervical cancer screening (Pap or HPV test)

What to say

This test looks for HPV, the virus behind almost all cervical cancers, and for cell changes that could turn into cancer. Depending on your age, we test for HPV, cells (a Pap test) or both. A clinician takes a quick swab during a speculum exam, or you may be able to swab your vagina yourself. For 2 days before, avoid sex, douching and vaginal creams or medicines.

We’ll send results by [date]. Normal results usually mean no test for 3–5 years. An abnormal result is common and usually isn’t cancer. It may mean a repeat test or a closer look at the cervix, called colposcopy. A positive self-swab needs a follow-up exam. Tell us about bleeding after sex, between periods or after menopause, because that needs its own exam.

Clinical reference

  • Average risk: cytology every 3 years at 21–29; at 30–65, primary hrHPV every 5 years (ACS-preferred), co-test every 5 or cytology every 3 (USPSTF 2018). ACS 2025 starts primary HPV at 25.
  • Self-collected hrHPV needs an FDA-approved kit (in clinic or at home) and suits asymptomatic, average-risk routine screening; ACS repeats a negative self-sample in 3 years. Specify the test and collection method.

Before ordering

Self-collection isn’t for HIV, DES exposure, ages 21–24, symptoms, or surveillance after abnormal results or treatment (ASCCP). Review prior results and hysterectomy type. Stop after 65 only after adequate negative screening (ACS: negative HPV or co-test at 60 and 65).

Warning signs

Postcoital, intermenstrual or postmenopausal bleeding, or a visible cervical lesion, needs diagnostic evaluation, not screening. A positive self-collected HPV result needs a clinician-collected speculum exam; track completion.

Follow-up

Manage abnormal results with ASCCP risk-based guidelines (repeat testing or colposcopy). Record test type and collection method to set the next interval. No screening after total hysterectomy for benign disease without CIN2+ history.

Sources

Checked October 15, 2026.

PSA test

What to say

This blood test can find prostate cancer early, but whether to test is your choice. From ages 55 to 69, screening prevents about 1 prostate cancer death per 1,000 men over 13 years. It also leads to false alarms, biopsies, and treatment of slow cancers that wouldn’t have caused harm, sometimes leaving bladder leaks or erection problems. Black men and those with a strong family history may start earlier.

Avoid ejaculation for 1–2 days before the blood draw. Tell us if you take finasteride or dutasteride, because they lower PSA. We’ll send results by [date]. A high PSA isn’t a diagnosis; infection or an enlarged prostate can raise it. We’ll usually repeat it, then discuss an MRI or a urologist if it stays high.

Clinical reference

  • USPSTF 2018: 55–69, individual decision after discussing benefits and harms (C); not at 70+ (D). AUA/SUO 2026: may offer baseline PSA at 45–50; offer from 40–45 with Black race, germline variants (e.g., BRCA2) or strong family history; every 2–4 years at 50–69.
  • Repeat a newly elevated PSA before MRI, biomarkers or biopsy; 25–40% normalize. 5-ARIs lower PSA after ≥6 months (doubling is only a rough adjustment). UTI, retention or recent instrumentation raise PSA; cycling and DRE don’t appreciably.

Before ordering

Document the shared decision and life expectancy. Review ancestry, family history and known germline variants, prior PSA values, urinary infection or retention, recent catheterization or cystoscopy, and 5-ARI use, including finasteride for hair loss.

Warning signs

Bone pain, weight loss or urinary retention with a high PSA needs prompt assessment; back pain with new leg weakness needs emergency care. Don’t give empiric antibiotics for an elevated PSA without infection symptoms.

Follow-up

Send results with a plan. Persistently elevated: risk calculator, prostate MRI and urology referral. Normal: rescreen in 2–4 years (longer if PSA <1 ng/mL) or document a decision to stop.

Sources

Checked October 15, 2026.

Lung cancer screening CT

What to say

This yearly low-dose CT scan looks for lung cancer early, when it’s more likely to be cured. It’s quick, needs no needles or dye, and uses a small dose of radiation. It helps most when done every year by people willing to have follow-up tests and treatment. If you still smoke, quitting matters most, and we can help today.

Small spots are common, and most aren’t cancer. Some need a repeat scan in a few months; a few need a PET scan or biopsy. The scan can also show other findings, like calcium in the heart arteries. We’ll send results by [date]. Coughing up blood, unexplained weight loss or a cough that won’t go away needs a visit now, not screening.

Clinical reference

  • Annual LDCT at 50–80 with ≥20 pack-years in people who smoke or quit within 15 years (USPSTF B); ACS sets no quit-time limit. Medicare: ages 50–77, with a documented shared decision-making visit (decision aid, cessation counseling) before the first scan.
  • Order screening LDCT with pack-years and quit date; results use a standardized system (Lung-RADS). USPSTF: stop 15 years after quitting, or when health limits life expectancy or ability or willingness to have curative surgery.

Before ordering

Confirm pack-years, quit date, absence of symptoms, prior chest CT, and fitness and willingness for curative surgery. Symptoms or a known nodule need diagnostic CT, not screening.

Warning signs

False positives and incidental findings (coronary calcium, emphysema, thyroid, adrenal or kidney lesions) are common; follow them by guideline, not reflexively. Hemoptysis, weight loss or persistent cough needs diagnostic evaluation.

Follow-up

Track the Lung-RADS category and its recommended step (annual, 6- or 3-month LDCT, PET/CT or tissue sampling) to completion. Offer tobacco treatment at every visit and recheck eligibility yearly.

Sources

Checked October 15, 2026.

HIV, hepatitis C and hepatitis B screening

What to say

We recommend these blood tests for most adults at least once, even without any known risk. HIV, hepatitis B and hepatitis C can stay silent for years while they harm the immune system or liver, and each has effective treatment. The hepatitis B test also shows whether you’re protected or should get the vaccine. You don’t need to fast.

We’ll send results by [date]. A positive screening test needs a second test to confirm it; we’ll call to explain and connect you with care. Very recent infections can be missed, so after a possible exposure we may repeat testing later. If a possible HIV exposure happened in the last 72 hours, tell us today, because medicine started quickly can help prevent infection.

Clinical reference

  • HIV: at least once at 15–65 (USPSTF A; CDC 13–64), younger or older with risk; at least yearly with ongoing risk. HCV: once for all adults (USPSTF 18–79), periodically with ongoing risk; antibody with reflex RNA.
  • HBV: once for all adults with the triple panel (HBsAg, anti-HBs, total anti-HBc; CDC 2023). Offer each routinely (opt-out): tell the patient testing is planned and that they may decline.

Before ordering

Ask about recent exposures: lab HIV Ag/Ab can miss 18–45 days and HCV antibody 8–11 weeks; use HIV NAT or HCV RNA when acute infection is possible. Check PrEP, injection drug use, HBV vaccine history and pregnancy (test each pregnancy).

Warning signs

Exposure within 72 hours needs same-day PEP assessment, not screening. Fever, rash, sore throat or swollen glands after exposure can be acute HIV; add NAT. Jaundice or dark urine needs prompt liver evaluation.

Follow-up

Give positive results directly, confirm them, and link to HIV or hepatitis care. Vaccinate HBV-susceptible adults; counsel resolved HBV infection about reactivation before immunosuppression. Rescreen yearly, or every 3–6 months for some, with ongoing risk.

Sources

Checked October 15, 2026.

STI testing

What to say

We’ll choose tests based on the kinds of sex you’ve had. For chlamydia and gonorrhea, you’ll give a urine sample or a vaginal swab you collect yourself; try not to pee for 1 hour before a urine sample. After oral or anal sex, we also test the throat or rectum, usually with a self-swab. A blood test checks for syphilis and HIV, and sometimes hepatitis.

We’ll send results by [date]. Some infections take a few weeks to show up, so after a recent exposure we may test again later. If a test is positive, we’ll arrange treatment, retest you in 3 months, and help your partners get treated; in California we can often prescribe for them directly. Tell us about sores, a rash, discharge, or pelvic or testicle pain.

Clinical reference

  • Test by exposure: CT/GC NAAT on a vaginal swab (self-collection is equivalent) or first-catch urine; rectal CT/GC and pharyngeal GC swabs by exposure; syphilis serology and HIV Ag/Ab; add hepatitis or trichomonas testing when indicated.
  • Screen sexually active women <25 yearly (older if at risk); MSM at least yearly at exposed sites, every 3–6 months if higher risk (PrEP, HIV, multiple partners). Retest 3 months after CT/GC treatment.

Before ordering

Take an anatomy-based sexual history. Ask about recent exposures (HIV Ag/Ab can miss 18–45 days; early syphilis serology can be negative), symptoms, pregnancy, PrEP or doxy-PEP use, and HPV, hepatitis A/B and mpox vaccination.

Warning signs

Ulcers, discharge, pelvic or testicular pain, or rash need diagnostic testing and often same-day treatment. Eye, ear or neurologic symptoms with possible syphilis, disseminated gonorrhea or acute HIV need urgent care.

Follow-up

Treat positives per CDC regimens and report as required. Offer partner treatment, including EPT for CT/GC when partners can’t be seen promptly (legal in California; shared decision for MSM). Pharyngeal GC needs a test of cure at 7–14 days.

Sources

Checked October 15, 2026.

Stool DNA or blood-based colon cancer test

What to say

These tests screen for colon cancer in people at average risk with no symptoms. For the stool DNA test, such as Cologuard, you collect a whole bowel movement at home with a mailed kit. No diet or medicine changes are needed. The blood test is a simple blood draw, but it misses more precancerous growths, so it’s a backup choice if you won’t do a stool test or colonoscopy.

A normal result means repeating it in 3 years. If it’s positive, you’ll need a colonoscopy to find the cause; repeating the test isn’t enough. Medicare covers these tests and that colonoscopy, but other plans vary. [Team] will send results by [date]. Tell us about bleeding, bowel changes or a family history of colon cancer, which need a different plan.

Clinical reference

  • Average risk, no symptoms, ages 45–75 (76–85 individualized). Stool: mt-sDNA (Cologuard, Cologuard Plus) or mt-sRNA (ColoSense) every 3 years per ACS 2026; USPSTF 2021 lists stool DNA-FIT every 1–3 years.
  • Blood (Shield; SimpleScreen CRC, approved 2026): ACS 2026 calls them non-preferred, only for patients who decline stool and visual tests. Medicare covers qualifying FDA-approved tests every 3 years at ages 45–85, plus follow-up colonoscopy as screening.

Before ordering

Confirm average risk: no personal history of adenomas, CRC or IBD; no family history of CRC, advanced adenoma or hereditary syndrome; no bleeding, iron deficiency or bowel change. Confirm willingness to have colonoscopy if positive.

Warning signs

A positive result needs colonoscopy, not repeat noninvasive testing. A negative screening result doesn’t rule out cancer in a patient with symptoms.

Follow-up

Track kit return or blood draw, the result and timely colonoscopy after a positive test. Set a 3-year recall after a negative result while still eligible.

Sources

Checked October 15, 2026.

Aortic aneurysm screening ultrasound

What to say

This one-time ultrasound measures your aorta, the main blood vessel in your belly. An aneurysm is a weak, bulging spot. It usually causes no symptoms, but a large one can burst, which is life-threatening. Screening is recommended for men aged 65–75 who have ever smoked. The scan takes about 10–15 minutes and doesn’t hurt. The imaging center will tell you whether to skip eating beforehand.

A normal result usually means no more scans. If your aorta is a bit wide, we’ll recheck it on a schedule. A larger aneurysm means seeing a vascular surgeon about repair. If you smoke, quitting helps keep an aneurysm from growing. [Team] will share results by [date]. Call 911 for sudden severe belly or back pain, or fainting.

Clinical reference

  • USPSTF 2019: one-time ultrasound for men 65–75 who ever smoked (≥100 cigarettes) (B); selectively offer to men 65–75 who never smoked (C); not for women who never smoked (D); insufficient evidence for women who smoked or have a family history (I).
  • Medicare covers once with a referral (family history of AAA, or men 65–75 with ≥100 cigarettes). SVS 2018 surveillance: 2.5–2.9 cm rescreen at 10 years; 3.0–3.9 cm every 3 years; 4.0–4.9 cm yearly; 5.0–5.4 cm every 6 months.

Before ordering

Confirm age, smoking history (≥100 cigarettes), family history of AAA and any prior aortic imaging. Abdominal or back pain or a tender pulsatile mass needs diagnostic imaging, not screening.

Warning signs

Sudden severe abdominal, flank or back pain, hypotension or syncope with known or possible AAA suggests rupture: call 911. A tender aneurysm needs emergency vascular evaluation.

Follow-up

Refer to vascular surgery at ≥5.5 cm in men (SVS suggests repair at 5.0–5.4 cm in women), rapid growth or symptoms. Advise smoking cessation, which SVS recommends to reduce growth and rupture.

Sources

Checked October 15, 2026.

Electrocardiogram (ECG)

What to say

An ECG records your heart’s electrical signals. It shows how fast your heart beats, whether the rhythm is steady, and clues to past heart damage. It takes a few minutes and doesn’t hurt: small stickers on your chest, arms and legs pick up the signals, and no electricity goes into your body. Avoid exercise or cold drinks right before it.

A normal ECG is reassuring but doesn’t rule out every heart problem, especially one that comes and goes, so we may suggest other tests. If something looks different, we’ll compare it with earlier ECGs and explain the next step. [Clinician or team] will go over the result by [date]. For chest pain or pressure, severe shortness of breath or fainting, call 911 instead of coming in for an ECG.

Clinical reference

  • Use for palpitations, syncope, stable chest pain or dyspnea, suspected structural or conduction disease, and QT or rate monitoring with relevant drugs. Preoperative ECG only when patient and surgical risk warrant it.
  • Not for screening asymptomatic low-risk adults (USPSTF D; I statement for intermediate or high risk). Possible acute coronary syndrome needs emergency care, not an office ECG.

Before ordering

Clarify the question (rhythm, ischemia, QTc, conduction, chamber enlargement). Review QT-prolonging drugs, potassium and magnesium, and prior tracings. Intermittent symptoms usually need ambulatory monitoring.

Warning signs

Acute ischemic changes, new high-grade AV block, sustained VT, QTc over 500 ms or a symptomatic arrhythmia need same-day or emergency action.

Follow-up

Document the interpretation and compare with prior ECGs. Arrange a monitor, echo or cardiology referral when findings or symptoms warrant; repeat after QT-drug changes as planned.

Sources

Checked October 15, 2026.

Echocardiogram

What to say

An echocardiogram is an ultrasound of your heart. It shows how well your heart pumps, the size of its chambers and how the valves open and close. It uses sound waves, not radiation, and usually needs no preparation. A technician moves a gel-covered probe over your chest while you lie on your side. It usually takes under an hour. Sometimes contrast through an IV makes the pictures clearer.

A heart specialist reads the images. The report describes your pumping strength, called the ejection fraction, and any valve problems. Small findings, such as a mildly leaky valve, are common and often need no treatment. [Clinician or team] will explain the result by [date]. If you have chest pain, severe shortness of breath or fainting before then, call 911.

Clinical reference

  • Order transthoracic echo (TTE) for suspected heart failure, a murmur suggesting structural disease, unexplained dyspnea or edema, or syncope with suspected structural disease. State the question and key findings (murmur, BNP, ECG).
  • TEE and stress echo are separate orders. Repeat only for a change in clinical status or at a planned surveillance interval for known valve or ventricular disease.

Before ordering

Check for prior echo reports and dates. Note AF or other rhythm issues, body habitus or lung disease that may limit image quality, and any prior reaction to ultrasound contrast.

Warning signs

Severely reduced EF, severe valve stenosis, a large pericardial effusion or intracardiac thrombus need prompt review and timely cardiology input; symptoms with these findings need urgent assessment.

Follow-up

Communicate EF and key valve findings with the plan. Start guideline-directed therapy or refer as indicated; schedule surveillance echo per valve or cardiomyopathy guidance.

Sources

Checked October 15, 2026.

Stress test

What to say

A stress test checks your heart during exercise. You’ll walk on a treadmill, or get an IV medicine if you can’t exercise, while we watch your heart tracing and blood pressure. Some tests add heart pictures and take longer. Wear comfortable shoes. Don’t eat or smoke for 3 hours beforehand, and usually avoid coffee, tea, soda and chocolate for 24 hours. Ask which medicines to take that day, and tell us about any erection medicine taken in the past 2 days.

A normal result is reassuring but doesn’t rule out every heart problem. An abnormal result may mean a narrowed artery and lead to more tests. [Clinician or team] will contact you by [date]. For chest pain or pressure at rest, or worsening pain before the test, call 911.

Clinical reference

  • For stable exertional symptoms: exercise ECG if the patient can exercise and the resting ECG is interpretable; otherwise stress echo or nuclear imaging, pharmacologic if unable to exercise. State which drugs to hold.
  • Not for screening asymptomatic low-risk adults (USPSTF D). Rest, prolonged or accelerating chest pain needs emergency evaluation, not an outpatient stress test.

Before ordering

Exclude acute coronary syndrome, decompensated heart failure, symptomatic severe aortic stenosis and uncontrolled arrhythmia first. Clarify holding beta-blockers or nitrates and recent PDE-5 inhibitor use; bronchospasm limits some pharmacologic agents.

Warning signs

Rest pain, syncope or escalating symptoms while awaiting testing need same-day or emergency evaluation. High-risk results, such as marked ischemia or a fall in blood pressure with exercise, need prompt cardiology input.

Follow-up

Communicate the result and plan. Abnormal or nondiagnostic tests usually lead to cardiology review for further imaging or angiography; continue risk-factor treatment whatever the result.

Sources

Checked October 15, 2026.

Wearable heart monitor

What to say

This monitor records your heart rhythm while you go about normal life. Depending on how often your symptoms happen, it may be a Holter monitor for 1–2 days, a patch for up to 14 days or an event monitor for up to 30 days. Log each symptom and what you were doing, and press the button if your device has one. Some devices must stay dry and others allow a quick shower, so follow the instructions you’re given.

When you’re done, return or mail the device as instructed. The recording is analyzed, and [clinician or team] will contact you by [date]. Many monitors aren’t watched in real time. If you faint, have chest pain or feel very short of breath, call 911 rather than relying on the monitor.

Clinical reference

  • Match duration to symptom frequency: daily symptoms, 24–48 h Holter; weekly to monthly, 14-day patch or 30-day event monitor; rare events, consider an implantable loop recorder.
  • Specify the indication (palpitations, syncope, AF detection or rate control, cryptogenic stroke) and duration. Confirm whether the device transmits in real time and who receives urgent alerts.

Before ordering

Get an office ECG first. Ask about symptom frequency, adhesive allergy or skin problems, and ability to return the device. Review rate-slowing drugs that could explain findings.

Warning signs

Syncope that is exertional, comes with chest pain or palpitations, or occurs with a family history of sudden death or known structural heart disease needs urgent evaluation, not outpatient monitoring alone.

Follow-up

Track device return and the report. Correlate the diary with findings; act on AF (stroke-risk assessment), significant pauses or VT, and extend monitoring if symptoms weren’t captured.

Sources

Checked October 15, 2026.

Coronary artery calcium scan

What to say

This quick, low-radiation CT scan, done without dye, measures hardened plaque, called calcium, in your heart arteries. We use it when your risk is in a middle range and the result would change whether you start a cholesterol medicine. Many centers ask you to avoid caffeine and smoking for 4 hours beforehand. Insurance may not cover it; ask about the self-pay price.

A score of 0 means very low near-term risk, so you may be able to skip medicine for now and rescan in a few years. Any calcium usually means a statin would help. It can also show something unrelated, such as a lung spot, needing follow-up. [Clinician or team] will review it with you by [date]. It isn’t for chest pain; for chest pain or pressure, call 911.

Clinical reference

  • Men ≥40 and women ≥45 without ASCVD at intermediate (PREVENT 5% to <10%) or selected borderline (3% to <5%) 10-year risk when the statin decision is uncertain (2026 ACC/AHA).
  • Noncontrast gated CT, about 1 mSv. Coverage varies; out-of-pocket cost is about $50–250. Not for symptomatic patients, and don’t repeat once on lipid-lowering therapy.

Before ordering

Estimate PREVENT risk first. Skip CAC with known ASCVD, FH or LDL-C >190 mg/dL. A score of 0 shouldn’t defer statins with diabetes over 40, current smoking or a strong family history of premature ASCVD.

Warning signs

CAC ≥300, and especially ≥1000, carries risk similar to established ASCVD; intensify LDL lowering, adding nonstatins if needed. Incidental findings such as lung nodules (<10%) need tracked follow-up.

Follow-up

CAC 1–99: moderate-intensity statin, LDL-C <100 mg/dL. CAC ≥100 or ≥75th percentile: ≥50% reduction, LDL-C <70 (<55 if ≥1000). CAC 0 without high-risk features: may defer and repeat in 3–7 years.

Sources

Checked October 15, 2026.

Chest X-ray

What to say

Your symptoms and examination give me a reason to check for a lung problem such as pneumonia. The X-ray is quick and usually needs no special preparation. Tell the technologist if you could be pregnant.

The picture will help with our next decision, but a normal X-ray doesn’t rule out every cause of chest symptoms or breathlessness. We’ll agree whether you need it today and how I’ll get the result to you. For severe breathing difficulty, severe chest pain or fainting, call 911. Don’t wait for the image or my message.

Clinical reference

  • For a stable ambulatory patient, PA/lateral chest radiographs are a common diagnostic order; select the protocol to the question.
  • State the indication and required timing. No routine chest X-ray for an uncomplicated cough without pneumonia concern.

Before ordering

Assess vitals, oxygenation, respiratory effort and risk. Radiography must not delay emergency evaluation of possible ACS, pulmonary embolism or respiratory failure.

Warning signs

Severe breathlessness, hypoxemia, instability or concerning chest pain needs a higher-acuity pathway; a normal film cannot clear these presentations.

Follow-up

Assign same-day review when ordered for an acute same-day decision. Set a follow-up plan if symptoms persist despite an unrevealing image.

Sources

Checked September 20, 2026.

Sleep study

What to say

The snoring, breathing pauses and daytime sleepiness make me concerned that your airway may be closing during sleep. The test measures breathing and oxygen levels while you sleep. We’ll choose a home test or a sleep-lab study based on your health and the question we need to answer.

A home test is convenient, but it can miss sleep apnea. If it’s negative, inconclusive or technically incomplete, we’ll arrange an in-lab study to assess this properly. Please follow the sleep center’s instructions and contact us if you have trouble arranging the test. If you’re sleepy enough to nod off driving, don’t drive until we have addressed that risk.

Clinical reference

  • Home sleep apnea testing can fit uncomplicated adults at increased risk of moderate–severe OSA after clinical evaluation.
  • Use polysomnography when indicated by significant comorbidity, other suspected sleep disorders, or a negative/inconclusive/technically inadequate home test.

Before ordering

Assess driving/occupational sleepiness, cardiopulmonary disease, hypoventilation risk, opioids, neuromuscular disease, stroke and severe insomnia. A questionnaire alone does not diagnose OSA.

Warning signs

Drowsy driving requires immediate safety advice. Do not close the evaluation simply because an inadequate or negative home study is returned.

Follow-up

Track scheduling and the interpreted report; arrange result discussion and treatment. Provide an explicit next step after a nondiagnostic study.

Sources

Checked September 20, 2026.

Spirometry

What to say

This breathing test measures how much air you can blow out and how quickly. You’ll take a deep breath and blow hard into a mouthpiece, usually several times. The technician may repeat it after an inhaler to see how the airflow changes.

The testing team will tell you whether to skip any inhaler doses beforehand. Don’t stop them without those instructions. Tell them about any current illness, recent procedure or medical problem so they can check whether the test is safe today. The result helps us choose treatment, but we’ll interpret it with your symptoms, not as a stand-alone answer.

Clinical reference

  • Order spirometry, with bronchodilator testing when it addresses the diagnostic question.
  • Ask the lab to provide medication-hold and preparation instructions; technique and acceptability affect interpretation.

Before ordering

Check clinical stability and testing contraindications. Asthma may require repeat or other testing when baseline spirometry is normal; COPD diagnosis requires appropriate post-bronchodilator evidence and context.

Warning signs

An acute severe breathing problem needs treatment and triage, not waiting for elective pulmonary-function testing.

Follow-up

Review quality and interpretation, then explain whether the result supports the suspected condition and how it changes the inhaler plan.

Sources

Checked September 20, 2026.

Physical therapy referral

What to say

I’m referring you to physical therapy to help improve movement and strength for the activities that are difficult. The aim isn’t just to reduce today’s pain. It’s to make walking, working or the task you chose easier.

The therapist will assess you and give you a home plan, which is an important part of treatment between visits. Some exercise soreness can happen, but new or worsening leg weakness, numbness in the groin, or trouble controlling or emptying the bladder or bowel means go to the emergency department. If cost, scheduling or travel makes therapy difficult, tell us so we can adapt the plan rather than leave you without one.

Clinical reference

  • State the diagnosis, functional limitation, precautions and goal in the referral.
  • For uncomplicated low back pain, exercise-based care is appropriate; imaging is not routinely required before referral.

Before ordering

Exclude red flags and identify fall risk, postoperative restrictions or neurologic deficits. Choose a goal the patient can measure, such as walking duration.

Warning signs

New bladder/bowel dysfunction, saddle sensory change or progressive weakness needs emergency assessment rather than a routine PT appointment.

Follow-up

Confirm the patient can access therapy and reassess function after an initial course, often around 4–6 weeks in a stable case; sooner for deterioration.

Sources

Checked September 20, 2026.

Ultrasound

What to say

An ultrasound uses sound waves, not radiation, to make pictures inside your body. A technologist moves a small probe over gel on your skin. It doesn’t hurt, though you may feel pressure. For a gallbladder or liver scan, you’ll likely need to skip food for several hours. A pelvic scan may need a full bladder; for some, a slim vaginal probe gives a clearer view. The center will give exact instructions.

A radiologist, a doctor who reads scans, sends us a report. Ultrasound sometimes finds small, harmless things unrelated to the reason for the scan, and some need a follow-up scan. [Clinician or team] will explain the results by [date]. For severe belly pain, fever with belly pain or yellow skin or eyes, get same-day care instead of waiting.

Clinical reference

  • Name the body part and question: RUQ for gallstones, thyroid for nodule characterization, pelvic transabdominal with or without transvaginal, or a soft-tissue mass. Add Doppler when blood flow matters.
  • Ultrasound is usually the first test for these areas. Confirm the preparation (fasting for RUQ, full bladder for transabdominal pelvic) and whether a transvaginal study is acceptable to the patient.

Before ordering

Offer a chaperone and explain the transvaginal option in advance. Choose CT or MRI when ultrasound can’t answer the question (body habitus, bowel gas, deep structures).

Warning signs

Severe abdominal pain with fever, jaundice or peritoneal signs, or suspected ovarian or testicular torsion or ectopic pregnancy, needs emergency assessment rather than an outpatient scan.

Follow-up

Review the report for the answer and any incidental findings. Place and track the follow-up imaging or referral the radiologist recommends, and tell the patient the plan.

Sources

Checked October 15, 2026.

CT scan

What to say

A CT scan uses X-rays and a computer to make detailed pictures. You lie on a table that slides through a large ring; scanning takes minutes. Some scans need contrast dye, by IV or as a drink, and you may need to skip food for a few hours first. IV dye can cause a brief warm feeling and a metallic taste. Tell us about possible pregnancy, kidney disease, metformin use or past contrast reactions.

CT uses more radiation than a regular X-ray, so we order it when the result will change your care. Small unrelated findings are common; some need a follow-up scan. Insurance may need to approve it. [Clinician or team] will explain the report by [date]. If you get hives, swelling or trouble breathing after contrast, call 911.

Clinical reference

  • Specify body region, clinical question and contrast (none, IV, oral), or ask radiology to choose the protocol for questions such as stone, nodule or pulmonary embolism. Many plans require prior authorization.
  • Check for recent comparable imaging before ordering. With IV iodinated contrast, review eGFR when CKD or risk factors are present, prior contrast reactions and pregnancy status.

Before ordering

Metformin per ACR/KDIGO: hold only with AKI or eGFR ≤30, then restart after ≥48 h if renal function is stable. The FDA label is stricter (eGFR 30–60, liver disease, alcohol use, heart failure, intra-arterial contrast).

Warning signs

Immediate contrast reactions (hives, wheeze, hypotension) need emergency care; delayed rashes can appear within days. With eGFR <30 or AKI, avoid dehydration and recheck kidney function. Act on critical findings the same day.

Follow-up

Track the report and recommended follow-up (for example, Fleischner intervals for nodules). Tell the patient the result and plan, and record who owns the follow-up.

Sources

Checked October 15, 2026.

MRI

What to say

An MRI uses a strong magnet and radio waves, not X-rays, to make detailed pictures. You lie still in a narrow tube for 30–60 minutes while it makes loud thumping sounds; you’ll get earplugs. If tight spaces bother you, tell us; an open scanner may help, or a calming medicine if someone can drive you home. Some scans use a contrast dye called gadolinium.

Because of the magnet, tell us and the MRI team about any pacemaker, defibrillator, brain aneurysm clip, cochlear implant, medicine pump or metal fragments, including past sheet-metal work. Many newer devices are safe with special steps. Insurance may need to approve the scan first. MRIs often show age-related changes that may not explain your symptoms. [Clinician or team] will explain the report by [date].

Clinical reference

  • Specify region, question and contrast need, or ask radiology to protocol. Not for uncomplicated low back pain without red flags; many plans require prior authorization.
  • Complete MRI safety screening: make and model of pacemakers, ICDs and neurostimulators (MR-conditional protocols), aneurysm clips, pumps, cochlear implants and metal fragments (orbit X-ray for metalworkers).

Before ordering

Gadolinium: check eGFR with CKD, AKI or dialysis; with eGFR <30, radiology uses group II agents. Plan anxiolysis with a driver for claustrophobia, and confirm the patient can lie still and flat.

Warning signs

Cauda equina symptoms, progressive neurologic deficit or suspected infection, fracture or cancer need an urgent pathway, not routine outpatient MRI scheduling.

Follow-up

Review the report against the clinical question, explain common age-related findings, and track recommended follow-up or referral when results change management.

Sources

Checked October 15, 2026.

Leg vein ultrasound

What to say

This ultrasound looks at the veins in your leg. It checks for a blood clot and can also show whether the valves inside the veins leak, which can cause varicose veins. You usually don’t need to prepare. The technologist spreads gel on your skin and presses a small probe along the veins. It shouldn’t hurt, though pressing on a sore leg can be uncomfortable.

If we’re looking for a clot, we try to scan the same day. If there’s a delay, we may start a blood thinner until it’s done. A radiologist reads the images, and [team] will give you the result by [date]. Call 911 for chest pain, sudden shortness of breath or coughing up blood. Get same-day care if the leg becomes much more swollen or painful.

Clinical reference

  • Suspected DVT: use the two-level Wells score. If DVT likely, get a proximal leg vein ultrasound within 4 hours; if that isn’t possible, check D-dimer, start interim therapeutic anticoagulation and scan within 24 hours (NICE NG158).
  • DVT likely with a negative proximal scan and positive D-dimer: repeat the scan in 6–8 days. For varicose veins or chronic venous insufficiency, order a venous reflux (insufficiency) study, not a DVT study, and state the side.

Before ordering

If DVT is unlikely by Wells, check D-dimer first and scan only if positive. Before interim anticoagulation, check bleeding risk, renal function, platelets, pregnancy and interacting drugs. Ask about PE symptoms.

Warning signs

Chest pain, dyspnea, hemoptysis, tachycardia or syncope suggests PE: emergency. Massive swelling with cyanosis or pallor (phlegmasia) needs emergency care. Watch for bleeding on interim anticoagulation.

Follow-up

Act on suspected-DVT results the same day: continue or stop anticoagulation. Book the 6–8 day repeat scan when indicated. Send reflux study results to the vein specialist if treatment is planned.

Sources

Checked October 15, 2026.

Diagnostic mammogram and breast ultrasound

What to say

Because of [your breast symptom or the screening callback], I’m ordering a diagnostic exam, which is more detailed than routine screening. It may include extra mammogram pictures from more angles and an ultrasound, which uses gel and sound waves. If you’re under 30, it usually starts with ultrasound. Tell the center where you’ve had breast imaging. You may hear results before you leave.

Most findings aren’t cancer. Some need a repeat check in 6 months. A suspicious area needs a biopsy, which takes a small tissue sample. If the pictures look normal but you still feel the lump, tell us, because it may still need a specialist’s exam. Diagnostic imaging can cost more than screening, so check your plan. [Team] will go over results and next steps by [date].

Clinical reference

  • Use for a lump, persistent focal pain, spontaneous or bloody nipple discharge, skin or nipple change, or a BI-RADS 0 screening callback. ACR 2022 (palpable mass): ≥40, diagnostic mammogram or DBT, then targeted ultrasound as needed; 30–39, ultrasound, mammogram or DBT; <30, ultrasound first.
  • Specify side, location (clock face, distance from nipple), duration and prior imaging. BI-RADS 3: 6-month follow-up; 4–5: biopsy. Probably benign imaging doesn’t preclude biopsy when clinical suspicion persists.

Before ordering

Examine and document the finding. Ask where prior imaging was done, and about implants, pregnancy or breastfeeding, and personal or family risk.

Warning signs

Fever with a red, hot, tender breast suggests mastitis or abscess; rapidly spreading redness or skin thickening raises concern for inflammatory cancer. Both need prompt assessment.

Follow-up

Track the final BI-RADS category and completion of biopsy or 6-month imaging. Re-examine palpable findings with benign imaging; refer to breast surgery if one persists or looks suspicious.

Sources

Checked October 15, 2026.

Specialist referral

What to say

I’m referring you to [specialty] to answer a specific question: [question]. I’ve marked it as [routine or urgent]. [Team or the specialist’s office] will call you to schedule. Some plans need a referral or approval before the visit, and we’ll send that request. If you haven’t heard by [date], call [team and phone number] so we can follow up.

We’ll send your records. Bring a list of your medicines, your questions and any outside test results. After the visit, the specialist sends us their notes, and we’ll go over the plan together so your care stays coordinated. If your symptoms get worse while you wait, don’t wait for the appointment. Call us, or go to the emergency department or call 911 if it’s severe.

Clinical reference

  • State the clinical question, urgency, pertinent history, results and treatments tried; attach records and imaging. Say whether you want advice (consultation) or for the specialist to take over care.
  • Check network and prior authorization rules; HMO plans often require a referral before specialist care. Consider an e-consult when the question may not need a visit.

Before ordering

Confirm in-network options, authorization needs, interpreter or accessibility needs, transportation, and the patient’s preferences and goals.

Warning signs

Worsening symptoms during the wait should prompt reassessment and escalation; a pending referral shouldn’t delay urgent or emergency care.

Follow-up

Track scheduling, completion and the consult note. Reconcile recommendations and medications, and tell the patient who manages what next.

Sources

Checked October 15, 2026.

Therapy referral

What to say

Talk therapy helps many people, alone or with medicine. Common types include cognitive behavioral therapy, or CBT, which teaches practical skills; trauma-focused therapy; couples therapy; and CBT for insomnia. To find a therapist, call the mental health number on your insurance card or use your plan’s directory, and ask about video visits and cost. We can also connect you with [behavioral health team], if available.

The first visit is mostly about your history and goals. It can take a few sessions to know if it’s a good fit, and it’s fine to switch. If you have thoughts of harming yourself, call or text 988 any time, or call 911. We’ll check in with you by [date] to see how it’s going and whether you were able to start.

Clinical reference

  • Match therapy to the problem: CBT or behavioral activation for depression; CBT for anxiety disorders; trauma-focused therapy (CPT, PE, EMDR) for PTSD; CBT-I for chronic insomnia; couples therapy for relationship distress.
  • Include diagnosis, safety assessment, baseline PHQ-9 or GAD-7 and goals. Collaborative care, if available, adds care management and psychiatric consultation in primary care.

Before ordering

Assess suicide risk, substance use, psychosis, mania and safety at home; these may need urgent psychiatric or crisis care, not a routine referral. Note language, cultural and cost barriers.

Warning signs

Suicidal intent or plan, inability to care for self, psychosis or rapid worsening needs same-day crisis assessment or emergency care, not a waitlist.

Follow-up

Check in within 2–4 weeks on access and engagement. Repeat PHQ-9 or GAD-7 and adjust treatment if symptoms aren’t improving.

Sources

Checked October 15, 2026.

Diabetic eye exam

What to say

Diabetes can damage blood vessels in the retina, the back of the eye. Early damage usually causes no symptoms, and treatment can protect your vision. An eye doctor can check with drops that widen your pupils. Another option is special photos of the retina, read by a specialist or an approved computer program. If the photos show changes or aren’t clear, you’ll need a full eye exam.

Dilating drops can blur your vision and make you light-sensitive for a few hours, so bring sunglasses and someone to drive you. Most people need this exam yearly. If you’ve had normal exams and your diabetes is well controlled, every 1–2 years may be enough. We’ll share results by [date]. Get urgent care for sudden vision loss or new floaters or flashes.

Clinical reference

  • ADA 2026: type 2 at diagnosis, type 1 within 5 years of onset. Then yearly; every 1–2 years if no retinopathy on ≥1 annual exam and glycemia at goal; at least yearly with any retinopathy.
  • Retinal photography with remote reading or FDA-approved AI is acceptable if positive or ungradable images route to an eye exam. Photos don’t replace a comprehensive eye exam.

Before ordering

Confirm the date and result of the last exam. Pregnancy or planned pregnancy needs earlier and closer eye follow-up. Consider closer follow-up with existing retinopathy when glucose is lowered rapidly.

Warning signs

Sudden vision loss, a curtain over vision, or a shower of floaters or flashes needs same-day ophthalmology. New blurred or distorted vision needs prompt eye referral.

Follow-up

Obtain and file the report and set the recall interval. Refer abnormal or ungradable photos for a dilated exam. Optimize glucose, blood pressure and lipids.

Sources

Checked October 15, 2026.

Upper endoscopy

What to say

An upper endoscopy uses a thin tube with a camera to look at your esophagus, stomach and the first part of your small intestine. You’ll usually get sedation, and it takes 10–20 minutes. If the doctor takes tiny tissue samples (biopsies), results can take days or longer; [clinician or team] will share them by [date].

You’ll usually skip food and drink for up to 8 hours, as the team directs. Don’t stop diabetes medicines, blood thinners or weight-loss injections on your own; we’ll make a plan. You’ll need a ride home. A mild sore throat is common, but call [team] right away for fever or a worsening one. Go to the emergency department or call 911 for trouble breathing, severe chest or belly pain, vomiting blood, or black stools.

Clinical reference

  • State the indication (swallowing trouble, persistent heartburn, pain or vomiting, suspected bleeding, Barrett or celiac evaluation) and send prior endoscopy and pathology reports.
  • The endoscopy unit sets fasting, sedation and medication holds, including anticoagulants, diabetes drugs and GLP-1 therapy. Biopsies are common; sedation reactions, bleeding and perforation are uncommon.

Before ordering

Review anticoagulants and antiplatelets, diabetes drugs including GLP-1 therapy, sleep apnea and heart or lung disease that affect sedation, prior endoscopy or pathology, and transportation. Consent covers bleeding, perforation and sedation risks.

Warning signs

After the procedure, trouble breathing, worsening throat pain or swallowing, vomiting (especially bloody or coffee-ground), worsening chest or abdominal pain, black or bloody stool, or fever needs urgent assessment.

Follow-up

Track scheduling, completion and pathology; biopsy results can take days or longer. Share results with a plan, including treatment and any surveillance interval. Don’t close the loop on the visual report while pathology is pending.

Sources

Checked October 15, 2026.

Nerve conduction study and EMG

What to say

These tests check how well your nerves and muscles are working. For the nerve part, small sensors on your skin send brief electrical pulses that can feel like a tingle or quick shock. For the EMG part, a doctor places a thin needle in a few muscles to record their activity, which can be uncomfortable and leave a sore spot. Plan on about 30–60 minutes.

Skip lotions and oils that day. Tell the team about your medicines, any pacemaker or implanted device, and any bleeding problems. Don’t stop blood thinners on your own. The doctor will go over the findings or send them to us, and [clinician or team] will review them with you by [date].

Clinical reference

  • Give the clinical question (carpal tunnel, radiculopathy, polyneuropathy, muscle disease) and the symptom distribution. A normal study can occur despite nerve damage, so interpret it with the exam.
  • AANEM: don’t routinely stop anticoagulants or antiplatelets for needle EMG or defer the test; use caution with platelets under 50,000 or INR above 1.5–2.0. Note pacemakers and other implanted devices.

Before ordering

Review anticoagulant and antiplatelet use, bleeding disorders or low platelets, implanted devices (pacemaker, defibrillator, stimulator) and other medicines. Specify the clinical question so the examiner can tailor the study.

Warning signs

Mild soreness or bruising at needle sites is common. Increasing swelling, severe pain or new numbness near a needle site, especially on anticoagulants, needs prompt assessment for a hematoma.

Follow-up

Obtain the report, review it with the patient and act on it: treatment, surgical or neurology referral, or further neuropathy work-up. A normal study doesn’t exclude nerve damage.

Sources

Checked October 15, 2026.

Allergy testing

What to say

An allergist can test whether you’re allergic to things like pollen, pets, foods or penicillin. In skin prick testing, tiny drops go on your skin, and a reaction shows as an itchy bump within about 20 minutes. Some people have a blood test instead. A positive test alone doesn’t prove an allergy, so we read results with your history. Many people labeled allergic to penicillin aren’t, and testing can safely clear that label.

Medicines with antihistamines, including many allergy, cold and sleep products, can blur skin tests. The allergist will tell you what to stop and when; don’t stop other medicines on your own. Severe reactions are very rare, and the office is prepared to treat them. [Clinician or team] will review the results with you by [date].

Clinical reference

  • Refer when the history suggests IgE-mediated allergy (rhinitis or asthma triggers, food, venom, penicillin). Avoid broad IgE panels without a history; positive tests can show sensitization without allergy, especially for foods.
  • About 10% of US patients report a penicillin allergy and under 1% are truly allergic. Low-risk histories can be evaluated by skin testing or supervised oral amoxicillin challenge; refer high-risk histories and severe delayed reactions.

Before ordering

Document the reaction: timing, symptoms, treatment, and any anaphylaxis or severe delayed skin reaction. Review antihistamine use; asthma inhalers, montelukast and nasal steroids needn’t be stopped.

Warning signs

Throat or tongue swelling, trouble breathing, repeated vomiting or fainting after a food, sting or drug is an emergency (911; epinephrine if prescribed). Don’t wait for testing.

Follow-up

Obtain the allergist’s results and written plan. Update the allergy list, including removing a penicillin label after a negative evaluation, and review avoidance steps, medicines and any epinephrine prescription.

Sources

Checked October 15, 2026.

Hearing test

What to say

A hearing test, or audiogram, shows how softly you can hear different pitches. An audiologist has you wear headphones, press a button when you hear beeps, and repeat spoken words. It takes up to an hour and doesn’t hurt. If earwax is blocking your ear, we may need to clear it first. The results show what kind of hearing loss you have and how much.

Over-the-counter hearing aids are now sold for adults with mild to moderate hearing loss, but talk with us first if you have ear pain or drainage, dizziness with hearing loss, or hearing loss in only one ear. Sudden hearing loss is urgent: call us the same day, or go to urgent care or the emergency department. We’ll review your results with you by [date].

Clinical reference

  • Order audiology (pure-tone and speech audiometry) after otoscopy. Medical evaluation is needed for sudden or fast-worsening loss (urgent), asymmetric loss or tinnitus, vertigo, ear pain or drainage, or fluctuating loss.
  • OTC hearing aids (FDA rule finalized August 2022) are for adults 18 and older with perceived mild to moderate loss. Original Medicare Part B covers a diagnostic hearing exam a clinician orders, but not hearing aids or fitting exams.

Before ordering

Examine the ears for wax, effusion or perforation first. Ask about onset, one-sided symptoms, tinnitus, vertigo, noise exposure, ototoxic medicines and prior ear disease.

Warning signs

Sudden or quickly worsening hearing loss needs same-day evaluation. Hearing loss with vertigo, ear drainage or pain, or loss or tinnitus in one ear only, also needs prompt medical assessment.

Follow-up

Review the audiogram with the patient and choose the next step: wax removal, medical or ENT evaluation, hearing aids or other devices. Refer asymmetric, sudden or fluctuating loss to ENT.

Sources

Checked October 15, 2026.

Genetic counseling referral

What to say

A genetic counselor is a trained health professional who helps you understand how your family’s health history may affect you. They’ll review your family history, explain whether testing for inherited conditions, such as some cancers or heart disease, makes sense, and discuss costs and insurance coverage. If you test, they’ll help you understand the results and what they could mean for your relatives.

Bring what you know about relatives’ diagnoses and ages. A federal law called GINA keeps health insurers and most employers from using your genetic results against you, but it doesn’t cover life, disability or long-term care insurance, so ask about that before testing. Many counselors offer phone or video visits, and they’ll tell you when to expect results. We’ll follow up with you by [date].

Clinical reference

  • USPSTF (2019): for women with a personal or family history of breast, ovarian, tubal or peritoneal cancer, or associated ancestry, use a brief familial risk tool; refer positives for genetic counseling.
  • Send the pedigree, relevant pathology and any prior genetic reports. GINA doesn’t cover life, disability or long-term care insurance; counselors discuss this before testing.

Before ordering

Collect a three-generation family history (relatives, diagnoses, ages) and any prior genetic results. Confirm coverage and whether the visit can be done by telehealth.

Warning signs

Distress about results or relatives’ risk is common; offer follow-up support. Don’t use a negative or uncertain result to stop screening that the family history alone would justify.

Follow-up

Confirm the visit happens, then obtain the counselor’s note and results. Update the family history and screening plan, and help the patient share relevant results with relatives.

Sources

Checked October 15, 2026.

Joint or tendon steroid injection

What to say

A steroid injection puts a strong anti-inflammatory medicine where it hurts. It doesn’t cure the problem, but it can ease pain for 2 months or longer, giving you a window to do your exercises. It may take up to a week to work. We clean the skin, often numb it, and inject, which takes a few minutes.

Pain can flare the first day but usually settles in a couple of days. Go easy on the area for 2 weeks. If you have diabetes, check your blood sugar more often for a few days, since it may run high. The skin can thin or lighten at the site. We usually limit injections to 3 a year in one spot. Get same-day care for a hot, red, more painful area or fever.

Clinical reference

  • Aim is short-term relief to enable rehabilitation, not cure. Common sites: knee OA, subacromial or frozen shoulder, trigger finger, de Quervain tenosynovitis, carpal tunnel. Document drug, dose, site, guidance method and consent.
  • Limit to about 3 injections per site per year. Avoid intratendinous injection (rupture risk) and injecting through infected skin or into a possibly septic joint.

Before ordering

Exclude skin infection at the site, septic arthritis, bacteremia and a prosthetic joint. Check diabetes control, bleeding disorders or anticoagulation, anesthetic allergy, and prior injection count and response.

Warning signs

Septic arthritis (hot, swollen joint, fever, pain worsening after 48 h), hyperglycemia for several days in diabetes, skin depigmentation or fat atrophy, tendon rupture.

Follow-up

Reassess function after 4–6 weeks and keep rehab going. If 1–2 injections don’t help, reconsider the diagnosis or refer rather than repeating.

Sources

Checked October 15, 2026.

Skin biopsy

What to say

A skin biopsy removes a small piece of skin so a lab can look at it under a microscope. We numb the area first with a small injection, which stings briefly. A shave biopsy takes off the top layers and doesn’t need stitches. A punch biopsy removes a small round core and may need a stitch or two. It takes a few minutes.

Follow your wound-care sheet. Usually that means washing gently each day, then petroleum jelly and a bandage until it heals. If you have stitches, they usually come out in 3–14 days. For bleeding, press firmly for 10 minutes. Call us about spreading redness, swelling, pus, worsening pain or fever. Expect a small scar. Results often take a week or more; [team] will contact you by [date].

Clinical reference

  • Match technique to the question: shave for raised or superficial lesions; punch for rashes and full-thickness sampling; excision when the whole lesion should come out. Sample the whole lesion when melanoma is suspected, or refer.
  • On the requisition, give site, lesion description, history and differential diagnosis. For rashes, send a separate specimen for culture or other studies when needed.

Before ordering

Confirm consent and the site (photograph it). Ask about anticoagulants, lidocaine allergy, keloids, poor healing (diabetes, lower leg) and implanted devices if using electrocautery.

Warning signs

Infection, bleeding, wound opening, slow healing on the lower leg, hypertrophic scar or keloid. A benign result that doesn’t fit the clinical picture may reflect sampling error.

Follow-up

Track pathology to the patient and arrange suture removal (about 3–14 days by site). Arrange excision, treatment or dermatology referral for malignant, atypical or nondiagnostic results.

Sources

Checked October 15, 2026.

Home blood pressure monitoring

What to say

Home readings often show your usual blood pressure best. Use a validated upper-arm cuff that fits your arm (see validatebp.org), not a wrist cuff or smartwatch. For 30 minutes before, don’t eat, smoke, exercise or have caffeine. Empty your bladder, then sit quietly for 5 minutes, back supported, feet flat, bare arm resting on a table at heart level.

Take 2 readings 1 minute apart each morning, before medicines, and each evening for 7 days before [date]; share them with [team]. An average of 130/80 or higher is above goal. If a reading is over 180 on top or 120 on the bottom, rest and recheck; if it stays that high, call us today. With chest pain, breathlessness, weakness, numbness, trouble speaking or vision changes, call 911.

Clinical reference

  • Use home readings to confirm hypertension (white-coat or masked) and to titrate treatment: 2 readings 1 minute apart, morning and evening, for 7 days, starting about 2 weeks after a medication change; average all readings.
  • A home average ≥130/80 meets stage 1 hypertension or is above the <130/80 goal. Recommend a validated upper-arm device sized to measured arm circumference; avoid cuffless devices and smartwatches.

Before ordering

Confirm the device is validated and the cuff fits the measured mid-arm circumference; compare it with an office reading. Use a wrist cuff only if an upper-arm cuff can’t fit.

Warning signs

>180/120 with chest pain, dyspnea, neurologic deficit, vision change or confusion suggests hypertensive emergency: 911. Without symptoms, same-day contact and prompt outpatient treatment (2025 AHA/ACC). Ask about dizziness or low readings after changes.

Follow-up

Review the weekly average with office readings to classify white-coat, masked or sustained hypertension. Adjust treatment about monthly toward <130/80, repeating a 7-day series after each change and before visits.

Sources

Checked October 15, 2026.

Results

Abnormal liver tests

What to say

Some of your liver tests are high. Mild rises are common and usually aren’t serious. ALT and AST rise when liver cells are irritated; alkaline phosphatase and bilirubin can point to bile flow problems. Causes include fatty liver, alcohol, medicines, supplements, hepatitis and hard workouts.

We’ll recheck by [date] and may test for hepatitis, iron overload, thyroid or celiac disease, or order an ultrasound. Skip alcohol and supplements, but don’t stop prescribed medicines without asking. Get same-day care for yellow skin or eyes, confusion, unusual bleeding, or severe belly pain.

Clinical reference

Before explaining

Classify pattern (R ratio) and degree (× ULN). Review alcohol, medicines, supplements and metabolic risk; check HBsAg, HCV antibody, iron studies.

Warning signs

ALT/AST >15× ULN (or >1,000), jaundice, raised INR or confusion: same-day evaluation; ask about acetaminophen.

Follow-up

Raised ALP: GGT, then RUQ ultrasound. Persistent ALT/AST: extend workup (autoimmune, Wilson if young, A1AT, celiac, TSH, CK) or refer to hepatology.

Sources

Checked October 15, 2026.

Elevated PSA

What to say

Your PSA, a prostate protein, is higher than expected. That doesn’t necessarily mean cancer. An enlarged prostate, infection or inflammation, or a recent catheter or procedure can raise it. Many prostate cancers found this way grow so slowly they’d never cause harm.

We’ll repeat it by [date]; it’s often normal the second time. If it stays high, next steps may include an MRI, a urologist visit or a biopsy. Get same-day care for fever with urinary pain or if you can’t pass urine, and tell us about bone pain.

Clinical reference

Before explaining

Confirm with a repeat PSA before MRI, biomarkers or biopsy; review UTI, retention, recent instrumentation and 5-ARI use (including for hair loss).

Warning signs

Don’t treat asymptomatic PSA elevation with antibiotics. Bone pain, weight loss or very high PSA needs prompt workup; back pain with leg weakness is an emergency.

Follow-up

Persistently elevated: risk calculator, prostate MRI and urology referral. 5-ARIs lower PSA after ≥6 months; doubling it is only approximate.

Sources

Checked October 15, 2026.

High bilirubin and Gilbert syndrome

What to say

Your bilirubin is mildly high, but your liver enzymes and blood count are normal. This is usually Gilbert syndrome, a harmless inherited trait in 3 to 7 in 100 people. Fasting, illness or stress can raise it and tint the eyes yellow.

It needs no treatment and doesn’t harm your liver. Tell new prescribers about it. Get same-day care for dark urine, pale stools, belly pain, or deeper yellow skin.

Clinical reference

Before explaining

Fractionate bilirubin; if indirect-predominant with normal AST, ALT, ALP and CBC and no hemolysis, diagnose Gilbert syndrome clinically.

Warning signs

Direct hyperbilirubinemia, abnormal enzymes, anemia or hemolysis, dark urine, pale stools, or jaundice with pain or fever need workup.

Follow-up

No treatment or routine follow-up; reduced UGT1A1 activity affects some drugs (e.g., irinotecan dosing); reassess if tests or symptoms change.

Sources

Checked October 15, 2026.

High calcium level

What to say

Your calcium level came back high. One result can be off, so we’ll repeat it with a parathyroid hormone (PTH) level. The most common cause is an overactive parathyroid gland, which is usually benign; supplements, some water pills, lithium and, less often, cancer can also raise it.

Until then, drink plenty of water and pause calcium and vitamin D supplements, but keep eating normally. We’ll recheck by [date]. Get same-day care for confusion, vomiting, severe thirst or weakness.

Clinical reference

Before explaining

Repeat Ca with albumin or ionized Ca, plus PTH, creatinine, phosphate and 25-OH vitamin D; review supplements, thiazides and lithium.

Warning signs

Symptoms, AKI, Ca >13 mg/dL or low PTH (suggests a non-PTH cause such as malignancy): same-day assessment.

Follow-up

If PTH-mediated: 24-h urine Ca, DXA, kidney imaging; refer for surgery if Ca >1 mg/dL above ULN, osteoporosis, fragility fracture, stones or age <50.

Sources

Checked October 15, 2026.

High ferritin

What to say

Ferritin stores iron, but it also rises with inflammation, fatty liver, alcohol, obesity and infection. Most high results aren’t from too much iron. Less often, an inherited condition called hemochromatosis is the cause.

We’ll check your iron saturation and liver tests, and maybe a gene test. Until we review, avoid iron and vitamin C supplements. Get same-day care for yellow skin or belly swelling, and tell us about joint pain.

Clinical reference

Before explaining

Check transferrin saturation, liver tests, alcohol use and inflammation; HFE testing if saturation stays above 45% (women) or 50% (men).

Warning signs

With confirmed iron overload, ferritin >1,000 µg/L or abnormal enzymes raises concern for fibrosis; screen for diabetes, arthropathy, cardiomyopathy.

Follow-up

If HFE iron overload is confirmed: phlebotomy and testing of adult first-degree relatives; otherwise treat the underlying cause and recheck ferritin.

Sources

Checked October 15, 2026.

High lipoprotein(a)

What to say

Lp(a) is a cholesterol particle set mostly by your genes. A level of about 50 milligrams per deciliter or more raises lifetime heart attack and stroke risk, but doesn’t mean you’ll have one.

No medicine is yet proven to prevent heart attacks by lowering Lp(a), so we’ll treat other risks more intensively, especially LDL cholesterol. Parents, siblings and children can be tested. Call 911 for chest pain or stroke symptoms.

Clinical reference

Before explaining

Measure once; ≥125 nmol/L (≈50 mg/dL) is high risk. Review LDL-C, BP, glucose, smoking and family history.

Warning signs

Chest pain, stroke symptoms or claudication need urgent evaluation; premature ASCVD or very high Lp(a) merits lipid-clinic referral.

Follow-up

Treat other risks intensively; Lp(a)-lowering drugs remain investigational (pelacarsen missed its primary endpoint, Sept 2026); test first-degree relatives.

Sources

Checked October 15, 2026.

Low neutrophil count

What to say

Neutrophils are white blood cells that fight germs. A mildly low count is common and often harmless. Some people, especially those of African or Middle Eastern ancestry, normally run lower with no added infection risk.

We’ll repeat the count in a few weeks and review your medicines and recent infections. Call us right away for a temperature of 100.4°F (38°C) or higher, mouth sores, or repeated infections.

Clinical reference

Before explaining

Repeat CBC with differential; review medicines, B12 and folate; consider Duffy-null variant; ANC <500 or fever needs urgent evaluation.

Warning signs

Fever with a low ANC needs same-day evaluation; mouth ulcers, recurrent infections, other cytopenias or ANC <500 need prompt hematology input.

Follow-up

Recheck in a few weeks; if persistent, evaluate causes (limited if Duffy-null and well); refer if ANC falls, other counts are abnormal, or infections recur.

Sources

Checked October 15, 2026.

MGUS (monoclonal protein)

What to say

MGUS means your blood has a small amount of abnormal protein from plasma cells. It’s not cancer and is common, affecting about 3 in 100 people over 50. Yearly, 1 in 100 or fewer develop myeloma or a related condition.

We’ll recheck your blood in about 6 months, then every 1 to 3 years. Call us sooner for new bone pain, unusual tiredness, numbness, frequent infections, or weight loss.

Clinical reference

Before explaining

Check SPEP, free light chains, CBC, calcium, creatinine; exclude myeloma; risk-stratify by M-protein ≥1.5 g/dL, non-IgG isotype, abnormal FLC ratio.

Warning signs

New bone pain or fracture, anemia, hypercalcemia, kidney dysfunction, neuropathy, weight loss or recurrent infection suggests progression or amyloidosis.

Follow-up

Low risk: repeat labs at 6 months, then every 2–3 years. Higher risk: marrow evaluation, then yearly labs.

Sources

Checked October 15, 2026.

Mildly high TSH

What to say

Your TSH, the brain’s signal to the thyroid, is a little high, but your thyroid hormone level (free T4) is normal. This is called subclinical hypothyroidism. It often returns to normal, TSH runs higher with age, and treatment usually doesn’t help when TSH is under 10.

We’ll repeat TSH and free T4 in about 3 months. If you take biotin, tell us, since it can skew results. If you’re pregnant or planning a pregnancy, let us know now; that changes the plan.

Clinical reference

Before explaining

Confirm free T4 is normal; consider recovery from illness, biotin and drugs such as lithium; ask about pregnancy plans.

Warning signs

Low free T4, TSH ≥10 on repeat, goiter or pregnancy changes management.

Follow-up

Repeat TSH and free T4 in about 3 months, with TPO antibodies once; if untreated, recheck yearly if TPO-positive, otherwise every 2–3 years.

Sources

Checked October 15, 2026.

Positive ANA test

What to say

A positive ANA is common: up to 15% of healthy people have one, more often with age. On its own, it doesn’t mean lupus or another autoimmune disease.

What matters is whether you have symptoms like joint swelling, rash, mouth sores, or fingers that turn white in the cold. If not, there’s nothing to treat. If these appear, tell us and we may test further or refer you to rheumatology.

Clinical reference

Before explaining

Interpret ANA with symptoms, titer and pattern; order dsDNA, ENA or other targeted antibodies only when features suggest autoimmune disease.

Warning signs

Joint swelling, rash, mouth ulcers, Raynaud, dry eyes, muscle weakness, or abnormal urine or blood counts warrant rheumatology referral.

Follow-up

No treatment for the number alone; reassess if new symptoms develop, and refer if features of connective tissue disease emerge.

Sources

Checked October 15, 2026.

Bacteria in the urine without symptoms

What to say

Your urine test grew bacteria, but you don’t have symptoms of a bladder infection. This is called asymptomatic bacteriuria. It’s common, especially in older adults and people with catheters, and it usually isn’t harmful.

Antibiotics don’t help here and can cause side effects, resistant germs and a serious diarrhea infection called C. diff, so we won’t treat it unless you’re pregnant or having certain urology procedures. Call us if burning or urgency starts, and the same day for fever, chills, or side or back pain.

Clinical reference

Before explaining

Confirm no genitourinary symptoms and no fever or other systemic signs. Screen and treat only in pregnancy or before mucosa-breaching urologic procedures.

Warning signs

Delirium or a fall without genitourinary or systemic signs: look for other causes and observe rather than treat (IDSA).

Follow-up

Don’t repeat the culture without symptoms. IDSA advises against screening healthy nonpregnant women, older adults, diabetes, catheters and nonurologic surgery.

Sources

Checked October 15, 2026.

Abnormal Pap or positive HPV test

What to say

Your screening found HPV, abnormal cells, or both. This is common and rarely means cancer. HPV most often clears on its own, and cell changes usually take years to become serious. HPV can stay hidden for years, so it doesn’t mean anyone was unfaithful.

Next is usually a repeat test in 1 year or colposcopy, a closer look at the cervix, sometimes with a small biopsy. Keeping this follow-up matters most. Quitting smoking helps, and partners don’t need special testing. Call us about bleeding after sex or between periods.

Clinical reference

Before explaining

Manage by ASCCP risk-based guidelines using current results, HPV genotype and prior history; immediate CIN3+ risk ≥4% means colposcopy.

Warning signs

HPV 16/18, ASC-H, HSIL or AGC: colposcopy (HSIL may get expedited treatment; AGC adds endocervical ± endometrial sampling).

Follow-up

Track colposcopy or 1-year retest to completion; post-colposcopy surveillance per ASCCP; offer HPV vaccine through age 26.

Sources

Checked October 15, 2026.

Dense breasts on a mammogram

What to say

Dense breasts have more gland and fibrous tissue than fat. It’s normal and common: about half of women over 40 have it. Dense tissue can hide some cancers on a mammogram and is linked to a higher chance of breast cancer. Density alone doesn’t mean anything abnormal was found.

Keep getting regular mammograms. We’ll estimate your overall risk to decide whether an extra ultrasound or MRI makes sense, and check insurance coverage, which varies. A new lump or skin change needs prompt diagnostic imaging, whatever your last mammogram showed.

Clinical reference

Before explaining

Heterogeneously or extremely dense tissue triggers the FDA-required patient notice (since September 2024). Assess overall risk with a validated model.

Warning signs

A palpable lump, nipple discharge or skin change needs diagnostic imaging, not screening.

Follow-up

Continue screening. USPSTF: insufficient evidence for routine supplemental ultrasound or MRI based on density alone; individualize by risk. Confirm coverage before ordering.

Sources

Checked October 15, 2026.

Polyps found at colonoscopy

What to say

Polyps are growths on the colon lining. Most aren’t cancer, but some could slowly become cancer, so removing them lowers your risk.

We’ll share the lab results by [date]; call [team] if you haven’t heard. The type, number and size of your polyps set your next colonoscopy, usually in 3 to 10 years, and a stool test can’t replace it. Some results mean relatives should screen earlier. After polyp removal, heavy bleeding, severe belly pain or fever needs urgent care.

Clinical reference

Before explaining

USMSTF 2020: 1–2 tubular adenomas <10 mm, 7–10 y; 3–4, 3–5 y; 5–10, or any ≥10 mm, villous or HGD, 3 y; 1–2 SSPs <10 mm, 5–10 y; small hyperplastic, 10 y.

Warning signs

Post-polypectomy bleeding, pain or fever needs urgent review. >10 adenomas: 1 y and consider genetic testing; piecemeal resection ≥20 mm: 6 months.

Follow-up

Track pathology and set recall. Advanced adenoma before 60: first-degree relatives need colonoscopy every 5 y from 40, or 10 y before this diagnosis age if earlier.

Sources

Checked October 15, 2026.

Incidental finding on a scan

What to say

Your scan showed something we weren’t looking for, called an incidental finding. These are common, and many, like simple kidney or liver cysts, are harmless and need no treatment.

Size, appearance and your health history tell us whether to do nothing, repeat the scan, or order another test. Your finding is [finding], and the plan is [plan]. Call us if you develop new symptoms in that area.

Clinical reference

Before explaining

Match the finding to the ACR white paper for that organ, weighing size, appearance, prior imaging and patient risk.

Warning signs

Growth, irregular margins, solid enhancing components or new symptoms need prompt specialist input; avoid needless repeat imaging.

Follow-up

Document the finding and plan, tell the patient, and track follow-up imaging, specialist referral, or hormone testing for some adrenal nodules.

Sources

Checked October 15, 2026.

Lung nodule on a CT scan

What to say

Your CT scan shows a nodule, a small spot on the lung. These are very common, and most aren’t cancer; many are scars from old infections. Its size and look, plus your smoking history, guide what we do.

Many just need a repeat CT, often 3–12 months later, to check for growth. Some need a PET scan or biopsy; tiny low-risk spots may need nothing. We’ll track your follow-up. If you smoke, quitting helps. Call sooner for coughing up blood or unexplained weight loss.

Clinical reference

Before explaining

Use Fleischner 2017 for incidental nodules (age ≥35, no cancer or immunosuppression); Lung-RADS v2022 for screening CTs.

Warning signs

Solid >8 mm: CT at 3 months, PET/CT or sampling. Growth, spiculation or a solid component ≥6 mm raises concern.

Follow-up

Solid <6 mm, low risk: no routine follow-up. 6–8 mm: CT at 6–12, then 18–24 months. Track to completion; offer cessation.

Sources

Checked October 15, 2026.

Conditions

Joints, muscles & bones

Achilles tendinopathy

What to say

The tendon at the back of your heel is struggling with its current workload. Recovery usually needs a change in load and gradual strengthening.

Reduce running or jumping that flares it and follow a progressive exercise plan suited to the painful part of the tendon. Avoid pushing through a sudden sharp pain.

Clinical reference

Before explaining

Differentiate insertional/midportion disease; examine for rupture and review relevant medicines.

Warning signs

A sudden snap, marked weakness or inability to push off needs urgent assessment for rupture.

Follow-up

Review walking, exercise tolerance and loading progression.

Sources

Checked September 24, 2026.

ACL tear

What to say

The ACL steadies your knee. A tear often follows a pivot or landing, with a pop, swelling and a knee that gives way.

We’ll protect the knee, start physical therapy, and may order an MRI. Surgery depends on how unstable the knee feels and your activity goals. Get same-day care for a locked knee or if you can’t bear weight; go to the emergency department for a numb, cold foot.

Clinical reference

Before explaining

Lachman and pivot-shift tests; X-ray for fracture; MRI for meniscus and other injuries. Ask about activity goals and instability.

Warning signs

Locked knee or inability to bear weight needs same-day evaluation; a numb or cold foot suggests vascular injury (emergency).

Follow-up

Begin physical therapy for motion and quadriceps strength; refer to orthopedics for instability, high activity demands or associated injuries.

Sources

Checked October 15, 2026.

Acute low back pain

What to say

Your assessment today supports starting with movement and symptom relief. I don’t see a reason for routine imaging right now. An early scan often shows changes that don’t explain the pain or improve the treatment.

Try to keep moving within what you can tolerate, rather than spending the day in bed. We’ll choose safe pain relief and a simple activity goal, such as walking for a few minutes several times a day. If you develop new leg weakness, numbness around the groin, or trouble controlling or emptying your bladder or bowel, go to the emergency department. Otherwise, we’ll check whether your movement and function are improving, and change the plan if they aren’t.

Clinical reference

  • Encourage activity/self-management and consider exercise-based PT for functional limitation or difficulty progressing.
  • Choose analgesia after renal/GI/CV/pregnancy and interaction review. No routine imaging in an uncomplicated non-specialist presentation.

Before explaining

Assess trauma, cancer/infection risk, osteoporosis/steroid exposure, neurologic deficit, saddle sensation and bladder/bowel function. Reassuring wording must follow an actual assessment.

Warning signs

Cauda-equina symptoms or progressive motor weakness needs emergency evaluation. Suspected fracture, infection or malignancy needs directed timely workup.

Follow-up

Agree on a functional measure and review in roughly 2–4 weeks for a stable uncomplicated case, earlier if severe or worsening. Review sooner when the course is atypical.

Sources

Checked September 20, 2026.

Ankle sprain

What to say

The ligaments supporting your ankle have been stretched or injured. Swelling and bruising are common, but we first check whether a fracture is likely.

Protect it early, use the support and swelling measures we discussed, and gradually restore walking, motion and balance as tolerated. Returning to sport too quickly can cause another sprain.

Clinical reference

Before explaining

Assess bony tenderness, weight-bearing ability, stability and neurovascular status; image when indicated.

Warning signs

Deformity, a cold/numb foot or inability to bear weight needs urgent review.

Follow-up

Reassess if walking and swelling are not improving; plan rehabilitation before sport.

Sources

Checked September 24, 2026.

Baker cyst

What to say

A pocket of joint fluid has formed behind the knee. It often reflects another knee problem, such as arthritis or a meniscal injury.

Treatment focuses on the knee problem and comfortable movement. If the calf suddenly swells or becomes painful, get it checked promptly because a ruptured cyst and a blood clot can feel similar.

Clinical reference

Before explaining

Examine knee and popliteal swelling; assess DVT probability when calf symptoms occur.

Warning signs

Sudden calf swelling needs same-day assessment; chest pain or breathlessness means call 911.

Follow-up

Review persistent pain or restricted motion and the underlying knee condition.

Sources

Checked September 24, 2026.

Bunion

What to say

A bunion is a change in the position of the big-toe joint. Shoes pressing on it can make the area painful.

Wider shoes and pressure relief can help symptoms, though they don’t straighten the joint. Surgery is an option when pain keeps limiting daily life despite these measures.

Clinical reference

Before explaining

Assess footwear, skin, circulation, toe motion and inflammatory joint disease.

Warning signs

A suddenly red, hot joint or an open/infected sore needs prompt review.

Follow-up

Review persistent pain or difficulty finding usable footwear.

Sources

Checked September 24, 2026.

Calcium pyrophosphate arthritis

What to say

Calcium crystals can inflame a joint suddenly, often a knee or wrist. This is sometimes called pseudogout.

A fluid sample may help distinguish it from gout or infection. Treatment can calm inflammation, but there’s no medicine that reliably removes these crystals.

Clinical reference

Before explaining

Assess septic arthritis; consider aspiration and associated metabolic disorders when appropriate.

Warning signs

Fever, a very painful hot joint or inability to bear weight requires urgent assessment.

Follow-up

Review response and recurrent attacks; reassess if the expected improvement does not occur.

Sources

Checked September 24, 2026.

Carpal tunnel syndrome

What to say

A nerve is being squeezed at the wrist, which can cause nighttime tingling in the thumb and nearby fingers.

A wrist splint that keeps the wrist straight at night may help. We’ll review activities and discuss an injection or specialist treatment if symptoms persist, especially if the hand becomes weak.

Clinical reference

Before explaining

Map sensory symptoms; assess thumb strength and alternative nerve compression.

Warning signs

Constant numbness, dropping objects or thumb weakness needs earlier review.

Follow-up

Review response to splinting; consider nerve testing or referral for persistent/severe symptoms.

Sources

Checked September 24, 2026.

Chest-wall pain (costochondritis)

What to say

Costochondritis is inflammation where ribs join the breastbone, causing sharp pain that’s worse with movement, deep breaths or pressure. It isn’t dangerous and usually settles within weeks to months.

Heat or ice, anti-inflammatory medicine if it’s safe for you, and avoiding straining activities can help. Tender ribs don’t rule out a heart problem: call 911 for chest pressure, pain spreading to your arm or jaw, or pain with breathlessness, sweating or faintness.

Clinical reference

Before explaining

Exclude cardiopulmonary causes first; reproducible tenderness doesn’t rule out ACS. Consider ECG and chest x-ray if over 35 or at cardiac risk.

Warning signs

Exertional or radiating pain, dyspnea, sweating or syncope needs emergency care; fever or focal swelling suggests infection or other pathology.

Follow-up

Expect gradual improvement over weeks to months; reassess if pain worsens, persists or develops atypical features.

Sources

Checked October 15, 2026.

Chronic low back pain

What to say

Back pain lasting more than 12 weeks is called chronic. It’s common and rarely a sign of serious damage.

Staying active helps. Exercise or physical therapy comes first; yoga, tai chi, acupuncture or pain coping skills can add relief. Anti-inflammatory medicine or duloxetine helps some people, and we try to avoid long-term opioids. Go to the emergency department for new leg weakness, numbness around the groin or bottom, or bladder or bowel changes.

Clinical reference

Before explaining

Screen for red flags (cancer, infection, fracture, neurologic deficit); review function, mood, sleep, work and prior treatments.

Warning signs

Cauda equina symptoms or progressive weakness need emergency care; fever, unintended weight loss or cancer history need prompt workup.

Follow-up

Agree on function goals; if progress stalls, add supervised exercise, CBT, spinal manipulation or multidisciplinary rehabilitation.

Sources

Checked October 15, 2026.

Cubital tunnel syndrome

What to say

The nerve near the inside of your elbow is irritated. This often causes tingling in the little finger and part of the ring finger.

Avoid leaning on the elbow or keeping it tightly bent for long periods. We can discuss a nighttime support and further testing if numbness or weakness continues.

Clinical reference

Before explaining

Assess ulnar sensation, grip, intrinsic hand strength and neck/wrist causes.

Warning signs

Progressive weakness, muscle wasting or persistent sensory loss warrants prompt referral.

Follow-up

Review symptoms after reducing pressure and prolonged flexion.

Sources

Checked September 24, 2026.

De Quervain tenosynovitis

What to say

The tendons near the thumb side of your wrist are irritated, making lifting, twisting or moving your thumb painful.

We’ll adapt the movements that trigger it and consider a splint supporting both wrist and thumb. If that isn’t enough, an injection or hand specialist may help.

Clinical reference

Before explaining

Localize radial wrist pain; assess injury, thumb arthritis and medication safety.

Warning signs

Redness, fever or pain after significant trauma needs reassessment.

Follow-up

Review pain with lifting and thumb motion after the treatment trial.

Sources

Checked September 24, 2026.

Dupuytren contracture

What to say

Tissue under the palm has thickened into cords that can pull a finger inward. This usually develops gradually.

If your hand still works well, observation may be enough. If straightening the finger becomes difficult or tasks are affected, a hand specialist can discuss procedures. Recurrence is possible.

Clinical reference

Before explaining

Document extension deficit, tabletop test and function; distinguish trigger finger.

Warning signs

Rapid painful change or an atypical mass needs reassessment.

Follow-up

Review increasing contracture or difficulty putting the hand flat.

Sources

Checked September 24, 2026.

Fibromyalgia

What to say

Fibromyalgia can cause widespread pain, fatigue and unrefreshing sleep. The pain is real, even when routine tests don’t show tissue damage.

We’ll build a manageable plan around sleep, movement you can tolerate and pain coping skills. Medicines may help some symptoms, but progress is usually measured in better function and fewer bad days.

Clinical reference

Before explaining

Assess other explanations, sleep disorders, mood and medication burden; avoid attributing every new symptom to fibromyalgia.

Warning signs

New focal weakness, fever, joint swelling or unexplained weight loss needs separate evaluation.

Follow-up

Choose a small functional goal and review benefit and side effects of treatment.

Sources

Checked September 24, 2026.

Frozen shoulder

What to say

Frozen shoulder causes pain and a real loss of shoulder movement, even when someone else helps move your arm. Recovery can take months and sometimes longer.

We’ll work on pain control and gentle stretching matched to the stage of the problem. Physical therapy or an injection may help. Forcing painful movements can make the shoulder more irritated.

Clinical reference

Before explaining

Confirm restriction of passive and active motion; consider arthritis, diabetes and thyroid disease.

Warning signs

New fever, redness or sudden weakness after injury needs reassessment.

Follow-up

Review sleep, pain and range of motion; reconsider the diagnosis if the pattern changes.

Sources

Checked September 24, 2026.

Ganglion cyst

What to say

This appears to be a fluid-filled swelling from a joint or tendon lining. Ganglion cysts are usually harmless and may change size.

If it isn’t painful or limiting movement, we can watch it. Persistent symptoms may justify treatment, but cysts can return. Don’t hit or puncture it yourself.

Clinical reference

Before explaining

Confirm typical location and consistency; reassess solid, fixed or unusual masses.

Warning signs

Redness, marked pain, rapid growth or nerve symptoms warrants review.

Follow-up

Return for growth, uncertainty or interference with function.

Sources

Checked September 24, 2026.

Golfer’s elbow

What to say

The tendon on the inside of your elbow is irritated, often from repeated gripping or wrist bending.

We’ll reduce the load that keeps aggravating it and gradually rebuild the tendon’s tolerance with exercises. Tell me if you also have tingling in the ring or little finger, which may point to a nearby nerve problem.

Clinical reference

Before explaining

Examine medial tenderness, resisted wrist flexion and ulnar nerve function.

Warning signs

New weakness, persistent numbness, trauma or redness requires reassessment.

Follow-up

Review pain with work and gripping after the exercise trial.

Sources

Checked September 24, 2026.

Gout

What to say

Gout happens when urate crystals trigger sudden joint inflammation. The flare can be very painful, but treatments can settle it.

We’ll choose flare treatment that’s safe for your kidneys and other medicines. If attacks recur or other risk factors apply, long-term urate-lowering treatment can prevent future episodes.

Clinical reference

Before explaining

Consider joint aspiration if uncertain; infection can coexist. Review renal function, interactions and urate outside the flare.

Warning signs

A first hot swollen joint, fever or feeling very ill needs urgent assessment; do not assume every flare is gout.

Follow-up

Review flare resolution and whether preventive treatment and urate monitoring are needed.

Sources

Checked September 24, 2026.

Greater trochanteric pain syndrome

What to say

Pain over the outside of the hip often comes from irritated tendons and nearby cushioning tissues. Lying on that side or climbing stairs may aggravate it.

We’ll reduce pressure on the sore side and build hip strength gradually. A pillow between the knees may help at night. Persistent symptoms may need physical therapy or another treatment.

Clinical reference

Before explaining

Distinguish lateral tenderness from groin arthritis, lumbar referral and fracture.

Warning signs

Inability to bear weight, fever or pain after a significant fall needs urgent assessment.

Follow-up

Review sleep and walking after a rehabilitation trial.

Sources

Checked September 24, 2026.

Hand and thumb osteoarthritis

What to say

Arthritis can make finger joints or the base of the thumb stiff and sore, especially with pinching or gripping.

A thumb support, hand exercises and changes to how you grip objects may help. We can discuss topical pain relief and hand therapy. Persistent loss of function may warrant a specialist opinion.

Clinical reference

Before explaining

Identify affected joints, inflammatory swelling, nerve symptoms and functional goals.

Warning signs

Rapid redness, warmth, fever or a swollen joint after injury needs prompt assessment.

Follow-up

Review grip and daily tasks after treatment; reassess persistent swelling.

Sources

Checked September 24, 2026.

Hip osteoarthritis

What to say

Hip arthritis often causes groin pain and stiffness, sometimes felt in the thigh or knee. It can make walking or putting on shoes harder.

We can start with strength and mobility work, suitable pain relief, and a walking aid if helpful. If those measures no longer let you do important activities, we can discuss seeing a surgeon.

Clinical reference

Before explaining

Examine hip and spine; distinguish lateral tendon pain and fracture. Review medication risks.

Warning signs

Sudden severe pain after a fall or inability to stand needs urgent assessment.

Follow-up

Set a walking or dressing goal and review response on [date].

Sources

Checked September 24, 2026.

Hot swollen joint: possible septic arthritis

What to say

A suddenly hot, swollen and very painful joint can be infected. We can’t safely tell from symptoms alone whether this is infection or crystal arthritis.

You need urgent hospital assessment today, often including a sample of joint fluid. Waiting for a routine appointment could allow joint damage or a serious infection to develop.

Clinical reference

Before explaining

Assess sepsis, prosthetic joint, immunosuppression and recent procedures; arrange immediate evaluation.

Warning signs

Confusion, faintness or severe systemic illness means call 911. Absence of fever does not exclude infection.

Follow-up

Arrange direct urgent handoff; follow the hospital culture and treatment plan afterward.

Sources

Checked September 24, 2026.

Joint hypermobility

What to say

Flexible joints are common, and many people have no problems. If they cause pain, slipping joints or tiredness, we call it symptomatic hypermobility; some people have hypermobile Ehlers-Danlos syndrome.

Physical therapy for strength and joint control helps most, along with pacing your activity and avoiding overstretching. Tell us about easy bruising, thin skin, or relatives with sudden death or blood vessel tears, since those need a genetics review.

Clinical reference

Before explaining

Beighton score and joint history; look for vascular EDS signs (thin skin, easy bruising, family sudden death); screen for POTS.

Warning signs

Sudden severe chest, abdominal or neck pain, or a spontaneous arterial or bowel rupture, is an emergency; consider vascular EDS.

Follow-up

Physical therapy for strength and proprioception; reassess pain, function and related symptoms; genetics referral if features suggest another EDS type.

Sources

Checked October 15, 2026.

Knee osteoarthritis

What to say

Arthritis changes the cushioning and other tissues in the knee. Pain can fluctuate. An X-ray alone doesn’t tell us how much you should hurt or what you can do.

We’ll build a tolerable strengthening and walking plan, consider pain relief, and track stairs or another activity that matters to you. If symptoms keep limiting you, we can discuss injections or a joint-replacement assessment.

Clinical reference

Before explaining

Assess gait, range, swelling, trauma and inflammatory features; individualize NSAID safety and weight discussion.

Warning signs

A suddenly hot, swollen knee, fever or inability to bear weight needs urgent assessment.

Follow-up

Review pain and function after the agreed rehabilitation trial; refer for persistent major limitation.

Sources

Checked September 24, 2026.

Lumbar spinal stenosis

What to say

Narrowing around the nerves in the lower back can cause leg pain or heaviness with standing and walking, often easing when you sit or lean forward.

We’ll work on a safe exercise and walking plan and discuss symptom relief. If walking stays very limited or weakness develops, specialist assessment may help.

Clinical reference

Before explaining

Distinguish neurogenic from vascular claudication; document pulses and neurologic examination.

Warning signs

New retention, saddle numbness, bowel-control loss or progressive weakness needs emergency assessment.

Follow-up

Track walking distance and daily function; review referral options if limiting.

Sources

Checked September 24, 2026.

Meniscal injury

What to say

The meniscus is a pad of cartilage in the knee. An injury or gradual changes can cause pain, catching or swelling.

Many people improve with rehabilitation and activity adjustment. Whether imaging or surgery would help depends on the examination and symptoms. A tear on a scan alone doesn’t settle that decision.

Clinical reference

Before explaining

Assess trauma, effusion, joint-line tenderness, instability and true mechanical locking.

Warning signs

A knee that cannot straighten, major swelling or inability to bear weight needs prompt review.

Follow-up

Reassess function after rehabilitation; expedite a truly locked knee.

Sources

Checked September 24, 2026.

Morton neuroma

What to say

A nerve between the toes is irritated, which can feel like burning, tingling or a pebble under the foot.

Try wider shoes with a lower heel and the pressure-relieving pad we discussed. If pain continues, we can consider an injection or foot specialist.

Clinical reference

Before explaining

Localize forefoot symptoms; assess footwear, sensation and alternative causes.

Warning signs

Persistent numbness, a wound or new inability to bear weight warrants review.

Follow-up

Reassess walking comfort after footwear changes.

Sources

Checked September 24, 2026.

Muscle strain

What to say

A strain is a stretched or torn muscle, often in the hamstring, calf or groin. Most feel better within a few weeks.

Rest it a few days, use ice rather than heat, and take acetaminophen for pain. Then restart gentle movement and build strength, returning to sport gradually. Get seen soon for a pop, a large bruise or dent, or if you can’t put weight on the leg.

Clinical reference

Before explaining

Examine for tendon rupture or avulsion (pop, palpable gap, marked bruising, weakness); consider imaging if severe or atypical.

Warning signs

Pop, palpable gap, large bruise, weakness or inability to bear weight suggests rupture; calf swelling or redness suggests DVT.

Follow-up

Reassess in 1–2 weeks; NSAIDs optional, short course; progress to strengthening and graded return to sport; PT if slow.

Sources

Checked October 15, 2026.

Neck pain and cervical radiculopathy

What to say

Neck joints and muscles can become painful, and an irritated nerve may send pain or tingling into the arm.

If the examination shows no concerning nerve damage, we can start with comfortable movement, physical therapy and suitable pain relief. Tell me promptly if strength or coordination changes.

Clinical reference

Before explaining

Document arm strength/reflexes/sensation; assess trauma, myelopathy, infection and cancer features.

Warning signs

New hand clumsiness, walking difficulty, progressive weakness or bowel/bladder changes needs urgent assessment.

Follow-up

Recheck neurologic findings and function; escalate persistent or progressive symptoms.

Sources

Checked September 24, 2026.

Night leg cramps

What to say

Night leg cramps are sudden, painful tightening of a calf muscle, lasting seconds to several minutes. They’re very common, and most have no clear cause.

Stretch your calves before bed, and stretch or massage the muscle during a cramp. We’ll review your medicines. We avoid quinine, which can cause dangerous blood problems. Get same-day care for a swollen, red or painful calf, and tell us about leg weakness or numbness.

Clinical reference

Before explaining

Review medicines (raloxifene, estrogens, teriparatide, naproxen, IV iron; diuretics, statins often blamed); examine pulses and nerves; routine electrolytes unnecessary.

Warning signs

Unilateral calf swelling or redness needs DVT evaluation; weakness, numbness or exertional calf pain needs vascular or neurologic workup.

Follow-up

Reassess after a few weeks of stretching and medication changes; avoid quinine; magnesium has little proven benefit.

Sources

Checked October 15, 2026.

Olecranon bursitis

What to say

The fluid cushion over the tip of your elbow is swollen. Pressure or a knock can cause this, but infection can look similar.

If the examination supports a noninfected swelling, avoid leaning on the elbow and use protection and the comfort measures we discussed. Don’t try to drain it yourself.

Clinical reference

Before explaining

Check warmth, skin breaks, fever and range; consider infection or gout before injection.

Warning signs

A red, hot, increasingly painful swelling or fever needs same-day assessment.

Follow-up

Recheck persistent or enlarging swelling; arrange aspiration if diagnostically indicated.

Sources

Checked September 24, 2026.

Osteoporosis

What to say

Osteoporosis makes bones more likely to break, sometimes after a small fall. It often causes no warning symptoms.

We’ll assess your fracture risk and discuss bone-protecting treatment, nutrition, strength and balance work. The aim is to prevent fractures while keeping you active.

Clinical reference

Before explaining

Review fracture history, bone density, secondary causes, renal function, calcium/vitamin D and treatment suitability.

Warning signs

New severe back or hip pain after minor injury needs prompt assessment.

Follow-up

Set a medication-specific monitoring plan and review falls and treatment adherence.

Sources

Checked September 24, 2026.

Patellofemoral pain

What to say

Pain around or behind the kneecap can happen when the joint is loaded during stairs, squatting or prolonged sitting.

Temporarily adjust the activities that flare it, then build hip and thigh strength. Recovery usually depends on a consistent exercise plan and gradually increasing activity.

Clinical reference

Before explaining

Assess alignment, patellar tracking, training changes and swelling; exclude other knee pathology.

Warning signs

A large sudden swelling, locking or inability to bear weight needs reassessment.

Follow-up

Review activity tolerance and exercise progression on [date].

Sources

Checked September 24, 2026.

Plantar fasciitis

What to say

The band under your foot is irritated near the heel. Pain is often worst with the first steps after resting.

Supportive shoes, reducing prolonged standing or impact, and regular calf and foot stretches may help. Recovery is often gradual, so we’ll track walking comfort rather than expect an overnight change.

Clinical reference

Before explaining

Confirm plantar heel tenderness; consider fracture, nerve pain and inflammatory disease.

Warning signs

New inability to bear weight, redness, fever or numbness needs review.

Follow-up

Reassess persistent pain despite the agreed footwear and exercise plan.

Sources

Checked September 24, 2026.

Polymyalgia rheumatica

What to say

This condition causes aching and stiffness around the shoulders and hips, usually in people over 50. Other illnesses can look similar, so the assessment matters.

If the diagnosis fits, steroid treatment often helps, followed by a carefully monitored reduction. Don’t change the dose on your own.

Clinical reference

Before explaining

Assess inflammatory markers and mimics; ask about giant cell arteritis symptoms and plan steroid monitoring.

Warning signs

New headache, scalp tenderness or jaw pain with chewing needs urgent same-day assessment; visual change needs emergency assessment.

Follow-up

Review early treatment response, relapse, adverse effects and bone protection.

Sources

Checked September 24, 2026.

Prepatellar bursitis

What to say

The small cushion in front of your kneecap is swollen, often after kneeling or a direct bump.

Avoid kneeling on it and use padding when you return to that activity. We must check for infection before treating this as simple irritation.

Clinical reference

Before explaining

Assess skin breaks, heat, fever and knee motion; distinguish joint effusion.

Warning signs

Increasing redness, warmth, drainage or fever needs same-day assessment.

Follow-up

Recheck persistent swelling and ability to kneel safely.

Sources

Checked September 24, 2026.

Rheumatoid arthritis

What to say

Persistent swelling and stiffness in several joints can mean the immune system is inflaming the joints. We need to assess this early because untreated inflammation can damage them.

I’ll arrange the appropriate tests and rheumatology assessment. Pain relief can help meanwhile, but disease-controlling treatment is what protects the joints.

Clinical reference

Before explaining

Document synovitis, distribution, morning stiffness and systemic features; normal inflammatory markers or antibodies do not exclude disease.

Warning signs

A hot single joint, fever or rapidly worsening function needs urgent reassessment.

Follow-up

Arrange timely rheumatology review; confirm referral completion and interim symptom control.

Sources

Checked September 24, 2026.

Rotator cuff tear

What to say

A rotator cuff tear means one of the shoulder tendons is partly or fully torn. Some tears improve with rehabilitation. Others need a surgical opinion.

The timing of injury, your strength and your goals guide the next step. We’ll arrange imaging or referral when it changes treatment and give you an activity plan meanwhile.

Clinical reference

Before explaining

Distinguish traumatic from degenerative tears; document objective weakness and functional loss.

Warning signs

Sudden inability to lift the arm after injury needs prompt assessment and referral.

Follow-up

Track strength and function; expedite specialist review for an acute traumatic tear.

Sources

Checked September 24, 2026.

Rotator cuff tendinopathy

What to say

The tendons that help lift and steady your shoulder appear irritated. Reaching overhead or lying on that side may hurt.

Reduce the movements that repeatedly flare it while keeping the shoulder gently moving. Progressive shoulder exercises are central to recovery. We can add pain relief and consider other options if progress stalls.

Clinical reference

Before explaining

Assess active/passive motion, strength, neck symptoms and injury; distinguish significant tear.

Warning signs

New marked weakness after injury, deformity or a hot joint needs urgent review.

Follow-up

Review movement and strength after the rehabilitation trial.

Sources

Checked September 24, 2026.

Sciatica

What to say

Sciatica means a nerve from the lower back is irritated, causing pain down the leg. Many episodes improve over time.

Keep moving within your limits and avoid prolonged bed rest. We’ll choose symptom relief and a rehabilitation plan. Scans are useful when their result would change treatment.

Clinical reference

Before explaining

Assess motor function, sensation, reflexes and serious spinal causes.

Warning signs

New urinary retention, saddle numbness, loss of bowel control or severe/progressive leg weakness needs emergency assessment.

Follow-up

Review strength and function; refer persistent disabling symptoms or deficits.

Sources

Checked September 24, 2026.

Sjögren’s disease

What to say

Sjögren’s disease is an autoimmune condition in which the immune system attacks the glands that make tears and saliva. It causes dry eyes and dry mouth, and often tiredness and joint pain.

Eye drops, sips of water, sugar-free gum and, if needed, saliva-boosting medicines ease dryness. See your dentist regularly, because cavities are more common. Tell us about glands or lymph nodes that stay swollen, new cough or breathlessness, or numbness.

Clinical reference

Before explaining

Check ANA, anti-SSA/Ro and SSB/La, and RF; arrange an eye exam; consider salivary gland biopsy if antibodies are negative.

Warning signs

Persistent salivary gland swelling, lymphadenopathy, neuropathy, or lung or kidney symptoms need rheumatology review; lymphoma risk is higher but low.

Follow-up

Refer to rheumatology; arrange regular dental and eye care; treat dryness stepwise, from water, gum and fluoride to pilocarpine or cevimeline.

Sources

Checked October 20, 2026.

Spine compression fracture

What to say

A compression fracture is a small collapse of one spine bone, often because the bone is thin. The pain usually eases over weeks to a few months.

We’ll choose safe pain relief, keep you moving, and check your bone strength to prevent the next fracture. Go to the emergency department for new leg weakness or numbness, or trouble controlling urine or stool. Get same-day care for fever or worsening pain.

Clinical reference

Before explaining

Exclude cord or cauda equina compromise, cancer and infection; obtain AP/lateral spine films, then DXA and secondary osteoporosis workup.

Warning signs

New leg weakness, numbness or bladder/bowel change is an emergency; fever, night pain or cancer history needs urgent imaging.

Follow-up

Reassess at about 2 weeks and start rehabilitation; treat osteoporosis; vertebral augmentation is controversial; consider it only if pain stays disabling despite conservative care.

Sources

Checked October 15, 2026.

Stress fracture

What to say

A stress fracture is a tiny crack in a bone from repeated impact. Pain builds with activity and eases with rest. Early X-rays can look normal, so you may need an MRI.

Healing often takes 1 to 3 months of rest from impact, sometimes with a boot. We’ll review your nutrition, vitamin D and bone health. For hip or groin pain, get same-day care and keep weight off that leg.

Clinical reference

Before explaining

Assess training load, energy availability, menstrual history and vitamin D; MRI if films are negative; identify high-risk sites.

Warning signs

High-risk sites (femoral neck, navicular, fifth metatarsal) need specialist input; hip or groin pain needs urgent imaging, no weight bearing.

Follow-up

Reassess every 2–3 weeks; return to impact gradually once pain-free; correct energy deficit and consider DXA if risk factors.

Sources

Checked October 15, 2026.

Tailbone pain

What to say

Tailbone pain, or coccydynia, often follows a fall, childbirth or prolonged sitting, and sometimes has no clear cause. It usually improves over weeks but can last longer.

Use a coccyx cushion, avoid long sitting, and try ibuprofen if it’s safe for you. Physical therapy or an injection can help if pain lingers. Get same-day care for fever, redness or swelling near the tailbone, numbness, or bowel or bladder changes.

Clinical reference

Before explaining

Ask about trauma and sitting; examine for pilonidal disease; consider imaging if pain is severe, persistent or has red flags.

Warning signs

Fever, swelling or drainage at the gluteal cleft, numbness, or bowel or bladder change needs same-day evaluation.

Follow-up

Reassess after a few weeks; if still limiting, add pelvic floor physical therapy or injection and consider imaging.

Sources

Checked October 15, 2026.

Tennis elbow

What to say

The tendon on the outside of your elbow is irritated by gripping or lifting. You don’t need to play tennis to develop this.

Temporarily change the tasks that provoke it, then rebuild strength gradually. A therapist can help with exercises and work adjustments. A support may ease some activities.

Clinical reference

Before explaining

Check location, resisted wrist extension, neck symptoms and nerve findings.

Warning signs

A hot swollen elbow, major injury or new hand weakness needs prompt assessment.

Follow-up

Review if not improving with activity changes and rehabilitation.

Sources

Checked September 24, 2026.

Trigger finger

What to say

The tendon moving this finger is catching as it passes through a tight tunnel. That causes the clicking or locking.

We can reduce provoking gripping, try a splint, or discuss a steroid injection. A finger that remains stuck or keeps interfering with daily tasks may need a hand specialist.

Clinical reference

Before explaining

Confirm triggering; assess fixed contracture, diabetes and other hand pathology.

Warning signs

A red, very swollen finger or severe pain with movement needs urgent review.

Follow-up

Review locking frequency and function; refer if fixed or persistent.

Sources

Checked September 24, 2026.

Wrist injury and possible scaphoid fracture

What to say

A fall on an outstretched hand can break the scaphoid, a wrist bone near the thumb. X-rays can miss it early, and it can heal poorly, so we treat thumb-side wrist tenderness as a fracture.

You’ll wear a thumb splint, and we’ll repeat the X-ray or get an MRI in 1 to 2 weeks. Go to the emergency department for a crooked wrist, numb fingers or an open wound.

Clinical reference

Before explaining

Snuffbox or thumb-compression tenderness: splint in thumb spica even if films are negative; examine for distal radius fracture, neurovascular injury.

Warning signs

Deformity, numbness, open wound or pale, cold hand needs emergency care; persistent snuffbox pain with normal films suggests occult fracture.

Follow-up

Re-examine and repeat films, or get MRI/CT, at 1–2 weeks; refer displaced, proximal-pole or non-healing fractures to hand surgery.

Sources

Checked October 15, 2026.

Urinary & sexual health

Acute bacterial prostatitis

What to say

A bacterial infection in the prostate can cause painful urination, pelvic pain and fever. It needs antibiotics and a check for complications.

We’ll use urine testing to guide treatment and arrange close follow-up. If you can’t urinate, can’t keep medicines down or become very unwell, seek urgent care.

Clinical reference

Before explaining

Assess sepsis, retention, urine culture and STI risk; avoid vigorous prostate massage.

Warning signs

Confusion, severe weakness or systemic deterioration requires emergency care; retention requires urgent drainage assessment.

Follow-up

Review within 48 hours if not improving; tailor antibiotics to culture and response.

Sources

Checked September 24, 2026.

Bladder pain syndrome

What to say

Bladder pain syndrome can cause pain as the bladder fills and frequent trips to the toilet, even when cultures don’t show an infection.

We’ll rule out other causes and look for your individual triggers. Treatment may combine bladder habits, pelvic-floor therapy, pain relief and specialist care. Improvement can take several steps.

Clinical reference

Before explaining

Assess cultures, hematuria, pelvic-floor function and alternative urinary/gynecologic causes.

Warning signs

Visible blood, fever, retention or a major change in symptoms requires reassessment.

Follow-up

Track pain and frequency; review one treatment change at a time.

Sources

Checked September 24, 2026.

Blood in the urine

What to say

Blood in the urine needs an explanation, even if it happens once or causes no pain. Infection and stones are possible, but we also need to consider other urinary-tract problems.

We’ll confirm where the blood is coming from and arrange the appropriate urine tests, imaging or urology evaluation. Blood thinners don’t remove the need to investigate.

Clinical reference

Before explaining

Distinguish visible/microscopic hematuria and menstrual contamination; assess infection and malignancy risk.

Warning signs

Clots with inability to urinate, heavy bleeding, fever or severe flank pain needs urgent care.

Follow-up

Track results to completion; confirm resolution after infection and arrange indicated referral.

Sources

Checked September 24, 2026.

Chlamydia and gonorrhea

What to say

These infections are treatable and can be present without symptoms. Testing should match the body sites exposed, not just a urine sample.

We’ll give the right antibiotic, arrange partner treatment and explain exactly when sex is safe again. Retesting matters because getting infected again is common. Treatment doesn’t create immunity.

Clinical reference

  • Avoid sex for seven days after single-dose treatment or until a seven-day course is completed, symptoms have resolved, and partners have been treated. Pharyngeal gonorrhea needs a test of cure at 7–14 days; pregnancy changes chlamydia treatment and test-of-cure requirements.

Before explaining

Assess pregnancy, exposure sites, allergies, PID/epididymitis and HIV/syphilis testing; use organism-specific treatment.

Warning signs

Pelvic pain, fever, testicular pain or joint/eye symptoms needs prompt assessment.

Follow-up

Retest around three months; arrange organism/site-specific test of cure when indicated.

Sources

Checked September 24, 2026.

Chronic pelvic pain syndrome

What to say

Persistent pelvic or prostate-area pain doesn’t always mean an ongoing bacterial infection. Muscles, nerves and urinary symptoms can all contribute.

We’ll look for treatable causes and build a plan that may include pelvic-floor therapy, symptom medicines and urology support. Repeated antibiotics aren’t automatically helpful when infection hasn’t been found.

Clinical reference

Before explaining

Assess urine testing, STI risk, pelvic-floor tenderness and other pelvic pathology.

Warning signs

Fever, inability to urinate, visible blood or sudden testicular pain needs urgent reassessment.

Follow-up

Track pain, urination, sexual function and response to each treatment.

Sources

Checked September 24, 2026.

Enlarged prostate

What to say

As the prostate enlarges, it can narrow the urine channel and cause a slow stream, hesitancy or frequent nighttime trips. Similar symptoms can have other causes.

We’ll check how well your bladder empties and how much symptoms bother you. Changes in habits, medicines or a procedure may help, depending on the findings.

Clinical reference

Before explaining

Assess urinalysis, retention, medicines and neurologic signs; discuss PSA when appropriate rather than assuming benign disease.

Warning signs

Inability to urinate needs urgent care; fever, visible blood or severe pain needs prompt assessment.

Follow-up

Review symptom score, emptying and treatment side effects.

Sources

Checked September 24, 2026.

Epididymitis

What to say

Epididymitis is swelling of the tube behind the testicle, usually from infection. Pain builds over hours to days, sometimes with fever or burning when you pee.

We’ll test for infection and STIs and start antibiotics for the likely cause. Rest, snug support, ice and an anti-inflammatory can help. Avoid sex until you and any partners are treated. Sudden, severe testicle pain is an emergency, so go to the emergency department. Call us if you’re no better in 3 days.

Clinical reference

Before explaining

Exclude torsion first. Test urine and urethral NAAT for gonorrhea and chlamydia; choose antibiotics by sexual practices, age and culture (CDC 2021).

Warning signs

Sudden severe pain, high fever, spreading redness or a hard swollen testicle needs emergency assessment (torsion, abscess, infarction).

Follow-up

Reassess at 72 hours if no better; swelling persisting after treatment needs imaging and other diagnoses. If STI, treat partners from the past 60 days.

Sources

Checked October 15, 2026.

Erectile dysfunction

What to say

Difficulty getting or keeping an erection is common and treatable. Circulation, medicines, hormones, stress and relationship factors can all contribute.

We’ll discuss what has changed and check relevant health risks. Treatment may include addressing those causes, counseling or medicine. Pills such as sildenafil are unsafe with nitrates such as nitroglycerin or poppers.

Clinical reference

Before explaining

Review cardiovascular fitness for sex, medicines including nitrates/riociguat, diabetes and indicated hormone testing.

Warning signs

An erection lasting four hours needs emergency care; chest pain during sex needs urgent assessment.

Follow-up

Review treatment effectiveness, tolerability and underlying health risks.

Sources

Checked September 24, 2026.

Functional urinary incontinence

What to say

Leakage can happen because getting to or using the toilet is difficult, even when the bladder itself works reasonably well.

We can adjust toilet access, clothing, mobility support and reminders around your routine. Pads can protect clothing, but we should also address the obstacles causing the accidents.

Clinical reference

Before explaining

Assess mobility, cognition, medications, environment and coexisting bladder disease.

Warning signs

Sudden confusion, weakness, pain or an abrupt change in continence needs assessment.

Follow-up

Review accidents, skin health, dignity and caregiver burden after practical changes.

Sources

Checked September 24, 2026.

Genital herpes

What to say

Herpes is a common virus that can cause genital sores and later outbreaks. A new outbreak can’t tell us exactly when the infection was acquired.

Antiviral treatment can shorten outbreaks, and daily treatment may reduce recurrences and transmission. Avoid sexual contact during warning symptoms or sores. Condoms reduce but don’t eliminate risk.

Clinical reference

Before explaining

Swab active lesions when appropriate; assess pregnancy, immune status and other STI testing.

Warning signs

Inability to urinate, severe systemic illness, eye symptoms or pregnancy with new lesions needs urgent advice.

Follow-up

Review healing and discuss episodic versus suppressive treatment.

Sources

Checked September 24, 2026.

Genital warts

What to say

These growths are caused by HPV. Treatment removes visible warts, but they can recur and the virus can spread without visible growths.

We can discuss a suitable prescription or office treatment. Don’t use ordinary pharmacy wart remover on genital skin. Continue recommended cervical screening and discuss HPV vaccination if eligible.

Clinical reference

Before explaining

Confirm diagnosis; biopsy atypical, pigmented, bleeding or treatment-resistant lesions. Consider pregnancy and immune status.

Warning signs

Rapid growth, ulceration or unexplained bleeding requires reassessment.

Follow-up

Review treatment response, skin irritation and recurrence.

Sources

Checked September 24, 2026.

HIV prevention (PrEP)

What to say

PrEP is medicine that greatly lowers your chance of getting HIV: a daily pill, or a shot every 2 or 6 months. You’ll need HIV tests before starting and regularly while on it.

Most insurance covers PrEP at no cost to you. Condoms add protection against other STIs. If you’re exposed to HIV while not on PrEP, call us the same day: emergency PEP must start within 72 hours.

Clinical reference

Before explaining

Confirm HIV-negative (Ag/Ab; add RNA after recent exposure) before starting. Oral PrEP: check eCrCl and hepatitis B. F/TAF isn’t for receptive vaginal sex.

Warning signs

Flu-like illness or rash after a recent exposure may be acute HIV: test HIV RNA before starting or continuing PrEP.

Follow-up

Oral PrEP: HIV testing every 3 months, STIs at least every 6 months, eCrCl yearly (6-monthly if ≥50 or baseline <90). 2-1-1 dosing is off-label. Offer doxy-PEP when eligible.

Sources

Checked October 15, 2026.

Kidney infection (pyelonephritis)

What to say

A kidney infection usually starts in the bladder and travels up to a kidney. It often causes fever, back or side pain and nausea, and needs antibiotics promptly.

We’ll check a urine culture and adjust the antibiotic if needed. Take every dose, and call us if you’re not better in 2–3 days. Go to the emergency department if you can’t keep pills or fluids down, feel faint or confused, or have shaking chills.

Clinical reference

Before explaining

Urine culture before antibiotics; check pregnancy. Ask about stones, immunosuppression, recent urologic procedures, prior resistant isolates and recent fluoroquinolones.

Warning signs

Hypotension, rigors, confusion or persistent vomiting suggests sepsis or failed oral therapy; send to the ED.

Follow-up

Check in at 48–72 hours; tailor antibiotics to culture. If not improving, image (CT or ultrasound) for obstruction or abscess.

Sources

Checked October 15, 2026.

Kidney stones

What to say

A stone moving through the urine tube can cause intense pain that comes in waves, sometimes with blood in the urine.

We’ll check its likely size and location, control pain and decide whether it can pass safely or needs a procedure. If you collect a passed stone, analysis can help prevent another.

Clinical reference

Before explaining

Assess infection, obstruction, renal function, pregnancy and solitary kidney; select imaging appropriately.

Warning signs

Fever or chills with suspected stone, inability to urinate or uncontrolled vomiting/pain needs emergency assessment.

Follow-up

Confirm passage or relief of obstruction; discuss prevention after the acute episode.

Sources

Checked September 24, 2026.

Low sexual desire

What to say

Sexual desire varies. It becomes a health concern when the change bothers you, and there’s no single amount of desire everyone should have.

We can look at pain, stress, sleep, relationships, medicines and hormonal changes. The plan should reflect what you want. Hormone treatment is only appropriate for specific assessed situations.

Clinical reference

Before explaining

Clarify distress and goals privately; assess mood, coercion, medications, pain and endocrine clues.

Warning signs

New severe depression, safety concerns or genital/pelvic pain needs timely attention.

Follow-up

Review the contributors identified and whether changes improve wellbeing.

Sources

Checked September 24, 2026.

Low testosterone

What to say

Testosterone varies through the day and with age, so a single low result isn’t a diagnosis. We’ll confirm with 2 early-morning fasting tests and look for causes like excess weight, sleep apnea or medicines.

Treatment can modestly improve sex drive; effects on energy and mood are less certain. It can stop sperm production, so tell us if you may want children. We’d check your blood count and blood pressure, and often a prostate (PSA) test.

Clinical reference

Before explaining

Symptoms plus 2 low morning fasting total testosterone levels; then LH/FSH (prolactin if not elevated). Defer for near-term fertility plans, elevated hematocrit, untreated severe OSA.

Warning signs

Hematocrit >54%: hold and evaluate. Rising BP (2025 FDA class warning), edema, worsening sleep apnea, VTE, urinary symptoms or PSA rise.

Follow-up

Recheck symptoms, level, hematocrit and BP at 3–6 months, then yearly. June 2026: FDA proposed label changes (age-related limitation, prostate warnings); check current labeling.

Sources

Checked October 15, 2026.

Mixed urinary incontinence

What to say

You describe both leakage with coughing or activity and leakage after a sudden urge. Those are two different mechanisms, so one treatment may not address both.

We’ll work on pelvic-floor strength and bladder habits, starting with the symptom that bothers you most. A diary helps us see which part is improving.

Clinical reference

Before explaining

Confirm both patterns and assess reversible causes; consider specialist evaluation if uncertain.

Warning signs

New pain, blood or difficulty emptying changes the plan.

Follow-up

Review each leakage pattern separately after treatment.

Sources

Checked September 24, 2026.

Mpox

What to say

Mpox is a viral infection that causes sores, often on the genitals, anus or mouth, sometimes with fever and swollen glands. It spreads mainly through close skin-to-skin contact, including sex.

We’ll test a sore. Stay home, avoid sex and close contact, and keep sores covered until the rash has fully healed. Tell recent partners so they can get vaccinated quickly. Get same-day care for sores near your eyes, severe pain, trouble swallowing, or rectal pain or bleeding.

Clinical reference

Before explaining

Swab lesions for mpox PCR; offer HIV/STI testing. Report to public health; clade I community spread in California since October 2025.

Warning signs

Eye, mouth, rectal or extensive lesions, severe pain, or advanced HIV/immunosuppression: urgent review and public health input on antivirals.

Follow-up

Isolate until the rash heals. JYNNEOS as soon as possible after exposure; 2-dose series for people at risk; boosters not recommended.

Sources

Checked October 15, 2026.

New HIV diagnosis

What to say

This result can bring up a lot of feelings. HIV is treatable, and effective treatment allows people to live long, healthy lives.

We’ll confirm the diagnosis as needed and connect you promptly with treatment and support. Taking treatment and maintaining an undetectable viral load prevents sexual transmission. We’ll verify that with blood tests.

Clinical reference

Before explaining

Distinguish screening from confirmed diagnosis; arrange viral load, CD4, resistance and coinfection evaluation without unnecessary treatment delay.

Warning signs

Severe headache, trouble breathing, confusion or serious systemic illness needs urgent evaluation.

Follow-up

Make a concrete early care appointment and track treatment access and viral suppression.

Sources

Checked September 24, 2026.

Overflow urinary incontinence

What to say

Sometimes leakage happens because the bladder isn’t emptying and becomes too full. Dribbling doesn’t necessarily mean the bladder is empty.

We need to measure the urine left after you go and look for blockage, nerve problems or medicine effects. Treatment focuses on safe emptying before simply trying to reduce urgency.

Clinical reference

Before explaining

Measure postvoid residual when indicated; assess renal effects, constipation, obstruction and neurologic causes.

Warning signs

Painful inability to urinate or new saddle numbness/leg weakness needs emergency assessment.

Follow-up

Arrange prompt evaluation and a documented emptying plan.

Sources

Checked September 24, 2026.

Peyronie disease

What to say

Scar tissue in the penis can cause a bend or painful erections. The amount of pain, change in shape and effect on sex guide treatment.

We can arrange a urology assessment if the bend is new, worsening or interfering with sex. Treatment options depend on whether the condition is still changing or has become stable.

Clinical reference

Before explaining

Document onset, curvature, plaque, pain, erectile function and distress.

Warning signs

A sudden snap with bruising after an injury needs emergency assessment for penile fracture.

Follow-up

Monitor change and confirm urology review when indicated.

Sources

Checked September 24, 2026.

Possible HIV exposure

What to say

PEP is medicine that can prevent HIV after an exposure. It works best started within 24 hours and must start within 72 hours, so don’t wait for test results.

It’s 28 days of daily pills, plus HIV tests now, at 4–6 weeks and at 12 weeks. If we’re closed, go to urgent care, an emergency department or a pharmacy that offers PEP. After sexual assault, go to an emergency department for PEP and a forensic exam.

Clinical reference

Before explaining

Assess exposure type, timing (≤72 hours) and source status; start before baseline results return. Work exposures follow occupational PEP guidance.

Warning signs

Fever, rash or swollen glands may signal acute HIV; test with NAT. If HBsAg positive, stopping tenofovir can flare hepatitis B.

Follow-up

Baseline HIV, HBV, creatinine, ALT and pregnancy tests; HIV Ag/Ab plus NAT at 4–6 and 12 weeks. Offer PrEP for ongoing risk.

Sources

Checked October 15, 2026.

Premature ejaculation

What to say

Ejaculating sooner than you want can cause distress, and it’s something we can work on. The pattern and whether it’s new help guide treatment.

Behavioral techniques, counseling and sometimes medication can help. We’ll also address erection difficulties or relationship concerns if they’re part of the picture.

Clinical reference

Before explaining

Distinguish lifelong/acquired symptoms, erectile dysfunction, medication effects and urinary/pelvic symptoms.

Warning signs

New pain, blood in semen or urinary symptoms should be evaluated separately.

Follow-up

Review control, distress, partner concerns if invited and treatment adverse effects.

Sources

Checked September 24, 2026.

Recurrent urinary tract infection

What to say

Repeated bladder infections deserve a plan to confirm the cause and reduce recurrences. Burning isn’t always caused by bacteria.

We’ll review urine-culture results and possible triggers. Depending on your situation, prevention may include vaginal estrogen after menopause or a carefully chosen preventive medicine.

Clinical reference

Before explaining

Document symptomatic culture-supported episodes; assess retention, stones, pregnancy and alternative diagnoses.

Warning signs

Fever, flank pain, vomiting or feeling very ill needs urgent assessment for kidney infection.

Follow-up

Review each breakthrough episode and the benefit/harms of prevention.

Sources

Checked September 24, 2026.

Stress urinary incontinence

What to say

Leaking when you cough, laugh or exercise often means the support around the urine outlet isn’t holding firmly enough under pressure.

Pelvic-floor training with the right technique is a first step. We can arrange therapy and discuss other options if leakage keeps affecting your life. You don’t have to simply live with it.

Clinical reference

Before explaining

Confirm exertional pattern; assess urinalysis, pelvic/prostate history, prolapse and ability to contract pelvic floor.

Warning signs

Blood in urine, painful urination or difficulty emptying needs reassessment.

Follow-up

Review after a supervised pelvic-floor training course, commonly at least three months.

Sources

Checked September 24, 2026.

Syphilis

What to say

Syphilis is a bacterial infection that can affect different parts of the body and may have long symptom-free periods. It’s curable with the right treatment.

The treatment depends on the stage and any nerve, eye or ear symptoms. We’ll arrange partner evaluation and repeat blood tests to check the response.

Clinical reference

Before explaining

Confirm serology/stage, previous treatment, pregnancy and neurologic/ocular/otic symptoms; test for HIV.

Warning signs

Vision change, hearing change or neurologic symptoms needs urgent specialist assessment.

Follow-up

Set stage-specific serologic follow-up and confirm partner management.

Sources

Checked September 24, 2026.

Testicular pain or swelling

What to say

Testicular pain has several causes. A sudden severe pain can mean the testicle has twisted and lost its blood supply, which is an emergency.

If the pain started suddenly, especially with nausea or swelling, go to the emergency department now. A persistent lump or less severe swelling still needs an examination and sometimes an ultrasound.

Clinical reference

Before explaining

Establish onset and torsion risk immediately; do not delay emergency referral for routine testing.

Warning signs

Sudden severe pain requires immediate emergency assessment, even if it later eases.

Follow-up

Confirm evaluation of any persistent lump, swelling or recurrent pain.

Sources

Checked September 24, 2026.

Trichomoniasis

What to say

Trichomoniasis, or trich, is a common sexually transmitted infection caused by a tiny parasite. It can cause discharge, itching or burning, but many people have no symptoms.

It’s treated with a medicine called metronidazole, and your partners need treatment too. Avoid sex until you and your partners have finished treatment and any symptoms are gone. We’ll test for other STIs and, for women, repeat the trich test in about 3 months.

Clinical reference

Before explaining

Test for chlamydia, gonorrhea, syphilis and HIV. CDC regimen: women metronidazole 500 mg twice daily × 7 days; men 2 g once.

Warning signs

Persistent or recurrent symptoms need retesting and review of adherence and partner treatment. Pregnancy needs a separate plan.

Follow-up

Retest sexually active women about 3 months after treatment (or at a visit within 12 months); no routine retest for men.

Sources

Checked October 15, 2026.

Uncomplicated bladder infection

What to say

Your symptoms fit an infection in the bladder. The antibiotic we’ve chosen should start easing the burning and urgency over the next couple of days. Take it for the exact number of days on the prescription.

If we sent a culture, I’ll review it and let you know whether to continue or change treatment. Call the same day for fever, shaking chills, pain in your side or back, or vomiting. Those can mean the infection needs a different treatment. If you’re getting very sick or can’t keep fluids down, go to the emergency department. If you haven’t begun improving within about 48 hours, contact us rather than taking leftover antibiotics or extending the course yourself.

Clinical reference

  • Examples: nitrofurantoin monohydrate/macrocrystals 100 mg BID ×5 days; or TMP/SMX DS 160/800 mg BID ×3 days when susceptibility/local resistance supports it.
  • Use the uncomplicated-woman pathway only when it fits. Culture when indicated by atypical/recurrent symptoms, complicated features, resistance concern or treatment failure.
  • TMP/SMX for uncomplicated cystitis requires a susceptible isolate or local resistance <20%; check pregnancy, renal function and interactions.

Before explaining

Check pregnancy, fever/flank pain, vaginal/STI symptoms, renal function, allergies and prior cultures. Prostate involvement, pyelonephritis or urinary abnormalities changes the plan.

Warning signs

Possible infected obstruction, sepsis or inability to hydrate requires emergency assessment. Nitrofurantoin does not treat renal parenchymal infection.

Follow-up

Review any culture through completion. Reassess lack of improvement within 48 hours, and sooner for deterioration; no automatic test-of-cure in a resolved routine uncomplicated case.

Sources

Checked September 20, 2026.

Urgency incontinence and overactive bladder

What to say

A sudden hard-to-control urge, sometimes followed by leakage, can happen when the bladder signals too urgently.

A bladder diary can show the pattern. Bladder training, adjusting caffeine and fluid timing, and sometimes medicine can help. We’ll choose treatment around your other health conditions and side-effect risks.

Clinical reference

Before explaining

Exclude infection, hematuria and retention; review constipation, drugs and cognitive/anticholinergic risks.

Warning signs

Inability to empty, visible blood or new neurologic symptoms needs prompt review.

Follow-up

Review diary, urgency and tolerability after the agreed treatment trial.

Sources

Checked September 24, 2026.

Urinary retention

What to say

Your bladder may not be emptying properly. A sudden inability to pass urine can injure the bladder and kidneys and needs urgent treatment.

If you can’t urinate now, we need urgent assessment and may need to drain the bladder with a catheter. Then we’ll investigate the cause and make a plan for safe emptying.

Clinical reference

Before explaining

Assess onset, residual volume, renal function, medications, obstruction and neurologic findings.

Warning signs

Acute inability to urinate, severe lower abdominal pain or new saddle numbness requires emergency assessment.

Follow-up

Document catheter/voiding-trial follow-up and evaluation of the underlying cause.

Sources

Checked September 24, 2026.

Vasectomy

What to say

A vasectomy is a brief office procedure that blocks the tubes carrying sperm. Treat it as permanent. It doesn’t change erections or ejaculation, and it doesn’t work right away.

Keep using other birth control until a semen test, at least 8 weeks later, shows no sperm or only rare non-moving sperm. Soreness, swelling and bruising can last up to 2 weeks; ice and snug support help. It doesn’t protect against STIs. Call us for fever, pus, or growing, painful swelling.

Clinical reference

Before explaining

Counsel permanence, delayed effect and risks (hematoma or infection 1–2%, chronic pain 1–2%). Examine the scrotum; review anticoagulants and bleeding history.

Warning signs

Expanding hematoma, fever, drainage or severe pain needs same-day review; pain lasting weeks suggests chronic scrotal pain.

Follow-up

Semen analysis from 8 weeks: clearance needs azoospermia or ≤100,000 non-motile sperm/mL. Persistent motile sperm at 6 months: offer repeat vasectomy.

Sources

Checked October 15, 2026.

Waking at night to urinate

What to say

Waking at night to urinate becomes more common with age. Causes include evening drinks, water pills, leg swelling, diabetes, heart failure, sleep apnea, and bladder or prostate problems.

Keep a record for a few days of what you drink, and when and how much you urinate. Cutting back on evening fluids, caffeine and alcohol can help, and we may move a water pill earlier in the day. A night-light helps prevent falls.

Clinical reference

Before explaining

Use a frequency–volume chart to separate nocturnal polyuria from bladder causes. Review diuretic timing, edema, glucose, heart failure and sleep apnea.

Warning signs

Polyuria with thirst or weight loss, hematuria, urinary retention, or edema with breathlessness needs prompt evaluation.

Follow-up

Review the chart and treat causes. Desmopressin only for confirmed nocturnal polyuria, with sodium monitoring; hyponatremia risk rises with age.

Sources

Checked October 15, 2026.

Gynecology & breast health

Bacterial vaginosis

What to say

Bacterial vaginosis is a change in the balance of vaginal bacteria that can cause odor and discharge. It doesn’t mean poor hygiene.

An antibiotic can help symptomatic infection. Avoid douching, which can disturb the balance further. If it recurs, we can reassess and discuss a prevention plan.

Clinical reference

Before explaining

Confirm diagnosis; assess pregnancy, STI risk and other causes of discharge.

Warning signs

Pelvic pain, fever or bleeding needs evaluation for another problem.

Follow-up

Reassess recurrence and use current guidance when discussing partner treatment.

Sources

Checked September 24, 2026.

Bleeding after menopause

What to say

Any vaginal bleeding after menopause, even a small amount once, should be checked. Thinning tissues can cause it, but we need to exclude changes in the uterine lining, including cancer.

We’ll arrange an examination and the appropriate ultrasound or tissue sample. If bleeding recurs after reassuring tests, tell us so we can reassess.

Clinical reference

Before explaining

Confirm bleeding source, menopausal status, HRT/tamoxifen use and risk factors; arrange prompt evaluation.

Warning signs

Heavy bleeding with dizziness or fainting needs emergency care.

Follow-up

Track testing to completion; recurrent or persistent bleeding requires renewed evaluation.

Sources

Checked September 24, 2026.

Breast lump

What to say

Many breast lumps are benign, but a new lump needs assessment. Feeling it alone can’t reliably tell us what it is.

We’ll arrange the appropriate breast examination and diagnostic imaging, and sometimes a biopsy. A recent normal screening mammogram doesn’t replace evaluation of a new lump.

Clinical reference

Before explaining

Assess location, duration, skin/nipple changes, nodes and relevant history; use diagnostic pathway.

Warning signs

Rapid redness with fever needs same-day review; new dimpling, bloody discharge or a persistent lump needs prompt workup.

Follow-up

Track imaging and any biopsy through to a clear result and plan.

Sources

Checked September 24, 2026.

Breast pain

What to say

Breast pain can follow hormone changes, chest-wall strain or other benign causes. Pain alone is less likely to represent cancer, but we still assess its pattern.

A supportive bra and suitable pain relief may help. Persistent pain in one spot, a lump or a skin or nipple change may need imaging or breast-clinic review.

Clinical reference

Before explaining

Assess focality, cycle relation, pregnancy/lactation, medicines and breast/chest-wall examination.

Warning signs

A red hot breast with fever needs same-day assessment; a new lump or bloody discharge needs prompt evaluation.

Follow-up

Review persistent focal pain and confirm any ordered imaging.

Sources

Checked September 24, 2026.

Choosing contraception

What to say

Let’s match birth control to your health and goals. Implants and IUDs work best and last years. The shot, pill, patch and ring work well if used on time. Only condoms also prevent STIs.

Estrogen isn’t safe for smokers 35 or older or people with migraine aura or past blood clots. Most methods can start today, sometimes with condoms for a week. After unprotected sex, emergency pills or a copper IUD can help; act fast.

Clinical reference

Before explaining

Apply US MEC 2024: avoid estrogen with migraine with aura, age ≥35 and smoking, BP ≥140/90, prior VTE or thrombophilia.

Warning signs

On estrogen: chest pain, breathlessness, leg swelling, severe headache or vision loss. With an IUD: pelvic pain, fever or a positive pregnancy test.

Follow-up

Quick-start if reasonably certain not pregnant, with backup per SPR (usually 7 days; none for copper IUD). Opill and levonorgestrel EC are OTC.

Sources

Checked October 15, 2026.

Endometriosis

What to say

Endometriosis is tissue similar to the uterine lining growing outside the uterus. It can cause period pain, pain with sex or bowel symptoms.

A normal ultrasound doesn’t rule it out. We can discuss pain treatment and hormonal options while arranging gynecology assessment when needed, especially if symptoms persist or fertility is a concern.

Clinical reference

Before explaining

Assess pregnancy, infection, symptom pattern, function and fertility goals.

Warning signs

Sudden severe pain, fainting, fever or possible ectopic pregnancy requires urgent care.

Follow-up

Review symptom control and access to gynecology evaluation.

Sources

Checked September 24, 2026.

Heavy menstrual bleeding

What to say

Periods are too heavy when they disrupt your life or cause problems such as anemia. We should look for the cause rather than expect you to tolerate them.

We’ll check for anemia and choose treatment around your health and pregnancy plans. Options can include medicines, an intrauterine device or further assessment for structural causes.

Clinical reference

Before explaining

Assess pregnancy possibility, bleeding severity, medications, anemia and indications for ultrasound/endometrial sampling.

Warning signs

Very heavy ongoing bleeding with faintness, chest pain or breathlessness needs emergency care.

Follow-up

Review bleeding and blood count/iron response; track indicated investigations.

Sources

Checked September 24, 2026.

Hereditary cancer risk

What to say

Some cancers run in families through inherited gene changes, like BRCA or Lynch syndrome. Clues include several relatives with the same cancer, cancer at young ages, male breast cancer, or Ashkenazi Jewish ancestry.

A genetic counselor can help you decide whether testing makes sense. Results can change your screening and prevention. A federal law, GINA, bars health insurers and most employers from using genetic results, but life, disability and long-term care insurers aren’t covered.

Clinical reference

Before explaining

Take a family history on both sides. Use a validated brief risk tool, refer positives for genetic counseling, and test an affected relative first if possible.

Warning signs

Negative results in unaffected relatives are uninformative. Variants of uncertain significance should not change management; keep risk-based screening.

Follow-up

Confirm the counseling visit and insurance coverage; update screening (MRI, colonoscopy) after results; encourage sharing with relatives.

Sources

Checked October 15, 2026.

Irregular or absent periods

What to say

Changes in periods can come from pregnancy, stress, nutrition, exercise, medicines or hormone conditions. The pattern helps us decide what to test.

If pregnancy is possible, we’ll test first. Then we can assess other causes and discuss whether treatment is needed for symptoms, fertility or protection of the uterine lining.

Clinical reference

Before explaining

Assess pregnancy, weight/nutrition changes, prolactin/thyroid clues and prolonged anovulation.

Warning signs

Possible pregnancy with one-sided pain, shoulder pain or fainting needs emergency assessment.

Follow-up

Arrange results review and follow-up if periods remain absent or infrequent.

Sources

Checked September 24, 2026.

Menopause-related vaginal symptoms

What to say

Lower estrogen after menopause can make the vaginal and nearby urinary tissues drier and more sensitive. That can cause burning, discomfort with sex and some urinary symptoms. There are treatments, and you don’t have to simply tolerate it.

We can start with a vaginal moisturizer and lubricant for sex, or discuss low-dose vaginal estrogen when appropriate. That treatment works mostly in the local tissues and is different from estrogen pills or patches used for hot flashes. It usually takes several weeks to judge the benefit, and symptoms can return when treatment stops. Contact us promptly for any new bleeding after menopause. Don’t assume it’s just dryness or a medicine effect.

Clinical reference

  • Assess symptoms, examination where indicated, infection/dermatologic causes and the patient’s goals.
  • Offer moisturizers/lubricants and discuss local low-dose vaginal estrogen when appropriate; choose formulation from preference, usability, cost and clinical context.

Before explaining

Unexplained bleeding, concerning lesions or persistent focal pain requires evaluation. Prior hormone-sensitive cancer, especially aromatase-inhibitor use, needs individualized shared decision-making with relevant clinicians.

Warning signs

Postmenopausal bleeding needs prompt evaluation; heavy bleeding with faintness requires urgent/emergency care.

Follow-up

Review comfort, adverse effects and usability after several weeks, commonly 6–12 weeks. Ongoing therapy depends on benefit and preference; no automatic systemic-hormone regimen should be added.

Sources

Checked September 20, 2026.

Nipple discharge

What to say

Nipple discharge is common and usually isn’t cancer. Discharge from both nipples, or only when you squeeze, often comes from hormones, medicines or harmless duct changes.

Please stop squeezing, since that keeps it going. Discharge that is bloody, comes from one nipple, or starts on its own needs a breast exam and imaging. For milky discharge we may check pregnancy, prolactin and thyroid tests and review your medicines. Tell us promptly about a new lump or skin changes.

Clinical reference

Before explaining

Separate physiologic from pathologic discharge (spontaneous, unilateral, bloody). For milky discharge check pregnancy, medicines, prolactin and TSH.

Warning signs

Spontaneous bloody or single-nipple discharge, a lump, nipple or skin changes, or headache with vision change needs prompt workup.

Follow-up

Pathologic discharge: diagnostic imaging (ACR: ultrasound plus mammography from age 30, ultrasound alone under 30). Negative imaging but persistent pathologic discharge: refer to a breast specialist. Otherwise, re-examine within 1 year.

Sources

Checked October 15, 2026.

Ovarian cyst

What to say

An ovarian cyst is a fluid-filled sac on an ovary. Most are harmless, cause no symptoms, and go away on their own within weeks to months.

An ultrasound shows what kind it is, and its look and size decide whether we recheck it. If you’re past menopause, we’ll look more closely. Birth control pills don’t shrink a cyst you already have. Go to the emergency department for sudden, severe pelvic pain, especially with vomiting, fever or fainting.

Clinical reference

Before explaining

Do a pregnancy test. Use ultrasound features (O-RADS) and menopausal status to set follow-up; consider CA-125 for suspicious or postmenopausal cysts.

Warning signs

Sudden severe pelvic pain with nausea or vomiting suggests torsion or rupture; fever, fainting, or pain with a positive pregnancy test needs emergency evaluation.

Follow-up

Repeat ultrasound only as the imaging features advise; refer complex, growing or persistent cysts and suspicious postmenopausal cysts.

Sources

Checked October 15, 2026.

Painful periods

What to say

Cramping during periods is common, but pain that stops normal activities deserves treatment and sometimes investigation.

Heat and appropriate pain relief can help. Hormonal treatment is another option if it suits your goals. New or worsening pain may point to endometriosis or another cause.

Clinical reference

Before explaining

Assess pregnancy possibility, bleeding, infection symptoms and secondary dysmenorrhea features.

Warning signs

Sudden severe pelvic pain, fainting, fever or pain with possible pregnancy needs urgent assessment.

Follow-up

Review pain and function after treatment; investigate persistent or progressive symptoms.

Sources

Checked September 24, 2026.

Painful sex

What to say

Pain with sex is common and often treatable. Causes include vaginal dryness, tight pelvic floor muscles, skin conditions, infections and endometriosis.

We’ll ask when and where it hurts and usually do an exam. Lubricant, moisturizer, low-dose vaginal estrogen after menopause, pelvic floor physical therapy, and sex therapy can help. Call us if pain comes with fever, unusual discharge or bleeding, or if pelvic pain is severe or getting worse.

Clinical reference

Before explaining

Take a sexual history; examine vulva, vagina and pelvic floor. Consider infection, pregnancy, GSM, vulvodynia, lichen sclerosus, endometriosis, medicines and trauma.

Warning signs

Pain with fever, abnormal discharge or pelvic tenderness needs same-day STI and PID evaluation; sudden severe pelvic pain needs emergency assessment.

Follow-up

Review response to lubricant, vaginal estrogen or pelvic floor therapy in several weeks; refer to gynecology or a pelvic pain specialist if unresolved.

Sources

Checked October 15, 2026.

Pelvic inflammatory disease

What to say

An infection in the upper reproductive tract can cause pelvic pain and may affect future fertility. Treatment should start promptly when the examination supports it.

You’ll need a full antibiotic course and close review. Partners may need treatment, and you should avoid sex until treatment is complete, symptoms resolve and partners are treated.

Clinical reference

Before explaining

Check pregnancy/ectopic risk, severity, STI testing and abscess risk; do not delay necessary treatment awaiting tests.

Warning signs

Severe pain, vomiting, pregnancy, fainting or systemic illness may require hospital assessment.

Follow-up

Reassess within 72 hours; lack of improvement requires escalation.

Sources

Checked September 24, 2026.

Pelvic organ prolapse

What to say

The support tissues in the pelvis have weakened, allowing an organ to bulge toward or into the vagina. It can cause pressure or bladder and bowel symptoms.

Treatment depends on how much it bothers you. Pelvic-floor therapy, a fitted support called a pessary, or surgery are options we can discuss.

Clinical reference

Before explaining

Assess prolapse, urinary emptying, bowel symptoms, vaginal tissue and patient goals.

Warning signs

Inability to urinate, severe pain, ulceration or bleeding needs prompt review.

Follow-up

Arrange pessary care if used and review comfort, emptying and function.

Sources

Checked September 24, 2026.

Perimenopause and hot flashes

What to say

Hormone changes around menopause can cause hot flashes, disrupted sleep and other symptoms. The experience varies, and treatment can be tailored to you.

We can discuss hormone therapy and nonhormonal options based on your symptoms and medical history. Hormone therapy isn’t contraception, so pregnancy prevention may still matter.

Clinical reference

Before explaining

Review bleeding pattern, uterus status, pregnancy potential, breast cancer/clot/cardiovascular history and treatment risks.

Warning signs

Unexpected or persistent bleeding needs evaluation; new chest pain, breathlessness or neurologic symptoms requires urgent care.

Follow-up

Review symptom response, bleeding and treatment risks after starting or changing therapy.

Sources

Checked September 24, 2026.

Planning a pregnancy

What to say

Planning ahead helps. Start a daily vitamin with at least 400 micrograms of folic acid a month before trying, and bring your medicines to a visit. Don’t stop any on your own; some are unsafe in pregnancy.

We’ll update vaccines (wait a month after MMR or chickenpox shots), check diabetes, blood pressure and thyroid, and talk about avoiding alcohol, tobacco and cannabis. If you’re not pregnant after 12 months of trying, or 6 months if you’re over 35, tell us.

Clinical reference

Before explaining

Review medicines for pregnancy risk (for example ACE inhibitors/ARBs, isotretinoin, valproate, methotrexate, warfarin), rubella and varicella immunity, and disease control. Prior neural tube defect needs 4 mg folic acid.

Warning signs

Don’t stop essential medicines (seizure, mental health, anticoagulant) without a plan. Pregnancy on a high-risk medicine needs prompt review.

Follow-up

Review family history and discuss carrier screening. Evaluate infertility after 12 months (6 months if over 35; now if over 40).

Sources

Checked October 15, 2026.

Polycystic ovary syndrome

What to say

PCOS can affect ovulation, periods, skin or hair and metabolic health. The name doesn’t mean ovarian cysts are required for the diagnosis.

We’ll tailor treatment to what matters to you, whether that’s regular bleeding, acne, hair growth or pregnancy. We’ll also address blood-sugar risk and protecting the uterine lining when periods are very infrequent.

Clinical reference

Before explaining

Exclude pregnancy and competing endocrine causes; assess androgen symptoms, metabolic risks and prolonged anovulation.

Warning signs

Rapid virilization or severe new pelvic pain needs a separate prompt assessment.

Follow-up

Review menstrual/endometrial protection, metabolic screening and fertility goals.

Sources

Checked September 24, 2026.

Premenstrual dysphoric disorder (PMDD)

What to say

Premenstrual dysphoric disorder, or PMDD, causes severe irritability, low mood or anxiety in the 1 to 2 weeks before your period, easing within a few days after it starts. Daily symptom tracking for 2 cycles helps confirm it.

Options include an antidepressant, taken daily or just in the second half of your cycle, certain birth control pills, therapy and exercise. For thoughts of self-harm, even only before periods, call us the same day; in a crisis, call 988 or 911.

Clinical reference

Before explaining

Confirm luteal-only symptoms with prospective daily ratings over 2 cycles. Distinguish premenstrual worsening of depression, anxiety or bipolar disorder.

Warning signs

Suicidal thoughts need same-day assessment. Drospirenone COCs raise VTE risk; check estrogen contraindications. Symptoms persisting after menses suggest another disorder.

Follow-up

SSRIs act quickly here, so continuous or luteal-only dosing works. Review the diary after a few cycles; consider a drospirenone COC or CBT.

Sources

Checked October 15, 2026.

Uterine fibroids

What to say

Fibroids are usually noncancerous growths in the muscle of the uterus. Some cause heavy bleeding or pressure, while others need no treatment.

We’ll match treatment to your symptoms, anemia and pregnancy plans. Medicines can help bleeding, and procedures may be considered when symptoms remain troublesome.

Clinical reference

Before explaining

Assess pregnancy, bleeding, anemia, bulk symptoms and imaging; consider endometrial evaluation when indicated.

Warning signs

Severe pain, heavy bleeding with faintness or any bleeding after menopause needs prompt assessment.

Follow-up

Review symptom burden and anemia; arrange procedural consultation if appropriate.

Sources

Checked September 24, 2026.

Vaginal yeast infection

What to say

Yeast can cause itching, irritation and discharge, but several other conditions feel similar. This isn’t usually a sexually transmitted infection.

We’ll use an antifungal treatment suited to your situation. If symptoms persist or keep returning, testing is more useful than repeatedly treating presumed yeast.

Clinical reference

Before explaining

Confirm typical findings or test when uncertain; assess pregnancy, diabetes, recurrence and immune status.

Warning signs

Fever, pelvic pain, sores or persistent symptoms needs reassessment for another cause.

Follow-up

Review unresolved or recurrent symptoms; avoid repeated unconfirmed treatment.

Sources

Checked September 24, 2026.

Vulvar itching and lichen sclerosus

What to say

Vulvar itching has many causes, including yeast, irritants and lichen sclerosus, a long-term condition that leaves skin white, thin and itchy. An exam, sometimes with a small skin sample, tells us which.

Lichen sclerosus is treated with a strong steroid ointment, clobetasol, daily at first and then less often. It controls symptoms but isn’t a cure. Avoid scented products and scratching. Tell us about a new lump, open sore, or spot that bleeds or won’t heal.

Clinical reference

Before explaining

Examine vulvar and perianal skin; biopsy if the diagnosis is uncertain, response is poor, or a lump, ulcer or erosion appears.

Warning signs

A new ulcer, lump or non-healing area needs biopsy for squamous cell carcinoma (up to 5% of vulvar cases). Scarring can cause painful sex or urination.

Follow-up

Reassess within weeks, step down to the lowest effective maintenance, and arrange long-term follow-up for scarring and early cancer detection.

Sources

Checked October 15, 2026.

Digestive & liver health

Abdominal pain requiring assessment

What to say

Belly pain has many causes, and how much it hurts doesn’t always show how serious it is. Call us the same day for pain with fever or ongoing vomiting, or pain not improving within 1 to 2 days.

Go to the emergency department, or call 911, for sudden or severe pain, pain moving to the lower right belly, a hard, tender belly, vomiting blood, black or bloody stool, fainting, pain after an injury, or pain when you could be pregnant. Don’t drive yourself.

Clinical reference

Before explaining

Check vitals, peritoneal signs and pregnancy. Lower the threshold for older, immunosuppressed or cancer patients, whose presentations can be atypical.

Warning signs

Possible appendicitis, obstruction, GI bleeding, bowel ischemia, AAA, ectopic pregnancy or referred cardiac pain needs emergency evaluation.

Follow-up

If managed as an outpatient, give timed review and explicit return precautions; reassess persistent or recurrent pain with targeted tests or imaging.

Sources

Checked October 15, 2026.

Acute diarrhea and gastroenteritis

What to say

A short episode of diarrhea or vomiting often comes from an infection and improves with time. The immediate priority is replacing fluid and salts.

Take small, frequent drinks. An oral rehydration solution can help when losses are substantial. Wash hands carefully and avoid preparing food for others while ill.

Clinical reference

Before explaining

Assess hydration, travel/exposure, recent antibiotics, pregnancy, immune status and need for stool testing.

Warning signs

Bloody stool, severe abdominal pain, confusion, very little urine or inability to keep fluids down needs urgent care.

Follow-up

Reassess if symptoms persist, worsen or recovery is not following the expected course.

Sources

Checked September 24, 2026.

Anal fissure

What to say

A fissure is a small tear at the anal opening. It often causes sharp pain with a bowel movement and a little bright-red blood.

Soft stools and warm baths can reduce irritation. If it doesn’t heal, a prescription ointment or specialist treatment may help relax the muscle and allow healing.

Clinical reference

Before explaining

Confirm typical fissure; assess constipation, atypical location, inflammatory disease and other bleeding causes.

Warning signs

Fever, swelling, pus or constant worsening pain may mean an abscess and needs urgent review.

Follow-up

Reassess healing and bowel habits; refer persistent or atypical fissures.

Sources

Checked September 24, 2026.

Anal itching

What to say

Anal itching is common and usually comes from moisture, irritation, hemorrhoids, or harsh cleaning. Scratching makes it worse.

Rinse gently with water after bowel movements, pat dry, and use unscented wipes. Try a barrier cream or an over-the-counter hydrocortisone cream for a short time, as the package directs, and wear cotton underwear. Call us if there’s bleeding, a lump, a rash or fever, or no improvement in 2 to 3 weeks.

Clinical reference

Before explaining

Examine perianal skin and anorectum; consider hemorrhoids, fissure, dermatitis, fungal or STI causes, pinworms, diabetes, diarrhea and irritating foods.

Warning signs

Bleeding, a lump, ulcer, discharge, fever, or itching beyond 2–3 weeks needs examination to exclude serious anorectal disease.

Follow-up

Reassess in 2–3 weeks if symptoms persist; limit topical steroid to a short course; treat any underlying cause.

Sources

Checked October 15, 2026.

Barrett esophagus

What to say

Barrett esophagus is a change in the food pipe’s lining from long-term acid reflux. Most people never develop cancer, but the risk is a little higher, so we keep watch.

We treat reflux with a daily acid-reducing medicine and recheck with a scope, often every 3 to 5 years; precancerous cells, if found, can be treated through the scope. Tell us about trouble swallowing or weight loss. Vomiting blood or black stools means go to the emergency department.

Clinical reference

Before explaining

Confirm biopsy-proven Barrett (≥1 cm) and dysplasia grade. ACG: surveillance every 3–5 years without dysplasia; AGA 2025 suggests surveillance and daily PPI.

Warning signs

Dysphagia, unintentional weight loss, persistent vomiting or GI bleeding needs prompt endoscopy; vomiting blood or black stools is an emergency.

Follow-up

Schedule surveillance by dysplasia status and segment length; send confirmed dysplasia for endoscopic treatment; review PPI use and reflux control.

Sources

Checked October 15, 2026.

Bloating and lactose intolerance

What to say

Bloating is common and often comes from gas, constipation, or trouble digesting lactose, the sugar in milk.

For about 2 weeks, try cutting back on milk and ice cream, then add small amounts back to find your limit. Yogurt, hard cheeses, lactose-free milk and lactase pills are often easier. Tell us about weight loss without trying, blood in your stool, ongoing vomiting, or bloating that is new after 50 or won’t go away.

Clinical reference

Before explaining

Look for alarm features: weight loss, bleeding, anemia, persistent vomiting, onset after 50, or family history of GI cancer. Consider celiac testing and IBS.

Warning signs

Bloody or black stools, persistent vomiting, severe pain with fever, a lump, or no stool or gas needs urgent assessment. Persistent bloating in women can signal ovarian cancer.

Follow-up

Review the 2-week dairy trial and diary. Treat constipation; involve a dietitian for any further restriction and to keep calcium and vitamin D adequate.

Sources

Checked October 15, 2026.

C. difficile infection

What to say

C. diff is a germ that causes watery diarrhea, usually during or after antibiotics. A stool test confirms it, and treatment is an antibiotic by mouth, usually vancomycin or fidaxomicin.

Skip anti-diarrhea medicines unless we advise them. Wash your hands with soap and water after using the toilet, and clean the bathroom with a product labeled to kill C. diff. It can come back, so tell future prescribers. Severe belly pain or swelling, high fever, fainting or very little urine means go to the emergency department.

Clinical reference

Before explaining

Test only new, unexplained ≥3 unformed stools in 24 hours, not on laxatives. Stop unneeded antibiotics; review PPI indication.

Warning signs

Severe: WBC ≥15,000/mm³ or creatinine >1.5 mg/dL. Fulminant: hypotension, shock, ileus or megacolon needs hospital care. Avoid antimotility agents.

Follow-up

Expect improvement within days. No test of cure. Recurrence: fidaxomicin or vancomycin taper/pulse; FMT or microbiome therapy after multiple recurrences.

Sources

Checked October 15, 2026.

Celiac disease

What to say

Celiac disease is an immune reaction to gluten that can injure the small intestine and affect nutrition. It can occur even without obvious diarrhea.

If we’re still testing, keep eating gluten unless your specialist advises otherwise, because stopping can hide the diagnosis. Once confirmed, treatment is a lifelong gluten-free diet with nutritional support.

Clinical reference

Before explaining

Use appropriate serology with total IgA and confirmatory pathway; assess anemia and nutritional/bone effects.

Warning signs

Severe dehydration, bleeding or progressive unexplained weight loss needs prompt assessment.

Follow-up

Review diagnostic results, dietitian access, symptoms and correction of deficiencies.

Sources

Checked September 24, 2026.

Chronic hepatitis B

What to say

Chronic hepatitis B is a lasting liver infection. Many people feel well, but it can scar the liver or cause liver cancer.

We’ll check blood tests regularly, often every 6 months; some people need daily antiviral pills. Depending on your risk, you may need a liver ultrasound every 6 months. Tell anyone prescribing you medicine, since some treatments can make it flare. Household and sex partners should be tested and vaccinated. Limit alcohol.

Clinical reference

Before explaining

HBsAg positive >6 months. Check HBeAg, HBV DNA, ALT, fibrosis (FIB-4/elastography), HIV, HCV, HAV immunity; HDV if at risk.

Warning signs

Jaundice or confusion: urgent. Chemotherapy, rituximab, other immunosuppressants or HCV antivirals can reactivate HBV; plan prophylaxis or monitoring first.

Follow-up

ALT and HBV DNA every 3–6 months in year 1, then every 6–12 (phase-dependent). HCC ultrasound ± AFP every 6 months per AASLD risk criteria.

Sources

Checked October 15, 2026.

Cirrhosis

What to say

Cirrhosis is scarring of the liver, often from alcohol, fatty liver or hepatitis. Scarring usually doesn’t go away, but treating the cause protects the liver you have.

Drink no alcohol, and check with us before any medicine or supplement. Avoid ibuprofen and naproxen, and limit acetaminophen to 2,000 milligrams a day. We’ll arrange a liver ultrasound every 6 months and update your vaccines. Go to the emergency department for confusion, vomiting blood, black stools, or fever with a swollen belly.

Clinical reference

Before explaining

Confirm cause and decompensation status; assess variceal risk; liver ultrasound with AFP every 6 months; review all medicines and supplements; refer to hepatology.

Warning signs

Confusion, vomiting blood, black stools, or fever with abdominal swelling needs emergency care; new jaundice needs same-day review. Avoid NSAIDs.

Follow-up

Update hepatitis A and B, influenza, COVID-19 and RSV (age 50+) vaccines; dietitian input on protein and calories; limit sodium if ascites or edema.

Sources

Checked October 15, 2026.

Constipation

What to say

The goal is a soft, comfortable bowel movement without straining, not necessarily a bowel movement every day. Medicines, changes in routine, diet and some health conditions can all contribute, so we’ll look for a reason as well as offer relief.

We can start with gradual changes in fiber and activity and use the stool-softening plan we discussed. If we use polyethylene glycol, it may take one to three days. Don’t keep adding doses for an immediate result. Severe or worsening belly pain, a swollen belly with vomiting, or inability to pass gas means go to the emergency department. Tell me about bleeding, weight loss or a persistent new change in your bowel pattern, even if the laxative helps.

Clinical reference

  • Review stool consistency, straining, medication contributors, diet, mobility and possible pelvic-floor issues.
  • For an uncomplicated adult, PEG 3350 17 g daily is a common option; individualize duration and response review.

Before explaining

Assess obstruction/alarm symptoms, fecal impaction when suspected, renal/fluid restrictions and age-appropriate cancer evaluation. Do not prescribe repeated laxatives without reassessing a new persistent pattern.

Warning signs

Obstruction symptoms require emergency assessment. Persistent rectal bleeding or unexplained weight loss needs directed evaluation, not reassurance from laxative response.

Follow-up

Check initial response within several days and agree on an ongoing review if symptoms persist or recur. OTC PEG use beyond seven days needs an explicit clinician plan.

Sources

Checked September 20, 2026.

Difficulty swallowing

What to say

Food sticking, coughing with swallowing or trouble getting a swallow started needs assessment. Different patterns point to different problems.

We’ll decide whether you need a swallowing evaluation, an examination of the food pipe or both. Until then, follow the food and fluid advice we agree is safe for you.

Clinical reference

Before explaining

Assess solids/liquids, progression, aspiration, neurologic findings and weight loss.

Warning signs

Food stuck with inability to swallow saliva needs emergency care; choking or breathing difficulty means call 911.

Follow-up

Arrange prompt investigation and track results; reassess worsening intake.

Sources

Checked September 24, 2026.

Diverticulitis

What to say

Small pockets in the colon can become inflamed, causing persistent abdominal pain, often on the left. The severity determines whether home treatment is safe.

We’ll assess for complications and decide whether imaging, antibiotics or hospital care is needed. The plan should include pain relief, hydration and a clear check-in.

Clinical reference

Before explaining

Assess peritonitis, sepsis, immune status and diagnostic uncertainty; antibiotics are individualized in uncomplicated disease.

Warning signs

Worsening severe pain, rigid abdomen, vomiting or systemic illness needs urgent reassessment.

Follow-up

Review recovery and need for subsequent colon evaluation based on the episode and prior testing.

Sources

Checked September 24, 2026.

Fecal incontinence

What to say

Bowel leakage is a medical symptom, and there are ways to help. Loose stool, constipation with overflow, muscle injury or nerve problems can contribute.

A stool diary and examination help us choose treatment. We can work on stool consistency, toileting routines, skin protection and pelvic-floor support, with specialist input when needed.

Clinical reference

Before explaining

Assess impaction, diarrhea, obstetric/surgical history, medications and neurologic signs.

Warning signs

New bowel-control loss with back pain, saddle numbness or leg weakness needs emergency assessment.

Follow-up

Review leakage, stool consistency and effect on daily life.

Sources

Checked September 24, 2026.

Gallstones

What to say

Gallstones can block the flow of bile and cause upper abdominal pain. Stones found incidentally may need no treatment, while repeated attacks may lead to a surgery discussion.

We’ll check whether your pain fits and look for inflammation or blockage. Treatment depends on those findings rather than the scan alone.

Clinical reference

Before explaining

Assess pain duration, fever, jaundice, liver tests and ultrasound; consider pancreatitis.

Warning signs

Persistent severe pain, fever, jaundice or vomiting needs urgent hospital assessment.

Follow-up

Arrange review of imaging and a surgical opinion for symptomatic disease when indicated.

Sources

Checked September 24, 2026.

Groin or abdominal-wall hernia

What to say

A hernia is tissue pushing through a weak area in the abdominal wall. It may make a bulge more noticeable when standing or straining.

We’ll assess the type and symptoms and discuss observation or a surgical opinion. The plan changes urgently if the bulge becomes trapped and painful.

Clinical reference

Before explaining

Assess location, reducibility, pain and obstruction; tailor referral to hernia type and risk.

Warning signs

A painful firm bulge that will not reduce, vomiting or abdominal distension needs emergency assessment.

Follow-up

Review growth or discomfort and confirm surgical follow-up when indicated.

Sources

Checked September 24, 2026.

H. pylori infection

What to say

H. pylori is a stomach infection that can cause ulcers and increase future stomach-cancer risk. A combination of medicines can eradicate it.

Take the complete prescribed regimen, then we’ll test to make sure the infection is gone. Feeling better alone doesn’t prove eradication.

Clinical reference

Before explaining

Choose a current regimen using allergy and antibiotic history; avoid empiric clarithromycin triple therapy without susceptibility evidence.

Warning signs

Vomiting blood, black tarry stool, fainting or severe abdominal pain needs emergency assessment.

Follow-up

Test cure at least four weeks after antibiotics; hold PPI/PCAB two weeks and antibiotics/bismuth four weeks beforehand as directed.

Sources

Checked September 24, 2026.

Hemorrhoids

What to say

Hemorrhoids are swollen blood vessels around the anus that can itch, bulge or bleed. We shouldn’t automatically assume they explain every episode of rectal bleeding.

Keeping stools soft, avoiding straining and limiting time on the toilet can help. Short-term symptom treatment or an office procedure may be useful if symptoms persist.

Clinical reference

Before explaining

Examine as appropriate; assess bleeding pattern, anemia, bowel changes and colorectal evaluation needs.

Warning signs

Heavy ongoing bleeding, faintness, fever or severe anal pain needs urgent assessment.

Follow-up

Review persistent bleeding or symptoms despite stool-softening measures.

Sources

Checked September 24, 2026.

Hepatitis C

What to say

Hepatitis C is a virus that can slowly scar the liver, often without symptoms. A positive antibody test needs a viral load test to confirm current infection. Most people are cured with 8–12 weeks of pills.

We’ll check for liver scarring, test for hepatitis B and HIV, and offer hepatitis A and B vaccines if needed. Limit alcohol, and don’t share needles, razors or toothbrushes. You can catch it again after cure.

Clinical reference

Before explaining

Confirm HCV RNA. FIB-4 (>3.25 suggests cirrhosis) or elastography; HBsAg (reactivation risk), HIV, pregnancy; review drug interactions.

Warning signs

Jaundice, ascites, confusion or GI bleeding suggests decompensation: urgent specialist care. Cirrhosis needs ultrasound (± AFP) every 6 months, even after cure.

Follow-up

HCV RNA 12+ weeks after treatment confirms cure. Antibody stays positive; retest ongoing risk with RNA yearly.

Sources

Checked October 15, 2026.

Inflammatory bowel disease

What to say

Crohn’s disease and ulcerative colitis cause inflammation in the digestive tract. They’re different from IBS and need treatment aimed at controlling that inflammation.

We’ll coordinate with gastroenterology and make a clear plan for symptoms, medicines and monitoring. Don’t assume a new bout of diarrhea is always a flare. Infection can look similar.

Clinical reference

Before explaining

Assess severity, hydration, bleeding, anemia and stool infection testing; review immunosuppressive treatment.

Warning signs

Heavy bleeding, severe abdominal pain/distension, high fever or dehydration requires urgent hospital assessment.

Follow-up

Confirm specialist follow-up, response and medicine-specific monitoring.

Sources

Checked September 24, 2026.

Irritable bowel syndrome

What to say

IBS causes recurring abdominal pain with changes in bowel habits. The bowel can be unusually sensitive even without visible damage.

We’ll choose treatment for your main symptoms and look for manageable food or stress triggers. Any restrictive diet should have a clear trial and review, ideally with a dietitian.

Clinical reference

Before explaining

Make a positive symptom-based assessment after indicated testing; check bleeding, anemia, weight loss and family history.

Warning signs

New bleeding, unexplained weight loss, persistent vomiting or a major change in pattern needs reassessment.

Follow-up

Review a symptom/stool diary and the benefit of each intervention.

Sources

Checked September 24, 2026.

Metabolic fatty liver disease

What to say

Fat buildup in the liver can occur with metabolic conditions such as diabetes. Some people develop inflammation or scarring, so we need to assess more than the liver enzyme number.

We’ll review alcohol, medicines and other liver causes, estimate scarring risk and work on sustainable nutrition and activity. Treatment also includes protecting your heart and managing metabolic risks.

Clinical reference

Before explaining

Assess fibrosis risk and competing causes; consider elastography or referral based on results.

Warning signs

Jaundice, abdominal swelling, confusion or vomiting blood needs urgent assessment.

Follow-up

Set a fibrosis-risk and metabolic follow-up plan; refer concerning findings.

Sources

Checked September 24, 2026.

Persistent diarrhea

What to say

Diarrhea that keeps going needs a broader assessment than a brief stomach bug. Medicines, infections, inflammation and problems absorbing food can all cause it.

We’ll review the timing, stool pattern and exposures, then choose blood or stool tests that fit. Keep hydrated and avoid repeatedly masking symptoms without finding the cause.

Clinical reference

Before explaining

Review duration, nocturnal symptoms, blood, weight loss, drugs, travel and prior antibiotics.

Warning signs

Dehydration, bleeding, severe pain or fever with systemic illness needs urgent assessment.

Follow-up

Arrange results review and referral for alarm features or unexplained ongoing symptoms.

Sources

Checked September 24, 2026.

Rectal bleeding

What to say

Blood from the bowel can come from hemorrhoids or a tear, but it can also signal inflammation or a growth. We need to identify the source.

We’ll review the amount and pattern, examine as appropriate and decide what blood tests or bowel investigation are needed. Don’t let presumed hemorrhoids delay follow-up.

Clinical reference

Before explaining

Assess stability, anemia, bowel change, weight loss, medicines and family history; diagnostic evaluation differs from screening.

Warning signs

Heavy ongoing bleeding, black tarry stool, fainting or marked weakness needs emergency care.

Follow-up

Track testing to a documented explanation; persistent bleeding requires reassessment.

Sources

Checked September 24, 2026.

Reflux or upper-belly discomfort

What to say

Acid may be contributing to the burning or discomfort, so we can try reducing it for a set period and see how much that helps. Improvement would support this treatment, but it wouldn’t prove that every symptom was caused by acid.

If we need a test for the stomach bacterium H. pylori, we’ll coordinate that before the acid medicine affects the result. Otherwise, we’ll follow the short treatment plan we’ve chosen and review it in several weeks. Smaller meals and avoiding late large meals may help. You don’t need a long list of forbidden foods if they aren’t triggers for you. Call the same day for trouble swallowing or ongoing vomiting, and arrange a prompt visit for unintentional weight loss. Vomiting blood or black tarry stools needs emergency care.

Clinical reference

  • Separate typical reflux from dyspepsia and other causes. Select H. pylori testing, endoscopy or an empiric trial based on age, symptoms and risk.
  • A 4–8-week PPI trial can be appropriate for an uncomplicated presentation; indication determines the regimen and endpoint.

Before explaining

Review NSAIDs, bleeding/anemia, dysphagia, weight loss, persistent vomiting, family/risk history and possible cardiac symptoms. A response to PPI is not a definitive diagnostic test.

Warning signs

Possible cardiac chest pain, significant GI bleeding or severe acute abdominal pain needs an emergency pathway, not simply a higher PPI dose.

Follow-up

Reassess response and adherence/timing at 4–8 weeks; decide stop/taper, lowest effective maintenance, or further evaluation rather than automatic indefinite renewal.

Sources

Checked September 20, 2026.

Travelers’ diarrhea

What to say

Travelers’ diarrhea comes from germs in food or water and usually clears within a week. Careful food and drink choices may lower the risk, and bismuth (Pepto-Bismol) can prevent some cases but turns stool black.

Sip safe fluids, adding oral rehydration salts for heavy losses; loperamide can ease milder diarrhea. For severe diarrhea, fever or bloody stool, take your standby antibiotic if prescribed, or get care, and don’t use loperamide alone. Get care for dizziness, very little urine, or diarrhea lasting more than 2 weeks.

Clinical reference

Before explaining

Review itinerary and standby antibiotic need. Bismuth cautions: aspirin allergy, anticoagulants, kidney disease, gout, methotrexate, probenecid; not beyond 3 weeks.

Warning signs

Dysentery, fever, dehydration or no improvement after self-treatment needs assessment. After antibiotics, consider C. difficile.

Follow-up

Persistent diarrhea (>2 weeks): stool testing, including for parasites such as Giardia. Post-infectious IBS can follow.

Sources

Checked October 15, 2026.

Heart, circulation & metabolism

A very high blood pressure reading

What to say

A reading over 180 on top or 120 on the bottom needs attention. With chest, back or belly pain, trouble breathing, weakness or numbness, vision changes, trouble speaking or a sudden severe headache, call 911 now.

Without symptoms, sit quietly for 5 minutes and recheck. If it’s still that high, call us today. Most people without symptoms don’t need the emergency room; we’ll adjust your pills and recheck soon.

Clinical reference

Before explaining

Recheck with proper technique; assess for acute target organ damage; review missed doses, pain, NSAIDs, decongestants, stimulants and alcohol.

Warning signs

Chest pain, dyspnea, neurologic or visual deficits, confusion or severe headache suggest hypertensive emergency: send by ambulance.

Follow-up

Without target organ damage, start, restart or intensify oral therapy and recheck within days using home readings.

Sources

Checked October 15, 2026.

Abdominal aortic aneurysm

What to say

An abdominal aortic aneurysm is a bulge in the main belly artery. Small ones rarely burst, so we track the size with ultrasound. Repair is usually advised at about 5.5 centimeters (5 for women), or sooner if it grows fast or causes pain.

Stopping smoking matters most, along with blood pressure and cholesterol control. Call 911 for sudden severe belly or back pain or fainting. Brothers, sisters and grown children should ask about screening at 65.

Clinical reference

Before explaining

Confirm diameter and growth; treat BP and lipids (statin if atherosclerosis); support quitting smoking; avoid fluoroquinolones if alternatives exist.

Warning signs

Abdominal, back or flank pain, a tender aneurysm, syncope or hypotension suggests expansion or rupture: send to the ED.

Follow-up

Ultrasound every 3 years (3.0–3.9 cm), yearly (men 4.0–4.9, women 4.0–4.4 cm), every 6 months if larger; refer at ≥5.5 cm (men), ≥5.0 cm (women).

Sources

Checked October 15, 2026.

After a blood clot (DVT or PE)

What to say

After a clot in a leg vein or the lungs, a blood thinner for at least 3 months keeps it from growing while your body breaks it down. Whether to continue longer depends on what caused it and your bleeding risk.

Take every dose. On long trips, walk every 1–2 hours. Call us about new leg swelling or unusual bleeding, such as black stools. Call 911 for chest pain, sudden breathlessness or coughing blood.

Clinical reference

Before explaining

Classify provoked vs unprovoked; assess bleeding risk, interacting drugs (NSAIDs, antiplatelets), estrogen use and any cancer symptoms.

Warning signs

Recurrent DVT or PE symptoms, major bleeding, or chronic leg pain and swelling (post-thrombotic syndrome).

Follow-up

Review at 3 months: stop after a resolved transient provoking factor; weigh extended therapy if unprovoked or risk persists; review yearly.

Sources

Checked October 15, 2026.

Atrial fibrillation

What to say

Atrial fibrillation is an irregular heart rhythm. It can cause symptoms and may raise the risk of a stroke even when you don’t feel it.

We’ll discuss controlling the rate or rhythm and whether a blood thinner would reduce your stroke risk. The choice depends on your overall risk and bleeding concerns.

Clinical reference

Before explaining

Confirm ECG; assess stability, triggers, stroke/bleeding risk, renal function and valve disease.

Warning signs

Chest pain, severe breathlessness, fainting or stroke symptoms requires emergency assessment.

Follow-up

Review rate/rhythm symptoms and anticoagulant dose, adherence and monitoring.

Sources

Checked September 24, 2026.

Chest pain requiring assessment

What to say

Chest pain can come from the heart, lungs, muscles or digestive tract. We shouldn’t label a new concerning episode as reflux or anxiety without assessment.

If you have ongoing pressure or pain with breathlessness, sweating, nausea or faintness, call 911 now. Don’t drive yourself or wait for a portal reply.

Clinical reference

Before explaining

Assess acuity and cardiopulmonary threats immediately; a reassuring history alone cannot exclude an emergency.

Warning signs

Persistent/new severe chest pain, radiation to arm/jaw/back or associated collapse requires emergency care.

Follow-up

After acute causes are assessed, arrange cause-specific treatment and follow-up.

Sources

Checked September 24, 2026.

Chronic kidney disease

What to say

These findings suggest your kidneys have a lasting change in function or damage. The stage and urine protein level help estimate the risk. This doesn’t automatically mean dialysis.

We’ll focus on slowing progression and protecting your heart through blood-pressure control, suitable medicines and avoiding kidney stressors. Check before using anti-inflammatory pain medicines.

Clinical reference

Before explaining

Confirm chronicity, eGFR trend and albuminuria; assess cause, electrolytes and drug dosing.

Warning signs

Markedly reduced urine, severe breathlessness, confusion or acute illness with dehydration needs urgent review.

Follow-up

Set stage- and treatment-specific blood/urine monitoring and referral criteria.

Sources

Checked September 24, 2026.

Diabetic foot care

What to say

Diabetes can dull feeling and slow blood flow in your feet, so a small blister can become a serious sore before you notice.

Check your feet daily, using a mirror or a helper. Wash and dry them, moisturize but not between your toes, and cut nails straight across. Always wear socks and shoes that fit, and don’t smoke. Call us the same day about a new sore, redness, warmth or swelling; get urgent care for fever or spreading redness.

Clinical reference

Before explaining

Inspect feet every visit if high risk; at least yearly, test 10-g monofilament plus one other sensory test and check pedal pulses.

Warning signs

Ulcer, infection, gangrene, or a warm, red, swollen foot (possible Charcot) needs same-day assessment; offload and refer urgently.

Follow-up

Refer high-risk feet to podiatry and therapeutic footwear; reduced or absent pulses need ABI with toe pressures.

Sources

Checked October 15, 2026.

Fainting

What to say

Fainting is a brief loss of consciousness from reduced blood flow to the brain. Some causes are benign, but heart rhythm and other serious problems must be considered.

We’ll review what happened before, during and after the episode, check your heart and blood pressure, and decide what testing is needed. Avoid driving until we clarify safety advice.

Clinical reference

Before explaining

Obtain witness history when possible; assess ECG, exertional/supine episodes, injury and family history.

Warning signs

Incomplete recovery, chest pain, exertional fainting or new neurologic signs needs emergency assessment.

Follow-up

Arrange timely review and explicit driving/activity guidance based on cause and local rules.

Sources

Checked September 24, 2026.

Heart failure

What to say

Heart failure means the heart isn’t filling or pumping well enough for the body’s needs. It doesn’t mean it has stopped working, and treatment can improve symptoms and outcomes.

We’ll match treatment to your heart function and give you a plan for weight, swelling and breathing changes. Don’t change doses unless we have agreed on a specific plan.

Clinical reference

Before explaining

Review ejection fraction, volume status, renal function, potassium and guideline-directed treatment eligibility.

Warning signs

Severe breathlessness at rest, chest pain, fainting or confusion needs emergency care.

Follow-up

Arrange early review after treatment changes and individualized weight/symptom thresholds for contacting the team.

Sources

Checked September 24, 2026.

Heart murmur and aortic stenosis

What to say

A heart murmur is an extra whooshing sound. Many are harmless, but some signal a valve problem like aortic stenosis, where the valve at the heart’s exit narrows.

We’ll check the valve with an ultrasound. Milder narrowing is watched with repeat scans, and severe narrowing with symptoms is treated by valve replacement. Keep up dental care, tell us about breathlessness or chest pressure with activity, and go to the emergency department if you faint.

Clinical reference

Before explaining

Echo for suspected valve disease or symptoms. Native-valve AS needs no dental antibiotic prophylaxis; prosthetic valves, including TAVR, qualify.

Warning signs

Exertional breathlessness, chest pain or near-fainting needs prompt assessment, as symptomatic aortic stenosis changes management; fainting needs emergency care.

Follow-up

Asymptomatic: echo every 3–5 years (mild), 1–2 years (moderate), 6–12 months (severe); cardiology if severe or symptomatic; stress dental hygiene.

Sources

Checked October 15, 2026.

High blood pressure

What to say

Your blood pressure has been above the range we want on repeated measurements. High blood pressure often causes no symptoms, but over time it puts extra strain on the heart, brain and kidneys. Treatment lowers that future risk even if you feel exactly the same.

We’ll choose a blood-pressure goal that fits your health and start with the changes and medicine we’ve discussed. At home, use a correctly sized upper-arm cuff, sit quietly for five minutes, and take two readings a minute apart. Take readings on [schedule] until [date], and bring the readings and cuff to our review. If treatment makes you dizzy, tell me so we can adjust it.

If the top number is over 180 or the bottom number is over 120, and you have chest pain, trouble breathing, weakness, trouble speaking or vision changes, call 911 without waiting to repeat it. Without those symptoms, rest quietly for 5 minutes and check again. If it’s still that high, contact us immediately. Don’t take extra doses on your own.

Clinical reference

  • Confirm diagnosis with appropriate repeated and out-of-office measurements when indicated.
  • Choose lifestyle treatment and medication from BP level, ASCVD risk, comorbidities and tolerability. A target below 130/80 mm Hg is common, with individualization.

Before explaining

Assess possible acute target-organ injury, orthostasis, secondary contributors, pregnancy, renal function, electrolytes and medications. Do not infer that one routine office value establishes the whole treatment plan.

Warning signs

If systolic BP is >180 OR diastolic BP >120 mm Hg with chest pain, severe breathlessness, neurologic or visual symptoms, call 911 without waiting to repeat. Without symptoms, repeat after 5 minutes of rest; if still that high, contact the clinician immediately. Do not advise unsupervised extra doses.

Follow-up

Arrange a near-term BP review, commonly about one month after starting/changing treatment, with earlier drug-specific labs and earlier symptom review when indicated.

Sources

Checked September 20, 2026.

High cholesterol and cardiovascular risk

What to say

Cholesterol is one part of your chance of having a heart attack or stroke. I’m looking at it alongside your blood pressure, smoking history, diabetes, kidney health and any previous heart or blood-vessel problems.

For you, the decision is whether the expected reduction in that risk is worth taking a daily medicine, along with changes in food and activity. We can discuss your estimated risk and how treatment might change it while remembering that these are estimates and can’t predict exactly what will happen to you. If we start a statin, you probably won’t feel a benefit day to day. We’ll check the cholesterol response and how you tolerate it. What concerns you most about taking a medicine long term?

Clinical reference

  • Use the current risk framework, baseline LDL/non-HDL, ASCVD history and relevant risk enhancers.
  • 2026 ACC/AHA guidance uses PREVENT-ASCVD in eligible primary-prevention adults; choose statin intensity and goals for the applicable risk group.

Before explaining

Check familial/severe hypercholesterolemia, secondary causes, liver history, interactions and pregnancy plans. Do not use the same numerical benefit estimate for every patient.

Warning signs

Severe muscle weakness/pain with dark urine or systemic illness needs prompt medication hold and emergency evaluation; ordinary mild aches merit assessment and options rather than silent abandonment.

Follow-up

Recheck lipids about 4–12 weeks after initiation or dose adjustment. Review adherence, side effects and whether treatment reaches the intended reduction/goal.

Sources

Checked September 20, 2026.

High triglycerides

What to say

Triglycerides are a type of blood fat. They rise with extra calories, sugar, alcohol, weight gain, diabetes, an underactive thyroid and some medicines.

We’ll look for these causes and treat them first. Less alcohol and sugar, more activity and weight loss lower levels, and some people also need a medicine. Very high levels can inflame the pancreas, so go to the emergency department for severe belly pain.

Clinical reference

Before explaining

Look for secondary causes (diabetes, alcohol, hypothyroidism, kidney or liver disease, medicines). Levels of 500 mg/dL or higher raise pancreatitis risk.

Warning signs

Severe or persistent upper-abdominal pain, especially with vomiting, may be pancreatitis and needs emergency care.

Follow-up

Recheck lipids after cause and lifestyle changes. Statin for cardiovascular risk; fenofibrate or icosapent ethyl only in selected patients.

Sources

Checked October 15, 2026.

Hyperthyroidism

What to say

An overactive thyroid can make the heart race and cause heat intolerance, tremor or weight loss. We need to identify why it’s overactive.

Treatment may control symptoms and reduce thyroid activity, with specialist input depending on the cause. We’ll explain medicine-specific warning signs before treatment starts.

Clinical reference

Before explaining

Confirm thyroid tests and cause; assess rhythm, pregnancy, eye disease and treatment suitability.

Warning signs

High fever, confusion, severe agitation or a very fast heartbeat needs emergency assessment.

Follow-up

Arrange timely treatment review and repeat thyroid testing; monitor medication-specific harms.

Sources

Checked September 24, 2026.

Hypothyroidism

What to say

An underactive thyroid makes too little thyroid hormone. It can contribute to tiredness, constipation and feeling cold, though these symptoms have other causes too.

If replacement treatment is indicated, we’ll choose a dose and recheck blood levels after changes. Taking it consistently and separating it from interfering medicines helps it work.

Clinical reference

Before explaining

Interpret TSH/free T4 in context; consider pregnancy, cardiac disease, adherence and interactions.

Warning signs

New chest pain, marked palpitations or severe worsening symptoms requires prompt assessment.

Follow-up

Recheck thyroid tests after an appropriate dose-adjustment interval, then periodically when stable.

Sources

Checked September 24, 2026.

Leg swelling

What to say

Swollen legs can come from vein problems, medicines or heart, kidney and liver conditions. One newly swollen leg has a different set of concerns from gradual swelling in both.

We’ll examine you and choose tests based on the pattern. Treatment should address the cause. Water pills and compression aren’t right for every situation.

Clinical reference

Before explaining

Assess asymmetry, onset, cardiopulmonary symptoms, medication causes and arterial circulation before compression.

Warning signs

Sudden painful one-sided swelling needs same-day review; breathlessness or chest pain means emergency care.

Follow-up

Review the identified cause and response to treatment.

Sources

Checked September 24, 2026.

Low blood sugar

What to say

Low blood sugar is a reading under 70. You may feel shaky, sweaty, hungry or confused. It’s most likely with insulin or pills like glipizide, especially after a skipped meal, alcohol or extra exercise.

Take 15 grams of fast sugar, like 4 glucose tablets or half a cup of juice, then recheck in 15 minutes and repeat if needed. Check before you drive. If you pass out, someone should give glucagon and call 911. Tell us about any low.

Clinical reference

Before explaining

Review insulin/sulfonylurea doses, meal timing, alcohol, exercise and falling eGFR; ask about unawareness, nighttime lows and driving.

Warning signs

Severe lows (needed help), readings <54 mg/dL, unawareness or nighttime lows: reduce or change causative drugs; prescribe glucagon.

Follow-up

Review meter or CGM data after any change; consider CGM for unawareness or frequent lows.

Sources

Checked October 15, 2026.

Muscle symptoms on a statin

What to say

Muscle aches are common, but in large studies most aches in people taking statins weren’t caused by the statin. Serious muscle damage is rare.

Please talk with us before stopping, since the statin protects your heart. We may pause it, then try a lower dose, a different statin or another cholesterol medicine. For severe pain, weakness or dark, cola-colored urine, stop it and call us the same day.

Clinical reference

Before explaining

Check CK if symptoms are severe or with weakness, and TSH; review dose, interacting drugs, age ≥65 and kidney function.

Warning signs

Markedly raised CK, weakness, dark urine or AKI suggests myopathy or rhabdomyolysis: stop the statin and assess urgently.

Follow-up

Once symptoms settle, rechallenge, switch statin or try nondaily rosuvastatin or atorvastatin (off-label); add nonstatin therapy if needed. Vitamin D doesn’t prevent symptoms.

Sources

Checked October 15, 2026.

New type 2 diabetes

What to say

Your results show diabetes: sugar is staying higher in the blood than it should. This is treatable, and we can work on it step by step. The plan is about protecting your health and helping you feel well, not judging what you have eaten.

We’ll choose a blood-sugar goal, talk about meals and activity that are realistic for you, and select medicine based on your whole health, including your heart and kidneys. You may not need every kind of home test. I’ll explain which readings will actually help us. We’ll also arrange the eye, kidney and foot checks that help catch problems early. Please tell me what feels hardest about starting this plan so we can address it now.

If you’re vomiting and can’t keep food or drinks down, go to the emergency department. Fast or difficult breathing or confusion means call 911. These can be signs of a serious blood-sugar emergency.

Clinical reference

  • Confirm an asymptomatic diagnosis with a second abnormal measurement; assess diabetes type and severity.
  • Medication selection depends on glycemia, ASCVD/HF/CKD, weight priorities, hypoglycemia risk, access and patient preference. Marked symptomatic hyperglycemia may require insulin and urgent assessment.

Before explaining

Assess weight loss, ketotic symptoms, pregnancy, renal function, current medicines, food access and ability to use the proposed treatment. Do not use a generic metformin-first script for every patient.

Warning signs

Vomiting, abdominal pain, dehydration, rapid breathing, confusion or inability to maintain intake needs emergency assessment. Supply a concrete low-glucose plan if treatment can cause hypoglycemia.

Follow-up

Arrange an early medication/tolerability review and A1c around three months after a change; individualize eye, kidney, foot and cardiovascular prevention follow-up.

Sources

Checked September 20, 2026.

Obesity and weight management

What to say

Weight is affected by biology, environment, medicines and daily circumstances. We can focus on health and function without blaming you.

If you want to work on this, we can build a sustainable plan and discuss nutrition support, medication or surgery when appropriate. Your priorities and access to treatment matter.

Clinical reference

Before explaining

Ask permission to discuss weight; assess complications, medications, eating disorders, pregnancy plans and treatment eligibility.

Warning signs

Rapid unintended weight change or concerning eating behaviors needs separate assessment.

Follow-up

Agree on health/function goals and treatment-specific follow-up, including adverse effects.

Sources

Checked September 24, 2026.

Orthostatic dizziness

What to say

Your blood pressure may be dropping when you stand, briefly reducing blood flow to the brain. Medicines, dehydration and other conditions can contribute.

Rise in stages and sit or lie down if you feel faint. We’ll review the cause and tailor fluid or other advice to your heart and kidney health.

Clinical reference

Before explaining

Measure lying/standing BP and pulse; review falls, bleeding, dehydration and medicines.

Warning signs

Fainting, chest pain, neurologic symptoms or suspected bleeding needs urgent assessment.

Follow-up

Review standing symptoms and readings after correcting contributors.

Sources

Checked September 24, 2026.

Palpitations

What to say

Feeling a racing, fluttering or skipped heartbeat has several possible causes. We need to match the sensation with your heart rhythm when possible.

We’ll review triggers and medicines, do an ECG and consider a monitor if episodes come and go. Note the timing, duration and any other symptoms.

Clinical reference

Before explaining

Assess exertional symptoms, syncope, family history, substances and relevant blood tests.

Warning signs

Palpitations with chest pain, breathlessness or fainting means emergency assessment.

Follow-up

Review monitor/test results and recurring episodes; do not leave testing without a follow-up plan.

Sources

Checked September 24, 2026.

Pericarditis

What to say

Pericarditis is inflammation of the sac around your heart. The sharp chest pain is usually worse lying down or breathing in and better sitting forward.

We’ll check your heart first, since chest pain always needs assessment. Treatment is ibuprofen or aspirin at the dose we prescribe for days to weeks, plus colchicine, used off-label, for at least 3 months. No hard exercise until we clear you; go to the emergency department for fever, fainting or trouble breathing.

Clinical reference

Before explaining

Rule out acute coronary syndrome and myocarditis (ECG, troponin, echo); check NSAID and colchicine contraindications and interactions.

Warning signs

Fever above 38 °C, large effusion, tamponade or NSAID failure needs hospital assessment; fainting or severe breathlessness is an emergency.

Follow-up

Reassess in 1–2 weeks. Colchicine for at least 3 months; no strenuous exercise until remission, at least 1 month.

Sources

Checked October 15, 2026.

Peripheral artery disease

What to say

Peripheral artery disease means narrowed leg arteries. It can cause calf, thigh or buttock pain with walking that eases with rest, and it raises heart attack and stroke risk.

A regular walking program, quitting smoking, and medicines for cholesterol, blood clots and blood pressure protect your legs and heart. Tell us soon about foot sores that won’t heal or leg pain at rest. Call 911 for a suddenly cold, pale, numb, weak or very painful leg.

Clinical reference

Before explaining

Confirm with resting ABI (≤0.90); TBI if >1.40. Start high-intensity statin, antiplatelet, BP/diabetes control, smoking cessation; refer for supervised exercise.

Warning signs

Acute limb ischemia (pain, pallor, pulselessness, paresthesia, paralysis, coolness): emergency. Rest pain, nonhealing wounds or gangrene: urgent vascular referral.

Follow-up

Reassess walking distance, foot exam and risk factors each visit. Persistent claudication: cilostazol (contraindicated in heart failure) or vascular referral.

Sources

Checked October 15, 2026.

Possible deep vein thrombosis

What to say

A new painful or swollen leg can be caused by a clot in a deep vein. We need prompt testing because a clot can travel to the lungs.

I’m arranging same-day assessment using your symptoms and risk factors to guide blood tests or ultrasound. We shouldn’t assume this is a muscle strain without checking.

Clinical reference

Before explaining

Use a validated diagnostic pathway; assess provoking factors, bleeding risk and need for interim treatment.

Warning signs

New breathlessness, chest pain, coughing blood or collapse means call 911.

Follow-up

Ensure same-day testing and any indicated repeat imaging or anticoagulation follow-up.

Sources

Checked September 24, 2026.

Postural tachycardia syndrome (POTS)

What to say

POTS means your heart rate jumps by 30 or more beats a minute when you stand, without a drop in blood pressure. Dizziness, a racing heart and tiredness are common, often after a viral illness such as COVID.

Drink 2–3 liters a day, add salt unless we advise otherwise, wear waist-high compression, and build up exercise slowly, starting seated, like a rowing machine or recumbent bike. Get urgent care if you faint and get hurt; call 911 for chest pain.

Clinical reference

Before explaining

Active stand test: sustained HR rise ≥30 bpm within 10 minutes, no orthostatic hypotension, symptoms ≥3 months; exclude anemia, hyperthyroidism, dehydration, drugs.

Warning signs

Exertional syncope, syncope with injury, chest pain or an abnormal ECG suggests another cause: urgent evaluation.

Follow-up

Reassess after nondrug measures; propranolol, midodrine, fludrocortisone or ivabradine are off-label options, often with specialist input.

Sources

Checked October 15, 2026.

Prediabetes

What to say

Your blood sugar is above the usual range but below the diabetes range. This raises future risk, but progression isn’t inevitable.

We can work on realistic food, activity and weight goals and consider a diabetes-prevention program. Some people also benefit from medicine, depending on their risk.

Clinical reference

Before explaining

Confirm glycemic category; assess cardiovascular risk, medications and factors affecting A1c reliability.

Warning signs

New marked thirst, frequent urination or unexplained weight loss warrants earlier glucose assessment.

Follow-up

Arrange repeat glycemic testing, generally at least annually, and review progress.

Sources

Checked September 24, 2026.

Raynaud phenomenon

What to say

In Raynaud, cold or stress narrows small arteries, so fingers or toes turn white or blue, then red as blood returns. It’s usually harmless, but sometimes it’s linked to another condition.

Keep your whole body warm, wear gloves, and don’t smoke or vape. Avoid decongestants like pseudoephedrine. Medicine can help if attacks are frequent. Get same-day care for a fingertip sore or a finger that stays white or blue after warming.

Clinical reference

Before explaining

Look for secondary features: onset after 30, one-sided, digital ulcers, rash, joint pain; check ANA and TSH; review vasoconstricting drugs.

Warning signs

Digital ulcers, or pallor, cyanosis or pain persisting after rewarming, suggests critical ischemia: same-day assessment.

Follow-up

Review attack frequency; consider nifedipine ER (off-label; no FDA-approved drug) for frequent attacks; refer to rheumatology if secondary features.

Sources

Checked October 15, 2026.

Stable coronary artery disease

What to say

Narrowing in the heart’s arteries can limit blood flow, especially during exertion. Treatment aims to reduce symptoms and lower heart-attack risk.

We’ll review preventive medicines, activity and your plan for chest discomfort. New, worsening or resting pain is a change from the stable pattern and needs urgent action.

Clinical reference

Before explaining

Confirm stability; review antianginal and preventive treatment, contraindications and rehabilitation needs.

Warning signs

New persistent chest pressure, pain at rest, breathlessness or sweating means call 911.

Follow-up

Review symptoms, exercise tolerance, risk factors and adherence.

Sources

Checked September 24, 2026.

Thyroid nodule

What to say

A thyroid nodule is a lump in the thyroid gland. Most are benign, but size, ultrasound appearance and thyroid function help us decide what to do.

We’ll arrange the appropriate blood test and ultrasound. Some nodules need a needle biopsy. Others can be monitored without a procedure.

Clinical reference

Before explaining

Assess compressive symptoms, radiation/family history, TSH and ultrasound risk features.

Warning signs

Rapid enlargement, new hoarseness or swallowing difficulty needs prompt review; breathing difficulty is urgent.

Follow-up

Track ultrasound/biopsy results and set a risk-based monitoring plan.

Sources

Checked September 24, 2026.

Varicose veins

What to say

These enlarged surface veins happen when blood doesn’t move back up the leg as efficiently. They can cause aching, heaviness or skin changes.

Regular movement and leg elevation may help. If symptoms, skin changes or ulcers develop, a vein specialist can discuss treatment. Compression needs an appropriate fit and circulation assessment.

Clinical reference

Before explaining

Assess skin, ulcers, prior clots and arterial disease before prescribing compression.

Warning signs

Bleeding needs firm pressure and elevation with urgent help if uncontrolled; new painful swelling needs clot assessment.

Follow-up

Review persistent symptoms, skin breakdown and referral needs.

Sources

Checked September 24, 2026.

Lungs & breathing

Acute bronchitis (chest cold)

What to say

Acute bronchitis, or a chest cold, is usually a virus that irritates the airways. The cough often lasts 2–3 weeks, and antibiotics don’t help.

Rest, fluids and honey in warm tea can make you more comfortable. Call us for fever lasting more than a few days, chest pain or a cough past 3 weeks. Get care the same day for shortness of breath or blood in your mucus, and call 911 for severe trouble breathing.

Clinical reference

Before explaining

Healthy, under 70, normal vitals and chest exam: pneumonia unlikely. Otherwise consider chest X-ray. Think asthma, COPD, pertussis, COVID, flu.

Warning signs

Breathlessness, chest pain, coughing blood, fever over 5 days or cough over 3 weeks needs reassessment for pneumonia or another cause.

Follow-up

Cough usually clears in 2–3 weeks; recheck if worsening or lasting longer. Advise smoking cessation; albuterol only if wheezing.

Sources

Checked October 15, 2026.

Asthma and the inhaler plan

What to say

Asthma makes the airways inflamed and sensitive, so they can narrow and cause cough, wheeze or tight breathing. We need a plan that treats that inflammation as well as one for symptoms when they happen.

Let’s put the inhalers in front of us and name exactly what each one does. Some plans use one inhaler for both regular treatment and extra relief. Others use separate inhalers. I’ll write the doses and daily limits, and I want to watch you use the device so we know the medicine reaches your lungs. If relief isn’t lasting, call the same day and follow the next steps in your written plan. Arrange a review if symptoms wake you at night. For severe breathlessness, trouble speaking or rescue medicine that isn’t helping as the plan says it should, call 911.

Clinical reference

  • Use an ICS-containing strategy; choose reliever/controller regimen based on age, severity, product and local guideline context.
  • For budesonide/formoterol SMART/MART, specify exact strength, maintenance/rescue doses and maximum total daily inhalations; do not extrapolate to other LABA combinations.

Before explaining

Assess symptoms, exacerbations, prior steroid courses, adherence, inhaler technique, triggers and access. Confirm diagnosis objectively when feasible. Distinguish asthma from COPD and other causes.

Warning signs

Acute severe symptoms require immediate triage/treatment. Repeated reliance on reliever or systemic steroids warrants reassessment of control and prevention.

Follow-up

Review after a treatment change, often within 1–3 months when stable; after an exacerbation, arrange earlier follow-up, commonly within 2–7 days for adults. Supply a written action plan.

Sources

Checked September 20, 2026.

COPD

What to say

COPD causes persistent airflow limitation and can make breathing harder. Treatment can improve daily function and reduce flare-ups.

We’ll confirm the diagnosis with breathing tests when appropriate and review inhaler technique, smoking treatment, vaccines and pulmonary rehabilitation. You should have a clear plan for worsening breathing.

Clinical reference

Before explaining

Confirm spirometry when stable; assess symptom burden, exacerbations, oxygen and inhaler suitability.

Warning signs

Severe breathlessness, blue/gray lips, confusion or inability to speak normally requires emergency care.

Follow-up

Review symptoms, activity, technique and exacerbations after treatment changes.

Sources

Checked September 24, 2026.

Coughing up blood

What to say

Coughing up blood has many causes, from bronchitis and other infections to less common problems such as a lung blood clot or lung cancer. Even a little blood needs a check.

We’ll ask about smoking, blood thinners and weight loss, and usually arrange a chest X-ray, sometimes a CT scan. Call 911 if you cough up more than a few teaspoons of blood, or any blood with chest pain, dizziness or trouble breathing.

Clinical reference

Before explaining

Chest X-ray first; CT for age 40 or older with heavy smoking, weight loss or an abnormal film. Check anticoagulants and TB risk.

Warning signs

More than a few teaspoons of blood, or any blood with chest pain, dizziness, fever or severe breathlessness, needs emergency care.

Follow-up

Even with a normal workup, high-risk patients need follow-up imaging and prompt review if bleeding recurs.

Sources

Checked October 15, 2026.

COVID-19

What to say

COVID can range from mild illness to serious disease. If you have risk factors for severe illness, treatment may lower the chance of hospitalization.

Contact us as soon as symptoms start because treatments have short starting windows. We’ll check all medicines and kidney function before choosing a treatment and discuss how to reduce spread.

Clinical reference

Before explaining

Assess onset, oxygen/severity, risk factors, drug interactions and renal/hepatic restrictions.

Warning signs

Severe breathlessness, persistent chest pain, confusion or inability to stay awake means emergency care.

Follow-up

Review worsening symptoms promptly and persistent symptoms after the acute illness.

Sources

Checked September 24, 2026.

Influenza

What to say

Flu is a viral respiratory infection that can cause sudden fever, aches and cough. Some people are at higher risk of serious illness.

Contact us promptly about antiviral treatment, particularly if you’re high risk or very ill. It works best when started early, but later treatment can still matter in severe or high-risk illness.

Clinical reference

Before explaining

Assess onset, severity, pregnancy, comorbidities and antiviral eligibility; do not delay indicated treatment for testing.

Warning signs

Trouble breathing, chest pain, confusion, dehydration or deterioration after initial improvement needs urgent care.

Follow-up

Give a clear reassessment plan for worsening or prolonged symptoms.

Sources

Checked September 24, 2026.

Latent TB infection (positive TB test)

What to say

A positive TB test usually means latent, or inactive, TB: the germs are asleep, so you’re not sick and can’t spread it. Without treatment, about 5–10 in 100 people later get active TB.

We’ll check for symptoms and get a chest X-ray to rule out active TB. Then 3–4 months of pills can lower your risk. Call us about a cough over 3 weeks, fever, night sweats, weight loss or coughing up blood.

Clinical reference

Before explaining

Exclude TB disease (symptoms, chest X-ray; sputum if indicated). Prior BCG: IGRA preferred. Review HIV, liver disease, alcohol, pregnancy, rifamycin interactions.

Warning signs

Higher progression risk: infection within 2 years, HIV, diabetes, kidney failure, TNF inhibitors or other immunosuppression. Hepatotoxicity: jaundice, dark urine, vomiting.

Follow-up

Prefer 3HP, 4R or 3HR; check adherence and symptoms monthly. Document completion; don’t repeat TB tests after a documented positive.

Sources

Checked October 15, 2026.

Obstructive sleep apnea

What to say

Sleep apnea causes repeated pauses or narrowing in breathing during sleep. It can lead to daytime sleepiness even after a full night in bed.

A sleep study can confirm it. Treatment may include a breathing device, an oral appliance or other changes depending on severity. Treating it can improve alertness and health.

Clinical reference

Before explaining

Assess snoring, witnessed pauses, sleepiness, cardiovascular risk and sedatives; arrange appropriate testing.

Warning signs

Do not drive or operate dangerous equipment when sleepy; severe breathing symptoms while awake need urgent assessment.

Follow-up

Review study results, treatment use and residual sleepiness.

Sources

Checked September 24, 2026.

Persistent cough

What to say

A cough can linger after an infection, but ongoing cough also has causes such as asthma, nasal drainage, reflux or medication effects.

We’ll look at duration, exposures and associated symptoms and decide whether a chest X-ray or breathing tests would help. Treatment works best when it targets the cause.

Clinical reference

Before explaining

Review smoking, ACE inhibitors, asthma, infection risk, hemoptysis and weight loss.

Warning signs

Coughing blood, chest pain or breathing difficulty needs urgent assessment; large-volume blood or severe distress is an emergency.

Follow-up

Review test results and response; investigate persistent unexplained cough.

Sources

Checked September 24, 2026.

Pneumonia

What to say

Pneumonia is an infection in the lungs. We first assess whether it’s safe to treat you at home or whether you need hospital support.

Take the prescribed treatment and allow time for recovery. Cough and tiredness may last longer than the fever, but worsening breathing or failure to improve needs review.

Clinical reference

Before explaining

Assess vitals, oxygen, severity, comorbidities and antibiotic choice; image when indicated.

Warning signs

Confusion, severe breathing difficulty, low oxygen or inability to maintain fluids needs urgent care.

Follow-up

Reassess if worsening or not improving within two to three days; arrange follow-up imaging only when indicated.

Sources

Checked September 24, 2026.

Shortness of breath

What to say

Breathlessness is a symptom with several possible causes, including heart, lung and blood problems. The speed of onset and severity tell us how urgently to investigate.

If it’s sudden or severe, we need urgent assessment rather than a routine follow-up. For stable ongoing symptoms, we’ll examine you and choose tests that fit the pattern.

Clinical reference

Before explaining

Assess oxygen, respiratory effort, cardiopulmonary findings, anemia and clot risk.

Warning signs

Inability to speak in sentences, blue/gray lips, chest pain, fainting or confusion means call 911.

Follow-up

Arrange cause-specific results review; give explicit instructions for any worsening.

Sources

Checked September 24, 2026.

Valley fever

What to say

Valley fever is a lung infection from a fungus in soil in parts of California and the Southwest. Breathing in the dust can cause cough, fever and tiredness 1–3 weeks later.

Most people get better without treatment, though tiredness can last for months. We’ll order a blood test and chest X-ray, and an antifungal medicine helps if you’re very sick or at higher risk. Get care right away for trouble breathing or a severe headache.

Clinical reference

Before explaining

Check dust exposure (Central Valley, Southwest); send cocci serology and chest X-ray. Fluconazole (off-label) for severe or high-risk disease; pregnancy needs its own plan.

Warning signs

Severe headache, skin wounds or ulcers, bone pain or worsening breathlessness may mean spread; urgent assessment, especially if immunosuppressed, diabetic, or Black or Filipino.

Follow-up

Plan regular follow-up, education and reconditioning until recovered; report to the local health officer within 7 days (Title 17).

Sources

Checked October 15, 2026.

Viral respiratory illness

What to say

Today’s findings fit a respiratory virus. An antibiotic wouldn’t shorten a viral illness and could give you diarrhea or another side effect. We can still treat what is making you miserable, whether that’s the cough, congestion, throat pain or aches.

It’s common for the cough to last longer than the other symptoms. What matters is the direction you’re heading. Call the same day for new breathing trouble, dehydration, returning fever or getting worse after initial improvement. For severe breathlessness, concerning chest pain, confusion or fainting, call 911. We’ve also checked whether flu or COVID treatment is appropriate for your timing and risk.

Clinical reference

  • Assess vitals, respiratory effort and lung findings; order testing only when it changes management.
  • Choose symptom care for the dominant problem. Assess influenza/COVID antiviral eligibility and interactions separately; no routine antibiotic for uncomplicated viral URI/bronchitis.

Before explaining

Review age, pregnancy, immunosuppression, cardiopulmonary disease and symptom onset. Do not use a viral script when the examination or trajectory raises pneumonia/other disease concern.

Warning signs

Hypoxemia, distress, confusion, major dehydration or concerning chest symptoms changes the setting. Reassess a worsening course rather than anchoring on the initial label.

Follow-up

Give a practical recheck point for the actual symptom duration and risk; earlier for worsening or returning fever. Persistent cough may need reassessment rather than repeated antibiotics.

Sources

Checked September 20, 2026.

Whooping cough (pertussis)

What to say

Whooping cough is a bacterial infection that causes coughing fits, sometimes with a whoop or vomiting afterward. It spreads easily, and the cough can last weeks to months.

Antibiotics started within 3 weeks of the cough help stop the spread. Stay home until you’ve taken them for 5 days. People you live with should get preventive antibiotics too, especially a baby or anyone pregnant. Call 911 for trouble breathing or blue lips.

Clinical reference

Before explaining

Treat within 3 weeks of cough onset (6 weeks if pregnant); macrolide preferred, TMP-SMX alternative. Reportable in California.

Warning signs

Breathing trouble, pneumonia or fainting with coughing fits; exposed infants face the highest risk of severe disease.

Follow-up

PEP for household and high-risk contacts within 21 days; check Tdap status. Lingering cough needs no more antibiotics.

Sources

Checked October 15, 2026.

Wildfire smoke and air quality

What to say

Wildfire smoke contains tiny particles that can harm your lungs and heart, especially if you’re older, pregnant or have lung or heart disease.

Check AirNow.gov for air quality. On smoky days, stay inside with windows closed and run a HEPA air cleaner or a box fan with a MERV 13 filter. If you must go out, wear a well-fitted N95. Keep your inhaler handy, and call 911 for chest pain or severe breathlessness.

Clinical reference

Before explaining

Identify asthma, COPD, heart disease or pregnancy; update action plans and rescue inhalers before smoke season.

Warning signs

Wheeze, worsening breathlessness, chest pain or palpitations during smoke events; smoke particles raise heart attack and stroke risk.

Follow-up

Review symptoms after smoke events; plan HEPA filtration, N95 fit and clean-air centers for high-risk patients.

Sources

Checked October 15, 2026.

Skin, hair & nails

Acne

What to say

Acne comes from blocked and inflamed hair follicles, not poor cleanliness. Treatment aims to reduce new spots and prevent scarring.

Use the plan consistently and gently. Harsh scrubbing can worsen irritation. Improvement takes weeks, and painful deep spots or scarring may need stronger treatment.

Clinical reference

Before explaining

Assess severity, scarring, mood impact, current products and pregnancy potential before selecting medicines.

Warning signs

Rapid severe worsening, major treatment reactions or significant emotional distress needs earlier review.

Follow-up

Review after a reasonable treatment trial, often eight to twelve weeks.

Sources

Checked September 24, 2026.

Actinic keratosis

What to say

These rough patches come from accumulated sun damage. Some can develop into skin cancer, so they deserve assessment and a treatment plan.

We can discuss freezing or a prescribed field treatment depending on the pattern. Sun protection and checking for changing lesions remain important afterward.

Clinical reference

Before explaining

Examine for invasive features; select treatment based on site, number and diagnostic confidence.

Warning signs

Rapid growth, tenderness, thickening, ulceration or bleeding needs prompt reassessment.

Follow-up

Review treatment clearance and new or changing lesions.

Sources

Checked September 24, 2026.

Alopecia areata

What to say

Alopecia areata is an autoimmune condition in which the immune system attacks hair follicles, causing smooth, round patches of hair loss. Hair often regrows, sometimes without treatment, but it can fall out again.

For small patches, options include steroid injections or creams. For widespread loss, a dermatologist can discuss prescription pills. It can be upsetting, so tell us how you’re coping; support groups can help.

Clinical reference

Before explaining

Confirm patchy non-scarring loss with exclamation-point hairs or nail pitting; consider thyroid testing and associated atopy, vitiligo or other autoimmune disease.

Warning signs

Pain, pustules, scarring or inflammation need assessment for another cause; rapid, extensive loss or marked distress needs dermatology and emotional support.

Follow-up

Limited patches: intralesional or topical steroid. Extensive: dermatology for JAK inhibitors (baricitinib, ritlecitinib, deuruxolitinib); NAAF for support.

Sources

Checked October 15, 2026.

Animal and human bites

What to say

Wash the bite right away with soap and running water. Cat, human, deep and hand bites infect easily, so we may prescribe antibiotics and update your tetanus shot.

Bat contact or bites from skunks, raccoons or foxes may need rabies shots; a healthy dog or cat can usually be watched for 10 days instead. In California, animal bites must be reported to animal control. Get care today for spreading redness, pus, fever, or hand swelling or stiffness.

Clinical reference

Before explaining

Assess depth, hand/face/joint involvement, edema, asplenia or immunosuppression. Tetanus if ≥5 years since last dose. Report to health officer/animal control (17 CCR §2606).

Warning signs

Bat contact or wild carnivore bite: same-day rabies PEP decision with public health. Clenched-fist injury or tenosynovitis signs: urgent hand surgery review.

Follow-up

Recheck high-risk wounds in 24–48 hours. Dog/cat: 10-day observation; start PEP if rabies signs appear. Human bites: assess HBV/HIV exposure.

Sources

Checked October 15, 2026.

Atopic eczema

What to say

Eczema makes the skin barrier dry and inflamed, causing itching and flares. Scratching can keep the cycle going.

Regular moisturizer helps maintain the barrier, and the prescribed anti-inflammatory treatment settles flares. I’ll show you which product goes where and for how long.

Clinical reference

Before explaining

Assess extent, infection, triggers and appropriate topical potency/site/duration.

Warning signs

Rapidly spreading painful blisters, fever or worsening infected-looking skin needs urgent assessment.

Follow-up

Review itch, sleep and flare control; reassess technique before escalating.

Sources

Checked September 24, 2026.

Bed bugs and lice

What to say

Bed bug bites itch, but bed bugs aren’t known to spread disease. A professional pest control company usually needs to treat the home. Meanwhile, wash bedding and clothes hot and dry them on the hottest setting.

Head lice don’t mean poor hygiene. Use a medicated lotion exactly as directed, comb out nits and repeat only as the label says. If you can’t wash clothes often, tell us; body lice need hot-washed clothes and sometimes medicine.

Clinical reference

Before explaining

Confirm by finding bed bugs, live lice or nits; bites alone are nonspecific. Ask about housing and laundry access.

Warning signs

Infected scratch sores, allergic reactions or lice persisting after proper treatment need review; body lice rarely carry trench fever.

Follow-up

Treat close contacts as advised and recheck after retreatment; renters should notify the landlord; help unhoused patients reach laundry and showers.

Sources

Checked October 15, 2026.

Cellulitis

What to say

Cellulitis is an infection in the skin and tissue underneath. It usually needs antibiotics and monitoring for spread.

Take the prescribed treatment and elevate the affected area when practical. We’ll check that pain and redness begin to settle. Worsening needs review rather than waiting to finish the course.

Clinical reference

Before explaining

Assess abscess, systemic illness, portals of entry and alternative diagnoses; document extent.

Warning signs

Rapid spread, severe pain out of proportion, blistering, confusion or marked illness needs emergency assessment.

Follow-up

Reassess if worsening or not improving within two to three days.

Sources

Checked September 24, 2026.

Changing mole or nonhealing lesion

What to say

A spot that changes, looks different from your others or won’t heal needs examination. Appearance alone can’t confirm whether it’s cancer.

We’ll assess it and arrange a biopsy or dermatology review when needed. Take changes seriously even if the spot is small or doesn’t hurt.

Clinical reference

Before explaining

Document evolution, asymmetry, border, color, size, bleeding and risk factors; assess pigmented and nonpigmented lesions.

Warning signs

Rapid change, repeated bleeding or a persistent nonhealing sore warrants prompt review.

Follow-up

Track referral/biopsy to a result and treatment plan.

Sources

Checked September 24, 2026.

Common warts

What to say

Common warts are caused by a skin virus. They may disappear on their own, though that can take time.

If they hurt or bother you, we can discuss salicylic-acid treatment or freezing. Treatment may take repeated attempts. Avoid picking or sharing files used on them.

Clinical reference

Before explaining

Confirm diagnosis; use caution with diabetes, poor circulation or reduced sensation. Genital/facial lesions need a different plan.

Warning signs

Bleeding, ulceration, unusual growth or diagnostic uncertainty warrants examination.

Follow-up

Review after an adequate treatment course or sooner for adverse skin injury.

Sources

Checked September 24, 2026.

Contact dermatitis

What to say

Your skin may be reacting to something touching it, either through irritation or allergy. Repeated exposure can keep the rash active.

We’ll review work, skin products and household exposures, then protect the skin and treat the inflammation. Persistent or unclear cases may benefit from allergy patch testing.

Clinical reference

Before explaining

Assess distribution, exposures and infection; choose site-appropriate topical treatment.

Warning signs

Blistering over a large area, facial swelling or infection needs prompt assessment; breathing difficulty is an emergency.

Follow-up

Review after avoiding suspected exposures; refer unresolved cases.

Sources

Checked September 24, 2026.

Cuts and minor wounds

What to say

Press with a clean cloth until bleeding stops. Wash gently with soap and water, then apply petroleum jelly and a bandage, changed daily. Check whether your tetanus shot is due.

Get same-day care if a cut gapes, is over a quarter inch deep, is on your face or has something stuck in it, or for spreading redness, pus or fever. Go to urgent care or the emergency department if bleeding won’t stop after 10 minutes of firm pressure, or if the area is numb or won’t move. Call 911 for heavy, spurting bleeding.

Clinical reference

Before explaining

Assess depth, neurovascular and tendon function, and foreign bodies. Irrigate; close gaping wounds with glue, strips or sutures.

Warning signs

Spreading erythema, purulence, fever or lymphangitis suggests infection. Bites, deep punctures and retained debris need separate assessment.

Follow-up

Tetanus vaccine if last dose ≥10 years (clean minor) or ≥5 years (other wounds), or series incomplete/unknown. TIG for dirty wounds if series incomplete/unknown, HIV or severe immunodeficiency.

Sources

Checked October 15, 2026.

Epidermoid cyst and lipoma

What to say

An epidermoid cyst is a firm bump, often with a small central pore and cheesy contents. A lipoma is a soft, rubbery lump of fat. Both are usually harmless.

Don’t squeeze a cyst. Warm compresses help an inflamed one; we can drain an abscess and remove the cyst later. Lipomas need removal only if bothersome. Call the same day for spreading redness or fever, and soon for a lump that grows, hardens or hurts.

Clinical reference

Before explaining

Ultrasound an unexplained enlarging lump to assess for sarcoma; also image lumps that are hard, fixed or painful.

Warning signs

Inflamed cyst with cellulitis or fever: drain if fluctuant and treat infection. Refer if imaging is suspicious or uncertain.

Follow-up

Excise a cyst once inflammation settles; incomplete removal can recur. Remove lipomas only if symptomatic or the diagnosis is uncertain.

Sources

Checked October 15, 2026.

Excessive sweating

What to say

Excessive sweating (hyperhidrosis) means sweating more than your body needs to cool down. It often affects the underarms, palms or soles and tends to run in families.

A strong antiperspirant at bedtime is the usual first step; prescription underarm wipes, a hand-and-foot water device, Botox injections or pills are next options. Tell us if sweating is new, mostly at night, or comes with fever, weight loss, palpitations or chest pain.

Clinical reference

Before explaining

Primary: focal, familial. Secondary: sudden onset, generalized or nocturnal; review medicines, thyroid, glucose, infection, menopause and anxiety.

Warning signs

Night sweats, fever, weight loss, palpitations or chest pain suggest a secondary cause; chest pain needs emergency care.

Follow-up

If antiperspirants fail after a few weeks, add glycopyrronium cloth (underarms), iontophoresis, botulinum toxin or oral anticholinergics; refer to dermatology.

Sources

Checked October 15, 2026.

Folliculitis

What to say

Folliculitis means irritated or infected hair follicles, which look like small red bumps or pimples. Shaving, friction from tight clothes and hot tubs are common triggers.

Use warm compresses, keep the area clean, and avoid shaving and tight clothing. We may add a skin antibiotic or antifungal. Call us if it worsens, lasts more than 2 to 3 days, keeps coming back, or you get boils, spreading redness or fever.

Clinical reference

Before explaining

Ask about shaving, friction, hot tub exposure and occlusion; culture if recurrent, spreading or not improving, and consider fungal causes.

Warning signs

Boils or abscess, spreading redness, fever or swollen nodes suggest deeper infection and need prompt assessment.

Follow-up

Reassess if not improving within a few days; for recurrence, culture and consider decolonization as for recurrent boils.

Sources

Checked October 15, 2026.

Fungal nail infection

What to say

Thick or discolored nails can be fungal, but injury and other skin conditions can look similar.

Before oral treatment, we should confirm fungus with a nail sample. Treatments take time, and the nail looks better only as healthy nail grows out. Observation is reasonable if symptoms are minor.

Clinical reference

Before explaining

Confirm diagnosis; review liver disease, interactions and monitoring before systemic therapy.

Warning signs

Painful redness, drainage or a wound, especially with diabetes, needs prompt review.

Follow-up

Review test results and treatment tolerance; judge regrowth over months.

Sources

Checked September 24, 2026.

Hair loss

What to say

Hair loss can follow illness or stress, occur in a patterned way, or reflect inflammation or another condition. The pattern and timing help identify the cause.

We’ll examine the scalp, review medicines and decide whether targeted blood tests or dermatology assessment are useful. Treatment depends on the cause, and visible regrowth takes time.

Clinical reference

Before explaining

Assess diffuse/patchy/scarring pattern, nutrition, endocrine clues and medication history.

Warning signs

Pain, pustules or signs of scarring need prompt dermatology assessment.

Follow-up

Review test results and progression; document response over months.

Sources

Checked September 24, 2026.

Hidradenitis suppurativa

What to say

This condition causes recurring inflamed lumps, often in the armpits or groin. It can form tunnels and scars and isn’t caused by poor hygiene.

Early ongoing treatment can reduce flares and scarring. We can discuss medicines, wound care and dermatology support rather than treating each lump as an isolated boil.

Clinical reference

Before explaining

Assess sites, tunnels/scars, pain, mental health and severity; discuss modifiable factors without blame.

Warning signs

Fever or rapidly spreading redness may indicate secondary infection and needs prompt assessment.

Follow-up

Review flare frequency, pain, drainage and specialist treatment access.

Sources

Checked September 24, 2026.

Hives

What to say

Hives are raised, itchy welts that can move around or disappear and reappear. They aren’t always caused by an allergy, especially when they persist.

An appropriate antihistamine can reduce itching. We’ll look for likely triggers and review persistent episodes rather than ordering broad allergy tests without a useful clue.

Clinical reference

Before explaining

Assess angioedema, drug/exposure timing, duration and systemic features.

Warning signs

Tongue/throat swelling, trouble breathing or faintness means call 911 and use prescribed epinephrine if available.

Follow-up

Review persistent/recurrent hives or lesions that bruise or remain fixed.

Sources

Checked September 24, 2026.

Impetigo

What to say

Impetigo is a contagious skin infection caused by bacteria. Sores ooze, then form honey-colored crusts, often on exposed skin like the face.

Gently wash off crusts with soap and water before applying antibiotic ointment; with many sores, you may need pills instead. Cover sores, wash your hands and don’t share towels. You can return to work once treatment has started and sores are covered. Call us if it spreads or you get a fever.

Clinical reference

Before explaining

Limited lesions: mupirocin or retapamulin twice daily for 5 days. Numerous lesions or outbreaks: oral therapy for 7 days (IDSA).

Warning signs

Usually MSSA: cephalexin or dicloxacillin; suspected MRSA: doxycycline, clindamycin or TMP-SMX. Ecthyma needs oral therapy; fever or cellulitis needs review.

Follow-up

Review if not improving within a few days; culture if failing. Recurrent infection: culture and consider staph decolonization.

Sources

Checked October 15, 2026.

Ingrown toenail

What to say

The edge of the nail is pressing into the surrounding skin, causing pain and sometimes infection.

Wear roomy shoes and avoid digging into the corner. If it persists or recurs, a podiatry procedure can remove the troublesome edge and sometimes prevent it growing back.

Clinical reference

Before explaining

Assess infection, circulation, diabetes and neuropathy before self-care advice.

Warning signs

Spreading redness, pus, fever or a wound in someone with diabetes needs prompt assessment.

Follow-up

Review healing; refer persistent or recurrent cases.

Sources

Checked September 24, 2026.

Intertrigo

What to say

Intertrigo is a red, sore rash in skin folds, such as the groin, armpits or under the breasts, caused by friction and moisture. Yeast or bacteria often join in.

Keep folds dry: separate them with a clean cloth, wear loose breathable clothing and use a barrier cream. We may add an antifungal cream and a short course of mild steroid. Call us for oozing, a bad smell, spreading redness or fever.

Clinical reference

Before explaining

Look for candidiasis, erythrasma, tinea or impetigo; consider obesity, diabetes, hyperhidrosis, friction and occlusive devices.

Warning signs

Foul odor, oozing, pustules, fever or spread beyond the fold suggests bacterial infection and needs prompt review.

Follow-up

Reassess if not clearing with good home care; for recurrence, address moisture, weight and glucose control.

Sources

Checked October 15, 2026.

Lyme disease and tick bites

What to say

Remove a tick with fine-tipped tweezers: grasp it close to the skin and pull with steady pressure, without twisting. Then clean the area. Most tick bites don’t cause Lyme disease.

Antibiotics to prevent Lyme help only after certain high-risk bites. Over the next month, call us for an expanding rash, fever or aches. Facial drooping, palpitations or joint swelling, even later, also need prompt care. Repellent and tick checks prevent bites.

Clinical reference

Before explaining

High-risk bite: Ixodes tick, highly endemic area and attachment ≥36 hours (engorged). Then doxycycline 200 mg once within 72 hours of removal.

Warning signs

Erythema migrans is a clinical diagnosis; treat without serology (doxycycline 10 days). Facial palsy, carditis or arthritis needs evaluation.

Follow-up

Highly endemic (IDSA): Northeast, mid-Atlantic, north-central US. CDPH lists the Bay Area as a risk area; about 1 in 3 California cases are acquired out of state.

Sources

Checked October 15, 2026.

Minor burns

What to say

For a small burn, run cool (not ice) water over it for 10 to 20 minutes and remove rings before it swells. Cover with petroleum jelly and a nonstick bandage. Don’t pop blisters; acetaminophen or ibuprofen helps pain.

Go to the emergency department for burns larger than your palm, on the face, hands, feet, genitals or a joint, white or numb, or from chemicals, electricity or smoke. Call us for pus, fever, spreading redness or pain beyond 2 days.

Clinical reference

Before explaining

Estimate depth and size; note face, hands, feet, genitals, joints, chemical or electrical cause, inhalation and abuse concern; check tetanus status.

Warning signs

Pus, fever, spreading redness, increasing pain, dehydration or airway symptoms need prompt assessment; deep, white or numb burns need emergency care.

Follow-up

Review pain, blisters and infection signs; pain beyond 48 hours or healing slower than about 2 weeks needs reassessment.

Sources

Checked October 15, 2026.

Paronychia

What to say

Paronychia is an infection of the skin around a fingernail or toenail. It causes a red, swollen, painful nail fold, sometimes with pus, and often follows nail biting, a hangnail or frequent wet work.

Soak the area in warm water several times a day. If pus collects, we may drain it, and some infections need antibiotics. Call the same day for spreading redness, red streaks or fever, especially with diabetes.

Clinical reference

Before explaining

Look for fluctuance or abscess, felon, cellulitis, herpetic whitlow, diabetes, immunosuppression and chronic wet-work or nail-biting exposure.

Warning signs

Red streaks, fever, spreading cellulitis or a tense, painful fingertip need same-day assessment; diabetes or immunosuppression lowers the threshold.

Follow-up

Reassess if not improving after soaks or drainage. Chronic (6+ weeks): avoid moisture and irritants, cotton-lined gloves, topical steroid or antifungal.

Sources

Checked October 15, 2026.

Psoriasis

What to say

Psoriasis causes the immune system to speed up skin turnover, producing inflamed, scaly areas. It isn’t contagious.

We can treat the skin with creams or other therapies depending on severity. Tell me about swollen joints, heel pain or prolonged morning stiffness because psoriasis can affect joints too.

Clinical reference

Before explaining

Assess extent, nails, joint symptoms, mood and cardiometabolic risks.

Warning signs

Widespread redness/pustules with systemic illness needs urgent assessment; new inflammatory joint symptoms need timely review.

Follow-up

Review skin response and screen for joint involvement.

Sources

Checked September 24, 2026.

Recurrent boils and MRSA

What to say

Boils are usually staph infections of a hair follicle, and some people get them repeatedly. A large boil often needs a clinician to drain it; please don’t pick, squeeze or pop it.

For repeat boils we may culture the pus for MRSA, a staph that resists many antibiotics, and suggest a 5-day nose ointment and chlorhexidine wash routine with towels and sheets washed daily. Don’t share towels or razors. Call us for fever, spreading redness or severe pain.

Clinical reference

Before explaining

Drain and culture early; look for local causes such as hidradenitis suppurativa, pilonidal cyst or foreign material; consider decolonization.

Warning signs

Fever or other systemic signs, multiple abscesses, rapid spread or immune compromise need prompt assessment and consideration of antibiotics.

Follow-up

Review culture results. Decolonization has weak, low-quality evidence; consider including household contacts if used.

Sources

Checked October 15, 2026.

Ringworm and athlete’s foot

What to say

This appears to be a fungal skin infection. Despite the name, ringworm is caused by a fungus, not a worm.

Use the antifungal for the full recommended course, keep the area dry and avoid sharing towels. A steroid cream alone can hide or worsen fungal infection.

Clinical reference

Before explaining

Confirm distribution; consider scraping if uncertain and assess scalp/nail involvement, diabetes and immune status.

Warning signs

Spreading painful redness, fever or a diabetic foot wound needs prompt care.

Follow-up

Reassess if not clearing, recurrent or involving scalp/nails.

Sources

Checked September 24, 2026.

Rosacea

What to say

Rosacea can cause facial flushing, sensitivity and acne-like bumps. It often comes and goes and can affect the eyes too.

Gentle skin care, sun protection and identifying your own triggers can help. We can choose a topical or oral treatment based on the main symptoms.

Clinical reference

Before explaining

Assess skin and ocular symptoms; distinguish acne, dermatitis and medication effects.

Warning signs

Eye pain, light sensitivity or blurred vision needs urgent eye assessment.

Follow-up

Review skin response and irritation after the treatment trial.

Sources

Checked September 24, 2026.

Scabies

What to say

Scabies is caused by tiny mites in the skin and can produce intense itching. It spreads through close contact and isn’t a sign of poor hygiene.

Treatment needs careful whole-area application as directed, with close contacts treated together. We’ll explain laundering and repeat treatment. Itching may continue for a few weeks after successful treatment.

Clinical reference

Before explaining

Confirm pattern and contact history; assess crusted scabies, immune status and pregnancy.

Warning signs

Spreading infection, extensive crusting or persistent new burrows needs reassessment.

Follow-up

Review new lesions and completion of contact treatment; distinguish residual itch from reinfestation.

Sources

Checked September 24, 2026.

Seborrheic dermatitis

What to say

Seborrheic dermatitis causes flaky, greasy, itchy patches on the scalp, eyebrows, sides of the nose and ears. It’s linked to normal skin yeast and often flares with stress or weather changes.

Use a dandruff shampoo with ketoconazole, selenium or zinc, leaving the lather on a few minutes. For the face, an antifungal cream or a short course of mild steroid cream helps. It tends to return, so keep using the shampoo about once a week.

Clinical reference

Before explaining

Distinguish psoriasis, rosacea, tinea and contact dermatitis. Severe or sudden widespread disease: consider HIV or neurologic disease such as Parkinson disease.

Warning signs

Keep facial steroids to short courses (atrophy, perioral dermatitis). Failure of treatment suggests another diagnosis.

Follow-up

Maintenance shampoo about weekly. Refractory: roflumilast 0.3% foam (FDA-approved, age ≥9) or short-term topical calcineurin inhibitors (off-label).

Sources

Checked October 15, 2026.

Seborrheic keratoses and skin tags

What to say

Seborrheic keratoses are waxy, “stuck-on” tan or brown growths that often appear from middle age. Skin tags are small, soft flaps of skin. Both are common and harmless.

Removal is optional, usually by freezing or snipping, and insurance may not cover it if done for appearance. Don’t cut them off yourself. Show us any spot that changes quickly, bleeds, or looks different from your others.

Clinical reference

Before explaining

Biopsy a lesion that is atypical, solitary, irregular in border or color, or an ‘ugly duckling’ among the others.

Warning signs

Rapid change, bleeding or ulceration, or a sudden eruption of many seborrheic keratoses, needs prompt review.

Follow-up

Removal (cryotherapy, shave or snip) is optional; note irritation or bleeding if relevant to coverage.

Sources

Checked October 15, 2026.

Shingles

What to say

Shingles is a reactivation of the chickenpox virus, usually causing pain and blisters on one side of the body.

Contact us promptly because antiviral treatment works best early. Keep the rash covered and avoid exposing susceptible pregnant people, newborns and immunocompromised people until lesions crust.

Clinical reference

Before explaining

Assess onset, immune status, eye/ear involvement and pain; treatment may still be indicated with ongoing lesions or complications.

Warning signs

Rash near the eye, visual symptoms, facial weakness or widespread illness needs urgent assessment.

Follow-up

Review pain and healing; address persistent nerve pain.

Sources

Checked September 24, 2026.

Skin abscess

What to say

An abscess is a pocket of pus under the skin. It often needs drainage. Antibiotics alone may not empty the pocket.

We’ll assess whether drainage is needed and whether antibiotics should be added. Don’t squeeze or cut it yourself, and follow the dressing instructions afterward.

Clinical reference

Before explaining

Assess size, location, cellulitis, systemic illness and immune status; culture when indicated.

Warning signs

Fever, rapidly spreading redness or severe pain needs urgent review.

Follow-up

Arrange wound review and reassess recurrent abscesses.

Sources

Checked September 24, 2026.

Tinea versicolor

What to say

Tinea versicolor is a harmless yeast overgrowth that causes light or dark, slightly scaly patches, usually on the chest and back. It doesn’t spread from person to person.

We’ll treat it with an antifungal shampoo or lotion on the skin, or pills if it’s widespread. Color can take weeks to months to even out, and it often returns in warm, humid weather, so an occasional preventive wash helps.

Clinical reference

Before explaining

Usually a clinical diagnosis; use KOH microscopy or Wood lamp if uncertain, and consider vitiligo or seborrheic dermatitis.

Warning signs

Extensive, thick or repeatedly recurring patches may need oral antifungal treatment or dermatology review.

Follow-up

Reassess if patches persist after treatment; color change lags behind clearing. Consider monthly preventive washes in warm months.

Sources

Checked October 15, 2026.

Venous leg ulcer and stasis dermatitis

What to say

When leg veins don’t return blood well, fluid pools near the ankles. The skin can become itchy, swollen and brownish, and sores called venous ulcers can form.

Compression stockings or wraps, raising your legs above your heart, daily walking and moisturizer are the main treatments. We’ll check your leg arteries before compression. Avoid antibiotic or numbing creams, which can make it worse. Call the same day for spreading redness, increasing pain, pus or fever.

Clinical reference

Before explaining

Check pulses and ABI before compression. Consider arterial, neuropathic or malignant causes if an ulcer is atypical or not healing.

Warning signs

Avoid topical neomycin, lanolin and benzocaine, which worsen stasis dermatitis. Cellulitis or fever needs same-day assessment.

Follow-up

Topical steroid for dermatitis flares; regular wound and compression review. Refer nonhealing ulcers for vascular or wound care.

Sources

Checked October 15, 2026.

Ears, nose, throat & eyes

Acute otitis media

What to say

An infection behind the eardrum can cause pain and muffled hearing. We need an ear examination to distinguish it from canal infection or fluid alone.

We’ll manage pain and decide whether an antibiotic is appropriate for your findings and severity. Persistent symptoms need another look.

Clinical reference

Before explaining

Confirm middle-ear findings on otoscopy; assess systemic illness, complications, allergy and recent antibiotics. Persistent unilateral effusion in an adult warrants evaluation.

Warning signs

Swelling behind the ear, severe headache, facial weakness or systemic deterioration needs urgent care.

Follow-up

Reassess worsening or persistent symptoms; evaluate unresolved adult unilateral effusion.

Sources

Checked September 24, 2026.

Acute sinus symptoms

What to say

Sinus pressure and colored mucus can happen with a virus, so those findings alone don’t tell us that an antibiotic will help. The timeline is more useful: symptoms that keep going without improvement or worsen again after initial improvement make a bacterial infection more likely.

We can treat the congestion and pressure while we watch the course, provided we agree on when to check back. If we choose an antibiotic, it will be a short course with a reassessment plan. For saline rinses, use distilled or sterile water. Ask for written instructions if you need to boil and cool tap water safely. For swelling around an eye with vision changes, painful eye movement or a severe unusual headache, go to the emergency department.

Clinical reference

  • 2025 AAO-HNS ABRS criteria: compatible symptoms ≥10 days without improvement or double worsening. Offer watchful waiting when follow-up is reliable.
  • If antibiotics are chosen, amoxicillin with or without clavulanate for 5–7 days is first-line for most adults; choose alternatives based on allergy, risk and local guidance.
  • Adult ABRS criteria include purulent nasal drainage with obstruction and/or facial pain/pressure persisting ≥10 days without improvement, or worsening after initial improvement. Assess severe presentations and complications separately.

Before explaining

Assess orbital/neurologic complications, systemic illness, immunocompromise, dental source and persistent unilateral symptoms. Severe illness should not wait until day ten.

Warning signs

Orbital symptoms, visual changes, neurologic signs or severe systemic illness need urgent/emergency assessment rather than outpatient observation.

Follow-up

Reassess observation or antibiotic nonresponse over about 3–5 days, sooner if worse. Routine sinus imaging is not indicated for uncomplicated acute disease.

Sources

Checked September 20, 2026.

Allergic rhinitis

What to say

Sneezing, itching and a runny or blocked nose can be caused by an allergic response to pollen, dust or other triggers.

We can reduce exposure where practical and choose an antihistamine or nasal steroid. Correct spray technique and regular use matter. Nasal rinses need distilled, sterile or previously boiled and cooled water.

Clinical reference

Before explaining

Assess triggers, asthma, unilateral symptoms and current sprays; avoid prolonged decongestant use.

Warning signs

Worsening wheeze, significant breathing difficulty or facial/eye swelling needs urgent assessment.

Follow-up

Review control, sleep and spray technique.

Sources

Checked September 24, 2026.

Benign positional vertigo

What to say

Brief spinning triggered by particular head movements can happen when tiny inner-ear particles move into the wrong place.

If the examination confirms this, a repositioning maneuver can often help. We’ll check which side is affected and whether your neck allows the maneuver safely. Avoid driving while dizzy.

Clinical reference

Before explaining

Confirm positional findings and examine for neurologic/central causes before reassuring.

Warning signs

New weakness, double vision, speech trouble, inability to walk or severe headache needs emergency assessment.

Follow-up

Reassess persistent or atypical dizziness; repeat treatment or refer as needed.

Sources

Checked September 24, 2026.

Blepharitis

What to say

The edges of your eyelids are inflamed, often causing crusting, irritation or gritty eyes. It commonly needs ongoing care rather than a one-time cure.

Warm compresses and gentle lid cleaning can help loosen debris. If that isn’t enough, we can discuss additional treatment and check for dry eye or rosacea.

Clinical reference

Before explaining

Assess lid margins, cornea, contact lenses and recurrent focal lesions.

Warning signs

Pain inside the eye, reduced vision or marked swelling needs urgent assessment.

Follow-up

Review persistent symptoms and cleaning technique.

Sources

Checked September 24, 2026.

Blood spot on the eye (subconjunctival hemorrhage)

What to say

A bright red patch on the white of your eye is usually a small broken blood vessel. Coughing, straining, rubbing or blood thinners can cause it, and it doesn’t hurt or affect vision.

It fades in about 2–3 weeks and may turn yellow as it heals. Artificial tears can ease irritation, and we’ll check your blood pressure. Get a same-day eye exam for pain, vision changes, light sensitivity or an eye injury.

Clinical reference

Before explaining

Check BP and anticoagulant or antiplatelet use (INR if on warfarin); look for trauma, pain or reduced vision.

Warning signs

Pain, photophobia, reduced vision, hyphema or trauma (possible globe injury) need same-day ophthalmology.

Follow-up

Recurrent episodes or other bleeding: check CBC and coagulation studies; recheck BP.

Sources

Checked October 15, 2026.

Conjunctivitis

What to say

Inflammation of the eye’s surface can be viral, bacterial or allergic. The cause affects whether an antibiotic will help.

Keep hands clean, avoid sharing towels and stop wearing contact lenses while the eye is affected. We’ll choose treatment after checking for features of a more serious eye problem.

Clinical reference

Before explaining

Assess vision, pain, photophobia and contact-lens use; do not label every red eye conjunctivitis.

Warning signs

Eye pain, light sensitivity or reduced vision needs urgent eye assessment; a red eye in a contact-lens wearer needs prompt review.

Follow-up

Reassess worsening or persistent symptoms.

Sources

Checked September 24, 2026.

Dental pain or abscess

What to say

Tooth pain or a gum abscess usually comes from decay or infection around a tooth. Only a dentist can treat the cause, so book a dental visit soon.

If it’s safe for you, ibuprofen plus acetaminophen eases pain better than opioids. Antibiotics help only if the infection spreads or you have a fever. Go to the emergency department for spreading face or neck swelling, swelling near the eye, or trouble swallowing or breathing.

Clinical reference

Before explaining

Screen for NSAID contraindications (kidney disease, ulcers, anticoagulants). Arrange dental care; offer low-cost dental clinics if cost is a barrier.

Warning signs

Spreading face, neck or eye swelling, trouble swallowing or breathing, or trismus needs emergency care; fever or malaise needs same-day assessment.

Follow-up

Confirm dental treatment occurred. Antibiotics only with systemic signs (fever, malaise); opioids only if NSAIDs fail or can’t be used.

Sources

Checked October 15, 2026.

Dry eyes

What to say

Dry eyes can feel gritty, burning or even excessively watery because the tear film isn’t protecting the surface well.

Lubricating drops, regular screen breaks and reducing drying airflow may help. We’ll review medicines and eyelid problems if symptoms continue.

Clinical reference

Before explaining

Assess contact lenses, medications, lid disease, systemic dryness and visual symptoms.

Warning signs

A painful red eye, light sensitivity or reduced vision needs urgent assessment.

Follow-up

Review response and arrange eye assessment for persistent symptoms.

Sources

Checked September 24, 2026.

Ear pressure and blocked ears

What to say

A blocked or full feeling in your ears often means the small tube that balances pressure behind the eardrum isn’t opening well. Colds, allergies and flying are common triggers.

Swallowing, yawning or gently blowing with your nose pinched can help. A steroid nose spray helps if allergies are involved. Most cases clear on their own, but sudden hearing loss in one ear needs same-day care.

Clinical reference

Before explaining

Check eardrums for effusion or retraction and ask about colds, allergies and flights. Persistent one-sided effusion in adults needs nasopharynx evaluation.

Warning signs

Sudden hearing loss needs same-day evaluation; ear pain with fever or drainage, severe vertigo or new weakness needs prompt assessment.

Follow-up

Recheck if still blocked after about 3 months, or sooner if hearing drops; consider ENT referral and audiometry.

Sources

Checked October 15, 2026.

Earwax blockage

What to say

Wax is protective, but a buildup can block hearing or cause fullness. We should check the ear before assuming wax explains a sudden hearing change.

Don’t push objects into the canal. We can discuss suitable softening drops or professional removal based on the eardrum and your ear history.

Clinical reference

Before explaining

Assess perforation, tubes, prior surgery, pain and true sudden hearing loss before removal.

Warning signs

Sudden hearing loss, significant pain or discharge needs prompt assessment.

Follow-up

Confirm hearing improves after removal; investigate persistent hearing loss.

Sources

Checked September 24, 2026.

Hearing loss

What to say

Hearing loss can come from blockage, middle-ear problems or changes in the inner ear. The timing matters, especially if it happened suddenly.

We’ll examine your ears and arrange hearing testing. Hearing aids or other treatment can help depending on the cause. Sudden loss needs urgent assessment rather than routine testing.

Clinical reference

Before explaining

Assess onset, asymmetry, noise, medications, otoscopy and neurologic signs.

Warning signs

Sudden hearing loss requires same-day urgent evaluation; associated weakness or other stroke signs means emergency care.

Follow-up

Track audiology/ENT results and communication support.

Sources

Checked September 24, 2026.

Loss of smell

What to say

Smell loss most often follows a cold, COVID-19 or sinus swelling, but nasal polyps, head injury, medicines and aging can also cause it. Recovery can take months.

We’ll check your nose and may refer you to an ear, nose and throat specialist. Sniffing rose, lemon, clove and eucalyptus scents daily can help retrain smell. Use working smoke and gas detectors, and call 911 if smell loss comes with sudden weakness or trouble speaking.

Clinical reference

Before explaining

Ask about viral illness, sinus disease, head injury, medicines and neurologic symptoms; look for polyps. ENT referral if persistent.

Warning signs

Smell loss with sudden weakness, speech trouble or confusion needs emergency care; with tremor or memory change, neurologic review.

Follow-up

Smell training once or twice daily for months; nasal steroid for polyps or sinus disease; safety detectors and food dates.

Sources

Checked October 15, 2026.

Mononucleosis

What to say

Mono is a viral infection, usually from Epstein-Barr virus, that causes sore throat, fever, swollen glands and tiredness. Most people improve in 2–4 weeks, but fatigue can last months.

Rest, drink fluids and use acetaminophen or ibuprofen for pain. Your spleen may swell, so avoid contact sports and heavy lifting for at least 4 weeks and until you’ve fully recovered. Get emergency care for sudden severe belly pain or trouble breathing or swallowing.

Clinical reference

Before explaining

Confirm with monospot or EBV serology; consider strep and acute HIV. Avoid amoxicillin or ampicillin (rash).

Warning signs

Splenic rupture (sudden LUQ or left shoulder pain) and airway obstruction; reserve steroids for threatened airway or severe disease.

Follow-up

Review if not improving by 2–4 weeks; clear return to contact sports only after full recovery.

Sources

Checked October 15, 2026.

Mouth ulcers

What to say

Most mouth ulcers are canker sores. They’re painful but harmless, aren’t contagious, and usually heal on their own in 1–2 weeks.

Avoid spicy, salty or acidic foods and toothpaste with sodium lauryl sulfate, and ask us about numbing gels or a steroid mouth medicine. Call us if an ulcer lasts more than 3 weeks or keeps coming back, and get same-day care if you can’t drink or swallow.

Clinical reference

Before explaining

Distinguish aphthous ulcers from herpes, lichen planus and cancer. With frequent ulcers check CBC, ferritin, B12, folate and celiac serology.

Warning signs

Ulcer over 3 weeks or a white or red patch (especially in smokers) needs biopsy referral; dehydration or trouble swallowing is urgent.

Follow-up

Recheck by 3 weeks if unhealed; for recurrent or severe ulcers, consider IBD, celiac disease or immune conditions.

Sources

Checked October 15, 2026.

New floaters or flashes

What to say

New floaters or flashes usually mean the gel inside the eye is pulling away from the retina, the light-sensing layer at the back. This is common with age and usually harmless, but it can tear the retina.

You need a dilated eye exam today. If an eye doctor can’t see you today, or you notice a dark curtain or shadow or lose vision, go to the emergency department now.

Clinical reference

Before explaining

Ask about curtain/shadow, vision loss, high myopia, prior eye surgery, injury or retinal detachment. Check acuity and fields; arrange same-day dilated exam.

Warning signs

Curtain, field loss or reduced acuity suggests retinal detachment: emergency. Sudden painless monocular vision loss may be retinal artery occlusion: stroke pathway.

Follow-up

Confirm the exam happened and its plan. New floaters, flashes or shadow after a normal exam need prompt re-examination.

Sources

Checked October 15, 2026.

Nosebleeds

What to say

Most nosebleeds start near the front of the nose. Sit upright, lean forward and pinch the soft part firmly for ten to fifteen minutes without checking repeatedly.

Breathe through your mouth and spit out blood rather than swallowing it. Once it stops, avoid picking, forceful blowing and heavy exertion for the next day.

Clinical reference

Before explaining

Assess bleeding severity, trauma, anticoagulants and recurrent episodes; do not independently stop prescribed anticoagulation.

Warning signs

Bleeding that continues after sustained pressure, heavy bleeding, weakness or breathing difficulty needs urgent care.

Follow-up

Review recurrent episodes and underlying contributors.

Sources

Checked September 24, 2026.

Otitis externa

What to say

The skin of the ear canal is inflamed or infected. Keep it dry and avoid putting cotton swabs or other objects inside.

The prescribed drops treat the canal. We’ll show you how to use them. Tell us if symptoms worsen or aren’t beginning to improve.

Clinical reference

Before explaining

Examine canal/eardrum; select drops safe for possible perforation; assess diabetes/immunosuppression.

Warning signs

Severe persistent pain, spreading redness or fever needs urgent review, especially with diabetes.

Follow-up

Reassess nonresponse within 48–72 hours.

Sources

Checked September 24, 2026.

Persistent hoarseness

What to say

Hoarseness is a rough, strained or weak voice, often from a cold, overuse or reflux. Most cases improve within a few weeks.

Rest your voice, avoid whispering, sip water and don’t smoke. If it lasts more than 4 weeks, we’ll arrange a camera exam of your vocal cords, sooner if you smoke. Get same-day care for coughing up blood, trouble swallowing or noisy breathing; call 911 if you’re struggling to breathe.

Clinical reference

Before explaining

Laryngoscopy if not resolved in 4 weeks, or sooner with tobacco use, neck mass, recent neck/chest surgery or intubation.

Warning signs

Stridor or respiratory distress is an emergency; hemoptysis, dysphagia, ear pain or weight loss raise concern for cancer.

Follow-up

Avoid routine antibiotics; no steroids or empiric PPIs before laryngoscopy. Track voice outcome; voice therapy after laryngoscopy when indicated.

Sources

Checked October 15, 2026.

Sore throat and possible strep

What to say

Most sore throats are viral, but some are caused by strep bacteria. Symptoms and testing help us decide when antibiotics are useful.

We’ll treat discomfort and test when indicated. If strep is confirmed, take the prescribed antibiotic. Antibiotics don’t help a clearly viral sore throat.

Clinical reference

Before explaining

Assess viral features, testing indication and airway/deep-neck infection signs; adults usually do not need culture after a negative rapid antigen test.

Warning signs

Trouble breathing, drooling, inability to swallow fluids, muffled voice or rapidly worsening one-sided swelling needs urgent assessment.

Follow-up

Review persistent or worsening symptoms; follow current return-to-work guidance after confirmed strep.

Sources

Checked September 24, 2026.

Stye and chalazion

What to say

A stye is a painful red bump from an infected eyelid gland. A chalazion is a firmer, usually painless lump from a blocked gland.

Hold a warm, damp cloth on it for 10 minutes 4 times a day. Don’t squeeze it, and skip eye makeup and contacts until it heals. A lump lasting over a month may need an eye doctor. Get same-day care for spreading redness, fever, eye pain or vision changes.

Clinical reference

Before explaining

Exclude preseptal or orbital cellulitis: fever, diffuse lid swelling, painful eye movements, proptosis or reduced vision.

Warning signs

Enlarging or recurrent same-site lumps, or lash loss, need ophthalmology review; biopsy can exclude eyelid cancer.

Follow-up

Refer if a chalazion persists beyond about a month (incision and curettage or steroid injection).

Sources

Checked October 15, 2026.

Sudden vertigo (vestibular neuritis)

What to say

Vestibular neuritis is inflammation of the inner-ear balance nerve, usually after a virus. It causes constant spinning, nausea and unsteadiness that ease over a few days, with balance returning over 2–6 weeks.

Take dizziness or nausea medicine for 3 days at most, then start walking as soon as you can. Call 911 for double vision, slurred speech, weakness, numbness, a sudden severe headache or being unable to walk. New hearing loss needs same-day care.

Clinical reference

Before explaining

Check hearing, gait and HINTS (if trained); central signs need emergency stroke evaluation, with a low threshold if vascular risk.

Warning signs

Focal deficits, inability to stand, new headache or neck pain suggest stroke or dissection; hearing loss suggests labyrinthitis or sudden SNHL.

Follow-up

Reassess if not improving within a week; refer for vestibular rehabilitation if imbalance persists.

Sources

Checked October 15, 2026.

Temporomandibular disorder

What to say

The jaw joint or chewing muscles can cause pain, clicking and difficulty opening the mouth. Clenching and stress can contribute.

Temporarily choose softer foods, avoid gum and wide opening, and practice relaxing the jaw. Dental or physical-therapy assessment may help if symptoms persist.

Clinical reference

Before explaining

Assess jaw motion, dental disease, trauma and referred pain; consider giant cell arteritis with new headache/jaw claudication.

Warning signs

A locked jaw, major swelling, fever or new headache with vision symptoms needs urgent assessment.

Follow-up

Review eating, opening and pain after conservative care.

Sources

Checked September 24, 2026.

Tinnitus

What to say

Tinnitus is hearing a sound without an outside source. It often accompanies hearing changes, and the level of distress varies.

We’ll check the ears and hearing and discuss ways to reduce its impact on sleep and concentration. Hearing support, sound strategies or therapy can help even when the sound doesn’t disappear.

Clinical reference

Before explaining

Assess unilateral/pulsatile pattern, hearing loss, noise, medicines and distress.

Warning signs

Sudden hearing loss, neurologic symptoms or severe vertigo needs urgent assessment; pulsatile tinnitus needs evaluation.

Follow-up

Review hearing assessment, sleep and coping; refer concerning patterns.

Sources

Checked September 24, 2026.

Neurology & headaches

Bell palsy

What to say

Bell palsy causes weakness on one side of the face, but a new facial droop needs prompt assessment to exclude other causes, including stroke.

If the examination confirms Bell palsy, early treatment may help. Protecting an eye that can’t close is essential. We’ll give you a specific lubrication and closure plan.

Clinical reference

Before explaining

Assess onset, full neurologic examination, ear/skin findings and corneal exposure; consider steroids within 72 hours when appropriate.

Warning signs

Facial weakness with arm weakness or speech trouble means call 911; eye pain or visual change needs urgent review.

Follow-up

Review eye protection and recovery; reassess atypical or incomplete recovery.

Sources

Checked September 24, 2026.

Cluster headache

What to say

Cluster headaches are severe pain around one eye lasting 15 minutes to 3 hours, often with a tearing eye, runny nose and restlessness. Attacks come in groups over weeks or months.

Regular pain pills don’t help. High-flow oxygen by mask or a triptan injection can stop an attack, and verapamil, used off-label, can help prevent them. We’ll arrange a scan and specialist review; call 911 for a headache with weakness, confusion or vision loss.

Clinical reference

Before explaining

Confirm one-sided pain with autonomic signs and restlessness. Discuss imaging and neurology input for a first bout; verapamil needs ECG monitoring.

Warning signs

First-time drooping eyelid or small pupil, headache with weakness, numbness or vision change, or jaw pain with scalp tenderness needs urgent assessment.

Follow-up

Arrange home oxygen (100%, 12 L/min or more, non-rebreather mask) and a triptan supply; short steroid bridge; avoid alcohol during cycles.

Sources

Checked October 15, 2026.

Concussion

What to say

A concussion can affect headache, concentration, balance, sleep and mood even when a scan is normal. Most people improve, but recovery varies.

After a brief period of relative rest, gradually return to light activities that don’t significantly worsen symptoms. Avoid another head injury and get clear guidance before driving, hazardous work or contact sport.

Clinical reference

Before explaining

Assess injury severity, anticoagulants, neurologic signs and need for imaging; provide written recovery guidance.

Warning signs

Worsening severe headache, repeated vomiting, seizure, increasing confusion or weakness needs emergency assessment.

Follow-up

Arrange follow-up for recovery and persistent symptoms; individualize return to work/activity.

Sources

Checked September 24, 2026.

Essential tremor

What to say

Essential tremor usually causes shaking during activities such as writing or holding a cup. We should examine it before assuming that’s the cause.

If it’s mild, practical adjustments may be enough. If it interferes with daily tasks, we can discuss medicines or specialist options after checking other causes and side-effect risks.

Clinical reference

Before explaining

Assess action/rest pattern, symmetry, medications, thyroid clues and parkinsonian/neurologic signs.

Warning signs

Sudden tremor with weakness, speech trouble or severe imbalance needs emergency assessment.

Follow-up

Review functional impact and treatment tolerance.

Sources

Checked September 24, 2026.

First seizure

What to say

A first seizure needs prompt testing, usually blood tests, a brain MRI and an EEG to check brain waves. Missed sleep, alcohol withdrawal or low blood sugar can trigger one.

Don’t drive for now. California requires us to report seizures that cause loss of consciousness or control, and the DMV decides when you can drive again. Don’t swim or bathe alone. Call 911 for a seizure over 5 minutes, repeated seizures, injury or trouble breathing.

Clinical reference

Before explaining

Look for provoked causes (glucose, sodium, withdrawal, drugs); order EEG and MRI; report to local health officer (CA HSC 103900).

Warning signs

Status epilepticus (over 5 minutes or no recovery between seizures), injury or aspiration; mimics include syncope and arrhythmia.

Follow-up

Neurology follow-up: 2-year recurrence risk is 21–45%; immediate ASM lowers it but doesn’t improve long-term remission.

Sources

Checked October 15, 2026.

Giant cell arteritis

What to say

Giant cell arteritis is inflammation of the arteries in the head, usually after age 50. It can cause a new headache, scalp tenderness, jaw pain when chewing and vision changes.

Steroids prevent vision loss and work best started quickly, so we may begin before ultrasound or biopsy confirms it. Go to the emergency department right away for any vision loss or double vision.

Clinical reference

Before explaining

New headache, jaw claudication, scalp tenderness or visual symptoms after 50: check ESR/CRP and start prednisone 40–60 mg before ultrasound or biopsy.

Warning signs

Any vision loss or double vision needs emergency care; new headache with jaw pain or scalp tenderness after 50 needs same-day assessment.

Follow-up

Taper prednisone over 1–2 years or longer; add tocilizumab to spare steroids; protect bones (calcium, vitamin D, DEXA, bisphosphonate); monitor for relapse.

Sources

Checked October 15, 2026.

Living with dementia

What to say

Dementia changes memory and thinking over time. Planning early helps you stay in charge: complete an advance directive, choose someone to decide for you if needed, and talk about driving, money and home safety.

We’ll review medicines that worsen memory, check hearing and vision, and discuss treatments. Stay active and social. Caregivers can call the Alzheimer’s Association 24/7 Helpline at 800-272-3900. Sudden new confusion needs same-day care.

Clinical reference

Before explaining

Review anticholinergics and sedatives, depression, hearing and vision; assess driving (CA reporting if likely to impair), safety and capacity.

Warning signs

Abrupt decline suggests delirium (infection, medicines, urinary retention); watch for wandering, caregiver strain, elder abuse or financial exploitation.

Follow-up

Revisit goals, POLST and caregiver support; consider a cholinesterase inhibitor; refer early Alzheimer’s to assess anti-amyloid eligibility.

Sources

Checked October 15, 2026.

Medication-overuse headache

What to say

Using headache-relief medicine too often can keep headaches recurring, even when the medicine helped at first.

We’ll make a supported plan to reduce or stop the overused treatment and address the underlying headache. Symptoms can temporarily worsen. Opioids or dependence-forming medicines need an individualized withdrawal plan.

Clinical reference

Before explaining

Count headache and medication days; assess drug class, dependence and secondary headache features.

Warning signs

New neurologic signs or thunderclap headache needs emergency assessment; unsafe withdrawal symptoms need urgent help.

Follow-up

Provide early support and reassess four to eight weeks after withdrawal begins.

Sources

Checked September 24, 2026.

Memory concerns and cognitive impairment

What to say

Memory changes deserve assessment, especially when they affect everyday tasks. Sleep, mood, medicines and medical conditions can contribute. Dementia is one possibility, not the only one.

We’ll review the changes, do a cognitive assessment and arrange appropriate tests. With your permission, someone who knows you well can help describe the pattern and support the plan.

Clinical reference

Before explaining

Assess function, trajectory, medications, sensory impairment, mood and reversible causes; discuss driving and home safety.

Warning signs

Sudden confusion or new neurologic signs needs urgent assessment rather than a routine memory appointment.

Follow-up

Arrange results review and specialist assessment when indicated; support patient and caregivers.

Sources

Checked September 24, 2026.

Migraine

What to say

The pattern fits migraine, which can cause head pain along with nausea and sensitivity to light or sound. The aim is to treat an attack early and reduce how much it interrupts your life.

We’ll choose a medicine to take when the migraine starts that’s safe with your medical history and write down when to take it and whether you may repeat it. Please keep track of headache days and medicine days. Needing rescue medicine frequently is a reason to discuss prevention, because frequent use of some headache medicines can make headaches more common. For a sudden explosive headache, new weakness or speech trouble, or fever with a stiff neck, call 911. Contact us promptly for a major change from your usual headache. Your medicine-use limit is [days per week or month for this medicine].

Clinical reference

  • Select a triptan and/or NSAID, acetaminophen or another appropriate acute option from comorbidities and preference; use a drug-specific dosing plan.
  • Discuss prevention when attacks are frequent/disabling or acute treatment is inadequate. Review medication-overuse thresholds by class, not one universal cutoff.

Before explaining

Check pregnancy/postpartum state, cardiovascular disease, medication interactions and secondary-headache flags. Do not offer a triptan indiscriminately for undifferentiated headache.

Warning signs

Thunderclap headache, neurologic deficit, meningism, altered mental status, acute painful visual change or concerning pregnancy/postpartum headache needs an urgent pathway.

Follow-up

Review a headache/medication diary and response over the next several weeks. Set a specific next decision about acute adjustment or prevention.

Sources

Checked September 20, 2026.

New or worrying headache

What to say

Most headaches aren’t dangerous, but some warning signs mean we need to look for another cause.

Call 911 for a sudden, explosive headache, or one with weakness, numbness, confusion, vision loss, trouble speaking, or fever and a stiff neck. Get seen the same day for a new headache after 50 or after a head injury, jaw pain when chewing, or a headache brought on by coughing or exercise or that keeps getting worse.

Clinical reference

Before explaining

Screen SNNOOP10 red flags: systemic signs, cancer or immunosuppression, deficits, thunderclap, older onset, pattern change, positional, Valsalva-triggered, pregnancy.

Warning signs

Thunderclap onset or focal deficits need emergency evaluation; jaw claudication or scalp tenderness needs same-day GCA workup.

Follow-up

Without red flags, imaging is usually unnecessary; treat the primary headache and review analgesic use.

Sources

Checked October 15, 2026.

Parkinson disease

What to say

Parkinson disease happens when brain cells that make dopamine gradually stop working. It causes slowness, stiffness, tremor at rest and walking changes, and can also affect mood, sleep and digestion.

A neurologist confirms the diagnosis. Carbidopa-levodopa eases symptoms, and exercise plus physical, occupational and speech therapy help. Ask us before any new medicine, since some nausea and psychiatric drugs worsen symptoms, and tell us about falls, dizziness on standing or constipation.

Clinical reference

Before explaining

Confirm with neurology; check orthostatic BP, falls, mood, sleep, constipation and cognition. Avoid dopamine blockers (metoclopramide, haloperidol, prochlorperazine).

Warning signs

Sudden worsening or confusion: look for infection, missed doses or a new dopamine blocker. Injurious falls or choking need urgent care.

Follow-up

Neurology follow-up for dosing and complications; encourage regular exercise and PT/OT/speech referral; review falls, mood, sleep and bowels.

Sources

Checked October 15, 2026.

Peripheral neuropathy

What to say

Damage or irritation of peripheral nerves can cause numbness, burning or altered balance, often starting in the feet.

We’ll look for treatable causes such as diabetes, vitamin deficiency or medicine effects. Treatment may reduce pain, while foot checks and protective footwear help prevent injuries you might not feel.

Clinical reference

Before explaining

Assess distribution, strength, reflexes, gait, skin and targeted laboratory tests.

Warning signs

Rapidly progressive weakness, breathing problems or new bowel/bladder dysfunction needs urgent assessment.

Follow-up

Review cause-specific results, pain treatment and foot safety.

Sources

Checked September 24, 2026.

Possible TIA or stroke

What to say

Sudden face drooping, arm weakness, speech trouble, vision loss or severe imbalance can be a stroke. Symptoms that disappear can still signal a TIA and need emergency evaluation.

Call 911 now, note when symptoms began or when you were last well, and don’t drive yourself. Don’t wait to see whether it happens again.

Clinical reference

Before explaining

Activate emergency pathway; establish last-known-well time and medications without delaying transfer.

Warning signs

Any suspected stroke/TIA is an emergency, including resolved symptoms.

Follow-up

After emergency evaluation, confirm prevention treatment, rehabilitation and timely follow-up.

Sources

Checked September 24, 2026.

Tension-type headache

What to say

This headache pattern can feel like pressure or a tight band on both sides of the head. We first check for features suggesting a different cause.

Regular sleep, meals and manageable activity may help. We can discuss occasional pain relief and use a headache diary. Frequent pain-medicine use can itself worsen headaches.

Clinical reference

Before explaining

Assess pattern, neurologic findings, red flags and analgesic frequency.

Warning signs

A sudden worst headache, fever with neck stiffness, new weakness or visual loss needs emergency assessment.

Follow-up

Review frequency and function; consider prevention if frequent.

Sources

Checked September 24, 2026.

Trigeminal neuralgia

What to say

Trigeminal neuralgia causes sudden, brief, electric-shock pain in the face, often set off by touch, chewing, brushing teeth or wind. It’s often from a blood vessel pressing on a facial nerve.

We’ll order an MRI to look for a cause. Carbamazepine, a medicine that calms overactive nerves, often helps; if you have Asian ancestry, we’ll test first for a gene linked to a serious rash. Tell us about new facial numbness or weakness.

Clinical reference

Before explaining

Exclude dental, sinus and neurologic causes; MRI. Before carbamazepine, test HLA-B*1502 if ancestry is at risk, and check sodium, CBC and LFTs.

Warning signs

New numbness, weakness, bilateral pain or onset before 40 suggests a secondary cause; rash or mouth sores on carbamazepine need immediate review.

Follow-up

Reassess pain and tolerability; oxcarbazepine is an alternative with similar HLA-B*1502 caution; refer to neurology or neurosurgery if refractory.

Sources

Checked October 15, 2026.

Mental health, sleep & substance use

Adult ADHD

What to say

ADHD can affect attention, organization and impulse control into adulthood. Diagnosis looks for a longstanding pattern across settings, including symptoms beginning in childhood.

We’ll assess sleep, mood and other conditions that can mimic it, then discuss practical strategies, therapy and medication if appropriate. Treatment should improve the tasks that matter to you.

Clinical reference

Before explaining

Assess developmental history, impairment, comorbidity, substance use and medication-specific cardiovascular risks.

Warning signs

Severe mood change, psychosis or concerning cardiovascular symptoms needs prompt assessment.

Follow-up

Track functional goals, sleep, appetite, BP/pulse and treatment tolerability when applicable.

Sources

Checked September 24, 2026.

Alcohol use disorder

What to say

When drinking becomes difficult to control or keeps causing harm, it’s a treatable health condition. We can discuss help without judging you.

Treatment can include medication, counseling and support that fits your goals. If you drink heavily or have had withdrawal before, stopping suddenly can be dangerous. We need a safe withdrawal plan.

Clinical reference

Before explaining

Assess amount, withdrawal history, liver health, medications, other substances and safety.

Warning signs

Seizure, hallucinations, confusion or severe withdrawal symptoms needs emergency care.

Follow-up

Arrange early follow-up, withdrawal support when needed and ongoing treatment access.

Sources

Checked September 24, 2026.

Bipolar disorder

What to say

Bipolar disorder involves episodes of depression and periods of unusually elevated or irritable mood with changes in energy and sleep. It requires a careful history, not just a mood questionnaire.

We’ll coordinate a treatment plan that helps stabilize mood and protect sleep. Tell us quickly about needing very little sleep, racing thoughts or risky behavior.

Clinical reference

Before explaining

Assess past mania/hypomania, psychosis, substances, suicidality and current treatment; avoid reflex antidepressant monotherapy in bipolar I.

Warning signs

Mania with unsafe behavior, psychosis or suicidal intent needs urgent assessment.

Follow-up

Arrange prompt mental-health follow-up and medicine-specific monitoring.

Sources

Checked September 24, 2026.

Cannabis use

What to say

Cannabis is legal for adults 21 and older in California, but today’s products are much stronger than before. Daily use can lead to dependence and, in some people, psychosis or repeated severe vomiting.

We can help you cut back or stop; irritability and poor sleep can happen at first. Don’t drive high, and lock edibles away from children. Vomiting you can’t stop or seeing things that aren’t there needs urgent care.

Clinical reference

Before explaining

Ask about frequency, products, THC strength and route; screen for use disorder, mood, anxiety and psychosis; review sedatives, opioids and warfarin; CBD raises clobazam levels.

Warning signs

Cyclic vomiting eased by hot showers suggests cannabinoid hyperemesis syndrome (resolves only with stopping); dehydration, chest pain or psychosis needs urgent care.

Follow-up

Agree on a goal (cut down or stop); offer CBT, motivational enhancement or contingency management; no FDA-approved medicine; follow up in a few weeks.

Sources

Checked October 15, 2026.

Depression

What to say

What you’ve described fits depression, which can affect sleep, energy, concentration and the ability to enjoy things. It isn’t a personal failure. Treatment can include talking therapy, medication, or both, and we can choose a starting point together.

Before we decide on treatment, I want to ask directly about safety: have you had thoughts of hurting yourself or of not wanting to be alive?

If we start medicine, benefit builds over several weeks, and we’ll check in earlier about side effects and how you’re doing. New agitation, feeling unusually energized with very little sleep, or worsening thoughts of self-harm means contact us the same day. If you might act on those thoughts or can’t stay safe, call 911. 988 can provide immediate crisis support.

Clinical reference

  • Assess diagnosis, severity, function, suicidality, psychosis, bipolarity and treatment preferences. A screening score supports but does not replace assessment.
  • Offer evidence-based psychotherapy and/or medication according to severity and preference; explain onset, continuation and discontinuation planning.
  • Pause for the patient’s answer to the safety question and complete the risk assessment before continuing the treatment script.

Before explaining

Assess current safety during the visit and arrange urgent help if required. Review substances, medications, medical contributors and previous treatment response.

Warning signs

Suicidal intent/plan, inability to stay safe, psychosis or mania can change the care setting. Do not respond solely with a routine prescription or a distant follow-up.

Follow-up

Review usually within two weeks after an antidepressant start; within one week for ages 18–25 or heightened suicide risk, and sooner when clinical risk requires. Agree on a safety/contact plan.

Sources

Checked September 20, 2026.

Eating disorders

What to say

Eating disorders are serious illnesses, not choices, and occur at every body size. They include binge eating, bulimia, anorexia and severe food avoidance, and can affect your heart, blood salts and bones.

Treatment works best with a team: therapy focused on eating, a dietitian and regular medical checks. Medicine helps some types. Fainting, chest pain, a racing or very slow heartbeat, or not being able to eat or drink means go to the emergency department.

Clinical reference

Before explaining

Screen at any weight with neutral, non-weight-focused language. Check orthostatic vitals, temperature, CBC and CMP; ECG if restricting or purging.

Warning signs

Consider admission (APA 2023): HR <50, BP <90/60, orthostatic changes, temperature <36°C, hypokalemia, syncope, QTc >450 or rapid weight loss.

Follow-up

Coordinate ED-focused CBT (FBT for young adults with involved family), dietitian and medical monitoring. Fluoxetine 60 mg for bulimia; lisdexamfetamine for BED.

Sources

Checked October 15, 2026.

Gambling problems

What to say

Gambling can take over: chasing losses, hiding bets, or borrowing money. It’s a treatable health condition, and many people feel ashamed, so thank you for telling me.

Counseling, especially cognitive behavioral therapy, and Gamblers Anonymous can help, as can blocking betting sites and apps and limiting access to your money. The free, confidential California helpline, 1-800-GAMBLER (1-800-426-2537), answers day and night. If you ever think about ending your life, call or text 988.

Clinical reference

Before explaining

Ask about debt, lying about gambling and chasing losses. Screen for depression, suicidal thoughts, alcohol or other substance use, and anxiety.

Warning signs

Gambling disorder carries suicide risk. Ask directly; any suicidal thoughts need same-day assessment. Ask about crisis debt or legal trouble.

Follow-up

Offer CBT or addiction referral, Gamblers Anonymous and the helpline (text SUPPORT to 53342); recheck gambling, mood, debt and safety within weeks.

Sources

Checked October 15, 2026.

Generalized anxiety

What to say

Anxiety can keep the body’s alarm system switched on even when there’s no immediate danger. The worry and physical symptoms are real, and they can become exhausting. We can treat both the symptoms and the pattern that keeps them going.

Talking therapy can help you practice responding differently to worry. A daily medicine is another option. It works gradually, rather than stopping one anxious moment on demand. Some people feel temporarily more restless when starting, so tell me if it’s troublesome. Marked agitation or new thoughts of self-harm means call us the same day. If you can’t stay safe, call 911. We’ll also look at sleep, caffeine and anything else that may be amplifying symptoms. Which part is interfering most with your day, and which treatment approach feels workable to you?

Clinical reference

  • Confirm the syndrome and impairment; distinguish panic, PTSD, OCD, depression, bipolarity, substance effects and medical mimics.
  • Offer CBT/applied relaxation or an appropriate SSRI/SNRI according to preference and prior response. Routine long-term benzodiazepines are not the default plan.

Before explaining

Review suicidality, past mania, alcohol/sedative use and barriers to therapy. Do not label new concerning chest symptoms or syncope as anxiety without assessment.

Warning signs

New suicidal thoughts, marked activation or manic features warrant same-day contact; inability to remain safe requires emergency help.

Follow-up

NICE GAD guidance: review SSRI/SNRI starts within one week in adults under 30 and monitor self-harm/suicide risk weekly for the first month; other routine medication reviews every 2–4 weeks during the first three months. Adapt to clinical risk and local care. Assign a next step if therapy access is delayed.

Sources

Checked September 20, 2026.

Grief and bereavement

What to say

Grief is a normal response to loss. It can come in waves and disturb sleep, appetite and concentration. There’s no right way or timeline to grieve.

Rest, regular meals, activity and people you trust can help, as can grief counseling or a support group. Tell us if you’re drinking more to cope, grief keeps disrupting daily life, or you have thoughts of suicide. In a crisis, call or text 988.

Clinical reference

Before explaining

Screen for depression, suicidal thoughts, alcohol or sedative use, sleep and daily function; ask about support and practical stressors.

Warning signs

Suicidal thoughts, major depression, heavy drinking, or prolonged grief disorder (≥12 months after the loss, near-daily intense yearning or preoccupation, impairment) need treatment.

Follow-up

Recheck in a few weeks; refer for grief-focused therapy (CBT-based) for prolonged grief disorder; offer support groups. No medicine treats grief itself.

Sources

Checked October 15, 2026.

Intimate partner violence

What to say

Abuse by a partner is common and never your fault. I ask everyone privately. Before you share: if I see or treat an injury caused by abuse, California law requires me to report it to police.

We can make a safety plan, and you choose your next steps. If you’ve been choked, get checked today, even without marks. For confidential help, call 1-800-799-7233 or text START to 88788. If you’re in danger, call 911.

Clinical reference

Before explaining

Ask alone, with a professional interpreter; explain reporting limits first. CA Penal Code 11160: when you provide care for a physical condition, a known or suspected current injury from assaultive or abusive conduct must be phoned to local police immediately or as soon as practically possible, then reported on the written Cal OES form within 2 working days.

Warning signs

Strangulation, even without visible marks: same-day ED evaluation (possible carotid, vertebral or airway injury); it signals high homicide risk. Ask about firearms, escalating threats and children at home.

Follow-up

Document the patient’s words, a body map of injuries and a copy of the report (PC 11161); offer advocate referral and safety planning; agree on a safe way to contact.

Sources

Checked October 15, 2026.

Long-term benzodiazepine use

What to say

Taking a benzodiazepine for months or years can raise the risk of falls, memory problems, car crashes and overdose, especially with alcohol or opioids. Your body also adapts, which is expected and isn’t addiction.

Never stop suddenly; that can cause seizures. If we lower the dose, we’ll go slowly and can pause if needed. Therapy can help sleep and anxiety. Call 911 for a seizure, confusion or hallucinations.

Clinical reference

Before explaining

Review indication, dose, duration, CURES, opioids, alcohol and other sedatives, falls, cognition and driving; decide on tapering together; offer naloxone if opioids are co-prescribed.

Warning signs

Withdrawal or rebound symptoms (insomnia, anxiety, tremor) mean slow or pause the taper; seizures or delirium need emergency care.

Follow-up

If likely dependent, taper rather than stop: start with 5–10% reductions every 2–4 weeks (≤25% per 2 weeks), slower if strongly dependent; check in at each step; offer CBT or CBT-I.

Sources

Checked October 15, 2026.

Long-term opioid therapy

What to say

Daily opioids for long-term pain help some people function better but carry risks, including overdose, dependence, constipation, falls and breathing problems during sleep. We’ll regularly check that the benefits still outweigh the harms.

Keep naloxone at home and show others how to use it. Avoid alcohol, and don’t add sleep or anxiety medicines without asking us. Don’t stop suddenly; we’ll make any changes slowly, together. If you can’t be woken or your breathing is slow, others should give naloxone and call 911.

Clinical reference

Before explaining

Set function goals and an exit plan. Check CURES before the first prescription and at least every 6 months; review MME, sedatives, sleep apnea, depression and OUD.

Warning signs

Offer naloxone, especially at ≥50 MME, with benzodiazepines, sleep-disordered breathing or SUD/overdose history. Monitor falls, constipation, hypogonadism and misuse; avoid abrupt tapers.

Follow-up

Reassess 1–4 weeks after starting or increasing, then at least every 3 months. After ≥1 year, taper about 10% per month or slower; offer MOUD for OUD.

Sources

Checked October 15, 2026.

Methamphetamine or cocaine use

What to say

Meth and cocaine can cause heart attack, stroke, overheating, paranoia and psychosis. Street drugs can contain fentanyl, which can cause a deadly overdose.

If you use, carry naloxone, test drugs for fentanyl, and don’t use alone. We can test for HIV and hepatitis and offer HIV prevention medicine. Counseling and reward-based programs can help you cut back or stop. For chest pain, stroke signs, overheating or severe agitation, call 911.

Clinical reference

Before explaining

Ask nonjudgmentally about drug, route, frequency, injection and co-use (opioids, alcohol); check BP, heart and mental health; offer HIV, HCV and STI testing.

Warning signs

Chest pain, stroke symptoms, hyperthermia, severe agitation or psychosis: 911 or ED. Slowed or stopped breathing suggests opioid co-exposure; give naloxone.

Follow-up

No FDA-approved medicine; offer contingency management (Medi-Cal Recovery Incentives and other SF programs) and CBT; provide naloxone; Never Use Alone line 800-484-3731.

Sources

Checked October 15, 2026.

Nightmares

What to say

Nightmares are vivid, frightening dreams that wake you up. They’re common, and stress, trauma, alcohol and some medicines can trigger them.

If they’re frequent, treatment helps. In imagery rehearsal therapy, you rewrite a nightmare with a calmer ending and practice it while awake. Tell us if you act out dreams or injure yourself or a partner in your sleep. If you think about harming yourself, call or text 988, or call 911 if you might act.

Clinical reference

Before explaining

Screen for PTSD, depression and sleep apnea. Review medicines (antidepressants, antihypertensives, Parkinson drugs) and alcohol, sedative or opioid use or withdrawal.

Warning signs

Dream enactment or injury suggests REM sleep behavior disorder; arrange sleep evaluation. Suicidal thoughts or severe PTSD symptoms need prompt assessment.

Follow-up

Refer for imagery rehearsal therapy (AASM: recommended). Prazosin (off-label) “may be used” for PTSD nightmares; trial evidence is mixed. Reassess in weeks.

Sources

Checked October 15, 2026.

Obsessive-compulsive disorder

What to say

OCD can cause unwanted intrusive thoughts and rituals that briefly ease anxiety but take over time and daily life. Having an unwanted thought doesn’t mean you want it to happen.

A therapy called exposure and response prevention can help, and medicines are another option. We’ll assess what you experience without judging the content of the thoughts.

Clinical reference

Before explaining

Distinguish intrusive unwanted thoughts from intent, psychosis and other conditions; assess impairment and safety.

Warning signs

Suicidal intent, inability to care for basic needs or immediate danger requires urgent intervention.

Follow-up

Review time spent on rituals, function and access to appropriate therapy.

Sources

Checked September 24, 2026.

Opioid use disorder

What to say

Opioid use disorder is treatable. Medicines such as buprenorphine or methadone can reduce cravings and lower the risk of overdose.

We can help you start evidence-based treatment and obtain naloxone. Counseling can help, but difficulty accessing counseling shouldn’t stop us from connecting you with medication treatment.

Clinical reference

Before explaining

Assess intoxication, withdrawal, opioid exposure, other sedatives, pregnancy and treatment access; plan induction safely.

Warning signs

Unresponsiveness or slow/absent breathing means call 911, give naloxone and provide rescue breathing/CPR as directed.

Follow-up

Arrange rapid treatment connection, naloxone education and close early follow-up.

Sources

Checked September 24, 2026.

Panic attacks

What to say

A panic attack can cause intense fear with a racing heart, breathlessness or tingling. Those sensations are real, but new symptoms still need assessment for medical causes.

Once we have assessed this pattern, therapy can help you respond differently to the sensations and reduce avoidance. Medication is another option if attacks are recurring or limiting your life.

Clinical reference

Before explaining

Assess medical/substance causes, avoidance, depression and safety; distinguish an attack from panic disorder.

Warning signs

New chest pain, fainting or severe breathing difficulty needs urgent medical assessment.

Follow-up

Review attack frequency, avoidance and treatment response.

Sources

Checked September 24, 2026.

Persistent insomnia

What to say

The first treatment I’d suggest is cognitive behavioral therapy for insomnia, or CBT-I. It’s a structured way to change the sleep patterns and worry that can keep insomnia going. It’s more than a list of general bedtime-habit advice.

We’ll look at your schedule, time awake in bed, caffeine, alcohol and medicines, and choose changes you can actually make. Sleep medicines sometimes have a limited role, but they can cause next-day sleepiness or other problems, so I don’t want to start an open-ended nightly prescription without a plan. If you snore loudly, stop breathing during sleep or are dangerously sleepy in the day, tell me. Those clues may need a different assessment. Don’t drive or operate machinery when sleepy. The next step for CBT-I is [service and how to arrange it].

Clinical reference

  • Offer or refer for CBT-I as first-line treatment for chronic insomnia, with an accessible delivery option.
  • Review sleep opportunity, schedule, mood, substances, medications, sleep apnea and restless legs. Medication requires an indication-specific, time-limited benefit/harm discussion.

Before explaining

Assess bipolar activation, severe depression/suicidality, sedative use and withdrawal, occupational/driving risk and untreated sleep disorders. Tailor behavioral components to comorbidity.

Warning signs

Dangerous daytime sleepiness requires driving/work safety advice. Mania, acute self-harm risk or sedative withdrawal changes the care pathway.

Follow-up

Use a sleep diary and schedule review of sleep/function and access to CBT-I, often in a few weeks. Assign an alternative if the first referral is inaccessible.

Sources

Checked September 20, 2026.

Post-traumatic stress disorder

What to say

After trauma, the brain and body can keep reacting as though danger is present. Nightmares, avoidance and feeling constantly on guard can be part of PTSD.

You don’t have to describe everything today. We can start with safety and what is affecting daily life, then discuss trauma-focused therapy and medication if useful.

Clinical reference

Before explaining

Assess current danger, suicidality, sleep, substance use and functional impact with consent and sensitivity.

Warning signs

Immediate danger or intent to self-harm needs emergency support; call/text 988 for a U.S. crisis, or 911 for imminent danger.

Follow-up

Make a concrete follow-up and therapy connection; review safety and access barriers.

Sources

Checked September 24, 2026.

Quitting vaping

What to say

Most vapes contain nicotine, which is addictive, so cravings, irritability and trouble focusing are common when you stop. Pick a quit date, notice your triggers and plan what you’ll do instead.

Nicotine patches with gum or lozenges, or varenicline, can help; using them for vaping is off-label. Kick It California (800-300-8086) offers free coaching, texts and an app. If you also smoke, we’ll plan to stop both. New cough, chest pain or shortness of breath needs prompt care.

Clinical reference

Before explaining

Ask device, nicotine strength, pods or mL per day, THC vaping and smoking; base NRT dose on daily use. California bans flavored vape sales.

Warning signs

EVALI, mostly from THC or vitamin E acetate products: cough, dyspnea, chest pain, GI symptoms or fever need urgent assessment.

Follow-up

Follow up near the quit date; adjust NRT or varenicline for cravings. Treat slips as learning and prevent relapse to smoking.

Sources

Checked October 15, 2026.

Restless legs syndrome

What to say

Restless legs causes an urge to move, usually with uncomfortable sensations that worsen at rest and in the evening and improve with movement.

We’ll review iron status, medicines and sleep habits. If symptoms keep disrupting sleep, we can discuss treatment while weighing side effects and the risk of symptoms worsening with some drugs over time.

Clinical reference

Before explaining

Confirm characteristic pattern; assess iron indices, renal disease, pregnancy and aggravating medicines.

Warning signs

New weakness, persistent numbness or a painful swollen leg needs separate assessment.

Follow-up

Review sleep, iron evaluation and treatment response; watch for earlier/more widespread symptoms on therapy.

Sources

Checked September 24, 2026.

Seasonal affective disorder

What to say

Seasonal affective disorder is depression that returns each fall or winter and eases in spring. It’s a real, treatable condition, not a weakness.

Options include a 10,000-lux light box for about 30 minutes after waking, talk therapy, and antidepressants. Starting prevention in early fall can help. If you have thoughts of harming yourself, call or text 988, or call 911 if you might act on them.

Clinical reference

Before explaining

Screen for bipolar disorder and suicidality. Before light therapy, check for eye disease and photosensitizing medicines; mania is a rare light-therapy effect.

Warning signs

Suicidal thoughts need same-day assessment. Mania, or no improvement after 3–4 weeks of light therapy, needs review.

Follow-up

Review response 3–4 weeks after starting treatment; plan early-fall prevention (light, therapy or bupropion XL) before next winter.

Sources

Checked October 15, 2026.

Social anxiety disorder

What to say

Social anxiety disorder is an intense, lasting fear of being judged or embarrassed, so everyday situations like meetings feel threatening or get avoided. It’s common and treatable.

Therapy that helps you gradually face these situations works well. A daily medicine can help over several weeks; propranolol is only for occasional events like a talk. Tell us about low mood or using alcohol to cope. For thoughts of self-harm, call us the same day; in a crisis, call 988 or 911.

Clinical reference

Before explaining

Screen for depression, suicidality, alcohol or substance use and other anxiety disorders. Separate performance-only anxiety; consider medical causes.

Warning signs

Same-day review for suicidal thoughts or worsening depression. Don’t routinely use benzodiazepines (NICE); watch for alcohol used to cope.

Follow-up

Offer individual CBT with exposure first; SSRI or venlafaxine XR if preferred. Check early tolerance and judge response at 10–12 weeks.

Sources

Checked October 15, 2026.

Stress and burnout

What to say

Long-term work stress can lead to burnout: exhaustion, feeling detached or cynical about work, and feeling less effective. It’s real, though not a medical diagnosis, and it can overlap with depression, anxiety or sleep problems.

We’ll check for those and for physical causes. Sleep, exercise, setting limits, therapy and changes at work, including time off, can help. If you have thoughts of suicide, call or text 988.

Clinical reference

Before explaining

Screen for depression, anxiety, alcohol or other substance use, sleep problems and suicidal thoughts; consider medical causes of fatigue (e.g., TSH, CBC) when indicated.

Warning signs

Symptoms beyond work suggest depression or an anxiety disorder (ICD-11 limits burnout to the work context); suicidal thoughts need same-day assessment.

Follow-up

Recheck mood, sleep and function in a few weeks; support therapy (e.g., CBT), workplace accommodations or leave paperwork as appropriate.

Sources

Checked October 15, 2026.

Suicidal thoughts

What to say

Thoughts of suicide can come when pain feels unbearable, and they often rise and fall. Talking about them doesn’t make them more likely; it helps us keep you safe.

Together we’ll make a safety plan: warning signs, what helps, who to call, and making home safer, like storing guns elsewhere and locking up medicines. Call or text 988 anytime. If you might act on these thoughts, call 911.

Clinical reference

Before explaining

Ask directly (e.g., ASQ): thoughts, plan, intent, timing, past attempts, access to firearms or stockpiled medicines, substance use and supports.

Warning signs

Intent, a plan, a recent attempt or inability to stay safe (especially with firearm access, intoxication or psychosis): don’t leave the patient alone; arrange emergency evaluation (911 or ED).

Follow-up

Contact within days; review the safety plan and lethal-means steps; treat underlying conditions; consider caring contacts (brief supportive messages).

Sources

Checked October 15, 2026.

Tobacco dependence

What to say

Nicotine dependence makes stopping difficult, and needing more than one attempt is common. Treatment can make quitting more manageable.

We can combine counseling with a suitable medicine or nicotine replacement and plan for cravings and triggers. A slip is information for adjusting the plan, not a reason to give up.

Clinical reference

Before explaining

Assess tobacco/nicotine products, past attempts, pregnancy, contraindications and preferences.

Warning signs

New chest pain or severe breathing symptoms needs urgent assessment rather than attribution to quitting.

Follow-up

Arrange support near the quit date and review cravings, adverse effects and lapses.

Sources

Checked September 24, 2026.

General symptoms & healthy aging

After a hospital stay

What to say

The first weeks after a hospital stay are a vulnerable time, so we want to see you within 1 to 2 weeks, on [date]. Bring every medicine and supplement so we can review what’s new, changed or stopped.

We’ll also check pending results, home health and equipment. Call us if your original problem seems to return, you can’t take your medicines, or you’re newly confused. Call 911 for trouble breathing, chest pain or fainting.

Clinical reference

Before explaining

Contact within 2 business days; visit within 7 days if high complexity, otherwise 14; reconcile medicines by the visit; review pending results.

Warning signs

Medication errors, return of the admitting problem, new confusion or functional decline, and missed follow-up raise readmission risk.

Follow-up

Confirm medication reconciliation, pending results, referrals and equipment; reassess function and goals; give one point of contact.

Sources

Checked October 15, 2026.

Caregiver strain

What to say

Caring for someone every day is hard work, and many caregivers end up exhausted, anxious or isolated while putting their own health last. Needing help doesn’t mean you’re failing.

We’ll check your health, sleep and mood, and connect you with respite care, adult day care or a caregiver support group. If you feel you might hurt yourself or the person you care for, call or text 988, or call 911 in an emergency.

Clinical reference

Before explaining

Screen for depression, anxiety, sleep loss, substance misuse and missed preventive care; ask about the safety of the person receiving care.

Warning signs

Hopelessness, self-harm thoughts, or fear of harming the person cared for need same-day attention (988); suspected neglect needs urgent action.

Follow-up

Offer respite, Family Caregiver Alliance (San Francisco), IHSS for care recipients eligible for Medi-Cal, and Paid Family Leave; recheck mood and caregiving load.

Sources

Checked October 15, 2026.

Chronic pain

What to say

Pain that lasts can affect sleep, mood and daily activities. It remains real even when a scan doesn’t fully explain it.

We’ll set goals around what you want to do and combine suitable movement, rehabilitation, coping skills and medicines when useful. Each treatment should earn its place through meaningful benefit and acceptable harms.

Clinical reference

Before explaining

Reassess diagnosis and new red flags; review function, mental health, medicines and substance risks. Tailor activity for post-exertional illness.

Warning signs

New weakness, bowel/bladder changes, fever or other major change needs reassessment; avoid assuming all symptoms are chronic pain.

Follow-up

Review function and treatment benefit regularly; do not abruptly stop long-term dependence-forming medicines.

Sources

Checked September 24, 2026.

Driving safety in older adults

What to say

Changes in vision, hearing, memory, reaction time, movement or medicines can make driving less safe. Near misses, new dents, tickets or getting lost on familiar roads are warning signs.

We’ll check your vision, thinking and medicines and may suggest a professional driving evaluation. Daytime driving on familiar routes can help, and we’ll plan other ways to get around. California law requires us to report some conditions, like dementia that impairs driving, to public health, which notifies the DMV.

Clinical reference

Before explaining

Assess vision, cognition, sedating drugs and mobility. California (HSC 103900): report lapse-of-consciousness disorders, including driving-impairing dementia, to the local health officer.

Warning signs

Crashes, near misses, getting lost or family concern warrant prompt formal evaluation rather than waiting for a routine visit.

Follow-up

Refer for an OT driving evaluation when in doubt; involve family with permission; plan transportation and revisit as conditions change.

Sources

Checked October 15, 2026.

Food allergy and anaphylaxis

What to say

Food allergy reactions are unpredictable, and the next one may be worse than past ones. Avoid the food, read labels and ask about ingredients when eating out.

Carry 2 epinephrine doses everywhere and follow your written action plan. For trouble breathing, throat tightness, faintness, or hives with vomiting, use epinephrine right away, then call 911. Allergy pills don’t replace epinephrine. We’ll refer you to an allergist.

Clinical reference

Before explaining

Confirm IgE-mediated allergy with an allergist; ask about delayed reactions to red meat after tick bites (alpha-gal).

Warning signs

Any anaphylaxis needs epinephrine and emergency evaluation; biphasic reactions can occur up to 12–24 hours later.

Follow-up

Allergist to confirm triggers and discuss omalizumab or oral immunotherapy; review device technique, expiry and action plan regularly.

Sources

Checked October 15, 2026.

Frailty

What to say

Frailty means the body has less reserve to recover from an illness or setback. It varies between people and doesn’t by itself define what you can do or what care you should receive.

We’ll focus on your priorities, nutrition, strength, medicines and support at home. A coordinated plan can help preserve independence and avoid treatments whose burdens outweigh their benefits.

Clinical reference

Before explaining

Assess function, cognition, nutrition, medication burden, support and goals through a holistic review.

Warning signs

A sudden decline, new confusion or inability to manage basic needs requires prompt assessment for acute illness.

Follow-up

Agree on functional goals and review after illness or a change in support needs.

Sources

Checked September 24, 2026.

Getting ready for surgery

What to say

Before surgery, we review your heart, lungs and other conditions and plan your medicines. Many people need no extra tests. Your surgeon and anesthesia team make the final decision.

Bring a list of every medicine and supplement. We’ll give you a plan for blood thinners, diabetes and weight-loss medicines; don’t change them on your own. Bring your CPAP if you use one, and stop smoking now. Call us about new chest pain, breathlessness or illness before surgery.

Clinical reference

Before explaining

Assess active cardiac conditions, surgical risk and functional capacity (e.g., stair climbing); order ECG or labs only when indicated.

Warning signs

Unstable angina, decompensated HF, significant arrhythmia, symptomatic severe valve disease or acute illness: postpone elective surgery and reassess.

Follow-up

SGLT2i: stop 3 days before (ertugliflozin 4). GLP-1 RAs: usually continue; 24-hour liquid diet if high risk. Anticoagulants: per procedure bleeding risk.

Sources

Checked October 15, 2026.

Heat illness

What to say

Heat exhaustion causes heavy sweating, weakness, dizziness and nausea. Move somewhere cool, rest and sip fluids. Older age, alcohol, heart disease and some medicines, such as water pills, raise your risk.

Heat stroke is an emergency: confusion, fainting, seizures or a very high temperature. Call 911, move the person to a cool place and cool them with wet cloths and a fan. Ask us how to adjust medicines for heat waves.

Clinical reference

Before explaining

Heat stroke is neurologic change with temperature above 104°F; review diuretics, anticholinergics, psychotropics, stimulants and alcohol.

Warning signs

Confusion, seizures, fainting, fever above 102°F or worsening despite cooling need 911; no oral fluids if vomiting or not alert.

Follow-up

Make a heat plan: review medicines and fluid limits, avoid abrupt stops, arrange cooling and check-ins during heat waves.

Sources

Checked October 15, 2026.

Iron-deficiency anemia

What to say

Your blood count is low because there isn’t enough iron to make normal red blood cells. Replacing iron helps, but we also need to find why it’s low.

Possible causes include blood loss or difficulty absorbing iron. We’ll treat the deficiency and arrange the appropriate evaluation rather than assume diet alone explains it.

Clinical reference

Before explaining

Confirm iron deficiency; assess menstrual/GI loss, medications, celiac disease and age/risk-appropriate GI investigation.

Warning signs

Chest pain, fainting, breathlessness at rest, black stool or active heavy bleeding needs urgent assessment.

Follow-up

Recheck blood-count response and iron stores; track cause evaluation to completion.

Sources

Checked September 24, 2026.

Loneliness and social isolation

What to say

Many people feel lonely, and over time it is linked with depression, heart disease and memory decline. You can feel lonely even around people. It isn’t a personal failing.

We’ll check mood, hearing and getting around, then help you find steps that fit: calls, classes, volunteering or a senior center. If you’re 60 or older, the free Friendship Line, 888-670-1360, is open 24 hours. For thoughts of suicide, call or text 988.

Clinical reference

Before explaining

Screen for depression and suicidal thoughts; look for hearing or vision loss, limited mobility or transportation, bereavement, caregiving and alcohol use.

Warning signs

Suicidal thoughts need same-day assessment and 988 or 911; withdrawal, self-neglect or new cognitive change needs evaluation.

Follow-up

Link to hearing care, transportation, senior centers and volunteering; Friendship Line for ages 60+; recheck connection and mood.

Sources

Checked October 15, 2026.

Long COVID

What to say

Symptoms can persist or develop after COVID and affect several parts of the body. The symptoms are real, even when routine tests are normal.

We’ll evaluate treatable causes and build a symptom-focused plan. If exertion causes a delayed worsening, pacing within your limits is important. A fixed exercise increase may be harmful.

Clinical reference

Before explaining

Assess functional impact, cardiopulmonary symptoms, orthostasis, sleep and post-exertional malaise; do not attribute all new symptoms to Long COVID.

Warning signs

New chest pain, severe breathlessness, fainting or focal neurologic symptoms needs urgent assessment.

Follow-up

Review symptoms, function, accommodations and access to rehabilitation suited to tolerance.

Sources

Checked September 24, 2026.

ME/CFS

What to say

ME/CFS can cause profound fatigue, unrefreshing sleep and a worsening after physical or mental effort called post-exertional malaise. Pushing through can trigger a setback.

We’ll work on pacing within your energy limits and treating symptoms such as sleep problems or dizziness. Activity should be adjusted to your response, not increased on a fixed schedule.

Clinical reference

Before explaining

Assess diagnostic criteria, competing causes, orthostatic intolerance and functional support needs.

Warning signs

New focal symptoms, chest pain or severe breathlessness needs separate assessment.

Follow-up

Review energy limits, symptom treatments and practical supports without pressure to exceed tolerance.

Sources

Checked September 24, 2026.

Medication review for older adults

What to say

A medication review checks that each medicine still helps more than it harms. With age, some medicines, such as certain sleep aids and allergy pills, raise the risk of falls, confusion or bleeding.

Bring all your prescriptions, over-the-counter medicines and supplements. We’ll make changes gradually, usually one at a time, and may simplify your schedule. Using one pharmacy helps catch interactions. Don’t stop a medicine on your own; some must be reduced slowly.

Clinical reference

Before explaining

Reconcile prescriptions, OTCs and supplements; screen with AGS Beers 2023: anticholinergics, benzodiazepines, Z-drugs, PPIs >8 weeks, sulfonylureas, primary-prevention aspirin.

Warning signs

Watch for withdrawal or symptom return after stopping (e.g., benzodiazepines) and for falls, delirium or hypoglycemia while drugs are adjusted.

Follow-up

Change one drug at a time, document the reason and plan, and recheck symptoms after each change.

Sources

Checked October 15, 2026.

Night sweats

What to say

Night sweats are sweats that soak your nightclothes or sheets even though your room is cool. Common causes include menopause, some medicines, alcohol, anxiety, reflux and sleep apnea.

We’ll review your medicines and symptoms and may order tests. Tell us promptly about fever, cough, weight loss without trying, or swollen glands, since infections, thyroid problems and other illnesses can also cause night sweats.

Clinical reference

Before explaining

Review medicines, alcohol, menopause, reflux, sleep apnea, thyroid. If fever, cough, weight loss or nodes: CBC, HIV, TB test, chest X-ray.

Warning signs

Fever, weight loss, cough, swollen nodes or drenching sweats most nights suggest infection or lymphoma and need prompt evaluation.

Follow-up

Reassess after medicine changes and results; if unexplained and persistent, repeat the history and examination and broaden testing.

Sources

Checked October 15, 2026.

Persistent enlarged lymph nodes

What to say

Lymph nodes often enlarge while fighting an infection. A node that persists, grows or has unusual features needs further assessment.

We’ll examine the area and look for infection or other causes, then decide whether observation, tests or a biopsy is appropriate. A definite follow-up date matters.

Clinical reference

Before explaining

Assess duration, location, size, consistency, generalized nodes and systemic symptoms.

Warning signs

Rapid enlargement, difficulty breathing/swallowing or severe illness needs urgent care; night sweats/weight loss warrants prompt workup.

Follow-up

Recheck on [date]; investigate persistent, enlarging or suspicious nodes.

Sources

Checked September 24, 2026.

Persistent fatigue

What to say

Ongoing fatigue can come from sleep problems, mood, medicines or a physical illness. We should understand the pattern rather than dismiss it or order every test at once.

We’ll review sleep, daily function and associated symptoms, then choose targeted tests. If activity causes a delayed crash, tell me so the activity plan doesn’t make things worse.

Clinical reference

Before explaining

Assess duration, sleep apnea, mood, medications, bleeding, weight change and post-exertional symptoms.

Warning signs

Chest pain, breathlessness at rest, fainting or new neurologic symptoms needs urgent assessment.

Follow-up

Review test results and function on a set date; reassess unresolved symptoms.

Sources

Checked September 24, 2026.

Pre-travel visit

What to say

A travel visit plans for the health risks of your trip. Book it at least a month before you leave and bring your itinerary and vaccine records. We may recommend vaccines, malaria pills and a plan for travelers’ diarrhea.

Pack medicines in your carry-on, in their original containers, and consider travel health and evacuation insurance. If you get a fever during or after your trip, get care promptly and say where you traveled.

Clinical reference

Before explaining

Review itinerary, activities, trip length, vaccine history, pregnancy, immune status and chronic conditions; yellow fever vaccine only at registered clinics.

Warning signs

Fever after travel to a malaria area needs same-day assessment and malaria testing.

Follow-up

Refer complex itineraries to a travel clinic; document vaccines given and the malaria and diarrhea plans.

Sources

Checked October 15, 2026.

Recurrent falls

What to say

Repeated falls often have several contributors, such as balance, vision, medicines or blood-pressure changes. We can reduce risk without simply asking you to be less active.

We’ll review what happens around each fall, your walking and home setup, then plan strength and balance support and medication changes where useful.

Clinical reference

Before explaining

Assess injury, syncope, orthostasis, gait, vision, feet, medications and fracture risk.

Warning signs

Head injury on blood thinners, inability to bear weight, new weakness or loss of consciousness needs urgent assessment.

Follow-up

Review falls, confidence and completion of therapy/home-safety changes.

Sources

Checked September 24, 2026.

Unintentional weight loss

What to say

Losing weight without trying deserves assessment. Appetite, digestion, medicines, mood and several illnesses can contribute.

We’ll check the amount and timing, examine you and arrange tests guided by the findings. We should also support nutrition while investigating the cause.

Clinical reference

Before explaining

Confirm weight trend; assess intake, swallowing, GI symptoms, systemic symptoms and psychosocial factors.

Warning signs

Inability to eat/drink, bleeding, severe weakness or rapid deterioration needs urgent care.

Follow-up

Arrange prompt results and weight review; continue evaluation if the loss remains unexplained.

Sources

Checked September 24, 2026.

Vitamin B12 deficiency

What to say

Low B12 can affect blood cells and nerves, sometimes causing tingling, balance changes or memory symptoms. The cause determines how replacement is given and how long it’s needed.

We’ll start appropriate replacement and look for dietary, medication or absorption causes. Tell us about nerve symptoms promptly because prolonged deficiency can cause lasting problems.

Clinical reference

Before explaining

Interpret B12 with symptoms and confirmatory tests when indicated; assess malabsorption and neurologic findings.

Warning signs

Progressive weakness, balance problems or confusion warrants prompt assessment and treatment.

Follow-up

Review blood and symptom response and whether long-term replacement is required.

Sources

Checked September 24, 2026.

Vitamin D deficiency

What to say

Vitamin D helps your body use calcium. Most healthy adults under 75 don’t need a blood test or extra vitamin D beyond the usual daily amount. We test when a condition makes a low level likely.

If your level is low, a daily vitamin D3 supplement usually works; some people need a short prescription course. More isn’t better: very high doses can push calcium too high. Call us for unusual thirst, frequent urination or constipation.

Clinical reference

Before explaining

Test only with an established indication (e.g., hypocalcemia, malabsorption, bariatric surgery, interacting drugs); no routine screening (Endocrine Society 2024).

Warning signs

Excess dosing (usually >10,000 IU/day) causes hypercalcemia: thirst, polyuria, constipation, kidney stones or injury.

Follow-up

Prefer daily over intermittent high-dose vitamin D at age ≥50; consider empiric daily supplementation at ≥75 without testing.

Sources

Checked October 15, 2026.

Hard questions

Are you sure it’s not cancer?

What to say

Use after assessing the symptom and cancer risk. Don’t imply that an assessment you haven’t done was reassuring.

Start with

I can hear that cancer is on your mind. I can explain what we know so far, but I can’t promise certainty that we don’t have.

Explain

The findings that matter here are [findings and what they mean]. My recommendation is [test, referral or observation] because [reason]. If we watch this for now, we’ll review it on [date], and [specific changes] should bring you back sooner.

Then ask

What made you think of cancer? Was it a change you’ve noticed, something in your family, or another experience?

Clinical reference

Before answering

Review the symptom course, examination, risk factors and relevant results. Use the appropriate diagnostic pathway; a normal screening test does not settle a new symptom.

Watch for

Persistent or changing symptoms may require investigation or referral. Give symptom-specific urgent precautions; avoid unsupported statements that risk is zero.

Follow-up

Name who will review results and when. Arrange reassessment even when initial testing is reassuring if symptoms remain unexplained.

Sources

Checked September 22, 2026.

Why won’t you order an MRI?

What to say

Use for assessed, uncomplicated low back pain when imaging would not change treatment. It is not a general reason to decline an MRI.

Start with

You want to understand what’s causing the pain. Let me explain why I’m recommending this plan and when a scan would help.

Explain

Based on today’s assessment, an MRI is unlikely to change how we treat your back pain right now. I recommend [treatment] and a review on [date]. If your symptoms or examination change, we’ll reconsider imaging. New trouble passing urine, loss of bladder or bowel control, numbness around the groin, or rapidly worsening leg weakness needs emergency assessment.

Then ask

What are you most hoping the scan will tell us?

Clinical reference

Before answering

Assess for cancer, infection, fracture and neurologic compromise before giving this answer. Do not use it to justify an insurance denial of clinically indicated imaging.

Watch for

Suspected serious pathology changes the pathway. New or progressive neurologic deficits require prompt reassessment.

Follow-up

Set a review interval based on symptoms and function. Reconsider imaging or referral when findings or the treatment decision warrant it.

Sources

Checked September 22, 2026.

Why won’t you give me antibiotics?

What to say

Use for a respiratory illness assessed as viral, with no current indication for an antibiotic.

Start with

You’re feeling miserable and want something that helps. Here’s what I think is causing this and what we can do for the symptoms.

Explain

Your symptoms and examination fit [viral illness]. Antibiotics treat certain bacterial infections. They don’t treat this virus. They can still cause side effects, including diarrhea or an allergic reaction. I recommend [symptom treatment]. We expect [course]. Contact us for [specific worsening] or if you’re not improving by [date].

Then ask

Is there a symptom we haven’t addressed, or something about this illness that feels different from what you’ve had before?

Clinical reference

Before answering

Confirm the working diagnosis and assess severity, host risk and indications for testing or antiviral treatment. Do not generalize this response to all coughs, sore throats or sinus symptoms.

Watch for

New breathing difficulty, severe illness or deterioration needs reassessment rather than repeating reassurance.

Follow-up

Offer an actual symptom plan, expected course and a clear route back to care.

Sources

Checked September 22, 2026.

What if I don’t take this medicine?

What to say

Discuss the specific medicine and condition; distinguish declining a new prescription from stopping existing treatment.

Start with

We can talk through that. I’d like you to understand what each option could mean, and I want to understand your concerns.

Explain

I recommend this medicine to [goal]. Without it, the main concern is [individualized consequence and timeframe]. The alternatives are [reasonable options], with [tradeoffs]. If you’re already taking it, let’s check whether stopping needs a taper or another treatment first.

Then ask

What gives you the most pause about taking it?

Clinical reference

Before answering

Explain benefits, harms and the option of no treatment where applicable. Assess understanding, practical barriers and urgency without labeling disagreement as incapacity.

Watch for

If refusal or interruption creates immediate risk, explain that risk plainly and arrange timely care. Respect an informed decision and continue offering support.

Follow-up

Document the patient’s preference, agreed alternative and review date. Make it easy to reopen the decision.

Sources

Checked September 22, 2026.

Am I going to need this forever?

What to say

Use with a named medicine, its indication and an individualized review plan.

Start with

The expected duration is [short course, trial or likely long-term treatment]. We should be clear about why you’re taking it and when we’ll review it.

Explain

For this medicine, we’ll look at [symptom, measurement or prevention goal], side effects and changes in your health. If the balance changes, we can discuss adjusting or stopping it. Feeling better can mean treatment is working. It doesn’t always mean the condition has gone away. Some medicines need a gradual reduction.

Then ask

What concerns you most about taking it long term?

Clinical reference

Before answering

Confirm the indication, expected duration and whether withdrawal, rebound or relapse is relevant. Do not promise eventual discontinuation for a treatment likely to remain necessary.

Watch for

New adverse effects or changing goals warrant an earlier review. Check the specific medicine’s stopping instructions.

Follow-up

Record a review date and the criteria for continuing, changing or stopping treatment.

Sources

Checked September 22, 2026.

I can’t afford this. What else can we do?

What to say

Use when the patient can’t afford a medicine, test or referral.

Start with

Thank you for telling me. Let’s work out a plan you can actually use.

Explain

We can check [a lower-cost medicine, covered service or assistance option] and what you would pay. I don’t want to promise a price before it’s confirmed. We also need to decide what to do while we sort that out, especially if you’re about to run out of treatment.

Then ask

Is the main problem the price itself, the insurance process, or costs like transportation or time away from work?

Clinical reference

Before answering

Identify the actual barrier and clinical urgency. Verify suitability of substitutions and out-of-pocket cost with the pharmacy or service; coverage alone does not establish affordability.

Watch for

An imminent treatment gap or delay in urgent evaluation needs a same-day plan.

Follow-up

Assign someone to confirm access by a specific date and contact the patient. Provide a fallback if assistance or coverage is declined.

Sources

Checked September 22, 2026.

Another doctor told me something different. Who’s right?

What to say

Use when recommendations differ and the reason for the difference has not yet been established.

Start with

Hearing two different recommendations is confusing. Let’s put them side by side and see where they differ.

Explain

We may have had different information, or there may be more than one reasonable option. My recommendation is [plan] because [reason]. I’d like to review the other clinician’s note and, if needed, speak with them. We should agree on what you’ll do while we clarify this.

Then ask

What did the other clinician recommend, and what did they say it was meant to accomplish?

Clinical reference

Before answering

Obtain the actual recommendation and relevant records. Check whether the clinical situation changed; avoid guessing another clinician’s reasoning.

Watch for

Conflicting doses, duplicate treatment or incompatible instructions need prompt reconciliation. Do not ask the patient to combine plans.

Follow-up

Name who will reconcile the recommendations and when. Offer a second opinion when useful, and give one clear interim plan.

Sources

Checked September 22, 2026.

Are you saying this is all in my head?

What to say

Use when a patient feels their symptoms have been discounted, including after unrevealing tests.

Start with

No. I believe you’re experiencing these symptoms, and I’m sorry my explanation made you feel dismissed.

Explain

These results haven’t explained [symptom]. That doesn’t make it imaginary. Let’s review what we’ve checked, what still needs attention and what might help you function better now. If we discuss stress, sleep or emotional health, I’ll explain why they may matter to your care.

Then ask

What part of what I said felt dismissive, and what is the symptom keeping you from doing?

Clinical reference

Before answering

Review the history and examination without assuming a psychological cause from normal tests. Discuss any functional or mental-health diagnosis using its own clinical criteria.

Watch for

New findings, worsening symptoms or loss of function warrant reassessment. Support for distress can accompany continued medical care.

Follow-up

Agree on a symptom/function goal and a review date. Explain the purpose and limits of further testing.

Sources

Checked September 22, 2026.

Why don’t we know what’s wrong yet?

What to say

Use when the diagnosis remains uncertain after assessment.

Start with

We don’t have a clear answer yet. I know that leaves you dealing with both the symptoms and the uncertainty.

Explain

So far, we know [findings]. We’ve made [possibility] less likely, but haven’t answered [remaining question]. The next useful step is [test, referral or observation] because [reason]. We can also work on [symptom relief] while we investigate.

Then ask

Has anything changed since we last talked, or is there a part of the story we haven’t spent enough time on?

Clinical reference

Before answering

Separate established findings from working explanations. State the limits of negative tests and the reason for each proposed next step.

Watch for

Worsening symptoms or new findings should reopen the assessment. Observation requires a clear return plan and access to review.

Follow-up

Set a date, a named clinician/team and specific reasons to seek earlier care. Track pending results and referrals.

Sources

Checked September 22, 2026.

Did something get missed?

What to say

Use as an opening response when a possible missed finding is raised and the facts are not yet established. If an error is known, acknowledge it directly.

Start with

That deserves a careful answer. Let’s look at what happened and what you need now.

Explain

What I can confirm is [known facts]. I still need to check [specific uncertainty]. I’ll review [records or results] with [responsible team] and update you by [date], even if the review is still underway. We’ll also address [current care need] now.

Then ask

Which symptom, result or part of the timeline makes you think something was missed?

Clinical reference

Before answering

Assess current harm first. Distinguish a suspected error from a confirmed one; state known errors plainly, apologize and explain corrective care. Do not speculate or minimize.

Watch for

Urgent clinical needs cannot wait for an investigation. Involve patient-safety/disclosure support when appropriate without delaying honest communication.

Follow-up

Identify a contact and update deadline. Share findings and corrective steps as they become known; do not promise an outcome before review.

Sources

Checked September 22, 2026.

The vaccine advice keeps changing. Who should I believe?

What to say

Use when a patient is unsure about a recommended vaccine because federal guidance has changed or is being disputed.

Start with

It’s been confusing, and it’s fair to have questions. Let’s focus on the specific vaccine we’re talking about.

Explain

The federal committee that advises on vaccines was replaced in 2025, and some of its decisions are now tied up in court. Major medical societies still publish their own schedules based on the research. My recommendation for [vaccine] comes from that evidence and your health: [reason]. Insurance coverage can differ, so we’ll check yours.

Then ask

What have you heard about this vaccine, and what worries you most?

Clinical reference

  • March 16, 2026: a federal court (D. Mass.) stayed the reconstituted ACIP’s appointments and votes and the January 2026 childhood schedule changes; an appeal is pending. Adult Tdap, HPV and hepatitis B recommendations are unchanged.

Before answering

Name the specific vaccine and indication. Check current CDC, AAFP or specialty-society guidance, the patient’s risk factors and prior doses, and coverage.

Watch for

Avoid politics and dismissiveness. Correct specific misinformation plainly; don’t let confusion delay vaccines whose recommendations are unchanged, such as Tdap.

Follow-up

Document the discussion and decision. Offer a written source, revisit at the next visit, and recheck coverage if federal or state guidance changes.

Sources

Checked October 15, 2026.

Should I get a full-body MRI or a blood test for cancer?

What to say

Use when a patient without symptoms asks about a self-pay full-body MRI or a multi-cancer blood test.

Start with

Wanting to catch cancer early makes sense. Let’s look at what these tests can and can’t do.

Explain

A full-body MRI often finds harmless spots that lead to more scans and procedures. Multi-cancer blood tests miss many cancers and can give false alarms. Neither has been shown to help people live longer, and both are usually paid out of pocket. Let’s make sure your proven screenings, like [colon, breast, cervical or lung], are up to date.

Then ask

What’s got you thinking about this now: a family history, a symptom, or worry about cancer in general?

Clinical reference

  • Galleri: an FDA advisory panel voted 7–2 that benefits outweigh risks (Sept 23, 2026); the FDA decision is pending. It is sold as a lab-developed test and is usually self-pay.

Before answering

Ask about symptoms, which need diagnostic evaluation, and family or genetic risk, which may justify targeted screening. Review overdue guideline screenings first.

Watch for

A positive blood test needs a planned diagnostic workup. A negative test or normal scan doesn’t rule out cancer or replace routine screening.

Follow-up

If the patient proceeds, agree beforehand who will review results and how findings will be followed up. Keep routine screening on schedule.

Sources

Checked October 15, 2026.

Can I just use compounded semaglutide?

What to say

Use when a patient asks about compounded or telehealth semaglutide or tirzepatide, often because of cost.

Start with

That’s a fair question, given what these medicines cost. Let’s find a safe option you can afford.

Explain

Compounded versions aren’t FDA approved, so the FDA doesn’t check their safety, quality or how well they work. The FDA has reports of hospital stays after people measured the wrong dose. The shortage is over, and some approved medicines, including pills, now have lower cash prices; let’s check yours. If you still choose compounded, use a state-licensed pharmacy and confirm your dose in milligrams.

Then ask

Is cost the main barrier, or is it insurance rules or getting a prescription?

Clinical reference

  • Semaglutide and tirzepatide are no longer in shortage. FDA proposed (Apr 30, 2026) removing semaglutide, tirzepatide and liraglutide from the 503B bulks list; final action is pending.

Before answering

Screen as for the approved drug. Ask the source pharmacy, base versus salt form, concentration, dose in mg and syringe volume.

Watch for

Dose errors (units vs mg vs mL), severe vomiting or dehydration, pancreatitis symptoms, fraudulent labels, and vials used beyond 28 days after first use.

Follow-up

Price-check approved options and coverage. If compounded use continues, review injection technique, document the product, and report adverse events to MedWatch.

Sources

Checked October 15, 2026.

Can you just refill my Xanax, Adderall or pain medicine?

What to say

Use when a new or transferring patient asks for a benzodiazepine, stimulant or opioid refill.

Start with

I hear that you need this, and I don’t want you to run out. Stopping some of these medicines suddenly can cause dangerous withdrawal.

Explain

First, California law requires me to check the state prescription database, and I’ll need records from your last prescriber. If I prescribe, we’ll use a treatment agreement: regular visits, one prescriber, one pharmacy, no early refills and sometimes urine tests. Then we’ll decide together whether to continue, taper slowly, switch or refer you.

Then ask

What does this medicine help you do, and what are your goals for it?

Clinical reference

  • California H&S Code §11165.4: review CURES (past 12 months) before first prescribing a Schedule II–IV drug and at least every 6 months while renewing it; some exemptions apply.

Before answering

Check CURES, obtain prior records and dose history, and screen for substance use disorder and risky combinations such as opioids with benzodiazepines or alcohol.

Watch for

Withdrawal after abrupt stops (benzodiazepine seizures), overdose risk, early refill requests, multiple prescribers or unexpected test results.

Follow-up

Bridge briefly while records arrive, taper gradually if stopping, offer naloxone with opioids, and refer for use disorder treatment when indicated.

Sources

Checked October 15, 2026.

Why did I get a bill for my physical?

What to say

Use when a patient is surprised by a charge after a preventive visit, or asks how to avoid one.

Start with

A surprise bill is frustrating. Let’s figure out what it was for.

Explain

Preventive visits and recommended screenings are usually free when you see an in-network clinician. But if we also handled a new or ongoing problem, like a new symptom or a medicine change, that’s billed separately and can have a copay or deductible. Some lab tests don’t count as preventive, either. We’ll tell you when we’re going beyond the checkup, so you can choose to save it for another visit.

Then ask

What does the bill show, and what were you expecting it to cover?

Clinical reference

Before answering

Review what was billed (preventive code, separate problem visit, non-preventive labs) and network status. Medicare covers an Annual Wellness Visit, not a routine physical.

Watch for

Don’t defer urgent or worsening problems to avoid a charge; address safety issues at the visit even if they’re billed separately.

Follow-up

Send coding questions to billing. Uninsured or self-pay patients can get a good faith estimate and may dispute bills at least $400 above it.

Sources

Checked October 15, 2026.

Can we cover all my concerns today?

What to say

Use at the start of a visit when a patient brings several concerns or a list.

Start with

I’m glad you brought a list. I want to get to what matters most, so let’s hear everything before we start.

Explain

We may not have time to do every concern justice today. Let’s pick the most important or urgent ones for this visit and make a clear plan for the rest: a follow-up visit, a portal message, or time with [team member]. If anything sounds urgent, like chest pain or new weakness, we’ll deal with that first.

Then ask

Of everything on your list, which matters most to you today?

Clinical reference

  • In recorded visits, clinicians elicited the patient’s agenda in 36% and then interrupted after a median of 11 seconds; uninterrupted patients finished in a median of 6 seconds.

Before answering

Elicit the full agenda before exploring any one concern; ask “What else?” until the list is complete. Scan it for red flags and time-sensitive items.

Watch for

Never defer red flags (chest pain, suicidal thoughts, new neurologic symptoms) for time. A concern raised at the door may be the main one.

Follow-up

Document deferred concerns and the plan for each, book follow-up, and use team members or portal messages for items that don’t need a visit.

Sources

Checked October 15, 2026.

I saw my results before you called. Should I be worried?

What to say

Use when a patient sees results in the portal before the care team has reviewed or explained them.

Start with

I’m sorry you saw those results without an explanation. That can be really unsettling.

Explain

Under federal rules, most results now go to your portal as soon as they’re ready, often before I’ve seen them. A value marked high or low isn’t always a problem; it depends on your health and past results. I’ll review these and contact you by [date]. If a result needs urgent action, we call right away. If you’d rather hear from us first, we can talk about how results are released.

Then ask

What did you see that worried you most?

Clinical reference

  • ONC: an organizational delay so clinicians can review results first is likely information blocking; honoring an individual patient’s request to delay likely is not.
  • California H&S Code §123148(f): a positive HIV test, hepatitis antigen, drug-abuse results, and tissue or imaging results showing new or recurrent malignancy aren’t posted electronically unless the patient requests it, the clinician deems it appropriate, and a clinician has first discussed them with the patient.

Before answering

Review the result in context (trend, reference range, symptoms). Know your EHR’s release rules; California restricts portal posting of some sensitive results.

Watch for

Critical values need same-day contact. A patient who saw a possible cancer, HIV or other serious result without discussion needs a prompt, direct conversation.

Follow-up

Reply by the promised date, even if results are normal. Offer to record a preference to delay portal release where your system allows it.

Sources

Checked October 15, 2026.

What happens if I can’t speak for myself?

What to say

Use for any adult, especially before surgery, after a serious diagnosis, or with frailty.

Start with

That’s an important question, and it’s best answered now, while you can decide.

Explain

First, choose a health care agent: someone you trust to make decisions if you can’t. Tell them what matters most to you, and put it in writing in an Advance Health Care Directive. We can give you a form. If you’re seriously ill or frail, we can also fill out a POLST, a medical order emergency teams follow. Share copies with your agent, family and us; update them after big changes.

Then ask

If you became very sick, what would matter most to you?

Clinical reference

Before answering

Ask whether a directive or POLST exists and whom the patient wants as agent. Scan existing documents into the chart.

Watch for

POLST is for serious illness or frailty, not healthy adults. California POLST is signed by the patient or decision-maker and a physician, NP or PA.

Follow-up

Revisit at least yearly and after hospitalization, a new diagnosis or major life changes. Confirm the agent has a current copy.

Sources

Checked October 15, 2026.

I looked this up, and an AI told me…

What to say

Use when a patient brings information from a search engine, AI chatbot or social media.

Start with

Thanks for bringing that in. I’m glad you’re looking into this, and I’d like to go through it together.

Explain

AI tools and websites can be helpful, but they can also be wrong, out of date, or miss details about your health and history. I’ll tell you which parts fit your situation, which don’t, and why. Be careful about uploading records or personal details to apps or chatbots; health privacy laws may not protect what you share there.

Then ask

What were you hoping to learn, or what did it say that worried you?

Clinical reference

Before answering

Ask what tool or source and what question they used. Address the specific claim; note where it conflicts with the patient’s history, medicines or results.

Watch for

AI advice that delays urgent care, changes medicines or doses, or recommends unproven treatments needs a direct, specific correction.

Follow-up

Point to reliable sources such as MedlinePlus, document the agreed plan, and invite future questions through visits or the portal.

Sources

Checked October 15, 2026.

Can I still drive?

What to say

Use when a medical condition, medicine or change in function raises concern about driving safety.

Start with

Driving means independence. I’ll be honest about my concern, and we’ll plan this together.

Explain

I’m concerned that [seizure, fainting, memory changes, vision or a medicine] could cause a crash. For now, I recommend [stopping, limiting or continuing driving until date]. California law requires doctors to report some conditions that affect driving, such as seizures or dementia. The DMV then reviews your license and keeps that information confidential. A formal driving evaluation can help us decide.

Then ask

What does driving let you do, and how else could you get around for now?

Clinical reference

Before answering

Name the specific risk (seizure, syncope, cognition, vision, sedation). California (H&S §103900; 17 CCR §2806–2812) requires reporting qualifying lapse-of-consciousness disorders, including dementia, to the local health officer within 7 days.

Watch for

Recent seizure, unexplained syncope, crashes, near-misses, getting lost or family concern call for clear advice not to drive until reassessed. Commercial drivers have separate federal rules.

Follow-up

Document the advice and any report. Reassess as the condition changes; consider an occupational therapy driving evaluation and help plan other transportation.

Sources

Checked October 15, 2026.

Why do you keep bringing up my weight?

What to say

Use when a patient feels judged or frustrated that weight keeps coming up, especially when they came for something else.

Start with

I’m sorry if it felt like I was judging you or not listening. You deserve care for what brought you in.

Explain

Let’s start with [your main concern]. I’ll bring up weight only when it affects a specific problem, like [knee pain, sleep apnea or blood pressure], and I’ll ask first. Even then, we can focus on habits and health, not a number. If we don’t need your weight today, you can skip the scale or choose not to see it.

Then ask

What matters most to you about your health right now?

Clinical reference

Before answering

Address the presenting concern first. Ask permission before discussing weight and use neutral, person-first language. Know when weight is clinically needed (dosing, heart failure, CKD, eating disorders).

Watch for

Weight stigma leads people to delay or avoid care. Screen for disordered eating; don’t attribute new symptoms to weight without evaluating them.

Follow-up

Record the patient’s preferences about weighing and discussing weight. Revisit only with permission or when weight changes management.

Sources

Checked October 15, 2026.

Should I take vitamins or supplements?

What to say

Use when a patient asks about vitamins or supplements for general health or disease prevention.

Start with

Many people wonder about this. Let’s see what you actually need.

Explain

If you eat a varied diet, a daily multivitamin hasn’t been shown to prevent heart disease or cancer. Some people need a specific supplement, such as folic acid when pregnancy is possible, or B12 if you eat no animal foods. The FDA doesn’t approve supplements for safety or benefit before they’re sold. Some interact with medicines; St. John’s wort can make birth control less reliable. Bring in everything you take.

Then ask

What are you hoping a supplement will do for you?

Clinical reference

Before answering

Review every product and dose. USPSTF: insufficient evidence for multivitamins; recommends against beta-carotene or vitamin E to prevent CVD or cancer. Folic acid 0.4–0.8 mg daily if pregnancy is possible.

Watch for

St. John’s wort induces CYP3A4 (OCs, DOACs, HIV and transplant drugs). Ginkgo or high-dose fish oil with anticoagulants. Biotin skews immunoassays. Weight-loss, sexual and bodybuilding products may hide drugs.

Follow-up

Keep a reconciled supplement list. Test levels only when results would change management; stop products without a clear purpose.

Sources

Checked October 15, 2026.

Can you check my hormones or give me testosterone for energy?

What to say

Use when a man asks for hormone testing or testosterone for low energy, low sex drive or “low T” symptoms.

Start with

Feeling worn out is hard, and I want to find the cause.

Explain

Low energy has many causes, like poor sleep, stress, low mood, alcohol or medicines. If your symptoms fit, we’ll check testosterone with morning blood tests on 2 days. Treatment is for levels that are truly low. It can lower sperm count, raise blood pressure and red blood cell counts, and increase clot risk. Be cautious with clinics that skip these steps.

Then ask

What have you noticed, and what would you most like to change?

Clinical reference

Before answering

Screen first for sleep problems, depression, alcohol, opioids and weight change. If symptoms fit, measure fasting morning total T twice, then LH/FSH if low. Ask about fertility plans and wellness-clinic products.

Watch for

Before treating: hematocrit, BP, PSA discussion, untreated severe OSA and VTE history. Testosterone suppresses spermatogenesis. Ask about anabolic steroids, SARMs or peptides.

Follow-up

Explain results and other causes found. If treating confirmed deficiency, recheck symptoms, T, hematocrit and BP at 3–6 months, then yearly; reconsider if no benefit.

Sources

Checked October 15, 2026.

Why are you asking about my sex life?

What to say

Use when a patient is surprised or uncomfortable that sexual health questions are part of the visit.

Start with

That’s a fair question. I ask everyone these questions, whatever their age, gender or relationship status.

Explain

Your answers help me suggest the right tests, vaccines, birth control or HIV prevention, like PrEP. I’m not here to judge anyone’s partners or practices, and you can skip any question. What you tell me stays private in your medical record, unless someone is being hurt or is in danger. Your insurer may see codes for tests we bill.

Then ask

Is there anything about your sexual health you’d like to talk about today?

Clinical reference

Before answering

Use the 5 Ps: partners, practices, protection from STIs, past STIs and pregnancy intention. Don’t assume orientation or gender identity; use the patient’s terms.

Watch for

Coercion, violence or trading sex needs a safety assessment and support. Know your reporting duties before promising confidentiality.

Follow-up

Offer STI testing, HPV and hepatitis vaccines, PrEP, doxy-PEP or contraception as indicated. Document sensitively and note confidential-contact preferences.

Sources

Checked October 15, 2026.

Will my employer or family see this?

What to say

Use when a patient worries that an employer, family member or the insurance policyholder could learn about their care.

Start with

That’s an important question, and it makes sense to ask before you share something personal.

Explain

We won’t share your health information with your employer without your written permission, unless a law requires it, as with some workers’ compensation claims. Family can’t see your records or portal unless you give them access. Your insurance gets billing details. You can ask your health plan to send notices about sensitive care, like sexual or mental health care, only to you. A few safety situations require reports by law.

Then ask

What are you most worried someone might see?

Clinical reference

Before answering

HIPAA: no disclosure to employers without authorization unless law requires it (e.g., workers’ compensation). Family involved in care: share unless the patient objects; emergencies allow best-interest sharing.

Watch for

California Civil Code §56.107 requires state-regulated plans to send sensitive-service communications, including EOBs, directly to the patient; self-funded employer plans may differ. Check portal proxy access.

Follow-up

Record contact and proxy preferences and confidential-communication requests. Tell the patient before any legally required report when safe.

Sources

Checked October 15, 2026.

What would you do if you were me?

What to say

Use when a patient asks for your personal recommendation between reasonable options.

Start with

I’m glad you asked. I’ll give you a clear recommendation based on what you’ve told me matters to you.

Explain

Since [their priority] matters to you, I’d choose [option] because [reason]. My own choice might differ, because my life and priorities aren’t yours. I’d think differently if [what would change the advice]. [Other options] are also reasonable. Whatever you decide, I’ll support you, and we can revisit it.

Then ask

How does that fit with what matters most to you?

Clinical reference

Before answering

Confirm the options, benefits and harms have been explained. Base the recommendation on the patient’s goals and circumstances, not your own preferences.

Watch for

A strong recommendation can silence disagreement. Watch for deference, family pressure or a choice that conflicts with stated goals.

Follow-up

Document the recommendation, the patient’s choice and reasoning. Offer decision aids, time or a second opinion, and set a time to revisit.

Sources

Checked October 15, 2026.

How long do I have?

What to say

Use when a patient with a serious or life-limiting illness asks about prognosis. Review the illness course and specialist input first.

Start with

That’s a hard question. I’ll be honest, and you can tell me how much detail you want.

Explain

No one can know exactly. Based on [illness and recent changes], my best estimate is [hours to days, days to weeks, weeks to months, or months to years]. Some people live longer and some shorter. We can hope for the best and also prepare. Palliative care can ease symptoms now, alongside treatment. Hospice focuses on comfort in the last months of life.

Then ask

As we plan, what matters most to you, and who would you like involved?

Clinical reference

Before answering

Ask what and how much the patient wants to know first. Review the disease course, functional decline and specialist input; give a range, not a single number.

Watch for

Uncontrolled symptoms, severe distress or questions about hastening death need prompt attention. Some patients prefer that family hear details; confirm this.

Follow-up

Offer palliative care; discuss hospice when prognosis is likely 6 months or less. Complete an advance directive or POLST, and schedule the next conversation.

Sources

Checked October 15, 2026.

Can you fill out my disability or work forms?

What to say

Use when a patient asks for medical certification for leave, disability benefits or workplace accommodations.

Start with

Yes, when your medical situation supports it. I want the form to be accurate so it helps you.

Explain

I can describe your diagnosis, how it limits what you can do, and how long that’s likely to last. Your employer or the agency, such as the EDD for state disability, decides whether you qualify. I may need a visit or records first. Forms usually take [number] business days, and [fee policy]. Please send them early and tell us the deadline.

Then ask

What are the forms for, and when are they due?

Clinical reference

Before answering

Certify only what the record supports: diagnosis, functional limits, restrictions and expected duration or episodes. Ask for job duties. Common forms: FMLA (WH-380-E/F), CFRA, EDD SDI/PFL, ADA accommodation.

Watch for

Don’t overstate limits or extend leave without findings. EDD needs a specific recovery date, not “unknown” or “indefinite,” and may send long claims for an independent exam.

Follow-up

Track deadlines and set a recertification or return-to-work date. Reassess function at follow-up and update restrictions or accommodations.

Sources

Checked October 15, 2026.

Can I record this visit?

What to say

Use when a patient asks to record the visit, or you learn they have been recording.

Start with

It makes sense to want to remember what we talk about. Thank you for asking first.

Explain

In California, recording a private conversation takes everyone’s consent. [Our policy on audio recording.] If we agree, please tell me when it’s on, and we can pause for the exam or for anyone else’s information. I’ll also give you a written plan.

Then ask

What would you most like to go back to: the instructions, the medicine plan, or something to share with family?

Clinical reference

Before answering

Penal Code 632 requires every party’s consent to record a confidential communication. Apply clinic policy, include others in the room, and ask why the patient wants to record.

Watch for

Secret recording, or recording other patients or staff, calls for a calm, clear boundary. Distrust behind the request may signal an unaddressed concern.

Follow-up

Document consent or refusal. Offer a written plan, an after-visit summary, or a family member joining by phone as alternatives.

Sources

Checked October 15, 2026.

Can you write an emotional support animal letter?

What to say

Use when a patient asks for a letter supporting an emotional support animal.

Start with

Your animal matters to you, and I want to understand how it helps.

Explain

An emotional support animal isn’t a service animal, which is a dog trained for specific tasks, so it has no public-access or airline rights. For housing, California law can still require a landlord to make an exception when there’s a disability-related need. I can write a letter when I know you and have evaluated that need. For a support dog, California requires that I’ve known you at least 30 days first.

Then ask

How does your animal help you day to day?

Clinical reference

Before answering

Complete and document a clinical evaluation. For support-dog letters, California requires a 30-day relationship (waived if verified homeless), license details and the Penal Code 365.7 notice.

Watch for

Distress, safety or housing-loss concerns behind the request need assessment and care, not just paperwork. Letters cannot promise housing or travel access.

Follow-up

Offer an evaluation visit if criteria are not yet met. Treat the underlying condition, and review the letter if the situation changes.

Sources

Checked October 15, 2026.

Why are you asking about guns at home?

What to say

Use when a patient asks why you screen for firearms at home.

Start with

It’s fair to wonder why I’m asking.

Explain

I ask everyone, the way I ask about seat belts and smoke alarms. This is about safety, not politics or taking anything from you. Firearms stored locked and unloaded, with ammunition kept separately, lower the risk of accidents and suicide, especially when children, teenagers, memory problems or a hard time are part of the picture.

Then ask

Is there anything about the question that worries you?

Clinical reference

Before answering

Ask everyone, without judgment. Ask about children, teens, dementia, suicidal thoughts, domestic violence or substance use at home; storage matters most when risk is higher.

Watch for

Suicidal intent, threats to others or unsafe access with dementia need a same-day safety plan (911, 988). Clinicians aren’t listed as petitioners for a California gun violence restraining order; police can seek one.

Follow-up

Offer storage resources or temporary off-site storage; check current California transfer rules first. Document the discussion and revisit when mood, health or home circumstances change.

Sources

Checked October 15, 2026.

Why do I need a visit for a refill?

What to say

Use when a patient questions a visit requirement for a routine refill.

Start with

I know it’s frustrating to book a visit when you just want your medicine.

Explain

Some medicines need regular checks, like blood pressure, blood tests or side effects, and we should confirm you still need it. That’s how I can refill it safely. I’ll send [a bridge supply] so you don’t run out before [date]. Once you’re stable, we can look at a video visit, a longer supply or matching refill dates.

Then ask

What makes visits hard for you: time off work, cost, or getting here?

Clinical reference

Before answering

Identify what monitoring is due (labs, blood pressure, adverse effects, ongoing need) and whether a bridge supply is safe. Controlled substances follow separate rules.

Watch for

An imminent gap in insulin, an anticoagulant, or seizure, heart or psychiatric medicine needs a same-day plan. Don’t let access barriers quietly end treatment.

Follow-up

Set the visit date, the bridge quantity and when monitoring is due. Once stable, ask about telehealth, longer supplies and synchronized refills.

Sources

Checked October 15, 2026.

My watch says I have atrial fibrillation.

What to say

Use when a patient reports a smartwatch or wearable alert for atrial fibrillation or an irregular rhythm.

Start with

Thank you for telling me. I take this seriously, and we can check it properly.

Explain

A watch can flag an irregular pulse, but it can’t diagnose atrial fibrillation, and alerts can be wrong. We confirm it with an ECG or a heart monitor you wear. It matters because atrial fibrillation can raise stroke risk, which treatment can lower. Please bring or send the watch tracing. Call 911 for chest pain, fainting, severe breathlessness, or stroke signs: face drooping, arm weakness or trouble speaking.

Then ask

Did you notice racing, fluttering or dizziness when the alert came?

Clinical reference

Before answering

Review the tracing, symptoms and stroke risk. Confirm AF with a 12-lead ECG or ambulatory monitor; wearable photoplethysmography alone is not sufficient for diagnosis.

Watch for

Chest pain, syncope, severe dyspnea or stroke signs need 911. Hemodynamic symptoms or a rapid rate need same-day assessment.

Follow-up

Arrange an ECG or extended monitor. If AF is confirmed, calculate stroke risk and discuss anticoagulation; if not, review any further alerts.

Sources

Checked October 15, 2026.

You look too young to be my doctor.

What to say

State your actual role and training; disclose supervision when applicable.

Start with

You want to know who is taking care of you. I’m [name], the [role] seeing you today.

Explain

My training is [brief, accurate description], and my experience with this problem is [relevant experience]. [If applicable: I’m working with Dr. [name], who supervises your care.] I’ll explain my recommendations and involve another clinician when needed.

Then ask

Is your concern about my experience with this particular problem, or something in the plan we’ve discussed?

Clinical reference

Before answering

Clarify credentials without exaggerating independence or experience. A comment about appearance may reflect uncertainty about team roles.

Watch for

Address a specific care concern on its merits. If the patient asks to change clinicians, discuss feasible options.

Follow-up

Clarify who is responsible for care and any promised supervisory review.

Sources

Checked September 23, 2026.

How much experience do you have with this?

What to say

Use for questions about a condition, procedure or level of training.

Start with

That’s a reasonable thing to ask. My experience with [condition or procedure] is [honest description].

Explain

For your situation, I can [work within your competence]. For [part requiring additional expertise], I would involve [colleague or specialist]. [If supervised: Dr. [name] will be involved by [specific supervision arrangement].] I can also explain the alternatives before you decide.

Then ask

What would you like to know about my training, the procedure or who else would be involved?

Clinical reference

Before answering

Use accurate experience figures if known; do not invent case counts or outcomes. Explain trainee status and supervision before consent.

Watch for

A genuine skill or scope limitation requires support or referral. Reassurance cannot substitute for competence.

Follow-up

Arrange any agreed consultation or second opinion and confirm the plan before proceeding.

Sources

Checked September 23, 2026.

Are you a man or a woman?

What to say

A brief personal answer is optional. This wording redirects to the care concern.

Start with

You can call me [name]. I’m the [role] looking after you today.

Explain

I can explain my training and what today’s visit involves. If you have a concern about an examination or about feeling comfortable, we can discuss that before proceeding.

Then ask

Is there something about today’s care that you’d like us to address?

Clinical reference

Before answering

Do not assume hostility from the question alone. The clinician can choose a brief answer or a privacy boundary; personal history is not evidence of competence.

Watch for

Persistent intrusive questions or insults may need a boundary. Address a request for an intimate-exam accommodation separately.

Follow-up

Agree on any exam accommodations and obtain consent before proceeding.

Sources

Checked September 23, 2026.

Are you gay?

What to say

For a clinician who prefers to keep their personal life private.

Start with

I keep my personal life private, but I’m happy to talk about your care.

Explain

If you’re wondering whether I understand your health concerns or will treat you respectfully, we can talk about that. My relevant experience is [accurate description]. You can tell me what you need without sharing anything you aren’t ready to discuss.

Then ask

Is there a concern about your care behind the question?

Clinical reference

Before answering

The question may seek connection or affirming care. Do not assume harassment. Clinicians may choose limited disclosure, but this wording does not require it.

Watch for

Repeated sexual questions, comments or advances after a boundary call for a clearer limit and team support.

Follow-up

Address the patient’s underlying concern, including a request for relevant expertise or another clinician.

Sources

Checked September 23, 2026.

I’d prefer a clinician of another gender for this exam.

What to say

Use before a sensitive examination; a request does not require disclosure of trauma.

Start with

Thank you for telling me before we start. Let’s look at what would help you feel comfortable.

Explain

We can check whether a clinician who meets your preference is available and discuss any wait. A trained chaperone may also help if you’d like one. I’ll explain why the exam matters and whether waiting could affect your health. You can decline or ask us to stop the examination.

Then ask

Would you like us to check for another clinician, arrange a chaperone, or talk through the exam first?

Clinical reference

Before answering

Clarify the requested accommodation without demanding a personal explanation. Check urgency, availability, consent and chaperone policy.

Watch for

A chaperone does not replace consent or necessarily meet the request. Explain urgent risks without pressuring the patient to accept an exam.

Follow-up

Confirm the chosen arrangement, any delay and a safe interim plan.

Sources

Checked September 23, 2026.

I want a different clinician.

What to say

Use for a request to change the clinician for this visit or ongoing care.

Start with

I hear that you’d prefer someone else. We can discuss the options.

Explain

I’ll check who is available and what a change would involve. If something in this visit has concerned you, I’m willing to listen, but you don’t have to explain it to me to ask about a change. We also need a plan for [time-sensitive care] while arrangements are made.

Then ask

Are you asking for someone else today, a second opinion, or a change in your ongoing clinician?

Clinical reference

Before answering

Assess urgency and clarify the request. Offer a practice manager or patient-relations contact; availability may limit immediate reassignment.

Watch for

Do not promise an unavailable clinician, obstruct a second opinion or leave urgent needs unattended. Discriminatory conduct needs a separate response.

Follow-up

Name who will coordinate the request and when. Confirm responsibility for refills, pending results and follow-up during any transition.

Sources

Checked September 23, 2026.

I don’t want someone like you treating me.

What to say

Use when identity-based derogatory conduct is clear; distinguish it from a respectful care preference.

Start with

I’m willing to discuss concerns about your care. Comments putting people down because of who they’re need to stop.

Explain

We can talk about your treatment and the available options for another clinician. I can involve [team lead or practice manager] to help. We also need to address [urgent care need] safely while we decide what happens next.

Then ask

Can we continue this discussion respectfully with [team member] present?

Clinical reference

Before answering

Consider confusion, illness, communication barriers and past experiences. Support the targeted clinician rather than requiring them to manage the encounter alone.

Watch for

Threats require de-escalation and safety support. Do not force nonconsensual care or abruptly abandon urgent needs.

Follow-up

Record specific words and actions objectively. Use organizational processes for reassignment or any later termination of the care relationship; offer staff support.

Sources

Checked September 23, 2026.

Finish the conversation

Agree on the next step

Let’s review this on [date]. We’ll judge progress by [symptom, reading, or activity]. Contact [team and phone number] sooner if [specific change]. If cost or difficulty following the plan gets in the way, tell us so we can adjust it.

Explain how results will arrive

You should hear from [clinician or team] by [date] through [phone or portal]. If you haven’t heard by then, contact [team and phone number]. Don’t assume silence means the result was normal. For a same-day concern, call rather than waiting for a portal reply.

Check that the plan is clear

I want to make sure I explained this clearly. In your own words, how will you follow this plan, what would make you call us sooner, and when are we checking in again?